1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16474426.csml convertedTime:2009.07.01.10:54

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Antiviral innate immunity pathways.
Authors Seth RB, Sun L, Chen ZJ.
Affiliation Howard Hughes Medical Institute, Department of Molecular Biology, University ofTexas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Abstract Recent studies have uncovered two signaling pathways that activate the hostinnate immunity against viral infection. One of the pathways utilizes members ofthe Toll-like receptor (TLR) family to detect viruses that enter the endosomethrough endocytosis. The TLR pathway induces interferon production throughseveral signaling proteins that ultimately lead to the activation of thetranscription factors NF-kappaB, IRF3 and IRF7. The other antiviral pathway usesthe RNA helicase RIG-I as the receptor for intracellular viral double-strandedRNA. RIG-I activates NF-kappaB and IRFs through the recently identified adaptorprotein MAVS, a CARD domain containing protein that resides in the mitochondrialmembrane. MAVS is essential for antiviral innate immunity, but it also serves asa target of Hepatitis C virus (HCV), which employs a viral protease to cleaveMAVS off the mitochondria, thereby allowing HCV to escape the host immunesystem.
PMID 16474426
Model Abstract

Entity

G010228:IFN-beta G010713:IRF-7 MO000000022:p38 MO000000023:JNK MO000000058:NF-kappaB MO000000065:RIP1 MO000000145:Jak1 MO000000148:Tyk2 MO000000205:TNFR MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK(IRAK-1) MO000000248:IKK MO000000289:TNF-alpha MO000007694:IRF-3 MO000007702:IRF-7 MO000007758:ISGF-3gamma(IRF9) MO000013119:STAT1 MO000013120:STAT2 MO000016573:MyD88 MO000016597:IL-1beta MO000016608:IKK-i MO000016660:IFNbeta MO000016882:LPS MO000016899:FADD MO000016963:TRAF3 MO000019331:TBK1 MO000019394:TLR4 MO000019398:TLR3 MO000019399:TLR5 MO000019479:protein remnants MO000019704:STAT1{p} MO000022185:flagellin MO000022224:dsRNA MO000038329:IKK-beta{p} MO000039077:IRAK-4 MO000041125:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000045747:HMGA1 MO000055971:ATF-2:c-Jun MO000066987:DDX58 MO000094908:MAVS e1: e10: e11:IL-1betaR e12:IL-1beta:IL-1betaR e13:TNF-alpha:TNFR e14:NF-kappaB:IkappaB e15:NF-kappaB:IkappaB{p} e16:NF-kappaB:IkappaB{p}{ub} e17:NF-kappaB{active} e18:(IRF-3{p})2 e19:(IRF-3{p})2 e2: e20:JNK{active} e21:MAVS:DDX58 e22:p38{active} e23:ATF-2{p}:c-Jun{p} e24:IFN-beta e25:IFN-beta:enhanceosome complex e26:enhancesome complex e28:IFN-beta:IFN-betaR e29:IFN-betaR e3: e30:Jak1{active} e31:Tyk2{active} e32:STAT2{p} e34:STAT1{p}:STAT2{p}:IRF9 e35:ISG e36:ISG:ISG3 e37:IFN-alpha e38:IFN-alpha:IRF7{p} e39:IFN-alpha e4: e40:LPS:TLR4 e41:flagellin:TLR5 e42:LPS:TLR4:MYD88 e44:LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6 e45:LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6{ub} e46:Ubc13:Uev1A e47:TAK1:TAB1:TAB2 e48:TAK1:TAB1:TAB2 {active} e49:dsRNA:TLR3:TRIF e5:dsRNA:DDX58 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IKK{active} e60: e61: e62: e63:LPS:TLR4:TRIF e64:dsRNA:TLR3:TRIF:RIP1:TRAF6 e65:NF-kappaB{active} e66:dsRNA:TLR3:TRIF:RIP1:TRAF6:TBK1 e67:MYD88:TRAF3 e68:TRIF:TRAF3 e69: e7: e70: e71: e72:ssRNA e73:ssRNA:TLR8 e74:ssRNA:TLR7 e75:CpG DNA e76:CpG DNA: TLR9 e77:MYD88:TRAF6:IRF7 e78:MYD88:TRAF6:IRF7:IRAK1 e79:MYD88:TRAF6{ub}:IRF7:IRAK1 e8: e80:IRF-7{p} e81:MAVS:TRAF6 e82:FADD:RIP1:MAVS e83:MAVS:IKK-alpha e84:MAVS:IKK-i e85:NS3/4A e86:MAVS:NS3/4A e87:IRF-3{active} e88:MYD88:TRAF6{ub}:IRAK1 e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p8 p9
Model Detail
701.0, 1337.5
29.5, 29.5

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p20

p30

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
928.0, 1268.0
32.0, 32.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

p31

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
843.0, 743.0
34.0, 34.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
919.0, 871.0
26.0, 26.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
463.0, 1039.0
26.0, 26.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p48 p68

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
567.0, 231.0
34.0, 34.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p62

