_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e70
_enti_e53
_enti_e59
_enti_e71
_enti_e69
_enti_e54
_enti_e51
_enti_e52
_enti_e56
_enti_e50
_enti_e61
_enti_e58
_enti_e57
_enti_e60
_enti_e62
g2_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g3
p1_propro_p1
PMID: 16474426, 15208624
retinoic acid inducible gene I (RIG-I) has been identified as a cytosolic receptor for intracellular dsRNA.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 16474426
In the presence of diverse stimuli, such as IL-1beta, TNF-alpha, and viruses, the IkappaB kinase (IKK) is activated and it then phosphorylates IkappaB.
c4 cso30:c:InputProcess connector
c12 cso30:c:InputAssociation connector
c5 cso30:c:OutputProcess connector
p3_propro_p3
c6 cso30:c:InputProcess connector
c7 cso30:c:InputProcess connector
c8 cso30:c:OutputProcess connector
p4_propro_p4
c9 cso30:c:InputProcess connector
c10 cso30:c:InputProcess connector
c11 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 16474426
In the presence of diverse stimuli, such as IL-1beta, TNF-alpha, and viruses, the IkappaB kinase (IKK) is activated and it then phosphorylates IkappaB.
c13 cso30:c:InputProcess connector
c15 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 16474426
In the presence of diverse stimuli, such as IL-1beta, TNF-alpha, and viruses, the IkappaB kinase (IKK) is activated and it then phosphorylates IkappaB.
c16 cso30:c:InputProcess connector
c18 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 16474426
Once phosphorylated, IkappaB is ubiquitinated and subsequently degraded by the proteasome.
c19 cso30:c:InputProcess connector
c20 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 16474426
Once phosphorylated, IkappaB is ubiquitinated and subsequently degraded by the proteasome.
c21 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
c23 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 16474426
Free NF-kappaB then translocates into the nucleus and turns on its target genes.
c24 cso30:c:InputProcess connector
c25 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 16474426, 12692549, 12702806
In response to a viral challenge, IRF3 is phosphorylated by the IKK-like kinases TBK-1 and IKKe.
c26 cso30:c:InputProcess connector
c28 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 16474426, 12692549, 12702806
In response to a viral challenge, IRF3 is phosphorylated by the IKK-like kinases TBK-1 and IKKe.
c29 cso30:c:InputProcess connector
c31 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 16474426
Phosphorylation of IRF3 leads to its dimerization and translocation into the nucleus.
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 16474426
Phosphorylation of IRF3 leads to its dimerization and translocation into the nucleus.
c34 cso30:c:InputProcess connector
c35 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 16474426
Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 16474426
Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 16474426
Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.
c40 cso30:c:InputProcess connector
c45 cso30:c:InputAssociation connector
c41 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 16474426
Viral infection also leads to activation of stress kinases such as JNK and p38 kinase, which phosphorylate ATF2/c-Jun in the nucleus.
c42 cso30:c:InputProcess connector
c44 cso30:c:InputAssociation connector
c43 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 16474426
Together with the nuclear architectural protein HMG-I (Y), NF-kappaB, IRF3 and ATF2/c-Jun assemble into a stereospecific enhanceosome complex that remodels the chromatin in the promoter of IFN-beta, resulting in its transcriptional initiation.
c46 cso30:c:InputProcess connector
c53 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 16474426
Together with the nuclear architectural protein HMG-I (Y), NF-kappaB, IRF3 and ATF2/c-Jun assemble into a stereospecific enhanceosome complex that remodels the chromatin in the promoter of IFN-beta, resulting in its transcriptional initiation.
c48 cso30:c:InputProcess connector
c49 cso30:c:InputProcess connector
c50 cso30:c:InputProcess connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 16474426
Together with the nuclear architectural protein HMG-I (Y), NF-kappaB, IRF3 and ATF2/c-Jun assemble into a stereospecific enhanceosome complex that remodels the chromatin in the promoter of IFN-beta, resulting in its transcriptional initiation.
c55 cso30:c:InputAssociation connector
c54 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 16474426, 16214811
IFN-beta binds to the IFNalpha/beta receptor (IFNAR) in autocrine and paracrine manner to initiate a positive feedback loop that results in further production of type I IFNs.
c57 cso30:c:InputProcess connector
c163 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 16474426
IFNARs trigger the activation of the janus kinase (JAK) family members JAK1 and Tyk-2.
