/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16530484.csml - 2009.07.01.10:54

G027947

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m19*0.1

nodelay

true

false

PMID: 16530484, 14681580 several IFN target genes such as chemokine (C?C motif) ligand 2 (CCL2), interferon-stimulated exonuclease gene 20kDa (ISG20) and 2��?5��oligoadenylate synthetase 1 (OAS1) are induced by chemically synthesized siRNAs

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797.0, 1349.0

21.0, 21.0

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

e21

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c28 : 1

m19*0.1

nodelay

true

false

Go back

1154.0, 510.0

19.0, 19.0

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e22 MO000042126

e23

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m22*m19940*0.1

nodelay

true

false

PMID: 16530484, 12738885 Human and murine TLR7 recognize several synthetic compounds that are mainly derivatives and analogs of guanine; these include imiquimod, R-848, loxoribine and bropirimine.

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1131.0, 683.0

17.0, 17.0

p13

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

MO000042126 e25

e24

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m19940*m25*0.1

nodelay

true

false

PMID: 16530484, 12738885 Human and murine TLR7 recognize several synthetic compounds that are mainly derivatives and analogs of guanine; these include imiquimod, R-848, loxoribine and bropirimine.

Go back

1191.0, 731.0

17.0, 17.0

p14

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

MO000042126 e26

e27

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m19940*m26*0.1

nodelay

true

false

PMID: 16530484, 12738885 Human and murine TLR7 recognize several synthetic compounds that are mainly derivatives and analogs of guanine; these include imiquimod, R-848, loxoribine and bropirimine.

Go back

1178.0, 802.0

19.0, 19.0

p15

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

MO000042126 e29

e28

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c41 : 1
stoichiometry:c40 : 1

m19940*m29*0.1

nodelay

true

false

PMID: 16530484, 12738885 Human and murine TLR7 recognize several synthetic compounds that are mainly derivatives and analogs of guanine; these include imiquimod, R-848, loxoribine and bropirimine.

Go back

1056.0, 499.5

16.5, 16.5

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000016573 e15

e30

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m1572*m15*0.1

nodelay

true

false

PMID: 16530484 The immune effects of TLR7, TLR8 and TLR9 are mediated by the adaptor protein MyD88, which leads to the activation of NF-��B, which then stimulates transcription of proinflammatory-cytokine genes.

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1223.0, 711.0

17.0, 17.0

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e16 MO000016573

e31

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m16*m1572*0.1

nodelay

true

false

Go back

1254.0, 770.0

19.0, 19.0

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000042012 MO000016573

e32

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m19828*m1572*0.1

nodelay

true

false

Go back

1323.0, 666.5

18.5, 18.5

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000041446 MO000041125

e33

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m19314*m18998*0.1

nodelay

true

false

PMID: 16530484 Activation of TLR3 by dsRNA involves Toll/IL-1 receptor (TIR)-domain-containing adaptor inducing IFN-�� (TRIF), which activates IRF3, which is responsible for the induction of IFN-��.

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1678.0, 410.0

19.0, 19.0

cso30:i:ME_Binding

cso30:i:CC_Extracellular

MO000019397 e11

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3964*m11*0.1

nodelay

true

false

PMID: 16530484, 11861602, 15229469 Among bacterial structures that are recognized by TLRs, peptidoglycan, lipopolysaccharide and unmethylated CpG DNA are ligands for TLR2, TLR4 and TLR9, respectively

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1331.0, 839.0

17.0, 17.0

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007694 e33

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m977*m33*0.1

nodelay

true

false

Go back

1167.0, 1447.0

17.0, 17.0

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

G010228

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m34*0.1

nodelay

true

false

Go back

1134.0, 970.0

19.0, 19.0

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000000213 e30

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c60 : 1

m184*m30*0.1

nodelay

true

false

PMID: 16530484 Except for TLR3 (Figure I, yellow), which uses the TIR-domain-containing adaptor-inducing IFN-�� (TRIF) as primary effector protein, all other TLRs use the adaptor protein myeloid differentiation factor-88 (MyD88), which activates a cascade that involves interleukin-1 receptor-associated kinase (IRAK-1), tumour-necrosis-factor receptor-associated factor 6 (TRAF6) and nuclear factor-��B (NF-��B).

Go back

1147.0, 990.5

18.5, 18.5

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000000213 e31

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c64 : 1
stoichiometry:c63 : 1

m184*m31*0.1

nodelay

true

false

PMID: 16530484 Except for TLR3, which uses the TIR-domain-containing adaptor-inducing IFN-�� (TRIF) as primary effector protein, all other TLRs use the adaptor protein myeloid differentiation factor-88 (MyD88), which activates a cascade that involves interleukin-1 receptor-associated kinase (IRAK-1), tumour-necrosis-factor receptor-associated factor 6 (TRAF6) and nuclear factor-��B (NF-��B).

