1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16698941.csml convertedTime:2009.07.01.10:54

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title New insights into the regulation of TLR signaling.
Authors Miggin SM, O'Neill LA.
Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.miggins@tcd.ie
Abstract Toll-like receptor (TLR) activation is dictated by a number of factors includingthe ligand itself and the localization of the receptor, in terms of expressionprofile and subcellular localization and the signal transduction pathway thathas been activated. Recent work into TLR signal transduction has revealedcomplex regulation at a number of different levels including regulation byphosphorylation, targeted degradation, and sequestration of signaling molecules.Here, we describe recent advances that have been made in our understanding ofhow TLR signaling is regulated at the biochemical level.
PMID 16698941
Model Abstract

Entity

G010228:IFN-beta G011134:IRAK1 MO000000058:NF-kappaB MO000000065:RIP1 MO000000212:TRAF6 MO000000213:IRAK MO000000218:26S proteasome MO000000248:IKK MO000001935:Btk MO000007694:IRF-3 MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016591:A20 MO000016608:IKK-i MO000016882:LPS MO000016900:Caspase-8 MO000016962:TRAF1 MO000016963:TRAF3 MO000017004:SOCS-1 MO000017072:beta-arrestin MO000018839:Mdm2 MO000019331:TBK1 MO000019394:TLR4 MO000019398:TLR3 MO000019399:TLR5 MO000019406:Tollip MO000019479:protein remnants MO000022125:TAB2 MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041541:TAB3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042130:TLR11 e1: e10: e100:R848 e101:beta-arrestin:TRAF6 e102:IL-1beta e103:src kinase e104:src kinase:beta arrestin e105:Mdm2:beta-arrestin e106:IRAK1{p}:(TRAF6)n e107:TRAF1:TRIF e108:TRAF1(1?163) e109:TRAF1(164?416) e11:diacyl lipopreteins:TLR6:TLR2 e110:Mal:TRAF1 e111:MYD88:TRAF1 e112:TRAF3:IRAK e113:TRAF3:TRIF e114:TRAF3:TBK1 e115:IKK-i:TRAF3 e116:PKR e117:PKR:TRAF3 e118:type I IFN e119:ST2L e12:diacyl lipoproteins e120:ST2L:TIRAP e121:ST2L:MYD88 e122:Fliih e123:MYD88:Fliih e124:MYD88s e125:MYD88:MYD88s e126:MYD88:MYD88s:IRAK e13:TLR2:TLR1 e14:triacyl lipoprotein:TLR1:TLR2 e15:triacyl lipoprotein e16: e17: e18: e19:imidazoquinoline-like molecule e2: e20:imidazoquinoline-like molecule:TLR7 e21:ssRNA:TLR7 e22:ssRNA e23:loxoribine:TLR7 e24:loxoribine e25:imidazoquinoline e26:imidazoquinoline:TLR8 e27:ssRNA:TLR8 e28:CpG DNA e29:CpG DNA:TLR9 e3: e30:flagellin:TLR5 e31:profilin-like protein e32:profilin like protein:TLR11 e33:IFN-alpha e34:RIG-1 e35:dsRNA:RIG-1 e36:type I IFNs e37:LPS:TLR4:TRIAD3A e38:Triad3A e39:CpG DNA:TLR9:TRIAD3A e4: e40:LPS:TLR4{ub} e41:LPS:TLR4{ub} e42:TGF-beta e43:TLR4 e44:NF-kappaB{active} e45:LPS:TLR4:TIRAP e46:LPS:TLR4:TIRAP:MYD88 e47:TLR1:TLR2:TIRAP e48:TLR1:TLR2:TIRAP:MYD88 e49:TLR2:TLR6:TIRAP e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR2:TLR6 e60: e61: e62: e63:TLR2:TLR6:TIRAP:MYD88 e64:dsRNA:TLR3:TRIF e65:LPS:TLR4:TRAM e66:LPS:TLR4:TRAM:TRIF e67:LPS:TLR4:TIRAP:MYD88:IRAK4 e68:LPS:TLR4:TIRAP:IRAK4:IRAK e69:LPS:TLR4:TIRAP:IRAK4:IRAK:Tollip e7: e70:LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip:TRAF6 e71:LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip:TRAF6 e72:LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip:TRAF6 e73:LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip{p}:TRAF6 e74:IRAK{p}:TRAF6 e75:IRAK1{p}:TRAF6{ub}n e76:TAK1:TAB1:TAB2:TAB3 e77:TAK1:TAB1:TAB2:TAB3{active} e78:IKK{active} e79:IkappaB:NF-kappaB e8: e80:IkappaB:NF-kappaB e81:NF-kappaB{active} e82:LPS:TLR4:TRAM:TRIF:TBK1:IKK-i e83:{IRF-3(p)}2 e84:{IRF-3(p)}2 e85:DNA:{IRF-3(p)}2 e86:type I IFN DNA e87:LPS:TLR4:TRAM:TRIF:RIP1:TRAF6 e88:Mal:TRAF6 e89:dsRNA:TLR3:TRIF:TRAF6 e9: e90:TIRAP{p} e91:TRAM{p} e92:MYD88{p} e93:TRIF{p} e94:socs-1:Mal{p} e95:Socs-1:TIRAP{p}{ub} e96:IRAK2c e97:IRAK1c e98:IRAK2 e99:IRAK1c:IRAK2:MYD88:TRAF6:Tollip

Process

p1 p10 p100 p101 p102 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
810.0, 1310.0
36.0, 36.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13 p14 p15 p16 p17

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
961.0, 1597.0
38.0, 38.0

IRAK1

--

G011134

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p80

p81

true true true true

csml-variable:Double

m94019

10

false

infinite

0

unit false false false
TRANSFACG011134

--

Go back
1089.5, 945.5
21.0, 21.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34 p65 p68

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1063.0, 707.0
34.0, 34.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1119.0, 843.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p64 p66 p67 p79 p83 p84

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1269.0, 709.0
30.0, 30.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

p81

p45 p92 p102

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
353.0, 345.0
30.0, 30.0

26S proteasome

--

MO000000218

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m189

10

false

infinite

0

unit false false false
TRANSPATHMO000000218

--

Go back
936.0, 980.0
32.0, 32.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
521.5, 273.5
29.0, 29.0

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69 p73

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
353.0, 409.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1172.0, 408.0
24.0, 24.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p38 p40 p71 p77 p79 p91 p99 p100 p101

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1264.5, 1228.5
23.0, 23.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1179.0, 1207.0
26.0, 26.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
1271.0, 1523.0
26.0, 26.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p82

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
1093.0, 605.0
38.0, 38.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p95

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1519.0, 283.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
637.0, 1057.0
30.0, 30.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p89

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
494.0, 1058.0
36.0, 36.0

TRAF1

--

MO000016962

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88 p89 p90 p91

true true true true

csml-variable:Double

m1871

10

false

infinite

0

unit false false false
InterProIPR002083
TRANSPATHMO000016962

--

Go back
403.0, 639.0
34.0, 34.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p92 p93 p94 p95 p96

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
516.0, 492.0
32.0, 32.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

p74

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
1189.0, 1753.0
38.0, 38.0

beta-arrestin

--

MO000017072

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p83 p84 p85 p86 p87

true true true true

csml-variable:Double

m1964

10

false

infinite

0

unit false false false
TRANSPATHMO000017072

--

Go back
558.0, 1746.0
36.0, 36.0

Mdm2

--

MO000018839

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m3461

10

false

infinite

0

unit false false false
InterProIPR001876
TRANSPATHMO000018839

--

Go back
1105.0, 425.0
38.0, 38.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p94

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1317.0, 233.0
30.0, 30.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
757.0, 565.0
30.0, 30.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
569.0, 741.0
30.0, 30.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1261.0, 769.0
30.0, 30.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

p46 p49 p79

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
1024.0, 528.0
24.0, 24.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28 p30 p58 p76 p77

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1129.5, 1201.5
29.0, 29.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
459.0, 655.0
26.0, 26.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
855.0, 475.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p23

