1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16753195.csml convertedTime:2009.07.01.10:55

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Innate immune responses: crosstalk of signaling and regulation of genetranscription.
Authors Zhong B, Tien P, Shu HB.
Affiliation College of Life Sciences, Wuhan University, Wuhan 430072, China.
Abstract Innate immune responses to pathogens such as bacteria and viruses are triggeredby recognition of specific structures of invading pathogens calledpathogen-associated molecular patterns (PAMPs) by cellular pattern recognitionreceptors (PRRs) that are located at plasma membrane or inside cells.Stimulation of different PAMPs activates Toll-like receptor (TLR)-dependent and-independent signaling pathways that lead to activation of transcription factorsnuclear factor-kappaB (NF-kappaB), interferon regulatory factor 3/7 (IRF3/7)and/or activator protein-1 (AP-1), which collaborate to induce transcription ofa large number of downstream genes. This review focuses on the rapid progressthat has recently improved our understanding of the crosstalk among the pathwaysand the precise regulation of transcription of the downstream genes.
PMID 16753195
Model Abstract

Entity

G010329:TNF-alpha MO000000023:JNK MO000000058:NF-kappaB MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK MO000000215:IkappaB MO000000248:IKK MO000000276:AP-1 MO000000289:TNF-alpha MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016608:IKK-i MO000016882:LPS MO000016899:FADD MO000019331:TBK1 MO000019348:MyD88 MO000019394:TLR4 MO000019398:TLR3 MO000020434:Nod1 MO000020461:Nod2 MO000022125:TAB2 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042032:PGN MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e11: e12: e13:CpG motif e14:TLR9:CpGmotif e15:CpGmotif:TLR9:MyD88 e16:CpGmotif:TLR9:MyD88:IRAK-4 e17:CpGmotif:TLR9:MyD88:IRAK-4:IRAK e18:CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p} e19:CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p} e2: e20:CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p}:TRAF6 e21:IRAK:TRAF6 e22:TAK1:TAB1:TAB2 e23:IRAK:TRAF6:TAK1:TAB1:TAB2 e24:IRAK:TRAF6:TAK1{p}:TAB1:TAB2 e25:IKK{active} e26:IkappaB{p} e27:NF-kappaB{active} e28:JNK{active} e29:AP-1{active} e3: e30:Nod1:PGN e31:Nod2:PGN e33:DDX58:dsRNA e34:IFIH1:dsRNA e35:DDX58:dsRNA:MAVS e36:GR e37:Ligand e38:GR:Ligand e39:Scyb9 e4: e40:IP10 e41:dsRNA:TLR3:TRIF e42:dsRNA:TLR3:TRIF:TBK1 e43:dsRNA:TLR3:TRIF:IKK-i e44:dsRNA:TLR3:TRIF:IKK-beta e45:dsRNA:TLR3:TRIF:TRAF6 e46:IRF-3{p} e47:IRF-7{p} e48:IFIH1:dsRNA:MAVS e49:LPS:TLR4:TRAM e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:LPS:TLR4:TRAM:TRIF e64:LPS:TLR4:TRAM:TRIF:IKK-i e65:LPS:TLR4:TRAM:TRIF:TBK1 e66:LPS:TLR4:TRAM:TRIF:IKK-beta e67:RIP1 e68:LPS:TLR4:TRAM:TRIF:RIP1 e69:dsRNA:TLR3:TRIF:RIP1 e7: e70:DDX58:dsRNA:MAVS:RIP1:FADD e71:IFIH1:dsRNA:MAVS:RIP1:FADD e72:LPS:TLR4:TIRAP e73:LPS:TLR4:TIRAP:MyD88 e74:LPS:TLR4:TIRAP:MyD88:IRAK-4 e75:LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK e76:LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p} e77:LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p} e78:LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p}:TRAF6 e79:DDX58:dsRNA:MAVs:TRAF6 e8: e80:IFIH1:dsRNA:MAVS:TRAF6 e81:IFIH1:dsRNA:MAVS:TRAF6:TAK1 e82:DDX58:dsRNA:MAVs:TRAF6:TAK1 e83:TNF-alphaR e84:TNF-alpha:TNF-alphaR e85:cytokines e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p9
Model Detail
456.0, 1012.0
24.0, 24.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
787.0, 831.0
18.0, 18.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
342.0, 970.0
20.0, 20.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p21 p22 p61 p62 p66 p68 p69 p72

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
460.0, 544.0
24.0, 24.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p44

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
518.0, 594.0
20.0, 20.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p34 p59 p63 p64

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
562.0, 422.0
19.0, 19.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p56

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
241.0, 773.0
22.0, 22.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
408.0, 752.0
23.0, 23.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
848.0, 884.0
24.0, 24.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
102.0, 1054.0
20.0, 20.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

p71

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
304.0, 572.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p36 p49 p50 p74 p76

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
240.0, 476.0
24.0, 24.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p38 p47 p48 p73 p75

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
585.0, 489.0
60.0, 60.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

--

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
561.0, 697.0
29.0, 29.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p65 p67

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
587.0, 663.0
18.0, 18.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
500.0, 424.0
24.0, 24.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p42

