1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15876435.csml convertedTime:2009.07.02.15:36

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Adaptor usage and Toll-like receptor signaling specificity.
Authors Dunne A, O'Neill LA.
Affiliation Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland.aidunne@tcd.ie
Abstract It is now well established that Toll-like receptors (TLRs) act as primarysensors of microbial compounds. Details of the molecular mechanisms governingTLR responses are emerging steadily and our understanding of the signalingpathways activated these receptors has improved greatly over the last few years.Differences in adaptor usage, cellular localisation and signaling cascades havebeen elucidated. In this review we will summarize the current understanding ofTLR signaling and its regulation.
PMID 15876435
Model Abstract

Entity

G010228:IFN-beta MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000058:NF-kappaB{active} MO000000065:RIP1 MO000000166:Rac1 MO000000212:TRAF6 MO000000248:IKK MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000016569:IRAK-M MO000016573:MyD88 MO000016591:A20 MO000016608:IKK-i MO000016882:LPS MO000016916:MKK7 MO000017426:fibrinogen MO000017549:fibronectin MO000019005:MKK6 MO000019331:TBK1 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000019479:protein remnants MO000020119:Hsp60 MO000021614:Hsp70 MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 e1: e10: e11:Hsp60:TLR4 e12:HSP70:TLR4 e13:fibronectin:TLR4 e14:(LPS:TLR4)2 e15:(LPS:TLR4)2:TIRAP e16:(LPS:TLR4)2:TIRAP:MYD88 e17:(LPS:TLR4)2:TIRAP:MYD88:IRAK4 e18:IRAK1 e19:(LPS:TLR4)2:TIRAP:MYD88:IRAK4:IRAK1 e2: e20:(LPS:TLR4)2:TIRAP:MYD88:IRAK4:IRAK1{p} e21:IRAK1{p}:TRAF6 e22:IRAK1{p}:TRAF6 e23:TAK1:TAB1:TAB2 {active} e24:TAK1:TAB1:TAB2 e25:IKK{p} e26:NF-kappaB e27:MKK6{p} e28:MKK7{p} e29:p38{active} e3: e30:JNK{active} e31:(LPS:TLR4)2:TRAM e32:(LPS:TLR4)2:TRAM:TRIF e33:(LPS:TLR4)2:TRAM:TRIF:TRAF6 e34:(LPS:TLR4)2:TRAM:TRIF:TBK1:IKK-i e35:(LPS:TLR4)2:TRAM:TRIF:RIP1 e36:IRF-3{active} e37:TLR1:TLR2 e38:TLR2:TLR6 e39:triacyl lipopeptide e4: e40:triacyl lipopeptide:TLR1:TLR2 e41:diacyl lipopeptide e42:diacyl lipopeptide:TLR2:TLR6 e43:diacyl lipopeptide:TLR2{p}:TLR6 e44:diacyl lipopeptide:TLR2{p}:TLR6:PI3K e45:diacyl lipopeptide:TLR2{p}:TLR6:PI3K:Rac1 e46:(LPS:TLR4):TIRAP:MYD88:PI3K e47:ssRNA:TLR7 e48:flagellin:TLR5 e49: e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:fibrinogen:TLR4 e60: e61: e62: e63: e64: e65:CpG DNA:TLR9 e66:CpG DNA e67:RNA e68:IFN-alpha e69:dsRNA:TLR3{p}:TRIF:PI3K e7: e70:dsRNA:TLR3:TRIF:RIP1 e71:dsRNA:TLR3:TRIF:TBK1:IKK-i:NAP1 e72:NAP1 e73:dsRNA:TLR3{p} e74:CpG DNA:TLR9:IRF7:MYD88:TRAF6 e75:ssRNA:TLR7:MYD88:TRAF6:IRF5 e76:MYD88s e77:(LPS:TLR4)2:TIRAP:MYD88:IRAK4 e78:IRAK1{p} e79:ubiquitin e8: e80:Triad3A e81:Triad3A{ub} e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p7 p8 p9
Model Detail
801.0, 1269.0
38.0, 38.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
918.0, 1090.0
28.0, 28.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
672.0, 1016.0
32.0, 32.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
572.0, 336.0
32.0, 32.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p35 p43

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1206.0, 1514.0
36.0, 36.0

NF-kappaB{active}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p26 p45

--

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
801.0, 345.0
38.0, 38.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p44

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
393.0, 341.0
30.0, 30.0

Rac1

--

MO000000166

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m146

10

false

infinite

0

unit false false false
TRANSPATHMO000000166

--

Go back
1267.0, 1015.0
34.0, 34.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p23 p49 p54

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1132.0, 1160.5
31.5, 31.5

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
881.0, 445.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p47

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
427.0, 483.0
34.0, 34.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
396.0, 888.0
32.0, 32.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p51 p52 p53

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1107.0, 727.0
34.0, 34.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p55

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
1284.0, 656.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p49 p54

