1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16410796.csml convertedTime:2009.07.01.10:53

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TLR signaling.
Authors Kawai T, Akira S.
Affiliation Exploratory Research for Advanced Technology, Japan Science and TechnologyAgency, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract The Toll-like receptor (TLR) family plays an instructive role in innate immuneresponses against microbial pathogens, as well as the subsequent induction ofadaptive immune responses. TLRs recognize specific molecular patterns found in abroad range of microbial pathogens such as bacteria and viruses, triggeringinflammatory and antiviral responses and dendritic cell maturation, which resultin the eradication of invading pathogens. Individual TLRs interact withdifferent combinations of adapter proteins and activate various transcriptionfactors such as nuclear factor (NF)-kappaB, activating protein-1 and interferonregulatory factors, driving a specific immune response. This review outlines therecent advances in our understanding of TLR-signaling pathways and their rolesin immune responses. Further, we also discuss a new concept of TLR-independentmechanisms for recognition of microbial pathogens.
PMID 16410796
Model Abstract

Entity

G010228:IFN-beta MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000065:RIP1 MO000000078:MEK1{active} MO000000212:TRAF6 MO000000248:IKK{active} MO000000276:AP-1 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000009393:MEK2{active} MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016608:IKK-i MO000016882:LPS MO000016899:FADD MO000016966:MKK3 MO000019005:MKK6 MO000019331:TBK1 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000022125:TAB2 MO000022136:Ubc13 MO000022224:dsRNA MO000022528:TIRAP MO000038355:MKK6{p} MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041541:TAB3 MO000042006:TLR8(h) MO000042012:TLR9 MO000042126:TLR7 e1: e10: e11:TLR1:TLR2:triacyl lipopeptide e12:TLR2:TLR6 e13:diacyl lipopeptide e14:diacyl lipopeptide:TLR2:TLR6 e15:flagellin e16:flagellin:TLR5 e17:loxoribine e18:loxoribine:TLR7 e19:ssRNA e2: e20:ssRNA:TLR7 e21:imidazoquinolines e22:imidazoquinolines:TLR8(h) e23:ssRNA:TLR8(h) e24:CpG motif DNA e25:CpG DNA:TLR9 e26:hemozoin e27:hemozoin:TLR9 e28:LPS:TLR4 e29:IkappaB{p}:NF-kappaB e3: e30:IkappaB:NF-kappaB e31:NF-kappaB e32:protein remnants e33:IkappaB{p}{ub}:NF-kappaB e34:NF-kappaB e35:LPS:TLR4:TIRAP e36:LPS:TLR4:TIRAP:MYD88 e37:LPS:TLR4:TIRAP:MYD88:IRAK-4 e38:IRAK1 e39:LPS:TLR4:TIRAP:MYD88:IRAK4:IRAK1 e4: e40:LPS:TLR4:MYD88:IRAK4{p}:IRAK1{p} e41:TRAF6{active} e42:Uev1A e43:TRAF6:Ubc13:Uev1A e44:TAB1:TAB2:TAB3:TAK1 e45:TAB1:TAB2:TAB3:TAK1 e46:IKK e47:MKK3{p} e48:JNK{active} e49:p38{active} e5:TLR1:TLR2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:triacyl lipopeptide e60: e61: e62: e63:ERK{active} e64:AP-1{p} e65:LPS:TLR4:TRAM e66:LPS:TLR4:TRAM:TRIF e67:dsRNA:TLR3:TRIF:RIP1 e68:NF-kappaB{active} e69:dsRNA:TLR4:TRIF:TRAF6 e7: e70:LPS:TLR4:TRAM:TRIF:TBK1 e71:LPS:TLR4:TRAM:TRIF:TBK1:IKK-i e72:(IRF-3)2 e73:(IRF-3)2 e74: e75: e76: e77:CpG:TLR9:MYD88 e78:CpG:TLR9:MYD88:IRAK1:IRAK4:IRF7 e79:dsRNA:RIG-I:IPS1:FADD:RIP1 e8: e80:CpG:TLR9:IRAK1:IRAK4:IRF7[p} e81:CpG:TLR9:IRAK1:IRAK4:IRF7[p}{ub} e82:(IRF7)2 e83:(IRF7)2 e84:IRF-5:MYD88 e85:IRF-5 e86:IRF-5 e87:dsRNA e88:RIG-I e89:dsRNA:RIG-I e9: e90:LGP2 e91:dsRNA:LGP2 e92:Mda5 e93:dsRNA:Mda5 e94:IPS1 e95:dsRNA:RIG-I:IPS1 e96:dsRNA:Mda5:IPS1 e97:IPS1:TRAF6 e98:TRIF:IPS1 e99:e99

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p8 p9
Model Detail
691.0, 1531.0
42.0, 42.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p52

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
690.0, 670.0
28.0, 28.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p37

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1002.0, 774.0
36.0, 36.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p35

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1174.0, 682.0
28.0, 28.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p33

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1284.0, 1408.0
32.0, 32.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43 p68

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
607.0, 603.0
34.0, 34.0

MEK1{active}

--

MO000000078

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000078

--

Go back
788.0, 256.0
32.0, 32.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p45

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
772.0, 464.0
32.0, 32.0

IKK{active}

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28 p72

p14

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1126.0, 980.0
26.0, 26.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39 p40

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
391.0, 383.0
42.0, 42.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1037.0, 1245.0
38.0, 38.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p61 p62

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
464.0, 724.0
32.0, 32.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
749.0, 617.0
30.0, 30.0

