1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15886111.csml convertedTime:2009.07.01.10:51

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signaling in B cells via Toll-like receptors.
Authors Peng SL.
Affiliation Departments of Internal Medicine, Washington University School of Medicine, St.Louis, Missouri 63110, USA. speng@im.wustl.edu
Abstract Toll-like receptors (TLRs) and their ligands have emerged as importantregulators of immunity, relevant to a wide range of effector responses fromvaccination to autoimmunity. The most well-studied ligands of TLRs expressed onB cells include the lipopolysaccharides (for TLR4) and CpG-containing DNAs (forTLR9), which induce and/or co-stimulate B cells to undergo proliferation, classswitching and differentiation into antibody-secreting cells. Recent developmentsin this area include advancements into our understanding of the role of thesereceptor pathways in B cells, and in particular the relevance of TLR9, which hasreceived substantial attention as both a Th1-like inflammatory immunomodulatorand a pathogenic co-stimulator of autoreactive B cell responses.
PMID 15886111
Model Abstract

Entity

G010693:Tlr4 G010961:TLR1 G011150:TLR6 G011345:IL10 G013254:TLR8 G013255:TLR9 G013260:TLR7 G013261:TLR10 MO000000022:p38 MO000000203:NIK MO000000212:TRAF6 MO000000213:IRAK-1 MO000000248:IKK MO000000254:p50:RelA-p65:IkappaB-alpha{p} MO000000276:AP-1 MO000007384:IL-6 MO000007694:IRF-3 MO000008179:PKR MO000013119:STAT1 MO000016573:MyD88 MO000016608:IKK-i MO000016632:p50:RelA-p65 {activated} MO000016882:LPS MO000016917:MKK4 MO000016922:CD40 MO000016966:MKK3 MO000017053:IL-4 MO000017247:IL-10 MO000017690:BCR MO000017793:Lp MO000018132:CD14 MO000018217:IgE MO000019005:MKK6 MO000019331:TBK1 MO000019387:cytokines MO000019397:TLR2 MO000019479:protein remnants MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022528:TIRAP MO000038315:LPS:LBP:CD14:TLR4:MD-2:TIRAP:MyD88 MO000038724:p50:RelA-p65:IkappaB-alpha MO000041125:TRIF MO000041132:TRAM MO000041390:JNK1, JNK2 MO000042012:TLR9 MO000042126:TLR7 MO000045685:IgG1 MO000090987:T-bet e1: e10: e11:BCR ligand e12:CD40 ligand e13:CpG DNA e14:RP105: MD-1 e15:TLR4: MD-2 e16:LPS:LBP:CD14: TLR4: MD-2 e17:LPS:LBP:CD14: RP105: MD-1 e18: e19: e2: e20: e21:CpG DNA: anti-DNA IgG autoantibody: TLR9: MyD88 e22:CpG DNA: anti-DNA IgG autoantibody: TLR9: MyD88: IRAK e23:CpG DNA: anti-DNA IgG autoantibody: TLR9: MyD88: IRAK: TRAF6 e24:IRF-3 {nucleus} e25:LPS:LBP:CD14: TLR4: MD-2: TRAM: TRIF e26:IRAK: TRAF6: TAK1: TAB1: TAB2 [activated} e27:IRAK: TRAF6: TAK1: TAB1: TAB2 e28:NIK {activated} e29:IKK {activated} e3: e30:MKK3 [activated} e31:MKK6 {activated} e32:MKK4 {activated} e33:JNK1, JNK2 {activated} e34:p38 [activated} e35:AP-1 {activated} e36:AP-1 {nucleus} e37:p50:RelA-p65 {nucleus} e38:cytokines e39:IKK-i {activated} e4: e40:TBK1 {activated} e41:PKR {activated} e42:STAT1 [activated} e43:IRF-3 {activated} e44:anti-DNA IgG autoantibody e45:CpG DNA: anti-DNA IgG autoantibody e46:CpG DNA: anti-DNA IgG autoantibody: BCR e47:CpG DNA: anti-DNA IgG autoantibody: TLR9 e48:STAT1 [nucleus} e49:immunoglobulin e5:CD40 ligand: CD40 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:BCR ligand: BCR e60: e61: e62: e63:IRAK: TRAF6 e64:TAK1: TAB1: TAB2 e65:Immunoglobulin e66:IgG2a e67:IgG2a e68:IgG2b e69:IgG2b e7: e70:IgG3 e71:IgG3 e72:IgG1 e73:IgE e74:CXCR3 e75:IL-6 e76:porins: TLR2 e77:porins e78:glycoinositolphospholipids e79:Lp: TLR2 e8: e80:glycoinositolphospholipids: TLR2 e81:ssRNA e82:ssRNA: TLR7 e83:IFN-alpha e84:CpG-A ODN e85:CpG-C ODN e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p9
Model Detail
587.0, 959.0
26.0, 26.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p25 p77

--

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
481.0, 1117.0
30.0, 30.0

TLR1

--

G010961

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p1 p2 p3

--

true true true true

csml-variable:Double

m93847

10

false

infinite

0

unit false false false
TRANSFACG010961

--

Go back
523.0, 1143.0
26.0, 26.0

TLR6

--

G011150

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4 p5 p6

--

true true true true

csml-variable:Double

m94035

10

false

infinite

0

unit false false false
TRANSFACG011150

--

Go back
476.0, 1084.0
31.0, 31.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p74

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
571.0, 1215.0
26.0, 26.0

TLR8

--

G013254

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p10 p11 p12

--

true true true true

csml-variable:Double

m95737

10

false

infinite

0

unit false false false
TRANSFACG013254

--

Go back
611.0, 1275.0
26.0, 26.0

TLR9

--

G013255

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p13 p14 p15

--

true true true true

csml-variable:Double

m95738

10

false

infinite

0

unit false false false
TRANSFACG013255

--

Go back
526.0, 1186.0
28.0, 28.0

TLR7

--

G013260

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p7 p8 p9

--

true true true true

csml-variable:Double

m95743

10

false

infinite

0

unit false false false
TRANSFACG013260

--

Go back
690.0, 1274.0
28.0, 28.0

TLR10

--

G013261

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p16 p17 p18

--

true true true true

csml-variable:Double

m95744

10

false

infinite

0

unit false false false
TRANSFACG013261

--

Go back
554.0, 538.0
28.0, 28.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p83