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
358.0, 1262.0
28.0, 28.0

Jak1

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
341.0, 1457.0
30.0, 30.0

Tyk2

--

MO000000148

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m132

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000148

--

Go back
265.0, 829.0
29.0, 29.0

TNFR

--

MO000000205

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m176

10

false

infinite

0

unit false false false
TRANSPATHMO000000205

--

Go back
384.0, 548.0
32.0, 32.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1198.0, 502.0
36.0, 36.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
907.0, 231.0
34.0, 34.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p47 p55 p61

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
857.0, 297.0
38.0, 38.0

IRAK(IRAK-1)

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p56

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
460.0, 664.0
32.0, 32.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p5 p63

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
89.0, 829.0
29.0, 29.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
672.0, 756.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11 p69

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1120.0, 1340.0
32.0, 32.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p33 p34 p55

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
415.0, 1207.0
41.0, 41.0

ISGF-3gamma(IRF9)

--

MO000007758

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m991

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007758

--

Go back
457.0, 1553.0
30.0, 30.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p22

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
402.0, 1346.0
28.0, 28.0

STAT2

--

MO000013120

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p27

true true true true

csml-variable:Double

m1358

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013120

--

Go back
748.0, 228.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p50 p55

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
79.0, 707.0
26.0, 26.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
495.0, 491.0
34.0, 34.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p33 p66

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
79.0, 1211.0
34.0, 34.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p21

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
663.0, 23.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
480.0, 312.0
32.0, 32.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
1119.0, 355.0
26.0, 26.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p51

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
787.0, 831.0
26.0, 26.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p34 p49

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
659.0, 175.0
34.0, 34.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
904.0, 500.0
32.0, 32.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1127.0, 171.0
36.0, 36.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
492.0, 1140.0
24.0, 24.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p67

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
668.0, 1552.0
32.0, 32.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25 p22

p28

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
1119.0, 23.0
28.0, 28.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
631.0, 511.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p35

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1200.0, 636.0
32.0, 32.0

IKK-beta{p}

--

MO000038329

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

--

true true true true

csml-variable:Double

m16544

10

false

infinite

0

unit false false false
TRANSPATHMO000038329

--

Go back
830.0, 234.0
28.0, 28.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
517.0, 261.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p46 p51

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
913.0, 541.0
38.0, 38.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p45

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
674.0, 878.0
28.0, 28.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10 p11

p12

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
1054.0, 1510.0
36.0, 36.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p34 p57

p59

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
1064.0, 668.0
32.0, 32.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
993.0, 737.0
30.0, 30.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1087.0, 615.0
34.0, 34.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
597.0, 1145.0
30.0, 30.0

HMGA1

--

MO000045747

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m23351

10

false

infinite

0

unit false false false
InterProIPR000637
TRANSPATHMO000045747

--

Go back
838.0, 1098.0
28.0, 28.0

ATF-2:c-Jun

--

MO000055971

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17

true true true true

csml-variable:Double

m31298

10

false

infinite

0

unit false false false
TRANSPATHMO000055971

--

Go back
794.0, 458.0
28.0, 28.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p60

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
458.0, 590.0
28.0, 28.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60 p61 p62 p64 p65 p66

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
288.91590918275335, 149.18337047630303
1061.7082488330639, 1541.6003773056075

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
313.14539423594374, 151.74601841389483
1029.120416299998, 1447.6830529524216

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
262.5, 679.8400702987698
26.753954305799645, 41.159929701230226

IL-1betaR

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
266.5, 742.4716071037053
26.10633632975225, 50.528392896294676

IL-1beta:IL-1betaR

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
268.5, 893.4968208726158
23.509975882481914, 45.50317912738436

TNF-alpha:TNFR

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
442.5, 891.7153807698717
26.36577237127145, 32.2846192301283

NF-kappaB:IkappaB

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
409.5, 934.9843359440093
21.246125645725716, 26.015664055990676

NF-kappaB:IkappaB{p}

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
369.5, 1042.8958506915512
28.66838860189969, 35.104149308448584

NF-kappaB:IkappaB{p}{ub}

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
664.0, 1120.0
24.0, 24.0

NF-kappaB{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p19

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
666.5, 971.5854024329279
26.471921346442258, 32.41459756707215

(IRF-3{p})2

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
733.5, 1121.5260789868355
29.787035494084325, 36.47392101316447

(IRF-3{p})2

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p19

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
288.91590918275335, 149.18337047630303
1061.7082488330639, 1541.6003773056075

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
967.0, 943.0
26.0, 26.0

JNK{active}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p17

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
582.0, 531.9005524861878
28.88950276243094, 32.099447513812166

MAVS:DDX58

--

e21

cso30:c:Complex

cso30:i:CC_Extracellular

--

p60

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
843.0, 915.0
34.0, 34.0

p38{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
819.0, 1199.0
26.0, 26.0