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
345.0, 97.0
21.0, 21.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
435.0, 1275.0
18.0, 18.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
858.0, 654.0
20.0, 20.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p43

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
600.0, 212.0
23.5, 23.5

MyD88

--

MO000019348

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p54

true true true true

csml-variable:Double

m332813

10

false

infinite

0

unit false false false
Affymetrix209124_at
EnsemblENSG00000172936
HGNCMYD88
InterProIPR000157
OMIM602170
ProteomeHumanPSD/MYD88
RefSeqNM_002468
TRANSPATHMO000019348
UnigeneHs.82116
UniProtQ99836

--

Go back
347.0, 159.0
18.5, 18.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
921.0, 341.0
22.0, 22.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
370.0, 1370.0
20.0, 20.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
230.0, 1242.0
20.5, 20.5

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
580.0, 748.0
16.0, 16.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
1091.0, 391.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p23 p24

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
427.0, 215.0
18.0, 18.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
535.0, 351.0
18.5, 18.5

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p55

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
962.0, 558.0
19.0, 19.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p41

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
218.0, 246.0
19.0, 19.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
928.0, 416.0
24.0, 24.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p28 p30

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
877.0, 297.0
22.0, 22.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
255.0, 1359.0
17.5, 17.5

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
929.0, 1061.0
21.0, 21.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
785.0, 1245.0
22.0, 22.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p39

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
938.0, 1226.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
140.75, 131.9969080091176
925.7738673448592, 1344.2236553847338

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
148.0, 163.0
911.6568274719592, 1282.4448124200799

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
743.1927256177347, 260.0
224.7936586198395, 375.29110803481643

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
743.1927256177347, 260.0
224.7936586198395, 375.29110803481643

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
850.0, 100.0
60.0, 16.0

CpG motif

--

e13

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
783.5, 263.0
17.33172549879412, 33.545275158956365

TLR9:CpGmotif

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
757.5, 301.0
21.488162965681788, 29.983483207928078

CpGmotif:TLR9:MyD88

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
774.0, 380.0
19.058823529411764, 31.764705882352942

CpGmotif:TLR9:MyD88:IRAK-4

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5 p10

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
770.0, 444.0
19.058823529411764, 31.764705882352942

CpGmotif:TLR9:MyD88:IRAK-4:IRAK

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
766.0, 496.0
19.058823529411764, 31.764705882352942

CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
762.0, 564.0
19.058823529411764, 31.764705882352942

CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p}

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
140.75, 131.9969080091176
925.7738673448592, 1344.2236553847338

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
842.0, 604.0
19.058823529411764, 31.764705882352942

CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p}:TRAF6

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
850.5, 732.0
19.253791034827522, 23.57607065489085

IRAK:TRAF6

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10 p60

p12

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
706.5, 662.0
19.79152138006974, 27.616076344283357

TAK1:TAB1:TAB2

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
831.0, 805.0
18.176470588235297, 30.294117647058822

IRAK:TRAF6:TAK1:TAB1:TAB2

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
579.0, 793.0
18.176470588235297, 30.294117647058822

IRAK:TRAF6:TAK1{p}:TAB1:TAB2

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14 p15

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
360.0, 800.0
23.0, 23.0

IKK{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p16

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
301.0, 909.0
22.0, 22.0

IkappaB{p}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p17

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
265.0, 1033.0
22.0, 22.0

NF-kappaB{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p21 p22 p61 p62 p66 p68 p69 p72

p77

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
779.0, 911.0
18.0, 18.0

JNK{active}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p18

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
848.0, 1012.0
24.0, 24.0

AP-1{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p80

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
159.26547734689714, 150.5123853560148
888.742912651065, 1307.1927006909407

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
406.5, 1324.0
18.943509415097488, 23.19613397767039

Nod1:PGN

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p22

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
315.5, 1234.0
20.699050158306957, 25.345775704049334

Nod2:PGN

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
841.5, 1132.0
20.413264455924015, 24.99583402766206

DDX58:dsRNA

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p25

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
865.5, 1188.0
20.413264455924015, 24.99583402766206

IFIH1:dsRNA

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p39

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
734.5, 1282.0
19.862543585979086, 27.715177096715

DDX58:dsRNA:MAVS

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p51 p63

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1020.5, 923.0
22.435852372583476, 34.51669595782074

GR

--

e36

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p26

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1083.0, 871.5
26.794123566109867, 16.523042865767753

Ligand

--

e37

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p26

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1025.5, 988.0
20.369875027406266, 39.425564569173424

GR:Ligand

--

e38

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p26

p27

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
587.0, 1007.0
33.11418685121107, 17.66089965397924

Scyb9

--

e39

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
193.5191104386571, 182.91447071308468
820.2356464675457, 1242.388529976799

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
547.0, 941.0
41.21107266435987, 21.979238754325266