MEK2{active}

--

MO000009393

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m1135

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009393

--

Go back
1131.0, 263.0
34.0, 34.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p53 p59

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1103.0, 287.0
34.0, 34.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1176.0, 292.0
32.0, 32.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
546.0, 274.0
35.0, 35.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1330.0, 26.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1110.0, 1730.0
36.0, 36.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p68

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
1203.0, 455.0
34.0, 34.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
989.0, 577.0
30.0, 30.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
642.0, 258.0
36.0, 36.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1318.0, 178.0
36.0, 36.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1366.0, 176.0
26.0, 26.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
1365.0, 233.0
30.0, 30.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p1

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
1356.0, 580.0
40.0, 40.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1354.0, 698.0
36.0, 36.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1359.0, 407.0
33.0, 33.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
1248.0, 300.0
32.0, 32.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
1044.0, 324.0
32.0, 32.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
1612.0, 584.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1242.0, 258.0
28.0, 28.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1062.0, 674.0
28.0, 28.0

MKK6{p}

--

MO000038355

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p32 p34

true true true true

csml-variable:Double

m16567

10

false

infinite

0

unit false false false
TRANSPATHMO000038355

--

Go back
1052.0, 252.0
32.0, 32.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23 p57

p20 p54

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1282.0, 1326.0
36.0, 36.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p42 p71

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
720.0, 260.0
32.0, 32.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1351.0, 1359.0
34.0, 34.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

p43 p45

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
1357.0, 645.0
38.0, 38.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p41

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
367.0, 567.0
42.0, 42.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p50

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
1259.0, 367.0
26.0, 26.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
733.0, 929.0
29.0, 29.0

TLR8(h)

--

MO000042006

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10

true true true true

csml-variable:Double

m155646

10

false

infinite

0

unit false false false
Affymetrix220832_at
EnsemblENSG00000101916
HGNCTLR8
OMIM300366
ProteomeHumanPSD/TLR8
RefSeqNM_016610
TRANSPATHMO000042006
UnigeneHs.272410
UniProtQ9NR97

--

Go back
723.0, 1067.0
34.0, 34.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
593.0, 813.0
30.0, 30.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
203.97338256093116, 161.22927534600763
1211.6097418528213, 1909.7729824138523

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
200.64715806206874, 195.41927107239144
1174.420866842829, 1793.4258594689318

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1360.5, 341.79005322077467
31.683795191778305, 44.20994677922556

TLR1:TLR2:triacyl lipopeptide

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1360.0, 465.70165745856366
32.66850828729282, 36.29834254143646

TLR2:TLR6

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1608.0, 470.7970123022847
39.54305799648507, 25.70298769771529

diacyl lipopeptide

--

e13

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1359.5, 517.2284822903285
32.086254358597905, 44.7715177096715

diacyl lipopeptide:TLR2:TLR6

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1616.0, 703.8457436103844
39.97987522640371, 24.654256389615618

flagellin

--

e15

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1361.5, 762.6057323779371
28.088651891351436, 34.39426762206298

flagellin:TLR5

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1630.0, 811.0
60.0, 34.0

loxoribine

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
669.0, 847.5690607734806
29.187845303867398, 32.43093922651932

loxoribine:TLR7

--

e18

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1623.0, 893.1581889936417
41.30673098004823, 21.341811006358252

ssRNA

--

e19

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p8 p10

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
203.97338256093116, 161.22927534600763
1211.6097418528213, 1909.7729824138523

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
704.0, 882.1933701657458
31.32596685082873, 34.806629834254146

ssRNA:TLR7

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1615.0, 975.1009251471825
58.05719091673675, 32.89907485281749

imidazoquinolines

--

e21

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
743.5, 973.3949341776373
24.1774704215964, 29.605065822362942

imidazoquinolines:TLR8(h)

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
741.0, 1019.1325966850827
30.48066298342542, 33.867403314917134

ssRNA:TLR8(h)

--

e23

cso30:c:Complex

cso30:i:CC_Extracellular

--

p10

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1602.0, 1169.5
60.0, 13.0

CpG motif DNA

--

e24

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p11

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
702.5, 1111.565405765706
26.488251958007005, 32.434594234294295

CpG DNA:TLR9

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p53 p60

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1610.0, 1261.5895710681245
51.90075693860387, 29.410428931875526

hemozoin

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
671.0, 1145.9337016574582
25.259668508287298, 28.066298342541437

hemozoin:TLR9

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1265.5, 177.97750374937513
36.768371938010326, 45.02249625062489

LPS:TLR4

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p18 p25

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
887.5, 532.7069187006791
33.893374931180034, 47.293081299320974

IkappaB{p}:NF-kappaB

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
228.20557739798758, 187.53468832691428
1163.1453521787075, 1857.1621564520424

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
627.5, 509.09432923472195
32.899064048449254, 45.90567076527804

IkappaB:NF-kappaB

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
889.0, 862.6795580110496
38.088397790055254, 42.32044198895027

NF-kappaB

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p44 p46 p70

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
786.0, 794.0821367030442
27.84606547960942, 26.917863296955773

protein remnants

--

e32

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
890.5, 695.1653514406314
34.998164800880886, 48.8346485593687

IkappaB{p}{ub}:NF-kappaB

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
781.0, 1354.7955801104972
38.88397790055249, 43.20441988950276

NF-kappaB

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1183.5, 165.33859423747475
32.00734079647642, 44.661405762525234