ATF-2{p}:c-Jun{p}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p17

p19

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000055971

--

Go back
630.0, 1285.5
60.0, 13.0

IFN-beta

--

e24

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p18

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
834.0, 1283.5
60.0, 17.0

IFN-beta:enhanceosome complex

--

e25

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p18

p20

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
629.0, 1217.0588235294117
22.76470588235294, 37.94117647058823

enhancesome complex

--

e26

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p19

p18

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
263.5, 1295.82657311993
25.406270554702914, 49.17342688007016

IFN-beta:IFN-betaR

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p23 p24 p32

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
264.5, 1224.8998242530756
30.615114235500876, 47.10017574692443

IFN-betaR

--

e29

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p21

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
310.1500741594147, 170.41753545296422
1019.2399188797413, 1499.1320473522856

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
358.0, 1382.0
28.0, 28.0

Jak1{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p25 p26

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
401.0, 1537.0
30.0, 30.0

Tyk2{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p22 p27

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000148

--

Go back
496.0, 1460.6829268292681
39.14634146341463, 31.317073170731707

STAT2{p}

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26 p27

p28

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
469.5, 1263.608919067719
29.663608001468162, 41.391080932281156

STAT1{p}:STAT2{p}:IRF9

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
622.0, 1385.5
60.0, 13.0

ISG

--

e35

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p29

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
730.0, 1423.5
60.0, 17.0

ISG:ISG3

--

e36

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p29

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
778.0, 1377.5
60.0, 13.0

IFN-alpha

--

e37

cso30:c:Dna

cso30:i:CC_Nucleolus

--

--

p36

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
914.0, 1351.5
60.0, 17.0

IFN-alpha:IRF7{p}

--

e38

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p36

p37

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
810.0, 1396.0
60.0, 32.0

IFN-alpha

--

e39

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
349.4332793662382, 207.5773241621215
940.6735084660947, 1424.8124699339703

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
718.5, 157.31440473580355
27.737557553168166, 53.68559526419645

LPS:TLR4

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

p40 p46

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1191.5, 159.11642183731635
26.289848717386537, 50.88357816268363

flagellin:TLR5

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
805.5, 167.2235272527069
29.939805468893383, 41.776472747293084

LPS:TLR4:MYD88

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

p41

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
929.0, 159.0
29.999999999999996, 50.00000000000001

LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
999.0, 165.58823529411762
26.64705882352942, 44.411764705882355

LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6{ub}

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p43

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
964.0, 294.4198895027625
32.0220994475138, 35.58011049723756

Ubc13:Uev1A

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p42 p58

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
828.5, 374.61791154340244
30.373830060561573, 42.38208845659754

TAK1:TAB1:TAB2

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1150.5, 405.6300238575885
26.06514956872821, 36.36997614241145

TAK1:TAB1:TAB2 {active}

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
910.5, 440.0534042943659
27.911726922371084, 38.946595705634074

dsRNA:TLR3:TRIF

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p47

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
843.5, 606.8531023898269
25.909230431922822, 50.146897610173205

dsRNA:DDX58

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p68 p69

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
521.6545959573893, 1026.222450792907
524.7987662100164, 475.934821497725

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
578.3367718236485, 1037.501414162004
306.86557279319436, 461.2756380840372

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
528.4955482171101, 1032.574763605506
511.1168616905752, 463.2301958725289

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
529.4728271113559, 1033.55204249975
509.1623039020833, 461.2756380840372

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
521.6545959573893, 1026.222450792907
524.7987662100164, 475.934821497725

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
521.6545959573893, 1026.222450792907
524.7987662100164, 475.934821497725

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
529.4728271113559, 1033.55204249975
509.1623039020833, 461.2756380840372

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
904.7479225017586, 1221.6782296420758
32.78654340384294, 29.680449818215777

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
818.7473798081242, 1358.4972748364928
92.84149495335494, 84.04598490514243

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
521.6545959573893, 1026.222450792907
524.7987662100164, 475.934821497725

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
460.0, 812.0
32.0, 32.0

IKK{active}

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2 p5 p63

p6

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
645.3467123136808, 1237.7239527846907
16.61960581508474, 8.002032429485245

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
644.7917366323652, 1213.8599984881087
56.88500733487582, 102.39301320277649

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
668.655690928948, 1280.4570802460128
8.879610901053777, 8.879610901053779

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1031.5, 164.79702697742704
33.11213066617728, 46.202973022572955

LPS:TLR4:TRIF

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
914.0, 588.8235294117646
27.70588235294117, 46.1764705882353

dsRNA:TLR3:TRIF:RIP1:TRAF6

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p48 p49

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
527.0, 983.0
26.0, 26.0

NF-kappaB{active}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48 p68

p9

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
910.0, 644.6764705882352
27.794117647058822, 46.32352941176471

dsRNA:TLR3:TRIF:RIP1:TRAF6:TBK1

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p49

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1214.5, 299.3556073987669
27.476253957673723, 33.64439260123313

MYD88:TRAF3

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
703.0, 397.65745856353595
25.50828729281768, 28.342541436464092

TRIF:TRAF3

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
918.0, 436.9921491286292
195.697001877382, 326.7144861851207