IP10

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28 p29

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
913.5, 481.0
21.472380253257484, 29.96146081849881

dsRNA:TLR3:TRIF

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31 p32 p33 p34 p46

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
902.0, 563.0
20.382352941176464, 33.9705882352941

dsRNA:TLR3:TRIF:TBK1

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p36 p38

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
866.0, 431.0
20.382352941176464, 33.9705882352941

dsRNA:TLR3:TRIF:IKK-i

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p35 p37

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
818.0, 487.0
20.382352941176464, 33.9705882352941

dsRNA:TLR3:TRIF:IKK-beta

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p75 p76

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
822.0, 364.0
19.499999999999993, 32.499999999999986

dsRNA:TLR3:TRIF:TRAF6

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
360.0, 656.0
24.0, 24.0

IRF-3{p}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p36 p49 p50 p74 p76

p70 p78

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
256.0, 532.0
24.0, 24.0

IRF-7{p}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37 p38 p47 p48 p73 p75

p79

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
898.5, 1298.0
19.862543585979086, 27.715177096715

IFIH1:dsRNA:MAVS

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p52 p64

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
241.5, 150.0
20.777940906588363, 28.992475683611673

LPS:TLR4:TRAM

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
455.5, 147.0
17.9026529269897, 34.65029598772198

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p29 p40 p53

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
400.0405298950789, 835.8300522512169
327.773156270336, 297.25424041648756

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
435.44247228554343, 842.8745456093944
191.65879156217048, 288.0985656603327

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
404.3131781146177, 839.7975113122171
319.2278598312584, 289.3193222944867

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
404.92355643169475, 840.4078896292942
318.00710319710464, 288.0985656603327

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
400.0405298950789, 835.8300522512169
327.773156270336, 297.25424041648756

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
400.0405298950789, 835.8300522512169
327.773156270336, 297.25424041648756

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
404.92355643169475, 840.4078896292942
318.00710319710464, 288.0985656603327

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
639.3088301892533, 957.9057156666123
20.477465852828164, 18.53749540361289

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
585.5955382864796, 1043.3586800573892
57.985940122312684, 52.49253526862

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
400.0405298950789, 835.8300522512169
327.773156270336, 297.25424041648756

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
743.1927256177347, 260.0
224.7936586198395, 375.29110803481643

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
477.2948185753894, 967.9273804602951
10.380094247018796, 4.997823155972016

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
476.94819784677776, 953.0226891299964
35.52862468268811, 63.9515244288386

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
491.85288917707635, 994.6171765633875
5.545931657785457, 5.545931657785458

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
170.0, 275.0
20.294117647058822, 33.82352941176471

LPS:TLR4:TRAM:TRIF

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42 p43 p44 p45

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
170.0, 339.0
20.294117647058822, 33.82352941176471

LPS:TLR4:TRAM:TRIF:IKK-i

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p47 p50

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
174.0, 415.0
20.294117647058822, 33.82352941176471

LPS:TLR4:TRAM:TRIF:TBK1

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p48 p49

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
170.0, 487.0
20.294117647058822, 33.82352941176471

LPS:TLR4:TRAM:TRIF:IKK-beta

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p73 p74

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
568.0, 306.5
24.319999999999993, 18.24

RIP1

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45 p46 p51 p52

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
170.0, 191.0
20.294117647058822, 33.82352941176471

LPS:TLR4:TRAM:TRIF:RIP1

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
878.0, 340.0
19.499999999999993, 32.499999999999986

dsRNA:TLR3:TRIF:RIP1

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p69

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
154.0, 137.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
516.0, 1230.0
16.41176470588235, 27.352941176470587

DDX58:dsRNA:MAVS:RIP1:FADD

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p61

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
620.0, 1351.0
16.147058823529413, 26.911764705882348

IFIH1:dsRNA:MAVS:RIP1:FADD

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p62

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
558.5, 154.0
19.578454762341718, 27.318774086988444

LPS:TLR4:TIRAP

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p53

p54

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
710.0, 152.0
19.147058823529413, 31.911764705882362

LPS:TLR4:TIRAP:MyD88

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p55

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
858.0, 140.0
19.147058823529413, 31.911764705882362

LPS:TLR4:TIRAP:MyD88:IRAK-4

--

e74

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55 p60

p56

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1030.0, 148.0
19.147058823529413, 31.911764705882362

LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

p57

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1026.0, 272.0
19.147058823529413, 31.911764705882362

LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p58

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1034.0, 704.0
19.147058823529413, 31.911764705882362

LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p}

--

e77

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p58

p59

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1030.0, 784.0
19.147058823529413, 31.911764705882362

LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p}:TRAF6

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p59

p60

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
559.0, 1164.0
18.970588235294116, 31.617647058823525

DDX58:dsRNA:MAVs:TRAF6

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p67

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
157.0, 158.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
754.0, 1055.0
17.647058823529413, 29.411764705882344

IFIH1:dsRNA:MAVS:TRAF6

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
455.0, 717.0
17.647058823529413, 29.411764705882344

IFIH1:dsRNA:MAVS:TRAF6:TAK1

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p66

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
323.0, 752.0
18.970588235294116, 31.617647058823525

DDX58:dsRNA:MAVs:TRAF6:TAK1

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p68

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
164.5, 939.0
22.45869947275923, 34.55184534270651

TNF-alphaR

--

e83

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p71

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
164.5, 870.0
22.3409340057005, 43.240517430388074

