1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16754322.csml convertedTime:2009.07.01.10:55

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Complement-mediated phagocytosis--the role of Syk.
Authors Tohyama Y, Yamamura H.
Affiliation Himeji Dokkyo University, Hyogo, and Hyogo Prefectural Institute of PublicHealth and Environmental Sciences, Kobe, Japan. ytohyama@himeji-du.ac.jp
Abstract Phagocytosis is a central event in the innate immune responses that aretriggered by the association between ligands on the surface of pathogens andreceptors on the membrane of phagocytes. Particularly, complement-mediatedphagocytosis is accomplished by specific recognition of bound complementcomponents by the corresponding complement receptors on the phagocytes. Theprotein-tyrosine kinase, Syk, plays a central role in Fcgamma receptor-mediatedphagocytosis in the adaptive immune system. From recent studies using amacrophage-like differentiated cell line and serum-treated zymosan, it was foundthat Syk also plays an essential role in complement-mediated phagocytosis ininnate immunity. Serum-treated zymosan particles promptly attached to the cellsand were subsequently engulfed via complement receptor3. During this process,Syk became tyrosine-phosphorylated and accumulated around the nascentphagosomes. The transfer of Syk-siRNA or dominant-negative Syk (DN-Syk) intomacrophages resulted in impaired engulfment of pathogen. Collectively, Syk isrequired for the engulfment of pathogen in complement-mediated phagocytosis.
PMID 16754322
Model Abstract

Entity

MO000000044:Vav MO000003165:complement C3 MO000008301:Syk MO000016577:RhoA MO000017380:beta2-integrin MO000034980:C3a e1: e10:Syk:alphaIIbbeta3 e11:C3bi e12:CR1 e13:CR1:C3bi e14:CR3 e15:CR3:C3bi e16:CR4:C3bi e17:CR4 e18:Zymosan e19:C3 convertase e2: e20:cofactor proteins e21:C3bi:Zymosan e22:Syk{pY} e23:RhoA{active} e24:Vav{pY} e3: e4: e5:complement C3{active} e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:C3b e60: e61: e62: e7: e8:Syk:beta2-integrin e9:alphaIIbbeta3

Process

p1 p10 p11 p12 p13 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
513.0, 481.0
22.0, 22.0

Vav

--

MO000000044

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
246.0, 30.0
20.0, 20.0

complement C3

--

MO000003165

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m441

10

false

infinite

0

unit false false false
InterProIPR002890
TRANSPATHMO000003165

--

Go back
750.0, 478.0
20.0, 20.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9 p11 p12 p13

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
654.0, 582.0
20.0, 20.0

RhoA

--

MO000016577

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m1574

10

false

infinite

0

unit false false false
InterProIPR005225
TRANSPATHMO000016577

--

Go back
910.0, 414.0
20.0, 20.0

beta2-integrin

--

MO000017380

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m2214

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017380

--

Go back
574.0, 38.0
20.0, 20.0

C3a

--

MO000034980

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m13505

10

false

infinite

0

unit false false false
InterProIPR002890
TRANSPATHMO000034980

--

Go back
204.5946228742344, 330.0125257821535
743.0055460825985, 1078.8440529119318

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
906.5, 569.0
19.86691515018636, 38.45209383907037

Syk:alphaIIbbeta3

--

e10

cso30:c:Complex

cso30:i:CC_Cell

--

p9

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
581.5, 233.0
13.901992352586033, 22.54377138257194

C3bi

--

e11

cso30:c:Protein

cso30:i:CC_Extracellular

--

p3

p4 p5 p6 p10

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
576.5, 346.0
23.875219683655544, 36.73110720562391

CR1

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
645.5, 339.0
21.831177373383028, 42.25389169041877

CR1:C3bi

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
512.5, 347.0
22.527240773286465, 34.65729349736379

CR3

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
434.5, 341.0
19.547467660600745, 37.83380837535628

CR3:C3bi

--

e15

cso30:c:Complex

cso30:i:CC_Extracellular

--

p5

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
774.5, 342.0
18.942556456917345, 36.663012497259366

CR4:C3bi

--

e16

cso30:c:Complex

cso30:i:CC_Extracellular

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
700.5, 347.0
22.52724077328647, 34.657293497363796