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1212.0, 308.0
32.0, 32.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p37 p39 p66 p69 p73 p90 p98

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1269.0, 621.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1262.0, 554.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p43 p72 p88 p93

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1194.0, 446.0
28.0, 28.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42 p70

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
791.5, 599.5
25.0, 25.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p13 p18 p41

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
352.0, 580.0
32.0, 32.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

p61

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
1090.0, 1334.0
36.0, 36.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
820.0, 856.0
24.0, 24.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
563.0, 595.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
815.0, 647.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p5 p6

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
564.0, 864.0
24.0, 24.0

TLR11

--

MO000042130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m19944

10

false

infinite

0

unit false false false
TRANSPATHMO000042130

--

Go back
230.9961735177456, 188.31609457450105
1163.423663035052, 1689.2911587268945

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
242.20567950456024, 214.13612771871814
1127.7138006150678, 1586.3762217453566

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1434.793944491169, 1481.7165685449959
50.4121110176619, 28.56686291000841

R848

--

e100

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p80 p81

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1256.9309281786368, 1705.5480753207798
30.138143642726213, 36.903849358440254

beta-arrestin:TRAF6

--

e101

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83 p84

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
1150.9233246125982, 1935.0027168444356
42.15335077480379, 25.994566311129002

IL-1beta

--

e102

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p84

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
939.567662565905, 1725.3189806678383
32.86467486818981, 21.362038664323375

src kinase

--

e103

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p85

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1011.8541076487252, 1757.127478753541
24.291784702549574, 29.74504249291785

src kinase:beta arrestin

--

e104

cso30:c:Complex

cso30:i:CC_Extracellular

--

p85

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
470.40055248618785, 1672.889502762431
27.19889502762431, 30.220994475138124

Mdm2:beta-arrestin

--

e105

cso30:c:Complex

cso30:i:CC_Extracellular

--

p86

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1154.2762430939226, 780.7513812154696
27.447513812154696, 30.497237569060772

IRAK1{p}:(TRAF6)n

--

e106

cso30:c:Complex

cso30:i:CC_Extracellular

--

p82 p87

p52

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
443.4447513812155, 854.0497237569061
25.11049723756906, 27.90055248618785

TRAF1:TRIF

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
458.212014489837, 1228.1275910646004
19.575971020326023, 31.744817870798954

TRAF1(1?163)

--

e108

cso30:c:Protein

cso30:i:CC_Cytosol

--

p89

p68

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
656.8, 1128.6
30.4, 22.800000000000004

TRAF1(164?416)

--

e109

cso30:c:Protein

cso30:i:CC_Cytosol

--

p89

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1223.6342448155624, 206.7454578821802
24.73151036887503, 34.50908423563957

diacyl lipopreteins:TLR6:TLR2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p39

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
548.5757373771038, 1053.1131478086986
30.84852524579237, 37.7737043826029

Mal:TRAF1

--

e110

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
379.37016574585635, 1269.9668508287293
25.25966850828729, 28.066298342541437

MYD88:TRAF1

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

p91

--

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
372.556323946009, 777.9873354440927
22.887352107982004, 28.025329111814706

TRAF3:IRAK

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

p92

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
322.0, 944.6132596685084
27.34806629834254, 30.386740331491705

TRAF3:TRIF

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p93

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
387.0, 901.8287292817679
26.254143646408842, 29.171270718232048

TRAF3:TBK1

--

e114

cso30:c:Complex

cso30:i:CC_Extracellular

--

p94

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
432.0, 782.756906077348
23.618784530386744, 26.24309392265194

IKK-i:TRAF3

--

e115

cso30:c:Complex

cso30:i:CC_Extracellular

--

p95

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
324.0, 1064.3222982491448
39.20708392030589, 24.177701750855302

PKR

--

e116

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p96

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
427.5, 1324.9650058323614
24.52857857023829, 30.03499416763873

PKR:TRAF3

--

e117

cso30:c:Complex

cso30:i:CC_Extracellular

--

p96

--

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
606.0, 1528.0
60.0, 32.0

type I IFN

--

e118

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p97

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
421.5, 211.9903401086738
29.605956932984505, 48.00965989132623

ST2L

--

e119

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p98 p99

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
1204.477762125176, 14.427953310525258
31.044475749647816, 19.144093378949485

diacyl lipoproteins

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
521.0, 214.69060773480663
30.87845303867403, 34.30939226519336

ST2L:TIRAP

--

e120

cso30:c:Complex

cso30:i:CC_Extracellular

--

p98

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
621.0, 218.6243093922652
38.13812154696132, 42.3756906077348

ST2L:MYD88

--

e121

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p99

--

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
502.0, 330.62000000000006
35.84, 26.880000000000006

Fliih

--

e122

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p100

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
374.0, 292.28729281767954
28.541436464088406, 31.712707182320443

MYD88:Fliih

--

e123

cso30:c:Complex

cso30:i:CC_Extracellular

--

p100

--

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
389.0, 1445.54
37.279999999999994, 27.959999999999997

MYD88s

--

e124

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p47 p101

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
361.0, 1611.1325966850827
30.480662983425415, 33.86740331491713

MYD88:MYD88s

--

e125

cso30:c:Complex

cso30:i:CC_Cytosol

--

p101

p102

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
333.5, 1447.7190310148653
29.584694439346663, 41.28096898513489

MYD88:MYD88s:IRAK

--

e126

cso30:c:Complex

cso30:i:CC_Cytosol

--

p102

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
1081.4309392265193, 203.8121546961326
29.13812154696133, 32.37569060773481

TLR2:TLR1

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1039.9498990640484, 203.18590567076527
24.1002018719031, 33.62818865846945

triacyl lipoprotein:TLR1:TLR2

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p37 p73

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
968.016099818877, 39.676594888307505
39.967800362245924, 24.64681022338499

triacyl lipoprotein

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
567.0, 532.6679119337036
284.15504522784573, 474.39443991428465

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
567.0, 532.6679119337036
284.15504522784573, 474.39443991428465

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
567.0, 532.6679119337036
284.15504522784573, 474.39443991428465

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
954.0, 639.0
60.0, 34.0

imidazoquinoline-like molecule

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
230.9961735177456, 188.31609457450105
1163.423663035052, 1689.2911587268945

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
830.2636483227362, 685.1554483665863
19.472703354527514, 37.68910326682746

imidazoquinoline-like molecule:TLR7

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
833.0912080684061, 738.8862091646569
21.817583863187895, 42.227581670686256

ssRNA:TLR7

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p16 p22

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
945.0502082876562, 718.2092742819557
37.89958342468757, 19.581451436088578

ssRNA

--

e22

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p6 p9

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
832.9450778338083, 790.6033764525323
22.10984433238325, 42.79324709493531

loxoribine:TLR7

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
995.7014297729185, 780.4974768713205
40.59714045416315, 23.005046257359123

loxoribine

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1001.3423044575273, 863.1606391925989
45.31539108494534, 25.678721614802352

imidazoquinoline

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
799.0248848936636, 890.6288094716072
17.950230212672658, 34.74238105678579

imidazoquinoline:TLR8

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
762.9331286998465, 930.4512168384126
18.13374260030695, 35.09756632317474

ssRNA:TLR8

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p14 p20

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
491.189705492173, 550.6244361899708
49.62058901565402, 10.751127620058371

CpG DNA

--

e28

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
566.2976320982241, 657.2212234159175
19.40473580355185, 37.55755316816489

CpG DNA:TLR9

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p17 p19 p26 p34

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
254.2646467784465, 211.58456783520217
1116.8867165136512, 1642.7542122054936

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
574.1447051085288, 800.9252356939268
19.71058978294234, 38.149528612146455

flagellin:TLR5

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
470.71483195814045, 817.3408130408533
34.570336083719056, 21.318373918293414

profilin-like protein

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
563.0384784038588, 918.6551194913396
17.923043192282396, 34.68976101732076

profilin like protein:TLR11

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
940.3546712802768, 1469.522491349481
39.29065743944637, 20.955017301038062

IFN-alpha

--

e33

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18 p19 p20 p21 p22

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
847.36, 386.52
25.279999999999998, 18.96