TNF-alpha:TNF-alphaR

--

e84

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p71

p72

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
499.0, 987.0
34.463667820069205, 18.380622837370243

cytokines

--

e85

cso30:c:mRNA

cso30:i:CC_NuclearChromosome

--

p77 p78 p79 p80

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
165.0, 179.0
877.6580496317298, 1263.4147641295933

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
406.0, 98.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID:16753195,9851930,11607032 For example, lipopolysaccharide (LPS), a common structure of the cell wall of Gram-negative bacteria, is recognized by TLR4 ; double-stranded RNA (dsRNA), which has long been considered a viral PAMP, triggers TLR3 signaling PMID: 16753195,9851930 LPS has long been identified as ligand for TLR4 via analysis of mice with a point mutation in the gene encoding TLR4

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802.0, 674.0
19.0, 19.0

p10

p10

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e20

e21 e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 16753195,15229469 The IRAK1?TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1

Go back
642.0, 702.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016588 MO000016574 MO000022125

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m1583*m1573*m6433*0.1

nodelay

--

true

0

false

PMID: 16753195,15229469 The IRAK1?TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1

Go back
770.0, 734.0
19.0, 19.0

p11

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m21*m22*0.1

nodelay

--

true

0

false

PMID: 16753195,15229469 The IRAK1?TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1

Go back
650.0, 738.0
19.0, 19.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16753195,15229469 The IRAK1?TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1

Go back
478.0, 802.0
19.0, 19.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000000248

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m24*m207*0.1

nodelay

--

true

0

false

PMID: 16753195 The activated TAK1 subsequently activates the I¦ÊB kinases (IKKs), which phosphorylates I¦ÊB and leads to activation of NF-¦ÊB.

Go back
698.0, 830.0
19.0, 19.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000000023

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m24*m29*0.1

nodelay

--

true

0

false

PMID: 16753195,10094049,16186825,15229469 Activation of TAK1 also results in the activation of MAPKs, including c-Jun N-terminal kinase (JNK), leading to activation of AP-1

Go back
298.0, 854.0
19.0, 19.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e25 MO000000215

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m25*m186*0.1

nodelay

--

true

0

false

PMID: 16753195 The activated TAK1 subsequently activates the I¦ÊB kinases (IKKs), which phosphorylates I¦ÊB and leads to activation of NF-¦ÊB.

Go back
218.0, 982.0
19.0, 19.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m26*m27*0.1

nodelay

--

true

0

false

PMID: 16753195 The activated TAK1 subsequently activates the I¦ÊB kinases (IKKs), which phosphorylates I¦ÊB and leads to activation of NF-¦ÊB.

Go back
850.0, 950.0
19.0, 19.0

p15

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000000276

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m30*m219*0.1

nodelay

--

true

0

false

PMID: 16753195,10094049,16186825,15229469 Activation of TAK1 also results in the activation of MAPKs, including c-Jun N-terminal kinase (JNK), leading to activation of AP-1

Go back
322.0, 1326.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042032 MO000020434

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m155701*m4923*0.1

nodelay

--

true

0

false

PMID: 16753195,11058605,11385577,12527755,12766759,12514169 There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-¦ÊB, which is TLR independent

Go back
994.0, 394.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID:16753195,9851930,11607032 For example, lipopolysaccharide (LPS), a common structure of the cell wall of Gram-negative bacteria, is recognized by TLR4 ; double-stranded RNA (dsRNA), which has long been considered a viral PAMP, triggers TLR3 signaling

Go back
266.0, 1286.0
19.0, 19.0

p19

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020461 MO000042032

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m4947*m155701*0.1

nodelay

--

true

0

false

PMID: 16753195,11058605,11385577,12527755,12766759,12514169 There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-¦ÊB, which is TLR independent

Go back
238.0, 1166.0
19.0, 19.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m33*m27*0.1

nodelay

--

true

0

false

PMID: 16753195,11058605,11385577,12527755,12766759,12514169 There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-¦ÊB, which is TLR independent

Go back
342.0, 1166.0
19.0, 19.0

p21

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m32*m27*0.1

nodelay

--

true

0

false

PMID: 16753195,11058605,11385577,12527755,12766759,12514169 There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-¦ÊB, which is TLR independent

Go back
829.0, 1061.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 MO000022224

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c232 : 1
stoichiometry:c67 : 1

m41844*m119368*0.1

nodelay

--

true

0

false

PMID: 16753195 Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif

Go back
937.0, 1157.0
21.0, 21.0

p23

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 MO000022224

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c233 : 1
stoichiometry:c70 : 1

m76904*m119368*0.1

nodelay

--

true

0

false

PMID: 16753195 Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif

Go back
770.0, 1158.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 MO000094908

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m35*m68199*0.1

nodelay

--

true

0

false

PMID: 16753195 Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif

Go back
1086.0, 930.0
20.0, 20.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e36 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 16753195,16143103 More recently, it was shown that the glucocorticoid receptor (GR) can selectively transrepress the transcription of a subset of genes (such as Scyb9), of which promoters utilize IRF3 as an essential coactivator of NF-¦ÊB binding to the ¦ÊB sites upon LPS stimulation