CR4

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
745.0, 102.5
29.64379150734554, 18.28033809619642

Zymosan

--

e18

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7 p10

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
689.0, 170.0
21.970588235294112, 36.61764705882353

C3 convertase

--

e19

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
204.5946228742344, 330.0125257821535
743.0055460825985, 1078.8440529119318

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
697.0, 31.0
14.520112254443406, 33.50795135640786

cofactor proteins

--

e20

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
946.5, 292.0
18.984335944009324, 23.24612564572571

C3bi:Zymosan

--

e21

cso30:c:Complex

cso30:i:CC_Cell

--

p10

p11

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
667.0, 418.0
25.0, 20.000000000000007

Syk{pY}

--

e22

cso30:c:Protein

cso30:i:CC_Extracellular

--

p11

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
738.0, 650.0
20.0, 20.0

RhoA{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR005225
TRANSPATHMO000016577

--

Go back
545.0, 569.0
22.0, 22.0

Vav{pY}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
219.45473379588628, 344.8726367038056
713.2853242392948, 1049.1238310686292

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
246.94593900094253, 370.87783081669625
658.3029138291821, 997.1134428428464

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
414.0, 70.0
20.0, 20.0

complement C3{active}

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
InterProIPR002890
TRANSPATHMO000003165

--

Go back
397.5795791677633, 963.6245855250467
380.9899397267369, 345.51601610227374

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
438.7293305721407, 971.8128128053914
222.77624036163016, 334.87383901493473

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
402.54592847518825, 968.2361955962268
371.05724111188715, 336.2927959599131

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
403.25540694767733, 968.9456740687158
369.63828416690865, 334.87383901493473

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
397.5795791677633, 963.6245855250467
380.9899397267369, 345.51601610227374

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
397.5795791677633, 963.6245855250467
380.9899397267369, 345.51601610227374

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
403.25540694767733, 968.9456740687158
369.63828416690865, 334.87383901493473

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
675.6951403835565, 1105.5202800228994
23.80215808335059, 21.547216791243716

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
613.261034804501, 1204.8472661713977
67.40045488648042, 61.015148634077136

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
397.5795791677633, 963.6245855250467
380.9899397267369, 345.51601610227374

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
576.0, 103.5
23.039999999999996, 17.279999999999994

C3b

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

p2

p3 p7

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
487.3767642785173, 1117.1690480585526
12.065391585233504, 5.809262615112436

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
486.97386670141117, 1099.8444522429863
41.297001653384726, 74.33460297609255

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
504.2984625169779, 1148.1921614957294
6.446361233699074, 6.446361233699078

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
210.77430233271934, 356.22891613625825
722.6968642197772, 1024.0427891527474

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
911.5, 475.0
17.29774172330629, 33.47950010962509

Syk:beta2-integrin

--

e8

cso30:c:Complex

cso30:i:CC_Cell

--

p8

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
908.5, 643.0
22.48154657293497, 34.58699472759225

alphaIIbbeta3

--

e9

cso30:c:Protein

cso30:i:CC_Cell

--

--

p9

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
323.0, 31.0
17.0, 17.0

p1

p1

cso30:i:ME_Hydrolysis

cso30:i:CC_Extracellular

--

MO000003165

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m441*0.1

nodelay

--

true

0

false

PMID: 16754322 This pathway does not depend on a pathogen-binding protein for its initiation but is initiated through the spontaneous hydrolysis of C3, as shown in Fig. 1.

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803.0, 235.0
17.0, 17.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 e11

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c27 : 1
stoichiometry:c29 : 1

m18*m11*0.1

nodelay

--

true

0

false

PMID: 16754322 Zymosan particles were pretreated with the normal serum in order that C3bi in the serum bind to zymosan (C3bi-zymosan).

Go back
853.0, 293.0
21.0, 21.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000008301 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c32 : 1
stoichiometry:c31 : 1

m1066*m21*0.1

nodelay

--

true

0

false

PMID: 16754322 Next we analyzed the dynamics of endogenous Syk in the cells pretreated with C3bi-zymosan and found that Syk was tyrosine-phosphorylated and obviously accumulated in the region of forming phagosomes.

