1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16762830.csml convertedTime:2009.07.01.10:55

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors and RNA helicases: two parallel ways to trigger antiviralresponses.
Authors Meylan E, Tschopp J.
Affiliation Department of Biochemistry, University of Lausanne, BIL Biomedical ResearchCenter, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
Abstract The early detection by the host of invading microorganisms, including viruses,depends on a limited number of specific receptors that recognizepathogen-associated molecular patterns (PAMPs). A few of these PAMPs, includingssRNA and dsRNA, are recognized by Toll-like receptors (TLR)-7/8 and TLR3,respectively. Activation of an antiviral TLR-dependent signaling cascade leadsto the activation of the key transcription factors IRF and NF-kappaB, whichpromote antiviral responses through induction of specific genes. Recently, asecond system has been described, which relies on the cytoplasmic recognition ofdsRNA by RNA helicases such as RIG-I. In this review, we discuss the mechanisticaspects of these important arms of the host innate response to dsRNA and a fewviral strategies utilized to counteract them.
PMID 16762830
Model Abstract

Entity

MO000000058:NF-kappaB MO000000065:RIP1k63{ub} MO000000204:TNF MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK MO000007694:IRF-3 MO000007702:IRF-7 MO000008179:PKR MO000016573:MyD88 MO000016591:A20 MO000016608:IKK-i MO000016962:TRAF1 MO000016963:TRAF3 MO000019241:RIP3 MO000019331:TBK1 MO000019398:TLR3 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10:DDX58:dsRNA:MAVS:TBK1:IKK-i e11: e12:dsRNA:TLR3 e13:ssRNA e14:TLR7:ssRNA e15:TLR8:ssRNA e16:CpG motif e17:TLR9:CpG motif e18:dsRNA:TLR3:TRIF e19:dsRNA:TLR3:TRIF:TRAF6 e2: e20:dsRNA:TLR3:TRIF:TRAF6:RIP1 e21:NF-kappaB{active} e22:dsRNA:TLR3:TRIF:TRAF6:RIP3 e23:TLR7:ssRNA:MyD88 e24:dsRNA:TLR3:TRIF:TRAF3 e25:TLR7:ssRNA:MYD88:IRAK1:IRAK-4 e26:dsRNA:TLR3:TRIF:TRAF3:TBK1:IKK-i e27:IRF-3{active} e28:TLR7:ssRNA:MYD88:IRAK1:IRAK-4:TRAF3:TRAF6 e29:DDx58:dsRNA e3: e30:DDX58:dsRNA:MAVS e31:A46R e32:TLR7:ssRNA:MyD88:A46R e33:A46R:TIRAP e34:A46R:TRAM e35:DDX58:dsRNA:MAVS:IKK-alpha:IKK-beta e36:TLR7:ssRNA:MYD88:IRAK1:IRAK-4:TRAF3:TRAF6:TBK1:IKK-i e37:TLR7:ssRNA:MYD88:IRAK1:IRAK-4:TRAF3:TRAF6:IKK-alpha:IKK-beta e38:dsRNA:TLR3:TRIF:TRAF6:RIP1:IKK-alpha:IKK-beta e39:IFIH1:dsRNA e4: e40:IFIH1:dsRNA:MAVS e41:IFIH1:dsRNA:MAVS:TBK1:IKK-i e42:IFIH1:dsRNA:MAVS:IKK-alpha:IKK-beta e43:Lgp2 e44:Lgp2:dsRNA e45:protein remnants e46:SIKE e47:SIKE:IRF-3 e48:IRF-7{active} e49:SIKE:IRF-7 e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:SIKE:TBK1 e64:SIKE:IKK-i e65:V-proteins e66:IFIH1:V-proteins e67:Type I IFN e68:Type I IFN e69:PKR:dsRNA e7: e70:eIF2{alpha) e71:eIF2{alpha){active} e72:2'-5'oligoadenylate synthetase e73:2'-5' oligoadenylate synthetase:dsRNA e74:endoribonuclease RNase L e75:endoribonuclease RNase L{active} e76:RIP1 e77:RIP1-K48{ub} e78:NS3-4A e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p6 p7 p8 p9
Model Detail
629.0, 725.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p17 p26 p35 p38

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
519.0, 403.0
18.0, 18.0

RIP1k63{ub}

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p38 p55

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1275.0, 859.0
18.0, 18.0

TNF

--

MO000000204

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m175

10

false

infinite

0

unit false false false
TRANSPATHMO000000204

--

Go back
422.0, 346.0
20.0, 20.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p28 p29 p34

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
335.0, 431.0
18.0, 18.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p28 p29 p34

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
493.0, 445.0
21.0, 21.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p15

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1046.0, 378.0
20.0, 20.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
648.0, 800.0
23.5, 23.5

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p16 p24 p33 p40

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
514.0, 1098.0
20.0, 20.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p45 p48 p49 p50

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
545.0, 221.0
22.0, 22.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
982.0, 202.0
20.0, 20.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1006.0, 950.0
20.0, 20.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p26 p39 p55

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
335.0, 635.0
18.0, 18.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p23 p27 p32 p43

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1016.0, 1108.0
16.0, 16.0

TRAF1

--

MO000016962

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p13

true true true true

csml-variable:Double

m1871

10

false

infinite

0

unit false false false
InterProIPR002083
TRANSPATHMO000016962

--

Go back
486.0, 342.0
20.5, 20.5

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p15

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
562.0, 518.0
20.0, 20.0

RIP3

--

MO000019241

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m3825

10

false

infinite

0

unit false false false
TRANSPATHMO000019241

--

Go back
254.0, 582.0
20.0, 20.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p23 p27 p32 p42