LPS:TLR4:TIRAP

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p19

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1094.0, 161.2647058823529
27.441176470588236, 45.73529411764706

LPS:TLR4:TIRAP:MYD88

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19 p23

p20

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1004.0, 161.76470588235293
31.94117647058823, 53.235294117647065

LPS:TLR4:TIRAP:MYD88:IRAK-4

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
984.0, 283.90000000000003
32.79999999999999, 24.599999999999994

IRAK1

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23 p57

p21 p54

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
922.0, 164.9411764705882
28.235294117647054, 47.058823529411775

LPS:TLR4:TIRAP:MYD88:IRAK4:IRAK1

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p22

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
273.0351378465419, 233.56916104350177
1073.4862312816008, 1765.0932110188644

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
854.0, 163.76470588235298
28.941176470588232, 48.235294117647065

LPS:TLR4:MYD88:IRAK4{p}:IRAK1{p}

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23 p24

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
896.0, 288.0
32.0, 32.0

TRAF6{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p26 p56 p69

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
857.0, 335.97756087744
38.14449587442141, 23.522439122559874

Uev1A

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
973.5, 375.3026243347403
29.166452560102776, 40.697375665259685

TRAF6:Ubc13:Uev1A

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p27

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1197.0, 375.7352941176471
29.55882352941176, 49.26470588235294

TAB1:TAB2:TAB3:TAK1

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p27

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1122.0, 436.3823529411766
27.970588235294116, 46.617647058823536

TAB1:TAB2:TAB3:TAK1

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28 p30 p31

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
716.0, 344.0
32.0, 32.0

IKK

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p72

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1183.0, 579.0
34.0, 34.0

MKK3{p}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p33 p35

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
1178.0, 818.0
28.0, 28.0

JNK{active}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p33

p39

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1002.0, 938.0
36.0, 36.0

p38{active}

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34 p35

p38

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1362.5, 291.41559740043317
27.427262122979506, 33.584402599566744

TLR1:TLR2

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
460.44269281319924, 1262.5930534648328
433.4848530045691, 426.75731538374646

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
507.26228587514515, 1272.7065814318757
253.47159002501834, 413.612839550571

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
466.09333335515845, 1268.288992992542
422.1835719206513, 415.36543632832803

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
466.90056771829535, 1269.1652913814207
420.56910319437696, 413.612839550571

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
460.44269281319924, 1262.5930534648328
433.4848530045691, 426.75731538374646

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
460.44269281319924, 1262.5930534648328
433.4848530045691, 426.75731538374646

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
466.90056771829535, 1269.1652913814207
420.56910319437696, 413.612839550571

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
776.8785631629037, 1437.8527312405006
27.081751831434662, 26.613621260036975

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
705.8419392068467, 1560.534505683465
76.68726449801497, 75.36166144353632

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
460.44269281319924, 1262.5930534648328
433.4848530045691, 426.75731538374646

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1571.0, 297.1555360281195
34.37609841827769, 22.344463971880494

triacyl lipopeptide

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
562.6126336149923, 1452.2404780966433
13.72782835556977, 7.17519652475592

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
562.1542225684614, 1430.8423441294722
46.98713226938953, 91.81292364983693

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
581.8658975692781, 1490.5580668285543
7.334576744490062, 7.962096359877455

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
798.0, 878.0
28.0, 28.0

ERK{active}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p37

p40

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1127.0, 1143.0
26.0, 26.0

AP-1{p}

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38 p39 p40

--

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
781.5, 169.66379152138006
37.50761607634428, 52.33620847861994

LPS:TLR4:TRAM

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

p42

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
680.0, 184.1470588235294
32.91176470588235, 54.852941176470594

LPS:TLR4:TRAM:TRIF

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p47

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1352.0, 1465.9411764705883
31.235294117647054, 52.05882352941177

dsRNA:TLR3:TRIF:RIP1

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
889.0, 1067.3480662983425
29.38674033149172, 32.65193370165746

NF-kappaB{active}

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44 p46 p70

p17

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1355.0, 1549.1470588235295
26.911764705882355, 44.85294117647059

dsRNA:TLR4:TRIF:TRAF6

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p45

p46

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
219.89216733521033, 168.9143528009099
1188.211681353266, 1827.7135150637048

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
589.0, 182.8529411764706
30.08823529411764, 50.14705882352941

LPS:TLR4:TRAM:TRIF:TBK1

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p48 p61

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
476.0, 188.1470588235294
32.91176470588235, 54.852941176470594

LPS:TLR4:TRAM:TRIF:TBK1:IKK-i

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p48

p62 p73

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
374.5, 814.5572404599234
35.47825362439593, 43.44275954007665

(IRF-3)2

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
650.5, 1350.5572404599232
35.47825362439593, 43.44275954007665

(IRF-3)2

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p52

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
544.0, 831.5659074962548
216.5567291828644, 361.5396241442737

--

e74

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false true false

--

Go back
544.0, 831.5659074962548
216.5567291828644, 361.5396241442737

--

e75

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false true false

--

Go back
544.0, 831.5659074962548
216.5567291828644, 361.5396241442737

--

e76

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false true false

--

Go back
627.5, 1156.6098366672786
33.24628372178381, 46.3901633327216

CpG:TLR9:MYD88

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53 p57

p54

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
501.0, 782.9705882352943
30.61764705882353, 51.02941176470589

CpG:TLR9:MYD88:IRAK1:IRAK4:IRF7

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p55

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1261.0, 1695.7352941176468
29.558823529411764, 49.26470588235295

dsRNA:RIG-I:IPS1:FADD:RIP1

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p68

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
224.13717660835107, 201.17173020813223
1139.865624379734, 1796.687908512334