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1276.0, 1344.0
32.0, 32.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
946.0, 342.0
27.0, 27.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p46 p53

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1586.0, 458.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
826.0, 934.0
32.0, 32.0

MKK7

--

MO000016916

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1831

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016916

--

Go back
1562.0, 366.0
30.0, 30.0

fibrinogen

--

MO000017426

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m2254

10

false

infinite

0

unit false false false
TRANSPATHMO000017426

--

Go back
1210.0, 102.0
36.0, 36.0

fibronectin

--

MO000017549

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m2341

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017549

--

Go back
1059.0, 907.0
33.0, 33.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
890.0, 342.0
28.0, 28.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p46 p52

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1331.0, 394.5
42.5, 42.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4 p5 p1 p2 p57

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
687.0, 263.0
33.0, 33.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
639.0, 263.0
34.0, 34.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p29

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
615.0, 563.0
34.0, 34.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p58

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
309.0, 477.0
38.0, 38.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p60

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
539.0, 263.0
34.0, 34.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
1211.0, 507.0
34.0, 34.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57 p58 p59 p60

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1539.0, 263.0
34.0, 34.0

Hsp60

--

MO000020119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m4645

10

false

infinite

0

unit false false false
InterProIPR002423
TRANSPATHMO000020119

--

Go back
1423.0, 135.0
34.0, 34.0

Hsp70

--

MO000021614

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m5956

10

false

infinite

0

unit false false false
InterProIPR001023
TRANSPATHMO000021614

--

Go back
124.0, 488.0
40.0, 40.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
794.0, 566.0
27.0, 27.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1294.0, 578.0
28.0, 28.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1285.0, 745.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1075.0, 339.0
34.0, 34.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p43

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1123.0, 331.0
34.0, 34.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
664.0, 592.0
31.0, 31.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
437.0, 1053.0
38.0, 38.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51 p52 p53

--

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
521.0, 717.0
29.0, 29.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p59

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
545.0, 553.0
30.0, 30.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
279.46792708799154, 256.3527626037644
1120.6433906146556, 1627.1742031724766

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
290.26524812872844, 281.2233668452449
1086.2466161874277, 1528.043553188087

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1314.5, 252.95921946941456
27.921069940802454, 54.0407805305854

Hsp60:TLR4

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1258.5, 252.95921946941456
27.921069940802454, 54.0407805305854

HSP70:TLR4

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1206.5, 253.64306073229557
27.051085288313963, 52.35693926770445

fibronectin:TLR4

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1346.5, 530.4716071037053
26.10633632975225, 50.528392896294676

(LPS:TLR4)2

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1342.0, 621.5588235294118
27.26470588235294, 45.44117647058824

(LPS:TLR4)2:TIRAP

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1341.0, 687.5882352941177
29.647058823529406, 49.41176470588236

(LPS:TLR4)2:TIRAP:MYD88

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1346.0, 776.6470588235294
28.411764705882348, 47.35294117647059

(LPS:TLR4)2:TIRAP:MYD88:IRAK4

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1195.0, 812.2999999999998
41.599999999999994, 31.2

IRAK1

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p51

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1352.0, 864.7352941176471
23.558823529411764, 39.26470588235295

(LPS:TLR4)2:TIRAP:MYD88:IRAK4:IRAK1

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
279.46792708799154, 256.3527626037644
1120.6433906146556, 1627.1742031724766

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1340.0, 915.3823529411766
24.970588235294116, 41.617647058823536

(LPS:TLR4)2:TIRAP:MYD88:IRAK4:IRAK1{p}

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1340.0, 1066.2541436464087
32.171270718232044, 35.74585635359116

IRAK1{p}:TRAF6

--

e21

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1328.0, 1144.7431770468859
40.76976906927922, 31.25682295311406

IRAK1{p}:TRAF6

--

e22

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1230.5, 1057.3637364654066
26.972655533125348, 37.63626353459351

TAK1:TAB1:TAB2 {active}

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1276.5, 1198.6069003486878
30.38172141677372, 42.39309965131218

TAK1:TAB1:TAB2

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1184.0, 1284.5
31.5, 31.5

IKK{p}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1162.0, 1370.0
36.0, 36.0

NF-kappaB

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p26 p45

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1064.0, 1060.0
31.0, 31.0

MKK6{p}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
788.0, 976.0
32.0, 32.0

MKK7{p}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016916

--

Go back
1018.0, 1162.0
28.0, 28.0

p38{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
301.8807949002848, 278.76563041605743
1075.8176549900688, 1582.3484675478915

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
764.0, 1100.0
32.0, 32.0

JNK{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1080.5, 258.46173609836666
31.20242246283721, 43.538263901633336

(LPS:TLR4)2:TRAM

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1006.0, 253.41176470588243
27.352941176470587, 45.58823529411765

(LPS:TLR4)2:TRAM:TRIF

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
949.0, 247.44117647058806
29.73529411764705, 49.558823529411754