Go back
662.0, 1006.0
19.0, 19.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 16753195,16143103 More recently, it was shown that the glucocorticoid receptor (GR) can selectively transrepress the transcription of a subset of genes (such as Scyb9), of which promoters utilize IRF3 as an essential coactivator of NF-¦ÊB binding to the ¦ÊB sites upon LPS stimulation

Go back
558.0, 866.0
19.0, 19.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041446

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 16753195,16143103 For example, both dsRNA and LPS can activate transcription of the IP10 gene

Go back
518.0, 866.0
19.0, 19.0

p28

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 16753195,16143103 For example, both dsRNA and LPS can activate transcription of the IP10 gene

Go back
890.0, 218.0
20.0, 20.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m19828*m13*0.1

nodelay

--

true

0

false

PMID: 16753195,15229469,15207506 Natural or synthetic oligodeoxynucleotides (OND) containing an unmethylated CpG motif (CpG) can activate TLR9, which exclusively couples to the MyD88-dependent pathway

Go back
973.0, 465.0
21.0, 21.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041446

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c83 : 1
stoichiometry:c85 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 16753195,15229469,15733829 TLR3 signals through myeloid differentiation primary response protein-88 (MyD88)-independent and Toll/interleukin receptor (TIR) domain-containing adaptor-inducing IFN-¦Â (TRIF, also known as TICAM-1)-dependent pathways

Go back
926.0, 654.0
19.0, 19.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c86 : 1
stoichiometry:c88 : 1

m3902*m43*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
518.0, 498.0
19.0, 19.0

p31

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000016608

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m43*m1599*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
461.0, 641.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000000211

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m43*m182*0.1

nodelay

--

true

0

false

PMID: 16753195,14739303,16153868 Besides IKK¦Å and TBK1, TRAF6, IKK¦Â and receptor?interactor protein-1 (RIP1) also interact with TRIF

Go back
497.0, 521.0
21.0, 21.0

p33

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e41

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m183*m43*0.1

nodelay

--

true

0

false

PMID: 16753195,14739303,16153868 Besides IKK¦Å and TBK1, TRAF6, IKK¦Â and receptor?interactor protein-1 (RIP1) also interact with TRIF

Go back
338.0, 494.0
19.0, 19.0

p35

p35

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 MO000007694

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m45*m977*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
398.0, 574.0
19.0, 19.0

p35

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e42 MO000007694

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m44*m977*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
346.0, 458.0
19.0, 19.0

p35

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m45*m980*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
382.0, 530.0
19.0, 19.0

p35

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e42 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m44*m980*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
890.0, 1246.0
19.0, 19.0

p25

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e34

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m68199*m36*0.1

nodelay

--

true

0

false

PMID: 16753195 Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif

Go back
677.0, 273.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000019348

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m332813*0.1

nodelay

--

true

0

false

PMID: 16753195 Upon stimulation of TLRs, MyD88 is recruited to the TIR domain of TLRs.

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334.0, 222.0
19.0, 19.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 e5

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c113 : 1
stoichiometry:c115 : 1

m19005*m5*0.1

nodelay

--

true

0

false

PMID: 16753195,12721283,14519765,14993454,15229469 In addition, two other adaptors, TIR-containing adaptor protein (TIRAP, also known as Mal) and TIR-containing protein (TIRP, also known as TRAM and TICAM-2), participate in those two pathways, respectively

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279.0, 267.0
17.0, 17.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000041125

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m64*m18998*0.1

nodelay

--

true

0

false

PMID: 16753195 TLR4 makes use of both TRIF and MyD88 adaptors to activate IRF3/7, NF-¦ÊB and AP-1 upon the stimulation of LPS.

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266.0, 322.0
19.0, 19.0

p31

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000016608

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m65*m1599*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

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274.0, 374.0
19.0, 19.0

p31

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000019331

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m65*m3902*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

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287.0, 415.0
17.0, 17.0

p33

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000000211

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m65*m182*0.1

nodelay

--

true

0

false

PMID: 16753195,14739303,16153868 Besides IKK¦Å and TBK1, TRAF6, IKK¦Â and receptor?interactor protein-1 (RIP1) also interact with TRIF

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395.0, 295.0
19.0, 19.0

p33

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m65*m69*0.1

nodelay

--

true

0

false

PMID: 16753195,14739303,16153868 Besides IKK¦Å and TBK1, TRAF6, IKK¦Â and receptor?interactor protein-1 (RIP1) also interact with TRIF

Go back
442.0, 382.0
19.0, 19.0

p33

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 e67

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m43*m69*0.1

nodelay

--

true

0

false

PMID: 16753195,14739303,16153868 Besides IKK¦Å and TBK1, TRAF6, IKK¦Â and receptor?interactor protein-1 (RIP1) also interact with TRIF

Go back
330.0, 378.0
19.0, 19.0

p35

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e64 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m66*m980*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

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366.0, 402.0
19.0, 19.0

p35

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e65 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m67*m980*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
226.0, 594.0
19.0, 19.0

p35

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e65 MO000007694

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m67*m977*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
622.0, 350.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000039077

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m15*m17258*0.1

nodelay

--

true

0

false

PMID: 16753195 MyD88 further recruits IRAK4 to form TLR?MyD88?IRAK4 signal complex.