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
504.0, 965.5
31.5, 52.5

CpG:TLR9:IRAK1:IRAK4:IRF7[p}

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p56

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
478.0, 1131.9117647058824
28.852941176470587, 48.08823529411765

CpG:TLR9:IRAK1:IRAK4:IRF7[p}{ub}

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
407.0, 1353.596685082873
33.66298342541436, 37.40331491712708

(IRF7)2

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p58

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
535.0, 1464.436464088398
34.707182320441994, 38.56353591160221

(IRF7)2

--

e83

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p58

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1182.0, 1435.5027624309391
36.447513812154696, 40.49723756906078

IRF-5:MYD88

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
825.0, 1417.0
38.0, 38.0

IRF-5

--

e85

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

--

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
1125.0, 1389.0
38.0, 38.0

IRF-5

--

e86

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61 p62

p60

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
952.0, 1508.0
32.0, 32.0

dsRNA

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63 p64 p65

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
949.0, 1639.8137452203662
38.41014288589254, 23.686254779633728

RIG-I

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p63

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1021.5, 1569.47608731878
29.82786202299617, 36.523912681219805

dsRNA:RIG-I

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p66

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
235.4572013367269, 233.42910761535438
1134.6615125489416, 1773.124796801451

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1154.5, 1534.820285771785
26.627490440732544, 43.17971422821493

LGP2

--

e90

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p64

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1123.0, 1493.0386740331494
33.26519337016575, 36.961325966850836

dsRNA:LGP2

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
935.0, 1404.3000000000004
41.59999999999999, 31.2

Mda5

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p65

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1053.5, 1473.5860689885014
29.738043659390094, 36.413931011498086

dsRNA:Mda5

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p67

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1027.0, 1686.0
26.0, 60.0

IPS1

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p66 p67 p69 p71

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1090.5, 1625.7931730592773
26.664892640851523, 37.206826940723076

dsRNA:RIG-I:IPS1

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

p68 p72

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1202.5, 1596.648008808956
27.48559368691503, 38.35199119104423

dsRNA:Mda5:IPS1

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
790.0, 1695.0607734806629
36.84530386740332, 40.93922651933702

IPS1:TRAF6

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

p70

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1261.0, 1835.5138121546963
29.237569060773478, 32.48618784530386

TRIF:IPS1

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
381.0, 183.1470588235294
29.911764705882348, 49.852941176470594

e99

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p73

p49

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1470.0, 238.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019396 MO000019397

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3963*m3964*0.1

nodelay

--

true

0

false

PMID: 16410796 TLR1/2 and TLR2/6 discriminate triacyl lipopeptide and diacyl lipopeptide, respectively.

Go back
1498.0, 1061.5
20.5, 20.5

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042006 e19

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m155646*m19*0.1

nodelay

--

true

0

false

PMID: 16410796, 14976262, 14579267, 12032557 human TLR8 mediates the recognition of imidazoquinolines and ssRNA.

Go back
1485.0, 1165.0
21.0, 21.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m19828*m24*0.1

nodelay

--

true

0

false

PMID: 16410796, 11130078, 15345224, 12900525, 15630134 TLR9 recognizes bacterial and viral CpG DNA motifs and malaria pigment hemozoin.

Go back
1484.0, 1264.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m19828*m26*0.1

nodelay

--

true

0

false

PMID: 16410796, 11130078, 15345224, 12900525, 15630134 TLR9 recognizes bacterial and viral CpG DNA motifs and malaria pigment hemozoin.

Go back
1277.0, 77.5
21.5, 21.5

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 16410796, 9851930, 10201887 LPS of Gram-negative bacteria is recognized by TLR4 (hToll)

Go back
779.0, 539.0
25.0, 25.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e30 MO000000248

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m30*m207*0.1

nodelay

--

true

0

false

PMID: 16410796 Upon stimulation with various TLR ligands, IkappaBs are phosphorylated at serine residues by an IKK complex.

Go back
896.0, 616.0
23.0, 23.0

p15

p15

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e29

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 16410796 The phosphorylation targets IkappaBs for ubiquitination and degradation by the 26S proteasome, allowing NF-kappaB to be released into the nucleus and to bind to the kappaB site.

Go back
896.0, 796.0
23.0, 23.0

p16

p16

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e33

e32 e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16410796 The phosphorylation targets IkappaBs for ubiquitination and degradation by the 26S proteasome, allowing NF-kappaB to be released into the nucleus and to bind to the kappaB site.

Go back
892.0, 1172.0
23.0, 23.0

p17

p17

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e68

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c49 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 16410796 The phosphorylation targets IkappaBs for ubiquitination and degradation by the 26S proteasome, allowing NF-kappaB to be released into the nucleus and to bind to the kappaB site.

Go back
1200.0, 60.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e28

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m6810*m28*0.1

nodelay

--

true

0

false

PMID: 16410796 TIRAP/Mal and TRAM are required for the activation of MyD88- and Trif-dependent pathways, respectively.

Go back
1141.0, 53.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000016573

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m35*m1572*0.1

nodelay

--

true

0

false

PMID: 16410796 MyD88 is a central adapter shared by almost all TLRs. The association of TLRs and MyD88 recruits members of the interleukin-1 receptor-associated kinase (IRAK) family.

Go back
1489.0, 297.5
21.5, 21.5

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 16410796 TLR1/2 and TLR2/6 discriminate triacyl lipopeptide and diacyl lipopeptide, respectively.