(LPS:TLR4)2:TRAM:TRIF:TRAF6

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
855.0, 253.29411764705884
26.823529411764703, 44.70588235294118

(LPS:TLR4)2:TRAM:TRIF:TBK1:IKK-i

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
736.0, 254.23529411764707
31.05882352941176, 51.76470588235294

(LPS:TLR4)2:TRAM:TRIF:RIP1

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
937.0, 585.0
30.0, 30.0

IRF-3{active}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27 p47

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
587.5, 260.6565572404599
32.130478253624396, 39.34344275954007

TLR1:TLR2

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
490.5, 263.58540243292805
26.471921346442265, 32.414597567072164

TLR2:TLR6

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
485.0, 80.07436103843816
37.9875226403703, 23.42563896156168

triacyl lipopeptide

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
343.3446003530268, 317.9881490875704
992.8900440845848, 1503.9034302048642

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
454.5, 256.89025509267776
27.311983850247753, 38.10974490732245

triacyl lipopeptide:TLR1:TLR2

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
596.0, 68.28506741799151
39.267458241094786, 24.214932582008455

diacyl lipopeptide

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
409.5, 255.28959442099494
29.892457331620488, 41.71040557900532

diacyl lipopeptide:TLR2:TLR6

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
372.5, 254.6158928243716
31.091943475867136, 43.38410717562857

diacyl lipopeptide:TLR2{p}:TLR6

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
310.0, 283.76470588235304
28.941176470588232, 48.235294117647065

diacyl lipopeptide:TLR2{p}:TLR6:PI3K

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
315.0, 353.7352941176471
26.558823529411757, 44.26470588235294

diacyl lipopeptide:TLR2{p}:TLR6:PI3K:Rac1

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
309.0, 410.8529411764706
30.08823529411764, 50.14705882352941

(LPS:TLR4):TIRAP:MYD88:PI3K

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
522.5, 581.6956807717605
27.0238982679237, 52.304319228239414

ssRNA:TLR7

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
310.5, 537.4722648541986
27.65599649199737, 53.527735145801365

flagellin:TLR5

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
520.0, 558.0
208.99334382644616, 348.9126163882194

--

e49

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false true false

--

Go back
1347.5, 456.9708397281298
24.298399473799606, 47.029160271870204

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p1

p7

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
516.6817984375136, 1194.7421652009216
609.4270677524557, 552.6833929151696

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
582.5044612487658, 1207.8399581377387
356.35027797815854, 535.6602904639835

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
524.6259129147339, 1202.1188429297686
593.5388387980156, 537.9300374574748

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
525.7607864114796, 1203.2537164265152
591.269091804524, 535.6602904639835

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
516.6817984375136, 1194.7421652009216
609.4270677524557, 552.6833929151696

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
516.6817984375136, 1194.7421652009216
609.4270677524557, 552.6833929151696

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
525.7607864114796, 1203.2537164265152
591.269091804524, 535.6602904639835

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
961.5522091618388, 1421.7168645500678
38.07365469366693, 34.466676880582725

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
861.6833414482144, 1580.599154094468
107.81298219084412, 97.59912072013263

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
516.6817984375136, 1194.7421652009216
609.4270677524557, 552.6833929151696

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1354.5, 321.69568077176064
27.023898267923702, 52.304319228239414

fibrinogen:TLR4

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
660.3203292966817, 1440.3500981519496
19.299659776706687, 9.292428781377296

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
659.6758590274758, 1412.637876576101
66.05820259359567, 118.9047646684721

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
687.3880806033259, 1489.9743088807977
10.311524307292963, 10.311524307292961

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
520.0, 558.0
208.99334382644616, 348.9126163882194

--

e63

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false true false

--

Go back
520.0, 558.0
208.99334382644616, 348.9126163882194

--

e64

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false true false

--

Go back
516.5, 765.9581232185924
22.891471168603378, 44.30607322955492

CpG DNA:TLR9

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
418.0, 673.5
60.0, 13.0

CpG DNA

--

e66

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
384.0, 570.2660600745451
39.16246437184827, 20.23393992545494

RNA

--

e67

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
677.0, 1363.501730103806
45.93425605536332, 24.498269896193772

IFN-alpha

--

e68

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p41 p42 p50

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
711.5, 674.235639566893
25.63112497706001, 35.764360433106994

dsRNA:TLR3{p}:TRIF:PI3K

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
294.19154668899614, 262.900640230661
1099.0020312344216, 1557.257490752832

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
716.0, 720.5882352941177
23.64705882352941, 39.411764705882355

dsRNA:TLR3:TRIF:RIP1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
705.0, 781.2058823529411
22.676470588235297, 37.79411764705882

dsRNA:TLR3:TRIF:TBK1:IKK-i:NAP1

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
861.0, 720.2158381968203
37.75810022137251, 23.28416180317971

NAP1

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
692.0, 635.3414634146343
32.07317073170732, 25.65853658536586

dsRNA:TLR3{p}

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
619.0, 873.1470588235292
26.911764705882355, 44.85294117647059

