1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16846591.csml convertedTime:2009.07.01.10:56

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and controlof anti-tumor activity in primary macrophages.
Authors Solis M, Goubau D, Romieu-Mourez R, Genin P, Civas A, Hiscott J.
Affiliation Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research,McGill University, Montreal, Canada H3T 1E2.
Abstract Type I IFN (IFN-alpha/beta) have important biological functions ranging fromimmune cell development and activation, to tumor cell killing and mostimportantly inhibition of virus replication. Following viral infection oractivation of Toll-like receptors (TLRs) via distinct ligands, IFN-alpha/betaare produced. Two members of the interferon regulatory factor (IRF) family -IRF-3 and IRF-7 - are the major modulators of IFN gene expression. Activation ofIRF-3 and IRF-7 by TBK1/IKKvarepsilon mediated phosphorylation promotes IFN geneexpression and potentiates the production of IFN responsive genes important tothe development of an effective antiviral immune response. IFN treatment canaugment anti-tumor properties and they are potentially key players in cancertherapy. For example, adoptive transfer of IFN-gamma-activated macrophages canmediate tumor cell killing via direct cell-cell contact, as well as release ofsoluble cytotoxic pro-inflammatory molecules. A recent study investigatedwhether IRF-3 and IRF-7 could mediate the acquisition of new anti-tumor effectorfunctions in macrophages. Adenovirus mediated transduction of the active form ofIRF-7 into primary macrophages resulted in the production of type I IFN,upregulation of target genes including TRAIL and increased tumoricidal activityof macrophages; in contrast, the active form of IRF-3 led to induction of celldeath. These studies indicate that IRF-7 transduced macrophages may be anattractive candidate for in vivo adoptive therapy of cancer.
PMID 16846591
Model Abstract

Entity

G000307:IFNA1(h) G009107:IFNA4(m) G010228:IFN-beta G010432:p53 G010514:iNOS MO000000058:NF-kappaB MO000000062:ATF-2 MO000000210:IKK-alpha MO000000212:TRAF6 MO000000214:IL-1 MO000007694:IRF-3 MO000007702:IRF-7 MO000008179:PKR MO000016573:MyD88 MO000016608:IKK-i MO000016656:STATs MO000016660:IFNbeta MO000016665:IFNgamma MO000016882:LPS MO000017462:CBP MO000019331:TBK1 MO000019394:TLR4 MO000019398:TLR3 MO000022224:dsRNA MO000039077:IRAK-4 MO000041446:dsRNA:TLR3 MO000041457:IRF-7{p} MO000042007:TLR8 MO000042012:TLR9 MO000042127:TLR7(h) MO000116973:IFNalpha1(h) e1: e10:IFNgamma:TypeII IFN receptor e11:ISGs e12:RNase L e13:OAS e14: e15: e16: e17:LPS:TLR4 e18:IRF-3{p} e19:IRF-3{p}:IRF-3{p} e2: e20:IRF-3{p}:IRF-3{p} e21:IRF-3{p}:IRF-3{p}:CBP e22:IFNalpha1:Type I IFN receptor e23:JAK e24:JAK{active} e25:STATs{active} e26:IRF-7{p}:IRF-7{p} e27:IRF-7{p}:IRF-3{p} e28:IRF-7{p}:IRF-7{p} e29:IRF-7{p}:IRF-3{p} e3: e30:IFN-alpha e31:IRF-7{p}:IRF-7{p}:IFN-alpha e32:IRF-7{p}:IRF-3{p}:IFN-alpha e33:IFN-alpha e34:FCgammaR e35:TRAIL e36:NF-kappaB{active} e37:IL-1 e38:ATF-2{active} e39:CpG DNA e4: e40:TLR9:CpG DNA e41:ssRNA e42:ssRNA:TLR7 e43:ssRNA:TLR8 e44:TLR9:CpGDNA:MyD88 e45:ssRNA:TLR7:MyD88 e46:TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6 e47:TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6 e48:TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha e49:TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha e5:IFNalpha e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Type I IFN receptor e60: e61: e62: e63:TLR9:CpGDNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha e64:TLR7:ssRNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha e65:ISGF3 e66:PKR e67:ISGF3:PKR e68:OAS e69:ISGF3:OAS e7:IFNbeta:Type I IFN receptor e70:IRF-7 e71:ISGF3:IRF-7 e8:IFNalpha:Type I IFN receptor e9:Type II IFN receptor

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p7 p8 p9
Model Detail
813.0, 941.0
22.0, 22.0

IFNA1(h)

