1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16446382.csml convertedTime:2009.07.01.10:54

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title All is not Toll: new pathways in DNA recognition.
Authors Wagner H, Bauer S.
Affiliation Institute of Medical Microbiology, Munchen, Germany. h.wagner@lrz.tu-muenchen.de
Abstract Immunological defense depends on the ability of the innate immune system torecognize invading microbes as foreign and thus eliminate them. The Toll-likereceptors (TLRs) help detect foreign invaders by sensing variouspathogen-associated molecules, including microbial RNA and DNA. At present, itis unclear whether and how the immune system distinguishes between microbial andself nucleic acids, as host-derived RNA and DNA also stimulate TLRs. Inaddition, recent studies have revealed the existence of TLR-independent pathwaysthat are activated in response to microbial and host nucleic acids.
PMID 16446382
Model Abstract

Entity

G010329:TNF-alpha G010657:IL-12 p40 MO000000058:NF-kappaB MO000000289:TNF-alpha MO000007694:IRF-3 MO000016573:MyD88 MO000016658:IFN Type I MO000016882:LPS MO000017265:IL-12 MO000017690:BCR MO000017793:Lp MO000018212:FcgammaRIII MO000019331:TBK1 MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000022185:flagellin MO000022224:dsRNA MO000041125:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042130:TLR11 MO000061041:FcgammaRIIA(h) MO000066987:DDX58(RIG-1) MO000103999:IFIH1(Mda-5) e1: e10: e11: e12:TLR ligand e13:TLR ligand: TLR e14:ssRNA e15:ssDNA e16:ssDNA: BCR e17:TLR ligand: TLR: TLR e18:TLR ligand: TLR: TLR: MyD88 e19:TLR ligand: TLR: TLR: TRIF e2: e20:LPS: TLR4 e21:NF-kappaB {activated} e22:IFN type I e23:Lp: TLR2 e24:IKK-alpha:IKK-beta:IKK-gamma e25:ssRNA: TLR8 e26:ssRNA: TLR9 e27:ssDNA: TLR9 e28:flagellin: TLR5 e29:propellin: TLR11 e3: e30:propellin e31:dsRNA:TLR3: TRIF e32:anti DNA IC e33:anti DNA IC {endosomal} e34:anti DNA IC {endosomal}: TLR9 e35:ICs containing U1 small nuclear ribonucleotide proteins e36:ICs containing U1 small nuclear ribonucleotide proteins: TLR7 e38:dsRNA: RIG-1 e39:IPS-1 e4: e40:dsRNA: RIG-1: IPS-1 e41:ssDNA: TLR9: MyD88 e42:ssRNA: TLR8: MyD88 e43:ssRNA: TLR7: MyD88 e44:dsRNA: RIG-1: IPS-1: TBK1: ILL-alpha: IKK-beta: IKK-gamma e46:IRF-3 [activated} e47:dsRNA: Mda-5 e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p5 p6 p7 p8 p9
Model Detail
514.0, 1077.0
30.5, 30.5

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p14

p12

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
519.0, 1146.0
28.0, 28.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p15

p13

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
736.0, 708.0
31.0, 31.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p21 p27 p30 p37 p38 p39

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
846.0, 1061.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
606.0, 598.0
36.0, 36.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
788.0, 268.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p34 p35 p36

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
668.0, 932.0
32.0, 32.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
1101.0, 401.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
762.0, 1141.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
146.0, 386.0
36.0, 36.0

BCR

--

MO000017690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m2450

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
1094.0, 501.0
30.0, 30.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
228.0, 200.0
32.0, 32.0

FcgammaRIII

--

MO000018212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m2893

10

false

infinite

0

unit false false false
TRANSPATHMO000018212

--

Go back
622.0, 270.0
28.0, 28.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
941.0, 353.0
25.0, 25.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
836.0, 155.0
33.0, 33.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
938.0, 454.0
28.0, 28.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
503.0, 158.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
942.0, 554.0
28.5, 28.5

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1096.0, 600.0
32.0, 32.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
517.0, 61.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p32 p41

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
688.0, 212.0
31.0, 31.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p22

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
566.0, 149.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p22

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
241.0, 605.0
25.0, 25.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
235.0, 439.0
26.5, 26.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p25