RIG-1

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
718.267046700285, 345.1620258715194
19.46590659942995, 37.6759482569612

dsRNA:RIG-1

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
531.7058823529412, 1409.1764705882354
40.58823529411765, 21.647058823529417

type I IFNs

--

e36

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
958.5807487612406, 197.27546338777756
26.838502477518823, 37.44907322444486

LPS:TLR4:TRIAD3A

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p27

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
878.4800764741397, 280.56228617428053
19.039847051720667, 30.87542765143893

Triad3A

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27 p29

p25 p26 p33 p34

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
582.629014498073, 546.924206276381
18.741971003853916, 26.151587447238022

CpG DNA:TLR9:TRIAD3A

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p29

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
297.311322310744, 252.30439604142856
1030.793365449057, 1561.3145557930382

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
952.0769769069279, 468.7256822953114
39.846046186144164, 30.548635409377184

LPS:TLR4{ub}

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
572.0769769069279, 376.7256822953114
39.846046186144164, 30.548635409377184

LPS:TLR4{ub}

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

p30

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
894.2408793264733, 1929.4789522918616
19.51824134705332, 45.042095416276894

TGF-beta

--

e42

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p31 p32 p77

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
727.4982698961937, 1561.0657439446368
41.003460207612456, 21.868512110726645

TLR4

--

e43

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p31

p32

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1073.5, 1129.5
21.0, 21.0

NF-kappaB{active}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p34 p58 p65 p68

p57

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1332.3839236557167, 359.79152138006975
23.23215268856671, 32.41695723986052

LPS:TLR4:TIRAP

--

e45

cso30:c:Complex

cso30:i:CC_Extracellular

--

p35

p36

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1326.7205882352941, 421.86764705882354
26.558823529411768, 44.26470588235294

LPS:TLR4:TIRAP:MYD88

--

e46

cso30:c:Complex

cso30:i:CC_Extracellular

--

p36

p44

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1117.5, 202.5
20.999999999999996, 35.0

TLR1:TLR2:TIRAP

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1164.9705882352941, 205.61764705882354
22.058823529411764, 36.76470588235294

TLR1:TLR2:TIRAP:MYD88

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
887.9117647058823, 203.85294117647058
24.17647058823529, 40.294117647058826

TLR2:TLR6:TIRAP

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1318.2466564349922, 277.12256084192063
19.506687130015347, 37.75487831615875

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p15 p21 p25 p33 p35 p42 p69 p78 p83

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
477.2656232280739, 1162.5282706031799
632.6917888913673, 573.7819389014822

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
545.6010492163405, 1176.1260684074114
369.95385793647915, 556.1089839045163

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
485.51300222665793, 1170.186551101865
616.1970308942001, 558.4653779041115

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
486.6911992264552, 1171.3647481016626
613.840636894604, 556.1089839045163

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
477.2656232280739, 1162.5282706031799
632.6917888913673, 573.7819389014822

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
477.2656232280739, 1162.5282706031799
632.6917888913673, 573.7819389014822

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
486.6911992264552, 1171.3647481016626
613.840636894604, 556.1089839045163

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
939.1188471487749, 1398.1676705627212
39.52710664232105, 35.782433381469595

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
835.4375111665763, 1563.1152505343985
111.92871498078185, 101.3249419826026

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
477.2656232280739, 1162.5282706031799
632.6917888913673, 573.7819389014822

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1271.6418096983837, 208.86752207965338
24.71638060323279, 30.26495584069322

TLR2:TLR6

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
626.3875179581065, 1417.5122230518064
20.036419311259113, 9.647164853569206

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
625.7184452025841, 1388.7420945643382
68.57995744105503, 123.44392339389897

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
654.4885736900513, 1469.0308252270374
10.7051640883598, 10.705164088359808

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
831.2941176470588, 214.8235294117647
25.411764705882355, 42.352941176470594

TLR2:TLR6:TIRAP:MYD88

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
720.2616076344283, 531.6208478619931
23.47678473114333, 32.758304276013945

dsRNA:TLR3:TRIF

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p67

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1331.3146448889704, 506.29950449623783
25.370710222059092, 35.40099100752432

LPS:TLR4:TRAM

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p43

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1331.3382352941176, 590.8970588235294
25.32352941176471, 42.20588235294118

LPS:TLR4:TRAM:TRIF

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p59 p64

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1328.264705882353, 656.4411764705883
23.470588235294116, 39.117647058823536

LPS:TLR4:TIRAP:MYD88:IRAK4

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44 p51

p45

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1328.9705882352941, 745.6176470588235
22.058823529411768, 36.76470588235295

LPS:TLR4:TIRAP:IRAK4:IRAK

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1329.4117647058824, 810.3529411764706
21.176470588235297, 35.29411764705883

LPS:TLR4:TIRAP:IRAK4:IRAK:Tollip

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p48

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
246.28186349976596, 195.11393574109272
1140.9561503418308, 1616.705393842298

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1327.9117647058824, 879.8529411764706
24.17647058823529, 40.294117647058826

LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip:TRAF6

--

e70

cso30:c:Complex

cso30:i:CC_Extracellular

--

p48

p47

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1324.5735294117646, 936.9558823529412
22.85294117647059, 38.088235294117645

LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip:TRAF6

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p49

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1327.4264705882354, 987.0441176470588
25.147058823529413, 41.911764705882355

LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip:TRAF6

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

p50

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1330.5882352941176, 1057.6470588235295
26.823529411764707, 44.705882352941174

LPS:TLR4:TIRAP:IRAK4:IRAK{p}:Tollip{p}:TRAF6

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1236.53591160221, 1114.8176795580112
30.92817679558011, 34.364640883977906

IRAK{p}:TRAF6

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p87

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1198.3011049723757, 1172.779005524862
27.397790055248617, 30.441988950276244

IRAK1{p}:TRAF6{ub}n

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p54 p82

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1099.7794117647059, 1215.6323529411766
24.441176470588232, 40.73529411764706

TAK1:TAB1:TAB2:TAB3

--

e76

cso30:c:Complex

cso30:i:CC_Extracellular

--

p53

p54

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1143.735294117647, 1035.5588235294117
24.52941176470588, 40.88235294117647

TAK1:TAB1:TAB2:TAB3{active}

--

e77

cso30:c:Complex

cso30:i:CC_Extracellular

--

p54

p55

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
856.0, 1044.0
32.0, 32.0

IKK{active}

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p56

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
952.4215964005999, 1161.8223629395102
23.156807198800195, 28.355274120979832

IkappaB:NF-kappaB

--

e79

cso30:c:Complex

cso30:i:CC_Extracellular

--

p56

p58

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
250.35804749497134, 223.64722370753074
1094.5328303944088, 1589.2616697326807

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
976.4215964005999, 1101.8223629395102
23.156807198800195, 28.355274120979832

IkappaB:NF-kappaB

--

e80

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p56

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
998.0, 1298.0
28.0, 28.0

NF-kappaB{active}

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
761.1470588235294, 213.91176470588235
21.705882352941174, 36.1764705882353

LPS:TLR4:TRAM:TRIF:TBK1:IKK-i

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p60

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
347.04696132596683, 805.6077348066299
25.906077348066297, 28.784530386740336

{IRF-3(p)}2

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

p62

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
615.0469613259669, 1361.6077348066299
25.906077348066297, 28.784530386740336

{IRF-3(p)}2

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

p63

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
714.0, 1367.5
60.0, 17.0

DNA:{IRF-3(p)}2

--

e85

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p63

p97

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
606.0, 1445.5
60.0, 13.0

type I IFN DNA

--

e86

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p63

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1323.5588235294117, 1187.264705882353
24.88235294117647, 41.47058823529412

LPS:TLR4:TRAM:TRIF:RIP1:TRAF6

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1004.585635359116, 406.8729281767956
30.828729281767952, 34.25414364640884

Mal:TRAF6

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
669.0147058823529, 517.6911764705883
21.970588235294116, 36.617647058823536

dsRNA:TLR3:TRIF:TRAF6

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p68

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
261.22787148218566, 252.1805116739688
1089.5356876347557, 1568.418901167078