c59 cso30:c:InputProcess connector
c63 cso30:c:InputAssociation connector
c60 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 16474426
IFNARs trigger the activation of the janus kinase (JAK) family members JAK1 and Tyk-2.
c61 cso30:c:InputProcess connector
c64 cso30:c:InputAssociation connector
c62 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 16474426
These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.
c65 cso30:c:InputProcess connector
c67 cso30:c:InputAssociation connector
c66 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 16474426
These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.
c68 cso30:c:InputProcess connector
c70 cso30:c:InputAssociation connector
c69 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 16474426
These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.
c71 cso30:c:InputProcess connector
c73 cso30:c:InputAssociation connector
c72 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 16474426
These kinases in turn phosphorylate and activate the signal transducer and activator of transcription 1 (STAT1) and STAT2 proteins.
c74 cso30:c:InputProcess connector
c76 cso30:c:InputAssociation connector
c75 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 16474426
These transcription factors associate with IRF9 to form a heterotrimeric complex, IFN-stimulated gene factor 3 (ISGF3).
c78 cso30:c:InputProcess connector
c79 cso30:c:InputProcess connector
c56 cso30:c:InputProcess connector
c80 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 16474426
ISGF3 initiates the transcription of several interferon stimulated genes (ISGs) by binding to the IFN-stimulated response elements (ISRE) in their promoter regions.
c81 cso30:c:InputProcess connector
c83 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 16474426
IFN-beta produced in response to a viral challenge by the IRF3 dependent pathway described above, induces transcription of IRF-7.
c84 cso30:c:InputAssociation connector
c115 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 16474426
IFN-beta produced in response to a viral challenge by the IRF3 dependent pathway described above, induces transcription of IRF-7.
c88 cso30:c:InputAssociation connector
c89 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 16474426
IFN-beta produced in response to a viral challenge by the IRF3 dependent pathway described above, induces transcription of IRF-7.
c87 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 16474426
IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.
c90 cso30:c:InputProcess connector
c95 cso30:c:InputAssociation connector
c91 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 16474426
IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.
c92 cso30:c:InputProcess connector
c94 cso30:c:InputAssociation connector
c93 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 16474426
IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.
c96 cso30:c:InputProcess connector
c171 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 16474426
IRF7 is then activated by phosphorylation at certain key residues by TBK-1/IKKe such that it binds and induces the promoter of IFN-alpha gene.
c99 cso30:c:InputAssociation connector
c100 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 16474426
TLR3 recognizes viral double-stranded RNA, TLR4 recognizes bacterial lipopolysaccharides (LPS), whereas TLR5 is a receptor for bacterial flagellin.
c101 cso30:c:InputProcess connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 16474426
TLR3 recognizes viral double-stranded RNA, TLR4 recognizes bacterial lipopolysaccharides (LPS), whereas TLR5 is a receptor for bacterial flagellin.
c105 cso30:c:InputProcess connector
c106 cso30:c:InputProcess connector
c104 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 16474426
Except for TLR3, all TLRs utilize MyD88 as an adaptor protein to recruit downstream signaling molecules including the protein kinases IRAK4 and IRAK1, and the RING domain ubiquitin ligase TRAF6.
c110 cso30:c:InputProcess connector
c111 cso30:c:InputProcess connector
c112 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 16474426
Except for TLR3, all TLRs utilize MyD88 as an adaptor protein to recruit downstream signaling molecules including the protein kinases IRAK4 and IRAK1, and the RING domain ubiquitin ligase TRAF6.
c113 cso30:c:InputProcess connector
c114 cso30:c:InputProcess connector
c116 cso30:c:InputProcess connector
c204 cso30:c:InputProcess connector
c117 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 16474426, 11057907, 11460167
TRAF6 functions together with a dimeric ubiquitin conjugating enzyme complex Ubc13-Uev1A to catalyze the synthesis of Lys63-linked polyubiquitin chains that lead to the activation of a protein kinase complex consisting of TAK1, TAB1 and TAB2.
c118 cso30:c:InputProcess connector
c120 cso30:c:InputAssociation connector
c119 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 16474426, 11057907, 11460167
TRAF6 functions together with a dimeric ubiquitin conjugating enzyme complex Ubc13-Uev1A to catalyze the synthesis of Lys63-linked polyubiquitin chains that lead to the activation of a protein kinase complex consisting of TAK1, TAB1 and TAB2.
