1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16920490.csml convertedTime:2009.07.01.10:56

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signal integration between IFNgamma and TLR signalling pathways in macrophages.
Authors Schroder K, Sweet MJ, Hume DA.
Affiliation Institute for Molecular Bioscience, University of Queensland, QLD BiosciencePrecinct, Brisbane, QLD 4072, Australia. K.Schroder@imb.uq.edu.au
Abstract Macrophages are major effector cells of the innate immune system, andappropriate regulation of macrophage function requires the integration ofmultiple signalling inputs derived from the recognition of host factors (e.g.interferon-gamma/IFNgamma) and pathogen products (e.g. toll-like receptor/TLRagonists). The profound effects of IFNgamma pre-treatment ("priming") onTLR-induced macrophage activation have long been recognised, but many of themechanisms underlying the priming phenotype have only recently been identified.This review summarises the known mechanisms of integration between the IFNgammaand TLR signalling pathways. Synergy occurs at multiple levels, ranging fromsignal recognition to convergence of signals at the promoters of target genes.In particular, the cross-talk between the IFNgamma, and LPS and CpG DNAsignalling pathways is discussed.
PMID 16920490
Model Abstract

Entity

e1: e10: e11:IFN-gamma: IFN-gamma receptor e12:Tlr2 e13:Tlr4 e14:Tlr6 e15:TLR2 e16:TLR4 e17:LPS e18:CD14 e19:CD14:LPS e2: e20:TLR4 e21:ST2L e22:TLR4:MD-2 e23:TLR4:MD-2:CD14:LPS e24:MyD88 e25:TLR4:MD-2:CD14:LPS:MyD88 e26:TRAM e27:TLR4:MD-2:CD14:LPS:TRAM e28:TRIF e29:TLR4:MD-2:CD14:TRIF e3: e30:CpG DNA e31:TLR9 e32:TLR9:CpGDNA e33:MyD88:TLR9:CpGDNA e34:IRAK-M e35:SOCS1 e36:TLR2 e37:Tlr9 e39:CSF-1 e4: e40:MD-2 e41:MD-2 e42:CD14 e43:myd88 e44:IRAK1 e45:socs3 e46:ST2L e47:NF-KappB:IKBalpha e48:NFKappaB{active} e49:NFKappB{active} e5:IFN-gamma e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFN-gamma receptor e60: e61: e62: e63:DNA:NFKappaB e64:DNA e66:AP-1 e67:STAT1 e68:STAT1{p} e69:Inos e7: e70:ifnbeta e71:Lipotechoi acid e72:TLR2:Lipotechoic acid e73:p38 MAPK e74:p38 MAPK{active} e75:STAT1{p} e77:DNA:STAT1 e78:STAT1{ace} e8: e80:Hdac1 e81:STAT1{ace}:HDAC1 e82:HDAC1 e83:cox2 e84:Icsbp e85:ICSBP e86:TRAF6 e87:ICSBP:TRAF6 e88:PU.1 e89:PU.1{p} e9: e90:PU.1{p}:ICSBP

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p7 p8 p9
Model Detail
57.75, 58.99690800911758
1037.796572974681, 1481.2686239592344

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
67.7490977212101, 81.63741303309467
1005.942680004875, 1391.0268285766197

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1048.5, 102.0
31.0, 60.0

IFN-gamma: IFN-gamma receptor

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
634.0, 380.0
60.0, 32.0

Tlr2

--

e12

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p2

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
546.0, 508.0
60.0, 32.0

Tlr4

--

e13

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
538.0, 576.0
60.0, 32.0

Tlr6

--

e14

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
581.0, 261.5
38.719999999999985, 29.039999999999992

TLR2

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
540.5, 183.0
30.74522036627089, 49.8571141074663

TLR4

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1147.0, 230.0
50.588730025231285, 28.666947014297733

LPS

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1046.5, 197.0
34.68189806678383, 53.35676625659052

CD14

--

e18

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1048.5, 274.0
31.0, 60.0

CD14:LPS

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
57.75, 58.99690800911758
1037.796572974681, 1481.2686239592344

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1045.5, 348.0
36.304042179261856, 55.852372583479784

TLR4

--

e20

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
911.0, 995.5
41.10283759307708, 25.346749849064203

ST2L

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1044.5, 642.0
31.0, 60.0

TLR4:MD-2

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1041.0, 723.2352941176471
38.735294117647065, 64.55882352941177

TLR4:MD-2:CD14:LPS

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
971.0, 660.5
41.279999999999994, 30.960000000000008

MyD88

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1042.0, 798.0
36.0, 60.0

TLR4:MD-2:CD14:LPS:MyD88

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
973.5, 820.0
29.099617629301676, 47.1885691285973

