1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16332394.csml convertedTime:2009.07.01.10:53

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title ITAM-based signaling beyond the adaptive immune response.
Authors Fodor S, Jakus Z, Mocsai A.
Affiliation Department of Computer Science, Corvinus University, Budapest, Hungary.
Abstract Classical immunoreceptors like lymphocyte antigen receptors and Fc-receptors(FcR) are central players of the adaptive immune response. These receptorsutilize a common signal transduction mechanism, which relies on immunoreceptortyrosine-based activation motifs (ITAMs) present in the receptor complex. Uponligand binding to the receptors, tyrosines within the ITAM sequence arephosphorylated by Src-family kinases, leading to an SH2-domain mediatedrecruitment and activation of the Syk or the related ZAP-70 tyrosine kinase.These kinases then initiate further downstream signaling events. Here we reviewrecent evidence indicating that components of this ITAM-based signalingmachinery are also present in a number of non-lymphoid or even non-immune celltypes and they participate in diverse biological functions beyond the adaptiveimmune response, including innate immune mechanisms, platelet activation, boneresorption or tumor development. These results suggest that the ITAM-basedsignaling paradigm has much wider implications than previously anticipated.
PMID 16332394
Model Abstract

Entity

MO000000143:Fyn MO000000144:Lyn MO000008301:Syk MO000017426:fibrinogen MO000017432:IAP MO000017705:FcepsilonRI MO000017802:CD3zeta MO000017934:Kir MO000018210:FcRgamma MO000018212:FcgammaRIII MO000018217:IgE MO000023102:moesin MO000060587:MICB MO000062251:ULBP1 MO000062732:NKp46 MO000063027:NKp30 MO000063203:OSCAR MO000065624:NKp44 MO000065959:MICA MO000066771:TYROBP MO000066832:ULBP2 MO000066849:EAST MO000069041:LILRA2 MO000070820:TREM2 MO000070851:CD99 MO000083632:collagen e1: e10:FcRgamma:CD3zeta e100:ILT-1 e101:ILT-1:TYROBP e102:LILRA2:TYROBP e103:dectin-1 e104:Beta-glucan e105:Dectin-1:Beta-Glucan e106:FcepsilonRI:IgE e107:FcepsilonRI:IgE:FcRgamma e108:CD200R3 e109:CD200R3:TYROBP e11:Collagen:GpVI:FcRgamma e110:PGSL-1 e111:Syk:moesin e112:Tamalin:receptor e113:Src e114:Tamalin{p}:receptor e115:Tamalin{p}:receptor:Syk e116:mRNA e117:STAM1 e118:Jak kinases e119:STAM1:Jak kinases e12:Collagen:GpVI:FcRgamma{p} e120:EAST:Jak kinases e121:EAST{p}:Jak kinases e122:STAM1{p}:Jak kinases e13:Syk{active} e14:AlphaIIb/beta3 e15:fibrinogen:AlphaIIb/beta3 e16:Syk{p} e17:fibrinogen:AlphaIIb/beta3:Syk e18:TYROBP:TREM2 e19:Fcgamma:TREM2 e2: e20:TYROBP:OSCAR e21:FcRgamma:OSCAR e22:CD94:NKG2C e23:CD94:NKG2C:TYROBP e24:NKG2D e25:NKG2D:TYROBP e26:Kir:TYROBP e27:Ly49H e28:NKp44:TYROBP e29:Ly49D e3: e30:Ly49D:TYROBP e31:Ly49H:TYROBP e32:Ly49L e33:Ly49L:TYROBP e34:Ly49P e35:Ly49P:TYROBP e36:PIRL-beta e37:PIRL-beta:TYRPOBP e38:CD94:NKG2E e39:CD94:NKG2E:TYROBP e4: e40:CD94:NKG2H e41:CD94:NKG2H:TYROBP e42:m157 e43:Ly49H:TYROBP:m157 e44:Hemagglutinin e45:NKp44:TYROBP:Hemagglutinin e46:Rae-1 e47:NKG2D:TYROBP:Rae-1 e48:H-60 e49:NKG2D:TYROBP:H-60 e5:GpVI e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:GpVI:FcRgamma e60: e61: e62: e63:NKG2D:TYROBP:MICA e64:NKG2D:TYROBP:MICB e65:NKG2D:TYROBP:ULBP1 e66:NKG2D:TYROBP:ULBP2 e67:NKR-PIC e68:FCgammaRIII:FcRgamma e69:FcgammaRIII:CDzeta e7: e70:FcRgamma: NKR-PIC e71: CDzeta:NKp30 e72:FcRgamma:NKp46 e73:Cd3zeta:NKp46 e74:TREM-1 e75:TREM-1:TYROBP e76:SIRPbeta1 e77:SIRPbeta1:IAP e78:PIRLbeta e79:PIRLbeta:CD99 e8: e80:CEACAM3 e81:Opa protein e82:CEACAM3:Opa protein e83:Beta2integrins e84:Syk{active}:Beta2integrins e85:MDL-1 e86:MDL-1:TYROBP e87:TREM-3 e88:TREM-3:TYROBP e89:CD200RL e9:CEACAM3{p}:Opa protein e90:CD200RL:TYROBP e91:SIRPbeta1:TYROBP e92:IREM-2 e93:IREM-2:TYROBP e94:NKG2D-S e95:NKG2D-S:TYROBP e96:MAIR-II e97:MAIR-II:TYROBP e98:PIR-A e99:PIR-A:TYROBP

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p8 p9
Model Detail
641.0, 233.0
22.0, 22.0

Fyn

--

MO000000143

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p66

true true true true

csml-variable:Double

m127

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000143

--

Go back
857.0, 293.0
21.0, 21.0

Lyn

--

MO000000144

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m128

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
772.0, 312.0
24.0, 24.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p7 p8 p13 p14 p15 p16 p48 p63 p67