--

G000307

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

p21

true true true true

csml-variable:Double

m87546

10

false

infinite

0

unit false false false
Affymetrix1666_at
EnsemblENSG00000197919
HGNCIFNA13
OMIM147660
ProteomeHumanPSD/IFNA1
RefSeqNM_024013
TRANSFACG000307
UnigeneHs.37026

--

Go back
856.0, 1047.0
18.0, 18.0

IFNA4(m)

--

G009107

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

--

true true true true

csml-variable:Double

m92400

10

false

infinite

0

unit false false false
Affymetrix101789_i_at
EnsemblENSMUSG00000070904
MGDIfna4
ProteomeHumanPSD/Ifna4
RefSeqNM_010504
TRANSFACG009107
UnigeneMm.377088

--

Go back
909.0, 948.0
24.0, 24.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p16 p35 p36 p59 p60

p20

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
939.0, 926.0
20.0, 20.0

p53

--

G010432

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p42

--

true true true true

csml-variable:Double

m93404

10

false

infinite

0

unit false false false
TRANSFACG010432

--

Go back
846.0, 837.0
22.0, 22.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
263.0, 746.0
20.0, 20.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p43

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
464.0, 599.0
18.0, 18.0

ATF-2

--

MO000000062

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p45

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000000062

--

Go back
402.0, 841.0
22.0, 22.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p54

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
672.0, 515.0
18.0, 18.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1158.0, 765.0
22.0, 22.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

--

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
294.0, 749.0
22.0, 22.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
522.0, 177.0
21.5, 21.5

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p51 p52

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
513.0, 584.0
23.0, 23.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
418.0, 161.0
22.0, 22.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p50

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
571.0, 226.0
20.0, 20.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
885.0, 412.0
16.0, 16.0

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
667.0, 26.0
19.0, 19.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p1

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
354.0, 21.0
21.0, 21.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
127.0, 490.0
20.0, 20.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
528.0, 983.0
25.0, 25.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
623.0, 246.0
20.0, 20.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
203.0, 438.0
20.0, 20.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
288.0, 199.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
142.0, 225.0
22.0, 22.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
696.0, 403.0
18.0, 18.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
407.0, 358.0
19.0, 19.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p12 p26 p43 p44

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
642.0, 309.0
22.0, 22.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p19 p28

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
260.0, 219.0
18.0, 18.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
305.0, 160.0
16.0, 16.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
280.0, 403.0
18.0, 18.0

TLR7(h)

--

MO000042127

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m155901

10

false

infinite

0

unit false false false
Affymetrix220146_at
EnsemblENSG00000196664
HGNCTLR7
OMIM300365
ProteomeHumanPSD/TLR7
RefSeqNM_016562
TRANSPATHMO000042127
UnigeneHs.102488
UniProtQ9NYK1

--

Go back
1124.0, 360.0
24.0, 24.0

IFNalpha1(h)

--

MO000116973

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p22

true true true true

csml-variable:Double

m360227

10

false

infinite

0

unit false false false
Affymetrix1666_at
EnsemblENSG00000197919
HGNCIFNA13
InterProIPR000471
OMIM147660
ProteomeHumanPSD/IFNA1
RefSeqNM_024013
TRANSPATHMO000116973
UnigeneHs.37026
UniProtP01562

--

Go back
173.75, 86.99690800911759
923.8565131236157, 1341.439657055489

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
463.5, 95.0
17.848278886209165, 34.54505590879194

IFNgamma:TypeII IFN receptor

--

e10

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

p37 p38 p39 p40

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
688.0, 813.0
42.30103806228373, 22.560553633217996

ISGs

--

e11

cso30:c:mRNA

cso30:i:CC_NuclearChromosome

--

p4 p5

p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
508.5, 543.0
16.448581203461462, 26.673374924532105

RNase L

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

p6

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
510.0, 468.0
13.510757717492986, 31.178671655753043

OAS

--

e13

cso30:c:Protein

cso30:i:CC_Extracellular

--

p8

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
255.05450097661807, 159.73234976200868
212.77056112870434, 355.2186486640239

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
255.05450097661807, 159.73234976200868
212.77056112870434, 355.2186486640239

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
255.05450097661807, 159.73234976200868
212.77056112870434, 355.2186486640239

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
198.5, 492.0
20.29511072133304, 39.2808594606446

LPS:TLR4

--

e17

cso30:c:Complex

cso30:i:CC_Extracellular

--

p10

p11 p27 p45

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
378.0, 677.0
22.0, 22.0

IRF-3{p}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p12

p13 p28

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
311.5, 808.0
19.278286952174643, 23.606065655724052