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
787.0, 319.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
764.0, 88.0
24.0, 24.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p18 p30 p36 p51 p53

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
287.0, 759.0
18.0, 18.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1038.0, 434.0
20.0, 20.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
595.0, 395.0
17.0, 17.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p39 p57

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
274.0, 990.0
19.0, 19.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
923.0, 455.0
18.0, 18.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
950.0, 530.0
20.5, 20.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
821.0, 309.0
21.0, 21.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
614.0, 310.0
20.0, 20.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
289.0, 361.0
21.0, 21.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p31 p58

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
334.0, 1114.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p44

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
178.70771930246588, 121.30810059669538
1068.5230078812972, 1551.495407443641

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
439.0, 541.0
17.82352941176471, 29.70588235294118

DDX58:dsRNA:MAVS:TBK1:IKK-i

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p23

p24 p49

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
727.0, 311.0
297.0665048451631, 495.9500123262467

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
746.5, 329.0
19.499890374917776, 37.741723306292485

dsRNA:TLR3

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
858.0, 79.5
60.0, 33.0

ssRNA

--

e13

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p2 p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
862.5, 330.0
18.752247314185485, 36.29467222100416

TLR7:ssRNA

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p10

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
910.5, 350.0
18.752247314185485, 36.29467222100416

TLR8:ssRNA

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1274.0, 477.5
60.0, 13.0

CpG motif

--

e16

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
930.5, 562.0
18.670686253014683, 36.13681210260908

TLR9:CpG motif

--

e17

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p4

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
742.5, 378.0
19.65736832446321, 27.42888603413471

dsRNA:TLR3:TRIF

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6 p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
747.0, 429.0
18.08823529411765, 30.147058823529417

dsRNA:TLR3:TRIF:TRAF6

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7 p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
178.70771930246588, 121.30810059669538
1068.5230078812972, 1551.495407443641

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
747.0, 477.0
18.08823529411765, 30.147058823529417

dsRNA:TLR3:TRIF:TRAF6:RIP1

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p29

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
453.0, 813.0
22.0, 22.0

NF-kappaB{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p17 p26 p35 p38

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
767.0, 529.0
18.08823529411765, 30.147058823529417

dsRNA:TLR3:TRIF:TRAF6:RIP3

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p7

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
946.5, 354.0
19.886217654615525, 27.748210680858875

TLR7:ssRNA:MyD88

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p14 p20

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
779.0, 701.0
17.647058823529417, 29.41176470588237

dsRNA:TLR3:TRIF:TRAF3

--

e24

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

p12

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
975.0, 481.0
18.17647058823529, 30.29411764705882

TLR7:ssRNA:MYD88:IRAK1:IRAK-4

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
799.0, 769.0
17.647058823529417, 29.41176470588237

dsRNA:TLR3:TRIF:TRAF3:TBK1:IKK-i

--

e26

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p12

p13 p45

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
640.0, 892.0
23.5, 23.5

IRF-3{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13 p16 p24 p33

p47

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
943.0, 629.0
18.17647058823529, 30.29411764705882

TLR7:ssRNA:MYD88:IRAK1:IRAK-4:TRAF3:TRAF6

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p28

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
330.5, 313.0
18.004499250124972, 22.04632561239794

DDx58:dsRNA

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
200.0781794600919, 142.67856075432144
1025.7820875660461, 1508.7544871283908

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
290.5, 450.0
19.854652229766934, 27.70416590200038

DDX58:dsRNA:MAVS

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p23 p25

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
451.0, 852.0
10.774555659494856, 24.8643592142189

A46R

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13 p20 p21 p22

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
883.0, 749.0
17.470588235294116, 29.117647058823536

TLR7:ssRNA:MyD88:A46R

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
309.5, 695.0
20.690884852524576, 25.335777370438258

A46R:TIRAP

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
410.5, 977.0
18.772037993667723, 22.986168971838026

A46R:TRAM

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
271.0, 505.0
17.82352941176471, 29.70588235294118

DDX58:dsRNA:MAVS:IKK-alpha:IKK-beta

--

e35

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p25

p26

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
887.0, 677.0
18.17647058823529, 30.29411764705882

TLR7:ssRNA:MYD88:IRAK1:IRAK-4:TRAF3:TRAF6:TBK1:IKK-i

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p16 p48

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
859.0, 581.0
18.17647058823529, 30.29411764705882

TLR7:ssRNA:MYD88:IRAK1:IRAK-4:TRAF3:TRAF6:IKK-alpha:IKK-beta

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p17

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
815.0, 593.0
18.08823529411765, 30.147058823529417

dsRNA:TLR3:TRIF:TRAF6:RIP1:IKK-alpha:IKK-beta

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p8

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
463.5, 1142.0
17.032827862022998, 20.85652391268122

IFIH1:dsRNA

--

e39

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p30

p31

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
239.6135307517, 180.07686603016634
946.7113849828299, 1433.957876576699

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
609.5, 1049.0
20.99889888052854, 29.30078913562122

IFIH1:dsRNA:MAVS

--

e40

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p31

p32 p34

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
834.0, 1079.0
19.941176470588243, 33.23529411764707

IFIH1:dsRNA:MAVS:TBK1:IKK-i

--

e41

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p32

p33 p50

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
414.0, 891.0
19.941176470588243, 33.23529411764707

IFIH1:dsRNA:MAVS:IKK-alpha:IKK-beta

--

e42

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p34

p35

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
284.5, 255.0
15.540148923324614, 25.20024149728315

Lgp2

--

e43

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p36

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
386.5, 276.0
19.80903182802866, 24.25595734044326

Lgp2:dsRNA

--

e44

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p36

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
995.0, 1027.0
18.265364732912126, 17.656519241815054

protein remnants

--

e45

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p37 p39 p57 p58

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
869.0, 1179.5
21.439999999999998, 16.08

SIKE

--

e46

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p40 p41 p42 p43

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
745.5, 1267.0
20.960339943342774, 25.6657223796034

SIKE:IRF-3

--

e47

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p40

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
646.0, 1230.0
20.0, 20.0

IRF-7{active}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45 p48 p49 p50

p46

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
677.5, 1135.0
20.960339943342774, 25.6657223796034

SIKE:IRF-7

--

e49

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p41

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
727.0, 311.0
297.0665048451631, 495.9500123262467

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
341.9987185442763, 1190.3262379663943
259.5827050458538, 235.4129932166309

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
370.0355842661746, 1195.9051836689678
151.78579028751955, 228.16207966786394

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
345.3824782003674, 1193.4683005041932
252.81518573367126, 229.12886814103288

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
345.86587243695215, 1193.9516947407778
251.84839726050237, 228.16207966786394

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
341.9987185442763, 1190.3262379663943
259.5827050458538, 235.4129932166309

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
341.9987185442763, 1190.3262379663943
259.5827050458538, 235.4129932166309

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
345.86587243695215, 1193.9516947407778
251.84839726050237, 228.16207966786394

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
531.4892592853832, 1287.0050852832862
16.217301133034546, 14.680925236220771

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
488.9505664659508, 1354.6802784051092
45.92245247552343, 41.57190434626338

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
341.9987185442763, 1190.3262379663943
259.5827050458538, 235.4129932166309

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
727.0, 311.0
297.0665048451631, 495.9500123262467

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
403.1809015522359, 1294.9418269182877
8.220602852082603, 3.958068039891628

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
402.9063923539177, 1283.1379313906095
28.137192827604718, 50.64694708968848

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
414.71028788159606, 1316.079035188782
4.392147173089512, 4.3921471730895165

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
941.5, 1135.0
20.960339943342774, 25.6657223796034

SIKE:TBK1

--

e63

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p42

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
893.5, 1003.0
20.960339943342774, 25.6657223796034

SIKE:IKK-i

--

e64

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p43

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
758.0, 1307.5
27.486818980667834, 17.86643233743409

V-proteins

--

e65

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p44

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
678.5, 1384.0
19.12314614230961, 23.41609731711381

IFIH1:V-proteins

--

e66

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p44

p46 p47

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
435.0, 1311.0
34.51557093425605, 18.408304498269896

Type I IFN

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p46 p47

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
130.0, 1298.0
12.087932647333954, 27.895229186155284

Type I IFN

--

e68

cso30:c:Protein

cso30:i:CC_Extracellular

--

p46 p47

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
678.5, 264.0
19.1803032827862, 23.486085652391267

PKR:dsRNA

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p51

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
203.5740571864402, 130.0300092206332
960.3706053415896, 1360.8203411482311

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
422.0, 228.5
20.16, 15.120000000000001

eIF2{alpha)

--

e70

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p52

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
522.0, 296.5
20.16, 15.120000000000001

eIF2{alpha){active}

--

e71

cso30:c:Protein

cso30:i:CC_Extracellular

--

p52

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1089.5, 265.0
13.753069027973435, 22.30227409941638

2'-5'oligoadenylate synthetase

--

e72

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p53

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1090.5, 324.0
19.400766538910183, 23.75604065989002

2'-5' oligoadenylate synthetase:dsRNA

--

e73

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p53

p54

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1130.0, 802.0
12.063610851262862, 27.83910196445275

endoribonuclease RNase L

--

e74

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p54

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1082.0, 910.0
12.063610851262862, 27.83910196445275

endoribonuclease RNase L{active}

--

e75

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p54

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1079.0, 1015.0
18.0, 18.0

RIP1

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p56

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1087.0, 1239.0
18.0, 18.0

RIP1-K48{ub}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56

p37

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
884.0, 1324.5
24.10142885892533, 14.862547796337287

NS3-4A

--

e78

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p23 p57 p58

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
207.0050806221668, 154.0471732707187
921.2949652597904, 1337.7202895572173

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
221.1544764507708, 151.06433732080444
1012.8361623814133, 1458.0076622483857

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
767.0, 219.0
17.0, 17.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 16762830,11607032,14976261,14976262,11130078,15034168 Interestingly, the latter TLRs share the ability of nucleic acid recognition, detecting dsRNA (TLR3), ssRNA (TLR7 in mice, TLR8 in humans), and nonmethylated CpG DNA motifs (TLR9)

Go back
983.0, 303.0
17.0, 17.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000016573

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m14*m1572*0.1

nodelay

--

true

0

false

PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6

Go back
590.0, 334.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e18

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m1872*m18*0.1

nodelay

--

true

0

false

PMID: 16763830,16306937,16306936 Interestingly, two recent studies have used TRAF3-deficient cells to reveal this molecule as an essential intermediate transmitting antiviral responses, partly through binding to Trif and the kinases TBK1 and IKK-i

Go back
594.0, 686.0
19.0, 19.0

p11

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000016608 MO000019331

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c35 : 1
stoichiometry:c41 : 1
stoichiometry:c37 : 1

m26*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 16763830,16306937,16306936 Interestingly, two recent studies have used TRAF3-deficient cells to reveal this molecule as an essential intermediate transmitting antiviral responses, partly through binding to Trif and the kinases TBK1 and IKK-i

Go back
755.0, 999.0
17.0, 17.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 MO000007694 e31 MO000016962

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c62 : 1
stoichiometry:c133 : 1
stoichiometry:c40 : 1

m28*m977*0.1

nodelay

--

true

0

false

PMID: 16762830 To activate IRF, Trif recruits TBK1 and possibly TRAF3 PMID: 16762830,10920188,15767367 One of its proteins, A46R, is the only reported viral protein containing a TIR domain. Through the use of this domain, Vaccinia virus can inhibit Trif-mediated IRF3 activation, thereby preventing one branch of TLR3 signaling. PMID: 16762830 Another molecule, TRAF1, which is a unique NF-¦ÊB-inducible member of the TRAF family that lacks an N-terminal RING finger, also inhibits Trif signaling to both IRF3 and NF-¦ÊB.

Go back
982.0, 378.0
19.0, 19.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e23 MO000000213 MO000039077

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m25*m184*m17258*0.1

nodelay

--

true

0

false

PMID: 16762830, MyD88 recruits IRAKs through DD-DD interactions, and also TRAF3 and TRAF6, to activate IRF and NF-kB. PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6

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1030.0, 470.0
19.0, 19.0

p14

p15

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e25 MO000016963 MO000000212

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m27*m1872*m183*0.1

nodelay

--

true

0

false

PMID: 16762830, MyD88 recruits IRAKs through DD-DD interactions, and also TRAF3 and TRAF6, to activate IRF and NF-kB. PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6

Go back
842.0, 842.0
19.0, 19.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e36

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c88 : 1
stoichiometry:c52 : 1

m977*m38*0.1

nodelay

--

true

0

false

PMID: 16762830, MyD88 recruits IRAKs through DD-DD interactions, and also TRAF3 and TRAF6, to activate IRF and NF-kB. PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6 PMID: 16762830 Figure 1, Table 1

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874.0, 926.0
19.0, 19.0

p16

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e37

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c92 : 1
stoichiometry:c55 : 1

m22*m39*0.1

nodelay

--

true

0

false

PMID: 16762830, MyD88 recruits IRAKs through DD-DD interactions, and also TRAF3 and TRAF6, to activate IRF and NF-kB. PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6 PMID: 16762830 Figure 1, Table 1

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422.0, 314.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 MO000022224

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m41844*m119368*0.1

nodelay

--

true

0

false

PMID: 16762830,15208624 The recent characterization of retinoic acid inducible gene-I (RIG-I) as a cytoplasmic dsRNA receptor has defined a novel antiviral pathway and has also permitted a clearer comprehension of signals emanating from TLR-dependent and -independent antiviral mechanisms

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365.0, 389.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 MO000094908

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m31*m68199*0.1

nodelay

--

true

0

false

PMID: 16762830,16127453,16177806,16125763 To trigger antiviral responses, RIG-I recruits the adaptor CARD adaptor inducing IFN-b (Cardif, also called MAVS, IPS-1, and VISA) in a CARD-CARD-dependent manner

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851.0, 231.0
17.0, 17.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000042126

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c8 : 1

m13*m19940*0.1

nodelay

--

true

0

false

PMID: 16762830,11607032,14976261,14976262,11130078,15034168 Interestingly, the latter TLRs share the ability of nucleic acid recognition, detecting dsRNA (TLR3), ssRNA (TLR7 in mice, TLR8 in humans), and nonmethylated CpG DNA motifs (TLR9)

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486.0, 990.0
19.0, 19.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e23

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m33*m25*0.1

nodelay

--

true

0

false

PMID: 16762830,15767367 Interestingly, A46R may have a broader spectrum of effects, because it also binds three other TIR adaptors, MyD88, TIRAP (Mal), and TRAM, but not SARM, in these contexts, interfering with NF-¦ÊB and MAP kinase activation

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334.0, 758.0
19.0, 19.0

p20

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m6810*m33*0.1

nodelay

--

true

0

false

PMID: 16762830,15767367 Interestingly, A46R may have a broader spectrum of effects, because it also binds three other TIR adaptors, MyD88, TIRAP (Mal), and TRAM, but not SARM, in these contexts, interfering with NF-¦ÊB and MAP kinase activation

Go back
314.0, 890.0
19.0, 19.0

p20

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000041132

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m33*m19005*0.1

nodelay

--

true

0

false

PMID: 16762830,15767367 Interestingly, A46R may have a broader spectrum of effects, because it also binds three other TIR adaptors, MyD88, TIRAP (Mal), and TRAM, but not SARM, in these contexts, interfering with NF-¦ÊB and MAP kinase activation

Go back
410.0, 614.0
19.0, 19.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019331 MO000016608 e30 e78

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c188 : 1
stoichiometry:c75 : 1

m3902*m1599*m32*0.1

nodelay

--

true

0

false

PMID: 16762830 Mitochondrial bound Cardif in turn recruits appropriate IKKs to activate NF-kB and IRF. PMID: 16762830 After the CARD-CARD-dependent interaction with RIG-I, Cardif recruits crucial molecules that transmit downstream signaling resulting in NF-¦ÊB and IRF activation PMID: 16762830,15710891,15767399,15710892 Whereas the adaptor Trif is an NS3-4A cleavage target in the TLR3 pathway,, NS3-4A disruption of RIG-I signaling occurs in a step between RIG-I and IKKvar epsilon, because the latter kinase rescues NS3-4A-mediated blockage

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481.0, 701.0
21.0, 21.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e10 MO000007694 MO000016591

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c128 : 1
stoichiometry:c78 : 1

m10*m977*0.1

nodelay

--

true

0

false

PMID: 16762830 Mitochondrial bound Cardif in turn recruits appropriate IKKs to activate NF-kB and IRF. PMID: 16762830 After the CARD-CARD-dependent interaction with RIG-I, Cardif recruits crucial molecules that transmit downstream signaling resulting in NF-¦ÊB and IRF activation PMID: 16762830,16306043 Indeed, the overexpression of A20 dose-dependently attenuates RIG-I-induced IRF and NF-¦ÊB activation

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418.0, 514.0
19.0, 19.0

p23

p25

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000210 e30 MO000000211

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m181*m32*m182*0.1

nodelay

--

true

0

false

PMID: 16762830 Mitochondrial bound Cardif in turn recruits appropriate IKKs to activate NF-kB and IRF. PMID: 16762830 After the CARD-CARD-dependent interaction with RIG-I, Cardif recruits crucial molecules that transmit downstream signaling resulting in NF-¦ÊB and IRF activation

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341.0, 721.0
21.0, 21.0

p24

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e35 MO000000058 MO000016591

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c127 : 1
stoichiometry:c85 : 1

m37*m22*0.1

nodelay

--

true

0

false

PMID: 16762830 Mitochondrial bound Cardif in turn recruits appropriate IKKs to activate NF-kB and IRF. PMID: 16762830 After the CARD-CARD-dependent interaction with RIG-I, Cardif recruits crucial molecules that transmit downstream signaling resulting in NF-¦ÊB and IRF activation PMID: 16762830,16306043 Indeed, the overexpression of A20 dose-dependently attenuates RIG-I-induced IRF and NF-¦ÊB activation

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1011.0, 655.0
17.0, 17.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019331 MO000016608

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 16762830, MyD88 recruits IRAKs through DD-DD interactions, and also TRAF3 and TRAF6, to activate IRF and NF-kB. PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6 PMID: 16762830 Figure 1, Table 1

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1047.0, 575.0
17.0, 17.0

p27

p28

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e28 MO000000210 MO000000211

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m30*m181*m182*0.1

nodelay

--

true

0

false

PMID: 16762830, MyD88 recruits IRAKs through DD-DD interactions, and also TRAF3 and TRAF6, to activate IRF and NF-kB. PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6 PMID: 16762830 Figure 1, Table 1

Go back
486.0, 510.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e20 MO000000210 MO000000211

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m21*m181*m182*0.1

nodelay

--

true

0

false

PMID: 16762830 Figure1, Table 1

Go back
935.0, 271.0
17.0, 17.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e13

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c9 : 1

m19823*m13*0.1

nodelay

--

true

0

false

PMID: 16762830,11607032,14976261,14976262,11130078,15034168 Interestingly, the latter TLRs share the ability of nucleic acid recognition, detecting dsRNA (TLR3), ssRNA (TLR7 in mice, TLR8 in humans), and nonmethylated CpG DNA motifs (TLR9)

Go back
429.0, 1049.0
21.0, 21.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000103999 MO000022224

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m76904*m119368*0.1

nodelay

--

true

0

false

PMID: 16762830 Upon dsRNA binding, RIG-I (and also MDA5) recruits the adaptor Cardif through a CARD-CARD interaction

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330.0, 978.0
19.0, 19.0

p30

p31

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e39 MO000094908

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c192 : 1

m41*m68199*0.1

nodelay

--

true

0

false

PMID: 16762830 Upon dsRNA binding, RIG-I (and also MDA5) recruits the adaptor Cardif through a CARD-CARD interaction PMID: 16762830,16127453 Further, MDA5 may also transmit antiviral responses through Cardif,, suggesting that RIG-I- and MDA5-dependent signaling pathways converge at the adaptor level PMID: 16762830 Figure 1

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686.0, 1086.0
19.0, 19.0

p23

p32

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e40 MO000019331 MO000016608

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m42*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 16762830 Mitochondrial bound Cardif in turn recruits appropriate IKKs to activate NF-kB and IRF.

Go back
825.0, 937.0
19.0, 19.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e41 MO000007694

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m43*m977*0.1

nodelay

--

true

0

false

PMID: 16762830,15563593 Similar to RIG-I, overexpression of MDA5 leads to NF-¦ÊB and IRF activation

Go back
586.0, 990.0
19.0, 19.0

p23

p34

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e40 MO000000210 MO000000211

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m42*m181*m182*0.1

nodelay

--

true

0

false

PMID: 16762830 Mitochondrial bound Cardif in turn recruits appropriate IKKs to activate NF-kB and IRF.

Go back
330.0, 822.0
19.0, 19.0

p33

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e42 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m44*m22*0.1

nodelay

--

true

0

false

PMID: 16762830,15563593 Similar to RIG-I, overexpression of MDA5 leads to NF-¦ÊB and IRF activation

Go back
338.0, 218.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e43 MO000022224

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m45*m119368*0.1

nodelay

--

true

0

false

PMID: 16762830,16210631,16116171 A third RIG-I-like RNA helicase, Lgp2, was recently demonstrated to bind dsRNA

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1070.0, 1070.0
19.0, 19.0

p37

p37

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

e77

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c126 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 16762830,15258597 These activities therefore target RIP1 for proteasome-dependent degradation

Go back
925.0, 861.0
21.0, 21.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000204 MO000000058 MO000000065

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m175*m22*m20*0.1

nodelay

--

true

0

false

PMID: 16762830,9529147 TNF-induced NF-¦ÊB activation relies on the DD kinase RIP1

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946.0, 782.0
19.0, 19.0

p39

p39

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

MO000016591 MO000041125

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m1585*m18998*0.1

nodelay

--

true

0

false

PMID: 16762830,16306043,15474016 Further, A20 may also downregulate TLR3-dependent responses, possibly through targeting Trif for degradation

Go back
1043.0, 527.0
17.0, 17.0

p1

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19828*m16*0.1

nodelay

--

true

0

false

PMID: 16762830,11607032,14976261,14976262,11130078,15034168 Interestingly, the latter TLRs share the ability of nucleic acid recognition, detecting dsRNA (TLR3), ssRNA (TLR7 in mice, TLR8 in humans), and nonmethylated CpG DNA motifs (TLR9)

Go back
730.0, 1134.0
19.0, 19.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e46 MO000007694

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m48*m977*0.1

nodelay

--

true

0

false

PMID: 16762830 SIKE interacts with both IRF3/7 kinases, IKKvar epsilon, and TBK1 and most probably sequesters them away from IRF3 and the adaptor Trif (and maybe Cardif as well).

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558.0, 1166.0
19.0, 19.0

p40

p41

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e46 MO000007702

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m48*m980*0.1

nodelay

--

true

0

false

PMID: 16762830 SIKE interacts with both IRF3/7 kinases, IKKvar epsilon, and TBK1 and most probably sequesters them away from IRF3 and the adaptor Trif (and maybe Cardif as well).

Go back
786.0, 1114.0
19.0, 19.0

p40

p42

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e46 MO000019331

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m48*m3902*0.1

nodelay

--

true

0

false

PMID: 16762830 SIKE interacts with both IRF3/7 kinases, IKKvar epsilon, and TBK1 and most probably sequesters them away from IRF3 and the adaptor Trif (and maybe Cardif as well).

Go back
790.0, 978.0
19.0, 19.0

p40

p43

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e46 MO000016608

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m48*m1599*0.1

nodelay

--

true

0

false

PMID: 16762830 SIKE interacts with both IRF3/7 kinases, IKKvar epsilon, and TBK1 and most probably sequesters them away from IRF3 and the adaptor Trif (and maybe Cardif as well).

Go back
679.0, 1307.0
17.0, 17.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000103999 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m76904*m67*0.1

nodelay

--

true

0

false

PMID: 16762830,15563593 The V proteins of different ssRNA paramyxoviruses, including SeV, have recently been reported to bind to and inhibit MDA5-dependent type-I IFN production

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622.0, 1102.0
19.0, 19.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e26 MO000007702

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m28*m980*0.1

nodelay

--

true

0

false

PMID: 16762830,14517278,12539043,12471095 Trif signaling leads to IRF3 and IRF7 activation and type-I IFN production

Go back
303.0, 1243.0
17.0, 17.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e48 e67 e66

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c156 : 1
stoichiometry:c167 : 1
stoichiometry:c157 : 1

m63*m69*0.1

nodelay

--

true

0

false

PMID: 16762830,14517278,12539043,12471095 Trif signaling leads to IRF3 and IRF7 activation and type-I IFN production PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6 PMID: 16762830 Figure 1, Table 1 PMID: 16762830,15563593 The V proteins of different ssRNA paramyxoviruses, including SeV, have recently been reported to bind to and inhibit MDA5-dependent type-I IFN production

Go back
303.0, 1327.0
17.0, 17.0

p46

p47

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e27 e67 e66

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c168 : 1
stoichiometry:c158 : 1

m29*m69*0.1

nodelay

--

true

0

false

PMID: 16762830,14517278,12539043,12471095 Trif signaling leads to IRF3 and IRF7 activation and type-I IFN production PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6 PMID: 16762830 Figure 1, Table 1 PMID: 16762830,15563593 The V proteins of different ssRNA paramyxoviruses, including SeV, have recently been reported to bind to and inhibit MDA5-dependent type-I IFN production

Go back
914.0, 938.0
19.0, 19.0

p16

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000007702

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m38*m980*0.1

nodelay

--

true

0

false

PMID: 16762830, MyD88 recruits IRAKs through DD-DD interactions, and also TRAF3 and TRAF6, to activate IRF and NF-kB. PMID:16762830 To promote type-I IFN production in pDCs, TLR7 most probably utilizes MyD88, IL-1R associated kinase (IRAK)-1, TRAF3 and TRAF6 PMID: 16762830 Figure 1, Table 1

Go back
497.0, 909.0
21.0, 21.0

p24

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e10 MO000007702

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c140 : 1
stoichiometry:c163 : 1

m10*m980*0.1

nodelay

--

true

0

false

PMID: 16762830 Mitochondrial bound Cardif in turn recruits appropriate IKKs to activate NF-kB and IRF. PMID: 16762830 After the CARD-CARD-dependent interaction with RIG-I, Cardif recruits crucial molecules that transmit downstream signaling resulting in NF-¦ÊB and IRF activation PMID: 16762830,16306043 Indeed, the overexpression of A20 dose-dependently attenuates RIG-I-induced IRF and NF-¦ÊB activation

Go back
642.0, 322.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000041125

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m12*m18998*0.1

nodelay

--

true

0

false

PMID: 16762830,12872135,12471095,12855817 Although most TLRs recruit MyD88 to transmit antimicrobial responses, the elucidation of TLR3 signaling arose from the finding that TLR3 recruits Trif, but no other TIR adaptor, to mediate antiviral responses

Go back
822.0, 1226.0
19.0, 19.0

p33

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e41 MO000007702

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m43*m980*0.1

nodelay

--

true

0

false

PMID: 16762830,15563593 Similar to RIG-I, overexpression of MDA5 leads to NF-¦ÊB and IRF activation

Go back
623.0, 231.0
17.0, 17.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000008179 MO000022224

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m1055*m119368*0.1

nodelay

--

true

0

false

PMIFD: 16762830,1695551 The first depends on protein kinase R (PKR). This IFN-inducible kinase becomes activated following binding to cytoplasmic dsRNA that results in the phosphorylation of eukaryotic translation initiation factor (eIF2)-alpha

Go back
478.0, 250.0
19.0, 19.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e70 MO000008179

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c173 : 1

m72*m1055*0.1

nodelay

--

true

0

false

--

Go back
882.0, 210.0
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022224 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m119368*m74*0.1

nodelay

--

true

0

false

PMID: 16762830 A second protein that is stimulated by dsRNA is 2¡ì?5¡ì oligoadenylate synthetase, an enzyme that activates the endoribonuclease RNase L through the synthesis of short oligoadenylates.

Go back
1078.0, 726.0
19.0, 19.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e73 e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m75*m76*0.1

nodelay

--

true

0

false

PMID: 16762830 A second protein that is stimulated by dsRNA is 2¡ì?5¡ì oligoadenylate synthetase, an enzyme that activates the endoribonuclease RNase L through the synthesis of short oligoadenylates

Go back
1025.0, 693.0
17.0, 17.0

p55

p55

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytoplasm

--

MO000016591 MO000000065

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m1585*m20*0.1

nodelay

--

true

0

false

PMID: 16762830 A20 bears both ubiquitin ligase and deubiquitinase activities that prevent prolonged TNF-induced NF-¦ÊB activation by firstly removing K63-linked RIP1 ubiquitin chains that are required for signaling and by secondly promoting K48-linked ubiquitin chains.

Go back
1099.0, 1099.0
17.0, 17.0

p56

p56

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 16762830 A20 bears both ubiquitin ligase and deubiquitinase activities that prevent prolonged TNF-induced NF-¦ÊB activation by firstly removing K63-linked RIP1 ubiquitin chains that are required for signaling and by secondly promoting K48-linked ubiquitin chains.

Go back
928.0, 1220.0
20.0, 20.0

p57

p57

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e78 MO000041125

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m80*m18998*0.1

nodelay

--

true

0

false

PMID: 16762830,15710891,15767399,15710892 Whereas the adaptor Trif is an NS3-4A cleavage target in the TLR3 pathway,, NS3-4A disruption of RIG-I signaling occurs in a step between RIG-I and IKKvar epsilon, because the latter kinase rescues NS3-4A-mediated blockage

Go back
754.0, 1042.0
19.0, 19.0

p58

p58

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e78 MO000094908

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m80*m68199*0.1

nodelay

--

true

0

false

PMID: 16762830,16177806 Importantly, under such conditions of a productive HCV infection, Cardif is also cleaved by NS3-4A

Go back
658.0, 402.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000000212

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m18*m183*0.1

nodelay

--

true

0

false

PMID: 16762830,12609980,14530355 First, Trif recruits tumor necrosis factor receptor (TNF-R) associated factor (TRAF)-6 by means of its N-terminal region

Go back
522.0, 550.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000000065 e22

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c28 : 1
stoichiometry:c21 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID: 16762830,11734559, Second, Trif contains a C-terminal RIP homotypic interaction motif (RHIM; that interacts with the RHIM of both receptor interacting protein (RIP)-1 and RIP3 kinases that interacts with the RHIM of both receptor interacting protein (RIP)-1 and RIP3 kinases PMID: 16762830 RIP3 may inhibit NF-¦ÊB activation by destabilizing Trif-RIP1 interaction.

Go back
631.0, 599.0
17.0, 17.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e38 MO000016962

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c22 : 1
stoichiometry:c132 : 1
stoichiometry:c24 : 1

m22*m40*0.1

nodelay

--

true

0

false

PMID: 16762830,15064760,16115877 Whereas RIP1 transmits Trif-induced NF-¦ÊB activation, RIP3 appears to bear regulatory functions PMID: 16762830 Another molecule, TRAF1, which is a unique NF-¦ÊB-inducible member of the TRAF family that lacks an N-terminal RING finger, also inhibits Trif signaling to both IRF3 and NF-¦ÊB.

Go back
669.0, 521.0
21.0, 21.0

p7

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019241 e19

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c25 : 1
stoichiometry:c27 : 1

m3825*m19*0.1

nodelay

--

true

0

false

PMID: 16762830,11734559, Second, Trif contains a C-terminal RIP homotypic interaction motif (RHIM; that interacts with the RHIM of both receptor interacting protein (RIP)-1 and RIP3 kinases that interacts with the RHIM of both receptor interacting protein (RIP)-1 and RIP3 kinases

Go back
776.0, 112.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.0, 536.3330443576974

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.023697945709, 1003.2259504455368

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 382.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 1068.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.0, 602.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 653.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.0, 1096.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.4545490482494, 963.9870761335256

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.0, 821.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.7860670041675, 908.837705255642

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1067.8360815016774, 490.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.8089875327071, 1016.4906334205524

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.0, 366.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 449.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.04079188982547, 916.7983219405637

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.9236425126522, 845.3768447422535

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.6241211170791, 740.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 825.4607722807733

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
300.0, 239.63365705751355

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.66829085023244, 104.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
355.0, 237.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
956.4440852160341, 539.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.9994087923652, 868.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
651.0, 741.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.9585272113607, 825.8135383371613

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 421.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1081.7434356128128, 1096.9653815658512

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.0, 1247.3974247877977

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1019.923410283849, 1045.0082901643336

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.7816167141927, 736.3036007927807

c127

c127

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
505.61699458698394, 718.7080252216313

c128

c128

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
961.6810752943748, 808.5373626200345

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.9101363936425, 334.1957182920622

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.0, 412.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
958.0, 801.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.412433099487, 619.1906373251279

c132

c132

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
775.690515245031, 1012.5427563729228

c133

c133

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
756.6267378028059, 1149.4151336375553

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
663.0, 824.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.0, 1153.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.9932530560083, 1176.3284898516167

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 1118.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 1151.849491276741

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 347.6564023547028

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.6643638388299, 937.972366065959

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.3520444365522, 1135.8632840217354

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.0, 602.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.0, 1125.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
806.9641233275337, 1004.4306105334065

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 651.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 990.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.0, 1130.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
704.0, 1316.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 1324.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.0, 337.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.7803454170266, 798.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
534.0, 1108.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 1121.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
327.9945856513575, 1240.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
323.9526924417301, 916.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
327.94936942418695, 1322.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
327.1925502549497, 1259.5024592545842

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.57044805972893, 1255.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
149.92634145408897, 1314.083102558944

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.0, 707.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
684.7748008455096, 394.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 954.9711254108329

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.414582645777, 957.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 571.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
513.0, 930.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.6990699817187, 1112.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
534.0, 1112.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.9973714472759, 1236.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.7371257727902, 1256.426145489895

c167

c167

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
323.950515066143, 1337.6272405536772

c168

c168

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
567.0, 233.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 417.04123408984816

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.7488171341328, 112.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0, 245.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.0, 240.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.0, 269.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.38461538461536, 236.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.0, 112.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.7133822316919, 224.12220040237025

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 225.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1088.2538403746782, 348.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1097.1488985922153, 751.8400760574362

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 415.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1088.0, 745.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.0, 717.9822812628529

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.0, 417.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.0, 710.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 1033.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1097.6482675660702, 1116.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 412.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 1052.5675675675675

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.2309648939423, 636.3200595841034

c188

c188

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
771.4010917717399, 1068.2410340946722

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
548.1134997064896, 449.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
307.0, 382.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.0, 1037.503504292288

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.0, 990.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.514289298112, 243.85537573395592

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.0, 421.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.0, 497.3056055099479

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 608.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 624.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.04355418997744, 616.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.2360065580478, 454.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 528.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 533.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.9923471807771, 545.0

c28

c28

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
881.0, 317.2573305919324

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.3564163240852, 236.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.0, 222.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.3460102252582, 320.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.0, 345.57680809740106

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.6338097114049, 349.3926866259627

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 353.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.0, 646.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.9533792209977, 697.8624146143251

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.0, 700.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.5238197468426, 798.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
666.0, 824.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.5305193394914, 113.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
669.8463052809356, 920.4608346030717

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 595.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.0, 374.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 388.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.6568542494924, 402.65685424949237

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.5699763999032, 397.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.0, 485.0872722011422

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.0, 354.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 456.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.7777713001234, 489.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.0, 255.5643006869286

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.0, 593.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
672.0, 814.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.7455388954588, 855.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
961.0, 593.0209636589963

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0, 745.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.73180588474014, 829.054063718753

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.9978624628054, 320.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.7070744721117, 108.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 324.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.0, 335.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 295.985695883279

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
310.0, 376.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.13661496121927, 409.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 867.0

c62

c62

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
460.0, 877.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.71294411713103, 381.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 773.1052757931725

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.0, 768.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0740528189224, 781.2063309876478

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
327.9373322778884, 727.4412417706505

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.7043898780539, 865.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 113.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 916.4404159196479

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.0, 908.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 594.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 629.0359463942372

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
310.0, 478.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 578.3795279064104

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 571.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.87237195430697, 722.0951805481144

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 722.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.2161372907833, 366.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 248.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.0, 469.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 449.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.9961568483941, 520.2479428480123

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.0, 535.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.999102396878, 732.1198367400282

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.0, 740.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.0, 644.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.8025063917887, 666.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
857.1146094037645, 707.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
442.0, 360.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
927.115466760049, 288.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.0, 442.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.9861949854, 585.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.0, 611.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.9542242014454, 493.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 366.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 445.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 522.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.0, 1071.437601569802

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.643162344584, 112.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.0, 1070.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back