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
1224.0, 264.0
24.0, 24.0

fibrinogen

--

MO000017426

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m2254

10

false

infinite

0

unit false false false
TRANSPATHMO000017426

--

Go back
189.0, 1217.0
22.0, 22.0

IAP

--

MO000017432

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m2258

10

false

infinite

0

unit false false false
InterProIPR006704
TRANSPATHMO000017432

--

Go back
1032.0, 1512.0
24.0, 24.0

FcepsilonRI

--

MO000017705

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m2465

10

false

infinite

0

unit false false false
TRANSPATHMO000017705

--

Go back
1147.0, 179.0
18.0, 18.0

CD3zeta

--

MO000017802

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p38 p41 p42

true true true true

csml-variable:Double

m2557

10

false

infinite

0

unit false false false
InterProIPR003110
TRANSPATHMO000017802

--

Go back
194.0, 658.0
19.5, 19.5

Kir

--

MO000017934

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m2671

10

false

infinite

0

unit false false false
TRANSPATHMO000017934

--

Go back
672.0, 104.0
23.0, 23.0

FcRgamma

--

MO000018210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p10 p12 p36 p37 p40 p42 p57 p58 p61

true true true true

csml-variable:Double

m2891

10

false

infinite

0

unit false false false
TRANSPATHMO000018210

--

Go back
1145.0, 969.0
22.0, 22.0

FcgammaRIII

--

MO000018212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p39

true true true true

csml-variable:Double

m2893

10

false

infinite

0

unit false false false
TRANSPATHMO000018212

--

Go back
1005.0, 1585.0
22.0, 22.0

IgE

--

MO000018217

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m2898

10

false

infinite

0

unit false false false
TRANSPATHMO000018217

--

Go back
843.0, 399.0
26.0, 26.0

moesin

--

MO000023102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m6914

10

false

infinite

0

unit false false false
InterProIPR008954
TRANSPATHMO000023102

--

Go back
45.0, 365.0
22.0, 22.0

MICB

--

MO000060587

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m35488

10

false

infinite

0

unit false false false
TRANSPATHMO000060587

--

Go back
47.0, 287.0
18.0, 18.0

ULBP1

--

MO000062251

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m37142

10

false

infinite

0

unit false false false
TRANSPATHMO000062251

--

Go back
1142.0, 1058.0
20.0, 20.0

NKp46

--

MO000062732

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p41

true true true true

csml-variable:Double

m37618

10

false

infinite

0

unit false false false
TRANSPATHMO000062732

--

Go back
1147.0, 355.0
18.0, 18.0

NKp30

--

MO000063027

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m37910

10

false

infinite

0

unit false false false
TRANSPATHMO000063027

--

Go back
193.0, 241.0
22.5, 22.5

OSCAR

--

MO000063203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m38083

10

false

infinite

0

unit false false false
TRANSPATHMO000063203

--

Go back
1143.0, 491.0
25.5, 25.5

NKp44

--

MO000065624

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m40489

10

false

infinite

0

unit false false false
TRANSPATHMO000065624

--

Go back
54.0, 454.0
20.0, 20.0

MICA

--

MO000065959

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m40822

10

false

infinite

0

unit false false false
TRANSPATHMO000065959

--

Go back
254.0, 110.0
20.0, 20.0

TYROBP

--

MO000066771

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p11 p17 p18 p19 p20 p21 p22 p23 p24 p25 p26 p27 p43 p49 p50 p51 p52 p53 p54 p55 p56 p62

true true true true

csml-variable:Double

m41628

10

false

infinite

0

unit false false false
TRANSPATHMO000066771

--

Go back
59.0, 239.0
18.0, 18.0

ULBP2

--

MO000066832

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m41689

10

false

infinite

0

unit false false false
TRANSPATHMO000066832

--

Go back
809.0, 569.0
22.0, 22.0

EAST

--

MO000066849

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m41706

10

false

infinite

0

unit false false false
TRANSPATHMO000066849

--

Go back
888.0, 1520.0
23.0, 23.0

LILRA2

--

MO000069041

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m43885

10

false

infinite

0

unit false false false
TRANSPATHMO000069041

--

Go back
189.0, 173.0
21.0, 21.0

TREM2

--

MO000070820

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10

true true true true

csml-variable:Double

m45659

10

false

infinite

0

unit false false false
TRANSPATHMO000070820

--

Go back
210.0, 1498.0
20.0, 20.0

CD99

--

MO000070851

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m45690

10

false

infinite

0

unit false false false
TRANSPATHMO000070851

--

Go back
789.0, 13.0
21.0, 21.0

collagen

--

MO000083632

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m57739

10

false

infinite

0

unit false false false
TRANSPATHMO000083632

--

Go back
170.75, 75.74695562350587
1025.6740058126575, 1489.2786564399776

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
193.5, 443.0
21.180803199466766, 25.93567738710216

FcRgamma:CD3zeta

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p42

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
795.5, 1504.0
25.428822495606326, 39.121265377855885

ILT-1

--

e100

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p57

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1144.5, 1347.0
22.021829695050823, 26.96550574904182

ILT-1:TYROBP

--

e101

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p57

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
848.5, 1514.0
22.55257457090485, 27.61539743376104

LILRA2:TYROBP

--

e102

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p58

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
929.5, 1512.0
20.973637961335676, 32.26713532513181

dectin-1

--

e103

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p59

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
848.0, 1580.5
24.323374340949034, 15.810193321616875

Beta-glucan

--

e104

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p59

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
977.5, 1504.0
20.55338741504056, 39.78074983556238

Dectin-1:Beta-Glucan

--

e105

cso30:c:Complex

cso30:i:CC_Extracellular

--

p59

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1102.5, 1513.0
19.343565007673753, 37.43915807936856