Go back
1052.0, 80.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000039077

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m36*m17258*0.1

nodelay

--

true

0

false

PMID: 16410796 The association of TLRs and MyD88 recruits members of the interleukin-1 receptor-associated kinase (IRAK) family.

Go back
961.0, 105.0
21.0, 21.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e38 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m38*m37*0.1

nodelay

--

true

0

false

Go back
878.0, 100.5
24.5, 24.5

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 16410796 In response to stimuli, IRAK4 and IRAK1 are sequentially phosphorylated and dissociated from MyD88.

Go back
865.0, 277.0
21.0, 21.0

p23

p23

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e40

e38 MO000039077 e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 16410796 In response to stimuli, IRAK4 and IRAK1 are sequentially phosphorylated and dissociated from MyD88.

Go back
830.0, 293.5
20.5, 20.5

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m183*m40*0.1

nodelay

--

true

0

false

Go back
806.0, 90.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e28 MO000041132

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c119 : 1

m28*m19005*0.1

nodelay

--

true

0

false

PMID: 16410796, 14556004 TRAM is required for the activation of the Trif-dependent pathway, indicating that TRAM is an adapter linking TLR4 to Trif.

Go back
998.0, 329.5
20.5, 20.5

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000022136 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m41*m6443*m42*0.1

nodelay

--

true

0

false

PMID: 16410796, 16056267 TRAF6 which contains an N-terminal RING domain that is found in a number of E3 ubiquitin ligases, and forms a complex with Ubc13 and Uev1A, serving as the ubiquitin E3 ligase to promote synthesis of lysine 63-linked polyubiquitin chains.

Go back
1125.0, 389.0
21.0, 21.0

p27

p27

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e44 e43

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m44*m43*0.1

nodelay

--

true

0

false

PMID: 16410796, 16056267 TRAF6 in turn activates transforming growth factor-beta-activated protein kinase 1 (TAK1), a member of the MAP kinase kinase kinase (MAP3K) family, in a ubiquitin-dependent manner.

Go back
753.0, 413.0
21.0, 21.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e46 e45

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c79 : 1

m46*m45*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 activates the IKK complex that leads to NF-kappaB activation.

Go back
1150.0, 342.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016574 MO000016588 MO000022125 MO000041541

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m1573*m1583*m6433*m19389*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 forms a complex with TAB1, TAB2 and TAB3.

Go back
1469.0, 412.5
22.5, 22.5

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019422 MO000019397

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 16410796 TLR1/2 and TLR2/6 discriminate triacyl lipopeptide and diacyl lipopeptide, respectively.

Go back
1211.0, 530.5
18.5, 18.5

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016966 e45

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c221 : 1
stoichiometry:c87 : 1

m1875*m45*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 simultaneously phosphorylates two members of the MAP kinase kinase family, MKK3 and MKK6, which subsequently activate JNK and p38.

Go back
1064.0, 612.0
23.0, 23.0

p31

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000019005 e45

MO000038355

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c220 : 1
stoichiometry:c90 : 1

m3613*m45*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 simultaneously phosphorylates two members of the MAP kinase kinase family, MKK3 and MKK6, which subsequently activate JNK and p38.

Go back
1181.0, 749.0
21.0, 21.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 MO000038355

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1

m48*m16567*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 simultaneously phosphorylates two members of the MAP kinase kinase family, MKK3 and MKK6, which subsequently activate JNK and p38.

Go back
1232.0, 732.0
23.0, 23.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c97 : 1
stoichiometry:c96 : 1

m48*m47*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 simultaneously phosphorylates two members of the MAP kinase kinase family, MKK3 and MKK6, which subsequently activate JNK and p38.

Go back
1008.0, 872.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 MO000038355

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c103 : 1
stoichiometry:c99 : 1

m63*m16567*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 simultaneously phosphorylates two members of the MAP kinase kinase family, MKK3 and MKK6, which subsequently activate JNK and p38.

Go back
1056.0, 860.0
23.0, 23.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e47

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m63*m47*0.1

nodelay

--

true

0

false

PMID: 16410796 TAK1 simultaneously phosphorylates two members of the MAP kinase kinase family, MKK3 and MKK6, which subsequently activate JNK and p38.

Go back
749.0, 753.0
21.0, 21.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 MO000009393

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c109 : 1
stoichiometry:c105 : 1

m65*m1135*0.1

nodelay

--

true

0

false

PMID: 16410796 ERK is also activated in response to TLR ligands through the activation of MEK1 and MEK2, although an upstream kinase activating MEK1 and MEK2 in TLR signaling remains unknown.

Go back
677.0, 749.0
21.0, 21.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 MO000000078

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m65*m70*0.1

nodelay

--

true

0

false

PMID: 16410796 ERK is also activated in response to TLR ligands through the activation of MEK1 and MEK2, although an upstream kinase activating MEK1 and MEK2 in TLR signaling remains unknown.

Go back
1129.0, 1065.0
21.0, 21.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000276 e49

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m219*m64*0.1

nodelay

--

true

0

false

PMID: 16410796 AP-1 activation in TLR signaling is mostly mediated by MAP kinases such as c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). PMID: 16410796 TAK1 simultaneously activates the MAP kinase pathway, which results in phosphorylation (P) and activation of AP-1.