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1020.8536585365854, 372.6829268292683
38.29268292682927, 30.634146341463413

TIRAP{p}

--

e90

cso30:c:Protein

cso30:i:CC_Cytosol

--

p69 p73

p74

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1145.5243902439024, 469.2195121951219
36.95121951219513, 29.560975609756103

TRAM{p}

--

e91

cso30:c:Protein

cso30:i:CC_Cytosol

--

p70

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
749.5853658536586, 281.2682926829268
36.829268292682926, 29.463414634146343

MYD88{p}

--

e92

cso30:c:Protein

cso30:i:CC_Extracellular

--

p71

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
980.6951219512196, 563.7560975609756
30.609756097560975, 24.487804878048777

TRIF{p}

--

e93

cso30:c:Protein

cso30:i:CC_Cytosol

--

p72

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
425.7044198895028, 320.1160220994475
28.59116022099448, 31.76795580110498

socs-1:Mal{p}

--

e94

cso30:c:Complex

cso30:i:CC_Extracellular

--

p74

p75

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
416.53867403314916, 495.2651933701657
22.922651933701655, 25.469613259668513

Socs-1:TIRAP{p}{ub}

--

e95

cso30:c:Complex

cso30:i:CC_Extracellular

--

p75

p76

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
818.0190311418685, 1520.2768166089966
43.96193771626298, 23.44636678200692

IRAK2c

--

e96

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p78

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1177.8395696913003, 1436.55285313377
20.32086061739944, 46.89429373246025

IRAK1c

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p79

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1240.745119742403, 1541.7488428255183
22.509760515194206, 36.50231434896357

IRAK2

--

e98

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p79

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1161.7205882352941, 1622.8676470588234
20.558823529411764, 34.264705882352935

IRAK1c:IRAK2:MYD88:TRAF6:Tollip

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1430.5, 286.5
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000016882

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 16698941 lipopolysaccharides (LPS) from Gram-negative bacteria are recognized by TLR4.

Go back
506.75, 598.75
18.5, 18.5

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m19828*m28*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR9 recognizes bacterial and viral CpG DNA motifs.

Go back
377.0, 130.0
21.0, 21.0

p100

p100

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e122 MO000016573

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c289 : 1
stoichiometry:c290 : 1
stoichiometry:c291 : 1

m124*m1572*0.1

nodelay

--

true

0

false

PMID: 16698941, 16424162 Another molecule, Fliih, has been shown to modulate TLR signaling by interacting with MyD88 and acting as a negative regulator.

Go back
446.0, 1554.0
27.0, 27.0

p101

p101

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e124 MO000016573

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1
stoichiometry:c295 : 1

m126*m1572*0.1

nodelay

--

true

0

false

PMID: 16698941 overexpression of MyD88s favors formation of MyD88s-MyD88 heterodimers over MyD88 homodimers.

Go back
349.0, 1529.0
21.0, 21.0

p102

p102

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e125 MO000000213

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c296 : 1
stoichiometry:c297 : 1
stoichiometry:c298 : 1

m127*m184*0.1

nodelay

--

true

0

false

PMID: 16698941 In the presence of these heterodimers, IRAK1 is recruited via the death domain (DD), but it is no longer phosphorylated.

Go back
507.5, 711.5
17.0, 17.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022185 MO000019399

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 16698941, 15001781 TLR5 recognizes flagellin, and human TLR11 recognizes uropathogenic Escherichia coli.

Go back
480.5, 896.5
15.0, 15.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042130 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m19944*m31*0.1

nodelay

--

true

0

false

PMID: 16698941, 16111920, 15860593 The first defined ligand for TLR11 has been described in mice as a profilin-like protein, a class of actin-binding proteins present in apicomplexan protozoa.

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816.5, 1208.5
23.0, 23.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041446

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c37 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
727.5, 1207.5
17.0, 17.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e27

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c39 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
898.5, 1214.5
19.0, 19.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c38 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
664.5, 1232.5
15.0, 15.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c40 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
614.5, 1290.5
19.0, 19.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
870.5, 1398.5
19.0, 19.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041446

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c47 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
910.5, 1334.5
19.0, 19.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c48 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
1209.5, 85.5
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m12*m6*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR2, in combination with TLR1 or TLR6, recognizes triacyl lipopeptides and diacyl lipopeptides, respectively

Go back
986.5, 1362.5
19.0, 19.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e27

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c50 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
1012.5, 1416.5
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c51 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
965.5, 1305.5
21.0, 21.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c49 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 16698941 In addition, antiviral type I interferons (IFNs; IFN-? and multiple IFN-{alpha}) are induced by TLR3, -4, -7, -8, and -9.

Go back
765.5, 433.5
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m119368*m34*0.1

nodelay

--

true

0

false

PMID: 16698941, 16474426, 15208624 viral-derived dsRNA may also be recognized by the cytosolic RNA helicase retinoic acid-inducible gene-I, inducing type I IFN in a TLR-independent manner.

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551.5, 1347.5
17.0, 17.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c60 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 16698941, 16474426, 15208624 viral-derived dsRNA may also be recognized by the cytosolic RNA helicase retinoic acid-inducible gene-I, inducing type I IFN in a TLR-independent manner.

Go back
925.5, 285.5
21.0, 21.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e38

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c64 : 1
stoichiometry:c63 : 1

m5*m38*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 TRIAD3A was a molecule found to bind the cytoplasmic domain of TLR4 and TLR9, but not TLR2, and to promote the ubiquitination and degradation of TLR4 and TLR9, but not TLR2.

Go back
662.5, 438.5
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m29*m38*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 TRIAD3A was a molecule found to bind the cytoplasmic domain of TLR4 and TLR9, but not TLR2, and to promote the ubiquitination and degradation of TLR4 and TLR9, but not TLR2.

Go back
961.5, 381.5
21.0, 21.0

p27

p27

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e37

e40 e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 TRIAD3A was a molecule found to bind the cytoplasmic domain of TLR4 and TLR9, but not TLR2, and to promote the ubiquitination and degradation of TLR4 and TLR9, but not TLR2.

Go back
1028.25, 480.25
15.5, 15.5

p28

p28

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e40

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 TRIAD3A was a molecule found to bind the cytoplasmic domain of TLR4 and TLR9, but not TLR2, and to promote the ubiquitination and degradation of TLR4 and TLR9, but not TLR2.

Go back
583.25, 443.25
17.5, 17.5

p29

p29

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e39

e41 e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 TRIAD3A was a molecule found to bind the cytoplasmic domain of TLR4 and TLR9, but not TLR2, and to promote the ubiquitination and degradation of TLR4 and TLR9, but not TLR2.

Go back
1038.5, 78.5
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m15*m13*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR2, in combination with TLR1 or TLR6, recognizes triacyl lipopeptides and diacyl lipopeptides, respectively

Go back
582.5, 314.5
19.0, 19.0

p30

p30

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e41

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 TRIAD3A was a molecule found to bind the cytoplasmic domain of TLR4 and TLR9, but not TLR2, and to promote the ubiquitination and degradation of TLR4 and TLR9, but not TLR2.

Go back
736.5, 1480.5
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c78 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 16698941, 15004187 Transforming growth factor-? (TGF-?) suppresses the expression of TLR4

Go back
1096.5, 1560.5
23.0, 23.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e43 e42

MO000019394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 16698941, 15004187 Transforming growth factor-? (TGF-?) suppresses the expression of TLR4

Go back
974.5, 946.5
19.0, 19.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e5 e38

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c89 : 1
stoichiometry:c84 : 1

m44*m5*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 overexpression of TRIAD3A reduced TLR4- and TLR9-mediated nuclear factor (NF)-{kappa}B activation in response to L and CpG but not pI:C

Go back
1085.5, 1069.5
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e29 e38

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c87 : 1

m44*m29*0.1

nodelay

--

true

0

false

PMID: 16698941, 15107846 overexpression of TRIAD3A reduced TLR4- and TLR9-mediated nuclear factor (NF)-{kappa}B activation in response to L and CpG but not pI:C

Go back
1417.5, 317.5
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000022528

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m5*m6810*0.1

nodelay

--

true

0

false

PMID: 16698941, 16410796 Mal acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6, and MyD88.

