1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16885502.csml convertedTime:2009.07.01.10:56

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Cellular reprogramming by gram-positive bacterial components: a review.
Authors Buckley JM, Wang JH, Redmond HP.
Affiliation Department of Academic Surgery, Cork University Hospital, National University ofIreland/University College Cork, Wilton, Cork, Ireland.
Abstract LPS tolerance has been the focus of extensive scientific and clinical researchover the last several decades in an attempt to elucidate the sequence of changesthat occur at a molecular level in tolerized cells. Tolerance to components ofgram-positive bacterial cell walls such as bacterial lipoprotein andlipoteichoic acid is a much lesser studied, although equally important,phenomenon. This review will focus on cellular reprogramming by gram-positivebacterial components and examines the alterations in cell surface receptorexpression, changes in intracellular signaling, gene expression and cytokineproduction, and the phenomenon of cross-tolerance.
PMID 16885502
Model Abstract

Entity

G010329:TNF-alpha G011134:IRAK1 MO000000022:p38 MO000000023:JNK MO000000058:NF-kappaB MO000000212:TRAF6 MO000000213:IRAK MO000000248:IKK MO000000276:AP-1 MO000000289:TNF-alpha MO000004670:ERK1 MO000004676:ERK2 MO000016566:IRAK-2 MO000016569:IRAK-M MO000016573:MyD88 MO000016574:TAK1 MO000016882:LPS MO000018132:CD14 MO000019394:TLR4 MO000019397:TLR2 MO000022124:TAB MO000039077:IRAK-4 e1: e10: e11:LPS:CD14 e12:BLP e13:BLP:CD14 e14:LTA e15:LTA:CD14 e16:LPS:TLR4 e17:LPS:TLR4:MYD88 e18:LPS:TLR4:MYD88:IRAK e19:LPS:TLR4:MYD88:IRAK:TRAF6 e2: e20:IKK{p} e21:NF-kappaB:IkappaB e22:JNK{p} e23:p38{p} e24:ERK1{p} e25:ERK2{p} e26:AP-1{active} e27:LAM e28:TLR2:LAM e29:STF e3: e30:STF:TLR2 e31:IRAK1 e32:LPS:TLR4:MYD88:IRAK1:TRAF6 e33:IRAK2:TRAF6 e34:IRAK4:TRAF6 e35:IRAKM:TRAF6 e36:IRAK1:TRAF6 e37:protein remnants e38:LPS:TLR4:MYD88:IRAK1 e39:LPS:TLR4:MYD88:IRAK1{p}:TRAF6 e4: e40:LPS:TLR4:MYD88 e41:IRAK1:TRAF6:TAK1:TAB2 e42:NF-kappaB:IkappaB{p} e43:NF-kappaB:IkappaB{p}{ub} e44:NF-kappaB e5:MALP2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR2:MALP2 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p4 p5 p6 p7 p8 p9
Model Detail
749.0, 1086.0
42.0, 42.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p2

p3

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
528.0, 1051.0
38.0, 38.0

IRAK1

--

G011134

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m94019

10

false

infinite

0

unit false false false
TRANSFACG011134

--

Go back
759.0, 336.0
30.0, 30.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p37

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
659.0, 351.0
33.0, 33.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p38

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
246.0, 1110.0
36.0, 36.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p31

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
307.0, 307.0
34.0, 34.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p24 p25 p26 p27

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
432.0, 293.0
36.0, 36.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
236.0, 396.0
32.0, 32.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
552.0, 645.0
36.0, 36.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p19 p20 p21

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1229.0, 1086.0
42.0, 42.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
321.0, 421.0
38.0, 38.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p36

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
855.0, 387.0
34.0, 34.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p35

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
367.0, 575.0
34.0, 34.0

IRAK-2

--

MO000016566

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m1569

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
559.0, 348.0
30.0, 30.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p27 p11 p32

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
523.0, 296.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
209.0, 949.0
38.0, 38.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
852.0, 89.0
36.0, 36.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
850.0, 239.0
40.0, 40.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p4 p5 p6