Go back
1173.0, 1065.0
21.0, 21.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000276 e48

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c114 : 1

m219*m49*0.1

nodelay

--

true

0

false

PMID: 16410796 AP-1 activation in TLR signaling is mostly mediated by MAP kinases such as c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). PMID: 16410796 TAK1 simultaneously activates the MAP kinase pathway, which results in phosphorylation (P) and activation of AP-1.

Go back
1486.0, 473.5
20.5, 20.5

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m12*m13*0.1

nodelay

--

true

0

false

PMID: 16410796 TLR1/2 and TLR2/6 discriminate triacyl lipopeptide and diacyl lipopeptide, respectively.

Go back
1075.0, 1062.5
18.5, 18.5

p40

p40

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000276 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1

m219*m66*0.1

nodelay

--

true

0

false

PMID: 16410796 AP-1 activation in TLR signaling is mostly mediated by MAP kinases such as c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). PMID: 16410796 TAK1 simultaneously activates the MAP kinase pathway, which results in phosphorylation (P) and activation of AP-1.

Go back
1637.0, 1333.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 MO000041446

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 16410796 Trif is the sole adapter utilized by TLR3.

Go back
697.0, 105.0
21.0, 21.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m18998*m68*0.1

nodelay

--

true

0

false

PMID: 16410796, 14556004 TRAM is required for the activation of the Trif-dependent pathway, indicating that TRAM is an adapter linking TLR4 to Trif.

Go back
1434.0, 1414.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041437 MO000000065

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m19305*m71*0.1

nodelay

--

true

0

false

PMID: 16410796, 15064760 Trif?RIP1 interactions are responsible for NF-kappaB activation in TLR3 signaling.

Go back
922.0, 998.0
19.0, 19.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c133 : 1
stoichiometry:c131 : 1

m31*m72*0.1

nodelay

--

true

0

false

PMID: 16410796, 15064760 Trif?RIP1 interactions are responsible for NF-kappaB activation in TLR3 signaling.

Go back
1505.0, 1517.0
21.0, 21.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041437 MO000000212

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m19305*m183*0.1

nodelay

--

true

0

false

PMID: 16410796 Trif possesses three typical TRAF6-binding domains in the N-terminal region, which mediate interaction with TRAF6.

Go back
828.0, 976.0
23.0, 23.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e69

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m31*m74*0.1

nodelay

--

true

0

false

PMID: 16410796 Trif activates NF-kappaB by recruiting TRAF6.

Go back
649.0, 113.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e66 MO000019331

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m69*m3902*0.1

nodelay

--

true

0

false

PMID: 16410796 TLR4 also recruits TRAM and Trif, which interacts with TBK1.

Go back
553.0, 113.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e70 MO000016608

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m75*m1599*0.1

nodelay

--

true

0

false

PMID: 16410796 TBK1 together with IKKi mediates phosphorylation of IRF3.

Go back
336.0, 480.0
23.0, 23.0

p49

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e99

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c148 : 1
stoichiometry:c147 : 1

m977*m104*0.1

nodelay

--

true

0

false

PMID: 16410796 TBK1 together with IKKi mediates phosphorylation of IRF3.

Go back
1481.0, 589.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 16410796, 11607032 TLR3 recognizes double-stranded RNA (dsRNA) that is produced from many viruses during replication.

Go back
375.0, 695.0
26.0, 26.0

p50

p50

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 16410796 Phosphorylated IRF3 is dimerized and translocated into nucleus to bind DNA.

Go back
382.0, 1254.0
19.0, 19.0

p51

p51

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 16410796 Phosphorylated IRF3 is dimerized and translocated into nucleus to bind DNA.

Go back
699.0, 1435.0
25.0, 25.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e73

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c153 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 16410796 Initial induction of IFNbeta is largely dependent on IRF3 activation.

Go back
788.0, 1140.0
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000016573

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m25*m1572*0.1

nodelay

--

true

0

false

PMID: 16410796 After ligand ligation, these TLRs elicit the MyD88-dependent pathway to regulate inflammatory responses by activating NF-kappaB and AP-1.

Go back
549.0, 728.5
22.5, 22.5

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007702 e77 MO000039077 e38

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m980*m82*m17258*m38*0.1

nodelay

--

true

0

false

PMID: 16410796 In pDCs, IRF7 is constitutively expressed and forms a signaling complex with MyD88, IRAK1 and IRAK4.

Go back
508.0, 888.0
23.0, 23.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e78

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 16410796 In response to ligand stimulation, IRF7 is phosphorylated by IRAK1, dimerized and translocated into nuclei.

Go back
508.0, 1055.5
24.5, 24.5

p56

p56

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e80 e41

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c183 : 1
stoichiometry:c166 : 1

m85*m41*0.1

nodelay

--

true

0

false

PMID: 16410796 In response to ligand stimulation, IRF7 is phosphorylated by IRAK1, dimerized and translocated into nuclei. Additionally, TRAF6-dependent ubiquitination is also required for IRF7 activation.

Go back
475.0, 1239.0
26.0, 26.0

p57

p57

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e81

e82 e77 MO000039077 e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 16410796 In response to ligand stimulation, IRF7 is phosphorylated by IRAK1, dimerized and translocated into nuclei.

Go back
414.0, 1474.0
19.0, 19.0

p58

p58

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 16410796 In response to ligand stimulation, IRF7 is phosphorylated by IRAK1, dimerized and translocated into nuclei.

Go back
1229.0, 1345.0
21.0, 21.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007700 MO000016573

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m979*m1572*0.1

nodelay

--

true

0

false

PMID: 16410796, 15665823 It is also reported that IRF5 interacts with MyD88.