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738.0, 562.0
19.0, 19.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000016577 MO000008301

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m1574*m1066*0.1

nodelay

--

true

0

false

PMID: 16754322 Treatment of the parental HL60 cells with C3bi-zymosan led to the prompt activation of RhoA, but DN-Syk/HL or SyksiRNA/ HL cells revealed suppressed RhoA activation.

Go back
585.0, 461.0
21.0, 21.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000000044 MO000008301

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c33 : 1
stoichiometry:c38 : 1

m41*m1066*0.1

nodelay

--

true

0

false

PMID: 16754322 Next we examined the tyrosine phosphorylation of Vav, a guanine nucleotide exchange factor of RhoA and found that Vav was tyrosine-phosphorylated prior to RhoA activation in the parental HL60 cells but the phosphorylation was reduced in DN-Syk/HL or Syk-siRNA/HL cells just like the pattern of RhoA activation.

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501.0, 69.0
21.0, 21.0

p2

p2

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

e5

MO000034980 e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 16754322 Cleavage of C3 to C3b and finally to C3bi is amplified, and zymosan is surrounded by C3bi and incorporated effectively by phagocytes which express CR3.

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577.0, 165.0
21.0, 21.0

p2

p3

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 16754322 Cleavage of C3 to C3b and finally to C3bi is amplified, and zymosan is surrounded by C3bi and incorporated effectively by phagocytes which express CR3.

Go back
579.0, 287.0
17.0, 17.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m11*m12*0.1

nodelay

--

true

0

false

PMID: 16754322 The final product C3bi binds to three other complement receptors CR1, CR3 (CD11b/CD18, integrin alphaMbeta2) and CR4 (CD11c/CD18, integrin alphaXbeta2).

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499.0, 279.0
17.0, 17.0

p4

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m11*m14*0.1

nodelay

--

true

0

false

PMID: 16754322 The final product C3bi binds to three other complement receptors CR1, CR3 (CD11b/CD18, integrin alphaMbeta2) and CR4 (CD11c/CD18, integrin alphaXbeta2).

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703.0, 279.0
17.0, 17.0

p4

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 e17

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m11*m17*0.1

nodelay

--

true

0

false

PMID: 16754322 The final product C3bi binds to three other complement receptors CR1, CR3 (CD11b/CD18, integrin alphaMbeta2) and CR4 (CD11c/CD18, integrin alphaXbeta2).

Go back
662.0, 102.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e18 e20

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1

m6*m18*m20*0.1

nodelay

--

true

0

false

PMID: 16754322 As previously described, C3b is spontaneously produced and destroyed, and when non-self microbes such as zymosan are exposed to the serum at 37 degreeC, C3b binds to zymosan covalently and becomes C3 convertase by the action of cofactor proteins.

Go back
998.0, 414.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000017380 MO000008301

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m2214*m1066*0.1

nodelay

--

true

0

false

PMID: 16754322 In addition to these roles in immunoreceptor signaling, Syk is also activated on ligation with cell surface integrins, such as integrin alphaIIbbeta3 in platelets and beta2 integrin in neutrophils or monocytes.

Go back
1010.0, 526.0
19.0, 19.0

p8

p9

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e9 MO000008301

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m9*m1066*0.1

nodelay

--

true

0

false

PMID: 16754322 In addition to these roles in immunoreceptor signaling, Syk is also activated on ligation with cell surface integrins, such as integrin alphaIIbbeta3 in platelets and beta2 integrin in neutrophils or monocytes.

Go back
266.0, 40.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 303.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.0231645833151, 248.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.5393156857681, 303.85050999741725

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.30789736262074, 296.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 247.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.0, 304.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 296.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 112.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.0, 112.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.0, 121.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 44.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
680.5777087639997, 62.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
930.0, 424.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 428.9722729321518

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.3444084952466, 432.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.0, 551.2107925315546

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 490.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.1554175279994, 541.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 244.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 121.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 247.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
434.0, 80.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.0, 320.9771443289089

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.624581907201, 311.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.0, 304.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.9624572941336, 473.7741277924852

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
674.0, 575.9402850002907

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.0, 581.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.2350150421889, 498.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.0, 477.1570394041598

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.7616431473434, 482.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.0, 55.236048118221625

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.0, 84.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 121.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 186.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 256.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 312.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back