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
655.0, 240.0
38.0, 38.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1101.0, 362.0
42.0, 42.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p22 p23

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
269.0, 933.0
38.0, 38.0

TAB

--

MO000022124

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m6432

10

false

infinite

0

unit false false false
TRANSPATHMO000022124

--

Go back
409.0, 457.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p29

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
118.21149807766668, 229.77775956587433
1039.797933098786, 1241.5078425114518

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
168.2298787643224, 244.75363206532518
1007.8826108346007, 1165.8727450836984

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
762.5, 225.0
31.0, 60.0

LPS:CD14

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
991.0, 108.3189806678383
46.432337434094904, 30.181019332161686

BLP

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
938.5, 233.0
31.0, 60.0

BLP:CD14

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p30 p35 p36 p37 p38

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1096.0, 118.0
60.0, 34.0

LTA

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1024.5, 239.9592194694146
27.921069940802454, 54.0407805305854

LTA:CD14

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
574.5, 225.0
31.0, 60.0

LPS:TLR4

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
475.5, 233.35951550743255
36.29234721967333, 50.64048449256745

LPS:TLR4:MYD88

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9 p11

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
362.0, 230.0
36.0, 60.0

LPS:TLR4:MYD88:IRAK

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p9

p10

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
144.0, 333.0
36.0, 60.0

LPS:TLR4:MYD88:IRAK:TRAF6

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
118.21149807766668, 229.77775956587433
1039.797933098786, 1241.5078425114518

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
288.0, 532.0
32.0, 32.0

IKK{p}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

p13

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
237.5, 598.5959006832195
28.91334777537077, 35.40409931678054

NF-kappaB:IkappaB

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
659.0, 511.0
33.0, 33.0

JNK{p}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p38

p19

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
759.0, 516.0
30.0, 30.0

p38{p}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p37

p20

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
461.0, 625.0
38.0, 38.0

ERK1{p}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p36

p18

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
855.0, 571.0
34.0, 34.0

ERK2{p}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p35

p21

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
552.0, 801.0
36.0, 36.0

AP-1{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18 p19 p20 p21

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1348.0, 514.0
60.0, 34.0

LAM

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p22

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1098.5, 573.0
31.0, 60.0

TLR2:LAM

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1342.0, 611.62
39.84, 29.880000000000003

STF

--

e29

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p23

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
139.00745673964238, 246.8784185536354
998.2060157748347, 1207.3065245359305

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1102.5, 693.0
31.0, 60.0

STF:TLR2

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
387.0, 308.46000000000004
38.72, 29.04

IRAK1

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p30

p11

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
130.0, 458.0
36.0, 60.0

LPS:TLR4:MYD88:IRAK1:TRAF6

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p29

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
462.5, 726.6570571571405
34.580069988335275, 42.34294284285953

IRAK2:TRAF6

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
457.5, 546.0568238626895
33.43692717880353, 40.94317613731044

IRAK4:TRAF6

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
558.5, 540.7062156307283
30.456590568238624, 37.293784369271776

IRAKM:TRAF6

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
212.0, 738.5248618784531
31.027624309392277, 34.47513812154696

IRAK1:TRAF6

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p28

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
224.0, 1040.2889144170015
40.045950603101666, 38.71108558299829

protein remnants

--

e37

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
198.0, 226.0
36.0, 60.0

LPS:TLR4:MYD88:IRAK1

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p24

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
138.0, 570.0
36.0, 60.0

LPS:TLR4:MYD88:IRAK1{p}:TRAF6

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p32

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
177.4799802642976, 276.80457178221707
921.2609687255247, 1147.4542180787662

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
138.5, 702.0
43.0, 60.0

LPS:TLR4:MYD88

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
302.0, 810.0
36.0, 60.0

IRAK1:TRAF6:TAK1:TAB2

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p12 p14 p15 p17 p16

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
310.5, 663.0954840859857
26.872021329778367, 32.90451591401434

NF-kappaB:IkappaB{p}

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p33

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
347.5, 895.8968505249126
33.56757207132144, 41.103149475087484