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
916.0, 464.0
32.0, 32.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
682.0, 318.0
28.0, 28.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
682.0, 254.0
28.0, 28.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
853.0, 561.0
30.0, 30.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
971.0, 719.0
34.0, 34.0

p50:RelA-p65:IkappaB-alpha{p}

--

MO000000254

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p47

p34

true true true true

csml-variable:Double

m208

10

false

infinite

0

unit false false false
TRANSPATHMO000000254

--

Go back
500.0, 732.0
32.0, 32.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p84

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
105.0, 1049.0
30.0, 30.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
961.0, 945.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
951.0, 843.0
26.0, 26.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
962.0, 1030.0
28.0, 28.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
749.0, 221.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p55

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
968.0, 392.0
32.0, 32.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
921.0, 793.0
30.0, 30.0

p50:RelA-p65 {activated}

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p41

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
139.0, 939.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26 p27

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
693.0, 641.0
30.0, 30.0

MKK4

--

MO000016917

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m1832

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
419.0, 1447.0
26.0, 26.0

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
693.0, 489.0
30.0, 30.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
140.0, 980.0
26.0, 26.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
137.0, 1085.0
30.0, 30.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
337.0, 1449.0
30.0, 30.0

BCR

--

MO000017690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p52

true true true true

csml-variable:Double

m2450

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
378.0, 46.0
28.0, 28.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
819.0, 131.0
33.0, 33.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
1026.0, 1322.0
28.0, 28.0

IgE

--

MO000018217

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

--

true true true true

csml-variable:Double

m2898

10

false

infinite

0

unit false false false
TRANSPATHMO000018217

--

Go back
695.0, 567.0
26.0, 26.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
974.0, 510.0
28.0, 28.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
722.0, 798.0
30.0, 30.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p85

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
441.0, 173.0
30.0, 30.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76 p78 p79

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
995.0, 775.0
26.0, 26.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
794.0, 70.0
28.0, 28.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
872.0, 172.0
32.0, 32.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p22 p24

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
845.0, 249.0
30.0, 30.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1062.0, 216.0
47.0, 47.0

LPS:LBP:CD14:TLR4:MD-2:TIRAP:MyD88

--

MO000038315

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p30

true true true true

csml-variable:Double

m16530

10

false

infinite

0

unit false false false
TRANSPATHMO000038315

--

Go back
991.0, 663.0
34.0, 34.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p47

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
849.0, 301.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
848.0, 336.0
32.5, 32.5

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
766.0, 734.0
28.0, 28.0

JNK1, JNK2

--

MO000041390

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m19258

10

false

infinite

0

unit false false false
TRANSPATHMO000041390

--

Go back
292.0, 376.0
24.0, 24.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
217.0, 549.0
30.0, 30.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
965.0, 1329.0
30.0, 30.0

IgG1

--

MO000045685

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

--

true true true true

csml-variable:Double

m23310

10

false

infinite

0

unit false false false
InterProIPR003597
TRANSPATHMO000045685

--

Go back
718.0, 1390.0
28.0, 28.0

T-bet

--

MO000090987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62 p63

true true true true

csml-variable:Double

m64461

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000090987

--

Go back
198.69558525798678, 156.96462947943962
921.9144967238935, 1338.6198492430929

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
208.5781672431244, 171.4248140346063
893.6174619574548, 1257.068497532407

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
197.0, 1506.5
30.087873462214418, 19.557117750439375

BCR ligand

--

e11

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p19

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
424.5, 1545.375
31.678383128295245, 20.590949033391915

CD40 ligand

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
125.5, 1408.125
45.0, 15.75

CpG DNA

--

e13

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p1 p4 p7 p10 p13 p16 p51 p64 p65 p66 p67 p68 p69 p70 p71 p72 p73 p74 p75

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
753.625, 150.5
28.919471754707544, 35.41159806698884

RP105: MD-1

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p24

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
934.625, 154.5
34.659681719713376, 42.4404265955674

TLR4: MD-2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p22

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1011.875, 145.5
34.21494769682511, 47.741787483942005

LPS:LBP:CD14: TLR4: MD-2

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p23 p29

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
687.875, 161.5
32.25, 45.0

LPS:LBP:CD14: RP105: MD-1

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
300.0, 270.3552424478032
154.7629757457377, 258.3754764568674

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
300.0, 270.3552424478032
154.7629757457377, 258.3754764568674

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
198.69558525798678, 156.96462947943962
921.9144967238935, 1338.6198492430929

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
300.0, 270.3552424478032
154.7629757457377, 258.3754764568674

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
347.875, 261.5
32.25, 45.0

CpG DNA: anti-DNA IgG autoantibody: TLR9: MyD88

--

e21

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p55 p58

p56

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
419.875, 309.5
32.25, 45.0

CpG DNA: anti-DNA IgG autoantibody: TLR9: MyD88: IRAK

--

e22

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p56

p57

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
439.875, 361.5
32.25, 45.0

CpG DNA: anti-DNA IgG autoantibody: TLR9: MyD88: IRAK: TRAF6

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p58 p62 p63

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
785.0, 1029.0
30.0, 30.0

IRF-3 {nucleus}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1073.875, 291.5
35.28817214167737, 49.23930996513122

LPS:LBP:CD14: TLR4: MD-2: TRAM: TRIF

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p45 p46 p48

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
851.875, 437.5
32.25, 45.0

IRAK: TRAF6: TAK1: TAB1: TAB2 [activated}

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31 p35 p36 p37

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
851.875, 381.5
32.25, 45.0

IRAK: TRAF6: TAK1: TAB1: TAB2

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p30

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
916.0, 512.0
32.0, 32.0

NIK {activated}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p32

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
857.0, 609.0
30.0, 30.0

IKK {activated}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p33

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
217.13387519246464, 175.40291941391754
885.0379168549376, 1301.7432693741378