CpG DNA:TLR9:IRF7:MYD88:TRAF6

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
513.0, 649.3529411764706
22.588235294117645, 37.64705882352941

ssRNA:TLR7:MYD88:TRAF6:IRF5

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1166.5, 753.402092976454
25.65204266452002, 41.59790702354599

MYD88s

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p11

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1339.5, 982.7861993026245
25.236557166452556, 35.21380069737567

(LPS:TLR4)2:TIRAP:MYD88:IRAK4

--

e77

cso30:c:Complex

cso30:i:CC_Extracellular

--

p55

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1130.0, 869.8292682926829
36.46341463414634, 29.17073170731707

IRAK1{p}

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1262.0, 1290.0
32.0, 32.0

ubiquitin

--

e79

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p56

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
298.1178452492641, 290.38473015253663
1054.2857440190214, 1530.8229003156168

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1097.0, 491.46772684752113
21.463985032740876, 49.53227315247894

Triad3A

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1059.0, 402.668299510147
34.34569629111266, 26.33170048985304

Triad3A{ub}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p61

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
308.5879747433122, 317.86882007441244
1049.472351285583, 1510.7465415674894

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1501.0, 461.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c1 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 15876435, 9851930 The most compelling evidence that LPS was acting through TLR4 came from studies on a strain of mice called the C3H/HeJ mice. These mice have a point mutation in the gene encoding TLR4 that renders them hyporesponsive to LPS challenge.

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1483.0, 827.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c161 : 1
stoichiometry:c29 : 1

m17*m18*0.1

nodelay

--

true

0

false

PMID: 15876435, 14625308 IRAK-4 is thought to function upstream of IRAK-1 and has been shown to phosphorylate IRAK-1 in vitro. PMID: 15876435 A splice variant of MyD88, termed MyD88s, also inhibits LPS/IL-1 induced NF-¦ÊB activity by preventing the association of IRAK-1 with IRAK-4 and the subsequent activation of IRAK-1.

Go back
1486.0, 925.5
20.5, 20.5

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c162 : 1
stoichiometry:c31 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15876435, 14625308 IRAK-4 is thought to function upstream of IRAK-1 and has been shown to phosphorylate IRAK-1 in vitro. PMID: 15876435 A splice variant of MyD88, termed MyD88s, also inhibits LPS/IL-1 induced NF-¦ÊB activity by preventing the association of IRAK-1 with IRAK-4 and the subsequent activation of IRAK-1.

Go back
1497.0, 1021.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c32 : 1
stoichiometry:c167 : 1
stoichiometry:c34 : 1

m183*m83*0.1

nodelay

--

true

0

false

PMID: 15876435, 8837778 Upon activation, IRAK-1 engages with tumor necrosis factor (TNF)-receptor-associated factor 6 (TRAF6), a member of the TRAF family of proteins. PMID: 15876435 IRAK-M, a kinase inactive IRAK family member, prevents the disssociation of IRAK-1 from MyD88 and the subsequent association of IRAK-1 with the downstream adaptor TRAF6.

Go back
1455.0, 1155.0
25.0, 25.0

p13

p13

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 15876435, 11057907 TRAF6 undergoes ubiquitination following cell stimulation and that TRAF6 itself is a ubiquitin ligase.

Go back
1280.0, 1132.0
23.0, 23.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 15876435, 11460167 Once ubiquitinated, TRAF6 activates IKK through a TAK1-TAB1-TAB2 kinase complex.

Go back
1190.0, 1242.0
20.0, 20.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m207*m23*0.1

nodelay

--

true

0

false

PMID: 15876435 Once activated, TAK1 phosphorylates the activation loop of IKK¦Â, thereby activating the IKK complex and the pleiotropic transcription factor, NF-¦ÊB.

Go back
1215.0, 1434.5
18.5, 18.5

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m27*m25*0.1

nodelay

--

true

0

false

PMID: 15876435 Once activated, TAK1 phosphorylates the activation loop of IKK¦Â, thereby activating the IKK complex and the pleiotropic transcription factor, NF-¦ÊB.

Go back
1068.0, 980.0
23.0, 23.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m3613*m23*0.1

nodelay

--

true

0

false

PMID: 15876435, 11460167 TAK1 also phosphorylates MKK6 and 7, which in turn activate the p38 and JNK kinase pathways, respectively.

Go back
885.0, 981.0
21.0, 21.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m1831*m23*0.1

nodelay

--

true

0

false

PMID: 15876435, 11460167 TAK1 also phosphorylates MKK6 and 7, which in turn activate the p38 and JNK kinase pathways, respectively.

Go back
998.0, 1110.0
19.0, 19.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m30*m28*0.1

nodelay

--

true

0

false

PMID: 15876435, 11460167 TAK1 also phosphorylates MKK6 and 7, which in turn activate the p38 and JNK kinase pathways, respectively.