Go back

1106.0, 1006.0

19.0, 19.0

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000000213 e32

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m184*m32*0.1

nodelay

true

false

Go back

1158.0, 1082.0

19.0, 19.0

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000000212 e35

e36

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m183*m36*0.1

nodelay

true

false

Go back

1211.0, 1203.0

17.0, 17.0

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000000058 e36

e37

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m35*m37*0.1

nodelay

true

false

Go back

1423.0, 463.0

17.0, 17.0

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e6 MO000016573

e38

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m6*m1572*0.1

nodelay

true

false

Go back

1430.0, 346.0

19.0, 19.0

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e5 MO000016573

e39

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c78 : 1

m5*m1572*0.1

nodelay

true

false

Go back

1147.0, 1055.0

17.0, 17.0

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000000213 e39

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m184*m40*0.1

nodelay

true

false

Go back

1302.0, 630.0

19.0, 19.0

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000019398 MO000022224

MO000041446

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m3965*m119368*0.1

nodelay

true

false

PMID: 16530484 double-stranded (ds)RNA, CpG DNA, single-stranded (ss)RNA and envelope glycoproteins are recognized by TLR3, TLR9, TLR7 and TLR8, and TLR4, respectively

Go back

1094.0, 1050.0

19.0, 19.0

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000000213 e38

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m184*m39*0.1

nodelay

true

false

Go back

1362.0, 854.0

19.0, 19.0

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007694 e30

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m977*m30*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

1394.0, 870.0

19.0, 19.0

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007694 e31

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c91 : 1
stoichiometry:c90 : 1

m977*m31*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

1428.0, 844.0

15.0, 15.0

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007694 e32

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1

m977*m32*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

1481.0, 872.5

14.5, 14.5

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007694 e39

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c100 : 1
stoichiometry:c98 : 1

m977*m40*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

1451.0, 826.5

18.5, 18.5

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007694 e38

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c99 : 1
stoichiometry:c96 : 1

m977*m39*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

675.0, 963.0

17.0, 17.0

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007702 e39

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c114 : 1
stoichiometry:c104 : 1

m980*m40*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

735.0, 967.0

17.0, 17.0

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007702 e32

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c113 : 1
stoichiometry:c106 : 1

m980*m32*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

787.0, 967.5

17.5, 17.5

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007702 e31

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c112 : 1
stoichiometry:c108 : 1

m980*m31*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

828.0, 944.0

15.0, 15.0

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007702 e30

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c110 : 1

m980*m30*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

1252.0, 580.0

15.0, 15.0

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e12 MO000042012

e13

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m12*m19828*0.1

nodelay

true

false

PMID: 16530484 double-stranded (ds)RNA, CpG DNA, single-stranded (ss)RNA and envelope glycoproteins are recognized by TLR3, TLR9, TLR7 and TLR8, and TLR4, respectively

Go back

636.0, 960.0

15.0, 15.0

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

MO000007702 e38

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c115 : 1
stoichiometry:c102 : 1

m980*m39*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

865.0, 1357.0

21.0, 21.0

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

e20

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m41*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

897.0, 1325.0

21.0, 21.0

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

e20

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m34*0.1

nodelay

true

false

PMID: 16530484 Signalling from TLRs also activate the IFN regulatory factors (IRFs), in particular IRF3 and IRF7, leading to type I IFN production.

Go back

713.0, 1449.0

21.0, 21.0

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

e41

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m41*0.1

nodelay

true

false

PMID: 16530484 This signalling pathway also activates the interferon (IFN) regulatory factor (IRF7), which is responsible for IFN-�� induction.

Go back

1358.0, 582.0

19.0, 19.0

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000022224 MO000066987

e42

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m119368*m41844*0.1

nodelay

true

false

PMID: 16530484 Cytoplasmic dsRNA can activate directly protein kinase R (PKR) and/or the retinoic-acid inducible gene-I (RIG-I), leading to IFN production.

Go back

891.0, 503.0

17.0, 17.0

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e43 MO000022224

e44

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m44*m119368*0.1

nodelay

true

false

PMID: 16530484 Cytoplasmic dsRNA can activate directly protein kinase R (PKR) and/or the retinoic-acid inducible gene-I (RIG-I), leading to IFN production.

Go back

813.0, 581.0

21.0, 21.0

p46

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

e44

e45

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m45*0.1

nodelay

true

false

PMID: 16530484 PKR autophosphorylates in response to dsRNA and subsequently phosphorylates its substrates, one of which is the �� subunit of the eukaryotic translation initiation factor 2 (eIF2-��).

Go back

710.0, 738.0

19.0, 19.0

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

e47 e45

e46

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m48*m46*0.1

nodelay

true

false

Go back

582.0, 846.0

19.0, 19.0

p48

cso30:i:ME_Translation

cso30:i:CC_Cytosol

e46

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1

1.0*0.1

nodelay

true

false

PMID: 16530484 This post-translational modification leads to a general inhibition of protein synthesis.

Go back

513.0, 1553.0

21.0, 21.0

p49

cso30:i:ME_Translation

cso30:i:CC_Cytosol

e41

e48

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m42*0.1

nodelay

true

false

PMID: 16530484 This signalling pathway also activates the interferon (IFN) regulatory factor (IRF7), which is responsible for IFN-�� induction.