Go back
270.0, 658.0
19.0, 19.0

p35

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e64 MO000007694

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m66*m977*0.1

nodelay

--

true

0

false

PMID: 16753195 The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-¦ÊB activator (TANK) binding kinase 1 (TBK1) and IKK¦Å (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKK¦Å to phosphorylate and activate IRF3/7.

Go back
609.0, 1241.0
21.0, 21.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e35 e67 MO000016899

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m37*m69*m1814*0.1

nodelay

--

true

0

false

PMID: 16753195,16127453,16153868 For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study

Go back
665.0, 1301.0
21.0, 21.0

p51

p52

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e48 MO000016899 e67

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m63*m1814*m69*0.1

nodelay

--

true

0

false

PMID: 16753195,16127453,16153868 For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study

Go back
490.0, 222.0
19.0, 19.0

p40

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e5

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m6810*m5*0.1

nodelay

--

true

0

false

PMID: 16753195,12721283,14519765,14993454,15229469 In addition, two other adaptors, TIR-containing adaptor protein (TIRAP, also known as Mal) and TIR-containing protein (TIRP, also known as TRAM and TICAM-2), participate in those two pathways, respectively

Go back
673.0, 213.0
21.0, 21.0

p4

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019348 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m332813*m74*0.1

nodelay

--

true

0

false

PMID: 16753195 Upon stimulation of TLRs, MyD88 is recruited to the TIR domain of TLRs.

Go back
726.0, 214.0
19.0, 19.0

p5

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e73 MO000039077

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m75*m17258*0.1

nodelay

--

true

0

false

PMID: 16753195 MyD88 further recruits IRAK4 to form TLR?MyD88?IRAK4 signal complex.

Go back
938.0, 226.0
19.0, 19.0

p6

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e74 MO000000213

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m76*m184*0.1

nodelay

--

true

0

false

pMID: 16753195 Then the signal complex (TLR?MyD88?IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.

Go back
950.0, 278.0
19.0, 19.0

p7

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m77*0.1

nodelay

--

true

0

false

pMID: 16753195 Then the signal complex (TLR?MyD88?IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.

Go back
950.0, 710.0
19.0, 19.0

p8

p58

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 16753195 The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex

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898.0, 750.0
20.0, 20.0

p9

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e77 MO000000212

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m79*m183*0.1

nodelay

--

true

0

false

PMID: 16753195 The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex

Go back
666.0, 398.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000000213

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m16*m184*0.1

nodelay

--

true

0

false

pMID: 16753195 Then the signal complex (TLR?MyD88?IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.

Go back
914.0, 814.0
19.0, 19.0

p10

p60

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e78

e21 e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 16753195,15229469 The IRAK1?TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1

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397.0, 1161.0
21.0, 21.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e70 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m72*m27*0.1

nodelay

--

true

0

false

PMID: 16753195 Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-¦ÊB.

Go back
489.0, 1313.0
21.0, 21.0

p61

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e71 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m73*m27*0.1

nodelay

--

true

0

false

PMID: 16753195 Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-¦ÊB.

Go back
681.0, 1169.0
21.0, 21.0

p51

p63

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e35 MO000000212

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m37*m183*0.1

nodelay

--

true

0

false

PMID: 16753195,16127453,16153868 For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study

Go back
713.0, 1133.0
21.0, 21.0

p51

p64

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e48 MO000000212

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m63*m183*0.1

nodelay

--

true

0

false

PMID: 16753195,16127453,16153868 For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study

Go back
753.0, 961.0
21.0, 21.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e80 MO000016574

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m82*m1573*0.1

nodelay

--

true

0

false

PMID: 16753195 Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-¦ÊB.

Go back
341.0, 897.0
21.0, 21.0

p61

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e81 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m83*m27*0.1

nodelay

--

true

0

false

PMID: 16753195 Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-¦ÊB.

Go back
477.0, 1117.0
21.0, 21.0

p65

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e79 MO000016574

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m81*m1573*0.1

nodelay

--

true

0

false

PMID: 16753195 Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-¦ÊB.

Go back
213.0, 901.0
21.0, 21.0

p61

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e82 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m84*m27*0.1

nodelay

--

true

0

false

PMID: 16753195 Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-¦ÊB.

Go back
409.0, 637.0
21.0, 21.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e69 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m71*m27*0.1

nodelay

--

true

0

false

PMID: 16753195,15064760,16115877 However, there also exist some distinct explanations about the involvement of RIP1 in TRIF-mediated NF-¦ÊB activation. It has been suggested that TRIF interacts with RIP1, and this interaction mediates TLR3-triggered NF-¦ÊB activation

Go back
682.0, 450.0
19.0, 19.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m17*0.1

nodelay

--

true

0

false

pMID: 16753195 Then the signal complex (TLR?MyD88?IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.