TRAM

--

e26

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1042.0, 882.0
36.0, 60.0

TLR4:MD-2:CD14:LPS:TRAM

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
968.0, 905.0
23.130028063610848, 53.37698783910196

TRIF

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1046.0, 978.0
36.0, 60.0

TLR4:MD-2:CD14:TRIF

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
78.5059314594936, 79.40005709946523
996.2847100556938, 1440.4623257785406

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1170.0, 941.5
60.0, 13.0

CpG DNA

--

e30

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1046.5, 1050.0
34.110720562390156, 52.478031634446396

TLR9

--

e31

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1048.5, 1138.0
31.0, 60.0

TLR9:CpGDNA

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1042.5, 1226.0
43.0, 60.0

MyD88:TLR9:CpGDNA

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
542.0, 644.0
60.0, 32.0

IRAK-M

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
562.0, 716.0
60.0, 32.0

SOCS1

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18 p29

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1046.5, 565.0
35.481546572934974, 54.58699472759226

TLR2

--

e36

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
538.0, 392.0
60.0, 32.0

Tlr9

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1047.5, 422.0
32.085530287784266, 52.030589655866365

CSF-1

--

e39

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p19 p53 p54

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
116.90440465955692, 115.10556800757345
919.4877636555676, 1369.051303962323

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
770.0, 616.0
60.0, 32.0

MD-2

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
932.0, 457.5
39.67999999999999, 29.76000000000001

MD-2

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
570.0, 776.0
60.0, 32.0

CD14

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p23

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
450.0, 484.0
60.0, 32.0

myd88

--

e43

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
346.0, 576.0
60.0, 32.0

IRAK1

--

e44

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
534.0, 872.0
60.0, 32.0

socs3

--

e45

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p27 p28

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
414.0, 736.0
60.0, 32.0

ST2L

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
682.0, 116.0
36.397790055248606, 40.44198895027625

NF-KappB:IKBalpha

--

e47

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p35 p59

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
495.0, 122.5
42.27409941638157, 26.069027973435297

NFKappaB{active}

--

e48

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
411.0, 364.5
50.15898571141074, 30.931374522036627

NFKappB{active}

--

e49

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1135.0, 19.5
41.91185349164821, 25.8456429865164

IFN-gamma

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
131.2215946810789, 312.4166528503613
831.7327807350462, 754.2902499403506

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
221.05493040292737, 330.29223520840645
486.33909339069703, 731.0574907019416

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
142.06354899233648, 322.4841818536727
810.0488721125315, 734.15519193373

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
143.61239960823042, 324.03303246956614
806.9511708807424, 731.0574907019416

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
131.2215946810789, 312.4166528503613
831.7327807350462, 754.2902499403506

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
131.2215946810789, 312.4166528503613
831.7327807350462, 754.2902499403506

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
140.21656398398017, 325.7309502816913
806.9511708807424, 731.0574907019416

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
738.3710361115063, 622.1867760291495
51.96209418117354, 47.03936946927301

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
602.072181912836, 839.0258622543043
147.14080850992443, 133.20115296687925

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
131.2215946810789, 312.4166528503613
831.7327807350462, 754.2902499403506

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
947.5, 42.0
33.6994727592267, 51.845342706502635

IFN-gamma receptor

--

e6

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
327.2563312620928, 647.6170071722071
26.339755062932042, 12.682104289559895

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
326.3767722837159, 609.7959711019987
90.15479528363787, 162.27863151054828

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
364.19780835392567, 715.3430485072331
14.072943654031258, 14.072943654031274

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
250.0, 547.5
60.0, 17.0

DNA:NFKappaB

--

e63

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p34 p41

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
322.0, 521.5
60.0, 13.0

DNA

--

e64

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p34 p47 p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
538.0, 932.0
60.0, 32.0

AP-1

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p36

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
123.0, 222.5
42.16542563896156, 26.002012477359628

STAT1

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37 p42 p48

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
271.0, 328.0
49.7560975609756, 39.80487804878048

STAT1{p}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
350.0, 632.0
60.0, 32.0

Inos

--

e69

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
71.38513325619559, 64.95765005095696
1017.7551139455053, 1417.621208583745

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
170.0, 688.0
60.0, 32.0

ifnbeta

--

e70

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p39

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1182.0, 363.0
60.0, 34.0

Lipotechoi acid

--

e71

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p31

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1048.5, 486.0
31.0, 60.0

TLR2:Lipotechoic acid

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
163.5, 1001.0
33.634332863755276, 54.542161400684236

p38 MAPK

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p43 p44 p45

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
325.5, 1078.0
37.0, 60.0

p38 MAPK{active}

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
275.0, 592.0
44.8780487804878, 35.90243902439024

STAT1{p}

--

e75

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
402.0, 815.5
60.0, 17.0

DNA:STAT1

--

e77

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
217.0, 262.5
37.12, 27.840000000000003

STAT1{ace}

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p51

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
75.02116879118105, 89.97729452416354
976.3446081441546, 1393.556956996229

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
346.0, 868.0
60.0, 32.0

Hdac1

--

e80

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
803.5, 1103.0
40.08348608565238, 49.08181969671721

STAT1{ace}:HDAC1

--

e81

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p51

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
591.0, 1136.5
50.9559267458241, 31.422821493258194

HDAC1

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
550.0, 992.0
60.0, 32.0

cox2

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p52

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
762.0, 676.0
60.0, 32.0

Icsbp

--

e84

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
863.0, 1173.5
50.56, 37.92000000000001

ICSBP

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
639.0, 1266.5
57.21070637955323, 35.27993560072449

TRAF6

--

e86

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p56

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
799.5, 1382.0
49.0, 60.0

ICSBP:TRAF6

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
362.0, 1229.5
60.0, 37.0

PU.1

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p57

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
482.0, 1300.0
60.0, 48.0

PU.1{p}

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
84.71726355114242, 114.99693899737011
971.8870594493789, 1375.2808066990015

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
375.5, 1366.0
49.0, 60.0

PU.1{p}:ICSBP

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1141.0, 85.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 16920490 IFN-gamma binds to the IFN-gamma receptor.

Go back
1189.0, 549.0
29.0, 29.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c76 : 1
stoichiometry:c23 : 1

m20*m41*0.1

nodelay

--

true

0

false

PMID: 16920490, 1698311, 10359581 In the case of LPS, efficient ligand recognition requires the signalling receptor TLR4, as well as the CD14 co-receptor (Wright et al., 1990) and MD-2 accessory molecule

Go back
1185.0, 441.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m19*m22*0.1

nodelay

--

true

0

false

PMID: 16920490, 1698311, 10359581 n the case of LPS, efficient ligand recognition requires the signalling receptor TLR4, as well as the CD14 co-receptor (Wright et al., 1990) and MD-2 accessory molecule

Go back
1158.0, 746.0
27.0, 27.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m24*m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 14993454 Full signal transduction requires a number of signalling adaptors, including MyD88 and the adaptors of the MyD88-independent pathway, TRAM (also called TIRP, TICAM2) and TRIF (also known as TICAM1) (reviewed in Vogel et al., 2003)

Go back
1154.0, 694.0
27.0, 27.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m23*m26*0.1

nodelay

--

true

0

false

PMID: 16920490, 14993454 Full signal transduction requires a number of signalling adaptors, including MyD88 and the adaptors of the MyD88-independent pathway, TRAM (also called TIRP, TICAM2) and TRIF (also known as TICAM1) (reviewed in Vogel et al., 2003)

Go back
1149.0, 825.0
30.0, 30.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m23*m28*0.1

nodelay

--

true

0

false

PMID: 16920490, 14993454 Full signal transduction requires a number of signalling adaptors, including MyD88 and the adaptors of the MyD88-independent pathway, TRAM (also called TIRP, TICAM2) and TRIF (also known as TICAM1) (reviewed in Vogel et al., 2003)

Go back
1187.0, 1011.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m31*m30*0.1

nodelay

--

true

0

false

PMID: 16920490, 11130078 CpG DNA signalling is mediated by the TLR9 signalling receptor

Go back
1170.0, 1158.0
27.0, 27.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cell

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m24*m32*0.1

nodelay

--

true

0

false

PMID: 16920490, 11130078 CpG DNA signalling is mediated by the TLR9 signalling receptor (Hemmi et al., 2000), and unlike TLR4, the MyD88 signalling adaptor mediates all known downstream responses (Schnare et al., 2000).

Go back
678.5, 680.0
30.5, 30.5

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 15928677 LPS induces expression of negative regulators of key adaptor/signalling molecules (e.g. IRAK-M and SOCS1 that target IRAKs, ST2L that sequesters MyD88 and MAL) (Liew et al., 2005).

Go back
681.5, 722.0
28.5, 28.5

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 15928677, 11870615, 12811837, 10453004 LPS induces expression of negative regulators of key adaptor/signalling molecules (e.g. IRAK-M and SOCS1 that target IRAKs, ST2L that sequesters MyD88 and MAL) (Liew et al., 2005). Both LPS and IFN¦Ã induced expression of these SOCS proteins (SOCS1 and SOCS3), and LPS pre-treatment inhibited some functions of IFN¦Ã signalling via the activities of these proteins (Crespo et al., 2002; Dalpke et al., 2003; Stoiber et al., 1999

Go back
609.0, 445.0
30.0, 30.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c53 : 1
stoichiometry:c50 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490 Induction of Tlr9 mRNA by IFN¦Ã in BMM was largely dependent on the presence of CSF-1 that suppressed Tlr9 expression (manuscript in preparation).