FcepsilonRI:IgE

--

e106

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p60

p61

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1145.5, 1133.0
21.48027160946963, 29.972472013213437

FcepsilonRI:IgE:FcRgamma

--

e107

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p61

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1140.5, 1486.0
23.57820738137083, 36.27416520210896

CD200R3

--

e108

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p62

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1141.5, 1263.0
20.633727712047982, 25.26578903516081

CD200R3:TYROBP

--

e109

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p62

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
793.5, 105.0
21.740686364470548, 30.335841438796106

Collagen:GpVI:FcRgamma

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3 p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
947.0, 112.5
25.007043670758705, 15.421010263634534

PGSL-1

--

e110

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p63

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
762.5, 501.0
18.331111481419764, 22.44625895684053

Syk:moesin

--

e111

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p64

p68

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
998.5, 98.0
18.670686253014686, 36.13681210260907

Tamalin:receptor

--

e112

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p65 p66

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
952.5, 280.0
14.661501308110282, 23.775407526665315

Src

--

e113

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p65

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
1053.5, 92.0
21.178688884016662, 40.991010743258045

Tamalin{p}:receptor

--

e114

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p65 p66

p67

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1112.5, 80.0
22.979629289777943, 32.06459900899248

Tamalin{p}:receptor:Syk

--

e115

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p67

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
518.0, 1036.0
44.688581314878896, 23.833910034602077

mRNA

--

e116

cso30:c:mRNA

cso30:i:CC_Cell_WithoutCellWall_

--

p68

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
817.0, 506.5
25.759999999999987, 19.319999999999993

STAM1

--

e117

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p69

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
953.0, 488.0
13.583723105706262, 31.347053320860606

Jak kinases

--

e118

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p69 p70

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
962.5, 588.0
19.180303282786188, 23.486085652391253

STAM1:Jak kinases

--

e119

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p69

p72

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
888.5, 84.0
23.47678473114333, 32.75830427601395

Collagen:GpVI:FcRgamma{p}

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3 p4

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
795.5, 653.0
17.898350274954176, 21.916347275454093

EAST:Jak kinases

--

e120

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p70

p71

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
865.5, 727.0
20.53574404265955, 25.145809031828026

EAST{p}:Jak kinases

--

e121

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p71

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
985.5, 707.0
20.53574404265955, 25.145809031828026

STAM1{p}:Jak kinases

--

e122

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p72

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
740.0, 252.0
24.0, 24.0

Syk{active}

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5 p13 p14 p15 p16 p63

p64

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
1144.5, 258.0
23.62390158172232, 36.344463971880494

AlphaIIb/beta3

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1150.5, 310.0
18.20171015128261, 35.22911642183732

fibrinogen:AlphaIIb/beta3

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7 p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
716.0, 356.0
24.0, 24.0

Syk{p}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
1144.5, 416.0
23.42154523765829, 32.68122591301157

fibrinogen:AlphaIIb/beta3:Syk

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
186.5, 112.0
18.992501249791697, 23.25612397933677

TYROBP:TREM2

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p15

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
375.5, 101.0
17.432927845359107, 21.346442259623394

Fcgamma:TREM2

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p16

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
170.75, 75.74695562350587
1025.6740058126575, 1489.2786564399776

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
197.5, 207.0
21.04199300116647, 25.765705715714052

TYROBP:OSCAR

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p14

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
193.5, 315.0
20.87868688551908, 25.565739043492744

FcRgamma:OSCAR

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
189.5, 399.0
21.001166472254624, 25.71571404765872

CD94:NKG2C

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
192.5, 352.0
22.900715727656454, 31.954487061846216

CD94:NKG2C:TYROBP

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
193.5, 484.0
20.448154657293493, 31.458699472759225

NKG2D

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
194.5, 532.0
19.2619563406099, 23.586068988501914

NKG2D:TYROBP

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p30 p31 p32 p33 p34 p35

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
192.5, 702.0
22.364772537910344, 27.38543576070655

Kir:TYROBP

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
192.5, 747.0
22.001757469244293, 33.84885764499121

Ly49H

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1145.5, 539.0
20.641893017830363, 25.275787368771873

NKp44:TYROBP

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p29

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1144.5, 607.0
22.001757469244293, 33.84885764499121

Ly49D

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
191.26348011625308, 96.26043573975906
984.6470455801497, 1448.2516962074722

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1146.5, 576.0
18.902682886185634, 23.146142309615065

Ly49D:TYROBP

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
198.5, 796.0
18.902682886185634, 23.146142309615065

Ly49H:TYROBP

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p28

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1144.5, 695.0
22.001757469244293, 33.84885764499121

Ly49L

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1146.5, 740.0
18.902682886185634, 23.146142309615065

Ly49L:TYROBP

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
198.8585237258348, 833.1669595782074
18.643233743409493, 28.68189806678383

Ly49P

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
194.5, 880.0
18.902682886185634, 23.146142309615065

Ly49P:TYROBP

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1140.5, 779.0
22.6414762741652, 34.83304042179262

PIRL-beta

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1142.5, 836.0
19.88251958006999, 24.34594234294285

PIRL-beta:TYRPOBP

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
192.5, 914.0
22.430094984169312, 27.465422429595076

CD94:NKG2E

--

e38

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p26

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
193.5, 961.0
21.47238025325748, 29.961460818498818

CD94:NKG2E:TYROBP

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
229.21341833132158, 132.15902594320204
908.7471691500134, 1376.4545158005853

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1144.5, 882.0
22.430094984169312, 27.465422429595076

CD94:NKG2H

--

e40

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p27

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1149.5, 921.0
21.33822719765094, 29.774270508350153

CD94:NKG2H:TYROBP

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
63.5, 747.0
16.5826121956128, 26.890722479372105

m157

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
193.5, 1010.0
20.091392916131408, 28.034501743439176