Go back
1479.0, 371.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3961*m2254*0.1

nodelay

--

true

0

false

PMID: 15876435, 15790348 It later emerged that TLR4 is also a receptor for endogenous ligands such as fibrinogen, heat shock proteins (HSP 60 and HSP 70), fibronectins and hyaluronic acid.

Go back
751.0, 1055.0
17.0, 17.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m32*m29*0.1

nodelay

--

true

0

false

PMID: 15876435, 11460167 TAK1 also phosphorylates MKK6 and 7, which in turn activate the p38 and JNK kinase pathways, respectively.

Go back
1128.0, 184.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m19005*m14*0.1

nodelay

--

true

0

false

PMID: 15876435 TRAM, like Mal, acts as a bridge to couple TRIF to TLR4 and is absolutely required for TLR4 mediated responses.

Go back
1042.0, 166.0
19.0, 19.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m34*m18998*0.1

nodelay

--

true

0

false

PMID: 15876435 TRAM, like Mal, acts as a bridge to couple TRIF to TLR4 and is absolutely required for TLR4 mediated responses.

Go back
1137.0, 397.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m35*m183*0.1

nodelay

--

true

0

false

PMID: 15876435 The N-terminus of TRIF contains binding sites for TRAF6 and the non-canonical kinases IKKi and TBK1, the TIR domain presumably tethers TRIF to its binding partner TRAM and finally the C-terminus of TRIF contains a RIP-1 binding site.

Go back
886.0, 174.0
19.0, 19.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c67 : 1
stoichiometry:c70 : 1

m1599*m3902*m35*0.1

nodelay

--

true

0

false

PMID: 15876435 The N-terminus of TRIF contains binding sites for TRAF6 and the non-canonical kinases IKKi and TBK1, the TIR domain presumably tethers TRIF to its binding partner TRAM and finally the C-terminus of TRIF contains a RIP-1 binding site.

Go back
801.0, 169.0
21.0, 21.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c71 : 1
stoichiometry:c73 : 1

m38*m36*0.1

nodelay

--

true

0

false

PMID: 15876435 The N-terminus of TRIF contains binding sites for TRAF6 and the non-canonical kinases IKKi and TBK1, the TIR domain presumably tethers TRIF to its binding partner TRAM and finally the C-terminus of TRIF contains a RIP-1 binding site.

Go back
1178.0, 1446.0
19.0, 19.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m27*m39*0.1

nodelay

--

true

0

false

PMID: 15876435 Both TRAF6 and RIP-1 are thought to mediate TRIF induced NF-¦ÊB activation whereas IKKi and TBK1 are required for TRIF-induced IRF-3 activation.

Go back
1021.0, 501.0
21.0, 21.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c78 : 1

m977*m37*0.1

nodelay

--

true

0

false

PMID: 15876435 Both TRAF6 and RIP-1 are thought to mediate TRIF induced NF-¦ÊB activation whereas IKKi and TBK1 are required for TRIF-induced IRF-3 activation.

Go back
646.0, 186.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m3964*m3963*0.1

nodelay

--

true

0

false

PMID: 15876435 The ability of TLR2 to recognize such a wide range of compounds has been attributed to the ability of TLR2 to heterodimerize with other TLRs, namely TLR1 and TLR6.

Go back
584.0, 192.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 15876435 The ability of TLR2 to recognize such a wide range of compounds has been attributed to the ability of TLR2 to heterodimerize with other TLRs, namely TLR1 and TLR6.

Go back
1482.0, 290.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3961*m4645*0.1

nodelay

--

true

0

false

Go back
494.0, 150.0
19.0, 19.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m41*m43*0.1

nodelay

--

true

0

false

--

Go back
561.0, 133.0
21.0, 21.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m45*m42*0.1

nodelay

--

true

0

false

PMID: 15876435, 12077222, 11431423 The association of TLR2 with TLR1 permits the recognition of triacyl lipopeptides whereas TLR2/TLR6 heterodimers recognize diacyl lipopeptides.

Go back
392.0, 184.0
23.0, 23.0

p32

p32

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 15876435, 11101877 Biochemical studies with heat-killed Staphylococcus aureus (HKSA) have demonstrated that phosphorylation of TLR2 on specific tyrosine residues facilitates the recruitment of PI3K, an effector of the small G-protein, Rac-1.

Go back
308.0, 180.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m47*m48*0.1

nodelay

--

true

0

false

PMID: 15876435, 11101877 Biochemical studies with heat-killed Staphylococcus aureus (HKSA) have demonstrated that phosphorylation of TLR2 on specific tyrosine residues facilitates the recruitment of PI3K, an effector of the small G-protein, Rac-1. PMID: 15876435 The p85 subunit of PI3K binds to phospho-tyrosine residues via a src-homology domain.

Go back
200.0, 332.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m49*m146*0.1

nodelay

--

true

0

false

PMID: 15876435 The p85 subunit of PI3K binds to phospho-tyrosine residues via a src-homology domain. Phosphorylation of TLR2 by an as yet unidentified kinase induces the formation of an active TLR2?Rac1?PI3K complex.

