1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16001129.csml convertedTime:2009.07.01.10:52

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The Toll-like receptors: analysis by forward genetic methods.
Authors Beutler B.
Affiliation The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA,92037, USA. Bruce@scripps.edu
Abstract Many genes, and conceivably most genes, are constitutively expressed yet haveconditional functions. Their products are utilized only under specialcircumstances, and enforce homeostatic regulation. Mutations do not disclose thefunction of such genes unless the proper conditions are applied. The genes thatencode the Toll-like receptors (TLRs) fall into this category. The TLRsrepresent the principal sensors of infection in mammals. Absent infection,mammals have little need for the TLRs; they are essential only when microbesgain access to the interior milieu of the host. The function of the TLRs inmammals was first disclosed by a spontaneous mutation in a locus called Lps,when it was shown by positional cloning to be identical to Tlr4. Random germlinemutagenesis has since permitted an estimate of the total number of proteinsrequired for TLR signaling to the level of tumor necrosis factor (TNF) synthesisand activity, and has also shown that these sensors are extremely broad in theirability to detect microbes. Ultimately, the TLRs are responsible for mostinfection-related phenomena, both good and bad. These include the development offever, shock, and tissue injury, but also the activation of innate and adaptiveeffector mechanisms that lead to the elimination of microbes.
PMID 16001129
Model Abstract

Entity

G010228:IFN-beta MO000000058:NF-kappaB MO000007694:IRF-3 MO000016573:MyD88 MO000016660:IFNbeta MO000016882:LPS MO000018132:CD14 MO000019331:TBK1 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019420:LBP MO000019422:TLR6 MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022131:MD-2 MO000022224:dsRNA MO000022528:TIRAP MO000038315:LPS:LBP:CD14:TLR4:MD-2:TIRAP MO000038321:LPS:LBP:CD14:TLR4:MD-2:MyD88 MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042128:TLR10 e1: e10: e11:IRAK1 e12:IRAK1{active} e13:IRAK-4{active} e14: e15: e16: e17: e18: e19: e2: e20:TLR2:TLR1 e21:TLR2:TLR6 e22:TLR2:TLR10 e23:unmethylated DNA e24:NF-kappaB{active} e25:LPS:LBP:CD14:TLR4:MD-2:MyD88:TIRAP e26:ssRNA e27:TLR7:ssRNA e28:TLR8:ssRNA e29:TLR9:unmethylated DNA e3: e30:TBK1{active} e31:IRF-3{active} e32:protein kinase e33:triacylated lipopeptides e34:TKR2:TLR1:triacylated lipopeptides e35:TLR2:TLR2 e36:diacylated lipopeptides e37:TLR2:TLR2:diacylated lipopeptides e38:lipoteichoic acid e39:TLR2:TLR2:lipoteichoic acid e4: e40:zymosan e41:TLR2:TLR2:zymosan e44:CD36 e45:TLR2:TLR6:CD36 e46:TLR2:TLR6:CD36:diacylated lipopeptides e47:dectin e48:TLR2:TLR6:Dectin e49:TLR2:TLR6:dectin:zymosan e5:TLR4:MD-2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:LBP:CD14:TLR4:MD-2 e60: e61: e62: e63:F protein e64:TLR4:F protein e65:envelope glycoprotein e66:TLR4: envelope glycoprotein e67:TLR2:TLR6:CD36:diacylated lipopeptides:MyD88 e68:TLR2:TLR6:CD36:diacylated lipopeptidesMyD88:TIRAP e69:TLR2:TLR1:triacylated lipopeptides:MyD88 e7: e70:TLR2:TLR1:triacylated lipopeptides:MyD88:TIRAP e71:TLR2:TLR2:diacylated lipopeptides:MyD88 e72:TLR2:TLR2:diacylated lipopeptides:MyD88:TIRAP e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p48 p49 p5 p50 p51 p52 p53 p54 p6 p7 p8 p9
Model Detail
742.0, 926.0
36.0, 36.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p28 p34