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
693.0, 529.0
30.0, 30.0

MKK3 [activated}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p39

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
695.0, 603.0
26.0, 26.0

MKK6 {activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p83

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
697.0, 681.0
30.0, 30.0

MKK4 {activated}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p38

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
642.0, 734.0
28.0, 28.0

JNK1, JNK2 {activated}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p84

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000041390

--

Go back
566.0, 590.0
28.0, 28.0

p38 [activated}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39 p83

p40

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
564.0, 788.0
32.0, 32.0

AP-1 {activated}

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40 p84

p42

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
644.0, 880.0
32.0, 32.0

AP-1 {nucleus}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p26 p27 p43 p60

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
781.0, 993.0
30.0, 30.0

p50:RelA-p65 {nucleus}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

p26 p27 p44 p60

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
737.5, 932.0
45.0, 24.0

cytokines

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p43 p44

p85

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
972.0, 444.0
32.0, 32.0

IKK-i {activated}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

p47 p49 p50

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
251.24471157124873, 207.6699267992537
816.8162440973697, 1237.2092546034648

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
978.0, 566.0
28.0, 28.0

TBK1 {activated}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p47 p49 p50

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
950.0, 882.0
28.0, 28.0

PKR {activated}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p47 p49 p50

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
966.0, 1062.0
28.0, 28.0

STAT1 [activated}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p54

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
965.0, 985.0
30.0, 30.0

IRF-3 {activated}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p28

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
552.0, 1534.5
23.53846153846154, 35.30769230769231

anti-DNA IgG autoantibody

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p51

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
645.625, 1525.5
36.75, 45.0

CpG DNA: anti-DNA IgG autoantibody

--

e45

cso30:c:Complex

cso30:i:CC_Extracellular

--

p51

p52 p53

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
707.875, 1432.5
39.62052670214719, 55.28445586346119

CpG DNA: anti-DNA IgG autoantibody: BCR

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p52

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
291.875, 289.5
32.25, 45.0

CpG DNA: anti-DNA IgG autoantibody: TLR9

--

e47

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulumLumen

--

p53

p55

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
770.0, 1062.0
28.0, 28.0

STAT1 [nucleus}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

--

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
576.5, 926.0
38.564013840830455, 20.567474048442907

immunoglobulin

--

e49

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p60

p61

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
482.5, 1436.0
26.43109481753041, 32.36460589901684

CD40 ligand: CD40

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p3 p6 p9 p12 p15 p18 p73 p74 p75

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
371.8432197799491, 867.9450838074598
580.7226095275503, 526.65160305385

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
434.56558728944236, 880.4259611688332
339.5659206548433, 510.4303011117396

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
379.41316068626725, 874.9743146490412
565.5827277149145, 512.5931413706874

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
380.4945808157412, 876.0557347785149
563.4198874559661, 510.4303011117396

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
371.8432197799491, 867.9450838074598
580.7226095275503, 526.65160305385

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
371.8432197799491, 867.9450838074598
580.7226095275503, 526.65160305385

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
380.4945808157412, 876.0557347785149
563.4198874559661, 510.4303011117396

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
795.7599105337662, 1084.2291097022644
36.2803578605375, 32.843271326381384

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
700.5949391400526, 1235.6279278286272
102.73491230003218, 93.00213113476616

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
371.8432197799491, 867.9450838074598
580.7226095275503, 526.65160305385

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
262.5, 1432.0
26.349441759706714, 32.26462256290618

BCR ligand: BCR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p2 p5 p8 p11 p14 p17

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
508.71627134437597, 1101.9847044465705
18.390631761494888, 8.85474862590496

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
508.10215609367606, 1075.5777486664729
62.94681319674263, 113.30426375413687

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
534.5091118737735, 1149.2715787504644
9.82584401119884, 9.82584401119885

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
523.875, 361.5
32.25, 45.0

IRAK: TRAF6

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p59

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
519.875, 473.5
32.25, 45.0

TAK1: TAB1: TAB2

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p59

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
496.5, 800.125
31.720000000000002, 23.789999999999996

Immunoglobulin

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

p61

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
748.0, 1238.0
39.23875432525952, 20.927335640138413

IgG2a

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p62

p63

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
820.5, 1378.0
22.115113704970824, 35.86234654860133

IgG2a

--

e67

cso30:c:Protein

cso30:i:CC_Extracellular

--

p63

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
792.5, 1213.0
39.965397923875436, 21.314878892733564

IgG2b

--

e68

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p64

p65

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
893.125, 1382.5
21.346297041658286, 34.61561682431073

IgG2b

--

e69

cso30:c:Protein

cso30:i:CC_Extracellular

--

p65

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
211.80819705590173, 156.35134157497887
904.1109000502842, 1281.1017919531707

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
777.5, 1164.0
45.0, 24.0

IgG3

--

e70

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66

p67

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
887.125, 1336.5
18.74013886093781, 30.389414369088346

IgG3

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

p67

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
773.5, 1130.0
37.110726643598625, 19.792387543252595

IgG1

--

e72

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p68

p69

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
814.5, 1123.0
34.77508650519031, 18.546712802768166

IgE

--

e73

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p71

p70

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
533.5, 1104.0
45.0, 24.0

CXCR3

--

e74

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p72

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
500.0, 1052.0
24.0, 24.0

IL-6

--

e75

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHG016587

--

Go back
493.625, 169.5
27.449716713881017, 33.611898016997166

porins: TLR2

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p76

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
444.5, 30.375
30.131810193321606, 19.585676625659048

porins

--

e77

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p76

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
298.5, 48.375
34.982425307557115, 22.738576449912127

glycoinositolphospholipids

--

e78

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p79

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
376.625, 165.5
31.00979003499417, 37.97117147142143

Lp: TLR2

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p78

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
215.038226868679, 178.96155026442
867.324359596112, 1259.3549701335553

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
306.625, 167.5
26.829153474420924, 32.85202466255624

glycoinositolphospholipids: TLR2

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p79

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
124.5, 552.625
39.6257197696737, 21.794145873320538

ssRNA

--

e81

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p80

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
215.625, 612.5
32.21825529078486, 39.45092484585902

ssRNA: TLR7

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p80

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
517.0, 1013.0
29.0, 29.0

IFN-alpha

--

e83

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p81 p82

--

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
33.5, 1008.125
45.0, 15.75

CpG-A ODN

--

e84

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p81

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
33.5, 1032.125
45.0, 15.75

CpG-C ODN

--

e85

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p82

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
223.65163970275185, 201.57175895386118
863.3645481373144, 1242.8388452660563

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
417.0, 1129.0
21.0, 21.0

p1

p1

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G010961

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c1 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
512.0, 1288.0
23.0, 23.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G013254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c10 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
521.0, 1317.0
21.0, 21.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G013254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c11 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
561.0, 1309.0
21.0, 21.0

p12

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G013254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c12 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
582.0, 1334.0
19.0, 19.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G013255

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c13 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
610.0, 1342.0
19.0, 19.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G013255

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c14 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo. PMID: 15886111, 12689944 , 12560217 B cells are now particularly well recognized for their expression of the TLR9 and TLR10, which are induced in response to BCR stimulation and appear to predominate in activated and/or memory populations.