IRF-3{p}:IRF-3{p}

--

e19

cso30:c:Complex

cso30:i:CC_Extracellular

--

p13

p14

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
179.1447231381399, 102.75225207009211
921.17954813941, 1337.5527038984217

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
603.5, 1040.0
19.278286952174643, 23.606065655724052

IRF-3{p}:IRF-3{p}

--

e20

cso30:c:Complex

cso30:i:CC_Extracellular

--

p14

p15

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
795.5, 979.0
18.473664892640866, 25.77720682694074

IRF-3{p}:IRF-3{p}:CBP

--

e21

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p15

p16 p17 p18

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1050.5, 292.0
20.267923700942774, 39.228239421179566

IFNalpha1:Type I IFN receptor

--

e22

cso30:c:Complex

cso30:i:CC_Extracellular

--

p22

p25

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
599.0, 192.5
20.959999999999997, 15.719999999999999

JAK

--

e23

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p23 p25

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
711.0, 248.5
20.959999999999997, 15.719999999999999

JAK{active}

--

e24

cso30:c:Protein

cso30:i:CC_Extracellular

--

p23 p25

p24

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
865.0, 456.0
16.0, 16.0

STATs{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

--

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
735.5, 485.0
18.706715547408756, 22.9061823029495

IRF-7{p}:IRF-7{p}

--

e26

cso30:c:Complex

cso30:i:CC_Extracellular

--

p19

p29

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
622.5, 515.0
20.527578736877192, 25.13581069821696

IRF-7{p}:IRF-3{p}

--

e27

cso30:c:Complex

cso30:i:CC_Extracellular

--

p28

p30

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
643.5, 713.0
18.706715547408756, 22.9061823029495

IRF-7{p}:IRF-7{p}

--

e28

cso30:c:Complex

cso30:i:CC_Extracellular

--

p29

p31

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
606.5, 731.0
20.527578736877192, 25.13581069821696

IRF-7{p}:IRF-3{p}

--

e29

cso30:c:Complex

cso30:i:CC_Extracellular

--

p30

p32

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
192.22713026247231, 105.4740382715899
886.9022525986711, 1304.485396530545

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
748.0, 802.5
49.4613955956487, 10.716635712390556

IFN-alpha

--

e30

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p31 p32

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
598.0, 788.5
53.13448187194652, 15.054769863718182

IRF-7{p}:IRF-7{p}:IFN-alpha

--

e31

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p31

p33 p35

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
716.0, 776.5
50.480843404474165, 14.30290563126768

IRF-7{p}:IRF-3{p}:IFN-alpha

--

e32

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p32

p34 p36

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
734.0, 1062.0
37.47404844290658, 19.986159169550174

IFN-alpha

--

e33

cso30:c:mRNA

cso30:i:CC_Extracellular

--

p33 p34 p57 p61

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
904.0, 1003.0
33.529411764705884, 17.88235294117647

FCgammaR

--

e34

cso30:c:mRNA

cso30:i:CC_Extracellular

--

p38

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
937.0, 869.0
39.44636678200692, 21.038062283737023

TRAIL

--

e35

cso30:c:mRNA

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
335.0, 706.0
20.0, 20.0

NF-kappaB{active}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27 p43

--

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
843.0, 867.0
34.878892733564015, 18.602076124567475

IL-1

--

e37

cso30:c:mRNA

cso30:i:CC_Extracellular

--

p40

p41

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
464.0, 655.0
18.0, 18.0

ATF-2{active}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44 p45

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000000062

--

Go back
110.0, 157.0
53.40248962655602, 14.240663900414937

CpG DNA

--

e39

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p46

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
226.40982124804623, 137.80901623091628
818.5368706275239, 1239.8154406118917

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
356.5, 187.0
17.209383907037928, 33.30848498136373

TLR9:CpG DNA

--

e40

cso30:c:Complex

cso30:i:CC_Extracellular

--

p46

p49

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
114.0, 322.5
37.68910326682746, 19.472703354527514

ssRNA

--

e41

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p47 p48

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
280.5, 455.0
17.20938390703793, 33.30848498136373

ssRNA:TLR7

--

e42

cso30:c:Complex

cso30:i:CC_Extracellular

--

p47

p50

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
269.5, 333.0
15.408243806182856, 29.822407366805535

ssRNA:TLR8

--

e43

cso30:c:Complex

cso30:i:CC_Extracellular

--

p48

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
396.5, 237.0
16.35089007157278, 22.8151954487062

TLR9:CpGDNA:MyD88

--

e44

cso30:c:Complex

cso30:i:CC_Extracellular

--

p49

p51

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
323.5, 434.0
19.728390530372547, 27.527986786566355

ssRNA:TLR7:MyD88

--

e45

cso30:c:Complex

cso30:i:CC_Extracellular

--

p50

p52

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
349.0, 378.0
16.500000000000004, 27.500000000000007

TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6

--

e46

cso30:c:Complex

cso30:i:CC_Extracellular

--

p51

p53 p57 p59

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
364.0, 266.0
16.500000000000004, 27.500000000000007

TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6

--

e47

cso30:c:Complex

cso30:i:CC_Extracellular

--

p52

p54

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
417.0, 318.0
16.500000000000004, 27.500000000000007

TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha

--

e48

cso30:c:Complex

cso30:i:CC_Extracellular

--

p53

p55

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
300.0, 282.0
16.500000000000004, 27.500000000000007

TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha

--

e49

cso30:c:Complex

cso30:i:CC_Extracellular

--

p54

p56

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
816.0, 24.5
25.296840410545386, 15.599718253169655

IFNalpha

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
469.86087209678476, 656.6403913703671
530.4624594225338, 481.07116897350886

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
527.1547690176542, 668.0410787075648
310.17730401988024, 466.25378183880133

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
476.7756527596485, 663.0612591287405
516.632898096807, 468.22943345676214

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
477.76347856862907, 664.049084937721
514.6572464788457, 466.25378183880133

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
469.86087209678476, 656.6403913703671
530.4624594225338, 481.07116897350886

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
469.86087209678476, 656.6403913703671
530.4624594225338, 481.07116897350886

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
477.76347856862907, 664.049084937721
514.6572464788457, 466.25378183880133

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
857.0885892171441, 854.2055531664691
33.14037983657559, 30.000764904689543

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
770.1599180268598, 992.5011664237409
93.84345185314842, 84.95301957232401

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
469.86087209678476, 656.6403913703671
530.4624594225338, 481.07116897350886

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
729.5, 110.0
22.755711775043928, 35.00878734622142

Type I IFN receptor

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1 p2 p22

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
594.8878890758582, 870.4244437384003
16.798966657202147, 8.088391353467717

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
594.3269240283287, 846.3029466946252
57.498917371790036, 103.49805126922217

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
618.4484210721043, 913.6187523981847
8.975440760474534, 8.975440760474548

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
317.0, 358.0
16.500000000000004, 27.500000000000007

TLR9:CpGDNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha

--

e63

cso30:c:Complex

cso30:i:CC_Extracellular

--

p55

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
380.0, 290.0
16.500000000000004, 27.500000000000007

TLR7:ssRNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha

--

e64

cso30:c:Complex

cso30:i:CC_Extracellular

--

p56

p60 p61

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
513.0, 850.0
16.323529411764707, 27.20588235294118

ISGF3

--

e65

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p58 p62 p63

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
467.0, 909.5
57.30963120191032, 12.417086760413902

PKR

--

e66

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
576.0, 932.5
49.987143224479304, 14.163023913602467

ISGF3:PKR

--

e67

cso30:c:Complex

cso30:i:CC_Extracellular

--

p58

p7

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
804.0, 770.5
50.034491907667814, 10.840806579994693

OAS

--

e68

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p62

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
572.0, 828.5
50.48084340447416, 14.30290563126768

ISGF3:OAS

--

e69

cso30:c:Complex

cso30:i:CC_Extracellular

--

p62

p8

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
614.5, 109.0
19.649418987064244, 38.03113352335016

IFNbeta:Type I IFN receptor

--

e7

cso30:c:Complex

cso30:i:CC_Extracellular

--

p1

p5 p23 p42

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
766.0, 734.5
53.98248872379942, 11.69620589015654

IRF-7

--

e70

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p63

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
939.0, 836.5
49.58601182823348, 14.049370017999486

ISGF3:IRF-7

--

e71

cso30:c:Complex

cso30:i:CC_Extracellular

--

p63

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
891.5, 106.0
18.92216619162464, 36.623547467660615

IFNalpha:Type I IFN receptor

--

e8

cso30:c:Complex

cso30:i:CC_Extracellular

--

p2

p4

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
273.5, 107.0
22.34446397188049, 34.376098418277664

Type II IFN receptor

--

e9

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
610.0, 57.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000016660

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c1 : 1
stoichiometry:c3 : 1

m6*m1636*0.1

nodelay

--

true

0

false

PMID: 16846592,15864272 The IFN proteins group into two classes: type I (IFN-greek small letter alpha and -¦Â) and type II (IFN-¦Ã), which bind two distinct cell surface receptors, type I and type II IFN receptors, respectively PMID: 16846591 Binding of the newly secreted IFN-¦Â and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.