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
656.0, 400.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p12 p13 p54

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
614.0, 738.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
598.0, 166.0
27.0, 27.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p42 p46 p50

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1187.0, 951.0
26.0, 26.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28 p34

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
714.0, 6.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
561.0, 65.0
30.0, 30.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p40 p41

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
317.0, 653.0
30.0, 30.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p27 p35

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
248.0, 184.0
31.0, 31.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p40 p41

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1067.0, 455.0
25.0, 25.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
1073.0, 529.0
22.5, 22.5

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9 p10 p30

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
680.0, 608.0
23.0, 23.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
900.0, 12.0
23.0, 23.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
1073.0, 589.0
21.5, 21.5

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
630.0, 22.0
28.0, 28.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
479.0, 63.0
34.0, 34.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p4

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
138.0, 98.0
27.5, 27.5

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
627.0, 551.0
25.0, 25.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
422.0, 522.0
27.0, 27.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p24 p43 p51

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
254.0, 590.0
28.0, 28.0

LPS:LBP:CD14:TLR4:MD-2:TIRAP

--

MO000038315

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p25 p26

true true true true

csml-variable:Double

m16530

10

false

infinite

0

unit false false false
TRANSPATHMO000038315

--

Go back
248.0, 264.0
31.5, 31.5

LPS:LBP:CD14:TLR4:MD-2:MyD88

--

MO000038321

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p6 p7 p14

true true true true

csml-variable:Double

m16536

10

false

infinite

0

unit false false false
TRANSPATHMO000038321

--

Go back
501.0, 357.0
29.5, 29.5

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p16 p25 p45 p49 p53

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
989.0, 517.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p27 p28 p54

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
683.0, 719.0
25.0, 25.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p34

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
595.0, 627.0
26.0, 26.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p21 p23

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
719.0, 583.0
25.0, 25.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p20

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
889.0, 621.0
22.0, 22.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
952.0, 656.0
24.0, 24.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
783.0, 599.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1076.0, 164.0
24.0, 24.0

TLR10

--

MO000042128

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19942

10

false

infinite

0

unit false false false
TRANSPATHMO000042128

--

Go back
231.94686798378027, 47.87317923332674
888.3402996878258, 1351.5443183232128

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
246.88272700748644, 101.10360649690287
850.8182281700697, 1254.0890982294115

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
574.0, 234.5
36.96000000000001, 27.719999999999995

IRAK1

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6 p15 p26 p44 p48 p52

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
534.0, 314.5
36.96000000000001, 27.719999999999995

IRAK1{active}

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6 p15 p26 p44 p48 p52

p12

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
501.0, 461.0
29.5, 29.5

IRAK-4{active}

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p16 p25 p45 p49 p53

p13

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
632.1950131208736, 577.3986992809577
391.90247922923527, 108.42635258675546

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
625.0101343350035, 570.213820495088
406.27223680097393, 122.79611015849434

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
628.9291591272956, 574.1328452873806
398.43418721638966, 114.95806057390938

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
625.0101343350035, 570.213820495088
406.27223680097393, 122.79611015849434

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
630.8886715234421, 576.0923576835263
394.51516242409707, 111.03903578161702

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
625.0101343350035, 570.213820495088
406.27223680097393, 122.79611015849434

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
231.94686798378027, 47.87317923332674
888.3402996878258, 1351.5443183232128

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1070.5, 387.0
26.970004999166807, 33.024495917347124

TLR2:TLR1

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p29

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1066.5, 639.0
27.721213131144804, 33.944342609565076

TLR2:TLR6

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p36 p38

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1075.5, 116.0
25.745209131811354, 31.52474587568739