Go back
637.0, 1341.0
21.0, 21.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G013255

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c15 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
673.0, 1341.0
21.0, 21.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G013261

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c16 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
706.0, 1346.0
19.0, 19.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G013261

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c17 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo. PMID: 15886111, 12689944 , 12560217 B cells are now particularly well recognized for their expression of the TLR9 and TLR10, which are induced in response to BCR stimulation and appear to predominate in activated and/or memory populations.

Go back
733.0, 1333.0
21.0, 21.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G013261

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c18 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
264.0, 1504.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 MO000017690

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m11*m2450*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
395.0, 1163.0
17.0, 17.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G010961

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c2 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
484.0, 1540.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016922 e12

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m1837*m12*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
875.0, 71.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 15886111 Extracellular lipopolysaccharide (LPS) is bound by LPS-binding protein (LBP), recognized by CD14, and brought in proximity to the TLR4?MD-2 and RP105?MD-1 heterodimers.

Go back
937.0, 77.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021929 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m6255*m15*0.1

nodelay

--

true

0

false

PMID: 15886111 Extracellular lipopolysaccharide (LPS) is bound by LPS-binding protein (LBP), recognized by CD14, and brought in proximity to the TLR4?MD-2 and RP105?MD-1 heterodimers.

Go back
1016.0, 224.0
23.0, 23.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000016573 MO000022528

MO000038315

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c62 : 1

m16*m1572*m6810*0.1

nodelay

--

true

0

false

PMID: 15886111 TLR4 initiates signaling via at least two adaptor pathways: TIRAP?MyD88 and TRIF?TRAM.

Go back
755.0, 99.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021929 e14

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m6255*m14*0.1

nodelay

--

true

0

false

PMID: 15886111 Extracellular lipopolysaccharide (LPS) is bound by LPS-binding protein (LBP), recognized by CD14, and brought in proximity to the TLR4?MD-2 and RP105?MD-1 heterodimers.

Go back
472.0, 960.0
23.0, 23.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 15886111, 14707068 This spectrum of inducible expression of the TLRs has been generally presumed to extend to rodent B cells; however, species differences clearly exist, as na?ve murine B cells are known to express TLR4 and undergo proliferation and plasmacytoid differentiation in vitro in response to LPS exposure, in contrast to human B cells, which seem to lack significant TLR4 expression, at least in the na?ve resting state.

Go back
142.0, 858.0
27.0, 27.0

p26

p26

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000016882 e37 e36

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m155666*m38*m37*0.1

nodelay

--

true

0

false

PMID: 15886111, 14707068 This spectrum of inducible expression of the TLRs has been generally presumed to extend to rodent B cells; however, species differences clearly exist, as na?ve murine B cells are known to express TLR4 and undergo proliferation and plasmacytoid differentiation in vitro in response to LPS exposure, in contrast to human B cells, which seem to lack significant TLR4 expression, at least in the na?ve resting state. PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in B cell activation, proliferation, and immunoglobulin (Ig) production.

Go back
110.0, 814.0
27.0, 27.0

p27

p27

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

MO000016882 e37 e36

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m155666*m38*m37*0.1

nodelay

--

true

0

false

PMID: 15886111, 14707068 This spectrum of inducible expression of the TLRs has been generally presumed to extend to rodent B cells; however, species differences clearly exist, as na?ve murine B cells are known to express TLR4 and undergo proliferation and plasmacytoid differentiation in vitro in response to LPS exposure, in contrast to human B cells, which seem to lack significant TLR4 expression, at least in the na?ve resting state. PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in B cell activation, proliferation, and immunoglobulin (Ig) production.

Go back
836.0, 988.0
23.0, 23.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e43

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 15886111 Together, these kinases result in both IkappaB phosphorylation and NF-kappaB activation, enhancing the transcription of inflammatory cytokines, as well as the activation of STAT1 and IRF-3, which regulate the expression of IFN-inducible genes.

Go back
971.0, 303.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041132 e16

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m18998*m19005*m16*0.1

nodelay

--

true

0

false

PMID: 15886111 TLR4 initiates signaling via at least two adaptor pathways: TIRAP?MyD88 and TRIF?TRAM.

Go back
421.0, 1169.0
21.0, 21.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G010961

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c3 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
921.0, 389.0
30.0, 30.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 MO000038315

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1

m27*m16530*0.1

nodelay

--

true

0

false

PMID: 15886111 The TIRAP?MyD88 pathway elicits an IRAK?TRAF6?TAK1 pathway. PMID: 15886111 TAK1 activates NIK, which activates the IKK complex, which in turn phosphorylates the IkappaB proteins that normally sequester NF-kappaB proteins in the cytoplasm.

Go back
855.0, 515.0
25.0, 25.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000203 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m174*m26*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 activates NIK, which activates the IKK complex, which in turn phosphorylates the IkappaB proteins that normally sequester NF-kappaB proteins in the cytoplasm.

Go back
920.0, 564.0
23.0, 23.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m207*m28*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 activates NIK, which activates the IKK complex, which in turn phosphorylates the IkappaB proteins that normally sequester NF-kappaB proteins in the cytoplasm.

Go back
924.0, 668.0
23.0, 23.0

p33

p33

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e29

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m16910*m29*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 activates NIK, which activates the IKK complex, which in turn phosphorylates the IkappaB proteins that normally sequester NF-kappaB proteins in the cytoplasm.