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
238.0, 682.0
28.0, 28.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p29

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
942.0, 650.0
28.0, 28.0

TLR11

--

MO000042130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m19944

10

false

infinite

0

unit false false false
TRANSPATHMO000042130

--

Go back
360.0, 292.0
32.0, 32.0

FcgammaRIIA(h)

--

MO000061041

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m282320

10

false

infinite

0

unit false false false
Affymetrix203561_at
EnsemblENSG00000143226
HGNCFCGR2A
OMIM146790
ProteomeHumanPSD/FCGR2A
RefSeqNM_021642
TRANSPATHMO000061041
UnigeneHs.119428
UniProtP12318

--

Go back
417.0, 249.0
35.0, 35.0

DDX58(RIG-1)

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
298.0, 226.0
36.5, 36.5

IFIH1(Mda-5)

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
133.75, 124.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
142.0, 144.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
243.0, 384.0
220.41674094020794, 367.9838810611947

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
835.0, 64.5
36.69595782073814, 23.852372583479788

TLR ligand

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
913.625, 149.5
30.748500249958337, 37.65122479586736

TLR ligand: TLR

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p8

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
17.5, 623.625
45.0, 24.75

ssRNA

--

e14

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p2 p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
8.5, 445.0
54.02489626556016, 14.406639004149378

ssDNA

--

e15

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p1 p23

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
152.625, 317.5
29.899308448591906, 36.61139810031661

ssDNA: BCR

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

p24 p26

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
942.625, 210.5
27.939635060823193, 34.211798033661054

TLR ligand: TLR: TLR

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9 p10

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
936.875, 261.5
32.25, 45.0

TLR ligand: TLR: TLR: MyD88

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
771.875, 125.5
32.25, 45.0

TLR ligand: TLR: TLR: TRIF

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p18

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
133.75, 124.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
938.625, 399.5
26.208590234960838, 32.092151308115305

LPS: TLR4

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
789.0, 1024.0
31.0, 31.0

NF-kappaB {activated}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p21 p27 p30 p37 p38 p39

p12 p13 p14 p15 p16 p17

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
481.5, 1040.0
45.0, 24.0

IFN type I

--

e22

cso30:c:mRNA

cso30:i:CC_NuclearEnvelopeLumen

--

p16 p18 p28 p31 p43

p17

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
937.625, 497.5
30.87914514247625, 37.81119813364439

Lp: TLR2

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
621.0, 449.0
38.0, 38.0

IKK-alpha:IKK-beta:IKK-gamma

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
245.625, 562.5
28.960298283619398, 35.46158973504416

ssRNA: TLR8

--

e25

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p2

p35

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
231.625, 636.5
32.34890018330278, 39.61089818363606

ssRNA: TLR9

--

e26

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p3

p36

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
237.625, 478.5
28.298908515247465, 34.6517247125479

ssDNA: TLR9

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p1

p34

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
940.625, 597.5
29.8993084485919, 36.61139810031661

flagellin: TLR5

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
939.625, 692.5
31.90797367105482, 39.07098816863856

propellin: TLR11

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
150.87518862352903, 142.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1098.5, 700.375
34.77152899824253, 22.601493848857643

propellin

--

e30

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
631.875, 133.5
32.25, 45.0

dsRNA:TLR3: TRIF

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p21

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
76.875, 255.5
29.606395668930077, 41.311249770600114

anti DNA IC

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p24 p26

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
276.875, 379.5
29.606395668930077, 41.311249770600114

anti DNA IC {endosomal}

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24 p26

p25

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
347.875, 369.5
32.25, 45.0

anti DNA IC {endosomal}: TLR9

--

e34

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p25

p27 p28

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
16.875, 731.5
29.606395668930077, 41.311249770600114