Ly49H:TYROBP:m157

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1260.5, 404.0
15.063594284564303, 24.42745019118535

Hemagglutinin

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p29

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1144.5, 379.0
23.745090842356397, 33.132684896311254

NKp44:TYROBP:Hemagglutinin

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
79.5, 659.0
16.336888710002018, 26.492251962165426

Rae-1

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
192.5, 560.0
22.955955221141497, 32.03156542484861

NKG2D:TYROBP:Rae-1

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
68.5, 504.0
15.197625276715637, 24.644797746025358

H-60

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
192.5, 608.0
22.955955221141497, 32.03156542484861

NKG2D:TYROBP:H-60

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
611.5, 97.0
24.51493848857645, 37.715289982425304

GpVI

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
409.0, 898.0
261.18792741913956, 236.86875354398714

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
437.21024169517705, 903.613445105989
152.72441193595876, 229.57300138144126

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
412.4046843425214, 901.1614926037696
254.378558734097, 230.54576833644728

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
412.89106782002443, 901.6478760812728
253.40579177909075, 229.57300138144126

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
409.0, 898.0
261.18792741913956, 236.86875354398714

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
409.0, 898.0
261.18792741913956, 236.86875354398714

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
412.89106782002443, 901.6478760812728
253.40579177909075, 229.57300138144126

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
599.6623231811968, 995.2766955006109
16.317586607016594, 14.771709981088724

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
556.8605771609282, 1063.3703823510382
46.206430362790044, 41.82897906526262

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
409.0, 898.0
261.18792741913956, 236.86875354398714

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
725.5, 108.0
20.062156307282113, 24.565905682386273

GpVI:FcRgamma

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
470.5605248893786, 1003.2625168123243
8.271437886018058, 3.9825441673420308

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
470.28431816538466, 991.3856276805863
28.31118920937583, 50.96014057687649

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
482.16120729712316, 1024.5304345598556
4.4193075839025635, 4.419307583902565

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
190.5, 142.0
19.759955955221145, 27.57203156542485

NKG2D:TYROBP:MICA

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
306.5, 106.0
19.759955955221145, 27.57203156542485

NKG2D:TYROBP:MICB

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
194.5, 274.0
19.759955955221145, 27.57203156542485

NKG2D:TYROBP:ULBP1

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
426.5, 86.0
19.759955955221145, 27.57203156542485

NKG2D:TYROBP:ULBP2

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
851.5, 101.0
24.355008787346215, 37.46924428822495

NKR-PIC

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1149.5, 655.0
20.731711381436433, 25.385769038493592

FCgammaRIII:FcRgamma

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1146.5, 460.0
19.13131144809198, 23.42609565072488

FcgammaRIII:CDzeta

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
172.0, 112.04640624363392
824.8706727569863, 1168.8204366741058

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
481.5, 103.0
21.972837860356602, 26.905515747375436

FcRgamma: NKR-PIC

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1150.5, 217.0
18.04532577903683, 22.096317280453256

CDzeta:NKp30

--

e71

cso30:c:Complex

cso30:i:CC_Extracellular

--

p38

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1145.5, 1015.0
20.625562406265622, 25.255790701549735

FcRgamma:NKp46

--

e72

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1147.5, 1094.0
16.75520746542243, 20.516580569905017

Cd3zeta:NKp46

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
193.5, 1088.0
21.384885764499128, 32.89982425307557

TREM-1

--

e74

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p43

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
193.5, 1131.0
20.699050158306953, 25.345775704049327

TREM-1:TYROBP

--

e75

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p43

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
196.5, 1166.0
23.715289982425308, 36.48506151142355

SIRPbeta1

--

e76

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p44 p52

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
194.5, 1257.0
19.601841701381275, 37.939048454286336

SIRPbeta1:IAP

--

e77

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p44

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
201.5, 1439.0
21.476274165202106, 33.04042179261862

PIRLbeta

--

e78

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p45

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
246.5, 1521.0
19.778557333918, 38.281078710809034

PIRLbeta:CD99

--

e79

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p45

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
188.0, 105.0
968.1112272158709, 1405.6975019174442

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
289.5, 1512.0
21.40773286467487, 32.93497363796133

CEACAM3

--

e80

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p46

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
312.0, 1588.5
24.367075870396455, 15.026363453411152

Opa protein

--

e81

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p46

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
350.5, 1493.0
19.663012497259373, 38.057443543082655

CEACAM3:Opa protein

--

e82

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p46

p47

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
565.5, 100.0
21.270650263620386, 32.72407732864676

Beta2integrins

--

e83

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p48

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
526.5, 90.0
18.160929620697218, 35.15018636263977

Syk{active}:Beta2integrins

--

e84

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p48

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
465.5, 1511.0
21.476274165202113, 33.04042179261862

MDL-1

--

e85

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p49

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
534.5, 1500.0
18.992501249791697, 23.256123979336778

MDL-1:TYROBP

--

e86

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p49

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
584.5, 1511.0
22.298769771528995, 34.30579964850615

TREM-3

--

e87

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p50

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
193.5, 1387.0
20.429595067488755, 25.01583069488419

TREM-3:TYROBP

--

e88

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p50

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
644.5, 1510.0
23.281195079086118, 35.81722319859402

CD200RL

--

e89

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p51

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
422.5, 1505.0
19.663012497259373, 38.057443543082655

CEACAM3{p}:Opa protein

--

e9

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p47

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
190.5, 1052.0
19.564072654557563, 23.956007332111312

CD200RL:TYROBP

--

e90

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p51

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
197.5, 1351.0
20.90318280286619, 25.595734044325937

SIRPbeta1:TYROBP

--

e91

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p52

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1146.5, 1178.0
18.460456942003514, 28.40070298769772