NF-kappaB:IkappaB{p}{ub}

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
406.0, 1206.0
36.0, 36.0

NF-kappaB

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1296.0, 368.7355008787346
44.25307557117751, 28.764499121265377

MALP2

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
341.3122858905574, 944.7538366094936
565.461779126626, 421.68857236811147

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
402.38637004203645, 954.74724273586
330.64245557869754, 408.7002179830567

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
348.68329604677047, 950.382123509684
550.7197588142002, 410.43199856773055

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
349.7362974976579, 951.248013802021
548.6137559124247, 408.7002179830567

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
341.3122858905574, 944.7538366094936
565.461779126626, 421.68857236811147

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
341.3122858905574, 944.7538366094936
565.461779126626, 421.68857236811147

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
349.7362974976579, 951.248013802021
548.6137559124247, 408.7002179830567

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
754.0888546384851, 1117.9318950768904
35.32694502778256, 26.297522151668414

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
661.4247269603791, 1239.1565360040684
100.03513783431926, 74.46656514098072

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
341.3122858905574, 944.7538366094936
565.461779126626, 421.68857236811147

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1106.5, 453.0
31.0, 60.0

TLR2:MALP2

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2 p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
474.5884455962687, 1132.1487537285236
17.907343686132435, 7.089974254487487

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
473.9904687023914, 1111.0047727381946
61.29263162241806, 90.72243006315605

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
499.7034751391137, 1170.0112313158575
9.56763030203598, 7.867527810354993

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
131.87292628674265, 234.77368526931033
1019.7178247061664, 1188.1625113094392

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
135.51597380916292, 255.74360546333259
978.227459964067, 1167.993342404602

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
145.2307672022836, 276.71352565735486
973.7613150179247, 1152.6754023916155

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1207.0, 371.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3964*m5*0.1

nodelay

--

true

0

false

PMID: 16885502 MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.

Go back
314.0, 167.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000000212 MO000016569

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c89 : 1
stoichiometry:c30 : 1

m18*m183*0.1

nodelay

--

true

0

false

PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6). PMID: 16885502 IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.

Go back
224.0, 168.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e31 e17 MO000016569

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c108 : 1
stoichiometry:c92 : 1

m34*m17*0.1

nodelay

--

true

0

false

PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6). PMID: 16885502 IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.

Go back
244.0, 476.0
23.0, 23.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000248 e41

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c36 : 1
stoichiometry:c32 : 1

m207*m44*0.1

nodelay

--

true

0

false

PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B

Go back
313.0, 605.0
21.0, 21.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e21 e20

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c35 : 1
stoichiometry:c34 : 1

m21*m20*0.1

nodelay

--

true

0

false

PMID: 16885502, 10602462 Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.

Go back
664.0, 444.0
23.0, 23.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000023 e41

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m23*m44*0.1

nodelay

--

true

0

false

PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.

Go back
764.0, 436.0
23.0, 23.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e41

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c103 : 1
stoichiometry:c41 : 1

m25*m44*0.1

nodelay

--

true

0

false

PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.

Go back
336.0, 504.0
23.0, 23.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004670 e41

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c105 : 1
stoichiometry:c44 : 1

m549*m44*0.1

nodelay

--

true

0

false

PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.

Go back
858.0, 482.0
27.0, 27.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004676 e41

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c104 : 1
stoichiometry:c46 : 1

m554*m44*0.1

nodelay

--

true

0

false

PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.

Go back
557.0, 726.0
25.0, 25.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m219*m27*0.1

nodelay

--

true

0

false

PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.

Go back
614.0, 727.0
23.0, 23.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e22

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m219*m24*0.1

nodelay

--

true

0

false

PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.

Go back
756.0, 989.0
27.0, 27.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e6

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c4 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 16885502 MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.

Go back
500.0, 733.0
19.0, 19.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m219*m26*0.1

nodelay

--

true

0

false

PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.

Go back
664.0, 725.0
19.0, 19.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m219*m28*0.1

nodelay

--

true

0

false

PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.