Go back
923.0, 723.0
25.0, 25.0

p34

p34

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

MO000000254

MO000019479 MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m208*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 activates NIK, which activates the IKK complex, which in turn phosphorylates the IkappaB proteins that normally sequester NF-kappaB proteins in the cytoplasm. PMID: 15886111 Together, these kinases result in both IkappaB phosphorylation and NF-kappaB activation, enhancing the transcription of inflammatory cytokines, as well as the activation of STAT1 and IRF-3, which regulate the expression of IFN-inducible genes.

Go back
760.0, 492.0
23.0, 23.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016966 e26

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c86 : 1
stoichiometry:c83 : 1

m1875*m26*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
755.0, 567.0
25.0, 25.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019005 e26

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c87 : 1
stoichiometry:c85 : 1

m3613*m26*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
754.0, 642.0
27.0, 27.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 MO000016917

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m26*m1832*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
699.0, 735.0
25.0, 25.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041390 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c97 : 1
stoichiometry:c94 : 1

m19258*m32*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
611.0, 539.0
25.0, 25.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e30

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c95 : 1
stoichiometry:c92 : 1

m34*m30*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
406.0, 1198.0
19.0, 19.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G011150

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c4 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
568.0, 736.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000000276

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m35*m219*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
845.0, 793.0
30.0, 30.0

p41

p41

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016632

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in inflammation, particularly cytokines. PMID: 15886111 Together, these kinases result in both IkappaB phosphorylation and NF-kappaB activation, enhancing the transcription of inflammatory cytokines, as well as the activation of STAT1 and IRF-3, which regulate the expression of IFN-inducible genes.

Go back
641.0, 789.0
29.0, 29.0

p42

p42

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in inflammation, particularly cytokines.

Go back
708.0, 892.0
23.0, 23.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c106 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in inflammation, particularly cytokines.

Go back
775.0, 915.0
25.0, 25.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c107 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in inflammation, particularly cytokines.

Go back
1024.0, 396.0
23.0, 23.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e25

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c114 : 1
stoichiometry:c111 : 1

m1599*m25*0.1

nodelay

--

true

0

false

PMID: 15886111, 14745443 The TRIF?TRAM pathway results in activation of the atypical IKKs IKK-epsilon and TBK1, as well as the IFN-inducible PKR.

Go back
1023.0, 511.0
25.0, 25.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e25

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c115 : 1
stoichiometry:c113 : 1

m3902*m25*0.1

nodelay

--

true

0

false

PMID: 15886111, 14745443 The TRIF?TRAM pathway results in activation of the atypical IKKs IKK-epsilon and TBK1, as well as the IFN-inducible PKR.

Go back
927.0, 623.0
25.0, 25.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39 e40 MO000038724 e41

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c59 : 1
stoichiometry:c119 : 1

m40*m41*m16910*m42*0.1

nodelay

--

true

0

false

PMID: 15886111 Together, these kinases result in both IkappaB phosphorylation and NF-kappaB activation, enhancing the transcription of inflammatory cytokines, as well as the activation of STAT1 and IRF-3, which regulate the expression of IFN-inducible genes.

Go back
1005.0, 845.0
25.0, 25.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000008179 e25

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m1055*m25*0.1

nodelay

--

true

0

false

PMID: 15886111, 14745443 The TRIF?TRAM pathway results in activation of the atypical IKKs IKK-epsilon and TBK1, as well as the IFN-inducible PKR.

Go back
1014.0, 1030.0
27.0, 27.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013119 e41 e39 e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c61 : 1
stoichiometry:c137 : 1
stoichiometry:c142 : 1
stoichiometry:c126 : 1

m1357*m42*m40*m41*0.1

nodelay

--

true

0

false

PMID: 15886111 Together, these kinases result in both IkappaB phosphorylation and NF-kappaB activation, enhancing the transcription of inflammatory cytokines, as well as the activation of STAT1 and IRF-3, which regulate the expression of IFN-inducible genes.

Go back
421.0, 1225.0
21.0, 21.0

p5

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G011150

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c5 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
1015.0, 947.0
25.0, 25.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e41 e39 e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c60 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c124 : 1

m977*m42*m40*m41*0.1

nodelay

--

true

0

false

PMID: 15886111 Together, these kinases result in both IkappaB phosphorylation and NF-kappaB activation, enhancing the transcription of inflammatory cytokines, as well as the activation of STAT1 and IRF-3, which regulate the expression of IFN-inducible genes.

Go back
601.0, 1541.0
21.0, 21.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c230 : 1

m13*m45*0.1

nodelay

--

true

0

false

PMID: 15886111, 11948342 For instance, anti-DNA IgG autoantibodies can form complexes with hypomethylated CpG-containing DNAs, and then bind both to rheumatoid factor (anti-IgG) B cells through their BCR via direct IgG binding, and to TLR9 via binding of the co-complexed DNA, resulting in activation.

Go back
712.0, 1536.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45 MO000017690

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m46*m2450*0.1

nodelay

--

true

0

false

PMID: 15886111, 11948342 For instance, anti-DNA IgG autoantibodies can form complexes with hypomethylated CpG-containing DNAs, and then bind both to rheumatoid factor (anti-IgG) B cells through their BCR via direct IgG binding, and to TLR9 via binding of the co-complexed DNA, resulting in activation. PMID: 15886111 Environmental CpG-containing DNAs (mammalian or non-mammalian) are directly endocytosed or internalized after binding to anti-DNA BCRs.

Go back
88.0, 376.0
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e45

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m19828*m46*0.1

nodelay

--

true

0

false

PMID: 15886111, 11948342 For instance, anti-DNA IgG autoantibodies can form complexes with hypomethylated CpG-containing DNAs, and then bind both to rheumatoid factor (anti-IgG) B cells through their BCR via direct IgG binding, and to TLR9 via binding of the co-complexed DNA, resulting in activation.

Go back
868.0, 1064.0
23.0, 23.0

p54

p54

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e42

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 15886111 Together, these kinases result in both IkappaB phosphorylation and NF-kappaB activation, enhancing the transcription of inflammatory cytokines, as well as the activation of STAT1 and IRF-3, which regulate the expression of IFN-inducible genes.