IREM-2

--

e92

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p53

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1146.5, 1220.0
19.106815530744875, 23.396100649891686

IREM-2:TYROBP

--

e93

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p53

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1145.5, 1308.0
20.859402460456945, 32.091388400702996

NKG2D-S

--

e94

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p54

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1145.5, 1391.0
20.723546075654056, 25.375770704882516

NKG2D-S:TYROBP

--

e95

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p54

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
691.5, 1509.0
24.240773286467487, 37.29349736379612

MAIR-II

--

e96

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p55

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
197.5, 1307.0
21.16447258790202, 25.915680719880015

MAIR-II:TYROBP

--

e97

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p55

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
749.5, 1511.0
21.956063268892795, 33.77855887521969

PIR-A

--

e98

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p56

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1144.5, 1438.0
22.372937843692714, 27.39543409431761

PIR-A:TYROBP

--

e99

cso30:c:Complex

cso30:i:CC_Extracellular

--

p56

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
718.0, 10.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000083632 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m57739*m6*0.1

nodelay

--

true

0

false

PMID:16332394,12649139 The major collagen receptor on platelets is GpVI, a transmembrane immunoglobulin-superfamily receptor PMID:16332394,9295288,9280292 GpVI is structurally related to the IgA Fcalpha-receptors and it is associated with the ITAM-bearing FcR gamma-chain

Go back
397.0, 185.0
21.0, 21.0

p9

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018210 MO000070820

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m2891*m45659*0.1

nodelay

--

true

0

false

PMID: 16332394,15085135 Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively

Go back
357.0, 325.0
21.0, 21.0

p9

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063203 MO000066771

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m38083*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,15085135 Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively

Go back
369.0, 273.0
21.0, 21.0

p9

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063203 MO000018210

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m38083*m2891*0.1

nodelay

--

true

0

false

PMID: 16332394,15085135 Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively

Go back
498.0, 374.0
19.0, 19.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e21 MO000008301

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m21*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,15073337 Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts

Go back
494.0, 338.0
19.0, 19.0

p13

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000008301

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m20*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,15073337 Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts

Go back
498.0, 294.0
19.0, 19.0

p13

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18 MO000008301

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m18*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,15073337 Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts

Go back
510.0, 254.0
19.0, 19.0

p13

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 MO000008301

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m19*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,15073337 Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts

Go back
354.0, 402.0
19.0, 19.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000066771

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m22*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-beta

Go back
242.0, 490.0
19.0, 19.0

p17

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000066771

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m24*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â

Go back
390.0, 710.0
19.0, 19.0

p17

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017934 MO000066771

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m2671*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â

Go back
598.0, 14.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000018210

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m2891*0.1

nodelay

--

true

0

false

PMID: 16332394,10506151,9280292,9295288 GpVI is structurally related to the IgA Fcalpha-receptors and it is associated with the ITAM-bearing FcR gamma-chain

Go back
502.0, 566.0
19.0, 19.0

p17

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066771 MO000065624

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m41628*m40489*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â

Go back
574.0, 566.0
19.0, 19.0

p17

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 MO000066771

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m29*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â

Go back
330.0, 774.0
19.0, 19.0

p17

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000066771

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m27*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â

Go back
858.0, 798.0
19.0, 19.0

p17

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 MO000066771

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m32*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â

Go back
302.0, 866.0
19.0, 19.0

p17

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066771 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m41628*m34*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â

Go back
858.0, 822.0
19.0, 19.0

p17

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000066771

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m36*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179 The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-¦Â PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

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253.0, 957.0
21.0, 21.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 MO000066771

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m38*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10601355 Based on sequence homology, the CD94/NKG2C-related CD94/NKG2E complex (and its alternatively spliced NKG2H form) is also likely to associate with DAP12

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769.0, 821.0
21.0, 21.0

p26

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000066771

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m40*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10601355 Based on sequence homology, the CD94/NKG2C-related CD94/NKG2E complex (and its alternatively spliced NKG2H form) is also likely to associate with DAP12

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62.0, 858.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e31 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m31*m42*0.1

nodelay

--

true

0

false

PMID: 16332394,11950999 The murine cytomegalovirus (MCMV) encoded m157 protein is a ligand of the murine Ly49H protein

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1230.0, 334.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e28 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m28*m44*0.1

nodelay

--

true

0

false

PMID: 16332394,11536166 NKp44 recognizes viral hemagglutinin on influenza or Sendai virus-infected cells, leading to the elimination of these cells

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749.0, 205.0
21.0, 21.0

p3

p3

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000143 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c12 : 1

m127*m11*0.1

nodelay

--

true

0

false

PMID: 16332394,11110698 Ligation of GpVI leads to the phosphorylation of FcR gamma-chain by the Src-family kinases Fyn and Lyn, which are also required for activation of these cells

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77.0, 597.0
21.0, 21.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m25*m46*0.1

nodelay

--

true

0

false

PMID: 16332394,11557981,11248803 The murine NKG2D molecules recognize Rae-1 and H-60, MHC-I related ¡Èsuicude¡É molecules expressed on tumor cells that can target these cells to killing by NKG2D-expressing immune cells

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45.0, 561.0
21.0, 21.0

p30

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e25

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m48*m25*0.1

nodelay

--

true

0

false

PMID: 16332394,11557981,11248803 The murine NKG2D molecules recognize Rae-1 and H-60, MHC-I related ¡Èsuicude¡É molecules expressed on tumor cells that can target these cells to killing by NKG2D-expressing immune cells

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103.0, 447.0
17.0, 17.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000065959