--

e69

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false true false

--

Go back
252.86520698255833, 152.38689226302648
1041.2050183117535, 1475.360616353185

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
918.0, 436.9921491286292
195.697001877382, 326.7144861851207

--

e70

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false true false

--

Go back
918.0, 436.9921491286292
195.697001877382, 326.7144861851207

--

e71

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false true false

--

Go back
1190.0, 738.435321201491
52.38324928743697, 27.0646787985091

ssRNA

--

e72

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p52 p53

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1035.5, 707.2606884455164
25.181977636483225, 48.73931155448367

ssRNA:TLR8

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1097.5, 543.8642841482131
21.253453190089893, 41.13571585178689

ssRNA:TLR7

--

e74

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p53

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1102.0, 777.5
60.0, 13.0

CpG DNA

--

e75

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p54

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
949.5, 740.6928305196228
20.308704231528175, 39.307169480377105

CpG DNA: TLR9

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1084.5, 874.6289227381171
30.36593870434942, 42.37107726188292

MYD88:TRAF6:IRF7

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p56

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1186.0, 971.764705882353
28.94117647058824, 48.235294117647065

MYD88:TRAF6:IRF7:IRAK1

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p58

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1028.0, 976.0294117647059
23.38235294117647, 38.97058823529412

MYD88:TRAF6{ub}:IRF7:IRAK1

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p57

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
256.58501972917304, 178.42558148932886
998.8403808263719, 1450.316232959891

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
823.0, 1447.0
26.0, 26.0

IRF-7{p}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59

p36

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
413.5, 358.37577070488254
28.27645392434594, 34.62422929511748

MAVS:TRAF6

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
561.5, 364.6900348687833
28.17214167737199, 39.309965131216735

FADD:RIP1:MAVS

--

e82

cso30:c:Complex

cso30:i:CC_Extracellular

--

p62

p63

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
387.0, 689.5469613259669
25.607734806629836, 28.453038674033156

MAVS:IKK-alpha

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
520.5, 633.6547242126313
23.14864189301783, 28.34527578736877

MAVS:IKK-i

--

e84

cso30:c:Complex

cso30:i:CC_Extracellular

--

p66

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
775.0, 655.18
33.76, 25.32

NS3/4A

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

p67

p65

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
646.0, 696.3922651933701
27.54696132596685, 30.60773480662983

MAVS:NS3/4A

--

e86

cso30:c:Complex

cso30:i:CC_Extracellular

--

p65

p67

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
556.0, 820.0
32.0, 32.0

IRF-3{active}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

--

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1223.5, 1129.9163149201688
25.859974307212333, 36.083685079831156

MYD88:TRAF6{ub}:IRAK1

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
266.50452038681243, 204.46427071563153
994.2801265895969, 1431.2956989809886

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
845.0, 513.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000066987

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 16474426, 15208624 retinoic acid inducible gene ? I (RIG-I) has been identified as a cytosolic receptor for intracellular dsRNA.

Go back
642.0, 810.0
19.0, 19.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000016608

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1
stoichiometry:c27 : 1

m977*m1599*0.1

nodelay

--

true

0

false

PMID: 16474426, 12692549, 12702806 In response to a viral challenge, IRF3 is phosphorylated by the IKK-like kinases TBK-1 and IKKe.

Go back
725.0, 817.0
21.0, 21.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000019331

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m977*m3902*0.1

nodelay

--

true

0

false

PMID: 16474426, 12692549, 12702806 In response to a viral challenge, IRF3 is phosphorylated by the IKK-like kinases TBK-1 and IKKe.

Go back
646.0, 918.0
20.0, 20.0

p12

p12

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 16474426 Phosphorylation of IRF3 leads to its dimerization and translocation into the nucleus.

Go back
738.0, 978.0
19.0, 19.0

p13

p13

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 16474426 Phosphorylation of IRF3 leads to its dimerization and translocation into the nucleus.

Go back
968.0, 908.0
23.0, 23.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 16474426 Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.

Go back
850.0, 838.0
19.0, 19.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 16474426 Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.

Go back
807.0, 1151.0
17.0, 17.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

MO000055971 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c45 : 1
stoichiometry:c41 : 1

m31298*m25*0.1

nodelay

--

true

0

false

PMID: 16474426 Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.

Go back
853.0, 1151.5
18.5, 18.5

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

MO000055971 e20

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1
stoichiometry:c43 : 1

m31298*m23*0.1

nodelay

--

true

0

false

PMID: 16474426 Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.

Go back
754.0, 1282.0
19.0, 19.0

p18

p18

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e24 e26

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c53 : 1
stoichiometry:c47 : 1

m27*m29*0.1

nodelay

--

true

0

false

PMID: 16474426 Together with the nuclear architectural protein HMG-I (Y), NF-kappaB, IRF3 and ATF2/c-Jun assemble into a stereospecific enhanceosome complex that remodels the chromatin in the promoter of IFN-beta, resulting in its transcriptional initiation.