ICs containing U1 small nuclear ribonucleotide proteins

--

e35

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p29

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
311.875, 721.5
32.25, 45.0

ICs containing U1 small nuclear ribonucleotide proteins: TLR7

--

e36

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p29

p30 p31

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
464.375, 213.5
23.25, 45.0

dsRNA: RIG-1

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p33

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
570.25, 265.5
19.5, 45.0

IPS-1

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
182.5567875770579, 172.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
503.875, 337.5
32.25, 45.0

dsRNA: RIG-1: IPS-1

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p40

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
431.875, 473.5
32.25, 45.0

ssDNA: TLR9: MyD88

--

e41

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p34

p37

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
447.875, 557.5
32.25, 45.0

ssRNA: TLR8: MyD88

--

e42

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p35

p38

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
427.875, 633.5
32.25, 45.0

ssRNA: TLR7: MyD88

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p36

p39

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
561.875, 521.5
44.18173059276931, 61.648926408515315

dsRNA: RIG-1: IPS-1: TBK1: ILL-alpha: IKK-beta: IKK-gamma

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p42

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
606.0, 654.0
36.0, 36.0

IRF-3 [activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p43

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
368.375, 229.5
23.25, 45.0

dsRNA: Mda-5

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
243.0, 384.0
220.41674094020794, 367.9838810611947

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
301.0, 940.0
372.38844764793373, 337.71540782969066

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
341.22072618916224, 948.0033642045851
217.74669005856845, 327.3134958842176

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
305.8542255745541, 944.5074951763717
362.6799964988258, 328.7004174769473

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
306.547686370919, 945.2009559727367
361.2930749060959, 327.3134958842176

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
301.0, 940.0
372.38844764793373, 337.71540782969066

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
301.0, 940.0
372.38844764793373, 337.71540782969066

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
306.547686370919, 945.2009559727367
361.2930749060959, 327.3134958842176

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
572.8366321750277, 1078.6921592729736
23.26478411920024, 21.06075193948656

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
511.8120820949197, 1175.7766707640549
65.87877565466239, 59.637628487378684

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
301.0, 940.0
372.38844764793373, 337.71540782969066

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
243.0, 384.0
220.41674094020794, 367.9838810611947

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
388.7698618250447, 1090.0779366741265
11.792994969662816, 5.678108689096918

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
388.37606034197324, 1073.1444729020545
40.36465201482292, 72.65637362668129

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
405.3095241140457, 1120.400650870628
6.300823729143084, 6.300823729143089

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
145.0, 130.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
148.0, 151.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
156.0, 172.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
84.0, 440.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000042012

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m15*m19828*0.1

nodelay

--

true

0

false

PMID: 16446382 These include TLR3, TLR7/8, and TLR9, which sense double-stranded (ds)RNA, single-stranded (ss)RNA, and ssDNA, respectively. PMID: 16446382 A likely interpretation of these results is that high concentrations of endosomal ssPD-DNA, or other nonstimulatory oligonucleotides, can activate TLR9 in a CpG-independent fashion.

Go back
840.0, 215.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000041125

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m17*m18998*0.1

nodelay

--

true

0

false

PMID: 16446382 The other pathway requires the adaptor molecule TRIF and primarily culminates in the production of type I IFNs.

Go back
874.0, 870.0
27.0, 27.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m18*m21*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12.

Go back
684.0, 1063.0
25.0, 25.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e21 G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c30 : 1
stoichiometry:c33 : 1

m22*m93309*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12.

Go back
692.0, 1143.0
25.0, 25.0

p13

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e21 G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c31 : 1
stoichiometry:c34 : 1

m22*m93589*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12.

Go back
593.0, 1060.0
23.0, 23.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c36 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12.

Go back
592.0, 1128.0
23.0, 23.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c37 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12.

Go back
571.0, 1039.0
25.0, 25.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c35 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12. PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
670.0, 982.0
27.0, 27.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e21 e22

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c29 : 1
stoichiometry:c32 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12. PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
556.0, 996.0
24.0, 24.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e19

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 16446382 The other pathway requires the adaptor molecule TRIF and primarily culminates in the production of type I IFNs.

Go back
1030.0, 602.0
27.0, 27.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 16446382, 11861602, 15229469, 15207506 Other TLRs, in contrast, reside on the cell membrane. These include TLR2, TLR4, TLR5, and TLR11, which recognize lipopeptides, lipopolysaccharide, flagellin, and propellin, respectively.

Go back
79.0, 567.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 MO000042007

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m14*m19823*0.1

nodelay

--

true

0

false

PMID: 16446382 These include TLR3, TLR7/8, and TLR9, which sense double-stranded (ds)RNA, single-stranded (ss)RNA, and ssDNA, respectively.