Go back
127.0, 438.0
19.0, 19.0

p9

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun

Go back
362.0, 545.0
21.0, 21.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e17 MO000007694

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m17*m977*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun PMID: 16846591 The production of IFN-¦Â relies in part on the C-terminal phosphorylation and activation of the cytoplasmic interferon regulatory factor (IRF)-3 transcription factor PMID: 16846591 he C-terminal region comprises a cluster of phosphoacceptor sites 382GGASSLENTVDLHISNSHPLSLTSDQYKAYLQD414 and virus-induced phosphorylation is thought to realign the C-terminal domain and relieve autoinhibition

Go back
290.0, 513.0
21.0, 21.0

p11

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000041446 MO000007694

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m19314*m977*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun PMID: 16846591 The production of IFN-¦Â relies in part on the C-terminal phosphorylation and activation of the cytoplasmic interferon regulatory factor (IRF)-3 transcription factor PMID: 16846591 he C-terminal region comprises a cluster of phosphoacceptor sites 382GGASSLENTVDLHISNSHPLSLTSDQYKAYLQD414 and virus-induced phosphorylation is thought to realign the C-terminal domain and relieve autoinhibition

Go back
378.0, 737.0
21.0, 21.0

p13

p13

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 16846591 Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-¦Â and human IFN-alpha1 (or murine IFN-alpha4) promoters

Go back
494.0, 705.0
21.0, 21.0

p14

p14

cso30:i:ME_Translocation

cso30:i:CC_Extracellular

--

e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 16846591 Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-¦Â and human IFN-alpha1 (or murine IFN-alpha4) promoters

Go back
639.0, 998.0
19.0, 19.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e20 MO000017462

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m20*m2282*0.1

nodelay

--

true

0

false

PMID: 16846591 Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-¦Â and human IFN-alpha1 (or murine IFN-alpha4) promoters

Go back
811.0, 846.0
19.0, 19.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 16846591 Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-¦Â and human IFN-alpha1 (or murine IFN-alpha4) promoters

Go back
855.0, 990.0
19.0, 19.0

p16

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G000307

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 16846591 Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-¦Â and human IFN-alpha1 (or murine IFN-alpha4) promoters

Go back
791.0, 1062.0
19.0, 19.0

p16

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G009107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 16846591 Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-¦Â and human IFN-alpha1 (or murine IFN-alpha4) promoters

Go back
719.0, 330.0
19.0, 19.0

p19

p19

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

MO000041457

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
890.0, 45.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 e6

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 16846592,15864272 The IFN proteins group into two classes: type I (IFN-greek small letter alpha and -¦Â) and type II (IFN-¦Ã), which bind two distinct cell surface receptors, type I and type II IFN receptors, respectively

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822.0, 601.0
21.0, 21.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 16846591 Binding of the newly secreted IFN-¦Â and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.

Go back
974.0, 709.0
21.0, 21.0

p20

p21

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G000307

MO000116973

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m87546*0.1

nodelay

--

true

0

false

PMID: 16846591 Binding of the newly secreted IFN-¦Â and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.

Go back
1126.0, 301.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e6 MO000116973

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m6*m360227*0.1

nodelay

--

true

0

false

PMID: 16846591 Binding of the newly secreted IFN-¦Â and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.

Go back
704.0, 187.0
17.0, 17.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e7 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m7*m23*0.1

nodelay

--

true

0

false

PMID: 16846591 Binding of the newly secreted IFN-¦Â and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.

Go back
804.0, 451.0
17.0, 17.0

p23

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e24 MO000016656

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m24*m1633*0.1

nodelay

--

true

0

false

PMID: 16846591 Binding of the newly secreted IFN-¦Â and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.

Go back
848.0, 211.0
17.0, 17.0

p23

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e22 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID: 16846591 Binding of the newly secreted IFN-¦Â and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.

Go back
551.0, 318.0
19.0, 19.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000041446 MO000007702 MO000019331 MO000016608

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c63 : 1

m19314*m980*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 16846591,15743772,10938111 Similarly to IRF-3, IRF-7 is activated by virus-induced phosphorylation at its C-terminus PMID: 16846591,10938111,11073981,9877175,12702806,15367631 The serine rich C-terminal region between aa471?487, is the target of virus-induced phosphorylation and by TBK1 and IKK epsilon

Go back
338.0, 585.0
21.0, 21.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e17 MO000000058

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m17*m36*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun

Go back
552.0, 427.0
18.0, 18.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041457 e18

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m19325*m18*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
619.0, 634.0
19.0, 19.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
275.0, 50.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016665 e9

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m1639*m9*0.1

nodelay

--

true

0

false

Go back
575.0, 642.0
19.0, 19.0

p29

p30

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
692.0, 699.0
17.0, 17.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e28 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m28*m30*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
728.0, 723.0
17.0, 17.0

p31

p32

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e29 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m29*m30*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
652.0, 923.0
17.0, 17.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
735.0, 863.0
17.0, 17.0

p33

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
756.0, 923.0
17.0, 17.0

p33

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
872.0, 743.0
17.0, 17.0

p33

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 16846591,9822609,9541017,12213596 Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response

Go back
823.0, 738.0
19.0, 19.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e10

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m10*0.1

nodelay

--

true

0

false

PMID: 16846591,14625680 Furthermore, macrophages primed with interferon (IFN)-¦Ã increases the expression of Fc¦ÃR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing

Go back
786.0, 910.0
19.0, 19.0

p37

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e10

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m10*0.1

nodelay

--

true

0

false

PMID: 16846591,14625680 Furthermore, macrophages primed with interferon (IFN)-¦Ã increases the expression of Fc¦ÃR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing

Go back
827.0, 698.0
19.0, 19.0

p37

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e10

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m10*0.1

nodelay

--

true

0

false

PMID: 16846591,14625680 Furthermore, macrophages primed with interferon (IFN)-¦Ã increases the expression of Fc¦ÃR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing

Go back
922.0, 786.0
19.0, 19.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e8

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m8*0.1

nodelay

--

true

0

false

PMID: 16846591,11404376 After IFN stimulation, hundreds of cellular genes known as interferon-stimulated genes (ISGs) are transcriptionally activated

Go back
903.0, 758.0
19.0, 19.0

p37

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e10

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m10*0.1

nodelay

--

true

0

false

PMID: 16846591,14625680 Furthermore, macrophages primed with interferon (IFN)-¦Ã increases the expression of Fc¦ÃR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing

Go back
998.0, 762.0
19.0, 19.0

p41

p41

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

e37

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 16846591,14625680 Furthermore, macrophages primed with interferon (IFN)-¦Ã increases the expression of Fc¦ÃR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing

Go back
783.0, 691.0
17.0, 17.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e7

G010432

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m7*0.1

nodelay

--

true

0

false

PMID: 16846591,12872134 As IFN-¦Â is known to upregulate p53 expression and thereby the apoptotic cellular response, it can be argued that cell death induced by Ad-IRF-3 could be mediated by IFN-alpha/¦Â

Go back
246.0, 625.0
21.0, 21.0

p27

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000041446 MO000000058

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m19314*m36*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun

Go back
402.0, 521.0
21.0, 21.0

p27

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000041446 MO000000062

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m19314*m39*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun

Go back
309.0, 613.0
21.0, 21.0

p27

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e17 MO000000062

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m17*m39*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun

Go back
203.0, 174.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m19828*m41*0.1

nodelay

--

true

0

false

PMID: 16846591,14976261,14976262,12626561 Plasmacytoid dendritic cells (pDC) are major IFN producing cells and stand out amongst other cells in their ability to produce high amounts of IFN-greek small letter alpha/¦Â following engagement of TLR9 by unmethylated DNA or stimulation of hTLR7/mTLR8 by single stranded viral RNA

Go back
199.0, 330.0
19.0, 19.0

p46

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000042127

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m43*m155901*0.1

nodelay

--

true

0

false

PMID: 16846591,14976261,14976262,12626561 Plasmacytoid dendritic cells (pDC) are major IFN producing cells and stand out amongst other cells in their ability to produce high amounts of IFN-greek small letter alpha/¦Â following engagement of TLR9 by unmethylated DNA or stimulation of hTLR7/mTLR8 by single stranded viral RNA

Go back
199.0, 214.0
19.0, 19.0

p46

p48

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000042007

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m43*m19823*0.1

nodelay

--

true

0

false

PMID: 16846591,14976261,14976262,12626561 Plasmacytoid dendritic cells (pDC) are major IFN producing cells and stand out amongst other cells in their ability to produce high amounts of IFN-greek small letter alpha/¦Â following engagement of TLR9 by unmethylated DNA or stimulation of hTLR7/mTLR8 by single stranded viral RNA

Go back
467.0, 214.0
19.0, 19.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e40

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m1572*m42*0.1

nodelay

--

true

0

false

PMID: 16846591,15800576 pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/¦Â induction, which is also dependent on IRF-7

Go back
682.0, 678.0
19.0, 19.0

p4

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e7

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m7*0.1

nodelay

--

true

0

false

PMID: 16846591,11404376 After IFN stimulation, hundreds of cellular genes known as interferon-stimulated genes (ISGs) are transcriptionally activated