TLR2:TLR10

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
878.0, 769.5
43.64049482453926, 13.819490027770764

unmethylated DNA

--

e23

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
568.0, 528.0
24.0, 24.0

NF-kappaB{active}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p13 p54

p23

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
246.0, 410.0
36.0, 60.0

LPS:LBP:CD14:TLR4:MD-2:MyD88:TIRAP

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p14

p15 p16

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
834.0, 493.5
43.64049482453926, 13.819490027770764

ssRNA

--

e26

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p17 p18

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
843.5, 583.0
17.85507564130673, 34.5582109186582

TLR7:ssRNA

--

e27

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

p17

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
943.5, 595.0
17.85507564130673, 34.5582109186582

TLR8:ssRNA

--

e28

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

p18

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
858.5, 645.0
19.894102170576634, 38.50471387853542

TLR9:unmethylated DNA

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
249.71367397753676, 66.48949215788895
852.8066877003134, 1314.3116924740907

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
437.0, 773.0
30.0, 30.0

TBK1{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p27 p35

p22

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
649.0, 813.0
30.0, 30.0

IRF-3{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
439.0, 660.0
17.14686623012161, 39.56969130028063

protein kinase

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23 p54

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1253.0, 291.0
45.87047939444911, 25.993271656854503

triacylated lipopeptides

--

e33

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p29

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1073.5, 324.0
20.95439596579697, 40.55689541767156

TKR2:TLR1:triacylated lipopeptides

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p46

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1070.5, 883.0
27.410931511414766, 33.56440593234461

TLR2:TLR2

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31 p32 p33

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1231.0, 864.0
42.287636669470146, 23.96299411269975

diacylated lipopeptides

--

e36

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p31 p37

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1072.5, 958.0
22.78951984213988, 44.10874808156107

TLR2:TLR2:diacylated lipopeptides

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p50

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1228.0, 1100.0
40.824222035323785, 23.13372582001682

lipoteichoic acid

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p32

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1076.5, 1033.0
23.448805086603816, 45.38478403858803

TLR2:TLR2:lipoteichoic acid

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
282.5822650659866, 99.06803977587276
787.069505523414, 1249.1545972381223

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1255.0, 1182.0
50.4121110176619, 28.566862910008403

zymosan

--

e40

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p33 p39

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1076.5, 1105.0
23.64591098443324, 45.766279324709494

TLR2:TLR2:zymosan

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1074.5, 716.0
19.71000201247736, 31.96216542563897

CD36

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1069.5, 759.0
29.995044962378415, 41.85355111029546

TLR2:TLR6:CD36

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

p37

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1077.5, 815.0
21.301030475772855, 41.2278009208507

TLR2:TLR6:CD36:diacylated lipopeptides

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

p42

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1078.5, 1180.0
19.911048500704364, 32.28818675789897

dectin

--

e47

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p38

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1070.5, 1230.0
27.611855386309415, 38.528170306478266

TLR2:TLR6:Dectin

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

p39

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1073.5, 1296.0
20.505810129357595, 39.688664766498576

TLR2:TLR6:dectin:zymosan

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
264.5, 103.0
22.001096250822187, 42.5827669370752

TLR4:MD-2

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p4

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
514.791223226865, 854.4374511171724
482.51161168449977, 458.5078284092547

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
566.9060714162522, 865.3034200849352
282.1390057149592, 444.38541069644407

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
521.0809462842049, 860.5571654593906
469.9321655698205, 446.26839972481855

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
521.9794781495391, 861.498659973578
468.1351018391515, 444.38541069644407

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
514.791223226865, 854.4374511171724
482.51161168449977, 458.5078284092547

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
514.791223226865, 854.4374511171724
482.51161168449977, 458.5078284092547

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
521.9794781495391, 861.498659973578
468.1351018391515, 444.38541069644407

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
867.0157144378966, 1042.7363539546486
30.144674336031457, 28.59366026115618

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
787.9449102884807, 1174.5455859408826
85.3605272067551, 80.96852822011485

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
514.791223226865, 854.4374511171724
482.51161168449977, 458.5078284092547

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
367.0, 59.0
25.500000000000004, 42.500000000000014