Go back
1250.0, 519.0
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m3964*m30*0.1

nodelay

--

true

0

false

PMID: 16885502 The mycobacterial components, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), activated cells expressing TLR2.

Go back
1213.0, 614.0
25.0, 25.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m3964*m32*0.1

nodelay

--

true

0

false

PMID: 16885502 The mycobacterial components, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), activated cells expressing TLR2.

Go back
224.0, 315.5
16.5, 16.5

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e38

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m183*m41*0.1

nodelay

--

true

0

false

PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.

Go back
430.0, 670.0
27.0, 27.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016566 MO000000212

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m1569*m183*0.1

nodelay

--

true

0

false

PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.

Go back
461.0, 446.0
25.0, 25.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000039077

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m183*m17258*0.1

nodelay

--

true

0

false

PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.

Go back
499.0, 352.0
21.0, 21.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016569 MO000000212

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m1571*m183*0.1

nodelay

--

true

0

false

PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.

Go back
216.0, 828.0
23.0, 23.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000016574 MO000022124

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m39*m1573*m6432*0.1

nodelay

--

true

0

false

PMID: 16885502, 14751757 Following phosphorylation of IRAK-1, IRAK-1 and TRAF-6 dissociate from the receptor complex, and TRAF-6 interacts with TGF-?-activated kinase-1 (TAK-1), TAK-1/2-binding protein, resulting in activation of TAK-1.

Go back
292.0, 460.0
23.0, 23.0

p29

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000039077 e32

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c93 : 1
stoichiometry:c82 : 1

m17258*m35*0.1

nodelay

--

true

0

false

PMID: 16885502, 12055225 LPS causes IRAK-1 activation, phosphorylation, and subsequent degradation. PMID: 16885502, 11960013 IRAK-4 has been demonstrated to act upstream of IRAK-1 and is responsible for phosphorylation of IRAK-1.

Go back
973.0, 1094.0
25.0, 25.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e6

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c6 : 1

m93309*m6*0.1

nodelay

--

true

0

false

PMID: 16885502 MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.

Go back
395.0, 859.5
22.5, 22.5

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011134 e13

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m94019*0.1

nodelay

--

true

0

false

PMID: 16885502 When cells were pretreated with BLP for 24 h, there was a marked decrease in IRAK-1 protein levels compared with na?ve cells.

Go back
254.0, 1210.0
27.0, 27.0

p31

p31

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000058

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 16885502 Following activation, NF-{kappa}B is translocated to the nucleus, where it activates the transcription of proinflammatory genes.

Go back
197.0, 657.0
30.0, 30.0

p32

p32

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e39 MO000016569

e36 e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c109 : 1
stoichiometry:c85 : 1
stoichiometry:c94 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 16885502, 14751757 Following phosphorylation of IRAK-1, IRAK-1 and TRAF-6 dissociate from the receptor complex, and TRAF-6 interacts with TGF-?-activated kinase-1 (TAK-1), TAK-1/2-binding protein, resulting in activation of TAK-1. PMID: 16885502 IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.

Go back
352.0, 752.0
23.0, 23.0

p33

p33

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 16885502, 10602462 Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.

Go back
333.0, 985.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e43

e37 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 16885502, 10602462 Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.

Go back
912.0, 484.0
23.0, 23.0

p35

p35

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004676 e13

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m554*m13*0.1

nodelay

--

true

0

false

PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.

Go back
420.0, 536.0
23.0, 23.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004670 e13

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c114 : 1

m549*m13*0.1

nodelay

--

true

0

false

PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.

Go back
801.0, 453.0
21.0, 21.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e13

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1

m25*m13*0.1

nodelay

--

true

0

false

PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.

Go back
702.0, 446.0
27.0, 27.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000023 e13

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c121 : 1
stoichiometry:c120 : 1

m23*m13*0.1

nodelay

--

true

0

false

PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.

Go back
857.0, 174.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018132 MO000016882

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m2828*m155666*0.1

nodelay

--

true

0

false

PMID: 16885502, 1698311 CD14 recognizes and binds LPS with high-affinity.