Go back
1026.0, 698.0
27.0, 27.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042130 e30

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m19944*m31*0.1

nodelay

--

true

0

false

PMID: 16446382, 11861602, 15229469, 15207506 Other TLRs, in contrast, reside on the cell membrane. These include TLR2, TLR4, TLR5, and TLR11, which recognize lipopeptides, lipopolysaccharide, flagellin, and propellin, respectively.

Go back
843.0, 847.0
25.0, 25.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m32*m21*0.1

nodelay

--

true

0

false

PMID: 16446382 TLR3 ligation triggers type 1 interferon genes via the adaptor protein TRIF.

Go back
567.0, 215.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 16446382 TLR3 ligation triggers type 1 interferon genes via the adaptor protein TRIF.

Go back
83.0, 391.0
25.0, 25.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000017690

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m15*m2450*0.1

nodelay

--

true

0

false

PMID: 16446382, 11948342 In this system, the RF+ BCR first recognizes the isotype of the autoantibody, and this recognition triggers the subsequent translocation of the ICs into TLR-expressing endosomes.

Go back
235.0, 263.0
25.0, 25.0

p24

p24

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e32 e16 MO000018212

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c73 : 1
stoichiometry:c69 : 1

m33*m16*m2893*0.1

nodelay

--

true

0

false

PMID: 16446382, 11948342 In this system, the RF+ BCR first recognizes the isotype of the autoantibody, and this recognition triggers the subsequent translocation of the ICs into TLR-expressing endosomes. PMID: 16446382, 15197227, 15668740 Similarly, anti-DNA ICs that are translocated to endosomes via FcgammaRIII-mediated (mouse) or FcgammaRIIa-mediated (human) endocytosis activate the TLR9-dependent production of cytokines, including type I IFNs.

Go back
310.0, 438.0
27.0, 27.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e33 MO000042012

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m34*m19828*0.1

nodelay

--

true

0

false

PMID: 16446382, 15197227, 15668740 Similarly, anti-DNA ICs that are translocated to endosomes via FcgammaRIII-mediated (mouse) or FcgammaRIIa-mediated (human) endocytosis activate the TLR9-dependent production of cytokines, including type I IFNs. PMID: 16446382 Thus, in SLE, both self-RNA and self-DNA can act as ligands for TLR7 and TLR9, respectively, provided they do not contain certain posttranscriptional nucleoside modifications.

Go back
279.0, 295.0
25.0, 25.0

p26

p26

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e32 MO000061041 e16

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c72 : 1

m33*m282320*m16*0.1

nodelay

--

true

0

false

PMID: 16446382, 11948342 In this system, the RF+ BCR first recognizes the isotype of the autoantibody, and this recognition triggers the subsequent translocation of the ICs into TLR-expressing endosomes PMID: 16446382, 15197227, 15668740 Similarly, anti-DNA ICs that are translocated to endosomes via FcgammaRIII-mediated (mouse) or FcgammaRIIa-mediated (human) endocytosis activate the TLR9-dependent production of cytokines, including type I IFNs.

Go back
805.0, 825.0
30.0, 30.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m35*m21*0.1

nodelay

--

true

0

false

PMID: 16446382, 15197227, 15668740 Similarly, anti-DNA ICs that are translocated to endosomes via FcgammaRIII-mediated (mouse) or FcgammaRIIa-mediated (human) endocytosis activate the TLR9-dependent production of cytokines, including type I IFNs.

Go back
479.0, 979.0
25.0, 25.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c79 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 16446382, 15197227, 15668740 Similarly, anti-DNA ICs that are translocated to endosomes via FcgammaRIII-mediated (mouse) or FcgammaRIIa-mediated (human) endocytosis activate the TLR9-dependent production of cytokines, including type I IFNs.

Go back
76.0, 732.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m19940*m36*0.1

nodelay

--

true

0

false

PMID: 16446382, 16368889, 16230478, 16260486 ICs containing U1 small nuclear ribonucleotide proteins, which are found in a subset of SLE patients, activate the TLR7-dependent production of type I IFNs and other proinflammatory cytokines by murine pDCs. PMID: 16446382 Thus, in SLE, both self-RNA and self-DNA can act as ligands for TLR7 and TLR9, respectively, provided they do not contain certain posttranscriptional nucleoside modifications.

