_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e53
_enti_e59
_enti_e56
_enti_e50
_enti_e52
_enti_e51
_enti_e54
_enti_e61
_enti_e57
_enti_e58
_enti_e60
_enti_e62
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
p1_propro_p1
PMID: 15809659,12591926
TRAF2 and TRAF5 also contain a RING domain and UbLys63 modifications can be detected in TRAF2 on TNF-alpha stimulation
c1 cso30:c:InputAssociation connector
c2 cso30:c:InputProcess connector
c7 cso30:c:InputAssociation connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 15809659,15258597
In addition, TRAF2 catalyses Lys 63 polyubiquitination of receptor-interacting protein (RIP)
c4 cso30:c:InputAssociation connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 15809659,12591926,11460167
Both TRAF2 and TRAF6 activate c-Jun amino-terminal kinase (JNK) in parallel to IKK, in a process that also depends on the assembly of UbLys63 chains
c8 cso30:c:InputAssociation connector
c9 cso30:c:InputProcess connector
c10 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 15809659
Figure 2A
PMID: 15809659
Ubiquitin (Ub) ligases (shown in green) catalyse the assembly of UbLys63 chains (green) on TRAF2, TRAF6, RIP and IKK-gamma, which is thought to recruit the protein kinase TAK1 through association with TAB2 or TAB3.
c11 cso30:c:InputProcess connector
c12 cso30:c:InputProcess connector
c13 cso30:c:OutputProcess connector
p4_propro_p5
PMID: 15809659
Figure 2A
PMID: 15809659
Ubiquitin (Ub) ligases (shown in green) catalyse the assembly of UbLys63 chains (green) on TRAF2, TRAF6, RIP and IKK-gamma, which is thought to recruit the protein kinase TAK1 through association with TAB2 or TAB3.
c14 cso30:c:InputProcess connector
c15 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 15809659,10215628
Genetic ablation has demonstrated an essential function of TRAF6 in IKK activation through IL-1 receptor (IL-1R) and Toll-like receptor (TLR) signalling
PMID: 15809659,11460167
TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization
PMID: 15809659
Figure 2A
c23 cso30:c:InputAssociation connector
c24 cso30:c:InputAssociation connector
c25 cso30:c:InputProcess connector
c26 cso30:c:OutputProcess connector
p8_propro_p9
PMID: 15809659,10215628
Genetic ablation has demonstrated an essential function of TRAF6 in IKK activation through IL-1 receptor (IL-1R) and Toll-like receptor (TLR) signalling
PMID: 15809659,11460167
TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization
PMID: 15809659
Figure 2A
c27 cso30:c:InputAssociation connector
c28 cso30:c:InputProcess connector
c30 cso30:c:InputAssociation connector
c29 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 15809659,11460167
TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization
PMID: 15809659,15492226
TRAF-interacting protein with forkhead-associated domain (TIFA) oligomers promote TRAF6 oligomerization and Ub ligase activity
c31 cso30:c:InputProcess connector
c32 cso30:c:InputAssociation connector
c33 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 15809659,11460167
TRAF6 undergoes trans-auto-ubiquitination , which is strongly enhanced by its forced oligomerization
PMID: 15809659,15492226
TRAF-interacting protein with forkhead-associated domain (TIFA) oligomers promote TRAF6 oligomerization and Ub ligase activity
c34 cso30:c:InputProcess connector
c35 cso30:c:InputAssociation connector
c36 cso30:c:OutputProcess connector
p3_propro_p12
PMID: 15809659,12591926,11460167
Both TRAF2 and TRAF6 activate c-Jun amino-terminal kinase (JNK) in parallel to IKK, in a process that also depends on the assembly of UbLys63 chains
c37 cso30:c:InputAssociation connector
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p4_propro_p13
PMID: 15809659
Figure 2A
PMID: 15809659
Ubiquitin (Ub) ligases (shown in green) catalyse the assembly of UbLys63 chains (green) on TRAF2, TRAF6, RIP and IKK-gamma, which is thought to recruit the protein kinase TAK1 through association with TAB2 or TAB3.
c40 cso30:c:InputProcess connector
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 15809659
TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification.