Go back
942.0, 167.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018132 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m2828*m12*0.1

nodelay

--

true

0

false

PMID: 16885502, 9605151, 10452971, 8675286 CD14 has also been implicated in activation of the inflammatory response to gram-positive bacterial components such as BLP and LTA.

Go back
1021.0, 178.0
26.0, 26.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 MO000018132

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m14*m2828*0.1

nodelay

--

true

0

false

PMID: 16885502, 9605151, 10452971, 8675286 CD14 has also been implicated in activation of the inflammatory response to gram-positive bacterial components such as BLP and LTA.

Go back
713.0, 162.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 MO000019394

e16 MO000018132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m11*m3961*0.1

nodelay

--

true

0

false

PMID: 16885502, 11067937, 10725698 Multiple studies have confirmed that LPS signals primarily through TLR4.

Go back
527.0, 160.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000016573

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m16*m1572*0.1

nodelay

--

true

0

false

PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).

Go back
438.0, 151.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000000213

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m17*m184*0.1

nodelay

--

true

0

false

PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).

Go back
1143.0, 383.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.0, 125.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.0, 775.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.94028500029066, 937.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
338.0, 463.22154656919963

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
338.0, 509.23059786718113

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
323.0, 534.971386254742

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.0, 1146.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 1224.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.5171678661471, 187.905132594163

c108

c108

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
230.04413457202486, 376.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
800.4121929822057, 197.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.0, 421.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.9220899170605, 507.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.9973925040905, 293.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.0, 459.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.0, 559.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0204582183614, 271.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 366.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.9691115068547, 474.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.6241387262427, 285.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.0, 384.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.0, 195.54486973001428

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0082901643336, 473.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.1745930576234, 276.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
970.8362976331207, 139.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0, 190.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.8361755317706, 152.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.0, 191.0115619255174

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.0, 204.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.4025068970706, 193.6796656369347

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 193.79117527163274

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1238.0, 383.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.893816894603, 183.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 182.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.2771337008357, 187.76063068841773

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 189.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.5777087639997, 181.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.3289916300825, 181.2744631916617

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.0, 182.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.68004009839757, 174.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.47313334622226, 196.6325770306054

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 197.99883143440803

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1143.5369606578715, 394.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
185.31491071063937, 190.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.0, 428.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.0, 499.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.0, 616.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 626.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
309.0, 564.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
259.44221496150834, 506.86892724612454

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 384.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 467.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
338.0, 472.8682486124556

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
770.0, 1016.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
774.0, 366.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
774.2805291210643, 459.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 459.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0, 527.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 421.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 509.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 681.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.4943566124291, 506.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
570.0, 751.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.0, 663.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
583.0, 681.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.5267399752993, 750.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.8299425662265, 544.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.8, 681.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 752.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.2342591372069, 543.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.0, 675.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.2389335532322, 743.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.0, 1107.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.4357412084983, 601.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1142.0, 404.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1281.0, 531.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1137.2027916227355, 537.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1131.0, 404.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1246.0, 627.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1139.9876304892857, 639.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.0, 324.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 286.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
166.66770596713263, 332.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.0, 1107.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
395.0, 609.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.0, 341.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 697.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.0, 339.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
439.0, 464.10493924633687

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 471.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 363.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
341.0, 328.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 373.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.6316319605415, 888.5228816777626

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.6955262817094, 513.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
406.0, 346.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.6786874235581, 280.0

c81

c81

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
180.0522769188681, 482.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 623.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.0, 687.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.7452636311995, 1003.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.1449554967866, 1006.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.0, 472.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.21038193527386, 189.3860946816225

c89

c89

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
870.0, 207.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.13158931050404, 194.13844456302803

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.65055317494995, 185.33859704037772

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.99232831848494, 191.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
166.0, 473.821038417048

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.1811873607643, 687.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
228.0, 773.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 859.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.7825416385168, 858.0492821445085

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
239.0, 840.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 696.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back