1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15950447.csml convertedTime:2009.07.01.10:51

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Pathogen recognition with Toll-like receptors.
Authors Kawai T, Akira S.
Affiliation Exploratory Research for Advanced Technology (ERATO), Japan Science andTechnology Agency, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract The innate immune system is an evolutionarily conserved system of defenseagainst microbial infections. The family of Toll-like receptors is a major classof receptors that sense molecular patterns associated with a broad range ofpathogens including bacteria, viruses, fungi and protozoa. Following pathogenrecognition, Toll-like receptors initiate intracellular signal transduction thatresults in the expression of genes involved in inflammation, antiviral responsesand maturation of dendritic cells. Individual Toll-like receptors activatecommon and unique transcription factors through different signaling pathways todrive specific biological responses against microorganisms.
PMID 15950447
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010389:IL-1beta G010431:ICAM-1 G011345:IL10 G016992:IFN-alpha MO000000011:ERK MO000000058:NF-kappaB MO000000065:RIP1 MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK-1 MO000000276:AP-1 MO000007185:IRF-8 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016608:IKK-i MO000016658:IFN Type I MO000016659:IFNalpha MO000016661:IKK-alpha:IKK-beta:IKK-gamma MO000016882:LPS MO000016899:FADD MO000017793:Lp MO000019331:TBK1 MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019479:protein remnants MO000020434:Nod1 MO000020461:Nod2 MO000022185:flagellin MO000022224:dsRNA MO000038306:ERK{p} MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042006:TLR8(h) MO000042007:TLR8 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 MO000042130:TLR11 MO000068831:MAL e1: e10: e100:IRF-5{activated} e101:IRF-5{nucleus} e102:IRF-5: proinflammatory cytokines e103:proinflammatory cytokines e104:proinflammatory cytokines e105:IRF-8{activated} e106:IL-12p70 e107:IFN Type I e108:RIG-1 e109:dsRNA: RIG-1 e11:TLR2: TLR1 e110:PGN: Nod1 e111:PGN: NOD2 e112:protein remnants: NOD1 e113:protein remnants: NOD2 e12:tri-acyi lipopeptide e13:Di-acyl lipopeptide e14:Di-acyl lipopeptide: TLR2: TLR6 e15:tri-acyi lipopeptide: TLR2: TLR1 e16:PAMPs e17:PAMP: TLR e18:flagellin: TLR5 e19:uropathogenic bacterial ligand: TLR11 e2: e20:uropathogenic bacterial ligand e21:CpG DNA e22:CpG DNA: TLR9 e23:homozoin: TLR9 e24:homozoin e25:viral ssRNA e26:viral ssRNA: TLR8 e27:viral ssRNA: TLR7 e28:PGN: TLR2 e29:lipopeptides e3: e30:lipopeptides: TLR2 e31:Lp: TLR2 e32:dectin-1 e33:zymosan e34:zymosan: TLR2: dectin-1 e35:TLR ligands e36:TLR2 ligands: CD36 e37:CD36 e38:target genes e39:resiquimod e4: e40:resiquimod: TLR8{h} e41:resiquimod: TLR7 e42:imiquimod e43:imiquimod: TLR8{h} e44:imiquimod: TLR7 e45:loxoribine e46:loxoribine: TLR8{h} e47:loxoribine: TLR8{h} e48:West Nile Viru sligand: TLR3 e49:West Nile Viru sligand e5:LPS: TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR2: TLR6 e60: e61: e62: e63:PAMPs: TLR: MyD88 e64:PAMPs: TLR: MyD88 : IRAK-1: IRAK-4 e65:PAMPs: TLR: MyD88 : IRAK-1: IRAK-4{p} e66:LPS: TLR4: MAL e67:PAMPs: TLR: MyD88 : IRAK-1{p}: IRAK-4{p} e68:IRAK-1{p}: IRAK-4{p} e69:IRAK-1{p}: IRAK-4{p}: TRAF6 e7: e70:IRAK-1{p}: IRAK-4{p}: TRAF6: TAK1 e71:MAPKs{activated} e72:IKK-alpha:IKK-beta:IKK-gamma{activated} e73:NF-kappaB{activated} e74:AP-1{activated} e75:NF-kappaB{nucleus} e76:LPS: TLR4: MAL: MyD88 e77:Lp: TLR2: MAL e78:Lp: TLR2: MAL: MyD88 e79:LPS: TLR4: TRAM e8: e80:LPS: TLR4: TRAM: TRIF e81:dsRNA: TLR3: TRIF e82:TBK1{activated} e83:IKK-i{activated} e84:IRF-3{p}{nucleus} e85:IFN inducible gene e86:LPS: TLR4: TRAM: TRIF e87:dsRNA: TLR3: TRIF: RIP1 e88:dsRNA: TLR3: TRIF: RIP1: TRAF6 e89:viral ssRNA: TLR7: MyD88 e9: e90:CpG DNA: TLR9: MyD88 e91:viral ssRNA: TLR7: MyD88: IRAK-1{p}: IRAK-4{p} e92:viral ssRNA: TLR7: MyD88: IRAK-1{p}: IRAK-4{p}: TRAF6 e93:CpG DNA: TLR9: MyD88: IRAK-1{p}: IRAK-4{p} e94:CpG DNA: TLR9: MyD88: IRAK-1{p}: IRAK-4{p}: TRAF6 e95:viral ssRNA: TLR7: MyD88: IRAK-1{p}: IRAK-4{p}: TRAF6: IRF-7 e96:CpG DNA: TLR9: MyD88: IRAK-1{p}: IRAK-4{p}: IRF-7 e97:IRF-7{p}{nucleus} e98:PAMPs: TLR: MyD88 : IRAK-1{p}: IRAK-4{p}: TRAF6 e99:PAMPs: TLR: MyD88 : IRAK-1{p}: IRAK-4{p}: TRAF6: IRF-5

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92
Model Detail
659.0, 1231.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p53

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
796.0, 1277.0
31.0, 31.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
755.0, 1236.0
29.0, 29.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
855.0, 1316.0
33.0, 33.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
908.0, 1366.0
28.5, 28.5

ICAM-1

--

G010431

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p61

--

true true true true

csml-variable:Double

m93403

10

false

infinite

0

unit false false false
TRANSFACG010431

--

Go back
594.0, 1406.0
28.5, 28.5

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p80

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
623.0, 1345.0
32.0, 32.0

IFN-alpha

--

G016992

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p71

p72

true true true true

csml-variable:Double

m98717

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
451.0, 1497.0
32.0, 32.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m110

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1056.0, 843.0
31.5, 31.5

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p58 p59 p60 p79

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
737.0, 571.0
28.0, 28.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p88

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1093.0, 706.0
30.0, 30.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
980.0, 473.0
30.0, 30.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p55 p57 p65 p64

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1001.0, 344.0
30.0, 30.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
901.0, 1178.0
30.0, 30.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
421.0, 1105.0
32.0, 32.0

IRF-8

--

MO000007185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m769

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007185

--

Go back
854.0, 570.0
34.0, 34.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p88

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1111.0, 627.0
28.0, 28.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
802.0, 840.0
26.0, 26.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66 p67

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1011.0, 294.0
34.0, 34.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p41 p43 p62 p63

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
987.0, 575.0
36.0, 36.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
868.0, 465.0
29.5, 29.5

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p50

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
689.0, 1707.0
28.0, 28.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p85