Go back
686.0, 1182.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000045747 e17 e19 e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m23351*m18*m20*m26*0.1

nodelay

--

true

0

false

PMID: 16474426 Together with the nuclear architectural protein HMG-I (Y), NF-kappaB, IRF3 and ATF2/c-Jun assemble into a stereospecific enhanceosome complex that remodels the chromatin in the promoter of IFN-beta, resulting in its transcriptional initiation.

Go back
465.0, 741.5
20.5, 20.5

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e12

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c12 : 1
stoichiometry:c5 : 1

m207*m12*0.1

nodelay

--

true

0

false

PMID: 16474426 In the presence of diverse stimuli, such as IL-1beta, TNF-alpha, and viruses, the IkappaB kinase (IKK) is activated and it then phosphorylates IkappaB.

Go back
835.0, 1330.5
18.5, 18.5

p20

p20

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e25

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 16474426 Together with the nuclear architectural protein HMG-I (Y), NF-kappaB, IRF3 and ATF2/c-Jun assemble into a stereospecific enhanceosome complex that remodels the chromatin in the promoter of IFN-beta, resulting in its transcriptional initiation.

Go back
165.0, 1253.0
21.0, 21.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e29 MO000016660

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c163 : 1
stoichiometry:c58 : 1

m32*m1636*0.1

nodelay

--

true

0

false

PMID: 16474426, 16214811 IFN-beta binds to the IFNalpha/beta receptor (IFNAR) in autocrine and paracrine manner to initiate a positive feedback loop that results in further production of type I IFNs.

Go back
562.0, 1526.0
19.0, 19.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e31

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m1357*m34*0.1

nodelay

--

true

0

false

PMID: 16474426 These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.

Go back
362.0, 1330.0
19.0, 19.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000145 e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c63 : 1
stoichiometry:c60 : 1

m129*m31*0.1

nodelay

--

true

0

false

PMID: 16474426 IFNARs trigger the activation of the janus kinase (JAK) family members JAK1 and Tyk-2.

Go back
405.0, 1489.0
22.5, 22.5

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000148 e28

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c64 : 1
stoichiometry:c62 : 1

m132*m31*0.1

nodelay

--

true

0

false

PMID: 16474426 IFNARs trigger the activation of the janus kinase (JAK) family members JAK1 and Tyk-2.

Go back
561.0, 1557.5
21.5, 21.5

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

MO000013119 e30

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m1357*m33*0.1

nodelay

--

true

0

false

PMID: 16474426 These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.

Go back
450.0, 1426.0
19.0, 19.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013120 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m1358*m33*0.1

nodelay

--

true

0

false

PMID: 16474426 These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.

Go back
449.0, 1385.0
21.0, 21.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013120 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m1358*m34*0.1

nodelay

--

true

0

false

PMID: 16474426 These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.

Go back
420.0, 1308.0
23.0, 23.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 MO000019704 MO000007758

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c56 : 1
stoichiometry:c80 : 1

m35*m4238*m991*0.1

nodelay

--

true

0

false

PMID: 16474426 These transcription factors associate with IRF9 to form a heterotrimeric complex, IFN-stimulated gene factor 3 (ISGF3).

Go back
717.0, 1381.0
21.0, 21.0

p29

p29

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e35 e34

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m38*m37*0.1

nodelay

--

true

0

false

PMID: 16474426 ISGF3 initiates the transcription of several interferon stimulated genes (ISGs) by binding to the IFN-stimulated response elements (ISRE) in their promoter regions.

Go back
182.0, 710.5
19.5, 19.5

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016597 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m1591*m11*0.1

nodelay

--

true

0

false

Go back
424.0, 1172.0
23.0, 23.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c115 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 16474426 IFN-beta produced in response to a viral challenge by the IRF3 dependent pathway described above, induces transcription of IRF-7.

Go back
1060.0, 1272.0
23.0, 23.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010713

MO000007702

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m93631*0.1

nodelay

--

true

0

false

PMID: 16474426 IFN-beta produced in response to a viral challenge by the IRF3 dependent pathway described above, induces transcription of IRF-7.

Go back
934.0, 1206.0
19.0, 19.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c86 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 16474426 IFN-beta produced in response to a viral challenge by the IRF3 dependent pathway described above, induces transcription of IRF-7.

Go back
1029.0, 1420.0
19.0, 19.0

p33

p33

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000016608

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c95 : 1
stoichiometry:c91 : 1

m980*m1599*0.1

nodelay

--

true

0

false

PMID: 16474426 IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.

Go back
1105.0, 1429.0
21.0, 21.0

p34

p34

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000019331

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1

m980*m3902*0.1

nodelay

--

true

0

false

PMID: 16474426 IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.

Go back
881.0, 557.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 16474426 TLR3 recognizes viral double-stranded RNA, TLR4 recognizes bacterial lipopolysaccharides (LPS), whereas TLR5 is a receptor for bacterial flagellin.

Go back
866.0, 1370.0
19.0, 19.0

p36

p36

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

e37 e80

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c171 : 1
stoichiometry:c97 : 1

m40*m84*0.1

nodelay

--

true

0

false

PMID: 16474426 IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.