Go back
1217.0, 613.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m16*m48*0.1

nodelay

--

true

0

false

PMID: 15876435 PI3K does not bind directly to TLR4 but rather interacts with TLR4 through MyD88.

Go back
218.0, 497.5
20.5, 20.5

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c180 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 15876435, 11323673 TLR5 recognizes flagellin, a monomeric constituent of bacterial flagella.

Go back
696.0, 556.0
23.0, 23.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 15876435 TLR3 is highly expressed in macrophages, dendritic cells and epithelial cells and induces the expression of IFN-¦Â following exposure to double stranded (d/s) RNA.

Go back
809.0, 1225.0
21.0, 21.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 15876435 TLR3 is highly expressed in macrophages, dendritic cells and epithelial cells and induces the expression of IFN-¦Â following exposure to double stranded (d/s) RNA.

Go back
458.0, 569.5
20.5, 20.5

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c115 : 1
stoichiometry:c111 : 1

m19940*m72*0.1

nodelay

--

true

0

false

PMID: 15876435 TLRs 7 and 9 are expressed in a subset of DCs called plasmacytoid DCs or pre-DC2 cells. Exposure of these cells to ssRNA or DNA from viral genomes results in the secretion of large amounts of IFN-alpha.

Go back
1340.0, 184.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3961*m5956*0.1

nodelay

--

true

0

false

PMID: 15876435, 15790348 It later emerged that TLR4 is also a receptor for endogenous ligands such as fibrinogen, heat shock proteins (HSP 60 and HSP 70), fibronectins and hyaluronic acid.

Go back
452.0, 720.5
23.5, 23.5

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m19828*m71*0.1

nodelay

--

true

0

false

PMID: 15876435 TLRs 7 and 9 are expressed in a subset of DCs called plasmacytoid DCs or pre-DC2 cells. Exposure of these cells to ssRNA or DNA from viral genomes results in the secretion of large amounts of IFN-alpha.

Go back
688.0, 1260.0
23.0, 23.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 15876435 TLRs 7 and 9 are expressed in a subset of DCs called plasmacytoid DCs or pre-DC2 cells. Exposure of these cells to ssRNA or DNA from viral genomes results in the secretion of large amounts of IFN-alpha.

Go back
645.0, 1273.0
21.0, 21.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 15876435 TLRs 7 and 9 are expressed in a subset of DCs called plasmacytoid DCs or pre-DC2 cells. Exposure of these cells to ssRNA or DNA from viral genomes results in the secretion of large amounts of IFN-alpha.

Go back
773.0, 636.5
22.5, 22.5

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c122 : 1

m18998*m78*m48*0.1

nodelay

--

true

0

false

PMID: 15876435 TLR3 functions independently of MyD88 requiring only the adaptor TRIF to transmit signals to the nucleus. PMID: 15876435 phosphorylated TLR3 recruits both TRIF and PI3K.

Go back
809.0, 657.0
21.0, 21.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m74*m38*0.1

nodelay

--

true

0

false

PMID: 15876435 TLR3 can activate NF-¦ÊB to some extent and this is thought to be mediated by the interaction of RIP1 with TRIF.

Go back
1252.0, 1392.5
15.5, 15.5

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m27*m75*0.1

nodelay

--

true

0

false

PMID: 15876435 TLR3 can activate NF-¦ÊB to some extent and this is thought to be mediated by the interaction of RIP1 with TRIF.

Go back
802.0, 722.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c136 : 1
stoichiometry:c132 : 1

m74*m3902*m1599*m77*0.1

nodelay

--

true

0

false

PMID: 15876435 As described for TLR4, TRIF also recruits the kinases TBK1 and IKKi to activate IRF-3. PMID: 15876435 TANK homolog, NAP1 (NF-¦ÊB-activating kinase (NAK)-associated protein 1) that forms a functional complex with TBK1 and IKKi rather than TANK itself.

Go back
925.0, 517.0
21.0, 21.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m977*m76*0.1

nodelay

--

true

0

false

PMID: 15876435 As described for TLR4, TRIF also recruits the kinases TBK1 and IKKi to activate IRF-3. PMID: 15876435 TRIF in turn recruits the kinase complex NAP1/IKKi /TBK1 leading to partial IRF3 phosphorylation.

Go back
734.0, 598.0
19.0, 19.0

p48

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c137 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 15876435 phosphorylated TLR3 recruits both TRIF and PI3K.

Go back
457.0, 825.0
21.0, 21.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m980*m1572*m183*m70*0.1

nodelay

--

true

0

false

PMID: 15876435, 15361868 MyD88 and TRAF6 directly associate with IRF7 to induce IFN-alpha following stimulation of cells with ligands for TLR7 and TLR9.