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m25*m40822*0.1

nodelay

--

true

0

false

PMID: 16332394,11973127 It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2

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87.0, 395.0
17.0, 17.0

p32

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000060587 e25

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m35488*m25*0.1

nodelay

--

true

0

false

PMID: 16332394,11973127 It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2

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94.0, 322.0
19.0, 19.0

p32

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000062251

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m25*m37142*0.1

nodelay

--

true

0

false

PMID: 16332394,11973127 It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2

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106.0, 282.0
19.0, 19.0

p32

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066832 e25

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m41689*m25*0.1

nodelay

--

true

0

false

PMID: 16332394,11973127 It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2

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557.0, 697.0
21.0, 21.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018212 MO000018210

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m2893*m2891*0.1

nodelay

--

true

0

false

PMID: 16332394,9396764,10562324,10359120 Besides the classical immunoreceptor Fc¦ÃRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain

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601.0, 209.0
21.0, 21.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018210 e67

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c109 : 1
stoichiometry:c111 : 1

m2891*m67*0.1

nodelay

--

true

0

false

PMID: 16332394,9396764,10562324,10359120 Besides the classical immunoreceptor Fc¦ÃRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain

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869.0, 357.0
21.0, 21.0

p36

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063027 MO000017802

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c115 : 1
stoichiometry:c117 : 1

m37910*m2557*0.1

nodelay

--

true

0

false

PMID: 16332394,9396764,10562324,10359120 Besides the classical immunoreceptor Fc¦ÃRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain

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469.0, 493.0
21.0, 21.0

p36

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017802 MO000018212

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c116 : 1

m2557*m2893*0.1

nodelay

--

true

0

false

PMID: 16332394,9396764,10562324,10359120 Besides the classical immunoreceptor Fc¦ÃRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain

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793.0, 225.0
21.0, 21.0

p3

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000144 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m128*m11*0.1

nodelay

--

true

0

false

PMID: 16332394,11110698 Ligation of GpVI leads to the phosphorylation of FcR gamma-chain by the Src-family kinases Fyn and Lyn, which are also required for activation of these cells

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657.0, 1137.0
21.0, 21.0

p36

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018210 MO000062732

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c118 : 1
stoichiometry:c120 : 1

m2891*m37618*0.1

nodelay

--

true

0

false

PMID: 16332394,9396764,10562324,10359120 Besides the classical immunoreceptor Fc¦ÃRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain

Go back
881.0, 1037.0
21.0, 21.0

p36

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017802 MO000062732

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m2557*m37618*0.1

nodelay

--

true

0

false

PMID: 16332394,9396764,10562324,10359120 Besides the classical immunoreceptor Fc¦ÃRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain

Go back
414.0, 406.0
19.0, 19.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018210 MO000017802

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m2891*m2557*0.1

nodelay

--

true

0

false

PMID: 16332394 It should be noted that the FcR gamma-chain and CD3 zeta-chain can form heterodimers in NK-cells and thus association of the above receptors (in particular the NKp46 molecule) with both sidechains in such heterodimers cannot be excluded.

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290.0, 1118.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e74 MO000066771

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m74*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11323674 These include receptors associated with the ITAM-bearing DAP12 adapter, like TREM-1, which participates in acute inflammatory reactions PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

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270.0, 1218.0
19.0, 19.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e76 MO000017432

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m76*m2258*0.1

nodelay

--

true

0

false

PMID: 16332394,16081415,14970179 These include receptors associated with the ITAM-bearing DAP12 adapter, like TREM-1, which participates in acute inflammatory reactions and SIRP¦Â1, a counterreceptor of CD47, which is involved in transendothelial migration of neutrophils ; as well as PIRL¦Â, a novel receptor for CD99-related ligands

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282.0, 1386.0
19.0, 19.0

p44

p45

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e78 MO000070851

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m78*m45690*0.1

nodelay

--

true

0

false

PMID: 16332394,16081415,14970179 hese include receptors associated with the ITAM-bearing DAP12 adapter, like TREM-1, which participates in acute inflammatory reactions and SIRP¦Â1, a counterreceptor of CD47, which is involved in transendothelial migration of neutrophils ; as well as PIRL¦Â, a novel receptor for CD99-related ligands

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382.0, 1594.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e81 e80

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m81*m80*0.1

nodelay

--

true

0

false

PMID: 16332394,8962144,9218786 These include CEACAM3 (also known as CD66b or CGM1), a receptor of Neisseria gonorrheae Opa proteins

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426.0, 1426.0
19.0, 19.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e82

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 16332394,12864848 In heterologous expression systems, Opa-expressing gonococci were able to induce the phosphorylation of the CEACAM3 ITAM

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542.0, 194.0
19.0, 19.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e83 MO000008301

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m83*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,9029132 The Syk tyrosine kinase is also present in neutrophils and it becomes activated by ligation of ¦Â2 integrins on the surface of neutrophils

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501.0, 1417.0
21.0, 21.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e85 MO000066771

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m85*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
889.0, 249.0
21.0, 21.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e12 MO000008301

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m12*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,9171347 The FcR ¦Ã-chain is in turn required for the activation of the Syk tyrosine kinase

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573.0, 1301.0
21.0, 21.0

p49

p50

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e87 MO000066771

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m87*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
385.0, 1045.0
21.0, 21.0

p49

p51

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e89 MO000066771

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m89*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
349.0, 1169.0
21.0, 21.0

p49

p52

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e76 MO000066771

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m76*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
973.0, 1221.0
21.0, 21.0

p49

p53

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e92 MO000066771

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m92*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
965.0, 1305.0
21.0, 21.0

p49

p54

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e94 MO000066771

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m94*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
601.0, 1241.0
21.0, 21.0

p49

p55

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e96 MO000066771

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m96*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
729.0, 1273.0
21.0, 21.0

p49

p56

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e98 MO000066771

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m98*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
749.0, 1229.0
21.0, 21.0

p49

p57

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e100 MO000018210

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m100*m2891*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
861.0, 1313.0
21.0, 21.0

p49

p58

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000069041 MO000018210

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1
stoichiometry:c173 : 1

m43885*m2891*0.1

nodelay

--

true

0

false

PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363 These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRP¦Â1, PILR¦Â,IREM-2,NKG2D-S and MAIR-II , as well as the FcR ¦Ã-chain-associated PIR-A and and ILT-1/LILRA molecules