Go back
1459.5, 407.5
17.0, 17.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45 MO000016573

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m46*m1572*0.1

nodelay

--

true

0

false

PMID: 16698941, 16410796 Mal acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6, and MyD88.

Go back
1077.5, 313.5
21.0, 21.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000022528

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m14*m6810*0.1

nodelay

--

true

0

false

PMID: 16698941, 16410796 Mal acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6, and MyD88.

Go back
1142.5, 302.5
19.0, 19.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 MO000016573

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m48*m1572*0.1

nodelay

--

true

0

false

PMID: 16698941, 16410796 Mal acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6, and MyD88.

Go back
1164.5, 132.5
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 MO000022528

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m11*m6810*0.1

nodelay

--

true

0

false

PMID: 16698941, 16410796 Mal acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6, and MyD88.

Go back
858.5, 570.5
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR3 recognizes double-stranded (ds)RNA, which is produced from many viruses during replication.

Go back
833.5, 133.5
21.0, 21.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000016573

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m63*m1572*0.1

nodelay

--

true

0

false

PMID: 16698941, 16410796 Mal acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6, and MyD88.

Go back
699.5, 635.5
17.0, 17.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000041446 MO000041125

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 16698941, 12471095 Trif interacts directly with TLR3.

Go back
1442.5, 482.5
19.0, 19.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000041132

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m5*m19005*0.1

nodelay

--

true

0

false

PMID: 16698941, 14556004 Tram is thought to act as a bridging adaptor between Trif and TLR4.

Go back
1447.5, 559.5
17.0, 17.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e65 MO000041125

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m66*m18998*0.1

nodelay

--

true

0

false

PMID: 16698941, 14556004 Tram is thought to act as a bridging adaptor between Trif and TLR4.

Go back
1425.5, 625.5
21.0, 21.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 MO000039077

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m47*m17258*0.1

nodelay

--

true

0

false

PMID: 16698941 MyD88 recruits IL-1R-associated kinase 4 (IRAK4) and TNF receptor-associated factor 6 (TRAF6) upon ligand stimulation.

Go back
1439.5, 715.5
17.0, 17.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e67 MO000000213

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m68*m184*0.1

nodelay

--

true

0

false

PMID: 16698941 Upon activation of TLR signaling, IRAK-1 and IRAK-4 are recruited to the receptor complex.

Go back
1444.5, 776.5
15.0, 15.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e68 MO000019406

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m69*m3973*0.1

nodelay

--

true

0

false

PMID: 16698941 At the receptor, IRAK-1 associates with Toll-interacting protein (Tollip), MyD88, and TRAF6, and phosphorylation by IRAK-4 triggers IRAK-1 hyperphosphorylation and dissociation of IRAK-1 from the complex while still maintaining its engagement with TRAF6.

Go back
1450.5, 922.5
19.0, 19.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e70 e124

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c292 : 1
stoichiometry:c131 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 16698941 At the receptor, IRAK-1 associates with Toll-interacting protein (Tollip), MyD88, and TRAF6, and phosphorylation by IRAK-4 triggers IRAK-1 hyperphosphorylation and dissociation of IRAK-1 from the complex while still maintaining its engagement with TRAF6. PMID: 16698941, 12885415 MyD88s inhibits the ability of IRAK4 to phosphorylate IRAK1, as unlike full-length MyD88, it is unable to interact with IRAK4.

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1418.5, 846.5
19.0, 19.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e69 MO000000212

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m70*m183*0.1

nodelay

--

true

0

false

PMID: 16698941 At the receptor, IRAK-1 associates with Toll-interacting protein (Tollip), MyD88, and TRAF6, and phosphorylation by IRAK-4 triggers IRAK-1 hyperphosphorylation and dissociation of IRAK-1 from the complex while still maintaining its engagement with TRAF6.

Go back
1448.5, 996.5
23.0, 23.0

p49

p49

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e71 MO000019406

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c134 : 1
stoichiometry:c133 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 16698941 Tollip interacts with IRAK-1, and IRAK-1 autophosphorylation is suppressed in the presence of Tollip.

Go back
894.5, 646.5
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m19940*m19*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, and single-stranded (ss)RNA derived from viruses such as human immunodeficiency virus.

Go back
1426.5, 1058.5
19.0, 19.0

p50

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 16698941, 11751856 Following TLR stimulation, IRAK-1 phosphorylates Tollip, and this may lead to the release of Tollip from the Tollip:IRAK-1 complex, thus overcoming negative regulation.

Go back
1409.5, 1121.5
21.0, 21.0

p51

p51

cso30:i:ME_Dissociation

cso30:i:CC_Extracellular

--

e73

MO000019406 e67 e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 16698941 At the receptor, IRAK-1 associates with Toll-interacting protein (Tollip), MyD88, and TRAF6, and phosphorylation by IRAK-4 triggers IRAK-1 hyperphosphorylation and dissociation of IRAK-1 from the complex while still maintaining its engagement with TRAF6. PMID: 16698941, 11751856 Following TLR stimulation, IRAK-1 phosphorylates Tollip, and this may lead to the release of Tollip from the Tollip:IRAK-1 complex, thus overcoming negative regulation

Go back
1279.5, 1203.5
17.0, 17.0

p52

p52

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e106 MO000017072

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c251 : 1
stoichiometry:c142 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 16698941 IRAK then becomes phosphorylated and dissociates from MyD88, which results in TRAF6 being activated, followed by TAK1/TAB1/TAB2/TAB3 complex formation and activation via K63-linked ubiquitination.

Go back
1181.5, 1341.5
21.0, 21.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016574 MO000016588 MO000022125 MO000041541

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c145 : 1

m1573*m1583*m6433*m19389*0.1

nodelay

--

true

0

false

PMID: 16698941 IRAK then becomes phosphorylated and dissociates from MyD88, which results in TRAF6 being activated, followed by TAK1/TAB1/TAB2/TAB3 complex formation and activation via K63-linked ubiquitination.

Go back
1126.5, 1134.5
19.0, 19.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76 e75

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m77*m76*0.1

nodelay

--

true

0

false

PMID: 16698941 IRAK then becomes phosphorylated and dissociates from MyD88, which results in TRAF6 being activated, followed by TAK1/TAB1/TAB2/TAB3 complex formation and activation via K63-linked ubiquitination.

Go back
941.5, 1049.5
21.0, 21.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m207*m78*0.1

nodelay

--

true

0

false

PMID: 16698941 Activated TAK1 complex then activates the inhibitor of {kappa}B (I{kappa}B) kinase (IKK) complex, which catalyzes I{kappa}B phosphorylation and degradation by the proteasome pathway, thus allowing NF-{kappa}B to translocate into nuclei.

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1017.5, 1073.5
21.0, 21.0

p56

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e80 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m81*m79*0.1

nodelay

--

true

0

false

PMID: 16698941 Activated TAK1 complex then activates the inhibitor of {kappa}B (I{kappa}B) kinase (IKK) complex, which catalyzes I{kappa}B phosphorylation and degradation by the proteasome pathway, thus allowing NF-{kappa}B to translocate into nuclei.

Go back
1035.5, 1211.5
25.0, 25.0

p57

p57

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e44

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 16698941 Activated TAK1 complex then activates the inhibitor of {kappa}B (I{kappa}B) kinase (IKK) complex, which catalyzes I{kappa}B phosphorylation and degradation by the proteasome pathway, thus allowing NF-{kappa}B to translocate into nuclei.

Go back
1009.25, 1165.25
21.5, 21.5

p58

p58

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e79

e44 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 16698941 Activated TAK1 complex then activates the inhibitor of {kappa}B (I{kappa}B) kinase (IKK) complex, which catalyzes I{kappa}B phosphorylation and degradation by the proteasome pathway, thus allowing NF-{kappa}B to translocate into nuclei.

Go back
1101.5, 529.5
21.0, 21.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 MO000019331 MO000016608

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m67*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR4 also recruits TRAM and Trif, which interacts with Traf family member-associated NF-{kappa}B activator-binding protein (TBK1), and TBK1, together with inducible IKK (IKKi), mediates phosphorylation of IFN regulatory factor 3 (IRF3).

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902.5, 718.5
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e22

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m19940*m22*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, and single-stranded (ss)RNA derived from viruses such as human immunodeficiency virus.

Go back
355.0, 483.0
26.0, 26.0

p60

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e82

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c168 : 1
stoichiometry:c167 : 1

m977*m83*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR4 also recruits TRAM and Trif, which interacts with Traf family member-associated NF-{kappa}B activator-binding protein (TBK1), and TBK1, together with inducible IKK (IKKi), mediates phosphorylation of IFN regulatory factor 3 (IRF3).

Go back
356.5, 644.5
23.0, 23.0

p61

p61

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 16698941 Phosphorylated IRF3 is dimerized and translocated into the nucleus to bind DNA.

Go back
384.5, 1020.5
23.0, 23.0

p62

p62

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 16698941 Phosphorylated IRF3 is dimerized and translocated into the nucleus to bind DNA.

Go back
666.5, 1398.5
19.0, 19.0

p63

p63

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e84 e86

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m85*m87*0.1

nodelay

--

true

0

false

PMID: 16698941 Phosphorylated IRF3 is dimerized and translocated into the nucleus to bind DNA.

Go back
1424.5, 1232.5
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000065 MO000000212 e66

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m88*m183*m67*0.1

nodelay

--

true

0

false

PMID: 16698941 Trif also interacts with TRAF6 and receptor-interacting protein kinase 1 (RIP1), which mediate NF-{kappa}B activation.

Go back
1159.5, 983.5
17.0, 17.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e87

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c182 : 1
stoichiometry:c181 : 1

m44*m89*0.1

nodelay

--

true

0

false

PMID: 16698941 Trif also interacts with TRAF6 and receptor-interacting protein kinase 1 (RIP1), which mediate NF-{kappa}B activation.

Go back
1071.5, 415.5
17.0, 17.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 MO000000212

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m6810*m183*0.1

nodelay

--

true

0

false

PMID: 16698941, 15247281 Mal interacts directly with TRAF6 to mediate NF-{kappa}B activation through TLR2 and TLR4.

Go back
778.75, 502.75
18.5, 18.5

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 MO000000212

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m65*m183*0.1

nodelay

--

true

0

false

PMID: 16698941, 14530355 Trif was found to mediate TLR3-induced activation of NF-{kappa}B via association with TRAF6.

Go back
1043.5, 999.5
17.0, 17.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e89 e108

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c191 : 1
stoichiometry:c259 : 1
stoichiometry:c190 : 1

m44*m91*0.1

nodelay

--

true

0

false

PMID: 16698941, 14530355 Trif was found to mediate TLR3-induced activation of NF-{kappa}B via association with TRAF6. PMID: 16698941 it was shown that TRAF1 is cleaved by caspase-8 generating two fragments, TRAF1(1?163) and TRAF1(164?416), and it is TRAF1(1?163) that is responsible for its inhibitory effects on Trif-mediated signaling. PMID: 16698941, 16323247 TRAF1 inhibited Trif and TLR3-mediated activation of NF-{kappa}B, IFN-stimulated response element, and IFN-? promoter activity

Go back
1223.75, 367.75
16.5, 16.5

p69

p69

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000022528 MO000001935 e5

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c194 : 1
stoichiometry:c201 : 1
stoichiometry:c193 : 1

m6810*m367*m5*0.1

nodelay

--

true

0

false

PMID: 16698941, 16415872, 16439361 We identified the Tec kinase, Bruton¡Çs tyrosine kinase (Btk), as the kinase responsible for phosphorylating Mal. PMID: 16698941 we have shown that after TLR2 and TLR4 stimulation, Mal becomes phosphorylated by Btk and then Mal interacts with SOCS-1, an E3 ligase, mediating Mal polyubiquitination and subsequent degradation via the 26S proteasome.

Go back
926.5, 782.5
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m19940*m24*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, and single-stranded (ss)RNA derived from viruses such as human immunodeficiency virus.

Go back
1153.5, 529.5
21.0, 21.0

p70

p70

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041132

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m19005*0.1

nodelay

--

true

0

false

PMID: 16698941, 12616480, 12721283, 14530355 It has also been reported that MyD88, Trif, and TRAM undergo phosphorylation.

Go back
1058.5, 554.5
19.0, 19.0

p71

p71

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016573

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m1572*0.1

nodelay

--

true

0

false

PMID: 16698941, 12616480, 12721283, 14530355 It has also been reported that MyD88, Trif, and TRAM undergo phosphorylation.

Go back
1153.5, 709.5
21.0, 21.0

p72

p72

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041125

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m18998*0.1

nodelay

--

true

0

false

PMID: 16698941, 12616480, 12721283, 14530355 It has also been reported that MyD88, Trif, and TRAM undergo phosphorylation.

Go back
1130.5, 342.5
19.0, 19.0

p73

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000022528 e14 MO000001935

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c203 : 1

m6810*m14*m367*0.1

nodelay

--

true

0

false

PMID: 16698941, 16415872, 16439361 We identified the Tec kinase, Bruton¡Çs tyrosine kinase (Btk), as the kinase responsible for phosphorylating Mal. PMID: 16698941 we have shown that after TLR2 and TLR4 stimulation, Mal becomes phosphorylated by Btk and then Mal interacts with SOCS-1, an E3 ligase, mediating Mal polyubiquitination and subsequent degradation via the 26S proteasome.

Go back
523.5, 427.5
17.0, 17.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e90 MO000017004

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c208 : 1
stoichiometry:c207 : 1

m92*m1906*0.1

nodelay

--

true

0

false

PMID: 16698941 we have shown that after TLR2 and TLR4 stimulation, Mal becomes phosphorylated by Btk and then Mal interacts with SOCS-1, an E3 ligase, mediating Mal polyubiquitination and subsequent degradation via the 26S proteasome.

Go back
417.5, 405.5
21.0, 21.0

p75

p75

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e94

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 16698941 we have shown that after TLR2 and TLR4 stimulation, Mal becomes phosphorylated by Btk and then Mal interacts with SOCS-1, an E3 ligase, mediating Mal polyubiquitination and subsequent degradation via the 26S proteasome.

Go back
418.5, 586.5
19.0, 19.0

p76

p76

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e95 MO000000218

MO000019479 MO000017004

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c214 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1

m97*m189*0.1

nodelay

--

true

0

false

PMID: 16698941 we have shown that after TLR2 and TLR4 stimulation, Mal becomes phosphorylated by Btk and then Mal interacts with SOCS-1, an E3 ligase, mediating Mal polyubiquitination and subsequent degradation via the 26S proteasome.

Go back
1045.5, 665.5
21.0, 21.0

p77

p77

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Extracellular

--

MO000016573 e42

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m1572*m42*0.1

nodelay

--

true

0

false

PMID: 16698941, 15623538 TGF-? induces MyD88 degradation by the proteasome and so down-regulates TLR signaling.

Go back
829.5, 1445.5
21.0, 21.0

p78

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c218 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 16698941, 15082713 treatment of the mouse macrophage cell line RAW264.7 with LPS for 1 and 3 h resulted in an increase in IRAK2c mRNA levels, indicating a possible negative-feedback loop.

Go back
1243.5, 1403.5
17.0, 17.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e97 MO000000212 MO000016573 MO000019406 e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m99*m183*m1572*m3973*m100*0.1

nodelay

--

true

0

false

PMID: 16698941 Unlike IRAK-1, the spliced variant IRAK-1c lacks kinase activity and cannot be phosphorylated by IRAK-4 but still retains its ability to interact with IRAK-2, MyD88, Tollip, and TRAF6.

Go back
890.5, 866.5
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19823*m25*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR8 mediates the recognition of imidazoquinolines and ssRNA.