Go back
1473.0, 705.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m3966*m15*0.1

nodelay

--

true

0

false

PMID: 16410796, 11323673 TLR5 recognizes bacterial flagellin.

Go back
1134.0, 1454.5
19.5, 19.5

p60

p60

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e25 e86

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m25*m91*0.1

nodelay

--

true

0

false

PMID: 16410796 IRF5 translocates into the nucleus in response to ligand stimulation.

Go back
1113.0, 1321.0
21.0, 21.0

p61

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007700 e70

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c91 : 1
stoichiometry:c182 : 1

m979*m75*0.1

nodelay

--

true

0

false

PMID: 16410796, 15210742, 15556946 Although it is reported that IRF5 is phosphorylated by TBK1 and IKKi in vitro, cells deficient in TBK1 and IKKi show normal inflammatory responses in response to various TLR ligands.

Go back
1056.0, 1344.0
24.0, 24.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

MO000007700 e71

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c207 : 1
stoichiometry:c185 : 1

m979*m76*0.1

nodelay

--

true

0

false

PMID: 16410796, 15210742, 15556946 Although it is reported that IRF5 is phosphorylated by TBK1 and IKKi in vitro, cells deficient in TBK1 and IKKi show normal inflammatory responses in response to various TLR ligands.

Go back
956.0, 1576.0
23.0, 23.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e88 e87

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m93*m92*0.1

nodelay

--

true

0

false

PMID: 16410796 The helicase domain of RIG-I interacts with dsRNA.

Go back
1080.0, 1544.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e87 e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m92*m95*0.1

nodelay

--

true

0

false

PMID: 16410796, 16116171 LGP2 is also related to RIG-I and Mda5, but lacks the CARD-like domains, and is therefore suggested to function as a negative regulator for RIG-I and Mda5.

Go back
984.0, 1460.0
23.0, 23.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e92 e87

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m97*m92*0.1

nodelay

--

true

0

false

PMID: 16410796, 11805321, 12015121, 15563593 Melanoma differentiation-associated gene 5 (Mda5) (also known as Helicard) is structurally similar to RIG-I, which also contains two CARD-like and a single helicase domain, and is suggested to mediate antiviral responses.

Go back
1030.0, 1634.0
19.0, 19.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e89 e94

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m94*m99*0.1

nodelay

--

true

0

false

PMID: 16410796 IPS-1 interacts with RIG-I and Mda5 via the CARD domain.

Go back
1161.0, 1605.0
21.0, 21.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e93 e94

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m98*m99*0.1

nodelay

--

true

0

false

PMID: 16410796 IPS-1 interacts with RIG-I and Mda5 via the CARD domain.

Go back
1197.0, 1681.0
21.0, 21.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 MO000016899 e95

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m71*m1814*m100*0.1

nodelay

--

true

0

false

PMID: 16410796, 16127453 IPS-1 interacts with FADD and RIP-1 via non-CARD region to facilitate NF-kappaB, rather than IRF3 activation.

Go back
918.0, 1706.0
19.0, 19.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e94 e41

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c88 : 1
stoichiometry:c208 : 1

m99*m41*0.1

nodelay

--

true

0

false

PMID: 16410796, 16153868 VISA contains two TRAF6-binding domains, and interacts with TRAF6 through these domains.

Go back
1463.0, 815.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19940*m17*0.1

nodelay

--

true

0

false

PMID: 16410796, 11812998, 14976261, 14976262, 14579267, 12032557, 15034168, 15723075 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single-stranded RNA (ssRNA) derived from human immunodeficiency virus type I (HIV-1), vesicular stomatitis virus (VSV) and influenza virus, and certain siRNAs.

Go back
985.0, 993.0
21.0, 21.0

p70

p70

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e97

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c211 : 1
stoichiometry:c210 : 1

m31*m102*0.1

nodelay

--

true

0

false

PMID: 16410796, 16153868 VISA?TRAF6 interaction is required for NF-kappaB but not IRF3 activation.

Go back
1188.0, 1820.0
23.0, 23.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e94 MO000041125

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m99*m18998*0.1

nodelay

--

true

0

false

PMID: 16410796, 16153868 VISA interacts with Trif.

Go back
668.0, 404.0
23.0, 23.0

p72

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e46 e95

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m46*m100*0.1

nodelay

--

true

0

false

PMID: 16410796 IPS-1 initiates intracellular signaling pathways leading to IRF3, NF-kappaB and AP-1 via TBK1/IKKi, IKKalpha/IKKbeta and MAP kinases, respectively.

Go back
491.0, 311.0
25.0, 25.0

p73

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e71

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 16410796 IPS-1 initiates intracellular signaling pathways leading to IRF3, NF-kappaB and AP-1 via TBK1/IKKi, IKKalpha/IKKbeta and MAP kinases, respectively.

Go back
1493.0, 893.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19940*m19*0.1

nodelay

--

true

0

false

PMID: 16410796, 11812998, 14976261, 14976262, 14579267, 12032557, 15034168, 15723075 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single-stranded RNA (ssRNA) derived from human immunodeficiency virus type I (HIV-1), vesicular stomatitis virus (VSV) and influenza virus, and certain siRNAs.

Go back
1448.0, 980.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042006 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m155646*m21*0.1

nodelay

--

true

0

false

PMID: 16410796, 14976262, 14579267, 12032557 human TLR8 mediates the recognition of imidazoquinolines and ssRNA.