Go back
299.0, 223.0
25.0, 25.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e47

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m1572*m48*0.1

nodelay

--

true

0

false

PMID: 15886111 TLR9, normally generated and found in the endoplasmic reticulum, encounters CpG DNAs in lysosomal/late endosomal compartments, where it initiates a signaling cascade via MyD88?IRAK?TRAF6?TAK1, similar to TLR4 (Figure 1 but without TIRAP.

Go back
455.0, 255.0
25.0, 25.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c148 : 1
stoichiometry:c147 : 1

m184*m21*0.1

nodelay

--

true

0

false

PMID: 15886111 TLR9, normally generated and found in the endoplasmic reticulum, encounters CpG DNAs in lysosomal/late endosomal compartments, where it initiates a signaling cascade via MyD88?IRAK?TRAF6?TAK1, similar to TLR4 (Figure 1 but without TIRAP.

Go back
488.0, 320.0
23.0, 23.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m183*m22*0.1

nodelay

--

true

0

false

PMID: 15886111 TLR9, normally generated and found in the endoplasmic reticulum, encounters CpG DNAs in lysosomal/late endosomal compartments, where it initiates a signaling cascade via MyD88?IRAK?TRAF6?TAK1, similar to TLR4 (Figure 1 but without TIRAP.

Go back
471.0, 435.0
25.0, 25.0

p58

p58

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e23

e63 e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c154 : 1
stoichiometry:c153 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 15886111 TLR9, normally generated and found in the endoplasmic reticulum, encounters CpG DNAs in lysosomal/late endosomal compartments, where it initiates a signaling cascade via MyD88?IRAK?TRAF6?TAK1, similar to TLR4 (Figure 1 but without TIRAP.

Go back
611.0, 391.0
26.0, 26.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 e64

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m64*m65*0.1

nodelay

--

true

0

false

PMID: 15886111 TLR9, normally generated and found in the endoplasmic reticulum, encounters CpG DNAs in lysosomal/late endosomal compartments, where it initiates a signaling cascade via MyD88?IRAK?TRAF6?TAK1, similar to TLR4 (Figure 1 but without TIRAP.

Go back
455.0, 1215.0
17.0, 17.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G011150

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c6 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
648.0, 944.0
23.0, 23.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36 e37

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c165 : 1

m37*m38*0.1

nodelay

--

true

0

false

PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in B cell activation, proliferation, and immunoglobulin (Ig) production.

Go back
534.0, 838.0
27.0, 27.0

p61

p61

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e49

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c166 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 15886111 Both the NF-kappaB and AP-1 proteins enter the nucleus where they activate target genes involved in B cell activation, proliferation, and immunoglobulin (Ig) production.

Go back
756.0, 1300.0
23.0, 23.0

p62

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23 MO000090987

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c192 : 1
stoichiometry:c167 : 1

m23*m64461*0.1

nodelay

--

true

0

false

PMID: 15886111 In such studies, CpG treatments are associated with the preferential production of ¡ÆTh1-like¡Ç immunoglobulin isotypes, such as the IFN-gamma-related IgG2a in mice. PMID: 15886111, 15114682, 14586416 Interestingly, the Th1-like effect requires the classical MyD88 adaptor pathway and, at least for IgG2a class switching, requires the Th1-related T-box transcription factor T-bet, but the effect of CpG DNAs on IgG1 and IgE production appears to be at least partially MyD88 independent.

Go back
778.0, 1382.0
27.0, 27.0

p63

p63

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e23 MO000090987

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c171 : 1
stoichiometry:c193 : 1
stoichiometry:c168 : 1

m67*m23*m64461*0.1

nodelay

--

true

0

false

PMID: 15886111 In such studies, CpG treatments are associated with the preferential production of ¡ÆTh1-like¡Ç immunoglobulin isotypes, such as the IFN-gamma-related IgG2a in mice. PMID: 15886111, 15114682, 14586416 Interestingly, the Th1-like effect requires the classical MyD88 adaptor pathway and, at least for IgG2a class switching, requires the Th1-related T-box transcription factor T-bet, but the effect of CpG DNAs on IgG1 and IgE production appears to be at least partially MyD88 independent.

Go back
801.0, 1285.0
21.0, 21.0

p64

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c172 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
843.0, 1347.0
25.0, 25.0

p65

p65

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e68 e13

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c176 : 1
stoichiometry:c173 : 1

m69*m13*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
856.0, 1264.0
23.0, 23.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c177 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
907.0, 1283.0
25.0, 25.0

p67

p67

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e70 e13

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c181 : 1
stoichiometry:c178 : 1

m71*m13*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
871.0, 1219.0
25.0, 25.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c182 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
939.0, 1259.0
25.0, 25.0

p69

p69

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e72 e13

MO000045685

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c189 : 1
stoichiometry:c183 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
434.0, 1250.0
19.0, 19.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G013260

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c7 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
990.0, 1270.0
27.0, 27.0

p70

p70

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e73 e13

MO000018217

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c191 : 1
stoichiometry:c186 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
901.0, 1161.0
21.0, 21.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c185 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15886111, 15114682, 12766768, 14586416 Previously, such effects upon B cells were presumed to reflect the indirect effect of skewing towards and/or preferential survival of Th1 cells in the helper T cell compartment, but recent studies indicate that CpG DNAs might have direct effects upon murine B cells, inducing and/or promoting class switching to ¡ÆTh1-like¡Ç isotypes, such as IgG2a, IgG2b and IgG3, while suppressing the production of the ¡ÆTh2-like¡Ç (IL-4-related) isotypes IgG1 and IgE.