Go back
225.0, 1097.0
21.0, 21.0

p70

p70

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e46

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m93309*m48*0.1

nodelay

--

true

0

false

PMID: 16753195 The TRIF-dependent pathway first stimulates activation of IRF3 leading to production of TNF alpha, which in turn triggers TNFR signaling to activate NF-¦ÊB. PMID: 16753195,16166516 By asking why the activation dynamics of NF-¦ÊB show damped oscillatory behavior when cells are stimulated by tumor necrosis factor alpha (TNF alpha) but stable behavior when stimulated by LPS, however, proposed that the activation of NF-¦ÊB by TRIF-dependent pathway is a result of a secondary response to TNF alpha, which is induced by IRF3 (activated by TLR4/TRIF-mediated pathway in the first response to LPS) and signals through TNF alpha receptor (TNFR)/RIP1 pathway to activate NF-¦ÊB

Go back
82.5, 945.0
21.5, 21.5

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000289 e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m230*m85*0.1

nodelay

--

true

0

false

PMID: 16753195 The TRIF-dependent pathway first stimulates activation of IRF3 leading to production of TNF alpha, which in turn triggers TNFR signaling to activate NF-¦ÊB. PMID: 16753195,16166516 By asking why the activation dynamics of NF-¦ÊB show damped oscillatory behavior when cells are stimulated by tumor necrosis factor alpha (TNF alpha) but stable behavior when stimulated by LPS, however, proposed that the activation of NF-¦ÊB by TRIF-dependent pathway is a result of a secondary response to TNF alpha, which is induced by IRF3 (activated by TLR4/TRIF-mediated pathway in the first response to LPS) and signals through TNF alpha receptor (TNFR)/RIP1 pathway to activate NF-¦ÊB

Go back
221.0, 817.0
21.0, 21.0

p72

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e84 MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1
stoichiometry:c211 : 1

m86*m27*0.1

nodelay

--

true

0

false

PMID: 16753195 The TRIF-dependent pathway first stimulates activation of IRF3 leading to production of TNF alpha, which in turn triggers TNFR signaling to activate NF-¦ÊB. PMID: 16753195,16166516 By asking why the activation dynamics of NF-¦ÊB show damped oscillatory behavior when cells are stimulated by tumor necrosis factor alpha (TNF alpha) but stable behavior when stimulated by LPS, however, proposed that the activation of NF-¦ÊB by TRIF-dependent pathway is a result of a secondary response to TNF alpha, which is induced by IRF3 (activated by TLR4/TRIF-mediated pathway in the first response to LPS) and signals through TNF alpha receptor (TNFR)/RIP1 pathway to activate NF-¦ÊB

Go back
322.0, 326.0
19.0, 19.0

p73

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e66 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m68*m980*0.1

nodelay

--

true

0

false

PMID: 16753195 The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKK¦Â, IKK¦Å and/or TBK1 for activation of IRF3/7.

Go back
230.0, 678.0
19.0, 19.0

p73

p74

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e66 MO000007694

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m68*m977*0.1

nodelay

--

true

0

false

PMID: 16753195 The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKK¦Â, IKK¦Å and/or TBK1 for activation of IRF3/7.

Go back
394.0, 346.0
19.0, 19.0

p73

p75

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e44 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1

m46*m980*0.1

nodelay

--

true

0

false

PMID: 16753195 The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKK¦Â, IKK¦Å and/or TBK1 for activation of IRF3/7.

Go back
406.0, 422.0
19.0, 19.0

p73

p76

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e44 MO000007694

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m46*m977*0.1

nodelay

--

true

0

false

PMID: 16753195 The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKK¦Â, IKK¦Å and/or TBK1 for activation of IRF3/7.

Go back
438.0, 934.0
19.0, 19.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e27

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 16753195 Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-¦ÊB (NF-¦ÊB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.

Go back
462.0, 906.0
19.0, 19.0

p77

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 16753195 Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-¦ÊB (NF-¦ÊB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.

Go back
486.0, 874.0
19.0, 19.0

p77

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 16753195 Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-¦ÊB (NF-¦ÊB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.

Go back
686.0, 522.0
19.0, 19.0

p8

p8

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 16753195 The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex

Go back
530.0, 1058.0
19.0, 19.0

p77

p80

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 16753195 Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-¦ÊB (NF-¦ÊB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.

Go back
638.0, 610.0
20.0, 20.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m183*m19*0.1

nodelay

--

true

0

false

PMID: 16753195 The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex

Go back
366.0, 108.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.9913606886246, 280.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 513.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.9997279339559, 580.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 584.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.15135438863337, 593.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.9936331321664, 448.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
264.0, 471.53208287535716

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.05458406215325, 477.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.9770869556875, 541.6050485116091

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
264.0, 492.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.99385560585233, 540.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 233.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.0, 1256.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.0, 1213.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 1265.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
359.97079614211566, 169.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.0, 235.61550242917951

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.442695071149, 176.74253942737354

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.0, 179.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.35487277668346, 282.14735546749966

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.91599903935696, 277.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 296.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 288.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.3174928327581, 339.23331078656753

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.76114000116266, 334.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 301.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.2131802618963, 391.4597731875644

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.2262200348343, 389.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 304.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
310.4, 434.8

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.58241966672387, 430.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 293.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.98637323287613, 306.46673609802525