Go back
929.0, 1397.0
21.0, 21.0

p37

p37

cso30:i:ME_Transcription

cso30:i:CC_Cytosol

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 16474426 IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.

Go back
666.0, 90.0
19.0, 19.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000016882

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c104 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 16474426 TLR3 recognizes viral double-stranded RNA, TLR4 recognizes bacterial lipopolysaccharides (LPS), whereas TLR5 is a receptor for bacterial flagellin.

Go back
1177.0, 81.0
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022185 MO000019399

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 16474426 TLR3 recognizes viral double-stranded RNA, TLR4 recognizes bacterial lipopolysaccharides (LPS), whereas TLR5 is a receptor for bacterial flagellin.

Go back
170.0, 834.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000289 MO000000205

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m230*m176*0.1

nodelay

--

true

0

false

Go back
754.0, 78.0
19.0, 19.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000016573

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m43*m1572*0.1

nodelay

--

true

0

false

PMID: 16474426 Except for TLR3, all TLRs utilize MyD88 as an adaptor protein to recruit downstream signaling molecules including the protein kinases IRAK4 and IRAK1, and the RING domain ubiquitin ligase TRAF6.

Go back
861.0, 65.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 MO000039077 MO000000212 MO000000213

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c204 : 1
stoichiometry:c117 : 1

m45*m17258*m183*m184*0.1

nodelay

--

true

0

false

PMID: 16474426 Except for TLR3, all TLRs utilize MyD88 as an adaptor protein to recruit downstream signaling molecules including the protein kinases IRAK4 and IRAK1, and the RING domain ubiquitin ligase TRAF6.

Go back
968.0, 76.0
23.0, 23.0

p42

p42

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e44 e46

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c119 : 1

m47*m49*0.1

nodelay

--

true

0

false

PMID: 16474426, 11057907, 11460167 TRAF6 functions together with a dimeric ubiquitin conjugating enzyme complex Ubc13-Uev1A to catalyze the synthesis of Lys63-linked polyubiquitin chains that lead to the activation of a protein kinase complex consisting of TAK1, TAB1 and TAB2.

Go back
1003.0, 395.0
17.0, 17.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e45

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m63*m48*0.1

nodelay

--

true

0

false

PMID: 16474426, 11057907, 11460167 TRAF6 functions together with a dimeric ubiquitin conjugating enzyme complex Ubc13-Uev1A to catalyze the synthesis of Lys63-linked polyubiquitin chains that lead to the activation of a protein kinase complex consisting of TAK1, TAB1 and TAB2.

Go back
1202.0, 594.0
19.0, 19.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000211 e48

MO000038329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c126 : 1
stoichiometry:c125 : 1

m182*m64*0.1

nodelay

--

true

0

false

PMID: 16474426 The activated TAK1 kinase phosphorylates IKKbeta in the activation loop, resulting in the activation of IKK and subsequent nuclear translocation of NF-kappaB.

Go back
1013.0, 537.0
21.0, 21.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 16474426 The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.

Go back
1060.0, 71.5
19.5, 19.5

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 e40

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c130 : 1

m18998*m43*0.1

nodelay

--

true

0

false

PMID: 16474426 The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.

Go back
1039.0, 599.0
25.0, 25.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e49 MO000000212 MO000000065

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c136 : 1
stoichiometry:c135 : 1

m65*m183*m68*0.1

nodelay

--

true

0

false

PMID: 16474426 The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.

Go back
549.0, 1065.0
21.0, 21.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m17*m67*0.1

nodelay

--

true

0

false

PMID: 16474426 The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.

Go back
989.0, 657.0
21.0, 21.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 e64

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m3902*m67*0.1

nodelay

--

true

0

false

PMID: 16474426 TRIF can also bind to TBK1, which phosphorylates and activates IRF3 and IRF7.

Go back
509.0, 737.0
21.0, 21.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e13

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m207*m13*0.1

nodelay

--

true

0

false

PMID: 16474426 In the presence of diverse stimuli, such as IL-1beta, TNF-alpha, and viruses, the IkappaB kinase (IKK) is activated and it then phosphorylates IkappaB.

Go back
1122.0, 306.0
19.0, 19.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000016573

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m1872*m1572*0.1

nodelay

--

true

0

false

PMID: 16474426, 16306937, 16306936 Recent studies have also shown that TRIF and MyD88 can bind to TRAF3.

Go back
706.0, 310.0
19.0, 19.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000016963

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m18998*m1872*0.1

nodelay

--

true

0

false

PMID: 16474426, 16306937, 16306936 Recent studies have also shown that TRIF and MyD88 can bind to TRAF3.

Go back
1142.0, 658.0
19.0, 19.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m19823*m76*0.1

nodelay

--

true

0

false

PMID: 16474426 TLR7 and TLR8 are receptors for G/U-rich ssRNA associated with viruses that enter cells through endocytosis.

Go back
1144.0, 588.0
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e72

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m19940*m76*0.1

nodelay

--

true

0

false

PMID: 16474426 TLR7 and TLR8 are receptors for G/U-rich ssRNA associated with viruses that enter cells through endocytosis.