Go back
79.0, 683.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 MO000042126

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m14*m19940*0.1

nodelay

--

true

0

false

PMID: 16446382 These include TLR3, TLR7/8, and TLR9, which sense double-stranded (ds)RNA, single-stranded (ss)RNA, and ssDNA, respectively.

Go back
769.0, 821.0
30.0, 30.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m37*m21*0.1

nodelay

--

true

0

false

PMID: 16446382, 16368889, 16230478, 16260486 ICs containing U1 small nuclear ribonucleotide proteins, which are found in a subset of SLE patients, activate the TLR7-dependent production of type I IFNs and other proinflammatory cytokines by murine pDCs.

Go back
427.0, 995.0
25.0, 25.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c88 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 16446382, 16368889, 16230478, 16260486 ICs containing U1 small nuclear ribonucleotide proteins, which are found in a subset of SLE patients, activate the TLR7-dependent production of type I IFNs and other proinflammatory cytokines by murine pDCs.

Go back
463.0, 63.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000066987

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c119 : 1
stoichiometry:c90 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 16446382 In this system, the RNA is recognized by the cytoplasmic helicase domain of the helicase protein retinoic acid?induced gene 1 (RIG-1).

Go back
506.0, 274.0
27.0, 27.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1

m39*m40*0.1

nodelay

--

true

0

false

PMID: 16446382, 15208624, 16177806 The downstream signaling events that result from this recognition require the NH2-terminal caspase recruitment domain (CARD) of RIG-1, which binds to the adaptor molecule Cardif (also called IPS-1.

Go back
310.0, 482.0
27.0, 27.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e27 MO000016573

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c101 : 1

m28*m1572*0.1

nodelay

--

true

0

false

PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
311.0, 567.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e25 MO000016573

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c102 : 1

m26*m1572*0.1

nodelay

--

true

0

false

PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
311.0, 643.0
25.0, 25.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e26 MO000016573

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c103 : 1

m27*m1572*0.1

nodelay

--

true

0

false

PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
729.0, 833.0
29.0, 29.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c104 : 1
stoichiometry:c108 : 1

m42*m21*0.1

nodelay

--

true

0

false

PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
697.0, 853.0
30.0, 30.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e42 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m43*m21*0.1

nodelay

--

true

0

false

PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
665.0, 885.0
30.0, 30.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e43 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m44*m21*0.1

nodelay

--

true

0

false

PMID: 16446382 After ligation of TLR7, TLR8, and TLR9, the adaptor molecule MyD88 is recruited and drives the production of proinflammatory cytokine genes or type 1 interferon genes.

Go back
917.0, 64.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 MO000019395

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m12*m3962*0.1

nodelay

--

true

0

false

PMID: 16446382 Two major signaling pathways are activated upon ligand-driven TLR dimerization.

Go back
568.0, 346.0
27.0, 27.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 e24 e40

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c115 : 1

m3902*m25*m41*0.1

nodelay

--

true

0

false

PMID: 16446382, 15210742 This TLR3-independent induction does not require TRIF, but depends on the kinase TBK1 (TANK-binding kinase-1) and the transcription factor IRF-3 (IFN regulatory factor-3). PMID: 16446382 Cardiff /IPS-1 in turn interacts with Ikkalpha/beta/gamma kinases and thus activates IRF3.

Go back
365.0, 145.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 MO000103999

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c125 : 1
stoichiometry:c124 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 16446382 Another candidate for the sensing of cytoplasmic dsRNA molecules is Mda5 (melanoma differentiation-associated gene 5, also termed Helicard).

Go back
718.0, 602.0
27.0, 27.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c117 : 1
stoichiometry:c121 : 1

m977*m45*0.1

nodelay

--

true

0

false

PMID: 16446382 Cardiff /IPS-1 in turn interacts with Ikkalpha/beta/gamma kinases and thus activates IRF3.