Go back
559.0, 510.0
19.0, 19.0

p49

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 MO000016573

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m44*m1572*0.1

nodelay

--

true

0

false

PMID: 16846591,15800576 pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/¦Â induction, which is also dependent on IRF-7

Go back
615.0, 406.0
19.0, 19.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000039077 MO000000212 MO000007702 e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m17258*m183*m980*m46*0.1

nodelay

--

true

0

false

PMID: 16846591,14991609,15492225 Coccia et al. hypothesize that the regulation of IFN-alpha production in pDCs may not be mediated by the positive feedback effect of IFN-¦Â due to constitutive expression of IRF-7 and the ability of MyD88 to recruit IRF-7, but not IRF-3, through a molecular complex including TRAF6 and IRAK4

Go back
510.0, 338.0
19.0, 19.0

p51

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45 MO000007702 MO000000212 MO000039077

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m47*m980*m183*m17258*0.1

nodelay

--

true

0

false

PMID: 16846591,14991609,15492225 Coccia et al. hypothesize that the regulation of IFN-alpha production in pDCs may not be mediated by the positive feedback effect of IFN-¦Â due to constitutive expression of IRF-7 and the ability of MyD88 to recruit IRF-7, but not IRF-3, through a molecular complex including TRAF6 and IRAK4

Go back
496.0, 647.0
17.0, 17.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000210 e46

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m181*m48*0.1

nodelay

--

true

0

false

PMID: 16846591,16612387 In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway

Go back
432.0, 707.0
17.0, 17.0

p53

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000210 e47

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m181*m49*0.1

nodelay

--

true

0

false

PMID: 16846591,16612387 In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway

Go back
203.0, 286.0
19.0, 19.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 16846591,16612387 In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway

Go back
146.0, 198.0
19.0, 19.0

p55

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e49

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 16846591,16612387 In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway

Go back
691.0, 850.0
19.0, 19.0

p57

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e46

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 16846591, 15800576 pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/¦Â induction, which is also dependent on IRF-7

Go back
539.0, 943.0
17.0, 17.0

p58

p58

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e65 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m67*m68*0.1

nodelay

--

true

0

false

PMID: 16846591,11256746,9822609,11585785,9541017,11544356,11846975 The ISGF3 complex (ISGF3¦Ã/IRF-9-STAT1-STAT2) binds to interferon-stimulated response elements (ISRE) found in numerous IFN-induced gene promoters such as PKR, 2¡ì?5¡ì oligoadenylate synthase and IRF-7

Go back
751.0, 694.0
19.0, 19.0

p57

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e46

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 16846591, 15800576 pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/¦Â induction, which is also dependent on IRF-7

Go back
557.0, 569.0
21.0, 21.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16846591 These genes encode proteins such as RNase L, dsRNA-dependent protein kinase (PKR), and 2¡ì?5¡ì oligoadenylate synthetase (OAS), that mediate antiviral activities directly or indirectly.

Go back
642.0, 962.0
19.0, 19.0

p57

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e64

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 16846591, 15800576 pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/¦Â induction, which is also dependent on IRF-7

Go back
790.0, 854.0
19.0, 19.0

p57

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e64

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 16846591, 15800576 pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/¦Â induction, which is also dependent on IRF-7

Go back
727.0, 918.0
19.0, 19.0

p58

p62

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e65 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m67*m70*0.1

nodelay

--

true

0

false

PMID: 16846591,11256746,9822609,11585785,9541017,11544356,11846975 The ISGF3 complex (ISGF3¦Ã/IRF-9-STAT1-STAT2) binds to interferon-stimulated response elements (ISRE) found in numerous IFN-induced gene promoters such as PKR, 2¡ì?5¡ì oligoadenylate synthase and IRF-7

Go back
799.0, 814.0
19.0, 19.0

p58

p63

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e65 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m67*m72*0.1

nodelay

--

true

0

false

PMID: 16846591,11256746,9822609,11585785,9541017,11544356,11846975 The ISGF3 complex (ISGF3¦Ã/IRF-9-STAT1-STAT2) binds to interferon-stimulated response elements (ISRE) found in numerous IFN-induced gene promoters such as PKR, 2¡ì?5¡ì oligoadenylate synthase and IRF-7

Go back
517.0, 669.0
21.0, 21.0

p6

p7

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

e67

MO000008179

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c17 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 16846591 These genes encode proteins such as RNase L, dsRNA-dependent protein kinase (PKR), and 2¡ì?5¡ì oligoadenylate synthetase (OAS), that mediate antiviral activities directly or indirectly.