Go back
933.0, 1585.0
21.0, 21.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e103 e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m103*m104*0.1

nodelay

--

true

0

false

PMID: 16332394,12163569,11544516,12719478 One such receptor is Dectin-1, a C-type lectin on the surface of macrophages, which is the predominant receptor for the fungal antigen ¦Â-glucan

Go back
1222.0, 202.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017426 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m2254*m14*0.1

nodelay

--

true

0

false

PMID: 16332394 After the initial, collagen-induced activation step, platelets are further activated through other cell surface receptors including the AlphaIIbbeta3 integrins

Go back
1065.0, 1577.0
21.0, 21.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018217 MO000017705

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m2898*m2465*0.1

nodelay

--

true

0

false

PMID: 16332394,14630197 The major receptor on mast cells is Fcvar epsilonRI, a conventional Fc-receptor for IgE, which associates with the FcR gamma-chain and transmits an ITAM- and Syk-dependent activation signal

Go back
709.0, 1045.0
21.0, 21.0

p60

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e106 MO000018210

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m106*m2891*0.1

nodelay

--

true

0

false

PMID: 16332394,14630197 The major receptor on mast cells is Fcvar epsilonRI, a conventional Fc-receptor for IgE, which associates with the FcR gamma-chain and transmits an ITAM- and Syk-dependent activation signal

Go back
730.0, 1178.0
19.0, 19.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e108 MO000066771

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m108*m41628*0.1

nodelay

--

true

0

false

PMID: 16332394,15471863,12893283 Basophils and mast cells also express the DAP12-associated CD200R3 and the LMIR2 receptor, which is able to associate with either DAP12 or the FcR gamma-chain

Go back
918.0, 170.0
19.0, 19.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e110 MO000008301

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m110*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,12387735 The PSGL-1 adhesion molecule has been shown to activate Syk and downstream gene transcription through a mechanism involving ITAM-dependent interaction of moesin with the Syk SH2 domains , indicating an ITAM-based mechanism in general cytoskeletal regulation.

Go back
770.0, 422.0
19.0, 19.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e13 MO000023102

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m13*m6914*0.1

nodelay

--

true

0

false

PMID: 16332394,12387735 The PSGL-1 adhesion molecule has been shown to activate Syk and downstream gene transcription through a mechanism involving ITAM-dependent interaction of moesin with the Syk SH2 domains , indicating an ITAM-based mechanism in general cytoskeletal regulation.

Go back
926.0, 202.0
20.0, 20.0

p65

p65

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e113 e112

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m113*m112*0.1

nodelay

--

true

0

false

PMID: 16332394,11850456,10828067,15173175 Tamalin, a metabotropic glutamate receptor-associated neuronal scaffolding protein also known as GRASP and , contains an ITAM sequence, which becomes phosphorylated by the Src-family kinases Src and Fyn, leading to the recruitment of the Syk tyrosine kinase

Go back
974.0, 206.0
20.0, 20.0

p65

p66

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000000143 e112

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m127*m112*0.1

nodelay

--

true

0

false

PMID: 16332394,11850456,10828067,15173175 Tamalin, a metabotropic glutamate receptor-associated neuronal scaffolding protein also known as GRASP and , contains an ITAM sequence, which becomes phosphorylated by the Src-family kinases Src and Fyn, leading to the recruitment of the Syk tyrosine kinase

Go back
921.0, 405.0
21.0, 21.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e114 MO000008301

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c198 : 1

m114*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,11850456,10828067,15173175 Tamalin, a metabotropic glutamate receptor-associated neuronal scaffolding protein also known as GRASP and , contains an ITAM sequence, which becomes phosphorylated by the Src-family kinases Src and Fyn, leading to the recruitment of the Syk tyrosine kinase

Go back
545.0, 961.0
21.0, 21.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Cell_WithoutCellWall_

--

e111

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c201 : 1

m111*0.1

nodelay

--

true

0

false

PMID: 16332394,12387735 The PSGL-1 adhesion molecule has been shown to activate Syk and downstream gene transcription through a mechanism involving ITAM-dependent interaction of moesin with the Syk SH2 domains , indicating an ITAM-based mechanism in general cytoskeletal regulation.

Go back
889.0, 505.0
21.0, 21.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e117 e118

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m117*m118*0.1

nodelay

--

true

0

false

PMID: 16332394,10899310,10993906,9133424 Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins

Go back
842.0, 338.0
19.0, 19.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e15 MO000008301

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m15*m1066*0.1

nodelay

--

true

0

false

PMID: 16332394,7961845 Platelet activation by fibrinogen leads to the tyrosine phosphorylation of Syk

Go back
853.0, 621.0
21.0, 21.0

p69

p70

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000066849 e118

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m41706*m118*0.1

nodelay

--

true

0

false

PMID: 16332394,10899310,10993906,9133424 Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins

Go back
873.0, 665.0
19.0, 19.0

p71

p71

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e120

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m120*0.1

nodelay

--

true

0

false

PMID: 16332394,10899310,10993906,9133424 Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins

Go back
918.0, 646.0
19.0, 19.0

p71

p72

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e119

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m119*0.1

nodelay

--

true

0

false

PMID: 16332394,10899310,10993906,9133424 Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins

Go back
910.0, 434.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000008301 e15

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m1066*m15*0.1

nodelay

--

true

0

false

PMID: 16332394,11719224,12171941 biochemical studies suggest a direct interaction between alphaIIb¦Â3 and Syk

Go back
345.0, 233.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066771 MO000070820