LPS:LBP:CD14:TLR4:MD-2

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5 p24 p27 p35 p54

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
628.5164951949338, 1058.1945413808673
15.280433765708368, 7.7090272583075805

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
628.0062382589822, 1035.2043978411489
52.30133593502273, 98.64375542042497

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
649.9472865048945, 1099.3629379519948
8.164110975223053, 8.554472014779396

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
177.0, 656.5
37.830549406319165, 23.328838800563492

F protein

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
255.5, 699.0
25.909230431922822, 50.146897610173205

TLR4:F protein

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p40

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
160.0, 825.0
16.502338634237603, 38.0823199251637

envelope glycoprotein

--

e65

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
251.5, 796.0
24.713001534751154, 47.831615873711904

TLR4: envelope glycoprotein

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1071.0, 202.0
26.647058823529413, 44.41176470588235

TLR2:TLR6:CD36:diacylated lipopeptides:MyD88

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p43

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1075.0, 271.0
25.32352941176471, 42.20588235294119

TLR2:TLR6:CD36:diacylated lipopeptidesMyD88:TIRAP

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44 p45

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
871.0, 51.0
25.588235294117652, 42.64705882352942

TLR2:TLR1:triacylated lipopeptides:MyD88

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p46

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
229.28450334618836, 239.81793525462382
781.2492194713733, 1159.940841924082

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1071.0, 59.0
25.588235294117652, 42.64705882352942

TLR2:TLR1:triacylated lipopeptides:MyD88:TIRAP

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p48 p49

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
255.0, 926.0
26.64705882352941, 44.41176470588236

TLR2:TLR2:diacylated lipopeptides:MyD88

--

e71

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p50

p51

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
255.0, 1026.0
26.64705882352941, 44.41176470588236

TLR2:TLR2:diacylated lipopeptides:MyD88:TIRAP

--

e72

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p51

p52 p53

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
231.1570427512271, 216.4383218479608
777.7190663681735, 1183.242261744647

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
249.9258380314404, 123.9558438952898
811.6307912579468, 1224.2311689125977

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
155.0, 35.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022131 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6438*m3961*0.1

nodelay

--

true

0

false

PMID: 16001129, 12055629, 10359581 Where TLR4 is concerned, a small protein known as MD-2 is tightly bound to the ectodomain of the receptor and is required for LPS sensing to occur.

Go back
1192.0, 100.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000042128

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m3964*m19942*0.1

nodelay

--

true

0

false

PMID: 16001129 By inference, TLR10 (the next most closely related TLR of the clade) may also associate with TLR2

Go back
689.0, 457.0
21.0, 21.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 16001129 These latter TLRs recognize nucleic acids (TLR3 senses dsRNA; TLR7 and TLR8, depending upon species, sense ssRNA; and TLR9 senses unmethylated DNA).

Go back
656.0, 316.0
23.5, 23.5

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e12 MO000000058

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m12*m24*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

Go back
572.0, 416.0
23.5, 23.5

p12

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 MO000000058

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m13*m24*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

Go back
367.0, 459.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000038321 MO000022528

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m16536*m6810*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88, the first adapter protein identified, can signal by itself or in conjuction with Mal, also known as Tirap.

Go back
443.0, 279.0
26.0, 26.0

p6

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m26*m11*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

Go back
371.0, 391.0
26.0, 26.0

p6

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000039077

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m26*m17258*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

Go back
785.0, 521.0
21.0, 21.0

p11

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m19940*m27*0.1

nodelay

--

true

0

false

PMID: 16001129 These latter TLRs recognize nucleic acids (TLR3 senses dsRNA; TLR7 and TLR8, depending upon species, sense ssRNA; and TLR9 senses unmethylated DNA).

Go back
909.0, 537.0
21.0, 21.0

p11

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m19823*m27*0.1

nodelay

--

true

0

false

PMID: 16001129 These latter TLRs recognize nucleic acids (TLR3 senses dsRNA; TLR7 and TLR8, depending upon species, sense ssRNA; and TLR9 senses unmethylated DNA).