Go back
391.0, 1103.0
25.0, 25.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c194 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 15886111, 12778475, 15249208, 15070685 Other studies have indicated that, whereas CpG DNAs alone can induce the expression of co-stimulatory molecules and chemokine receptors such as CXCR3 in human B cells, CpG DNAs require synergistic cooperation with CD40 signals and/or simultaneous culture with plasmacytoid dendritic cells to induce secretion of immunoglobulins or cytokines such as IL-6 and IL-10, or to promote Th1 development by helper T cells

Go back
295.0, 1051.0
25.0, 25.0

p73

p73

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e75 e13 e5

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c199 : 1
stoichiometry:c203 : 1
stoichiometry:c196 : 1

m76*m13*m5*0.1

nodelay

--

true

0

false

PMID: 15886111, 12778475, 15249208, 15070685 Other studies have indicated that, whereas CpG DNAs alone can induce the expression of co-stimulatory molecules and chemokine receptors such as CXCR3 in human B cells, CpG DNAs require synergistic cooperation with CD40 signals and/or simultaneous culture with plasmacytoid dendritic cells to induce secretion of immunoglobulins or cytokines such as IL-6 and IL-10, or to promote Th1 development by helper T cells

Go back
296.0, 1088.0
23.0, 23.0

p74

p74

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e13 G011345 e5

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c198 : 1

m13*m94230*m5*0.1

nodelay

--

true

0

false

PMID: 15886111, 12778475, 15249208, 15070685 Other studies have indicated that, whereas CpG DNAs alone can induce the expression of co-stimulatory molecules and chemokine receptors such as CXCR3 in human B cells, CpG DNAs require synergistic cooperation with CD40 signals and/or simultaneous culture with plasmacytoid dendritic cells to induce secretion of immunoglobulins or cytokines such as IL-6 and IL-10, or to promote Th1 development by helper T cells

Go back
43.0, 1463.0
25.0, 25.0

p75

p75

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e13 e5

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m13*m5*0.1

nodelay

--

true

0

false

PMID: 15886111, 14707068 Other studies have indicated that, whereas CpG DNAs alone can induce the expression of co-stimulatory molecules and chemokine receptors such as CXCR3 in human B cells, CpG DNAs require synergistic cooperation with CD40 signals and/or simultaneous culture with plasmacytoid dendritic cells to induce secretion of immunoglobulins or cytokines such as IL-6 and IL-10, or to promote Th1 development by helper T cells

Go back
445.0, 113.0
27.0, 27.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e77 MO000019397

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m78*m3964*0.1

nodelay

--

true

0

false

PMID: 15886111, 11823477 Other TLRs similarly seem likely to affect B cell function both in humans and rodents in vivo. TLR2 ligands, such as neisserial porins, lipoproteins and glycoinositolphospholipids, have been shown to activate B cells, generally acting as mitogens.

Go back
448.0, 984.0
23.0, 23.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000017053

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c206 : 1

m1947*0.1

nodelay

--

true

0

false

PMID: 15886111, 11841848 Furthermore, some studies have indicated that TLR4 expression can in fact be induced in human B cells by specific stimuli, such as IL-4.

Go back
380.0, 108.0
23.0, 23.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000017793

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c216 : 1

m3964*m2549*0.1

nodelay

--

true

0

false

PMID: 15886111, 11823477 Other TLRs similarly seem likely to affect B cell function both in humans and rodents in vivo. TLR2 ligands, such as neisserial porins, lipoproteins and glycoinositolphospholipids, have been shown to activate B cells, generally acting as mitogens.

Go back
305.0, 109.0
25.0, 25.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e78 MO000019397

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c213 : 1
stoichiometry:c212 : 1

m79*m3964*0.1

nodelay

--

true

0

false

PMID: 15886111, 11823477 Other TLRs similarly seem likely to affect B cell function both in humans and rodents in vivo. TLR2 ligands, such as neisserial porins, lipoproteins and glycoinositolphospholipids, have been shown to activate B cells, generally acting as mitogens.

Go back
466.0, 1258.0
19.0, 19.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G013260

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c9 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
132.0, 620.0
23.0, 23.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m19940*m82*0.1

nodelay

--

true

0

false

PMID: 15886111, 14976261, 14976262, 15034168 Also, the TLR7-binding guanosine analogs can stimulate human B cells, suggesting that B cells can be stimulated by the physiological ligands of TLR7, the single-stranded RNAs.

Go back
424.0, 1008.0
23.0, 23.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e84

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c222 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 15886111, 14971051, 15481148 For instance, species-specific differences in optimal CpG sequences suggest differential regulation and/or recognition of TLR9 binding and/or signaling, and it has become clear that several ¡Æclasses¡Ç of stimulatory CpG oligonucleotides (ODNs) exist: CpG-A ODNs, which strongly induce IFN-¦Á in plasmacytoid dendritic cells (PDCs) and potently activate NK cells; CpG-B ODNs, which potently activate NK and B cells but not PDCs; and CpG-C ODNs, which combine the effects of both.

Go back
425.0, 1037.0
21.0, 21.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e85

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c223 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 15886111, 14971051, 15481148 For instance, species-specific differences in optimal CpG sequences suggest differential regulation and/or recognition of TLR9 binding and/or signaling, and it has become clear that several ¡Æclasses¡Ç of stimulatory CpG oligonucleotides (ODNs) exist: CpG-A ODNs, which strongly induce IFN-¦Á in plasmacytoid dendritic cells (PDCs) and potently activate NK cells; CpG-B ODNs, which potently activate NK and B cells but not PDCs; and CpG-C ODNs, which combine the effects of both.

Go back
615.0, 599.0
25.0, 25.0

p39

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 MO000000022

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m31*m34*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
616.0, 684.0
23.0, 23.0

p40

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c228 : 1
stoichiometry:c227 : 1

m219*m33*0.1

nodelay

--

true

0

false

PMID: 15886111 TAK1 also activates the JNK and p38 MAPK pathways, leading to the activation of AP-1 complexes.

Go back
766.0, 842.0
27.0, 27.0

p61

p85

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e38

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c229 : 1

m39*0.1

nodelay

--

true

0

false

--

Go back
493.0, 1265.0
21.0, 21.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G013260

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c8 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15886111 Although most studies agree that mRNAs corresponding to all TLRs can be detected in B cells, significant expression is only generally agreed upon at this time for TLR1 and TLR6?10, all of which are upregulated during activation; for example, in response to B cell receptor (BCR) or CD40 ligation, CpG oligonucleotide exposure in vitro, and as seen in activated B cell subsets ex vivo.