Go back
1038.0, 774.0
19.0, 19.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m19828*m79*0.1

nodelay

--

true

0

false

PMID: 16474426 TLR9 recognizes unmethylated CpG DNA present in DNA viruses such as herpesvirus.

Go back
608.0, 416.0
23.0, 23.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000212 MO000007702 MO000016573

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c158 : 1
stoichiometry:c161 : 1

m183*m980*m1572*0.1

nodelay

--

true

0

false

PMID: 16474426 It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.

Go back
1189.0, 921.0
21.0, 21.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e77 MO000000213

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c205 : 1
stoichiometry:c164 : 1

m81*m184*0.1

nodelay

--

true

0

false

PMID: 16474426 It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.

Go back
1136.0, 1060.0
23.0, 23.0

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e79

MO000041457 e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c197 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 16474426 It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.

Go back
1126.0, 986.0
19.0, 19.0

p58

p58

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e78 e46

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c169 : 1
stoichiometry:c168 : 1

m82*m49*0.1

nodelay

--

true

0

false

PMID: 16474426, 15361868 TRAF6 appears to induce the phosphorylation of IRF7 through a mechanism that involves Ubc13-catalyzed K63 polyubiquitination.

Go back
940.0, 1516.0
23.0, 23.0

p59

p59

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041457

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c170 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 16474426 It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.

Go back
519.0, 939.0
17.0, 17.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e6

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m14*m6*0.1

nodelay

--

true

0

false

PMID: 16474426 In the presence of diverse stimuli, such as IL-1beta, TNF-alpha, and viruses, the IkappaB kinase (IKK) is activated and it then phosphorylates IkappaB.

Go back
632.0, 592.0
23.0, 23.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 MO000066987

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m68199*m41844*0.1

nodelay

--

true

0

false

PMID: 16474426 MAVS has been shown to interact with RIG-I in over-expression experiments.

Go back
417.0, 497.0
21.0, 21.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 MO000000212

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m68199*m183*0.1

nodelay

--

true

0

false

PMID: 16474426, 16125763, 16153868 MAVS can interact with TRAF6 and both identified TRAF6 binding sites within MAVS.

Go back
484.0, 404.0
23.0, 23.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 MO000016899 MO000000065

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m68199*m1814*m68*0.1

nodelay

--

true

0

false

PMID: 16474426, 16127453 MAVS interacted with RIP-1 and FADD, and proposed that these molecules linked MAVS to IKK activation.

Go back
554.0, 734.0
19.0, 19.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e82

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m207*m86*0.1

nodelay

--

true

0

false

PMID: 16474426, 16127453 MAVS interacted with RIP-1 and FADD, and proposed that these molecules linked MAVS to IKK activation.

Go back
391.0, 627.0
17.0, 17.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000210 MO000094908

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m181*m68199*0.1

nodelay

--

true

0

false

PMID: 16474426 MAVS bound to IKK alpha and IKK-epsilon directly.

Go back
663.0, 658.5
18.5, 18.5

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m68199*m89*0.1

nodelay

--

true

0

false

PMID: 16474426 NS3/4A binds to and co-localizes with MAVS in the mitochondrial membrane, and it can cleave MAVS directly in vitro.

Go back
492.0, 560.0
15.0, 15.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 MO000016608

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m68199*m1599*0.1

nodelay

--

true

0

false

PMID: 16474426 MAVS bound to IKK alpha and IKK-epsilon directly.

Go back
721.0, 701.0
21.0, 21.0

p67

p67

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e86

e85 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c196 : 1
stoichiometry:c195 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 16474426 NS3/4A binds to and co-localizes with MAVS in the mitochondrial membrane, and it can cleave MAVS directly in vitro.

Go back
494.0, 1090.0
19.0, 19.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e5

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c199 : 1

m17*m5*0.1

nodelay

--

true

0

false

PMID: 16474426 Over-expression of the N-terminal region of RIG-I comprising the two CARD domains is sufficient to activate NF-kappaB and IRF3 in the absence of a viral challenge, whereas the full-length RIG-I is activated only in the presence of dsRNA.

Go back
586.0, 762.0
19.0, 19.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e5

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c203 : 1
stoichiometry:c202 : 1

m977*m5*0.1

nodelay

--

true

0

false

PMID: 16474426 Over-expression of the N-terminal region of RIG-I comprising the two CARD domains is sufficient to activate NF-kappaB and IRF3 in the absence of a viral challenge, whereas the full-length RIG-I is activated only in the presence of dsRNA.

Go back
373.0, 989.0
21.0, 21.0

p7

p7

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 16474426 Once phosphorylated, IkappaB is ubiquitinated and subsequently degraded by the proteasome.

Go back
373.0, 1125.0
21.0, 21.0

p8

p8

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e16

MO000019479 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 16474426 Once phosphorylated, IkappaB is ubiquitinated and subsequently degraded by the proteasome.

Go back
590.0, 1030.0
19.0, 19.0

p9

p9

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e65

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 16474426 Free NF-kappaB then translocates into the nucleus and turns on its target genes.