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m41628*m45659*0.1

nodelay

--

true

0

false

PMID: 16332394,15085135 Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively

Go back
611.3551297247947, 40.88439112607803

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 135.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
111.41002523947678, 348.2368313415563

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
65.0, 303.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
113.0, 295.21592049628157

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
77.0, 256.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
121.64717014237685, 308.54933707270436

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
125.0, 110.11262413157466

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
585.2621748682334, 716.3557139602772

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.5424360051262, 127.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 669.5302996026871

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.4389139907996, 125.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 122.53408116969578

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.5116931692603, 127.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0434774709407, 131.24179168397913

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.9990311984343, 364.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.2477732363923, 192.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.542103132152, 515.6044420517894

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.7081452165539, 194.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 472.38918856175997

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.0, 236.56673000211504

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.8947993633637, 1070.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.1267167741107, 127.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 115.0856580228888

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.0, 1032.9090218578287

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.3488480248167, 197.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.9775944791077, 1049.598319585933

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0, 1050.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.22952389139425, 127.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.6392587538184, 191.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.87222208642754, 418.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 1107.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 130.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.90210372263255, 1130.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 117.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
220.0, 1191.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.0, 1228.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.7294278030124, 1234.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
223.0, 1408.7825910378433

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.0, 1411.722373185794

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.94028500029066, 1405.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 1597.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
311.0, 1537.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.6374626626937, 1538.5527339886228

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.0, 1450.6568542494924

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 269.8466608896548

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.39950093555115, 1445.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0297015069195, 133.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.1076361930003, 212.67171727505703

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.2594582762159, 132.90023827808193

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.0, 1445.5362681228169

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 130.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 1438.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
585.422689183156, 1329.9888255616481

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 130.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.79439707508925, 1315.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.995907143046, 260.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
405.85292509550175, 1073.0110604196834

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.0, 130.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.99165389529247, 1056.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 1180.2479428480121

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.0, 130.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.11771765799355, 1190.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1001.7873373466687, 1194.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.0, 130.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 1232.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.9900187110228, 1316.399500935551

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1233.3716911948197, 228.99136068862452

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.0, 130.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 1321.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.5482356569453, 1269.5833037019938

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 130.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.8900320860664, 1254.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
741.6613232239648, 1301.9726188666864

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.0, 130.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 1288.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.3353308826887, 1257.887768469836

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0, 127.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1168.0, 225.18773164479833

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 1243.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
874.0656857399641, 1341.9287019053334

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 127.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.4437601569801, 1334.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.0, 1544.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 1589.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 1547.8185818291893

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 1590.0436361005711

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1050.0, 1536.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1083.0, 1553.6564023547028

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.1804964634343, 221.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.0947004722519, 1072.1679840384063

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.0, 127.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 1058.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.3530221474871, 1199.8620067455258

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.0, 130.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
749.0, 1190.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.8425169829246, 128.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.0, 194.65685424949237

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.2289466130344, 185.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.0, 276.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.9846341581821, 329.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.7081432770395, 415.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.796029752168, 441.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.2501634822136, 229.6770283510817

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
948.8139928513253, 129.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.0, 124.91152490811936

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.0, 217.66648525378213

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
987.9402850002907, 134.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 132.32332041740196

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
939.0, 118.86820282948725

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.1838880911814, 133.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.1129463263483, 39.15286761306317

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 328.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 331.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.5968358571538, 982.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.4047842686429, 523.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
843.0, 516.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.830325002023, 505.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.0, 526.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.0, 591.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.8, 513.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0831832227035, 638.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.0, 665.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.9033562111058, 350.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.9240068653966, 684.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.8864276343346, 611.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.0, 664.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 335.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.2066029361167, 333.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.0, 433.4068801374159

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.0, 130.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.0, 188.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.4, 135.8

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.68067699991667, 119.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.0, 185.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 31.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.19776902317903, 129.6921915811266

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.0, 258.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
269.0, 130.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.4779987422176, 232.6942019871142

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.0, 254.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.010776798481, 123.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.76990552946845, 287.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
214.0, 330.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.8201683526586, 327.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 273.5390488795451

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.9867195334049, 20.460772280773355

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
219.0, 225.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.9712946111931, 325.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 270.5698363015431

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.0, 129.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.9801433780941, 305.5633042384537

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 267.3094525329482

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 122.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.8026368532014, 267.7660289173913

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 264.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 412.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.6058500848516, 36.97702611721219

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 130.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.7168279846056, 373.10963642744616

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
214.0, 500.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.2665186418611, 130.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
219.8623479330104, 509.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
214.0, 671.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 130.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.9979110225841, 716.1828093948019

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.0, 130.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.9498150255613, 505.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 29.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 552.3069737577591

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.972366065959, 577.6643638388299

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 130.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0, 576.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 765.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.0, 130.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.87756565835207, 786.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.5922945715538, 716.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.0, 130.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 755.5129373480347

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.0, 220.98266599986107

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.0, 130.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 851.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.91599903935696, 878.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.9344688025527, 797.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 130.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 832.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 935.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 130.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.93163436434034, 970.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.8881281107504, 835.3332047511127

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.3260780821423, 135.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 130.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 835.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
88.3206894885279, 812.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
72.0, 774.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
80.0, 877.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1161.0, 360.4195317762593

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1245.9207002305477, 360.44778558789653

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1174.8208100192876, 350.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
105.02039682051046, 549.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
88.0, 626.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.5325719930081, 251.77846408158624

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
98.0, 581.1118111700375

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
62.808987532707135, 529.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
73.86504039586868, 546.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
66.0, 576.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.80965657391589, 469.49980822330707

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
74.0, 458.3592553320612

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
115.0, 177.67844583466123

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
67.0, 383.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.90057332348651, 418.32332041740193

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
103.0, 138.3212832998692

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back