PMID: 15809659
Figure 2A
c43 cso30:c:InputProcess connector
c44 cso30:c:InputAssociation connector
c45 cso30:c:OutputProcess connector
p15_propro_p7
PMID: 15809659
TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification.
PMID: 15809659
Figure 2A
c20 cso30:c:InputAssociation connector
c21 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p15_propro_p6
PMID: 15809659
TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification.
PMID: 15809659
Figure 2A
c17 cso30:c:InputAssociation connector
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 15809659
Figure 2A
c46 cso30:c:InputAssociation connector
c47 cso30:c:InputProcess connector
c48 cso30:c:OutputProcess connector
p14_propro_p16
PMID: 15809659
Figure 2A
c49 cso30:c:InputAssociation connector
c50 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 15809659
TAK1 activates the IKK complex, which subsequently targets IkappaBs for BetaTrCP-mediated UbLys48 modification.
c52 cso30:c:InputAssociation connector
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 15809659
Figure2A
c58 cso30:c:InputAssociation connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p19_propro_p20
PMID: 15809659
Figure2A
PMID: 15809659,15122200
T-cell receptor (TCR) ligation triggers protein kinase Cdelta (PKCdelta)-mediated formation of a complex that consists of the CARMA1 (caspase recruitment domain-containing membrane-associated guanylate kinase protein 1), B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue (MALT1) proteins and transmits the signal to the IKK complex
c61 cso30:c:InputAssociation connector
c62 cso30:c:InputProcess connector
c63 cso30:c:OutputProcess connector
p21_propro_p21
MID: 15809659,15122200
T-cell receptor (TCR) ligation triggers protein kinase Cdelta (PKCdelta)-mediated formation of a complex that consists of the CARMA1 (caspase recruitment domain-containing membrane-associated guanylate kinase protein 1), B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue (MALT1) proteins and transmits the signal to the IKK complex
c64 cso30:c:InputAssociation connector
c66 cso30:c:InputProcess connector
c65 cso30:c:InputProcess connector
c67 cso30:c:InputProcess connector
c68 cso30:c:OutputProcess connector
p11_propro_p22
PMID: 15809659,15125833
BCL10 and MALT1 can induce E3 activity of TRAF6, and RNA interference (RNAi) suggests that TRAF2 and TRAF6 are necessary for IKK activation in Jurkat T cells after TCR ligation
c69 cso30:c:InputAssociation connector
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 15809659,11262391
BCL10 induces oligomerization of MALT1 which might enhance its Ub ligase activity.
c72 cso30:c:InputAssociation connector
c73 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 15809659,14695475
MALT1 triggers UbLys63 modification of Lys 399 in the carboxy-terminal zinc-finger domain of IKKgamma; mutation of this residue abolishes IKK/NF-KappaB activation by BCL10
c74 cso30:c:InputAssociation connector
c75 cso30:c:InputProcess connector
c76 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 15809659,15620648
Nucleotide-binding oligomerization domain 2 (NOD2), which functions as an intracellular sensor for bacteria, promotes RIP2-dependent NF-κB activation by inducing the assembly of Lys 63 polyUb chains at position Lys 285 of IKKgamma
c77 cso30:c:InputProcess connector
c78 cso30:c:InputProcess connector
c79 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 15809659,15620648
Nucleotide-binding oligomerization domain 2 (NOD2), which functions as an intracellular sensor for bacteria, promotes RIP2-dependent NF-κB activation by inducing the assembly of Lys 63 polyUb chains at position Lys 285 of IKKgamma
c80 cso30:c:InputAssociation connector
c81 cso30:c:InputAssociation connector
c82 cso30:c:InputProcess connector
c83 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 15809659,15620648