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.6087503143028, 319.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.33826670071514, 215.18588164079827

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.81192336598497, 395.72448639425716

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.8655984870979, 323.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 357.650120781893

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 358.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
263.0, 403.0253358311251

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.33879957198724, 397.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.0, 413.83266211655615

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
264.0, 422.2039430457753

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.0719701378761, 421.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0, 360.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0, 449.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
252.75334824874898, 587.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.0, 608.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
185.0, 373.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
287.19413413823963, 596.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 668.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.5452483693153, 1258.65880180633

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 325.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.9758226445091, 1245.6214926735981

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 1255.4133125023502

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 362.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.0, 1312.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 1285.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 325.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.4774036933123, 1322.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.0, 225.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.0, 182.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 182.4792800701431

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 224.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 173.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 190.69168903663802

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.949974496936, 397.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 184.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
554.0, 235.62834814469798

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 164.6530903510587

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.0, 165.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 244.69645236228578

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 176.92347595993877

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.3431960354728, 179.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0, 288.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
963.3781009887165, 304.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0, 720.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.0, 411.83231466980436

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.6770283510817, 723.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 608.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.0, 763.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.8351867815206, 802.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.036667986216, 762.2154626212879

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.6705294279822, 179.9718498660104

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.7917619230036, 1182.2275252786044

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
355.0, 990.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.76062313317, 1060.5511459283275

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.6432211278632, 1329.3624501667941

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
685.0, 412.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 990.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.99164807039875, 1061.2516757386547

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.2564755217952, 1197.3072133659794

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 614.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 1180.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.9195205871675, 1158.3813823519704

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0, 614.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 1091.1260949576658

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.0, 989.9992494957534

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 726.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 460.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.2469504755442, 743.9975603804354

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.292110576306, 746.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.0, 926.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.89030346616175, 918.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.68995493908693, 1138.386855697762

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.6611944128808, 726.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.17528920548375, 791.3428562876811

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
236.80845022986853, 780.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
241.04795543439116, 920.7850131036545

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 922.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.0, 122.65685424949238

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 466.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.7839864320407, 362.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
354.0, 665.836821605132

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.7275024265329, 658.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.52252212232844, 1028.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
241.3642751283175, 680.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
129.55200922557256, 1070.6395372050545

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
96.35925533206117, 974.8836809259548

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
112.0, 956.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.0, 905.8827051358348

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.0, 844.0740528189224

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
712.7685735448305, 515.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.9509778128281, 844.2839333778203

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
234.0, 838.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 350.9303872745624

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
258.0, 352.0781733711499

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.33254947722173, 345.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
186.0, 521.0

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.72407995507373, 596.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 671.2111037952442

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.5494126620231, 361.6469545629809

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
264.0, 370.24827974911

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.0, 538.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.6938333458865, 365.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.882868857952, 435.36395695252094

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 447.6876514078999

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.4632633294639, 441.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
287.0, 954.028121803566

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.0, 951.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.0, 680.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.0, 925.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 556.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
498.0, 893.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.0, 605.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.9258326123768, 1026.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.5726594108631, 1012.5750527097637

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
846.9452197011507, 417.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.5994725647622, 417.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.6039626014052, 583.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 620.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.2719439311038, 636.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 693.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.7599071602144, 419.9638270390469

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.0, 678.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 117.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 712.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 723.5685159055888

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 684.9364580533432

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.0, 744.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.0, 687.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 753.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.4404159196479, 754.9394235731943

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.1552790744792, 756.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.9904988089992, 808.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.0, 772.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
943.0, 360.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
391.0, 812.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.20449602968955, 822.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
260.0, 795.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.0, 873.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.06735586479, 929.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
244.9639637807516, 981.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 1001.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 810.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
725.0, 840.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
717.0, 849.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1021.0, 404.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.0, 925.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.0, 908.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 969.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.0, 1344.399257096111

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.8551517954508, 1349.4513482233508

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
341.0, 1336.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.0, 1263.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 1312.8911513906571

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 1262.5633714201285

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
262.95136622435615, 1189.3461425405233

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.4759018794317, 408.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.76886726939586, 990.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 1062.8193133235188

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.94342367860264, 1192.4388343877413

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.0, 990.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.99597775475326, 1061.9305239184002

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 1072.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.0, 1082.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 1186.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.0, 245.90851679165618

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.2926940551123, 1173.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.6177225322558, 1148.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.3902826712724, 1184.8782684705434

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.1297852398085, 1177.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.0, 940.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 888.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.258950015918, 950.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.9989250291644, 1008.0

c77

c77

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
628.0, 1016.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.1129463263483, 440.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
881.0, 116.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 885.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.0, 182.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
533.0, 885.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.0, 440.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
973.0, 493.923938185422

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.6286613210731, 480.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.0, 511.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.0, 664.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.1620511210258, 604.7023071186542

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.9959504205171, 496.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.2033200579111, 233.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 448.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 451.3423947843869

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.5627977925722, 500.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.0, 568.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 511.0769230769231

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.079787787583, 549.7249260681654

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.970675243614, 497.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.0, 388.3856940415271

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.955355837436, 449.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.0, 520.4536640138874

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back