Go back
941.0, 721.0
21.0, 21.0

p11

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e23

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m19828*m23*0.1

nodelay

--

true

0

false

PMID: 16001129 These latter TLRs recognize nucleic acids (TLR3 senses dsRNA; TLR7 and TLR8, depending upon species, sense ssRNA; and TLR9 senses unmethylated DNA).

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792.0, 4.0
24.0, 24.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019420

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m3985*0.1

nodelay

--

true

0

false

PMID: 16001129 It was inferred that LPS was conveyed to the cell surface by LBP, which transferred it to CD14: presumably a part of the LPS receptor.

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752.0, 484.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 16001129, 12872135, 12855817 TRIF alone signals from TLR3

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558.0, 730.0
27.0, 27.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041437 MO000019331

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m19305*m3902*0.1

nodelay

--

true

0

false

PMID: 16001129 the TRIF/TRAM pathway leads to TBK-1 activation and to IRF-3 activation.

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539.0, 803.0
26.0, 26.0

p21

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000007694

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m31*m977*0.1

nodelay

--

true

0

false

PMID: 16001129 the TRIF/TRAM pathway leads to TBK-1 activation and to IRF-3 activation.

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494.0, 550.0
27.0, 27.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041437 e24 e32

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m19305*m25*m33*0.1

nodelay

--

true

0

false

PMID: 16001129, 15895089 The TRIF pathway is also capable of activating NF-KappaB, however, and requires a separate protein kinase

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320.0, 512.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000022528

MO000038315

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m6*m6810*0.1

nodelay

--

true

0

false

PMID: 16001129, 12893815, 15241424 As already mentioned, it (TLR4) can signal via MyD88 and Mal alone, or via MyD88, Mal, TRIF, and TRAM

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339.0, 559.0
26.0, 26.0

p6

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000038315 MO000039077

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m16530*m17258*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

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331.0, 267.0
26.0, 26.0

p6

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000038315 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m16530*m11*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

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758.0, 314.0
27.0, 27.0

p21

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 MO000041125 MO000019331

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m6*m18998*m3902*0.1

nodelay

--

true

0

false

PMID: 16001129 the TRIF/TRAM pathway leads to TBK-1 activation and to IRF-3 activation. PMID: 16001129, 12872135, 14556004 TRIF and TRAM, the fourth adapter, signal from TLR4

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975.0, 835.0
25.0, 25.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 MO000041125

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c88 : 1
stoichiometry:c86 : 1

m93217*m18998*0.1

nodelay

--

true

0

false

PMID: 16001129 TRIF and TRAM, two adapters that are crucial for induction of interferon-beta synthesis and for adjuvant effects.

Go back
1195.0, 339.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m20*m34*0.1

nodelay

--

true

0

false

PMID: 16001129, 15690042, 12719479 The story is similarly strange for TLR2, which acts as a heteromer with TLR1 to detect triacylated lipopeptides, and as a heteromer with TLR2 to detect diacylated lipopeptides, lipoteichoic acid, zymosan, and other rather unrelated molecules.

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556.0, 8.0
24.0, 24.0

p2

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018132 MO000021928

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m2828*m6254*0.1

nodelay

--

true

0

false

PMID: 16001129 It was inferred that LPS was conveyed to the cell surface by LBP, which transferred it to CD14: presumably a part of the LPS receptor.

Go back
1180.0, 748.0
23.0, 23.0

p30

p30

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

MO000019397

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m3964*0.1

nodelay

--

true

0

false

PMID: 16001129, 15690042, 12719479 The story is similarly strange for TLR2, which acts as a heteromer with TLR1 to detect triacylated lipopeptides, and as a heteromer with TLR2 to detect diacylated lipopeptides, lipoteichoic acid, zymosan, and other rather unrelated molecules.

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1171.0, 899.0
25.0, 25.0

p29

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e35 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m36*m37*0.1

nodelay

--

true

0

false

PMID: 16001129, 15690042, 12719479 The story is similarly strange for TLR2, which acts as a heteromer with TLR1 to detect triacylated lipopeptides, and as a heteromer with TLR2 to detect diacylated lipopeptides, lipoteichoic acid, zymosan, and other rather unrelated molecules.

Go back
1195.0, 1031.0
25.0, 25.0

p29

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e35 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m36*m39*0.1

nodelay

--

true

0

false

PMID: 16001129, 15690042, 12719479 The story is similarly strange for TLR2, which acts as a heteromer with TLR1 to detect triacylated lipopeptides, and as a heteromer with TLR2 to detect diacylated lipopeptides, lipoteichoic acid, zymosan, and other rather unrelated molecules.

Go back
1219.0, 1151.0
25.0, 25.0

p29

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e35 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m36*m41*0.1

nodelay

--

true

0

false

PMID: 16001129, 15690042, 12719479 The story is similarly strange for TLR2, which acts as a heteromer with TLR1 to detect triacylated lipopeptides, and as a heteromer with TLR2 to detect diacylated lipopeptides, lipoteichoic acid, zymosan, and other rather unrelated molecules.

Go back
871.0, 831.0
25.0, 25.0

p28

p34

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000041132 G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c87 : 1
stoichiometry:c103 : 1

m19005*m93217*0.1

nodelay

--

true

0

false

PMID: 16001129 TRIF and TRAM, two adapters that are crucial for induction of interferon-beta synthesis and for adjuvant effects.

Go back
967.0, 363.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 MO000041132 MO000019331

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m6*m19005*m3902*0.1

nodelay

--

true

0

false

PMID: 16001129 But it (TLR4) can also signal via TRAM alone under certain circumstances PMID: 16001129, 12872135, 14556004 TRIF and TRAM, the fourth adapter, signal from TLR4

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1176.0, 672.0
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m21*m45*0.1

nodelay

--

true

0

false

PMID: 16001129, 15690042 In the case of the TLR2/TLR6 heterodimer, it was shown that CD36 is a third important recognition molecule for diacylated lipopeptides

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1208.0, 788.0
23.0, 23.0

p36

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45 e36

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m46*m37*0.1

nodelay

--

true

0

false

PMID: 16001129, 15690042 In the case of the TLR2/TLR6 heterodimer, it was shown that CD36 is a third important recognition molecule for diacylated lipopeptides

Go back
1194.0, 1182.0
20.0, 20.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e47 e21

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c116 : 1
stoichiometry:c118 : 1

m48*m21*0.1

nodelay

--

true

0

false

PMID: 16001129, 12719479 In the case of the TLR2/TLR6 heterodimer, it was shown that CD36 is a third important recognition molecule for diacylated lipopeptides , while dectin-1 is a coreceptor for glucans that form the major part of zymosan

Go back
1178.0, 1238.0
20.0, 20.0

p38

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m41*m49*0.1

nodelay

--

true

0

false

PMID: 16001129, 12719479 In the case of the TLR2/TLR6 heterodimer, it was shown that CD36 is a third important recognition molecule for diacylated lipopeptides , while dectin-1 is a coreceptor for glucans that form the major part of zymosan

Go back
403.0, 7.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021929 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m6255*m5*0.1

nodelay

--

true

0

false

PMID: 16001129 the LPS receptor, TLR4 was responsible for everything that LPS could do, including induction of cytokines, upregulation of costimulatory molecules, and initiation of both innate and adaptive responses.