Go back

1099.0, 547.0

17.0, 17.0

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000042126 e14

e15

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m19940*m14*0.1

nodelay

true

false

PMID: 16530484 double-stranded (ds)RNA, CpG DNA, single-stranded (ss)RNA and envelope glycoproteins are recognized by TLR3, TLR9, TLR7 and TLR8, and TLR4, respectively

Go back

245.0, 1501.0

21.0, 21.0

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

e48 e63

e49

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m49*m64*0.1

nodelay

true

false

PMID: 16530484 Notably, a large number of IFN target genes, including PKR, are induced via the binding of IFN-�� and IFN-�� to their receptor that is expressed on the cell surface

Go back

654.0, 1617.5

20.5, 20.5

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

e49

e64

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m63*0.1

nodelay

true

false

PMID: 16530484 Notably, a large number of IFN target genes, including PKR, are induced via the binding of IFN-�� and IFN-�� to their receptor that is expressed on the cell surface

Go back

1359.0, 1435.0

17.0, 17.0

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

G010228

e65

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m93217*0.1

nodelay

true

false

Go back

1643.0, 1355.0

17.0, 17.0

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

e67 e65

e66

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m68*m66*0.1

nodelay

true

false

PMID: 16530484 Notably, a large number of IFN target genes, including PKR, are induced via the binding of IFN-�� and IFN-�� to their receptor that is expressed on the cell surface

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753.0, 1685.0

21.0, 21.0

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

e66

e64

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m67*0.1

nodelay

true

false

PMID: 16530484 Notably, a large number of IFN target genes, including PKR, are induced via the binding of IFN-�� and IFN-�� to their receptor that is expressed on the cell surface

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957.0, 609.0

21.0, 21.0

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e19 MO000042126

e68

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m19*m19940*0.1

nodelay

true

false

PMID: 16530484 immunostimulatory siRNA duplexes might bind to endosomal TLR7 and TLR8, but with low affinity compared with that of ssRNAs

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907.0, 867.0

17.0, 17.0

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

e19 MO000042007

e69

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m19*m19823*0.1

nodelay

true

false

PMID: 16530484 immunostimulatory siRNA duplexes might bind to endosomal TLR7 and TLR8, but with low affinity compared with that of ssRNAs

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1136.0, 1380.0

23.0, 23.0

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

e68

G010329

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m69*0.1

nodelay

true

false

PMID: 16530484 when several sequences of siRNA were tested under the same conditions, the (ss) siRNAs showed the highest activity in inducing secretion of tumor necrosis factor (TNF)-�� in human blood cells

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1094.0, 1362.0

19.0, 19.0

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

e69

G010329

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c156 : 1

m70*0.1

nodelay

true

false

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1332.0, 1312.0

15.0, 15.0

p59

cso30:i:ME_Translation

cso30:i:CC_Cytosol

G010329 e68

MO000000289

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c163 : 1
stoichiometry:c160 : 1

m93309*m69*0.1

nodelay

true

false

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1028.0, 616.0

15.0, 15.0

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000042007 e14

e16

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m19823*m14*0.1

nodelay

true

false

PMID: 16530484 double-stranded (ds)RNA, CpG DNA, single-stranded (ss)RNA and envelope glycoproteins are recognized by TLR3, TLR9, TLR7 and TLR8, and TLR4, respectively

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1291.0, 1395.0

17.0, 17.0

p60

cso30:i:ME_Translation

cso30:i:CC_Cytosol

G010329 e69

MO000000289

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m93309*m70*0.1

nodelay

true

false

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1048.0, 1159.5

16.5, 16.5

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

MO000000058 e42

e37

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c166 : 1
stoichiometry:c165 : 1

m35*m43*0.1

nodelay

true

false

PMID: 16530484 In addition to its helicase domain, RIG-I contains a tandem caspase recruitment domain, which transmits signals that lead to NF-��B and IRF3 activation.

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1462.0, 922.0

19.0, 19.0

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

MO000007694 e42

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c169 : 1
stoichiometry:c168 : 1

m977*m43*0.1

nodelay

true

false

PMID: 16530484 In addition to its helicase domain, RIG-I contains a tandem caspase recruitment domain, which transmits signals that lead to NF-��B and IRF3 activation.

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1537.0, 137.0

21.0, 21.0

cso30:i:ME_Binding

cso30:i:CC_Cytosol

MO000019394 e17

e18

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m3961*m17*0.1

nodelay

true

false

PMID: 16530484 double-stranded (ds)RNA, CpG DNA, single-stranded (ss)RNA and envelope glycoproteins are recognized by TLR3, TLR9, TLR7 and TLR8, and TLR4, respectively

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924.0, 1363.0

21.0, 21.0

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

e20

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m19*0.1

nodelay

true

false

PMID: 16530484 Recent studies indicate that they can also trigger several unwanted effects including the induction of type I IFNs

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982.0, 1330.0

19.0, 19.0

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol