1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16723122.csml convertedTime:2009.07.01.10:55

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title NF-kappaB activation by reactive oxygen species: fifteen years later.
Authors Gloire G, Legrand-Poels S, Piette J.
Affiliation Center for Biomedical Integrated Genoproteomics (CBIG), Virology and ImmunologyUnit, University of Liege, 4000 Liege, Belgium.
Abstract The transcription factor NF-kappaB plays a major role in coordinating innate andadaptative immunity, cellular proliferation, apoptosis and development. Sincethe discovery in 1991 that NF-kappaB may be activated by H(2)O(2), severallaboratories have put a considerable effort into dissecting the molecularmechanisms underlying this activation. Whereas early studies revealed anatypical mechanism of activation, leading to IkappaBalpha Y42 phosphorylationindependently of IkappaB kinase (IKK), recent findings suggest that H(2)O(2)activates NF-kappaB mainly through the classical IKK-dependent pathway. Themolecular mechanisms leading to IKK activation are, however, cell-type specificand will be presented here. In this review, we also describe the effect of otherROS (HOCl and (1)O(2)) and reactive nitrogen species on NF-kappaB activation.Finally, we critically review the recent data highlighting the role of ROS inNF-kappaB activation by proinflammatory cytokines (TNF-alpha and IL-1beta) andlipopolysaccharide (LPS), two major components of innate immunity.
PMID 16723122
Model Abstract

Entity

G010329:TNF-alpha G010514:iNOS G011488:HDAC2 MO000000022:p38{active} MO000000023:JNK MO000000030:PI3K MO000000079:ASK1 MO000000166:Rac1 MO000000194:RelB MO000000196:p52 MO000000202:p100 MO000000203:NIK MO000000207:TRADD MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK MO000000214:IL-1 MO000000248:IKK MO000000276:AP-1 MO000000289:TNF-alpha MO000008301:Syk MO000016573:MyD88 MO000016574:TAK1 MO000016597:IL-1beta MO000016599:IKK-gamma MO000016882:LPS MO000017065:PKCdelta MO000017583:PtdIns{p} MO000017690:BCR MO000017772:ZAP-70 MO000017777:TCR MO000017876:XIAP MO000018132:CD14 MO000018873:SODD MO000019394:TLR4 MO000019406:Tollip MO000019420:LBP MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000062257:tPA MO000068593:NOX4 MO000078383:PKD e1: e10:RelA-p65 e100:TNFR:TNF-alpha:TRADD:TRAF:RIP1 e101:TNFR:TNF-alpha:TRADD:TRAF:RIP1:nemo e102:NAC e103:PTDC e104:IL-1R e105:Il-1:Il-1R e106:RelA-p65{p} e107:MEKK7 e108:MEKK7{inactive} e109:GADD45beta e11:phagocytic NADPH oxidases e110:JNK{active} e111:ROS e112:LPS:TLR4:MyD88 e113:LPS:TLR4:MyD88:IRAK e114:LPS:TLR4:MyD88:IRAK:TRAF6 e115:LPS:TLR4:MyD88:IRAK:TRAF6:Nox4 e116:alpha-octopherol e117:DMSO e118:MAPK phosphatases e119:MAPK phosphatases{oxidized} e12:Non-phagocytic oxidases e120:MAPK phosphatases{oxidized}{ub} e126:ASK1:TRAF6 e127:p38 e13:Myeloperoxidase e14:BHA e15:NF-KappaB e16:NF-KappaB:IKappaB e17:IKappaB e18:TNF-alphaR e19:TNF-alpha:TNF-alphaR e2: e20:IL-1betaR e21:IL-1beta:IL-1betaR e22:TLRs e23:PAMPs e24:TLRs:PAMPs e25:T-cell antigen e26:B-cell antigen e27:T-cell antigen:TCR e28:B-cell antigen:BCR e29:IKK{p} e3: e30:NF-KappaB:IKappaB{p} e31:NF-KappaB:IKappaB{p}{ub} e32: degradants e33:NF-KappaB e34:cytokines e35:chemokines e36:adhesion molecules e37:inhibitors of apoptosis e38:BAFF e39:Lymphotoxin beta e4: e40:CD40 e41:RelB:p52 e42:RelB:p52 e43:DNA e44:RelB:p52:DNA e45:H2O2 e46:Bfl-1 e47:calpain e48:pervanadate e49:IKK{active} e5:lipoxygenases e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:superoxide anion e60: e61: e62: e63:SHIP-1 e64:PtdIns e65:Inorganic phosphate e66:Src e67:Src{active} e68:Ab1 e69:PKD{pY463} e7:p56Lck e70:PKD{pS738/S742} e71:IKK{oxidized} e72:Chloride ion e73:NH2Cl e74:HOCl e75:amines e76:chloramines e77:N-chlorinated derivatives e78:LPS:TLR4 e79:Taurine chloramine e8: e80:IKappaB{oxidized} e81:degradants e82:GlyCl e83:peroxinitrite e84:NO e85:superoxide e86:Rac1{active} e87:IL-1RacP e88:Il-1beta:IL-1R1:IL-1RacP e89:IL-1beta:IL-1R1:IL-1RcaP:MyD88 e9:cycloxygenases e90:IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip e91:IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip:IRAK e92:IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip:IRAK:TRAF6 e93:IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip:IRAK:TRAF6:TAK1 e94:AP-1{active} e95:TNFR:SODD e96:TNFR:TNF:alpha:TRADD e97:TRAF e98:TNFR:TNF-alpha:TRADD:TRAF e99:RIP1

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p88 p89 p9 p90 p93 p94 p95
Model Detail
444.0, 1156.0
32.0, 32.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p54

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
353.0, 1141.0
30.0, 30.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p53

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
564.0, 1172.0
24.0, 24.0

HDAC2

--

G011488

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p75

--

true true true true

csml-variable:Double

m94365

10

false

infinite

0

unit false false false
TRANSFACG011488

--

Go back
275.0, 1283.0
24.5, 24.5

p38{active}

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

p94

--

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
823.0, 1199.0
26.0, 26.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p79 p5

true true true true

csml-variable:Double

m111

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
779.0, 831.0
34.0, 34.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
776.0, 1204.0
24.0, 24.0

ASK1

--

MO000000079

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93

true true true true

csml-variable:Double

m128

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000079

--

Go back
640.0, 1252.0
24.0, 24.0

Rac1

--

MO000000166

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m146

10

false

infinite

0

unit false false false
TRANSPATHMO000000166

--

Go back
606.0, 702.0
28.0, 28.0

RelB

--

MO000000194

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m167

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
755.0, 767.0
26.0, 26.0

p52

--

MO000000196

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25 p27 p28

p29

true true true true

csml-variable:Double

m168

10

false

infinite

0

unit false false false
TRANSPATHMO000000196

--

Go back
660.0, 636.0
23.0, 23.0

p100

--

MO000000202

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p27 p28

true true true true

csml-variable:Double

m173

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
843.0, 663.0
26.0, 26.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p27 p28

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
900.0, 340.0
24.0, 24.0

TRADD

--

MO000000207

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p68

true true true true

csml-variable:Double

m178

10

false

infinite

0

unit false false false
InterProIPR000488
TRANSPATHMO000000207

--

Go back
618.0, 258.0
27.0, 27.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26 p27 p28

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
521.0, 249.0
29.0, 29.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
247.0, 283.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63 p82 p93

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
301.0, 249.0
21.0, 21.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62 p81

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
27.0, 903.0
26.0, 26.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
678.0, 250.0
28.0, 28.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p8 p13 p14 p15 p16 p37 p45 p47 p52 p65

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
673.0, 797.0
30.5, 30.5

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1078.0, 126.0
28.0, 28.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
295.0, 667.0
25.0, 25.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
375.0, 207.0
26.0, 26.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60 p80

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
257.0, 329.0
30.0, 30.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
684.0, 52.0
32.0, 32.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
518.0, 202.0
27.0, 27.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p71

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
421.0, 73.0
22.0, 22.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
162.0, 738.0
28.0, 28.0

PKCdelta

--

MO000017065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m1957

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017065

--

Go back
958.0, 930.0
28.0, 28.0

PtdIns{p}

--

MO000017583

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p39

true true true true

csml-variable:Double

m347277

10

false

infinite

0

unit false false false
TRANSPATHMO000017583

--

Go back
1007.0, 587.0
34.0, 34.0

BCR

--

MO000017690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m2450

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
167.0, 519.0
26.0, 26.0

ZAP-70

--

MO000017772

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m2529

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017772

--

Go back
1006.0, 478.0
35.0, 35.0

TCR

--

MO000017777

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m2534

10

false

infinite

0

unit false false false
TRANSPATHMO000017777

--

Go back
946.0, 1122.0
28.0, 28.0

XIAP

--

MO000017876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m2619

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000017876

--

Go back
155.0, 135.0
26.0, 26.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p85

p50

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
924.0, 212.0
24.0, 24.0

SODD

--

MO000018873

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p67

true true true true

csml-variable:Double

m3491

10

false

infinite

0

unit false false false
InterProIPR003103
TRANSPATHMO000018873

--

Go back
407.0, 139.0
26.0, 26.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
260.0, 216.0
24.0, 24.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
293.0, 1.0
22.0, 22.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

p85

p84

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
264.0, 60.0
23.0, 23.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p84

p50

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
249.0, 133.0
30.0, 30.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p85

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
33.0, 713.0
30.0, 30.0

tPA

--

MO000062257

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p72

true true true true

csml-variable:Double

m37148

10

false

infinite

0

unit false false false
TRANSPATHMO000062257

--

Go back
190.0, 654.0
27.0, 27.0

NOX4

--

MO000068593

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m43439

10

false

infinite

0

unit false false false
TRANSPATHMO000068593

--

Go back
297.0, 733.0
30.0, 30.0

PKD

--

MO000078383

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m53120

10

false

infinite

0

unit false false false
TRANSPATHMO000078383

--

Go back
99.75, 117.99690800911759
961.2440144089819, 1395.7263089218397

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
747.0, 1379.0
26.0, 26.0

RelA-p65

--

e10

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m10

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000080947

--

Go back
1013.0, 417.0
22.764705882352946, 37.941176470588246

TNFR:TNF-alpha:TRADD:TRAF:RIP1

--

e100

cso30:c:Complex

cso30:i:CC_Extracellular

--

p70

p71

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1009.0, 709.0
22.764705882352946, 37.941176470588246

TNFR:TNF-alpha:TRADD:TRAF:RIP1:nemo

--

e101

cso30:c:Complex

cso30:i:CC_Extracellular

--

p71

p78

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
31.0, 500.0
41.73254835996636, 23.648444070647603

NAC

--

e102

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p19 p35 p76 p79 p5 p83

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
22.0, 803.0
44.331370899915896, 25.121110176619005

PTDC

--

e103

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p18 p72 p74

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
123.5, 897.0
25.01757469244288, 38.48857644991213

IL-1R

--

e104

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p73

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
124.5, 978.0
23.013812760359567, 44.54286340714756

Il-1:Il-1R

--

e105

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p73

p74

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
523.0, 1395.0
26.0, 26.0

RelA-p65{p}

--

e106

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

--

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000080947

--

Go back
806.0, 1288.5
36.74381163211914, 22.658683839806802

MEKK7

--

e107

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p79 p77

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
938.0, 1304.5
36.74381163211914, 22.658683839806802

MEKK7{inactive}

--

e108

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

p77

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
937.5, 1351.0
21.348158583215938, 34.61863554035017

GADD45beta

--

e109

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p77

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
257.5, 623.0
21.385389414369094, 34.67900986113907

phagocytic NADPH oxidases

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
879.0, 1235.0
26.0, 26.0

JNK{active}

--

e110

cso30:c:Protein

cso30:i:CC_CellComponent

--

p79 p5

--

true true true true

csml-variable:Double

m112

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
752.0, 1015.0
47.157275021026074, 26.722455845248103

ROS

--

e111

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

p78 p95

p5 p89 p93 p58

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
563.5, 135.0
24.660488162965684, 34.40998348320794

LPS:TLR4:MyD88

--

e112

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p80

p81

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
636.0, 124.0
23.647058823529413, 39.411764705882355

LPS:TLR4:MyD88:IRAK

--

e113

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p81

p82

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
124.0, 468.0
23.647058823529413, 39.411764705882355

LPS:TLR4:MyD88:IRAK:TRAF6

--

e114

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p82

p86

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
112.0, 676.0
23.647058823529413, 39.411764705882355

LPS:TLR4:MyD88:IRAK:TRAF6:Nox4

--

e115

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p86

p83 p95

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
22.0, 1063.0
45.03784693019344, 25.52144659377628

alpha-octopherol

--

e116

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p35 p83

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
28.0, 847.0
47.48528174936922, 26.90832632464255

DMSO

--

e117

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p35 p83

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
380.0, 1412.0
24.0, 24.0

MAPK phosphatases

--

e118

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p89

true true true true

csml-variable:Double

m120

10

false

infinite

0

unit false false false
TRANSPATHMO000017179

--

Go back
332.0, 1380.0
24.0, 24.0

MAPK phosphatases{oxidized}

--

e119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p89

p88

true true true true

csml-variable:Double

m121

10

false

infinite

0

unit false false false
TRANSPATHMO000017179

--

Go back
456.5, 470.0
22.182129201046482, 35.971020326021325

Non-phagocytic oxidases

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
192.0, 1332.0
24.0, 24.0

MAPK phosphatases{oxidized}{ub}

--

e120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88

p90

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
TRANSPATHMO000017179

--

Go back
553.5, 1351.0
28.031494750874863, 34.32427928678555

ASK1:TRAF6

--

e126

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p93

p94

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
384.0, 1364.0
24.5, 24.5

p38

--

e127

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p94

true true true true

csml-variable:Double

m131

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
872.0, 1085.0
16.137511693171188, 37.2404115996258

Myeloperoxidase

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p48

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
674.0, 1543.0
45.13877207737594, 25.578637510513033

BHA

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p79 p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
510.0, 709.5
35.01710605755686, 21.593882068826726

NF-KappaB

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

p19 p32 p34 p35 p36 p38 p46 p51 p83

p6 p20 p79 p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
545.5, 454.0
29.66455590734877, 36.323946008998504

NF-KappaB:IKappaB

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p17 p32 p35 p38 p46 p51 p83

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
567.0, 330.5
25.759999999999994, 19.32

IKappaB

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6 p55

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1018.5, 191.0
27.53075571177504, 42.355008787346215

TNF-alphaR

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p67

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1012.5, 247.0
22.06906380179785, 42.71431703573778

TNF-alpha:TNF-alphaR

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p14 p46 p56 p66 p68

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
99.75, 117.99690800911759
961.2440144089819, 1395.7263089218397

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
706.5, 127.0
27.325131810193323, 42.038664323374334

IL-1betaR

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
800.5, 125.0
23.67309800482351, 45.818899364174534

IL-1beta:IL-1betaR

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p8 p59

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
858.5, 131.0
27.18804920913884, 41.82776801405976

TLRs

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
870.0, 60.5
35.36028119507909, 22.984182776801408

PAMPs

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
932.5, 130.0
22.266169699627273, 43.09581232185924

TLRs:PAMPs

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p13

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1075.0, 484.5
34.44639718804921, 22.39015817223199

T-cell antigen

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1071.0, 585.5
33.81370826010546, 21.978910369068544

B-cell antigen

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1012.5, 529.0
23.448805086603812, 45.38478403858802

T-cell antigen:TCR

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p15

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1008.5, 641.0
23.84301688226266, 46.147774610830965

B-cell antigen:BCR

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p16

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
690.0, 378.0
28.0, 28.0

IKK{p}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p13 p14 p15 p16 p65

p17

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
118.9748802881796, 137.22178829729728
922.7942538326226, 1357.2765483454818

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
534.5, 519.0
27.353774370938176, 33.494417597067155

NF-KappaB:IKappaB{p}

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18 p34 p36

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
479.5, 581.0
24.19380103316114, 29.62506248958507

NF-KappaB:IKappaB{p}{ub}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19 p72 p74

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
354.0, 646.0
27.966685812751287, 27.034462952326248

degradants

--

e32

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p19 p34 p51 p72 p74 p83 p90

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
466.0, 885.5
35.01710605755686, 21.593882068826726

NF-KappaB

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20

p21 p22 p23 p24 p33 p53 p54

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
258.0, 940.0
44.74048442906575, 23.86159169550173

cytokines

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
304.0, 991.0
48.68512110726643, 25.965397923875436

chemokines

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p22

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
335.0, 1047.0
50.19031141868512, 26.768166089965398

adhesion molecules

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p23

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
482.0, 1046.0
51.64359861591696, 27.543252595155714

inhibitors of apoptosis

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1081.5, 707.0
21.1620044274502, 34.31676393640572

BAFF

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1081.5, 759.0
20.908834775608778, 33.90621855504126

Lymphotoxin beta

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
154.54090882131217, 170.86532880161138
851.6621967663583, 1289.9894673368515

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1073.0, 823.5
37.71528998242531, 24.514938488576448

CD40

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
633.5, 851.0
28.162139643392766, 34.48425262456257

RelB:p52

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p30

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
557.5, 915.0
28.162139643392766, 34.48425262456257

RelB:p52

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
610.0, 1001.5
60.0, 13.0

DNA

--

e43

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p31

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
626.0, 1087.5
60.0, 17.0

RelB:p52:DNA

--

e44

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p31

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1065.0, 879.0
45.769554247266605, 25.936080740117745

H2O2

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p32 p35 p37 p42 p47 p48 p75

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
539.0, 1099.0
50.19031141868512, 26.768166089965398

Bfl-1

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p33

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
797.0, 567.0
45.21446593776283, 25.6215306980656

calpain

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
28.0, 618.0
48.59545836837679, 27.537426408746846

pervanadate

--

e48

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
682.0, 322.0
28.0, 28.0

IKK{active}

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37 p45 p52

p38

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
293.0, 404.5
37.57697725900584, 23.172469309720267

lipoxygenases

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
198.5015526945721, 851.0
503.6900148038766, 456.79150318340464

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
252.9038261743205, 861.8252945550544
294.5226529765685, 442.72194969726263

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
205.06734432143836, 857.0968065106615
490.55843155014475, 444.59789016208146

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
206.00531455384763, 858.0347767430709
488.6824910853254, 442.72194969726263

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
198.5015526945721, 851.0
503.6900148038766, 456.79150318340464

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
198.5015526945721, 851.0
503.6900148038766, 456.79150318340464

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
206.00531455384763, 858.0347767430709
488.6824910853254, 442.72194969726263

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
566.1858837990778, 1038.5940464818914
31.467784598107915, 28.486626057234577

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
483.6445033470468, 1169.9098790192143
89.10717207889809, 80.66543998721313

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
198.5015526945721, 851.0
503.6900148038766, 456.79150318340464

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
229.94280908326323, 469.1009251471825
52.58200168208578, 29.79646761984861

superoxide anion

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p1 p2 p3 p4

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
317.2184551152057, 1053.9943695154416
15.951122674104438, 7.680170176420663

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
316.6858019781632, 1031.0902846226154
54.5969465468522, 98.27450378433399

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
339.58988687098963, 1095.0086610677108
8.522450192679345, 8.522450192679356

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
778.0, 901.5
28.32, 21.239999999999995

SHIP-1

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
950.0, 998.0
28.0, 28.0

PtdIns

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000017583

--

Go back
911.5, 1059.0
25.304759214800168, 25.733653438779836

Inorganic phosphate

--

e65

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
560.0, 745.0
16.45369504209542, 37.97006548175865

Src

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
452.0, 798.0
15.66323666978485, 36.14593077642657

Src{active}

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p42

p43 p83

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
353.0, 718.5
30.10263634534111, 18.563292412960354

Ab1

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
241.0, 789.0
30.0, 30.0

PKD{pY463}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

p44

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSPATHMO000078383

--

Go back
180.0, 563.5
32.31999999999999, 24.240000000000002

p56Lck

--

e7

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p35

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
225.0, 717.0
30.0, 30.0

PKD{pS738/S742}

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

p45

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000078383

--

Go back
658.0, 494.0
28.0, 28.0

IKK{oxidized}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

p46

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1121.0, 915.0
45.441547518923464, 25.750210260723293

Chloride ion

--

e72

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p48

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
545.0, 67.0
45.69386038687974, 25.89318755256518

NH2Cl

--

e73

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p46

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1062.0, 1046.0
51.143818334735066, 28.98149705634987

HOCl

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p48

p49

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1156.0, 1025.0
44.7098402018503, 25.335576114381826

amines

--

e75

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p49

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1170.0, 1179.0
44.58368376787216, 25.26408746846089

chloramines

--

e76

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p49

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1188.0, 1118.0
48.16652649285113, 27.29436501261565

N-chlorinated derivatives

--

e77

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p49

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
480.5, 133.0
23.6730980048235, 45.81889936417452

LPS:TLR4

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p85

p51 p52 p80

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1063.0, 1218.0
50.386879730866276, 28.55256518082422

Taurine chloramine

--

e79

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p49

p51 p52 p56

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
138.89745661942976, 146.1625838399333
890.1304376920662, 1292.4693955288797

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
651.0, 666.5
25.759999999999994, 19.32

IKappaB{oxidized}

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p55

p56

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1070.0, 1278.0
28.621481906950034, 27.667432510051693

degradants

--

e81

cso30:c:EntityBiological

cso30:i:CC_Extracellular

--

p56

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
627.0, 66.0
49.02439024390244, 27.78048780487805

GlyCl

--

e82

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p46

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1065.0, 1519.0
45.946173254836, 26.036164844407057

peroxinitrite

--

e83

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

p57

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1082.0, 1332.0
43.6753574432296, 24.749369217830107

NO

--

e84

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

--

p57

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1112.0, 1383.0
47.333894028595466, 26.822539949537425

superoxide

--

e85

cso30:c:SmallMolecule

cso30:i:CC_Cell_WithoutCellWall_

--

--

p57

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
764.0, 1328.0
24.0, 24.0

Rac1{active}

--

e86

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58

--

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000000166

--

Go back
350.5, 115.0
27.142355008787348, 41.75746924428822

IL-1RacP

--

e87

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p59

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
293.5, 116.0
29.198017984951374, 40.7414204441182

Il-1beta:IL-1R1:IL-1RacP

--

e88

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p59

p60

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
116.0, 140.0
24.35294117647059, 40.58823529411765

IL-1beta:IL-1R1:IL-1RcaP:MyD88

--

e89

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p60

p61

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
369.0, 280.5
29.440000000000012, 22.080000000000013

cycloxygenases

--

e9

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
128.0, 192.0
24.35294117647059, 40.58823529411765

IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip

--

e90

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p61

p62

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
120.0, 264.0
24.35294117647059, 40.58823529411765

IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip:IRAK

--

e91

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p62

p63

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
124.0, 332.0
24.35294117647059, 40.58823529411765

IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip:IRAK:TRAF6

--

e92

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p63

p64

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
116.0, 396.0
24.35294117647059, 40.58823529411765

IL-1beta:IL-1R1:IL-1RcaP:MyD88:Tollip:IRAK:TRAF6:TAK1

--

e93

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p64

p65

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
721.0, 905.0
30.5, 30.5

AP-1{active}

--

e94

cso30:c:Protein

cso30:i:CC_CellComponent

--

p66

--

true true true true

csml-variable:Double

m95

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1003.7481911861432, 136.73843455382593
24.162464371848284, 46.76606007454507

TNFR:SODD

--

e95

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p67

p7

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1011.5, 314.0
25.24444852266471, 35.2248118920903

TNFR:TNF:alpha:TRADD

--

e96

cso30:c:Complex

cso30:i:CC_Extracellular

--

p68

p69

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
836.0, 363.0
15.043030869971933, 34.714686623012156

TRAF

--

e97

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p69

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1009.0, 369.0
22.764705882352946, 37.941176470588246

TNFR:TNF-alpha:TRADD:TRAF

--

e98

cso30:c:Complex

cso30:i:CC_Extracellular

--

p69

p70

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
867.0, 478.5
26.4, 19.8

RIP1

--

e99

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p70

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
186.0, 414.0
19.0, 19.0

p1

p1

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 16723122,10225417 ROS are generated through multiple sources in the cell, such as the electron transport chain in mitochondria, ionizing radiations and through enzymes producing superoxide anion such as phagocytic and non-phagocytic NADPH oxidases , lipoxygenases and cycloxygenases.

Go back
961.0, 61.0
21.0, 21.0

p7

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m23*m22*0.1

nodelay

--

true

0

false

PMID; 16723122,16343886 The classical NF-kB-activating pathway is induced by a variety of innate and adaptative immunity mediators, such as proinflammatory cytokines (TNFa, IL-1b, Toll-like receptors (TLRs) and antigen receptors (TCR, BCR) ligation

Go back
1081.0, 545.0
21.0, 21.0

p7

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000017777

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m25*m2534*0.1

nodelay

--

true

0

false

PMID; 16723122,15134788,15145317,16439988 The classical NF-kB-activating pathway is induced by a variety of innate and adaptative immunity mediators, such as proinflammatory cytokines (TNFa, IL-1b, Toll-like receptors (TLRs) and antigen receptors (TCR, BCR) ligation

Go back
1077.0, 657.0
21.0, 21.0

p7

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000017690

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m26*m2450*0.1

nodelay

--

true

0

false

PMID; 16723122,12421671,10795740 The classical NF-kB-activating pathway is induced by a variety of innate and adaptative immunity mediators, such as proinflammatory cytokines (TNFa, IL-1b, Toll-like receptors (TLRs) and antigen receptors (TCR, BCR) ligation

Go back
825.0, 217.0
21.0, 21.0

p8

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e24 MO000000248

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m24*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,9657155,9346241 Whereas all these NF-kB inducers signal through different receptors and adaptor proteins, they all converge to the activation of the so called IkB-kinase (IKK) complex, which includes the scaffold protein NF-kB essential modulator (NEMO, also called IKKg, IKKa and IKKb kinases.

Go back
845.0, 265.0
21.0, 21.0

p8

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000248 e19

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c36 : 1

m207*m19*0.1

nodelay

--

true

0

false

PMID: 16723122,9657155,9346241 Whereas all these NF-kB inducers signal through different receptors and adaptor proteins, they all converge to the activation of the so called IkB-kinase (IKK) complex, which includes the scaffold protein NF-kB essential modulator (NEMO, also called IKKg, IKKa and IKKb kinases.

Go back
853.0, 421.0
21.0, 21.0

p8

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e27 MO000000248

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m27*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,9657155,9346241 Whereas all these NF-kB inducers signal through different receptors and adaptor proteins, they all converge to the activation of the so called IkB-kinase (IKK) complex, which includes the scaffold protein NF-kB essential modulator (NEMO, also called IKKg, IKKa and IKKb kinases.

Go back
781.0, 489.0
21.0, 21.0

p8

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e28 MO000000248

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m28*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,9657155,9346241 Whereas all these NF-kB inducers signal through different receptors and adaptor proteins, they all converge to the activation of the so called IkB-kinase (IKK) complex, which includes the scaffold protein NF-kB essential modulator (NEMO, also called IKKg, IKKa and IKKb kinases.

Go back
681.0, 541.0
21.0, 21.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e29 e16

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m29*m16*0.1

nodelay

--

true

0

false

PMID: 16723122 Once activated by phosphorylation, the IKK complex phosphorylates IkBa on Ser32 and Ser36, which is subsequently ubiquitinated and degraded via the proteasome pathway

Go back
591.0, 583.0
25.0, 25.0

p18

p18

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e30 e103

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c223 : 1
stoichiometry:c48 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 16723122 Once activated by phosphorylation, the IKK complex phosphorylates IkBa on Ser32 and Ser36, which is subsequently ubiquitinated and degraded via the proteasome pathway PMID: 16723122 They showed that, whereas NAC and PDTC efficiently blocked TNF-induced IkBa degradation and NF-kB activation,the more potent antioxidants epigallocatechin-gallate (EGCG) and Vitamin E analog Trolox failed to inhibit TNF-stimulated NF-kB activation, suggesting that the effect of NAC and PDTC on NF-kB signalling does not rely on their antioxidant capacities, but rather acts by inhibiting a crucial step in TNF signalling. PMID: 16723122 PDTC is likely to inhibit IkB-ubiquitin ligase activity.

Go back
392.0, 756.0
23.0, 23.0

p19

p19

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e31 e102

e15 e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c222 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 16723122 Once activated by phosphorylation, the IKK complex phosphorylates IkBa on Ser32 and Ser36, which is subsequently ubiquitinated and degraded via the proteasome pathway PMID: 16723122 They showed that, whereas NAC and PDTC efficiently blocked TNF-induced IkBa degradation and NF-kB activation,the more potent antioxidants epigallocatechin-gallate (EGCG) and Vitamin E analog Trolox failed to inhibit TNF-stimulated NF-kB activation, suggesting that the effect of NAC and PDTC on NF-kB signalling does not rely on their antioxidant capacities, but rather acts by inhibiting a crucial step in TNF signalling.

Go back
375.0, 371.0
26.0, 26.0

p1

p2

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e9

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1

m9*0.1

nodelay

--

true

0

false

PMID: 16723122,6254151 ROS are generated through multiple sources in the cell, such as the electron transport chain in mitochondria, ionizing radiations and through enzymes producing superoxide anion such as phagocytic and non-phagocytic NADPH oxidases , lipoxygenases and cycloxygenases.

Go back
505.0, 765.0
21.0, 21.0

p20

p20

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e15

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 16723122 The freed NF-kB then translocates into the nucleus where it activates the transcription of target genes such as cytokines, chemokines, adhesion molecules and inhibitors of apoptosis

Go back
328.0, 892.0
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16723122 The freed NF-kB then translocates into the nucleus where it activates the transcription of target genes such as cytokines, chemokines, adhesion molecules and inhibitors of apoptosis

Go back
356.0, 924.0
23.0, 23.0

p21

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16723122 The freed NF-kB then translocates into the nucleus where it activates the transcription of target genes such as cytokines, chemokines, adhesion molecules and inhibitors of apoptosis

Go back
388.0, 960.0
23.0, 23.0

p21

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16723122 The freed NF-kB then translocates into the nucleus where it activates the transcription of target genes such as cytokines, chemokines, adhesion molecules and inhibitors of apoptosis

Go back
496.0, 976.0
23.0, 23.0

p21

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16723122 The freed NF-kB then translocates into the nucleus where it activates the transcription of target genes such as cytokines, chemokines, adhesion molecules and inhibitors of apoptosis

Go back
752.0, 600.0
24.0, 24.0

p25

p25

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

MO000000202 MO000000210 MO000000203 e38

MO000000196

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c67 : 1

m173*m181*m174*m38*0.1

nodelay

--

true

0

false

PMID: 16723122,12352969 It is induced by B-cell activating factor (BAFF) , lymphotoxin b (LTb), CD40 ligand and human T cell leukemia (HTLV) and Epstein-Barr (EBV) virus. It enhances NF-kB inducing kinase (NIK)- and IKKa-dependent processing of p100 into p52, which binds DNA in association with its partners, like RelB.

Go back
608.0, 188.0
23.0, 23.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000211 MO000000210 MO000016599

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m182*m181*m1593*0.1

nodelay

--

true

0

false

PMID: 16723122,9657155,9346241 Whereas all these NF-kB inducers signal through different receptors and adaptor proteins, they all converge to the activation of the so called IkB-kinase (IKK) complex, which includes the scaffold protein NF-kB essential modulator (NEMO, also called IKKg, IKKa and IKKb kinases.

Go back
829.0, 729.0
22.0, 22.0

p25

p27

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

MO000000202 MO000000203 MO000000210 e39

MO000000196

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c72 : 1

m173*m174*m181*m39*0.1

nodelay

--

true

0

false

PMID: 16723122,12387745 It is induced by B-cell activating factor (BAFF) , lymphotoxin b (LTb), CD40 ligand and human T cell leukemia (HTLV) and Epstein-Barr (EBV) virus. It enhances NF-kB inducing kinase (NIK)- and IKKa-dependent processing of p100 into p52, which binds DNA in association with its partners, like RelB.

Go back
909.0, 737.0
22.0, 22.0

p25

p28

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

MO000000202 MO000000203 MO000000210 e40

MO000000196

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c74 : 1

m173*m174*m181*m40*0.1

nodelay

--

true

0

false

PMID: 16723122,12374738 It is induced by B-cell activating factor (BAFF) , lymphotoxin b (LTb), CD40 ligand and human T cell leukemia (HTLV) and Epstein-Barr (EBV) virus. It enhances NF-kB inducing kinase (NIK)- and IKKa-dependent processing of p100 into p52, which binds DNA in association with its partners, like RelB.

Go back
601.0, 765.0
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000194 MO000000196

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m167*m168*0.1

nodelay

--

true

0

false

PMID: 16723122 It enhances NF-kB inducing kinase (NIK)- and IKKa-dependent processing of p100 into p52, which binds DNA in association with its partners, like RelB.

Go back
223.0, 527.0
26.0, 26.0

p1

p3

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e11

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16723122,10029572,10488060,12147646 ROS are generated through multiple sources in the cell, such as the electron transport chain in mitochondria, ionizing radiations and through enzymes producing superoxide anion such as phagocytic and non-phagocytic NADPH oxidases , lipoxygenases and cycloxygenases.

Go back
688.0, 928.0
24.0, 24.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 16723122 It enhances NF-kB inducing kinase (NIK)- and IKKa-dependent processing of p100 into p52, which binds DNA in association with its partners, like RelB.

Go back
576.0, 1024.0
23.0, 23.0

p31

p31

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e42 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m42*m43*0.1

nodelay

--

true

0

false

PMID: 16723122 It enhances NF-kB inducing kinase (NIK)- and IKKa-dependent processing of p100 into p52, which binds DNA in association with its partners, like RelB.

Go back
864.0, 816.0
23.0, 23.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 e16

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m45*m16*0.1

nodelay

--

true

0

false

PMID: 16723122,15592513 a recent study in Jurkat leukemic cells has shown that NF-kB activation by H2O2 induces Bfl-1, which, in turn, attenuates Fas-mediated apoptosis

Go back
545.0, 981.0
22.0, 22.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16723122,15592513 a recent study in Jurkat leukemic cells has shown that NF-kB activation by H2O2 induces Bfl-1, which, in turn, attenuates Fas-mediated apoptosis

Go back
691.0, 587.0
25.0, 25.0

p34

p34

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e47 e30

e15 e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m47*m30*0.1

nodelay

--

true

0

false

PMID: 16723122,10754328 Furthermore, the IkBa degradation mechanism appears to be proteasome-independent, but instead relies on a calpain-mediated digestion after phophorylation on S/T in the so-called PEST sequence of the inhibitor

Go back
279.0, 575.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48 e16 e45 MO000017772 e7 e102 e117 e116

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c276 : 1
stoichiometry:c277 : 1
stoichiometry:c288 : 1
stoichiometry:c100 : 1

m48*m16*m45*m2529*m7*0.1

nodelay

--

true

0

false

PMID: 16723122,11231305,8797825 NF-kB activation induced by tyrosine phosphorylation of IkBa was also observed after pervanadate (a potent tyrosine phosphatase inhibitor) and hypoxia/reoxygenation treatment PMID: 16723122,11231305 TCR-associated tyrosine kinases p56Lck and ZAP-70 were required for pervanadate-induced IkBa tyrosine phosphorylation, without showing that these kinases indeed phosphorylate IkBa directly PMID: 16723122,12429743 In that case, the tyrosine kinase c-Src has been reported to be responsible for IkBa tyrosine phosphorylation

Go back
388.0, 516.0
23.0, 23.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000008301 e30

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m1066*m30*0.1

nodelay

--

true

0

false

PMID: 16723122,12711606 Recently,Takada et al. reported that Syk tyrosine kinase was required for H2O2-induced IkBa tyrosine phosphorylation and NF-kB activation, and was capable of phosphorylating IkBa in vitro, suggesting that Syk may be the terminal tyrosine kinase responsible for IkBa tyrosine phosphorylation

Go back
777.0, 389.0
21.0, 21.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 MO000000248

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m45*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,16619039 Unexpectedly, micromolar amounts of H2O2 were shown indeed capable of inducing IKK activation in these cell lines, leading to a classical IkBa phosphorylation on Ser32 and 36

Go back
295.0, 295.0
25.0, 25.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e49 e16

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m49*m16*0.1

nodelay

--

true

0

false

PMID: 16723122,16619039 Unexpectedly, micromolar amounts of H2O2 were shown indeed capable of inducing IKK activation in these cell lines, leading to a classical IkBa phosphorylation on Ser32 and 36

Go back
788.0, 976.0
23.0, 23.0

p39

p39

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e63 MO000017583

e64 e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m63*m347277*0.1

nodelay

--

true

0

false

PMID: 16723122,10995586 SHIP-1, a lipid phosphatase, acts by dephosphorylating the membranebound PtdIns(3,4,5)P3, generated by PI3Kinase, and has thus been described as a negative regulator of immune receptor, cytokine and growth factor receptor signalling

Go back
335.0, 475.0
26.0, 26.0

p1

p4

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e12

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 16723122,10029572,10488060,12147646 ROS are generated through multiple sources in the cell, such as the electron transport chain in mitochondria, ionizing radiations and through enzymes producing superoxide anion such as phagocytic and non-phagocytic NADPH oxidases , lipoxygenases and cycloxygenases.

Go back
852.0, 896.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000000030

MO000017583

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 16723122,10995586 SHIP-1, a lipid phosphatase, acts by dephosphorylating the membranebound PtdIns(3,4,5)P3, generated by PI3Kinase, and has thus been described as a negative regulator of immune receptor, cytokine and growth factor receptor signalling

Go back
540.0, 808.0
23.0, 23.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m45*m67*0.1

nodelay

--

true

0

false

PMID: 16723122 First, activated Src induces Abl-mediated phophorylation of PKD at Y463 in the PH domain.

Go back
359.0, 811.0
25.0, 25.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e67 e68 MO000078383

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m68*m69*m53120*0.1

nodelay

--

true

0

false

PMID: 16723122 First, activated Src induces Abl-mediated phophorylation of PKD at Y463 in the PH domain.This facilitates release of the PH domain, which exposes the catalytic domain and activation loop residues to a second phosphorylation by PKCd on S738/S742. This induces a fully activated PKD which, in turn, activates the IKK complex

Go back
176.0, 868.0
23.0, 23.0

p43

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e69 MO000017065

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m70*m1957*0.1

nodelay

--

true

0

false

PMID: 16723122 First, activated Src induces Abl-mediated phophorylation of PKD at Y463 in the PH domain.This facilitates release of the PH domain, which exposes the catalytic domain and activation loop residues to a second phosphorylation by PKCd on S738/S742. This induces a fully activated PKD which, in turn, activates the IKK complex

Go back
568.0, 392.0
24.0, 24.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 MO000000248

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m71*m207*0.1

nodelay

--

true

0

false

PMID: 16723122 First, activated Src induces Abl-mediated phophorylation of PKD at Y463 in the PH domain.This facilitates release of the PH domain, which exposes the catalytic domain and activation loop residues to a second phosphorylation by PKCd on S738/S742. This induces a fully activated PKD which, in turn, activates the IKK complex

Go back
641.0, 429.0
21.0, 21.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e19 e16 e71 e73 e82

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c142 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c138 : 1

m19*m16*0.1

nodelay

--

true

0

false

PMID: 16723122,11479295 Korn et al. reported that, in this case, H2O2 is capable of inhibiting TNF-induced NF-kB activation in lung epithelial cells by reducing IKKb activity through oxidation of cysteine residues in the IKK complex PMID: 16723122,16344117 Other works demonstrated that ammonia monochloramine (NH2Cl) and glycine chloramine (GlyCl), two others neutrophils-derived oxidants, but not TauCl, were capable of inhibiting TNFinduced NF-kB activation via the same molecular mechanism

Go back
827.0, 539.0
25.0, 25.0

p47

p47

cso30:i:ME_Oxidation

cso30:i:CC_Cell_WithoutCellWall_

--

e45 MO000000248

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m45*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,11479295 Korn et al. reported that, in this case, H2O2 is capable of inhibiting TNF-induced NF-kB activation in lung epithelial cells by reducing IKKb activity through oxidation of cysteine residues in the IKK complex

Go back
1076.0, 976.0
23.0, 23.0

p48

p48

cso30:i:ME_UnknownInteraction

cso30:i:CC_Extracellular

--

e45 e72 e13

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c145 : 1

m45*m73*m13*0.1

nodelay

--

true

0

false

PMID: 16723122,9787133 HOCl is formed from H2O2 and Cl ion by myeloperoxidase

Go back
1077.0, 1133.0
21.0, 21.0

p49

p49

cso30:i:ME_UnknownInteraction

cso30:i:CC_Cell_WithoutCellWall_

--

e74 e75

e76 e77 e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c157 : 1

m75*m76*0.1

nodelay

--

true

0

false

PMID: 16723122,10333500 HOCl is a strong oxidant that kills phagocytosed bacteria, but can also react with amines to produce chloramines and N-chlorinated derivatives which have long lifetimes PMID: 16723122 Among these chloramines, taurine chloramine (TauCl) is generated in great amount in HOClproducing neutrophils because these cells contain high concentrations of taurine, a free amino acid not incorporated in proteins.

Go back
765.0, 1093.0
22.0, 22.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e111 MO000000023 e15 e102 e14

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c244 : 1
stoichiometry:c249 : 1
stoichiometry:c250 : 1
stoichiometry:c251 : 1
stoichiometry:c248 : 1

m113*m111*0.1

nodelay

--

true

0

false

PMID: 16723122 In fact, several laboratories have independently reported that NF-kB down-regulates JNK activation by suppressing TNF-induced ROS accumulation PMID: 16723122 Moreover, prolonged JNK activation is inhibited by pre-treatment of NF-kB-defective cells with the antioxidants BHA or NAC, suggesting that ROS are key messengers of prolonged JNK activation after TNF induction.

Go back
181.0, 37.0
21.0, 21.0

p84

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID:16723122,1698311,7681082,2402637 CD14, which is expressed on the surface and in the cytoplasm (sCD14) of monocytes/macrophages and neutrophils, has also been reported to play a key role in the recognition of LPS and in downstream cytokine release, notably through its interaction with LPS-binding protein (LBP), which binds the lipid A region of LPS and aids LPS to dock at the TLR4

Go back
491.0, 259.0
25.0, 25.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e78 e16 e79

e15 e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c158 : 1
stoichiometry:c156 : 1
stoichiometry:c159 : 1

m79*m16*0.1

nodelay

--

true

0

false

PMID: 16723122,11490015 For example, TauCl was shown to decrease LPSinduced NF-kB activation and IKK activity in alveolar macrophages, resulting in inhibition of iNOS and TNFa gene expression

Go back
531.0, 287.0
25.0, 25.0

p51

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e78 MO000000248 e79

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c163 : 1
stoichiometry:c162 : 1

m79*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,11490015 For example, TauCl was shown to decrease LPSinduced NF-kB activation and IKK activity in alveolar macrophages, resulting in inhibition of iNOS and TNFa gene expression

Go back
380.0, 1088.0
23.0, 23.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16723122,11490015 For example, TauCl was shown to decrease LPSinduced NF-kB activation and IKK activity in alveolar macrophages, resulting in inhibition of iNOS and TNFa gene expression

Go back
448.0, 1092.0
23.0, 23.0

p53

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16723122,11490015 For example, TauCl was shown to decrease LPSinduced NF-kB activation and IKK activity in alveolar macrophages, resulting in inhibition of iNOS and TNFa gene expression

Go back
336.0, 432.0
23.0, 23.0

p55

p55

cso30:i:ME_Oxidation

cso30:i:CC_Extracellular

--

e17

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 16723122,11983684 The molecular mechanism of this inhibition relied on oxidation of IkBa methionine 45, which renders the inhibitor resistant to TNF-induced degradation

Go back
822.0, 1134.0
27.0, 27.0

p56

p56

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cell_WithoutCellWall_

--

e19 e79 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1

m19*m80*0.1

nodelay

--

true

0

false

PMID: 16723122,11983684 The molecular mechanism of this inhibition relied on oxidation of IkBa methionine 45, which renders the inhibitor resistant to TNF-induced degradation

Go back
1076.0, 1424.0
23.0, 23.0

p57

p57

cso30:i:ME_UnknownInteraction

cso30:i:CC_Cell_WithoutCellWall_

--

e84 e85

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m85*m86*0.1

nodelay

--

true

0

false

PMID: 16723122,2154753 Peroxinitrite is formed by the reaction of nitric oxide (NO) with superoxide

Go back
669.0, 1301.0
22.0, 22.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e111 MO000000166

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m113*m146*0.1

nodelay

--

true

0

false

PMID: 16723122 Using blocking antibodies, they also reported that the ROS-dependent Rac1 activation is independent of the CD14 receptor, suggesting that alternative pathways contribute to NF-kB activation by LPS

Go back
397.0, 25.0
21.0, 21.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e87 e21

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m88*m21*0.1

nodelay

--

true

0

false

PMID: 16723122,9374458,9371760,10854325 IL-1b is a potent pro-inflammatory cytokine that exerts its effects by binding to its receptor (IL1-R1) on the plasma membrane. This binding induces the recruitment to the receptor cytoplasmic tail of adaptator and effector proteins, including IL-1RacP, MyD88 and Tollip

Go back
435.0, 347.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 e17

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m15*m17*0.1

nodelay

--

true

0

false

PMID: 16723122 In the resting state, NF-kB is sequestered in the cytoplasm of the cell through its tight associationwith inhibitory proteins called IkBs

Go back
305.0, 209.0
21.0, 21.0

p59

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e88 MO000016573

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m89*m1572*0.1

nodelay

--

true

0

false

PMID: 16723122,9374458,9371760,10854325 IL-1b is a potent pro-inflammatory cytokine that exerts its effects by binding to its receptor (IL1-R1) on the plasma membrane. This binding induces the recruitment to the receptor cytoplasmic tail of adaptator and effector proteins, including IL-1RacP, MyD88 and Tollip

Go back
193.0, 201.0
21.0, 21.0

p59

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e89 MO000019406

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m90*m3973*0.1

nodelay

--

true

0

false

PMID: 16723122,9374458,9371760,10854325 IL-1b is a potent pro-inflammatory cytokine that exerts its effects by binding to its receptor (IL1-R1) on the plasma membrane. This binding induces the recruitment to the receptor cytoplasmic tail of adaptator and effector proteins, including IL-1RacP, MyD88 and Tollip

Go back
188.0, 240.0
20.0, 20.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000213 e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m184*m91*0.1

nodelay

--

true

0

false

PMID: 16723122,9430229,11518704 MyD88 then mediates the recruitment of the interleukin-1 receptorassociated kinase (IRAK) family members to the IL-1R, which, in turn, recruit TRAF6

Go back
180.0, 284.0
24.0, 24.0

p62

p63

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000212 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m183*m92*0.1

nodelay

--

true

0

false

PMID: 16723122,9430229,11518704 MyD88 then mediates the recruitment of the interleukin-1 receptorassociated kinase (IRAK) family members to the IL-1R, which, in turn, recruit TRAF6

Go back
184.0, 332.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e92 MO000016574

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m93*m1573*0.1

nodelay

--

true

0

false

PMID: 16723122,11460167 Then, TRAF6 recruits TAK1 that mediates phosphorylation of the IKK complex, a crucial step in NF-kB activation

Go back
297.0, 365.0
23.0, 23.0

p65

p65

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e93 MO000000248

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m94*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,11460167 Then, TRAF6 recruits TAK1 that mediates phosphorylation of the IKK complex, a crucial step in NF-kB activation

Go back
710.0, 702.0
24.0, 24.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e19 MO000000276

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m19*m219*0.1

nodelay

--

true

0

false

PMID: 16723122 It binds to its cellular TNFR1 receptor, which triggers signalling cascades that activate NF-kB and AP-1 transcription factors.

Go back
1102.0, 234.0
22.0, 22.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000018873

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m18*m3491*0.1

nodelay

--

true

0

false

PMID: 16723122,9915703 The ligation of TNFR1 by trimeric TNFa leads to the aggregation of the receptor and dissociation of silencer of death domain (SODD), an inhibitor of TNFR1 activity, which allows binding of TNFR-associated death domain protein (TRADD protein)

Go back
921.0, 277.0
22.0, 22.0

p67

p68

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e19 MO000000207

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m19*m178*0.1

nodelay

--

true

0

false

PMID: 16723122,9915703 The ligation of TNFR1 by trimeric TNFa leads to the aggregation of the receptor and dissociation of silencer of death domain (SODD), an inhibitor of TNFR1 activity, which allows binding of TNFR-associated death domain protein (TRADD protein)

Go back
888.0, 380.0
23.0, 23.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e96 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m97*m98*0.1

nodelay

--

true

0

false

PMID: 16723122,12787559 Although many members of the TRAF family have been implicated in TNF signalling, it appears that both TRAF2 and TRAF5 have a role in NF-kB activation by TNFa

Go back
1081.0, 193.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000289 e95

e19 MO000018873

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c209 : 1

m230*m96*0.1

nodelay

--

true

0

false

PMID; 16723122,12421671,10795740 The classical NF-kB-activating pathway is induced by a variety of innate and adaptative immunity mediators, such as proinflammatory cytokines (TNFa, IL-1b, Toll-like receptors (TLRs) and antigen receptors (TCR, BCR) ligation PMID: 16723122,9915703 The ligation of TNFR1 by trimeric TNFa leads to the aggregation of the receptor and dissociation of silencer of death domain (SODD), an inhibitor of TNFR1 activity, which allows binding of TNFR-associated death domain protein (TRADD protein)

Go back
912.0, 436.0
23.0, 23.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e99 e98

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m100*m99*0.1

nodelay

--

true

0

false

PMID: 16723122,10755617 RIP1 functions as a scaffold protein notably through its direct binding to NEMO, which allows the recruitment of the IKK complex in TNF signalling

Go back
684.0, 208.0
23.0, 23.0

p70

p71

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e100 MO000016599

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m101*m1593*0.1

nodelay

--

true

0

false

PMID: 16723122,10755617 RIP1 functions as a scaffold protein notably through its direct binding to NEMO, which allows the recruitment of the IKK complex in TNF signalling

Go back
468.0, 760.0
23.0, 23.0

p72

p72

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e31 MO000062257 e103

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c226 : 1
stoichiometry:c227 : 1
stoichiometry:c225 : 1

m31*m37148*0.1

nodelay

--

true

0

false

PMID: 16723122 These results are reinforced by the observation that, whereas NAC does not inhibit IL-1 or TPA-induced IkBa degradation, PDTC does

Go back
24.0, 972.0
23.0, 23.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000214 e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m185*m105*0.1

nodelay

--

true

0

false

PMID: 16723122 These results are reinforced by the observation that, whereas NAC does not inhibit IL-1 or TPA-induced IkBa degradation, PDTC does

Go back
240.0, 840.0
23.0, 23.0

p72

p74

cso30:i:ME_UnknownDegradation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e31 e105 e103

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1
stoichiometry:c300 : 1

m31*m106*0.1

nodelay

--

true

0

false

PMID: 16723122 These results are reinforced by the observation that, whereas NAC does not inhibit IL-1 or TPA-induced IkBa degradation, PDTC does

Go back
597.0, 1133.0
21.0, 21.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45

G011488

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1

1.0*0.1

nodelay

--

true

0

false

PMID:16723122 They showed that ROS (induced by cigarette smoke or H2O2 treatment) reduce HDAC2 expression

Go back
624.0, 1384.0
23.0, 23.0

p76

p76

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell_WithoutCellWall_

--

e102 e10

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c179 : 1
stoichiometry:c238 : 1

m10*0.1

nodelay

--

true

0

false

PMID: 16723122,12368228 Finally, it should also be noted that NAC was shown to inhibit p65 ser536 phosphorylation, suggesting that post-translationalmodifications affecting p65 are also redox-sensitive

Go back
874.0, 1302.0
27.0, 27.0

p77

p77

cso30:i:ME_UnknownInactivation

cso30:i:CC_Cell_WithoutCellWall_

--

e107 MO000017876 e109

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c240 : 1

m108*m2619*m110*0.1

nodelay

--

true

0

false

PMID: 16723122,14743220 In that respect, they identified growth arrest and DNA damage-inducing protein 45b (GADD45b) and X chromosome-linked IAP (XIAP) as capable of inhibiting JNK signalling by inactivating MEKK7

Go back
727.0, 959.0
25.0, 25.0

p78

p78

cso30:i:ME_UnknownProduction

cso30:i:CC_Cell_WithoutCellWall_

--

e101

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c9 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 16723122 They showed that TNFinduced ROS production is responsible for sustained JNK activation in NF-kB-activation deficient cells,whereas wildtype cells exhibited neither ROS production nor sustained JNK activation upon TNF challenge.

Go back
724.0, 1252.0
23.0, 23.0

p77

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000000023 e107 e14 e102 e15

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c247 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c246 : 1

m111*m108*0.1

nodelay

--

true

0

false

PMID: 16723122,14743220 In that respect, they identified growth arrest and DNA damage-inducing protein 45b (GADD45b) and X chromosome-linked IAP (XIAP) as capable of inhibiting JNK signalling by inactivating MEKK7

Go back
745.0, 209.0
21.0, 21.0

p8

p8

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e21 MO000000248

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m21*m207*0.1

nodelay

--

true

0

false

PMID: 16723122,9657155,9346241 Whereas all these NF-kB inducers signal through different receptors and adaptor proteins, they all converge to the activation of the so called IkB-kinase (IKK) complex, which includes the scaffold protein NF-kB essential modulator (NEMO, also called IKKg, IKKa and IKKb kinases.

Go back
434.0, 218.0
20.0, 20.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000016573 e78

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c254 : 1

m1572*m79*0.1

nodelay

--

true

0

false

PMID: 16723122,14751757,: 1475175 Upon binding of TLR4 to LPS, the cytoplasmic region of TLR4 recruits MyD88, which links TLR4 to IRAK and TRAF6 that mediates NF-kB activation

Go back
446.0, 250.0
20.0, 20.0

p80

p81

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000213 e112

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1
stoichiometry:c257 : 1

m184*m114*0.1

nodelay

--

true

0

false

PMID: 16723122 Upon binding of TLR4 to LPS, the cytoplasmic region of TLR4 recruits MyD88, which links TLR4 to IRAK and TRAF6 that mediates NF-kB activation

Go back
442.0, 286.0
20.0, 20.0

p80

p82

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000212 e113

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c259 : 1
stoichiometry:c260 : 1

m183*m115*0.1

nodelay

--

true

0

false

PMID: 16723122 Upon binding of TLR4 to LPS, the cytoplasmic region of TLR4 recruits MyD88, which links TLR4 to IRAK and TRAF6 that mediates NF-kB activation

Go back
320.0, 512.0
23.0, 23.0

p83

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e16 e115 e102 e116 e117 e67

e15 e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c261 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c280 : 1
stoichiometry:c135 : 1
stoichiometry:c263 : 1
stoichiometry:c264 : 1

m16*m117*m68*0.1

nodelay

--

true

0

false

PMID: 16723122 Upon binding of TLR4 to LPS, the cytoplasmic region of TLR4 recruits MyD88, which links TLR4 to IRAK and TRAF6 that mediates NF-kB activation PMID: 16723122,14764725,15039334 Pre-treatment of neutrophils with NAC or atocopherol prevented LPS-induced NF-kB activation and the production of pro-inflammatory cytokines, and NAC and DMSO were reported to block NF-kB activation and IL-8 secretion in monocyte-like THP-1 cells challenged with LPS

Go back
329.0, 49.0
21.0, 21.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019420 MO000016882

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c266 : 1
stoichiometry:c267 : 1

m3985*m155666*0.1

nodelay

--

true

0

false

PMID:16723122,1698311,7681082,2402637 CD14, which is expressed on the surface and in the cytoplasm (sCD14) of monocytes/macrophages and neutrophils, has also been reported to play a key role in the recognition of LPS and in downstream cytokine release, notably through its interaction with LPS-binding protein (LBP), which binds the lipid A region of LPS and aids LPS to dock at the TLR4

Go back
465.0, 53.0
21.0, 21.0

p84

p85

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021929 MO000019394

e78 MO000019420 MO000018132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c268 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c271 : 1
stoichiometry:c272 : 1

m6255*m3961*0.1

nodelay

--

true

0

false

PMID:16723122,1698311,7681082,2402637 CD14, which is expressed on the surface and in the cytoplasm (sCD14) of monocytes/macrophages and neutrophils, has also been reported to play a key role in the recognition of LPS and in downstream cytokine release, notably through its interaction with LPS-binding protein (LBP), which binds the lipid A region of LPS and aids LPS to dock at the TLR4

Go back
192.0, 476.0
24.0, 24.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e114 MO000068593

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c273 : 1
stoichiometry:c274 : 1
stoichiometry:c275 : 1

m116*m43439*0.1

nodelay

--

true

0

false

PMID: 16723122 They showed that, in HEK293T cells, LPS-induced ROS generation and NF-kB activation are mediated by direct interaction of TLR4 with NADPH oxidase 4 (Nox4

Go back
255.0, 1331.0
25.0, 25.0

p88

p88

cso30:i:ME_Ubiquitination

cso30:i:CC_Cell_WithoutCellWall_

--

e119

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c285 : 1

m121*0.1

nodelay

--

true

0

false

PMID: 16723122 Indeed, ROS inactivate MAP kinase phosphatases (MKPs, which are known to suppress JNK activation) by oxidizing critical residues in their phosphatase domain, which leads to prolonged JNK activation (Fig. 5). Moreover, oxidized MKPs are rapidly degraded by the ubiquitin-proteasome pathway

Go back
444.0, 1392.0
23.0, 23.0

p89

p89

cso30:i:ME_Oxidation

cso30:i:CC_Cell_WithoutCellWall_

--

e111 e118

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c282 : 1
stoichiometry:c283 : 1

m113*m120*0.1

nodelay

--

true

0

false

PMID: 16723122 Indeed, ROS inactivate MAP kinase phosphatases (MKPs, which are known to suppress JNK activation) by oxidizing critical residues in their phosphatase domain, which leads to prolonged JNK activation (Fig. 5). Moreover, oxidized MKPs are rapidly degraded by the ubiquitin-proteasome pathway

Go back
773.0, 57.0
21.0, 21.0

p7

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016597 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m1591*m20*0.1

nodelay

--

true

0

false

PMID; 16723122,12421671,10795740 The classical NF-kB-activating pathway is induced by a variety of innate and adaptative immunity mediators, such as proinflammatory cytokines (TNFa, IL-1b, Toll-like receptors (TLRs) and antigen receptors (TCR, BCR) ligation

Go back
190.0, 1266.0
20.0, 20.0

p90

p90

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cell_WithoutCellWall_

--

e120

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c286 : 1
stoichiometry:c287 : 1

m122*0.1

nodelay

--

true

0

false

PMID: 16723122 Indeed, ROS inactivate MAP kinase phosphatases (MKPs, which are known to suppress JNK activation) by oxidizing critical residues in their phosphatase domain, which leads to prolonged JNK activation (Fig. 5). Moreover, oxidized MKPs are rapidly degraded by the ubiquitin-proteasome pathway

Go back
721.0, 1209.0
21.0, 21.0

p93

p93

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e111 MO000000079 MO000000212

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1

m113*m128*m183*0.1

nodelay

--

true

0

false

PMID: 16723122,15864310 It should, however, be noted that ROS production after LPS challenge has been showed to mediate the formation of a complex between TRAF6 and the redox-sensitive ASK1, which, in turn, triggers p38 activation, another downstream target of LPS signalling

Go back
337.0, 1317.0
21.0, 21.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e126 e127

MO000000022

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c298 : 1
stoichiometry:c299 : 1

m129*m131*0.1

nodelay

--

true

0

false

PMID: 16723122,15864310 It should, however, be noted that ROS production after LPS challenge has been showed to mediate the formation of a complex between TRAF6 and the redox-sensitive ASK1, which, in turn, triggers p38 activation, another downstream target of LPS signalling

Go back
312.0, 820.0
24.0, 24.0

p95

p95

cso30:i:ME_UnknownProduction

cso30:i:CC_Cell_WithoutCellWall_

--

e115

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c302 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 16723122,15864310 It should, however, be noted that ROS production after LPS challenge has been showed to mediate the formation of a complex between TRAF6 and the redox-sensitive ASK1, which, in turn, triggers p38 activation, another downstream target of LPS signalling

Go back
212.98146954145233, 417.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 1042.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
304.0, 595.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 545.8552133238443

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
418.99065116865603, 529.3866444113866

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.0, 539.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
798.165118323207, 416.83021151602827

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
702.0, 278.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.5952062052854, 350.5280520215392

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
327.9794452002007, 309.57310932377135

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
326.7061927028833, 320.3619925987781

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
314.0, 320.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.73299699339486, 379.810039783566

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.0, 923.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.7580256148958, 948.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.0, 990.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.0, 995.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.0, 863.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
875.0, 912.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.0, 1278.9643929394745

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
63.0, 524.0

c117

c117

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
532.0, 731.0

c118

c118

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
570.9275991872017, 822.0738580572305

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.91203237485325, 342.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.1570394041597, 783.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.9930645847388, 816.3330443576974

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.96903880020307, 817.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 737.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 763.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.88625372827516, 808.3442477945923

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.34500298894304, 819.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
192.0, 754.5381544149095

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
177.0, 766.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
255.0, 421.5547862828213

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.0, 372.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.9908691360604, 278.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 348.05950785153817

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
311.47559059905353, 595.8487795975368

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
193.0, 538.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
212.0, 578.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.2050885579831, 542.329898180431

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.2636750760037, 273.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
575.0, 446.6326040130368

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.2360481182217, 450.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.7175610316242, 570.4610074998332

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1092.0, 154.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.0, 278.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.73801616163, 514.0305432480873

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.1333845640696, 453.8360708322356

c142

c142

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1088.0, 905.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1104.488102949512, 941.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.0, 999.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.0, 998.8724910813381

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1088.0, 1075.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1102.1576223972818, 1050.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 1149.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.0, 167.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 1134.796029752168

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
209.682769814029, 53.23048155891164

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
171.0, 65.76703727585462

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.0, 58.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 179.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.1738325617825, 291.6989903229796

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 284.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1088.0, 1154.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.0783946159197, 287.41764185082576

c158

c158

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
375.64837595740437, 284.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1040.7811348571815, 214.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 179.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.7685735448305, 267.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 303.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.0169062772428, 315.4542856090397

c163

c163

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
377.1808595010744, 1111.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.3013211042405, 907.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.9446950007509, 907.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.0, 1115.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.30323471489646, 346.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0, 452.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.0, 68.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.6686348824677, 290.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.5823503013634, 1154.5510711294307

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0, 1156.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 686.0

c173

c173

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
571.0, 93.0

c174

c174

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
652.0, 94.0

c175

c175

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1091.4103928022648, 1357.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.0955145420758, 1410.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.0, 1447.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.9936076697743, 1392.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.0, 84.26996701210007

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.9373322778883, 1150.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
907.0509053796171, 1332.2332154634528

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
373.0, 53.29734956888553

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.9999995167932, 36.00278052307259

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.65685424949237, 46.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.0, 157.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 220.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.63005780346822, 166.40462427745663

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.0, 168.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.78063113323532, 215.86058570577367

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 78.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.0, 212.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.97056446268277, 251.68563995377917

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
152.0, 220.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
151.0898035516947, 255.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.0, 296.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
144.0, 287.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.65685424949237, 308.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.0, 346.8834522085988

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.0, 344.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
145.53524290588493, 355.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.0, 433.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.0, 72.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
140.0, 381.64557063413986

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
327.6708170829599, 268.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 377.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.4923995290986, 285.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.0, 733.5458827133112

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 726.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1046.0, 218.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 225.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1034.010539483953, 175.2795279250937

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.9354386776247, 205.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.0, 85.99756038043539

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.8224193126193, 271.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 306.62584510159456

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
943.0, 293.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
918.197664894929, 338.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 381.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
911.0, 388.3262589561145

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.0, 464.3813823519705

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.7942826023124, 395.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 438.01731452788295

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.6764739922177, 231.40734557656202

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.6707771379567, 82.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.0, 216.0

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.0, 231.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
68.0, 524.0

c222

c222

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
66.0, 602.4610732907234

c223

c223

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
481.53570761289916, 611.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.65685424949237, 678.6568542494924

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
63.0, 730.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
66.0, 773.4058548150207

c227

c227

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
37.371691194819746, 929.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
53.629791060287616, 925.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 507.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
47.0, 986.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.4774036933124, 609.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
148.0, 869.3120308331415

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
66.0, 820.0

c233

c233

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
621.5405315861128, 904.0

c234

c234

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
590.9115249081194, 1154.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
60.0, 524.0

c236

c236

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
686.5473835124583, 1042.0

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.9430147078954, 1397.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 1304.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1041.0, 511.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 1316.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.0, 1276.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 1315.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
758.0307778752851, 738.0

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.9062958577988, 1121.9814649373425

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.1175644130494, 1219.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.0, 1249.8437524961075

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.410363207638, 1272.0143850336156

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.0, 1115.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 731.0

c249

c249

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1043.9921104517296, 553.3552049089658

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
66.0, 524.0

c250

c250

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
699.0, 1118.939965457649

c251

c251

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
401.0, 222.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.4376015698018, 173.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 162.97590602738106

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 260.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.95238969223203, 163.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.0, 155.1455217009899

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.0, 296.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.3206812385497, 153.0

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.0, 607.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.83313959465474, 302.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
136.0, 539.0950515759703

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
350.80219390040713, 475.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 535.0

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
335.0, 535.0

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.0, 23.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.7546727037216, 64.9659733615069

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.8587085313798, 62.0

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 70.95733959101388

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.0, 80.71933334797251

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1041.0, 621.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.0, 74.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.6484336655659, 17.345519657440203

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
188.72123901359518, 67.0

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.0, 488.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 508.0

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.8461960238195, 500.0

c275

c275

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
73.0, 519.0

c276

c276

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
63.0, 602.9989970651461

c277

c277

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
73.0, 513.0

c278

c278

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
52.0, 538.5504072953569

c279

c279

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1039.9921104517296, 665.3552049089658

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
63.0, 538.0728851183895

c280

c280

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
471.1862373901281, 1042.0

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.0, 1410.2987830845307

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.94884203831776, 1393.9032775043543

c283

c283

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
286.81326653363635, 1356.1927794053147

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 1344.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
201.34749779421045, 1293.9924492668404

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 680.7205091212081

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
52.0, 603.5699650216014

c288

c288

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
769.9304660932648, 163.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.7749876778742, 1042.0

c293

c293

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.9861949854, 1217.0

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 309.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.9272325009983, 1230.0

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.87542060406787, 1331.4063251078692

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.65685424949237, 1343.6568542494924

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
307.037652108609, 1305.8041362749238

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.0, 303.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 231.55367983064247

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 679.8454337514103

c300

c300

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
136.0, 704.0

c301

c301

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.0, 837.0

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.3272349257431, 230.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.5503162554905, 160.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 232.95561940260848

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0246265540005, 238.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 265.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.3577034485445, 284.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.9909451017955, 269.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
880.405525702975, 443.7926235475496

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 278.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.37673718523206, 394.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.7577479408573, 396.9538031851048

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.4928696182884, 511.67361146437185

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.0, 278.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0699613359017, 412.1883351599976

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.5909734841225, 406.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
575.0, 481.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
569.952686327183, 538.8687808592721

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 551.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 596.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.67538335099016, 611.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.49722631176357, 560.6002539923239

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
415.0, 729.903356427536

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.5572042599299, 680.5802840562209

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.8323146698044, 731.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.0130708141196, 786.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.98913371065026, 897.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.2839333778203, 914.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.56298385301017, 902.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0698344970131, 947.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.9415075534005, 907.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.30184301687433, 983.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 506.5339352927587

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
487.0, 907.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0, 999.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.0, 213.83509185099385

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.3423947843869, 218.88656935827302

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 210.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.0, 203.49689686311996

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 619.915194788644

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 624.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.0, 285.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.5492597919182, 624.5942568689576

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.0, 488.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.5744836667934, 618.5743343181258

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.0, 654.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.9726042969965, 746.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0, 652.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.8277488213334, 750.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
844.9402850002907, 689.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
867.0, 689.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 285.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 285.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.9195959492894, 743.1313708498985

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
290.9940893970505, 485.3074649768096

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
938.1352054419444, 757.6178506466197

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.1313708498985, 730.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.9963843848783, 776.240492763455

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 786.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.0, 885.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.9861949854, 933.4697761756117

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 949.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
606.1057411452476, 1015.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 1046.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
894.6554714273235, 833.3224463880645

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
747.0, 984.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 489.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.6405130944898, 727.3711937189796

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 907.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.0, 1003.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.8831183444133, 584.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
562.0, 542.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.6079289585086, 609.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.8762070493361, 602.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
77.0, 591.4413666296701

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
311.33896903202566, 478.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back