Go back
1392.0, 197.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1393.0, 484.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1031.0, 810.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1034.023148626429, 883.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1077.4485413211876, 613.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1025.2156796083011, 702.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
714.0, 698.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 774.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.6867029780244, 698.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.0, 770.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0, 637.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
760.301672079202, 647.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1515.0, 484.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1139.0, 1006.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.0, 1086.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1038.0, 974.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1146.0, 1006.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1150.82217557528, 1086.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1184.2920426544615, 846.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1095.5174713247359, 1006.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1090.0, 1081.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 901.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
806.2942002165319, 109.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1399.2455218124676, 489.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.8242321900428, 103.66775017202728

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.0, 116.27631631003015

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1318.0, 1344.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1384.0, 683.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1392.9475473706154, 1345.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.4716084425557, 133.20749157624036

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.06735586479, 130.2141339463039

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.9585612815268, 126.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1385.0, 1387.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1316.0, 1424.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1396.0, 600.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1388.9987028429207, 1433.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.8417420849886, 1017.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 1100.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.3567442625101, 1022.9418255533183

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1385.0, 1393.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.0, 288.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1389.660893921221, 1531.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.3499304188223, 905.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 999.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.3628560079031, 1004.9363099176591

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1510.0, 600.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0978598748408, 141.3758568448589

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 142.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.4376015698018, 134.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.399257096111, 141.24189555258423

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 142.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.933295802115, 134.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.70537358140035, 425.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 503.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.34107428516063, 233.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.0, 609.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1401.9855816161194, 606.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 721.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 858.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
401.0, 1268.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 1460.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.0, 1394.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.0, 1132.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.9620037020273, 297.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.871949132409, 1154.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 740.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.5093437043872, 758.8563274869385

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1390.0, 716.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.312656189937, 284.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.6365425808622, 309.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.2950039375453, 751.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 834.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 911.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.0, 1018.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.3526867907002, 1080.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.27103076532603, 1180.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.7357957375498, 1265.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1502.0, 716.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 1191.3233695713157

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.0, 291.4403043144567

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.0, 316.05251606102166

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 1391.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 1484.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.0, 1274.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.0, 297.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1210.9711254108329, 1366.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1144.0, 1427.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.9661748118896, 1438.7348869752666

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1396.889064047065, 723.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 1138.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1075.0, 1283.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.0, 1342.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.6548510575515, 320.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1058.0, 1283.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 1364.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.0, 1607.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.0, 1540.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.0, 1588.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.0, 828.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 1528.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.0, 1556.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1103.0, 1533.3517178529796

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.0, 1436.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0, 1490.0977344098767

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.0, 1475.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1037.0, 1606.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.0, 1661.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.0, 1644.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1083.0, 1510.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1395.0, 248.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1496.0, 828.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 1628.8376739215316

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1182.0, 1616.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1214.6050235032856, 1440.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1146.0, 1704.5267399752993

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1117.0, 1650.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1218.0, 1696.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.0, 1716.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0, 243.0

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
835.0, 1716.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0, 905.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.9921104517297, 829.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0484903342966, 1014.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.0, 1021.7371846536944

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1053.0, 1725.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1203.6083951756864, 1362.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.0, 1835.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.4436087949382, 376.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 423.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.611035105282, 434.5619108483891

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.0, 243.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.45134822335075, 229.8551517954508

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.0, 829.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1082.7898696961713, 483.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1150.0, 473.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1522.0, 904.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.9998886135168, 900.0422157710476

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.0, 945.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1479.0, 992.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
775.9998615952873, 988.047058009384

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.0, 946.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1522.0335858293438, 915.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1396.9352504244603, 254.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.990745070424, 1037.3846988685898

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.0, 1086.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1514.0, 1176.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.985231778837, 1129.485873891305

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.0, 1088.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1515.0, 1276.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.9203980503625, 1163.125741854874

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1305.0326527670904, 52.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1296.2405150182822, 106.31430532697995

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1285.3035786553762, 99.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1390.0, 308.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 534.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 552.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 496.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
905.0, 580.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 639.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.0, 744.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 808.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.0, 819.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 905.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.8215808360975, 1195.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1519.0, 308.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1215.740167782401, 90.80844517744048

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1221.953332999577, 89.95493768444089

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1202.872807424013, 83.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1158.871832634471, 81.46676484962448

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1148.0, 81.99820893849378

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1118.7616431473434, 74.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.4779925266494, 110.20441309091663

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.2146877531331, 110.99711880421034

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.3289916300826, 103.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
975.2014087267618, 133.90927411784804

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1399.2855018221364, 313.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
983.3969320118102, 132.68333665795151

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.5037553862376, 126.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.2399915200255, 131.7839864320407

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.1716813201745, 125.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.0, 212.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.0, 289.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.0, 270.81501442845206

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.0, 193.2945718166242

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.0, 287.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 304.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1392.0, 424.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.8058166818636, 212.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.0, 310.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.0, 340.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
895.0, 341.4652307417023

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.7097557461819, 350.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1154.0, 400.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.0, 410.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1003.0, 396.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.0, 376.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 434.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1389.0, 263.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.9620891357644, 425.77790526039075

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1134.0, 321.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1171.6839244307548, 324.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.5700838368532, 322.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.7509022872978, 355.9807861400872

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1169.0, 360.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.0, 489.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1208.7540371932673, 549.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 320.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.0, 599.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1399.923410283849, 430.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.0, 635.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 233.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1189.0, 710.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.0, 770.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 697.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1202.0, 708.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1204.051374836607, 755.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1205.0, 613.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1020.0, 810.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 895.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back