c121 cso30:c:InputProcess connector
c123 cso30:c:InputAssociation connector
c122 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 16474426
The activated TAK1 kinase phosphorylates IKKbeta in the activation loop, resulting in the activation of IKK and subsequent nuclear translocation of NF-kappaB.
c124 cso30:c:InputProcess connector
c126 cso30:c:InputAssociation connector
c125 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 16474426
The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.
c127 cso30:c:InputProcess connector
c128 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 16474426
The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.
c131 cso30:c:InputProcess connector
c132 cso30:c:InputProcess connector
c130 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 16474426
The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.
c133 cso30:c:InputProcess connector
c134 cso30:c:InputProcess connector
c136 cso30:c:InputProcess connector
c135 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 16474426
The TIR domains of TLR3 and TLR4 bind to another adaptor protein TRIF, which binds directly to TRAF6 and RIP1 to activate NF-kappaB.
c137 cso30:c:InputProcess connector
c139 cso30:c:InputAssociation connector
c138 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 16474426
TRIF can also bind to TBK1, which phosphorylates and activates IRF3 and IRF7.
c140 cso30:c:InputProcess connector
c141 cso30:c:InputProcess connector
c142 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 16474426, 16306937, 16306936
Recent studies have also shown that TRIF and MyD88 can bind to TRAF3.
c143 cso30:c:InputProcess connector
c144 cso30:c:InputProcess connector
c145 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 16474426, 16306937, 16306936
Recent studies have also shown that TRIF and MyD88 can bind to TRAF3.
c146 cso30:c:InputProcess connector
c147 cso30:c:InputProcess connector
c148 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 16474426
TLR7 and TLR8 are receptors for G/U-rich ssRNA associated with viruses that enter cells through endocytosis.
c149 cso30:c:InputProcess connector
c150 cso30:c:InputProcess connector
c151 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 16474426
TLR7 and TLR8 are receptors for G/U-rich ssRNA associated with viruses that enter cells through endocytosis.
c152 cso30:c:InputProcess connector
c153 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 16474426
TLR9 recognizes unmethylated CpG DNA present in DNA viruses such as herpesvirus.
c155 cso30:c:InputProcess connector
c156 cso30:c:InputProcess connector
c157 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 16474426
It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.
c159 cso30:c:InputProcess connector
c160 cso30:c:InputProcess connector
c158 cso30:c:InputProcess connector
c161 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 16474426
It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.
c162 cso30:c:InputProcess connector
c205 cso30:c:InputProcess connector
c164 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 16474426
It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.
c165 cso30:c:InputProcess connector
c166 cso30:c:OutputProcess connector
c197 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 16474426, 15361868
TRAF6 appears to induce the phosphorylation of IRF7 through a mechanism that involves Ubc13-catalyzed K63 polyubiquitination.
c167 cso30:c:InputProcess connector
c169 cso30:c:InputAssociation connector
c168 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 16474426
It has been shown that MyD88 and TRAF6 can bind to IRF7 directly, and recruit IRAK1 to phosphorylate IRF7, resulting in the nuclear translocation and activation of IRF7.
c98 cso30:c:InputProcess connector
c170 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 16474426
MAVS has been shown to interact with RIG-I in over-expression experiments.
c172 cso30:c:InputProcess connector
c173 cso30:c:InputProcess connector
c174 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 16474426, 16125763, 16153868
MAVS can interact with TRAF6 and both identified TRAF6 binding sites within MAVS.
c175 cso30:c:InputProcess connector
c176 cso30:c:InputProcess connector
c177 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 16474426, 16127453
MAVS interacted with RIP-1 and FADD, and proposed that these molecules linked MAVS to IKK activation.
c178 cso30:c:InputProcess connector
c179 cso30:c:InputProcess connector
c180 cso30:c:InputProcess connector
c181 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 16474426, 16127453
MAVS interacted with RIP-1 and FADD, and proposed that these molecules linked MAVS to IKK activation.
c182 cso30:c:InputProcess connector
c184 cso30:c:InputAssociation connector
c183 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 16474426
MAVS bound to IKK alpha and IKK-epsilon directly.
c185 cso30:c:InputProcess connector
c186 cso30:c:InputProcess connector
c187 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 16474426
NS3/4A binds to and co-localizes with MAVS in the mitochondrial membrane, and it can cleave MAVS directly in vitro.