Nucleotide-binding oligomerization domain 2 (NOD2), which functions as an intracellular sensor for bacteria, promotes RIP2-dependent NF-κB activation by inducing the assembly of Lys 63 polyUb chains at position Lys 285 of IKKgamma
c85 cso30:c:InputProcess connector
c84 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 15809659,15226292
Expression of CYLD is induced by NF-KappaB, which provides a novel autoregulatory feedback pathway that could limit the duration of IKK activity
c87 cso30:c:InputAssociation connector
c88 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 15809659,12917690,12917691,12917689
CYLD interferes with IKK/NF-KappaB signalling by catalysing the selective cleavage of UbLys63 chains from TRAF2, TRAF6 and IKKgamma, without affecting UbLys48-modified IKappaBalpha or Beta-catenin
c89 cso30:c:InputAssociation connector
c90 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
c92 cso30:c:OutputProcess connector
p29_propro_p30
PMID: 15809659,12917690,12917691,12917689
CYLD interferes with IKK/NF-KappaB signalling by catalysing the selective cleavage of UbLys63 chains from TRAF2, TRAF6 and IKKgamma, without affecting UbLys48-modified IKappaBalpha or Beta-catenin
c93 cso30:c:InputAssociation connector
c94 cso30:c:InputProcess connector
c95 cso30:c:OutputProcess connector
c96 cso30:c:OutputProcess connector
p29_propro_p31
PMID: 15809659,12917690,12917691,12917689
CYLD interferes with IKK/NF-KappaB signalling by catalysing the selective cleavage of UbLys63 chains from TRAF2, TRAF6 and IKKgamma, without affecting UbLys48-modified IKappaBalpha or Beta-catenin
c97 cso30:c:InputAssociation connector
c98 cso30:c:InputProcess connector
c99 cso30:c:OutputProcess connector
c100 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 15809659
Figure 2A
PMID: 15809659,10983987
The ubiquitin-like PLIC may provide a link between the ubiquitination machinery and the proteasome
c55 cso30:c:InputProcess connector
c56 cso30:c:InputAssociation connector
c57 cso30:c:OutputProcess connector
c102 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 15809659
Overexpression of CYLD represses NF-KappaB activation in response to various stimuli, including TNF and IL-1.
c101 cso30:c:InputAssociation connector
c103 cso30:c:InputInhibitor connector
c104 cso30:c:InputProcess connector
c105 cso30:c:OutputProcess connector
p32_propro_p33
PMID: 15809659
Overexpression of CYLD represses NF-KappaB activation in response to various stimuli, including TNF and IL-1.
c106 cso30:c:InputAssociation connector
c107 cso30:c:InputProcess connector
c109 cso30:c:InputInhibitor connector
c108 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 15809659,15334086,15258597
The N-terminal ovarian tumour (OTU) domain of A20 contains DUB activity and catalyses the removal of UbLys63 chains from RIP and TRAF6, thereby interfering with TNFR and TLR signalling to IKKs/NF-KappaB, respectively
c110 cso30:c:InputAssociation connector
c111 cso30:c:InputProcess connector
c112 cso30:c:OutputProcess connector
p34_propro_p35
PMID: 15809659,15334086,15258597
The N-terminal ovarian tumour (OTU) domain of A20 contains DUB activity and catalyses the removal of UbLys63 chains from RIP and TRAF6, thereby interfering with TNFR and TLR signalling to IKKs/NF-KappaB, respectively
c113 cso30:c:InputAssociation connector
c114 cso30:c:InputProcess connector
c115 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 15809659,15258597
Subsequently, the C-terminal zinc-finger domain functions as a Ub ligase that mediates UbLys48 modification of RIP and initiates its proteasomal degradation
PMID: 15809659
Figure2B
PMID: 15809659,12753742,15258597
Binding of TNF-alpha to TNFRI induces ubiquitination and degradation of RIP after recruitment to lipid rafts with A20 acting as the potential Ub ligase in this reaction
c116 cso30:c:InputAssociation connector
c117 cso30:c:InputProcess connector
c129 cso30:c:InputAssociation connector
c118 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 15809659,15258597