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
624.0, 1658.0
30.0, 30.0

IFNalpha

--

MO000016659

cso30:c:Protein

cso30:i:CC_CellComponent

--

p72

--

true true true true

csml-variable:Double

m1635

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
939.0, 707.0
36.0, 36.0

IKK-alpha:IKK-beta:IKK-gamma

--

MO000016661

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m1637

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
899.0, 111.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
744.0, 702.0
29.0, 29.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
128.0, 203.0
31.5, 31.5

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
692.0, 359.0
32.0, 32.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p48

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
915.0, 220.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1123.0, 241.0
32.0, 32.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
277.0, 386.0
25.0, 25.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13 p14 p15

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
418.0, 433.0
27.0, 27.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p24

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
271.0, 1128.0
30.0, 30.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1022.0, 1418.0
28.5, 28.5

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p91 p92

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
872.0, 1506.0
30.5, 30.5

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p89 p91

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
989.0, 1507.0
28.5, 28.5

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p90 p92

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
195.0, 1124.0
29.0, 29.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
397.0, 342.0
34.0, 34.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p87

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
423.0, 1457.0
31.5, 31.5

ERK{p}

--

MO000038306

cso30:c:Protein

cso30:i:CC_CellComponent

--

p84

p80 p81 p82 p83

true true true true

csml-variable:Double

m16522

10

false

infinite

0

unit false false false
TRANSPATHMO000038306

--

Go back
1001.0, 404.0
29.0, 29.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
553.0, 328.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p46

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
884.0, 379.0
32.0, 32.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
456.0, 419.0
31.0, 31.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p46 p85

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
852.0, 720.0
34.0, 34.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51 p88

p52

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
768.0, 1012.0
34.5, 34.5

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p68 p69

p70

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
358.0, 515.0
23.0, 23.0

TLR8(h)

--

MO000042006

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p20 p22

true true true true

csml-variable:Double

m155646

10

false

infinite

0

unit false false false
Affymetrix220832_at
EnsemblENSG00000101916
HGNCTLR8
OMIM300366
ProteomeHumanPSD/TLR8
RefSeqNM_016610
TRANSPATHMO000042006
UnigeneHs.272410
UniProtQ9NR97

--

Go back
357.0, 546.0
26.0, 26.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
360.0, 873.0
27.0, 27.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
171.0, 339.0
28.5, 28.5

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p89 p90

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
372.0, 669.0
28.0, 28.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p19 p21

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
272.0, 1237.0
28.0, 28.0

TLR11

--

MO000042130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19944

10

false

infinite

0

unit false false false
TRANSPATHMO000042130

--

Go back
888.0, 267.0
32.0, 32.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p42

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
253.235360278658, 191.11271154916187
994.1250636573733, 1436.9577763523666

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
258.58757519196735, 243.55747044621057
940.8641055602579, 1317.5604928671248

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1059.0, 1023.0
28.0, 28.0

IRF-5{activated}

--

e100

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

p75

true true true true

csml-variable:Double

m103

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
863.0, 1431.0
28.0, 28.0

IRF-5{nucleus}

--

e101

cso30:c:Protein

cso30:i:CC_CellComponent

--

p75

p76

true true true true

csml-variable:Double

m104

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
742.5, 1438.625
45.0, 12.75

IRF-5: proinflammatory cytokines

--

e102

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p76

p77

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
802.5, 1387.125
52.57760679225259, 11.39181480498806

proinflammatory cytokines

--

e103

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p76

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
744.5, 1329.625
41.007677543186176, 22.5542226487524

proinflammatory cytokines

--

e104

cso30:c:Rna

cso30:i:CC_Nucleoplasm

--

p77

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
497.0, 1045.0
32.0, 32.0

IRF-8{activated}

--

e105

cso30:c:Protein

cso30:i:CC_CellComponent

--

p78

p79

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007185

--

Go back
566.5, 1245.625
41.007677543186176, 22.5542226487524

IL-12p70

--

e106

cso30:c:Rna

cso30:i:CC_Nucleoplasm

--

p81 p82 p83

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
689.5, 1472.0
34.775086505190316, 18.546712802768166

IFN Type I

--

e107

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p86

p85

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
655.375, 414.5
23.97231985940246, 36.880492091388405

RIG-1

--

e108

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p87

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
711.375, 466.5
23.25, 45.0

dsRNA: RIG-1

--

e109

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

p88

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
521.5, 185.125
45.0, 27.75

TLR2: TLR1

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
937.625, 1504.5
27.229253457757043, 33.341943009498415

PGN: Nod1

--

e110

cso30:c:Complex

cso30:i:CC_Cytosol

--

p89

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1056.625, 1503.5
28.739835027495417, 35.191634727545406

PGN: NOD2

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
1134.625, 1407.5
27.44971671388102, 33.611898016997166

protein remnants: NOD1

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

p91

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
1137.625, 1450.5
29.180761539743376, 35.73154474254291

protein remnants: NOD2

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p92

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
566.5, 64.25
45.0, 25.5

tri-acyi lipopeptide

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
326.5, 130.25
45.0, 25.5

Di-acyl lipopeptide

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
386.625, 209.5
30.919971671388105, 37.861189801699716

Di-acyl lipopeptide: TLR2: TLR6

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
577.625, 172.5
29.499208465255787, 36.12147975337444

tri-acyi lipopeptide: TLR2: TLR1

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1117.5, 138.375
37.794376098418276, 24.56634446397188

PAMPs

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1175.625, 226.5
32.87964505915681, 40.260789868355275

PAMP: TLR

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p25

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
267.625, 1168.5
36.75, 45.0

flagellin: TLR5

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p83

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
267.625, 1284.5
36.75, 45.0

uropathogenic bacterial ligand: TLR11

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
253.235360278658, 191.11271154916187
994.1250636573733, 1436.9577763523666

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
190.5, 1242.375
38.11072056239016, 24.771968365553608

uropathogenic bacterial ligand

--

e20

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
196.5, 925.125
45.0, 15.75

CpG DNA

--

e21

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
369.625, 914.5
31.00979003499417, 37.97117147142143

CpG DNA: TLR9

--

e22

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

p62 p78 p81

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
426.625, 975.5
28.739835027495417, 35.191634727545406

homozoin: TLR9

--

e23

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p9

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
334.5, 1078.25
45.0, 25.5

homozoin

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
159.5, 672.625
37.93666026871401, 20.865163147792707

viral ssRNA

--

e25

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p10 p11

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
359.625, 581.5
29.139935010831525, 35.68155307448758

viral ssRNA: TLR8

--

e26

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p10

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
372.625, 706.5
26.829153474420924, 32.85202466255624

viral ssRNA: TLR7

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

p63

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
278.625, 336.5
31.00979003499417, 37.97117147142143

PGN: TLR2

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
159.5, 382.25
45.0, 25.5

lipopeptides

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
273.1178615518054, 210.9055183859714
954.3600611110786, 1397.372162678749

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
275.625, 425.5
28.739835027495417, 35.191634727545406

lipopeptides: TLR2

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
272.625, 200.5
30.699508415264123, 37.591234794200965

Lp: TLR2

--

e31

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p14

p42 p84

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
274.375, 298.5
26.554042179261863, 40.85237258347979

dectin-1

--

e32

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p15

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
126.5, 307.375
34.31458699472759, 22.304481546572934

zymosan

--

e33

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
271.875, 248.5
32.25, 45.0

zymosan: TLR2: dectin-1

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p15

p17

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
145.5, 1361.375
32.69771528998242, 21.253514938488575

TLR ligands

--

e35

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p16

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
228.625, 1403.5
27.359898350274957, 33.501916347275454

TLR2 ligands: CD36

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
226.5, 1360.125
31.240000000000002, 23.429999999999996

CD36

--

e37

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p16

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
514.5, 1375.0
37.88927335640139, 20.207612456747405

target genes

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
169.5, 631.25
41.54331370899916, 23.541211101766187

resiquimod

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p18 p19

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
309.9004889071284, 245.5429303503878
880.794806400433, 1328.0973387499146

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
368.625, 626.5
27.139435094150972, 33.2319613397767

resiquimod: TLR8{h}

--

e40

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p18

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
368.625, 742.5
26.86998000333278, 32.90201633061156

resiquimod: TLR7

--

e41

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p19

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
163.5, 566.25
45.0, 25.5

imiquimod

--

e42

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p20 p21

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
366.625, 468.5
29.8993084485919, 36.61139810031661

imiquimod: TLR8{h}

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p20

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
363.875, 779.5
27.578317122407782, 38.48137272894109

imiquimod: TLR7

--

e44

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p21

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
159.5, 490.25
45.0, 25.5

loxoribine

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p22 p23

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
381.875, 431.5
27.578317122407782, 38.48137272894109

loxoribine: TLR8{h}

--

e46

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p22

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
362.875, 822.5
29.606395668930077, 41.311249770600114

loxoribine: TLR8{h}

--

e47

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p23

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
514.625, 410.5
27.359898350274957, 33.501916347275454

West Nile Viru sligand: TLR3

--

e48

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p24

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
489.5, 127.375
36.810193321616865, 23.926625659050966

West Nile Viru sligand

--

e49

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p24

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
950.5, 201.0
35.674220963172814, 43.68271954674222

LPS: TLR4

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p1

p40 p44 p60 p82

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
470.6093863085075, 1062.4806288660443
501.81422916891995, 453.0373566530216

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
524.8090609673479, 1073.2169556059991
293.42582487717107, 439.0834339635035

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
477.15072635354, 1068.527328698169
488.731549078855, 440.9439569887724

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
478.08520350283015, 1069.4575902108036
486.8625947802741, 439.0834339635035

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
470.6093863085075, 1062.4806288660443
501.81422916891995, 453.0373566530216

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
470.6093863085075, 1062.4806288660443
501.81422916891995, 453.0373566530216

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
478.08520350283015, 1069.4575902108036
486.8625947802741, 439.0834339635035

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
836.9244288303257, 1248.5329313929526
31.350595818147614, 28.252508374156434

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
754.6904396927753, 1378.7695431617885
88.77532918258358, 80.00249008657057

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
470.6093863085075, 1062.4806288660443
501.81422916891995, 453.0373566530216

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
332.5, 224.125
45.0, 27.75

TLR2: TLR6

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
588.884176609301, 1263.8066866841516
15.891719299222823, 7.617050604319117

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
588.353507119092, 1241.090839291877
54.39362274642907, 97.46683357848309

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
611.1722951980821, 1304.4839017819472
8.490711843345013, 8.452408332009368

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1175.875, 280.5
32.25, 45.0

PAMPs: TLR: MyD88

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25 p29

p26

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1175.875, 336.5
32.25, 45.0

PAMPs: TLR: MyD88 : IRAK-1: IRAK-4

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

p27

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1177.875, 388.5
32.25, 45.0

PAMPs: TLR: MyD88 : IRAK-1: IRAK-4{p}

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p28

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1007.875, 188.5
32.25, 45.0

LPS: TLR4: MAL

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

p41

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1173.875, 445.5
36.645485410167005, 51.13323545604698

PAMPs: TLR: MyD88 : IRAK-1{p}: IRAK-4{p}

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1056.875, 456.5
27.980776289227382, 39.04294365938704

IRAK-1{p}: IRAK-4{p}

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p30

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
982.875, 509.5
32.25, 45.0

IRAK-1{p}: IRAK-4{p}: TRAF6

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
265.98838061498896, 196.7586401978105
951.912344505629, 1342.7503049612155

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
991.875, 620.5
32.25, 45.0

IRAK-1{p}: IRAK-4{p}: TRAF6: TAK1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p32 p33

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1093.0, 754.0
30.0, 30.0

MAPKs{activated}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p35

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
998.0, 765.0
36.0, 36.0

IKK-alpha:IKK-beta:IKK-gamma{activated}

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

p34

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1004.0, 951.0
31.5, 31.5

NF-kappaB{activated}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34 p58 p59 p60 p79

p36

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
905.0, 1226.0
30.0, 30.0

AP-1{activated}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
829.0, 1149.0
31.5, 31.5

NF-kappaB{nucleus}

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p37 p38 p39 p61

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1051.875, 172.5
32.25, 45.0

LPS: TLR4: MAL: MyD88

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
467.875, 204.5
32.25, 45.0

Lp: TLR2: MAL

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p43

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
423.875, 184.5
32.25, 45.0

Lp: TLR2: MAL: MyD88

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
851.875, 164.5
32.85763442833547, 45.84786199302624

LPS: TLR4: TRAM

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

p45

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
269.38918603801045, 220.45688557041052
913.1808548531599, 1319.9569939115863

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
799.875, 172.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p45

p47 p49 p55

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
607.875, 472.5
32.25, 45.0

dsRNA: TLR3: TRIF

--

e81

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p46

p48 p50 p56

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
696.0, 403.0
32.0, 32.0

TBK1{activated}

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47 p48

p51

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
869.0, 523.0
29.5, 29.5

IKK-i{activated}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p50

p51

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
764.0, 1100.0
34.0, 34.0

IRF-3{p}{nucleus}

--

e84

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p53 p54 p86

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
691.5, 1286.0
42.24913494809689, 22.53287197231834

IFN inducible gene

--

e85

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p54

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
747.5, 183.0
33.86970086254359, 47.2600477151771

LPS: TLR4: TRAM: TRIF

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p55

p58

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
650.875, 532.5
26.22100385391815, 36.58744723802533

dsRNA: TLR3: TRIF: RIP1

--

e87

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p56

p57

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
678.875, 597.5
27.578317122407782, 38.48137272894109

dsRNA: TLR3: TRIF: RIP1: TRAF6

--

e88

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p57

p59

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
689.875, 652.5
29.472242613323544, 41.12405946045146

viral ssRNA: TLR7: MyD88

--

e89

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p63

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
278.45800049940135, 244.1551309430106
909.011683339649, 1302.6460886877314

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
613.875, 912.5
29.606395668930077, 41.311249770600114

CpG DNA: TLR9: MyD88

--

e90

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p62

p65

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
682.875, 750.5
39.841484676087354, 55.59276931547073

viral ssRNA: TLR7: MyD88: IRAK-1{p}: IRAK-4{p}

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p64

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
667.875, 812.5
34.751559919251235, 48.49054872453661

viral ssRNA: TLR7: MyD88: IRAK-1{p}: IRAK-4{p}: TRAF6

--

e92

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p64 p69

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
566.875, 943.5
36.10887318774087, 50.38447421545238

CpG DNA: TLR9: MyD88: IRAK-1{p}: IRAK-4{p}

--

e93

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p65

p67

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
640.875, 862.5
30.829555881813178, 43.017984951367225

CpG DNA: TLR9: MyD88: IRAK-1{p}: IRAK-4{p}: TRAF6

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65 p68

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
693.875, 700.5
29.87470178014314, 41.685630390897416

viral ssRNA: TLR7: MyD88: IRAK-1{p}: IRAK-4{p}: TRAF6: IRF-7

--

e95

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p66

p69

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
497.875, 965.5
39.15493668563039, 54.634795375298225

CpG DNA: TLR9: MyD88: IRAK-1{p}: IRAK-4{p}: IRF-7

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p68

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
648.0, 1116.0
34.5, 34.5

IRF-7{p}{nucleus}

--

e97

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

p71

true true true true

csml-variable:Double

m100

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
1173.875, 562.5
38.136951734263164, 53.214351257111396

PAMPs: TLR: MyD88 : IRAK-1{p}: IRAK-4{p}: TRAF6

--

e98

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p74

p73

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1174.875, 673.5
44.505276197467424, 62.10038539181502

PAMPs: TLR: MyD88 : IRAK-1{p}: IRAK-4{p}: TRAF6: IRF-5

--

e99

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p73

p74

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
954.0, 114.0
26.0, 26.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR4 recognizes bacterial LPS.

Go back
244.0, 585.0
27.0, 27.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e25 MO000042007

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c33 : 1

m26*m19823*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR3, TLR7, TLR8 and TLR9 reside in endosomal compartments and recognize nucleic acids; TLR3 recognizes viral dsRNA, whereas TLR7 and TLR8 recognize viral ssRNA.

Go back
251.0, 671.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e25 MO000042126

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m26*m19940*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR3, TLR7, TLR8 and TLR9 reside in endosomal compartments and recognize nucleic acids; TLR3 recognizes viral dsRNA, whereas TLR7 and TLR8 recognize viral ssRNA.

Go back
225.0, 342.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042032 MO000019397

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m155701*m3964*0.1

nodelay

--

true

0

false

PMID: 15950447, 12524386, 10549626 TLR2 recognizes peptidoglycan, in addition to the lipoproteins and lipopeptides of Gram-positive bacteria and mycoplasma lipopeptide.

Go back
226.0, 387.0
23.0, 23.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m3964*m30*0.1

nodelay

--

true

0

false

PMID: 15950447, 12524386, 10549626 TLR2 recognizes peptidoglycan, in addition to the lipoproteins and lipopeptides of Gram-positive bacteria and mycoplasma lipopeptide.

Go back
199.0, 206.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000017793

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m3964*m2549*0.1

nodelay

--

true

0

false

PMID: 15950447, 12524386, 10549626 TLR2 recognizes peptidoglycan, in addition to the lipoproteins and lipopeptides of Gram-positive bacteria and mycoplasma lipopeptide.

Go back
216.0, 307.0
24.0, 24.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 e33 MO000019397

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m33*m34*m3964*0.1

nodelay

--

true

0

false

PMID: 15950447, 12719479 Innate immune responses against zymosan, a cell-wall preparation of yeast, are mediated by the collaborative recognition of TLR2 and dectin-1, a lectin family of receptors for beta-glucans.

Go back
149.0, 1407.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e37 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m38*m36*0.1

nodelay

--

true

0

false

PMIID: 15950447, 15690042 CD36, a class II scavenger receptor expressed on the surface of innate immune cells, is involved in sensing some, but not all, TLR2 ligands.

Go back
520.0, 1324.0
25.0, 25.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15950447 Signaling through dectin-1 enhanced the TLR2-mediated transcription of target genes.

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246.0, 631.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e39 MO000042006

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c52 : 1
stoichiometry:c54 : 1

m40*m155646*0.1

nodelay

--

true

0

false

PMID: 15950447, 12032557 TLR8 is a close relative of TLR7, and a transfection study has demonstrated that human, but not mouse, TLR8 confers responsiveness to resiquimod.

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250.0, 746.0
26.0, 26.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e39 MO000042126

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m40*m19940*0.1

nodelay

--

true

0

false

PMID: 15950447 Synthetic imidazoquinoline-like molecules imiquimod (R-837) and resiquimod (R-848), and guanosine analogs such as loxoribine, have potent antiviral activities and are currently used for treating viral infections. PMID: 15950447 Taken together, these findings indicate that mouse TLR7, human TLR7 and human TLR8 mediate the recognition of these molecules.

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456.0, 345.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR3 recognizes viral dsRNA.

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246.0, 515.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e42 MO000042006

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m43*m155646*0.1

nodelay

--

true

0

false

PMID: 15950447 Synthetic imidazoquinoline-like molecules imiquimod (R-837) and resiquimod (R-848), and guanosine analogs such as loxoribine, have potent antiviral activities and are currently used for treating viral infections. PMID: 15950447 Taken together, these findings indicate that mouse TLR7, human TLR7 and human TLR8 mediate the recognition of these molecules.

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134.0, 787.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 MO000042126

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m43*m19940*0.1

nodelay

--

true

0

false

PMID: 15950447 Synthetic imidazoquinoline-like molecules imiquimod (R-837) and resiquimod (R-848), and guanosine analogs such as loxoribine, have potent antiviral activities and are currently used for treating viral infections. PMID: 15950447 Taken together, these findings indicate that mouse TLR7, human TLR7 and human TLR8 mediate the recognition of these molecules.

Go back
247.0, 472.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e45 MO000042006

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m46*m155646*0.1

nodelay

--

true

0

false

PMID: 15950447 Synthetic imidazoquinoline-like molecules imiquimod (R-837) and resiquimod (R-848), and guanosine analogs such as loxoribine, have potent antiviral activities and are currently used for treating viral infections. PMID: 15950447 Taken together, these findings indicate that mouse TLR7, human TLR7 and human TLR8 mediate the recognition of these molecules.

Go back
122.0, 831.0
23.0, 23.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 15950447 Synthetic imidazoquinoline-like molecules imiquimod (R-837) and resiquimod (R-848), and guanosine analogs such as loxoribine, have potent antiviral activities and are currently used for treating viral infections. PMID: 15950447 Taken together, these findings indicate that mouse TLR7, human TLR7 and human TLR8 mediate the recognition of these molecules.

Go back
494.0, 345.0
27.0, 27.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 e49

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m3965*m63*0.1

nodelay

--

true

0

false

PMID: 15950447, 15558055 TLR3 also mediates the recognition of West Nile virus (WNV).

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1103.0, 290.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016573

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 15950447 MyD88 is utilized by all TLRs, with the exception of TLR3.

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1104.0, 347.0
23.0, 23.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e63 MO000039077

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m184*m64*m17258*0.1

nodelay

--

true

0

false

PMID: 15950447 The association of TLRs and MyD88 recruits members of the IL-1 receptor-associated kinase (IRAK) family; two members, IRAK4 and IRAK1, are sequentially phosphorylated, causing them to dissociate from the receptor complex, and then associate with TRAF6.

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1250.0, 345.0
27.0, 27.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 15950447 The association of TLRs and MyD88 recruits members of the IL-1 receptor-associated kinase (IRAK) family; two members, IRAK4 and IRAK1, are sequentially phosphorylated, causing them to dissociate from the receptor complex, and then associate with TRAF6.

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1249.0, 398.0
25.0, 25.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e65

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15950447 The association of TLRs and MyD88 recruits members of the IL-1 receptor-associated kinase (IRAK) family; two members, IRAK4 and IRAK1, are sequentially phosphorylated, causing them to dissociate from the receptor complex, and then associate with TRAF6.

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1115.0, 462.0
25.0, 25.0

p29

p29

cso30:i:ME_Dissociation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e67

e68 e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 15950447 The association of TLRs and MyD88 recruits members of the IL-1 receptor-associated kinase (IRAK) family; two members, IRAK4 and IRAK1, are sequentially phosphorylated, causing them to dissociate from the receptor complex, and then associate with TRAF6.

Go back
388.0, 130.0
27.0, 27.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e6

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m6*0.1

nodelay

--

true

0

false

PMID: 15950447 Structures and ligands for Toll-like receptors. TLR2, in collaboration with TLR1 or TLR6, discriminates between the molecular structures of triacyl and diacyl lipopeptides, respectively.

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1058.0, 519.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e68 MO000000212

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m69*m183*0.1

nodelay

--

true

0

false

PMID: 15950447 The association of TLRs and MyD88 recruits members of the IL-1 receptor-associated kinase (IRAK) family; two members, IRAK4 and IRAK1, are sequentially phosphorylated, causing them to dissociate from the receptor complex, and then associate with TRAF6.

Go back
1059.0, 579.0
27.0, 27.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000016574

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m70*m1573*0.1

nodelay

--

true

0

false

PMID: 15950447 TRAF6 forms a complex with ubiquitin-conjugating enzymes to activate the kinase TAK1, which in turn activates transcription factors nuclear factor (NF)-kappaB and activator protein-1 through the canonical IkappaB kinase (IKK) complex and the mitogen-activated protein kinase pathway, respectively.

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1039.0, 708.0
26.0, 26.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 MO000000077

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m71*m72*0.1

nodelay

--

true

0

false

PMID: 15950447 TRAF6 forms a complex with ubiquitin-conjugating enzymes to activate the kinase TAK1, which in turn activates transcription factors nuclear factor (NF)-kappaB and activator protein-1 through the canonical IkappaB kinase (IKK) complex and the mitogen-activated protein kinase pathway, respectively.

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1000.0, 712.0
25.0, 25.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 MO000016661

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m71*m1637*0.1

nodelay

--

true

0

false

PMID: 15950447 TRAF6 forms a complex with ubiquitin-conjugating enzymes to activate the kinase TAK1, which in turn activates transcription factors nuclear factor (NF)-kappaB and activator protein-1 through the canonical IkappaB kinase (IKK) complex and the mitogen-activated protein kinase pathway, respectively.

Go back
1006.0, 846.0
25.0, 25.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m19*m74*0.1

nodelay

--

true

0

false

PMID: 15950447 TRAF6 forms a complex with ubiquitin-conjugating enzymes to activate the kinase TAK1, which in turn activates transcription factors nuclear factor (NF)-kappaB and activator protein-1 through the canonical IkappaB kinase (IKK) complex and the mitogen-activated protein kinase pathway, respectively.

Go back
978.0, 1178.0
27.0, 27.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e71

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c105 : 1
stoichiometry:c102 : 1

m219*m73*0.1

nodelay

--

true

0

false

PMID: 15950447 TRAF6 forms a complex with ubiquitin-conjugating enzymes to activate the kinase TAK1, which in turn activates transcription factors nuclear factor (NF)-kappaB and activator protein-1 through the canonical IkappaB kinase (IKK) complex and the mitogen-activated protein kinase pathway, respectively.

Go back
904.0, 1072.0
25.0, 25.0

p36

p36

cso30:i:ME_Translocation

cso30:i:CC_NuclearInnerMembrane

--

e73

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 15950447, 15229469, 10435584 NF-kappaB activation by this ¡ÆMyD88-dependent pathway¡Ç results in the expression of inflammatory cytokine genes, including tumor necrosis factor-alpha, IL-6 and IL-1beta.

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754.0, 1183.0
27.0, 27.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e75

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c106 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 15950447, 15229469, 10435584 NF-kappaB activation by this ¡ÆMyD88-dependent pathway¡Ç results in the expression of inflammatory cytokine genes, including tumor necrosis factor-alpha, IL-6 and IL-1beta.

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798.0, 1211.0
27.0, 27.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e75

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c107 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 15950447, 15229469, 10435584 NF-kappaB activation by this ¡ÆMyD88-dependent pathway¡Ç results in the expression of inflammatory cytokine genes, including tumor necrosis factor-alpha, IL-6 and IL-1beta.

Go back
859.0, 1256.0
25.0, 25.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearBody

--

e75

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c108 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 15950447, 15229469, 10435584 NF-kappaB activation by this ¡ÆMyD88-dependent pathway¡Ç results in the expression of inflammatory cytokine genes, including tumor necrosis factor-alpha, IL-6 and IL-1beta.

Go back
580.0, 107.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e11

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m12*m11*0.1

nodelay

--

true

0

false

PMID: 15950447 Structures and ligands for Toll-like receptors. TLR2, in collaboration with TLR1 or TLR6, discriminates between the molecular structures of triacyl and diacyl lipopeptides, respectively.

Go back
955.0, 270.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000068831

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m5*m43675*0.1

nodelay

--

true

0

false

PMID: 15950447, 12447441, 12447442 Among these adapters, TIRAP?MAL is required for the activation of the MyD88-dependent pathway downstream of TLR2 and TLR4.

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1054.0, 253.0
27.0, 27.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 MO000016573

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m67*m1572*0.1

nodelay

--

true

0

false

PMID: 15950447, 12447441, 12447442 Among these adapters, TIRAP?MAL is required for the activation of the MyD88-dependent pathway downstream of TLR2 and TLR4.

Go back
522.0, 269.0
27.0, 27.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 e31

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c118 : 1
stoichiometry:c120 : 1

m43675*m32*0.1

nodelay

--

true

0

false

PMID: 15950447, 12447441, 12447442 Among these adapters, TIRAP?MAL is required for the activation of the MyD88-dependent pathway downstream of TLR2 and TLR4.

Go back
426.0, 297.0
27.0, 27.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m1572*m79*0.1

nodelay

--

true

0

false

PMID: 15950447, 12447441, 12447442 Among these adapters, TIRAP?MAL is required for the activation of the MyD88-dependent pathway downstream of TLR2 and TLR4.

Go back
887.0, 330.0
25.0, 25.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000041132

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m5*m19005*0.1

nodelay

--

true

0

false

PMID: 15950447, 14556004 Additionally, TLR4 also requires another adaptor, TRAM, for IRF3 activation.

Go back
857.0, 332.0
22.0, 22.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e79 MO000041125

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m81*m18998*0.1

nodelay

--

true

0

false

PMID: 15950447, 12855817, 12872135 It has been demonstrated that TRIF is responsible for TLR3- and TLR4-mediated IRF3 activation.

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554.0, 433.0
27.0, 27.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041446

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 15950447, 12855817, 12872135 It has been demonstrated that TRIF is responsible for TLR3- and TLR4-mediated IRF3 activation.

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760.0, 364.0
25.0, 25.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e80

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c141 : 1
stoichiometry:c134 : 1

m3902*m82*0.1

nodelay

--

true

0

false

PMID: 15950447, 12692549, 12702806 IRF3 activation occurs through the actions of the IKK-related kinases TRAF-family-member-associated NF-¦ÊB activator (TANK)-binding kinase 1 (TBK1) and IKKi (also called IKKvar epsilon), which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

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759.0, 403.0
27.0, 27.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c143 : 1
stoichiometry:c136 : 1

m3902*m83*0.1

nodelay

--

true

0

false

PMID: 15950447, 12692549, 12702806 IRF3 activation occurs through the actions of the IKK-related kinases TRAF-family-member-associated NF-¦ÊB activator (TANK)-binding kinase 1 (TBK1) and IKKi (also called IKKvar epsilon), which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

Go back
796.0, 465.0
29.0, 29.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e80

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c142 : 1
stoichiometry:c138 : 1

m1599*m82*0.1

nodelay

--

true

0

false

PMID: 15950447, 12692549, 12702806 IRF3 activation occurs through the actions of the IKK-related kinases TRAF-family-member-associated NF-¦ÊB activator (TANK)-binding kinase 1 (TBK1) and IKKi (also called IKKvar epsilon), which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

Go back
1179.0, 138.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e16 MO000019395

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m16*m3962*0.1

nodelay

--

true

0

false

PMID: 15950447, 12524386 All TLRs possess amino-terminal leucine-rich repeats, which are responsible for the recognition of PAMPs, and also possess a carboxy-terminal Toll?interleukin-1 (IL-1) receptor (TIR) domain, which is required for initiating intracellular signaling.