Go back
1017.5, 1481.5
21.0, 21.0

p80

p80

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e100

G011134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c226 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 16698941, 12096038 A similar mechanism of decreased IRAK-1 protein was evident following exposure of peritoneal macrophages to the TLR7/8 ligand, R848.

Go back
1102.5, 1694.5
19.0, 19.0

p81

p81

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G011134 e100

MO000000213

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c229 : 1
stoichiometry:c228 : 1

m94019*0.1

nodelay

--

true

0

false

PMID: 16698941, 12096038 A similar mechanism of decreased IRAK-1 protein was evident following exposure of peritoneal macrophages to the TLR7/8 ligand, R848.

Go back
1269.5, 1349.5
21.0, 21.0

p82

p82

cso30:i:ME_Deubiquitination

cso30:i:CC_Extracellular

--

e75 MO000016591

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c233 : 1
stoichiometry:c232 : 1

m76*m1585*0.1

nodelay

--

true

0

false

PMID: 16698941, 15334086 It has been shown that the de-ubiquitination enzyme A20 terminates TLR signaling by removing ubiquitin moieties from TRAF6.

Go back
1241.5, 1669.5
21.0, 21.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017072 MO000000212 e5

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c237 : 1
stoichiometry:c236 : 1

m1964*m183*m5*0.1

nodelay

--

true

0

false

PMID: 16698941 it has been shown that ?-arrestins interact with TRAF6 in response to LPS and IL-1? stimulation

Go back
1163.5, 1703.5
25.0, 25.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017072 MO000000212 e102

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c239 : 1

m1964*m183*m104*0.1

nodelay

--

true

0

false

PMID: 16698941 it has been shown that ?-arrestins interact with TRAF6 in response to LPS and IL-1? stimulation

Go back
998.5, 1686.5
19.0, 19.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017072 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c243 : 1
stoichiometry:c244 : 1

m1964*m105*0.1

nodelay

--

true

0

false

PMID: 16698941, 10209148, 12488444, 11588219 ?-Arrestins, in addition to their established roles in receptor desensitization and endocytosis, bind to signaling molecules such as the Src family kinases and the E3 ligase Mdm2.

Go back
682.5, 1754.5
19.0, 19.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018839 MO000017072

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c247 : 1

m3461*m1964*0.1

nodelay

--

true

0

false

PMID: 16698941, 10209148, 12488444, 11588219 ?-Arrestins, in addition to their established roles in receptor desensitization and endocytosis, bind to signaling molecules such as the Src family kinases and the E3 ligase Mdm2.

Go back
1241.5, 1053.5
21.0, 21.0

p87

p87

cso30:i:ME_Oligomerization

cso30:i:CC_Extracellular

--

e74 MO000017072

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c250 : 1
stoichiometry:c248 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 16698941, 16378096 In terms of TLR signaling, it has been shown that ?-arrestins negatively regulate TLR signaling by preventing oligomerization of TRAF6, thereby inhibiting its autoubiquitination and subsequent signaling pathways such as NF-{kappa}B and AP-1 activation.

Go back
446.5, 954.5
19.0, 19.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016962 MO000041125

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c254 : 1

m1871*m18998*0.1

nodelay

--

true

0

false

PMID: 16698941 a recent study has shown that the C-domain of TRAF1 interacts with the TIR domain of Trif

Go back
504.5, 1128.5
23.0, 23.0

p89

p89

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000016962 MO000016900

e108 e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1
stoichiometry:c257 : 1
stoichiometry:c258 : 1

m1871*m1815*0.1

nodelay

--

true

0

false

PMID: 16698941 it was shown that TRAF1 is cleaved by caspase-8 generating two fragments, TRAF1(1?163) and TRAF1(164?416), and it is TRAF1(1?163) that is responsible for its inhibitory effects on Trif-mediated signaling.

Go back
887.5, 939.5
17.0, 17.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e22

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19823*m22*0.1

nodelay

--

true

0

false

PMID: 16698941 TLR8 mediates the recognition of imidazoquinolines and ssRNA.

Go back
531.5, 975.5
25.0, 25.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016962 MO000022528

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c262 : 1

m1871*m6810*0.1

nodelay

--

true

0

false

PMID: 16698941, 16323247 Mal and MyD88 interact with TRAF1, suggesting that TRAF1 may negatively regulate Mal and MyD88 signaling, although this remains to be fully explored.

Go back
367.5, 1147.5
17.0, 17.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016962 MO000016573

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m1871*m1572*0.1

nodelay

--

true

0

false

PMID: 16698941, 16323247 Mal and MyD88 interact with TRAF1, suggesting that TRAF1 may negatively regulate Mal and MyD88 signaling, although this remains to be fully explored.

Go back
423.5, 715.5
25.0, 25.0

p92

p92

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000000213

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1

m1872*m184*0.1

nodelay

--

true

0

false

PMID: 16698941, 16306937, 16306936 TRAF3 also interacts directly with Trif and IRAK-1, as well as the IRF3/7 kinases TBK1, IKKi, and putative intracellular viral receptor, protein kinase receptor.

Go back
485.0, 993.0
21.0, 21.0

p93

p93

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000016963

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c269 : 1
stoichiometry:c271 : 1

m18998*m1872*0.1

nodelay

--

true

0

false

PMID: 16698941, 16306937, 16306936 TRAF3 also interacts directly with Trif and IRAK-1, as well as the IRF3/7 kinases TBK1, IKKi, and putative intracellular viral receptor, protein kinase receptor.

Go back
325.0, 873.0
21.0, 21.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000019331

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c273 : 1
stoichiometry:c274 : 1

m1872*m3902*0.1

nodelay

--

true

0

false

PMID: 16698941, 16306937, 16306936 TRAF3 also interacts directly with Trif and IRAK-1, as well as the IRF3/7 kinases TBK1, IKKi, and putative intracellular viral receptor, protein kinase receptor.

Go back
476.0, 752.0
23.0, 23.0

p95

p95

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000016608

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c276 : 1
stoichiometry:c277 : 1

m1872*m1599*0.1

nodelay

--

true

0

false

PMID: 16698941, 16306937, 16306936 TRAF3 also interacts directly with Trif and IRAK-1, as well as the IRF3/7 kinases TBK1, IKKi, and putative intracellular viral receptor, protein kinase receptor.

Go back
415.0, 1159.0
17.0, 17.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e116 MO000016963

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c280 : 1

m118*m1872*0.1

nodelay

--

true

0

false

PMID: 16698941, 16306937, 16306936 TRAF3 also interacts directly with Trif and IRAK-1, as well as the IRF3/7 kinases TBK1, IKKi, and putative intracellular viral receptor, protein kinase receptor.

Go back
703.0, 1454.5
18.5, 18.5

p97

p97

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e85

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c282 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 16698941, 12692549, 14679297 Activated Trif recruits TBK1 and together with IKKi, mediate IRF3 phosphorylation, dimerization, and nuclear translocation mediating type 1 IFN induction.