Subsequently, the C-terminal zinc-finger domain functions as a Ub ligase that mediates UbLys48 modification of RIP and initiates its proteasomal degradation
PMID: 15809659
Figure2B
PMID: 15809659,11907583
TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well
c119 cso30:c:InputProcess connector
c120 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 15809659,11463333
Using sequence similarity, Cezanne and TRAF-binding domain (TRABID) have been isolated as two further potential DUBs that contain OTU domains and can interact with TRAF6
c121 cso30:c:InputProcess connector
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p38_propro_p39
PMID: 15809659,11463333
Using sequence similarity, Cezanne and TRAF-binding domain (TRABID) have been isolated as two further potential DUBs that contain OTU domains and can interact with TRAF6
c124 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 15809659
Ectopic expression of Cezanne downregulates NF-κB, which suggests that Cezanne interferes with IKK activation
c127 cso30:c:InputInhibitor connector
c128 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 15809659,12753742,15258597
Binding of TNF-alpha to TNFRI induces ubiquitination and degradation of RIP after recruitment to lipid rafts with A20 acting as the potential Ub ligase in this reaction
c130 cso30:c:InputProcess connector
c131 cso30:c:InputProcess connector
c132 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 15809659,11907583
TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well
c133 cso30:c:InputAssociation connector
c134 cso30:c:InputProcess connector
c136 cso30:c:InputAssociation connector
c135 cso30:c:OutputProcess connector
p42_propro_p43
PMID: 15809659,11907583
TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well
c137 cso30:c:InputAssociation connector
c138 cso30:c:InputAssociation connector
c139 cso30:c:InputProcess connector
c140 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 15809659
Figure 2B
PMID: 15809659,11907583
TNFRII-dependent process that requires the cellular inhibitor of apoptosis protein (c-IAP1) as a Ub ligase, TRAF2 is polyubiquitinated and degraded as well
c141 cso30:c:InputProcess connector
c142 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 15809659
Both gene products, A20 and c-IAP1, are upregulated by NF-κB, which indicates that an autoregulatory circuit shuts down TNF signalling in a post-inductive manner.
c143 cso30:c:InputAssociation connector
c144 cso30:c:OutputProcess connector
p45_propro_p46
PMID: 15809659
Both gene products, A20 and c-IAP1, are upregulated by NF-κB, which indicates that an autoregulatory circuit shuts down TNF signalling in a post-inductive manner.
c145 cso30:c:InputAssociation connector
c146 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 15809659
Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.
c147 cso30:c:InputAssociation connector
c148 cso30:c:InputProcess connector
c149 cso30:c:OutputProcess connector
p47_propro_p49
PMID: 15809659
Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.
c152 cso30:c:InputAssociation connector
c153 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p47_propro_p52
PMID: 15809659
Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.
c160 cso30:c:InputAssociation connector
c161 cso30:c:InputProcess connector
c162 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 15809659
Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.
c150 cso30:c:InputProcess connector
c151 cso30:c:OutputProcess connector
p47_propro_p51
PMID: 15809659
Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.
c157 cso30:c:InputAssociation connector
c158 cso30:c:InputProcess connector
c159 cso30:c:OutputProcess connector
p53_propro_p48
PMID: 15809659
Itch, the Ub ligase homologue to the E6-AP C-terminal (HECT) domain, and the closely related Nedd4 protein promote ubiquitination and degradation of phospholipase Cgamma1 (PLCgamma1) and PKCdelta, both of which are essential mediators of IKK/NF-KappaB activation in T cells.
c155 cso30:c:InputProcess connector
c156 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 15809659,15082780
Similarly, BCL10, which is downstream of PKCθ on the route to IKKs, is modified by ubiquitination and subsequently degraded after TCR/CD28 costimulation of T cells
c163 cso30:c:InputAssociation connector
c164 cso30:c:InputAssociation connector
c165 cso30:c:InputProcess connector
c166 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 15809659,15082780
Similarly, BCL10, which is downstream of PKCθ on the route to IKKs, is modified by ubiquitination and subsequently degraded after TCR/CD28 costimulation of T cells
c167 cso30:c:InputProcess connector
c168 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 15909659,15340068
p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome
c169 cso30:c:InputProcess connector
c170 cso30:c:InputProcess connector
c171 cso30:c:OutputProcess connector
p55_propro_p56
PMID: 15909659,15340068
p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome
c172 cso30:c:InputProcess connector
c173 cso30:c:InputProcess connector
c174 cso30:c:OutputProcess connector
p55_propro_p57
PMID: 15909659,15340068
p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome
c175 cso30:c:InputProcess connector
c176 cso30:c:InputProcess connector
c177 cso30:c:OutputProcess connector
p55_propro_p58
PMID: 15809659,15340068
p62 interacts through its UBA domain selectively with UbLys63-modified proteins, including TRAF6, while the N-terminal Phox and Bem1 (PB1) region provides a docking surface for the proteasome
c178 cso30:c:InputProcess connector
c179 cso30:c:InputProcess connector
c180 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 15809659,14690596,15226358
After TNF-alpha stimulation, DNA-bound p65 is subject to ubiquitination and proteasomal degradation in the nucleusa process that seems to be required for abrogation of NF-kappaB activity despite IKappaBalpha re-synthesis
c181 cso30:c:InputAssociation connector
c182 cso30:c:InputProcess connector
c183 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 15809659,14690596,15226358
After TNF-alpha stimulation, DNA-bound p65 is subject to ubiquitination and proteasomal degradation in the nucleusa process that seems to be required for abrogation of NF-kappaB activity despite IKappaBalpha re-synthesis
c184 cso30:c:InputProcess connector
c185 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 15809659,14690596
It has also been shown that suppressor of cytokine signalling 1 (SOCS1) associates with p65 in LPS-treated cells; the C-terminal SOCS domain functions as an E3 ligase to catalyse the poly-ubiquitination of p65 and its subsequent degradation
c186 cso30:c:InputProcess connector
c187 cso30:c:InputProcess connector
c189 cso30:c:InputAssociation connector
c188 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 15809659,14690596
It has also been shown that suppressor of cytokine signalling 1 (SOCS1) associates with p65 in LPS-treated cells; the C-terminal SOCS domain functions as an E3 ligase to catalyse the poly-ubiquitination of p65 and its subsequent degradation
c190 cso30:c:InputProcess connector