Go back
520.0, 984.0
23.0, 23.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 16446282 Although viral dsRNA is known to be sensed by TLR3, DCs or fibroblasts that lack TLR3 still produce type I IFNs after intracellular introduction of dsRNA molecules.

Go back
1027.0, 403.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c19 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 16446382, 11861602, 15229469, 15207506 Other TLRs, in contrast, reside on the cell membrane. These include TLR2, TLR4, TLR5, and TLR11, which recognize lipopeptides, lipopolysaccharide, flagellin, and propellin, respectively.

Go back
568.0, 63.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 16446382 These include TLR3, TLR7/8, and TLR9, which sense double-stranded (ds)RNA, single-stranded (ss)RNA, and ssDNA, respectively.

Go back
1027.0, 502.0
27.0, 27.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000017793

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c40 : 1

m3964*m2549*0.1

nodelay

--

true

0

false

PMID: 16446382, 11861602, 15229469, 15207506 Other TLRs, in contrast, reside on the cell membrane. These include TLR2, TLR4, TLR5, and TLR11, which recognize lipopeptides, lipopolysaccharide, flagellin, and propellin, respectively.

Go back
1023.0, 215.0
25.0, 25.0

p8

p8

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

e13

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 16446382 Two major signaling pathways are activated upon ligand-driven TLR dimerization.

Go back
872.0, 271.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016573

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 16446382 One pathway requires the adaptor molecule MyD88 and culminates in the production of type I interferons (IFNs) or NF-kappaB?dependent proinflammatory cytokines including TNF and interleukin (IL)-12.

Go back
872.0, 76.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1062.0, 516.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.3185795045254, 296.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 496.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 580.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 656.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.5096012338028, 739.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 515.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.0, 599.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.0, 673.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 862.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 883.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.0, 177.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.1620511210258, 739.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.0408995635705, 739.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.0, 915.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.6241387262427, 298.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.7983219405637, 380.04079188982547

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 373.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 360.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
606.0, 562.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.0526651537367, 84.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
439.0, 95.82736508194239

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.0, 228.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 616.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0793457790559, 623.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.490188052155, 1007.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.197769023179, 690.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.0, 170.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 176.50986776965388

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.3000400080607, 239.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 284.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.0, 284.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 228.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0297771955363, 174.22104021553173

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.0, 228.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
973.0, 416.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.0, 93.26488677998636

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
887.9308708540268, 297.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
765.0, 739.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.7328584522146, 897.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.9892830302331, 1041.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.5302245237162, 1003.7010587965503

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.9043139244146, 1043.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
716.5799382318976, 1045.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.1554175279994, 1048.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
721.2289589627687, 1055.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 1002.4013878696029

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
929.0, 87.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.0, 1077.8016992763962

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.0, 1156.2206057307865

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
684.0, 972.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 1076.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 1156.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 1052.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.7218109753595, 1075.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.6857134627292, 1143.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.5978308147678, 1016.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.9822558784682, 171.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1060.0, 416.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0, 516.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
52.0, 597.9278956114879

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
51.0, 648.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
111.79031003426371, 584.819634460558

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.0, 580.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
112.0, 696.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.0, 661.997193704501

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
63.0, 452.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
115.0, 452.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
107.0, 455.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.0, 373.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.0, 576.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1065.0, 616.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.0, 616.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.0, 672.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 712.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1061.0, 712.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.2221365379228, 179.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 178.79310344827587

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 228.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.0, 179.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.0, 76.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 739.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.1776950265319, 872.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
45.0, 419.05701381977434

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
116.0, 404.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
108.0, 356.4585460028801

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.0, 421.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.0, 452.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.0, 421.5672416142839

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
106.0, 276.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 288.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 94.64176904712873

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
183.0, 290.8

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
106.0, 278.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 320.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
245.0, 232.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.0, 308.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
183.0, 312.78700925063515

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
380.0, 408.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.0, 739.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.613571991078, 855.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.0, 1004.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.0, 88.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0, 415.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
106.67316363984155, 700.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
46.0, 747.0573097607281

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.0, 744.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.0, 767.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 747.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
756.0, 739.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.0, 851.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 1016.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.0, 476.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 88.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 76.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 249.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 301.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.0, 288.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 496.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.31916612995764, 291.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 580.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.80757198874915, 294.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 656.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back