Go back
1205.0, 173.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m2341*m3961*0.1

nodelay

--

true

0

false

Go back
594.0, 1318.0
19.0, 19.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c145 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 15876435, 15361868 MyD88 and TRAF6 directly associate with IRF7 to induce IFN- alpha following stimulation of cells with ligands for TLR7 and TLR9.

Go back
446.0, 965.5
20.5, 20.5

p51

p51

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m980*m18*0.1

nodelay

--

true

0

false

PMID: 15876435, 15361868 IRAK-1 also participates in the activation of IRF-7 possibly through direct phosphorylation as suggested by in vitro kinase assays.

Go back
398.0, 978.0
19.0, 19.0

p52

p52

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m980*m3902*0.1

nodelay

--

true

0

false

PMID: 15876435, 12692549 It should be noted however that TBK1 and IKKi have also been shown to phosphorylate IRF-7.

Go back
485.0, 925.0
21.0, 21.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m980*m1599*0.1

nodelay

--

true

0

false

PMID: 15876435, 12692549 It should be noted however that TBK1 and IKKi have also been shown to phosphorylate IRF-7.

Go back
494.0, 510.0
19.0, 19.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m65*m979*m1572*m183*0.1

nodelay

--

true

0

false

PMID: 15876435, 15695821, 15665823 IRF5 complexes with both MyD88 and TRAF6 and IRF-5, like IRF-7, is activated by TLR7 and TLR8.

Go back
1189.0, 925.0
21.0, 21.0

p55

p55

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c166 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15876435 IRAK-M, a kinase inactive IRAK family member, prevents the disssociation of IRAK-1 from MyD88 and the subsequent association of IRAK-1 with the downstream adaptor TRAF6.

Go back
1461.0, 1237.0
21.0, 21.0

p56

p56

cso30:i:ME_Deubiquitination

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c170 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m22*m1585*0.1

nodelay

--

true

0

false

PMID: 15876435, 15361868 the deubiquitinating enzyme, A20, returns TRAF6 to an unmodified state and in doing so terminates TLR responses.

Go back
1217.0, 405.0
22.0, 22.0

p57

p57

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1

m3961*m85*0.1

nodelay

--

true

0

false

PMID: 15876435, 15107846 Triad3A, a novel RING-type E3 ubiquitin-ligase was recently shown to promote the degradation of TLR3, TLR4, TLR5 and TLR9 but not TLR2.

Go back
965.0, 649.0
21.0, 21.0

p58

p58

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c176 : 1
stoichiometry:c175 : 1

m3965*m85*0.1

nodelay

--

true

0

false

PMID: 15876435, 15107846 Triad3A, a novel RING-type E3 ubiquitin-ligase was recently shown to promote the degradation of TLR3, TLR4, TLR5 and TLR9 but not TLR2.

Go back
973.0, 765.0
21.0, 21.0

p59

p59

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c179 : 1
stoichiometry:c178 : 1

m19828*m85*0.1

nodelay

--

true

0

false

PMID: 15876435, 15107846 Triad3A, a novel RING-type E3 ubiquitin-ligase was recently shown to promote the degradation of TLR3, TLR4, TLR5 and TLR9 but not TLR2.

Go back
1472.0, 579.5
24.5, 24.5

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m14*m6810*0.1

nodelay

--

true

0

false

PMID: 15876435 Unlike MyD88, Mal is not required for IL-1 signaling and its role in TLR4 signaling appears to be structural one, acting as a bridge to couple MyD88 to TLR4.

Go back
873.0, 846.0
21.0, 21.0

p60

p60

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c182 : 1

m3966*m85*0.1

nodelay

--

true

0

false

PMID: 15876435, 15107846 Triad3A, a novel RING-type E3 ubiquitin-ligase was recently shown to promote the degradation of TLR3, TLR4, TLR5 and TLR9 but not TLR2.

Go back
1062.0, 458.0
19.0, 19.0

p61

p61

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 15876435 Triad3A was also found to undergo autoubiqutination similar to TRAF6.

Go back
1465.0, 532.5
22.5, 22.5

p7

p7

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15876435 Following exposure of cells to LPS, TLR4 homodimerizes and recruits two sets of adaptor molecules.

Go back
1477.0, 661.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 15876435 Unlike MyD88, Mal is not required for IL-1 signaling and its role in TLR4 signaling appears to be structural one, acting as a bridge to couple MyD88 to TLR4.

Go back
1485.0, 749.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m16*m17258*0.1

nodelay

--

true

0

false

PMID: 15876435 MyD88 differs from Mal in that it also possesses an N-terminal death domain. This domain serves to recruit members of the IL-1 receptor associated kinase (IRAK) family of which there are four. PMID: 15876435, 14625308 IRAK-4 is thought to function upstream of IRAK-1 and has been shown to phosphorylate IRAK-1 in vitro.