c191 cso30:c:InputProcess connector
c192 cso30:c:InputProcess connector
c193 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 16474426
MAVS bound to IKK alpha and IKK-epsilon directly.
c188 cso30:c:InputProcess connector
c189 cso30:c:InputProcess connector
c190 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 16474426
NS3/4A binds to and co-localizes with MAVS in the mitochondrial membrane, and it can cleave MAVS directly in vitro.
c194 cso30:c:InputProcess connector
c196 cso30:c:OutputProcess connector
c195 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 16474426
Over-expression of the N-terminal region of RIG-I comprising the two CARD domains is sufficient to activate NF-kappaB and IRF3 in the absence of a viral challenge, whereas the full-length RIG-I is activated only in the presence of dsRNA.
c198 cso30:c:InputProcess connector
c200 cso30:c:InputAssociation connector
c199 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 16474426
Over-expression of the N-terminal region of RIG-I comprising the two CARD domains is sufficient to activate NF-kappaB and IRF3 in the absence of a viral challenge, whereas the full-length RIG-I is activated only in the presence of dsRNA.
c201 cso30:c:InputProcess connector
c203 cso30:c:InputAssociation connector
c202 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 16474426
TLR3 recognizes viral double-stranded RNA, TLR4 recognizes bacterial lipopolysaccharides (LPS), whereas TLR5 is a receptor for bacterial flagellin.
c107 cso30:c:InputProcess connector
c108 cso30:c:InputProcess connector
c109 cso30:c:OutputProcess connector
DDX58_enti_MO000066987
DDX58
dsRNA_enti_MO000022224
dsRNA
dsRNA:DDX58_enti_e5
dsRNA:DDX58
IKK_enti_MO000000248
IKK
IKK{active}_enti_e6
IKK{active}
IL-1beta_enti_MO000016597
IL-1beta
IL-1betaR_enti_e11
IL-1betaR
TNF-alpha_enti_MO000000289
TNF-alpha
TNFR_enti_MO000000205
TNFR
IL-1beta:IL-1betaR_enti_e12
IL-1beta:IL-1betaR
TNF-alpha:TNFR_enti_e13
TNF-alpha:TNFR
NF-kappaB:IkappaB_enti_e14
NF-kappaB:IkappaB
NF-kappaB:IkappaB{p}_enti_e15
NF-kappaB:IkappaB{p}
NF-kappaB:IkappaB{p}{ub}_enti_e16
NF-kappaB:IkappaB{p}{ub}
protein remnants_enti_MO000019479
protein remnants
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB{active}_enti_e17
NF-kappaB{active}
TBK1_enti_MO000019331
TBK1
IKK-i_enti_MO000016608
IKK-i
IRF-3_enti_MO000007694
IRF-3
IRF-3{p}_enti_MO000041456
IRF-3{p}
(IRF-3{p})2_enti_e18
(IRF-3{p})2
(IRF-3{p})2_enti_e19
(IRF-3{p})2
JNK_enti_MO000000023
JNK
JNK{active}_enti_e20
JNK{active}
p38_enti_MO000000022
p38
p38{active}_enti_e22
p38{active}
ATF-2:c-Jun_enti_MO000055971
ATF-2:c-Jun
ATF-2{p}:c-Jun{p}_enti_e23
ATF-2{p}:c-Jun{p}
HMGA1_enti_MO000045747
HMGA1
IFN-beta_enti_e24
IFN-beta
IFN-beta:enhanceosome complex_enti_e25
IFN-beta:enhanceosome complex
enhancesome complex_enti_e26