Go back
511.0, 99.0
17.0, 17.0

p98

p98

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e119 MO000022528

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c284 : 1
stoichiometry:c285 : 1

m121*m6810*0.1

nodelay

--

true

0

false

PMID: 16698941 we have shown that ST2L, a type I transmembrane protein with three extracellular immunoglobulin-like domains and an intracellular TIR domain, interacts with and sequesters MyD88 and Mal, but not Trif or IRAK

Go back
655.0, 83.0
17.0, 17.0

p99

p99

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e119 MO000016573

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c286 : 1
stoichiometry:c287 : 1
stoichiometry:c288 : 1

m121*m1572*0.1

nodelay

--

true

0

false

PMID: 16698941 we have shown that ST2L, a type I transmembrane protein with three extracellular immunoglobulin-like domains and an intracellular TIR domain, interacts with and sequesters MyD88 and Mal, but not Trif or IRAK

Go back
1347.0, 255.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 501.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.0, 238.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1157.2331389036337, 329.68199782849996

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1155.0, 249.73823699513065

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1189.8, 162.4

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1181.2244646123283, 163.6845141153165

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.6864331224799, 147.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.6380401729833, 161.51832672959813

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.2143051726268, 158.03809599168804

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 155.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.5894663844041, 616.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 580.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.9291864478345, 570.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.0, 571.7611400011626

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1338.0, 311.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1222.0, 462.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1364.6819978285, 495.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1357.0, 529.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1290.0, 568.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1364.4390355750693, 571.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1351.0, 466.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1299.0, 636.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.1554175279994, 585.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1359.378701678827, 640.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1352.0, 681.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1299.0, 724.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1358.5009729298647, 727.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1351.0, 766.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1291.0, 784.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1358.444085216034, 787.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1351.0, 831.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1145.0, 856.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1359.1767122692816, 861.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 656.4437601569801

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1352.0, 903.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1354.8560515758452, 934.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1347.0, 961.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1361.0, 1008.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1288.0, 799.0

c134

c134

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1353.0, 1016.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1364.9346862024595, 1069.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1357.0, 1089.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1285.065548499491, 806.3893445174298

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1344.3871173249004, 703.8788264054339

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.3829385913779, 663.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1275.0, 1132.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1252.0, 1083.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1233.6307940059135, 1194.4022870018616

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1204.7771532427892, 1252.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.0, 1233.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.5575641729524, 1260.5748466757348

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1149.0, 1231.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1126.0, 1352.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1117.0, 1161.7462185896748

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.0, 1083.8125995884063

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
922.0, 656.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1152.9294846883888, 1153.9977796279165

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
952.0, 1012.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 1060.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.9980471729486, 1056.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1000.0, 1097.9115249081194

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.5942568689576, 1095.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.0, 1062.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
976.0, 1176.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1031.0, 1149.898929274113

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1020.0, 559.9972763131557

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 670.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.1367875253318, 1151.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.0337873398711, 1237.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1130.6358398242803, 545.3861999450876

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1114.0650607897096, 463.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.9380157342348, 247.360967183259

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.0, 559.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 439.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 509.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.6994814945797, 239.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 612.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.2725185831542, 733.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.3474977942105, 668.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
362.0, 834.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 1044.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.0, 1384.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
642.0, 1423.8623479330104

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 1388.4324545165464

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.0, 741.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.0, 869.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1347.0, 633.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1355.5183473879074, 1214.7339445046937

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.0, 728.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.0, 962.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.9400144867332, 1001.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.9206650306735, 1007.3076981265679

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1095.6314143499878, 335.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.9493417962155, 440.94347217241665

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 424.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.0, 522.2573723617468

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.6568542494924, 526.6568542494924

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.8010628463317, 514.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1065.3813823519704, 967.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.0, 673.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 1017.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.0, 550.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1229.0, 340.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.9853479730496, 377.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.0, 290.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1173.7777713001233, 474.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.0, 507.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.9851434967002, 432.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.9732787458232, 316.32164833718804

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.7352760232802, 582.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1458.0, 296.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.8094964814716, 794.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.0829894255471, 593.1958868009881

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1246.145770236779, 304.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1157.6136689420844, 329.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.5244311975337, 355.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1063.0, 237.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
551.0, 290.0

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
548.9650738084744, 390.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.4198060380143, 357.88436084127267

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 453.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.1723892887157, 352.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0, 792.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 427.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 521.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.0, 541.7340911300676

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.0, 527.1675379317294

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.0, 375.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1064.5777087639997, 432.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.1119090269774, 559.9223518172148

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
907.0, 694.9437988874674

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 1467.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.1032901186056, 315.0

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
844.0, 869.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1198.0, 1422.7551284886704

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1135.0, 869.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1185.0, 432.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1252.3039126948036, 799.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1252.0, 1429.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.6527867957748, 1421.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
989.9301186488644, 1503.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.0, 1629.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1114.0, 746.8806632889705

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.4318989519804, 1510.0

c229

c229

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
918.0, 876.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.9997959548039, 1492.0404019793414

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1218.0, 1203.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1188.1730332109582, 812.0885814306548

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1280.2104534567059, 1378.9972313548228

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1217.0, 1698.2012740113241

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.0, 869.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.0, 1691.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1259.0785070076854, 315.0

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1187.0309682041927, 1735.9102312071875

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1189.0, 1717.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.5476811172091, 879.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.0, 869.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 1736.9984922728852

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1025.477978187456, 1702.8425063285652

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.0, 1707.8350918509939

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1010.0, 1706.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 1764.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.9989208193293, 1764.1313991099685

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.5088217228453, 1695.7599993359647

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1175.3879889704083, 818.6352805238058

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1172.0, 811.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.0, 880.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1209.0, 1078.992347180777

c250

c250

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1211.0, 1224.9597979746447

c251

c251

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
464.5777087639997, 981.1554175279994

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.2053904569946, 575.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 890.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.0, 1094.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.1422644518435, 1079.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
478.42469075791234, 1152.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 1140.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.0, 1012.5002349173293

c259

c259

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
901.3473652535891, 738.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 1008.5067449345369

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.7394861728918, 340.0

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 1001.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.89872554137804, 1087.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.91373695841946, 431.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
377.0, 1165.0

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 673.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.999904820259, 724.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.1377589008833, 741.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 673.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.0, 948.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.9853987146693, 576.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.71941893171646, 966.1001360328935

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.77607105433646, 673.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.9880404621422, 455.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 889.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 673.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.80389206789573, 628.0

c276

c276

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.4, 773.0

c277

c277

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 1089.0

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 673.0

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 608.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.0, 1176.0

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.785492236829, 1385.0

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
656.4960910592349, 1473.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 122.67750815368576

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.6508125684107, 112.33774828479216

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 116.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 102.25192856851149

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.7687321443115, 101.26430125091619

c287

c287

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.2613347817921, 100.0

c288

c288

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.35990680476334, 157.7075489304051

c289

c289

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 561.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
405.5505626283451, 147.64367244480817

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.0, 151.0

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 938.7930392413537

c292

c292

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
414.0, 1474.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.26490581247606, 432.0

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.52586312860234, 1578.0

c295

c295

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.41972422188803, 1557.8730161395608

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.99617177673224, 737.0

c297

c297

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.379042654018, 1496.8802437372456

c298

c298

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1346.0, 296.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 617.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.0, 681.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0231645833151, 727.8308170454446

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.0, 729.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.6115561484353, 880.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 907.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 839.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 1232.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
846.9057664270523, 1234.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.0, 1225.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.0, 34.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 1244.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.2963824580329, 315.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.0, 625.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
738.0809056378665, 966.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
677.6843529752741, 781.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
634.0, 1301.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 695.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.0, 1417.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0, 1354.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
961.7794900556852, 1327.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1228.5777087639997, 114.15541752799933

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.5039049293385, 1382.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.1709862283207, 1437.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1029.0752616968539, 315.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.0, 625.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.0, 695.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
849.0, 781.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.0, 965.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.1972533026425, 452.4927846909883

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.9102312071875, 403.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.0784191224138, 386.8823322690734

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1221.0, 107.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0809056378665, 1365.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.3403667795809, 383.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
955.0, 296.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 242.29269405511226

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.0, 296.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.0, 465.37029138533205

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.5412876511472, 303.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.670591992256, 458.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.0, 235.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 403.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.0, 64.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.2394443073428, 313.0455126623185

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.0, 485.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.0, 496.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 469.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 415.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 304.7301828183659

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 342.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.0, 329.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 1504.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.2836150598343, 1507.7884472252053

c79

c79

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1053.7623602519652, 105.50795350534106

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.0, 1572.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1110.0, 270.88850755700815

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.0, 1587.5238222760609

c82

c82

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1002.0, 956.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 966.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.6940032528023, 315.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1096.3104456000465, 967.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.6075531497706, 1091.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.0, 684.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.0, 311.0

c89

c89

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1048.0, 98.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 311.0

c90

c90

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1338.0, 299.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1244.0, 324.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1362.9665944727706, 334.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1356.0, 380.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1196.0, 416.12119821037015

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1360.8213480118193, 418.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1058.0, 237.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.0, 324.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 245.4743427946259

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back