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803.0, 525.0
25.0, 25.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e81

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c144 : 1
stoichiometry:c140 : 1

m1599*m83*0.1

nodelay

--

true

0

false

PMID: 15950447, 12692549, 12702806 IRF3 activation occurs through the actions of the IKK-related kinases TRAF-family-member-associated NF-¦ÊB activator (TANK)-binding kinase 1 (TBK1) and IKKi (also called IKKvar epsilon), which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

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797.0, 575.0
27.0, 27.0

p51

p51

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e83 e82

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c146 : 1

m977*m85*m84*0.1

nodelay

--

true

0

false

PMID: 15950447, 12692549, 12702806 IRF3 activation occurs through the actions of the IKK-related kinases TRAF-family-member-associated NF-¦ÊB activator (TANK)-binding kinase 1 (TBK1) and IKKi (also called IKKvar epsilon), which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

Go back
855.0, 991.0
27.0, 27.0

p52

p52

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041456

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 15950447, 12692549, 12702806 IRF3 activation occurs through the actions of the IKK-related kinases TRAF-family-member-associated NF-¦ÊB activator (TANK)-binding kinase 1 (TBK1) and IKKi (also called IKKvar epsilon), which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

Go back
662.0, 1182.0
22.0, 22.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e84

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c151 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 15950447, 11698465, 12855817 Stimulation of macrophages and DCs with LPS and dsRNA results in the activation of the transcription factor IFN regulatory factor 3 (IRF3) and subsequent induction of IFN-beta and IFN-inducible genes.

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701.0, 1193.0
24.0, 24.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c152 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 15950447, 11698465, 12855817 Stimulation of macrophages and DCs with LPS and dsRNA results in the activation of the transcription factor IFN regulatory factor 3 (IRF3) and subsequent induction of IFN-beta and IFN-inducible genes.

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830.0, 376.0
25.0, 25.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e80

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m183*m82*0.1

nodelay

--

true

0

false

PMID: 15950447, 14530355 TRAF6 is also reported to bind TRIF and cooperatively activate NF-kappaB.

Go back
701.0, 527.0
27.0, 27.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 e81

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m88*m83*0.1

nodelay

--

true

0

false

PMID: 15950447, 14530355, 15064760 Furthermore, TRIF interacts with two different protein kinases, TBK1 and receptor-interacting protein-1 (RIP1).

Go back
739.0, 605.0
23.0, 23.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m183*m90*0.1

nodelay

--

true

0

false

PMID: 15950447, 14530355 TRAF6 is also reported to bind TRIF and cooperatively activate NF-kappaB.

Go back
1059.0, 954.0
25.0, 25.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e86

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c169 : 1
stoichiometry:c165 : 1

m19*m89*0.1

nodelay

--

true

0

false

PMID: 15950447, 11698465 However, cells doubly deficient in TRAF6 and MyD88 still partially activated NF-kappaB in response to LPS, suggesting that TRIF activates NF-kappaB through both TRAF6-dependent and -independent pathways in TLR4 signaling.

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971.0, 898.0
25.0, 25.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e88

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c168 : 1
stoichiometry:c167 : 1

m19*m91*0.1

nodelay

--

true

0

false

PMID: 15950447 Thus, TRIF is likely to use TBK1 and RIP1 for IRF3- and NF-kappaB activation, respectively, in TLR3 signaling. PMID: 15950447 In cells lacking RIP1, TLR3-mediated NF-kappaB activation and the subsequent induction of Icam-1 was severely impaired, whereas IFNbeta induction was intact.

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197.0, 1178.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR5 recognizes bacterial flagellin.

Go back
1119.0, 886.0
25.0, 25.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e5

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c172 : 1
stoichiometry:c171 : 1

m19*m5*0.1

nodelay

--

true

0

false

PMID: 15950447, 11698465 However, cells doubly deficient in TRAF6 and MyD88 still partially activated NF-kappaB in response to LPS, suggesting that TRIF activates NF-kappaB through both TRAF6-dependent and -independent pathways in TLR4 signaling.

Go back
908.0, 1302.0
24.0, 24.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e75

G010431

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 15950447 In cells lacking RIP1, TLR3-mediated NF-kappaB activation and the subsequent induction of Icam-1 was severely impaired, whereas IFNbeta induction was intact.

Go back
455.0, 919.0
27.0, 27.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e22

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m1572*m23*0.1

nodelay

--

true

0

false

PMID: 15950447, 12626561 It appears that IFN-alpha induction by TLR7 and TLR9 depends entirely on MyD88.

Go back
446.0, 661.0
23.0, 23.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e27

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m1572*m28*0.1

nodelay

--

true

0

false

PMID: 15950447, 12626561 It appears that IFN-alpha induction by TLR7 and TLR9 depends entirely on MyD88.

Go back
745.0, 769.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m183*m94*0.1

nodelay

--

true

0

false

PMID: 15950447, 15361868, 15492225 IRF7 forms a signaling complex with MyD88 and TRAF6 in the cytoplasm.

Go back
688.0, 920.0
25.0, 25.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e90 MO000000212

e93 e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c187 : 1
stoichiometry:c186 : 1
stoichiometry:c188 : 1

m93*m183*0.1

nodelay

--

true

0

false

PMID: 15950447, 15361868, 15492225 IRF7 forms a signaling complex with MyD88 and TRAF6 in the cytoplasm.

Go back
803.0, 777.0
23.0, 23.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007702

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c192 : 1

m980*0.1

nodelay

--

true

0

false

PMID: 15950447, 15361868, 15492225 IRF7 forms a signaling complex with MyD88 and TRAF6 in the cytoplasm.

Go back
687.0, 979.0
27.0, 27.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007702 e93

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m980*m96*0.1

nodelay

--

true

0

false

PMID: 15950447, 15361868, 15492225 IRF7 forms a signaling complex with MyD88 and TRAF6 in the cytoplasm.

Go back
631.0, 1015.0
27.0, 27.0

p68

p68

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e96

MO000041457 e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c198 : 1

m99*0.1

nodelay

--

true

0

false

PMID: 15950447 Similar to IRF3, phosphorylation is required for the activation of IRF7. PMID: 15950447, 15767370 In this regard, IRAK1 has been demonstrated to serve as an IRF7 kinase, and in IRAK1-deficient mice, TLR7- and TLR9-induced IFN-alpha production was completely abolished, although inflammatory cytokines were produced.

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771.0, 927.0
27.0, 27.0

p69

p69

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e95

MO000041457 e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m98*0.1

nodelay

--

true

0

false

PMID: 15950447 Similar to IRF3, phosphorylation is required for the activation of IRF7. PMID: 15950447, 15767370 In this regard, IRAK1 has been demonstrated to serve as an IRF7 kinase, and in IRAK1-deficient mice, TLR7- and TLR9-induced IFN-alpha production was completely abolished, although inflammatory cytokines were produced.

Go back
197.0, 1294.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042130 e20

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19944*m21*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR11 recognizes uropathigenic bacteria products.

Go back
704.0, 1064.0
25.0, 25.0

p70

p70

cso30:i:ME_Translocation

cso30:i:CC_NuclearEnvelopeLumen

--

MO000041457

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 15950447, 15361868, 15492225 After stimulation, IRF7 translocates into the nucleus to induce IFN-alpha.