Go back
438.0, 1134.9240068653964

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 1247.1564935530407

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 748.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 759.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.0, 808.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.421926492615, 823.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.0, 804.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 818.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 915.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.8599434057004, 935.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.0, 898.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.7513807567653, 947.9646360217126

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.0, 1248.1175644130494

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.0, 408.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.416452246567, 419.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.0, 524.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.9975603804354, 536.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.2065767803003, 341.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1041.0895603782028, 341.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
946.1004955415568, 476.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
957.4513482233507, 594.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
958.735033111711, 648.3173289177635

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.0, 648.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 1248.9308381279197

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 857.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.5424513544061, 867.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1021.0851161840194, 341.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
991.0, 960.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0955145420756, 971.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
990.0, 1044.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.5538553641524, 1053.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.0, 1424.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 1552.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 1548.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.0, 1307.9329796549935

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.55723941336265, 1479.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.0, 1495.9930645847387

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
119.0, 388.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.76416550503166, 406.9999998546309

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
111.0, 320.7406115841077

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1004.0, 459.75647756093076

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 579.7592129661979

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1004.0, 444.0093766667169

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
867.0, 1000.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.9322862329901, 1011.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.0, 1308.990498808999

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.0, 1076.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 1076.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.0, 556.0060535425797

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.0, 236.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.0, 255.9909451017955

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 247.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 268.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.5777087639997, 280.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.0, 271.2639240088534

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 332.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.8089875327071, 1308.4906334205523

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 332.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.22895896276873, 343.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.0, 407.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.71133186657244, 312.46555117859407

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.0, 408.00931918759903

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 388.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 422.7488171341327

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.0, 404.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
176.82540077132077, 876.6622583337773

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
176.99143317098557, 873.3701295363404

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
687.0, 1309.5894663844042

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
144.72608320337824, 833.0754850841373

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
144.93701294814676, 831.0019109046971

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.0, 912.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.4737470894349, 962.853612525057

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.9813556589606, 871.9389341484742

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.6561952354677, 944.320059162263

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.2063309876478, 830.0740528189224

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.0, 1267.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.0, 1396.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.0, 1259.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
707.4310835055999, 1309.8709592807993

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 407.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.7385933824321, 407.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
812.0, 1242.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.0, 1370.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
815.0, 1234.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.0, 1313.99999904189

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.0, 1379.9999999921663

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
812.5174713247359, 1194.6024580899987

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.0588143418104, 1308.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 1188.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.629976047529, 1308.5240571578818

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
149.0, 1294.9985378258853

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
128.02102680443926, 1315.9995988653857

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
807.6568542494924, 1155.6568542494924

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.0, 1284.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.0, 1150.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.1554175279994, 1144.5777087639997

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.0, 1297.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 1142.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
88.04210091627567, 1231.9843820407075

c188

c188

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
116.0400253608359, 1287.999852872312

c189

c189

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
227.0, 1516.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
59.810393850808055, 1171.962453926596

c190

c190

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
103.56792415218138, 1300.9999999986808

c191

c191

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
738.0, 1330.4581244641497

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.0, 1398.9922778767136

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
416.0, 1116.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
155.0, 1134.0847777432757

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.0, 1064.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 1064.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 1100.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
152.0, 1083.2821804582848

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
412.0, 1141.1898088913156

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.6154120165562, 1474.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
152.0, 1118.1409332306273

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
327.0, 1100.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.7590657441572, 1118.061828710122

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.48134928432216, 1083.2027916227355

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
74.71656125721721, 1424.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
75.98878252860993, 1453.0

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
471.0, 975.3592553320611

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
166.0, 993.0

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
459.1269681330138, 50.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
457.0, 147.99632943316306

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 1472.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.0, 140.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 71.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.0, 134.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.21927360848974, 131.44704055180142

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.51724137931035, 136.79310344827587

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 74.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 131.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
161.3257896609113, 575.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
144.0, 574.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 632.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.0, 1473.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
79.0, 1016.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
79.0, 1040.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.0, 1021.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.0, 1032.6536394278642

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.9947159835715, 613.2907169448572

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.0, 566.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.8587085313798, 607.49689686312

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.2491077284276, 707.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.68253731564, 714.1020362515915

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
757.6568542494924, 833.6568542494924

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.0, 1553.5699763999032

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.0, 1549.66436383883

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 1476.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.0, 1155.613173918257

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 1220.8973855439313

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
163.0, 1268.7335017130042

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
171.0, 1306.3542623088358

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
171.0, 1347.2684211133171

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
442.0, 1147.7736221307564

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
171.0, 1353.949417897649

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
283.0, 1187.2560717419874

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
288.0, 1252.4413170219332

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.0, 1282.3461425405233

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.0, 1336.4018665673195

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.0, 1357.1374347001874

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.0, 1359.6338838486593

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
435.8358429531904, 1197.7865063187041

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
466.1259350349792, 1239.920370590888

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.0, 1293.9913030912646

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
425.0, 1165.1513543886333

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.0, 1336.9338366382672

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.0, 1363.3892515318946

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.0, 1352.1790199212408

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.0, 84.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.0, 102.24695047554424

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 96.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.0, 108.77309239368803

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.1509165355809, 109.99857638578818

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.0, 102.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.0, 193.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.0, 1170.8625114189456

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.0, 236.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 239.287942043912

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.7674048207653, 124.26640738700416

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 132.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.288244344552, 124.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
165.0, 953.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.0, 972.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
153.0, 892.9945186701341

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
128.75230673845377, 848.8057300167486

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.9999999652329, 635.9824379129661

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
472.0, 1173.48291759204

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.0, 910.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
970.0, 910.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1039.0, 237.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0, 316.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 322.2987830845308

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.3624501667941, 193.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 316.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.0, 404.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.1321638494413, 416.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.3930428490266, 263.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
453.0, 1213.1979831203844

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.4, 492.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.0, 528.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.0, 483.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
883.0, 576.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.2839333778203, 586.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0, 544.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
955.0, 680.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.0, 691.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.0, 637.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
948.0, 745.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.0, 1221.238549617608

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.0, 748.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
956.0, 736.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 504.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.7942826023124, 511.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.0, 580.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.8954737212622, 588.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
790.2575058752865, 467.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
784.1076980641999, 479.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
778.6668650204595, 483.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
723.0, 656.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.0, 1219.7868443531486

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.5424513544061, 666.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.0, 552.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.1675379317294, 564.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.0, 748.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.0, 748.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.9560436233712, 545.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 705.3688904516371

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.0, 711.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 618.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.0, 876.8094964814716

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back