enhancesome complex
IFN-beta_enti_G010228
IFN-beta
IFN-beta:IFN-betaR_enti_e28
IFN-beta:IFN-betaR
IFN-betaR_enti_e29
IFN-betaR
Jak1_enti_MO000000145
Jak1
Jak1{active}_enti_e30
Jak1{active}
Tyk2_enti_MO000000148
Tyk2
Tyk2{active}_enti_e31
Tyk2{active}
STAT1_enti_MO000013119
STAT1
STAT1{p}_enti_MO000019704
STAT1{p}
STAT2_enti_MO000013120
STAT2
STAT2{p}_enti_e32
STAT2{p}
STAT1{p}:STAT2{p}:IRF9_enti_e34
STAT1{p}:STAT2{p}:IRF9
ISG_enti_e35
ISG
ISG:ISG3_enti_e36
ISG:ISG3
IRF-7_enti_MO000007702
IRF-7
IRF-7_enti_G010713
IRF-7
IRF-7{p}_enti_MO000041457
IRF-7{p}
IFN-alpha_enti_e37
IFN-alpha
IFN-alpha:IRF7{p}_enti_e38
IFN-alpha:IRF7{p}
IFN-alpha_enti_e39
IFN-alpha
TLR3_enti_MO000019398
TLR3
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e40
LPS:TLR4
LPS_enti_MO000016882
LPS
MyD88_enti_MO000016573
MyD88
LPS:TLR4:MYD88_enti_e42
LPS:TLR4:MYD88
IRAK-4_enti_MO000039077
IRAK-4
TRAF6_enti_MO000000212
TRAF6
LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6_enti_e44
LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6
LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6{ub}_enti_e45
LPS:TLR4:MYD88:IRAK1:IRAK4:TRAF6{ub}
Ubc13:Uev1A_enti_e46
Ubc13:Uev1A
TAK1:TAB1:TAB2_enti_e47
TAK1:TAB1:TAB2
TAK1:TAB1:TAB2 {active}_enti_e48
TAK1:TAB1:TAB2 {active}
IKK-beta_enti_MO000000211
IKK-beta
IKK-beta{p}_enti_MO000038329
IKK-beta{p}
TRIF_enti_MO000041125
TRIF
dsRNA:TLR3:TRIF_enti_e49
dsRNA:TLR3:TRIF
LPS:TLR4:TRIF_enti_e63
LPS:TLR4:TRIF
dsRNA:TLR3:TRIF:RIP1:TRAF6_enti_e64
dsRNA:TLR3:TRIF:RIP1:TRAF6
RIP1_enti_MO000000065
RIP1
NF-kappaB{active}_enti_e65
NF-kappaB{active}
dsRNA:TLR3:TRIF:RIP1:TRAF6:TBK1_enti_e66
dsRNA:TLR3:TRIF:RIP1:TRAF6:TBK1
TRAF3_enti_MO000016963
TRAF3
MYD88:TRAF3_enti_e67
MYD88:TRAF3
TRIF:TRAF3_enti_e68
TRIF:TRAF3
TLR8_enti_MO000042007
TLR8
ssRNA_enti_e72
ssRNA
ssRNA:TLR8_enti_e73
ssRNA:TLR8
TLR7_enti_MO000042126
TLR7
ssRNA:TLR7_enti_e74
ssRNA:TLR7
TLR9_enti_MO000042012
TLR9
CpG DNA_enti_e75
CpG DNA
CpG DNA: TLR9_enti_e76
CpG DNA: TLR9
MYD88:TRAF6:IRF7_enti_e77
MYD88:TRAF6:IRF7
MYD88:TRAF6:IRF7:IRAK1_enti_e78
MYD88:TRAF6:IRF7:IRAK1
MYD88:TRAF6{ub}:IRF7:IRAK1_enti_e79
MYD88:TRAF6{ub}:IRF7:IRAK1
IRF-7{p}_enti_e80
IRF-7{p}
MAVS_enti_MO000094908
MAVS
MAVS:DDX58_enti_e21
MAVS:DDX58
MAVS:TRAF6_enti_e81
MAVS:TRAF6
FADD_enti_MO000016899
FADD
FADD:RIP1:MAVS_enti_e82
FADD:RIP1:MAVS
IKK-alpha_enti_MO000000210
IKK-alpha
MAVS:IKK-alpha_enti_e83
MAVS:IKK-alpha
MAVS:IKK-i_enti_e84
MAVS:IKK-i
NS3/4A_enti_e85
NS3/4A
MAVS:NS3/4A_enti_e86
MAVS:NS3/4A
MYD88:TRAF6{ub}:IRAK1_enti_e88
MYD88:TRAF6{ub}:IRAK1
IRF-3{active}_enti_e87
IRF-3{active}
TLR5_enti_MO000019399
TLR5
flagellin_enti_MO000022185
flagellin
flagellin:TLR5_enti_e41
flagellin:TLR5
IRAK(IRAK-1)_enti_MO000000213
IRAK(IRAK-1)
IFNbeta_enti_MO000016660
IFNbeta
ISGF-3gamma(IRF9)_enti_MO000007758
ISGF-3gamma(IRF9)