Go back
657.0, 524.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 844.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.9896781549733, 1408.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.6908218931359, 532.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 526.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0, 566.1049392463369

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.0, 109.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.0, 117.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 49.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.0, 51.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1153.0, 111.26050014705055

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1191.0, 104.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
189.0, 850.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
741.0, 104.5894663844041

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 105.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.0, 97.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
830.0, 93.27676604583041

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 93.89684382198068

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
120.93464009521975, 1186.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.3229895931315, 93.65530661372897

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.0, 86.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.0, 106.4699689384164

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 99.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 753.6490164072221

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.0, 107.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.0, 397.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 405.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.0, 210.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1212.4279577709729, 538.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1212.0, 613.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1169.0, 442.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
951.0, 551.0237707010416

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 284.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.0455126623185, 478.23944430734275

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 696.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.589299422362, 91.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.0, 98.99965383669341

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.0, 86.3389862497323

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 477.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
930.0, 265.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 612.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 261.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.0, 1056.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.9402850002907, 1016.7611400011626

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.9711576880163, 630.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
488.88514344942905, 758.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.0, 683.287329699204

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.0, 623.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.0, 668.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1132.0, 333.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 247.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1141.0, 316.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.0, 280.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.9483263839893, 321.9078037748211

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.0, 329.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1096.0, 671.6994371546483

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 760.589725083218

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1163.8827051358348, 683.3371279422537

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.8074888811523, 674.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.0, 611.159575575166

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1162.9812011109732, 618.4237753155609

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1125.3692975529848, 576.8406661402685

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1023.0, 764.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1065.0, 784.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.7336418228921, 765.0471404825303

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.9282873615695, 260.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.888405753617, 258.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.0, 915.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.8877786578834, 445.99179355439696

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 439.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1115.0, 901.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
113.0, 1236.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.0, 942.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 1004.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.3121947846664, 1083.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1153.0, 996.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1059.0, 996.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.0, 330.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
439.0, 948.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.9129848678837, 1472.0262439340422

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.0, 1396.1554175279994

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 604.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.2294230548097, 483.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.2063309876478, 570.0740528189224

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.3332376839457, 525.2725185831542

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0845815361918, 257.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 401.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.0, 434.93442207623343

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 344.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.0, 844.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
505.71966977094314, 265.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.0, 392.9711254108328

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 692.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.7931034482759, 753.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.2665186418611, 404.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
400.0, 580.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.32252025938215, 610.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 644.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.0, 581.2469504755443

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.56892908110547, 525.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.4920113466981, 961.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
503.0, 575.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 608.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 668.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.4090509434968, 677.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.0, 712.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.6860075717943, 722.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.0, 685.7053735814004

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1159.0, 1081.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.0, 1065.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.0, 1016.5609976974653

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
821.0, 486.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 1010.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.811586307396, 649.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 772.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.8718326344709, 781.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0522783763305, 639.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.1516315234784, 93.99856286348289

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.0, 335.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 1078.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
394.0, 1137.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
394.0, 1069.3941549121707

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.0, 1006.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.0, 1049.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.7053735814004, 788.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 829.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.0, 525.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.0, 788.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 534.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.8, 838.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.7721627102651, 832.895649441528

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
670.1214751973158, 906.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 938.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 988.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.0, 997.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.0, 894.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 931.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 777.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 857.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.1738719632737, 696.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
827.8406661402685, 1126.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.0, 1168.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.0, 1126.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0457559976994, 1170.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.009781221511, 969.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
819.5165478253442, 949.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
690.0, 1292.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.0, 1292.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 1166.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 1144.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 762.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.7552116849392, 1155.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.9125061203771, 1194.1799351232141

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.2648867799863, 1200.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 1241.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.9632722328023, 1341.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.9711254108329, 1301.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.2665186418611, 1248.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.90927411784804, 1250.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
186.0, 1270.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.0, 1290.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
105.0, 720.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
372.0, 1349.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
371.0, 1479.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 1512.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
289.0, 1323.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.0, 1337.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
487.0, 1568.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.0, 1568.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 1408.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
487.0, 1541.4382058168303

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 1539.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
209.76857354483045, 703.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 1537.7900126727347

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
424.0, 1374.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.0, 1442.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 1402.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
430.0, 1371.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.0, 1406.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 1413.6988094901815

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
441.79279858428015, 1338.0437687993774

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.7073588344857, 1336.6058946774283

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.0, 725.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.0, 1298.437601569802

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.0, 1392.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 1402.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.0, 1291.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.86470816677735, 1195.1080143360243

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
944.0, 1225.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
289.0, 1219.2256668621962

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
960.0, 1284.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1082.0, 1295.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
118.0, 844.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.3573680591342, 1368.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.0, 1439.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1120.7788826941526, 1372.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.5777087639997, 1450.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
807.0, 857.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.0, 525.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
838.0, 1381.2855322440994

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.0, 1371.0613012044826

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.0, 1528.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.5699763999032, 1369.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back