Go back
127.0, 491.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e63 MO000018132

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m3961*m64*m2828*0.1

nodelay

--

true

0

false

PMID: 16001129, 11602714,14694089, 12730691, 12110201, 11854525 It was also reported that TLR4 senses the F protein of respiratory syncitial virus (RSV)and the envelope glycoprotein of mouse mammary tumor virus (MMTV)

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115.0, 691.0
25.0, 25.0

p40

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e65 MO000019394 MO000018132

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m66*m3961*m2828*0.1

nodelay

--

true

0

false

PMID: 16001129, 11602714,14694089, 12730691, 12110201, 11854525 It was also reported that TLR4 senses the F protein of respiratory syncitial virus (RSV)and the envelope glycoprotein of mouse mammary tumor virus (MMTV)

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823.0, 235.0
25.0, 25.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e46 MO000016573

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m47*m1572*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
855.0, 307.0
25.0, 25.0

p42

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 MO000022528

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m68*m6810*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
709.0, 161.0
23.0, 23.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m69*m11*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
764.0, 368.0
23.0, 23.0

p44

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 MO000039077

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m69*m17258*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
972.0, 452.0
24.0, 24.0

p42

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000016573

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m35*m1572*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
928.0, 132.0
23.0, 23.0

p44

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m71*m11*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
696.0, 304.0
23.0, 23.0

p44

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 MO000039077

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m71*m17258*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
338.0, 174.0
27.0, 27.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000016573

MO000038321

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88, the first adapter protein identified, can signal by itself or in conjuction with Mal, also known as Tirap. MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4

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740.0, 796.0
24.0, 24.0

p42

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000016573

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m38*m1572*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
388.0, 932.0
24.0, 24.0

p42

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 MO000022528

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m72*m6810*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
480.0, 916.0
23.0, 23.0

p44

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m73*m11*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
336.0, 844.0
23.0, 23.0

p44

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000039077 e72

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c163 : 1

m17258*m73*0.1

nodelay

--

true

0

false

PMID: 16001129 MyD88 and Mal are both required for signaling from TLR2-containing complexes and from TLR4.

Go back
766.0, 414.0
27.0, 27.0

p21

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041125 e6 e32 MO000000058

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m18998*m6*m33*m24*0.1

nodelay

--

true

0

false

PMID: 16001129 the TRIF/TRAM pathway leads to TBK-1 activation and to IRF-3 activation. PMID: 16001129, 12872135, 14556004 TRIF and TRAM, the fourth adapter, signal from TLR4 PMID: 16001129, 15895089 The TRIF pathway is also capable of activating NF-KappaB, however, and requires a separate protein kinase

Go back
414.0, 202.0
27.0, 27.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000038321 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m16536*m11*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

Go back
427.0, 347.0
25.0, 25.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000038321 MO000039077

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m16536*m17258*0.1

nodelay

--

true

0

false

PMID: 16001129 The MyD88/Mal pathway leads to IRAK1/IRAK4 activation, and then to NF-KappaB activation

Go back
1171.0, 547.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000019396

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c26 : 1

m3964*m3963*0.1

nodelay

--

true

0

false

PMID: 16001129, 11095740 TLR2 is known to associate with both TLR1 and TLR6

Go back
1179.0, 615.0
25.0, 25.0

p8

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000019422

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c27 : 1

m3964*m3987*0.1

nodelay

--

true

0

false

PMID: 16001129, 11095740 TLR2 is known to associate with both TLR1 and TLR6

Go back
155.0, 67.73659629810118

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.4150626209072, 33.77985058028379

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.0, 917.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1250.6564023547028, 1176.437601569802

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.7572902970137, 1132.9556194026084

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 849.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.2560717419874, 437.368890451637

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
393.0, 91.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
393.0, 86.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 394.25431741962853

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.0, 385.2829174186304

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.3080184481423, 386.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
287.0, 34.76446981786114

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.0, 660.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.0, 692.3636881022716

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1104.8813550550447, 695.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1099.0, 782.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1228.067021373132, 818.3887333080002

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1106.713190674591, 803.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1084.0, 673.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 1192.3330443576974

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.243671487671, 1197.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1204.9758702830839, 1210.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.07841912241383, 32.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.0, 1248.0999921884154