Go back
1379.993997508121, 474.0

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1352.0, 215.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1244.5867327198941, 635.5403691564318

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 359.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.831694907432, 440.63234643287024

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
246.9346862024594, 498.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
164.0, 508.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 571.1784904247103

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.5536798306425, 579.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.9430147078954, 569.9531617649475

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 1246.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0, 623.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1370.1554175279994, 160.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.9266413443544, 570.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.0, 584.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.0, 732.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 742.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 687.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 580.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.0, 1283.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 634.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.0, 1294.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 810.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1291.5047326640743, 207.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.0, 608.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.8005145193887, 372.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.485433827199, 656.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.0, 672.9402850002907

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 383.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.3000400080607, 677.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.0, 1391.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1231.1110982791802, 1408.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0, 754.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
737.0, 698.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1219.5689290811056, 138.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.919512537665, 370.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.9310898026827, 369.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.5039238887392, 739.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.0, 475.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 538.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 544.2273043158026

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
829.0, 732.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.4929882637098, 617.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0, 648.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 368.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1216.0, 194.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.0, 852.145770236779

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.848738235319, 675.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.77766446178924, 839.8729483494803

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.0, 840.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.2625860380489, 797.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.0, 1332.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.5189049686614, 918.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
422.0, 920.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 986.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.85202361494646, 832.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1226.024550284402, 200.91397100140864

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.4132406834243, 920.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 997.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.93799916073334, 370.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.0, 910.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.2262082614183, 946.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.99893020551156, 369.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.6996903666365, 536.5307152332491

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 506.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.8584407682138, 523.498301936352

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.6876203461624, 530.3904138877326

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1372.0, 487.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 529.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.0, 777.0

c161

c161

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1192.0, 781.0

c162

c162

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1218.0, 936.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1210.0, 940.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1168.6568542494924, 904.6568542494924

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1131.0, 761.0

c166

c166

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1141.0, 757.0

c167

c167

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1301.6638721925524, 1251.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1373.603947249397, 1108.5424513544062

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1380.9531557045557, 545.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1308.0, 1259.2200086007604

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1247.0, 416.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1228.0, 427.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1118.0, 430.10308856079376

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.0, 584.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 536.8132855935488

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
991.4080028723301, 528.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 733.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 546.745522973921

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.4493835293495, 539.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1373.0, 560.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
239.0, 514.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
347.0, 508.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 545.565484912661

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.3981083113158, 533.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1083.8, 483.4

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1073.0, 436.9810426273839

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1322.0, 592.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1532.0, 473.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.4078077905149, 597.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1369.0, 647.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1316.0, 672.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1378.6383998409233, 675.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1371.0, 717.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.0, 760.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1381.6682908502323, 763.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1374.0, 804.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1237.0, 829.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1383.5823503013635, 844.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1374.0, 424.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.0, 889.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1373.0, 936.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1166.0, 892.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1301.0, 1032.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1379.5833778594779, 1036.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1372.0, 1096.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.9806008066898, 1161.5567861027923

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1292.0, 1163.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1261.599564133703, 1101.5455335748854

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1369.0, 1175.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1374.0, 385.99232831848497

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1159.0, 1192.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.0, 1262.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1203.9527003248377, 1095.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1194.0, 1406.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1224.0, 1453.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1203.0, 1316.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1077.0, 940.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 1003.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.1349158983996, 1001.6184216341884

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.0, 962.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1506.0, 381.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 992.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.7736376535408, 995.8895919219376

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
946.0, 1107.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1012.0, 1129.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1023.8082881023973, 1086.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.0, 1039.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 1072.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.2008586163729, 1008.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1140.0, 215.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1151.1741324081856, 213.8247064873835

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1389.7272287692392, 354.07121595876515

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1110.7431017633523, 207.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1059.1269890331362, 192.36355481996605

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.724699945002, 192.8118762214791

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1029.4625622833173, 185.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.0, 290.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1151.7021550167608, 425.81681957697094

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.4291783057329, 287.7608472263972

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.4228204293095, 195.7694211108734

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.8144945905601, 200.48856596416883

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.3754248529663, 200.99118615599556

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1374.0, 313.1214751973158

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.2987830845308, 193.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.8408590421445, 190.14760745074906

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.3609224517816, 197.99185428944998

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.1159660434203, 190.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1182.0, 1406.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.0, 1465.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.0, 306.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
911.0, 466.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.367306591753, 522.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.0, 296.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1508.6286613210732, 285.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 213.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.9561939940405, 211.95331065619234

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.1518250739341, 205.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 222.09531267333583

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.9656235549245, 221.27236659569408

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.1834263784746, 214.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.1345814735881, 175.13482461779356

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 103.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.346578828079, 169.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.5116931692603, 92.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1349.9416647319606, 282.96434500316667

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 161.15541752799933

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.99009780044383, 154.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.94028500029066, 214.76114000116266

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.631634032896, 207.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.0533836092979, 209.20187988413832

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.880012556292, 203.0823311018662

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 203.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
230.6153172216873, 312.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
230.98619498539998, 345.46977617561174

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 347.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back