Go back
586.0, 453.0
21.0, 21.0

p6

p8

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

e69

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c19 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 16846591 These genes encode proteins such as RNase L, dsRNA-dependent protein kinase (PKR), and 2¡ì?5¡ì oligoadenylate synthetase (OAS), that mediate antiviral activities directly or indirectly.

Go back
134.0, 286.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 16846591,11846975 Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-¦ÊB and ATF-2/c-Jun

Go back
637.9932582089723, 42.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0, 143.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
797.0, 708.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
219.0, 518.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
278.0, 613.2362051439704

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.319744306791, 606.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.099660075834, 377.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
259.10918275627523, 653.9227339733947

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 645.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.22213653792284, 377.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
425.95715430863214, 548.2790621242674

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.0, 542.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.9382230137094, 797.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
219.0, 522.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.95669194279526, 609.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.0, 627.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
229.8885676102462, 169.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.0, 171.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 185.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
152.0, 334.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.9368211420091, 353.36229006375015

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.0, 349.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.0, 239.55385536415233

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.0, 147.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
225.9909451017955, 225.3805211953236

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.0, 233.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.0, 183.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.0, 206.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.5894663844041, 227.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.0, 473.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 183.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.6508125684107, 453.33774828479216

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.990651168656, 412.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.6408884783128, 432.12347745756864

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.0, 697.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.0, 199.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.96895633214325, 393.70408449520943

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.0, 254.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 356.79531307599984

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.6311203773992, 199.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.4091746756088, 362.8941351637668

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.5571945406894, 353.62465439137713

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.27518639922204, 287.3274108337527

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.0, 671.2431799555832

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.0, 406.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0058417490118, 596.9248272095319

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.9342162777379, 353.76265466132133

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 731.836821605132

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.0, 294.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
314.42007913242037, 317.6251699648482

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
229.88784708366475, 299.33486642954324

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 302.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
171.9269205859564, 217.00222078299703

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.0, 212.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.0, 404.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.0, 869.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.2436714876709, 563.3954710098458

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.0, 399.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.0, 713.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 318.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.0, 961.3544901775847

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.0, 316.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
756.7747526978919, 873.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 877.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 922.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 947.5689290811055

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
533.1558634193174, 697.7040413366784

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.0, 866.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.1453068013922, 781.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.7075489304051, 847.3599068047633

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 482.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.0, 746.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.0, 825.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.3866444113866, 614.990651168656

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0, 826.1149377533789

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.7756701923552, 467.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.1698434185678, 76.54871037888707

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.21645747403153, 247.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.9269205859564, 213.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.0, 298.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
137.0, 465.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 448.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.0, 456.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
219.0, 515.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
309.0, 573.5894663844041

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.0, 566.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.76972249084247, 377.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.0, 78.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.1488114572491, 541.9986158271411

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 534.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.0, 699.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.48640917197673, 758.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
331.0, 725.9322321511188

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 726.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.0, 1023.1676940130167

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.0, 997.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 993.8074497210199

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
807.0, 872.948485871477

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
841.0, 36.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 865.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.0, 993.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.1877316447983, 969.0899458438937

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.4204706649821, 1005.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.0, 1060.019375177176

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.9514823047726, 629.7583320897058

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0967135508015, 52.72034923341461

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.0, 736.5786597586991

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.0, 391.33907124632003

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 133.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.0, 64.27851937152828

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.0, 329.99723135482276

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.0, 312.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 136.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 196.38052119532358

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 204.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.0, 264.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.1554175279994, 424.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 460.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.3056251348906, 227.26003702255875

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 201.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 66.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.7287725563094, 222.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 333.1570394041598

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.0, 199.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.0, 321.6643638388299

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.0, 323.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 349.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.9656235549245, 331.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 451.61222972731565

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 445.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.9425724154552, 508.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.5508668509281, 36.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 653.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.8570997301327, 540.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 661.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
662.0, 713.5298221281347

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
711.6428191582556, 722.5149236575522

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.2267985930149, 716.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 733.7882251601028

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.3451488442252, 747.2670474891787

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 740.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 804.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
285.0, 77.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 940.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.0, 880.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
741.0, 791.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.0, 804.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.0, 933.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.0, 755.7666052207824

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
883.0, 760.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.6568542494924, 266.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
564.7354436625493, 246.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
481.0, 128.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
294.0, 63.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0, 757.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.0, 130.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
805.0, 927.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.0, 127.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
843.0, 717.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.0, 126.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
867.5777087639997, 777.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 783.6052434640034

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1017.0, 772.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.0, 147.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back