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.6929482290266, 1254.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.031151621192, 215.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.57811038243443, 523.5731992484011

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.74043921950434, 95.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
147.0, 516.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
133.2535176342803, 723.6760444417673

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.0774595057484, 215.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
141.66639212381415, 95.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
140.0, 714.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.04123408984816, 102.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.1529531747724, 267.3524748403305

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.0, 184.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.0, 225.78542475127156

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.3089135241743, 230.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.0, 330.5777087639997

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.0, 294.97724161074575

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.6113649773038, 179.46315309761144

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.0, 184.02219006453856

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.88001485388, 184.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.7012075212311, 296.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
372.99528866109273, 180.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 372.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.4945915813553, 384.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.1530859662622, 357.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.0, 190.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.9708454383151, 101.75343590018468

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.3180170288771, 86.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.0, 150.27435418143313

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.2307273306102, 150.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.56489087072885, 201.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.7753214928049, 88.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.0, 322.23463632664107

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.1366149612193, 326.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.1041229133046, 817.6785102463714

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.0, 193.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.68262491431636, 811.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 944.301672079202

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
401.7074008596201, 549.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.2699670121001, 953.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 937.8033927873888

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 223.94238764880646

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.16186132001656, 262.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.0, 349.95946949670076

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.6288062507245, 387.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 498.3096382317323

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
277.0, 874.3887333080002

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 443.83284100938965

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 414.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.9875679303642, 436.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.85138296980375, 220.53485682116465

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 228.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 287.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
180.2596089499316, 66.77168602296818

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.89546304620546, 363.28905519121724

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 372.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1096.0, 542.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 479.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 549.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1095.0, 603.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.3394254283967, 426.720817431785

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1101.7664849543942, 631.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1087.0, 130.702133894299

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 122.8201065633589

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
180.0, 56.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.8791385725635, 114.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 485.9884275257881

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 484.76831396103074

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.0, 478.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.0, 328.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 348.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0657561341275, 340.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0, 441.61971776501446

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
603.8446454055273, 414.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.3632612873492, 440.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.0, 17.319744306790973

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.0, 296.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.24549324356997, 490.04026494714117

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.72228835422794, 447.08956037820286

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 306.8814901835989

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
476.6109315218739, 254.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.0, 297.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 410.3224463880644

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.77841899843406, 376.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 411.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 550.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.9796695986458, 17.56997639990328

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.9932582089723, 507.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 542.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 565.7824497174829

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
866.0, 507.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 558.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.5320828753572, 680.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 747.1758195855608

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.2179589656599, 677.0335858293437

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 514.6286613210731

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.9120323748533, 499.1831076448379

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.9363872641302, 17.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.8767073756715, 507.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.6471701423768, 653.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.0, 673.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.5207574722393, 749.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 792.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
571.1972896011401, 765.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.0, 817.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.3792510848185, 578.8275413614842

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.5731992484011, 544.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 428.5268621723705

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.9626509401539, 39.94187025626967

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 584.1057411452476

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.872807424013, 102.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.94858517769745, 525.905535020244

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.9975603804354, 535.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 579.8806047524122

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.071776335029, 387.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.0, 489.0183111620103

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.0, 300.78664912154056

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
364.9342229330722, 250.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 283.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.8446454055273, 24.56892908110547

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.0, 88.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.9987028429207, 344.29297309669477

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
708.0, 739.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.0, 343.88587546636103

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.57341157407876, 341.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.0, 856.1061289595285

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1000.0, 855.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.0, 859.0220196095182

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
989.3884302215919, 547.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1097.0, 360.087614430441

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.1340613839449, 30.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1226.5455335748854, 317.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.9859209902625, 345.4744111479364

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 552.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.9076187020303, 771.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.0, 902.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1203.0308274533256, 887.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.6429245771756, 921.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.0, 916.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1219.069834497013, 1062.8874122257146

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.9560436233712, 1045.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back