Go back
626.0, 1176.0
26.0, 26.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e97

G016992

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c201 : 1

m100*0.1

nodelay

--

true

0

false

PMID: 15950447, 15361868, 15492225 After stimulation, IRF7 translocates into the nucleus to induce IFN-alpha.

Go back
623.0, 1531.0
31.0, 31.0

p72

p72

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G016992

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c203 : 1

m98717*0.1

nodelay

--

true

0

false

PMID: 15950447 Accordingly, pDCs respond to CpG DNA, by rapidly secreting large amounts of IFN-alpha. Synthesized ssRNA can also induce IFN-alpha via TLR7.

Go back
1112.0, 576.0
25.0, 25.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e98 MO000007700

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m101*m979*0.1

nodelay

--

true

0

false

PMID: 15950447, 15665823, 15695821 More recently, IRF5 has been shown to be involved in a MyD88?TRAF6 complex.

Go back
1127.0, 1023.0
27.0, 27.0

p74

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e99

e100 e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m102*0.1

nodelay

--

true

0

false

--

Go back
983.0, 1431.0
25.0, 25.0

p75

p75

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e100

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 15950447, 15665823 Upon TLR ligand stimulation, IRF5 was shown to translocate to the nucleus from the cytoplasm and bind the potential IFN-stimulated response element (ISRE) motifs present in the promoter region of proinflammatory cytokine genes.

Go back
815.0, 1431.0
27.0, 27.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Nucleolus

--

e103 e101

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c215 : 1
stoichiometry:c214 : 1

m106*m104*0.1

nodelay

--

true

0

false

PMID: 15950447, 15665823 Upon TLR ligand stimulation, IRF5 was shown to translocate to the nucleus from the cytoplasm and bind the potential IFN-stimulated response element (ISRE) motifs present in the promoter region of proinflammatory cytokine genes.

Go back
753.0, 1385.0
24.0, 24.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e102

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 15950447 These observations indicate that IRF5 is a general signal transducer that mediates MyD88-dependent gene induction of proinflammatory cytokines, in contrast to IRF7, which requires MyD88-dependent IFN-alpha induction.

Go back
424.0, 1048.0
25.0, 25.0

p78

p78

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007185 e22

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c220 : 1
stoichiometry:c219 : 1

m769*m23*0.1

nodelay

--

true

0

false

PMID: 15950447, 15153500 In these cells, TLR9-stimulated NF-kappaB activation was unexpectedly impaired, suggesting that IRF8 mediates NF-kappaB activation in TLR9 signaling.

Go back
951.0, 951.0
27.0, 27.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e105

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c223 : 1
stoichiometry:c222 : 1

m19*m108*0.1

nodelay

--

true

0

false

PMID: 15950447, 15153500 In these cells, TLR9-stimulated NF-kappaB activation was unexpectedly impaired, suggesting that IRF8 mediates NF-kappaB activation in TLR9 signaling.

Go back
265.0, 874.0
27.0, 27.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e21 MO000042012

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m22*m19828*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR9 recognizes bacterial and viral CpG DNA motifs.

Go back
597.0, 1461.0
22.0, 22.0

p80

p80

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000038306

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c225 : 1

m16522*0.1

nodelay

--

true

0

false

PMID: 15950447, 14978071, 15067049 For example, various TLR2 ligands induce abundant IL-10 and favor Th2-biased immune responses both in human and mice, whereas ligands for TLR4, TLR5 and TLR9 induce Th1-associated cytokines, such as IL-12p70. PMID: 15950447 It was demonstrated that TLR2 ligands induce a higher phosphorylation of ERK and stabilization of the transcription factor c-Fos in DCs, which results in induction of IL-10 and suppression of IL-12p70.

Go back
518.0, 1192.0
25.0, 25.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22 MO000038306

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c237 : 1
stoichiometry:c229 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 15950447, 14978071, 15067049 For example, various TLR2 ligands induce abundant IL-10 and favor Th2-biased immune responses both in human and mice, whereas ligands for TLR4, TLR5 and TLR9 induce Th1-associated cytokines, such as IL-12p70. PMID: 15950447 It was demonstrated that TLR2 ligands induce a higher phosphorylation of ERK and stabilization of the transcription factor c-Fos in DCs, which results in induction of IL-10 and suppression of IL-12p70.

Go back
510.0, 1234.0
25.0, 25.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 MO000038306

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c236 : 1
stoichiometry:c230 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 15950447, 14978071, 15067049 For example, various TLR2 ligands induce abundant IL-10 and favor Th2-biased immune responses both in human and mice, whereas ligands for TLR4, TLR5 and TLR9 induce Th1-associated cytokines, such as IL-12p70. PMID: 15950447 It was demonstrated that TLR2 ligands induce a higher phosphorylation of ERK and stabilization of the transcription factor c-Fos in DCs, which results in induction of IL-10 and suppression of IL-12p70.

Go back
509.0, 1273.0
23.0, 23.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18 MO000038306

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c235 : 1
stoichiometry:c231 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 15950447, 14978071, 15067049 For example, various TLR2 ligands induce abundant IL-10 and favor Th2-biased immune responses both in human and mice, whereas ligands for TLR4, TLR5 and TLR9 induce Th1-associated cytokines, such as IL-12p70. PMID: 15950447 It was demonstrated that TLR2 ligands induce a higher phosphorylation of ERK and stabilization of the transcription factor c-Fos in DCs, which results in induction of IL-10 and suppression of IL-12p70.

Go back
350.0, 1500.0
25.0, 25.0

p84

p84

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e31 MO000000011

MO000038306

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c224 : 1
stoichiometry:c233 : 1

m32*m110*0.1

nodelay

--

true

0

false

PMID: 15950447 It was demonstrated that TLR2 ligands induce a higher phosphorylation of ERK and stabilization of the transcription factor c-Fos in DCs, which results in induction of IL-10 and suppression of IL-12p70.

Go back
690.0, 1536.0
25.0, 25.0

p85

p85

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000041446 e107

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c240 : 1
stoichiometry:c239 : 1

m19314*m111*0.1

nodelay

--

true

0

false

PMID: 15950447 For example, intracellular introduction of dsRNA stimulates DCs lacking TLR3 to secrete type I IFN.

Go back
692.0, 1394.0
27.0, 27.0

p86

p86

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e84

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 15950447, 12855817, 15210742 TRIF but does require TBK1 and IRF3.

Go back
590.0, 404.0
25.0, 25.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e108

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m119368*m112*0.1

nodelay

--

true

0

false

PMID: 15950447, 15208624 Retinoic acid-inducible gene I has recently been identified as an intracellular sensor for dsRNA, and is composed of the RNA helicase domain, which binds dsRNA, and the caspase recruitment domain (CARD), which culminates in IRF3 activation.

Go back
802.0, 660.0
25.0, 25.0

p88

p88

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e109 MO000000065 MO000016899

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c248 : 1
stoichiometry:c249 : 1
stoichiometry:c250 : 1
stoichiometry:c247 : 1

m977*m113*m88*m1814*0.1

nodelay

--

true

0

false

PMID: 15950447, 15208624 Retinoic acid-inducible gene I has recently been identified as an intracellular sensor for dsRNA, and is composed of the RNA helicase domain, which binds dsRNA, and the caspase recruitment domain (CARD), which culminates in IRF3 activation. PMID: 15950447, 15549108 Fas-associated death domain (FADD) and RIP1 have been demonstrated to be involved in this pathway.

Go back
873.0, 1675.0
27.0, 27.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000020434 MO000042032

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c256 : 1
stoichiometry:c252 : 1

m4923*m155701*0.1

nodelay

--

true

0

false

PMID: 15950447, 15476921 NOD1 and NOD2 recognize naturally occurring degradation products and minimal motifs of bacterial peptidoglycan.