c191 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 15809659,14690596
It has also been shown that suppressor of cytokine signalling 1 (SOCS1) associates with p65 in LPS-treated cells; the C-terminal SOCS domain functions as an E3 ligase to catalyse the poly-ubiquitination of p65 and its subsequent degradation
c192 cso30:c:InputProcess connector
c193 cso30:c:OutputProcess connector
TNF-alpha:TNFR_enti_e5
TNF-alpha:TNFR
TRAF2_enti_MO000000209
TRAF2
TRAF2{ub}_enti_e6
TRAF2{ub}
RIP_enti_MO000000208
RIP
RIP{ub}_enti_e11
RIP{ub}
Ubc13_enti_MO000022136
Ubc13
JNK_enti_MO000000023
JNK
JNK{active}_enti_e12
JNK{active}
TAK1:TAB2:TAB3_enti_e13
TAK1:TAB2:TAB3
TRAF2{ub}:TAK1:TAB2:TAB3_enti_e14
TRAF2{ub}:TAK1:TAB2:TAB3
RIP{ub}:TAK1:TAB2:TAB3_enti_e15
RIP{ub}:TAK1:TAB2:TAB3
IKKalpha:IKK-beta:IKK-gamma_enti_MO000000248
IKKalpha:IKK-beta:IKK-gamma
IKKalpha:IKKbeta{p}:IKK-gamma_enti_e16
IKKalpha:IKKbeta{p}:IKK-gamma
IL-1:IL-1R_enti_e17
IL-1:IL-1R
Ligand:TLR_enti_e18
Ligand:TLR
TRAF6_enti_MO000000212
TRAF6
TRAF6{ub}_enti_e19
TRAF6{ub}
TIFA_enti_e20
TIFA
TRAF6{ub} oligomer_enti_MO000016963
TRAF6{ub} oligomer
IKKalpha:IKk-beta:IKK-gamma{ub}_enti_e21
IKKalpha:IKk-beta:IKK-gamma{ub}
TRAF6{ub} oligomer:TAK1:TAB2:TAB3_enti_e22
TRAF6{ub} oligomer:TAK1:TAB2:TAB3
IKKalpha:IKk-beta{p}:IKK-gamma{ub}_enti_e23
IKKalpha:IKk-beta{p}:IKK-gamma{ub}
p50:RelA-p65:IkappaB_enti_MO000038724
p50:RelA-p65:IkappaB
p50:RelA-p65:IkappaB{p}_enti_e24
p50:RelA-p65:IkappaB{p}
BetaTRCP_enti_e25
BetaTRCP
p50:RelA-p65:IkappaB{p}{ub}_enti_e26
p50:RelA-p65:IkappaB{p}{ub}
PLIC_enti_e27
PLIC
Ligand:TCR_enti_e29
Ligand:TCR
PKCdelta_enti_MO000000134
PKCdelta
PLCgamma_enti_MO000000102
PLCgamma
PLCgamma{active}_enti_e30
PLCgamma{active}
PKCdelta{active}_enti_e31
PKCdelta{active}
MALT1_enti_MO000063418
MALT1
BCL10_enti_e32
BCL10
CARMA1_enti_e33
CARMA1
BCL10:MALT1:CARMA1_enti_e34
BCL10:MALT1:CARMA1
BCL10:MALT1 oligomer:CARMA1_enti_e35
BCL10:MALT1 oligomer:CARMA1
Nod2_enti_MO000020461
Nod2
Bacteria_enti_e36
Bacteria
Nod2:Bacteria_enti_e37
Nod2:Bacteria
RIP2_enti_MO000017949
RIP2
CYLD_enti_G013179
CYLD
CYLD_enti_MO000041169
CYLD
protein remnants_enti_e10
p50:RelA-p65{active}_enti_MO000016632
p50:RelA-p65{active}
A20_enti_MO000016591
A20
Cezanne_enti_e28
Cezanne
TRABID_enti_e38
TRABID
TRAF6:Cezanna_enti_e39
TRAF6:Cezanna
TRAF6:TRABID_enti_e40
TRAF6:TRABID
NF-KappaB_enti_e42
NF-KappaB
TNF-alpha_enti_MO000000289
TNF-alpha
TNFR1_enti_e41
TNFR1
TNFRII_enti_e43
TNFRII
c-IAP1_enti_e44
c-IAP1
A20_enti_G010405
A20
c-IAP1_enti_e45
c-IAP1
Itch_enti_MO000038234
Itch
PLCgamma{ub}_enti_e46
PLCgamma{ub}
PKCdelta{ub}_enti_e47
PKCdelta{ub}
Nedd4_enti_MO000017913
Nedd4
Ligand:CD28_enti_e48
Ligand:CD28
BCL10{ub}_enti_e49
BCL10{ub}
p62_enti_MO000022281
p62
p62:IKK-alpha:IKK-beta:IKK-gamma{uba]_enti_e63
p62:IKK-alpha:IKK-beta:IKK-gamma{uba]
p62:RIP{ub}_enti_e64
p62:RIP{ub}
TRAF2{ub}:p62_enti_e65
TRAF2{ub}:p62
TRAF6{ub}:p62_enti_e66
TRAF6{ub}:p62
RelA-p65:DNA_enti_e67
RelA-p65:DNA
RelA-p65{ub}:DNA_enti_e68
RelA-p65{ub}:DNA
protein degradants_enti_e69
SOCS-1_enti_MO000017004
SOCS-1
SOCS-1:p50:RelA-p65{active}_enti_e70
SOCS-1:p50:RelA-p65{active}
LPS_enti_MO000016882
LPS
SOCS-1:p50:RelA-p65{ub}_enti_e71
SOCS-1:p50:RelA-p65{ub}