Go back
344.0, 1010.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e24 MO000042012

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m25*m19828*0.1

nodelay

--

true

0

false

PMID: 15950447 TLR9 also recognizes non-nucleic acids, such as hemozoin.

Go back
1058.0, 1656.0
25.0, 25.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000020461 MO000042032

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c255 : 1
stoichiometry:c254 : 1

m4947*m155701*0.1

nodelay

--

true

0

false

PMID: 15950447, 15476921 NOD1 and NOD2 recognize naturally occurring degradation products and minimal motifs of bacterial peptidoglycan.

Go back
1087.0, 1411.0
25.0, 25.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019479 MO000020434

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c259 : 1
stoichiometry:c261 : 1

m360980*m4923*0.1

nodelay

--

true

0

false

PMID: 15950447, 15476921 NOD1 and NOD2 recognize naturally occurring degradation products and minimal motifs of bacterial peptidoglycan.

Go back
1088.0, 1456.0
23.0, 23.0

p92

p92

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019479 MO000020461

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c260 : 1
stoichiometry:c262 : 1

m360980*m4947*0.1

nodelay

--

true

0

false

PMID: 15950447, 15476921 NOD1 and NOD2 recognize naturally occurring degradation products and minimal motifs of bacterial peptidoglycan.

Go back
431.0, 359.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 90.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1017.0, 801.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
931.0, 1192.1701742519247

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.6325770306054, 1202.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.2728210583712, 983.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.3643173537448, 1097.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.9998469739546, 784.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.0, 1210.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 1238.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 1281.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.3846153846154, 1171.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.0, 136.85994340570036

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.9441005758471, 1181.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
849.0, 1181.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
968.0, 245.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 283.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0, 238.2790621242674

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1040.0, 232.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.0, 226.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.0, 285.86234793301037

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 235.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0, 283.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 130.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.4164522465671, 249.88744809409462

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.0, 311.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.7569037838267, 250.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 238.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
910.9954264316419, 245.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 363.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.5689290811055, 217.84464540552736

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 358.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.0, 437.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 458.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1155.0, 151.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 210.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
826.6487017042326, 225.54879985706305

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.0, 343.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 376.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.5923353935949, 386.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0, 385.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.9958409147176, 418.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.0, 480.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 491.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
834.020613557655, 493.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.0, 170.15541752799933

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 538.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.8649682467477, 218.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
811.1619101498209, 218.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 427.7431017633523

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 499.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
831.9955592558332, 587.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 602.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
830.51964259655, 548.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
721.0, 435.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
869.0, 754.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.0, 163.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
798.9695391434786, 1018.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.0, 1204.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.0, 1217.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.5538553641524, 1129.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
726.9189245967844, 1134.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.9065014939317, 407.3187216341635

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 218.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.1695605842158, 237.34533087770632

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0856580228888, 560.1754418849364

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0, 503.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.76063068841773, 1152.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.8318433579009, 544.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.9999994167314, 503.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 561.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 617.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.0, 875.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.0, 967.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.8599434057004, 868.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.0, 923.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 631.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
765.0, 95.14695530566195

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
210.0, 1153.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.0, 869.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.8160846153542, 907.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
980.0, 116.80672125868864

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
853.0, 1181.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.0, 1326.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.9766904249237, 328.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.8960395148597, 328.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.0, 685.5970433718076

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.0, 673.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.0, 933.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 1191.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.0, 933.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
815.0, 808.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0429828960275, 503.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 779.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.2905467105794, 790.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 933.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.650113557216, 937.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.4042830456932, 503.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.3343588757587, 906.9619305082008

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.050939126483, 866.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.4307351936248, 1261.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 973.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 993.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.7211226860248, 734.338952620092

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.0, 742.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 999.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 1029.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
785.0, 954.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.535242905885, 860.7759056409234

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.0, 913.9785396545255

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.4985898687328, 1041.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.0, 379.3593861171244

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.0, 1267.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.4352642519865, 1089.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 1202.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.4618485406781, 1151.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.0, 1562.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 1377.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1145.0, 589.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1125.0, 609.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.0, 601.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1144.3463717031361, 736.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1095.0, 1037.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 1307.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1143.0, 623.9471859359636

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.4892921906088, 1051.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.9995274520803, 1444.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.0, 1399.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 1445.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.0, 1445.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.0, 1360.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.0, 1417.0

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
437.0, 1081.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.0, 1061.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
229.0, 902.8

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.0, 952.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
983.6932315990238, 875.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0, 965.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0, 969.6686348824677

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
383.0, 1513.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 1443.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.0, 952.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
304.0, 1198.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
66.59490444565779, 52.915859887493525

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 1216.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.9991350883806, 887.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.0, 1249.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 1268.9711254108329

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
86.8792283770074, 223.0

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
375.0, 1485.6954753506957

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
455.0, 1472.0563366312256

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.0, 1299.668280225013

c235

c235

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
445.0, 1262.746869776819

c236

c236

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
445.0, 1220.7851640912004

c237

c237

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
475.0, 450.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.0, 1561.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.0, 894.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.3552049089658, 1491.0

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.9963206039143, 1134.0

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 1421.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 364.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.7611400011626, 421.94028500029066

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.0, 424.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.4100581234954, 604.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 685.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.0, 512.0

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.0, 599.0

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.0, 1043.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.0, 687.9711576880163

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
887.0, 1537.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 1545.46113605976

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.0, 1536.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.0, 1547.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
48.04750052999839, 31.652001695994954

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
35.579864075487535, 15.97966431826626

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 1426.8834522085988

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 1440.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.0, 1433.322338796717

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.93892035882453, 900.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 1478.816734903234

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1112.0, 1424.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1111.0, 1468.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0, 1000.7235286688388

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
188.0, 617.7976219786146

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 683.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 372.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.55360145156624, 564.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.9995660075403, 683.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 688.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.0, 599.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
200.0, 354.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.0899458438937, 370.1877316447983

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 355.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.0, 399.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.0, 396.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 408.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.0, 127.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.17421044987253, 238.34332268254093

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.0, 219.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 219.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 319.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
161.0, 319.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.92737573118032, 337.3024573305795

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
240.0, 288.92515233577853

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
180.8485155621994, 1381.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
162.0, 1383.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.0, 1420.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 147.55086685092814

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 1349.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
119.55512384920269, 271.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
274.5325719930081, 538.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.0, 643.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
269.0, 643.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
197.0, 655.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 759.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.81570304415754, 692.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 540.6499055497528

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 527.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.0, 140.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.0, 494.4127755881572

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
146.06407211482323, 581.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
164.20169760398448, 690.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.0, 799.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.0, 489.85296421844834

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.4977748084605, 492.78986969617137

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 456.90702922488686

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
132.04611981478098, 505.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
145.0, 843.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0, 378.0389749949209

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
372.0, 143.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 372.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 151.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.464060241731, 259.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1045.0, 304.6871067372241

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.0, 303.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1031.0, 359.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.4470545031274, 315.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.0, 359.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.0, 370.15664483774583

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1208.0, 359.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.0, 164.13399526189997

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1216.4, 369.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1210.0, 411.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1217.0402649471412, 422.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1147.9861949854, 472.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.9955592558333, 475.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.0, 333.49063342055234

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1071.0, 496.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1010.0, 497.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1023.0, 532.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.0, 545.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 157.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1023.0, 593.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1030.3342580445078, 604.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.0, 666.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1021.0, 666.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
975.0, 725.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 737.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1073.0, 721.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1065.0, 732.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1039.0, 859.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.0, 871.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back