Go back
684.0, 500.0
32.0, 32.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c7 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 11964313, 12811837,7999637, 11672593, 12831455 IFN¦Ã stimulation induced Tlr2, Tlr4, and Tlr6 mRNAs, upregulated expression of TLR2 and TLR4 protein at the cell surface, and increased resulting LPS-binding ability of macrophages

Go back
977.0, 357.0
30.0, 30.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 16920490 Induction of Tlr9 mRNA by IFN¦Ã in BMM was largely dependent on the presence of CSF-1 that suppressed Tlr9 expression (manuscript in preparation).

Go back
325.0, 213.0
30.0, 30.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 16920490, 10725699 LPS downregulates surface expression of the signalling receptor TLR4, and its accessory molecule, MD-2 (Nomura et al., 2000).

Go back
949.0, 549.0
30.0, 30.0

p22

p22

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 16920490, 10725699 LPS downregulates surface expression of the signalling receptor TLR4, and its accessory molecule, MD-2 (Nomura et al., 2000).

Go back
681.0, 797.0
29.0, 29.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 11964313, 15324355, 12761135,12831455 Numerous reports document the IFN¦Ã-dependent induction of the CD14 co-receptor and MD-2 accessory molecule, which aid in LPS signalling

Go back
785.0, 517.0
30.0, 30.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 12831455, 12761135, 15324355 ,11964313 Numerous reports document the IFN¦Ã-dependent induction of the CD14 co-receptor and MD-2 accessory molecule, which aid in LPS signalling

Go back
421.0, 417.0
30.0, 30.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 11964313, 15324355, 12761135, 12831455 12032143 Additionally, IFN¦Ã upregulated the expression of MyD88 (Bosisio et al., 2002; Mochizuki et al., 2004; Tamai et al., 2003) and IRAK1 (Adib-Conquy and Cavaillon, 2002), which participate in TLR signalling pathways.

Go back
453.0, 533.0
30.0, 30.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490,12032143 Additionally, IFN¦Ã upregulated the expression of MyD88 and IRAK1

Go back
657.0, 853.0
30.0, 30.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 12811837, 10453004, 11870615 Both LPS and IFN¦Ã induced expression of these SOCS proteins (SOCS1 and SOCS3), and LPS pre-treatment inhibited some functions of IFN¦Ã signalling via the activities of these proteins (Crespo et al., 2002; Dalpke et al., 2003; Stoiber et al., 1999).

Go back
437.0, 597.0
30.0, 30.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 11870615, 10453004, 12811837 Both LPS and IFN¦Ã induced expression of these SOCS proteins (SOCS1 and SOCS3), and LPS pre-treatment inhibited some functions of IFN¦Ã signalling via the activities of these proteins (Crespo et al., 2002; Dalpke et al., 2003; Stoiber et al., 1999).

Go back
449.0, 693.0
30.0, 30.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 10453004, 12811837, 11870615 Both LPS and IFN¦Ã induced expression of these SOCS proteins (SOCS1 and SOCS3), and LPS pre-treatment inhibited some functions of IFN¦Ã signalling via the activities of these proteins (Crespo et al., 2002; Dalpke et al., 2003; Stoiber et al., 1999

Go back
675.0, 551.0
33.0, 33.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c8 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 12831455, 11672593, 7999637, 12811837, 11964313 IFN¦Ã stimulation induced Tlr2, Tlr4, and Tlr6 mRNAs, upregulated expression of TLR2 and TLR4 protein at the cell surface, and increased resulting LPS-binding ability of macrophages

Go back
481.0, 801.0
30.0, 30.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 15928677 LPS induces expression of negative regulators of key adaptor/signalling molecules (e.g. IRAK-M and SOCS1 that target IRAKs, ST2L that sequesters MyD88 and MAL) (Liew et al., 2005).

Go back
1126.0, 426.0
29.5, 29.5

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m71*m36*0.1

nodelay

--

true

0

false

PMID: 16920490, 12811837, 12686553 Signalling initiated by a number of TLR agonists (e.g. LPS, CpG DNA, lipotechoic acid) induced STAT1 S727 phosphorylation, via activation of p38 MAPK pathways (

Go back
897.0, 1049.0
30.0, 30.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c77 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 16920490, 15928677 LPS induces expression of negative regulators of key adaptor/signalling molecules (e.g. IRAK-M and SOCS1 that target IRAKs, ST2L that sequesters MyD88 and MAL) (Liew et al., 2005).

Go back
485.0, 229.0
30.0, 30.0

p33

p33

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 16920490, 9864217 IFN¦Ã pre-treatment of RAW264.7 cells promoted LPS-induced NF-¦ÊB activation and DNA binding kinetics, as well as causing more rapid degradation of the NF-¦ÊB inhibitor, I¦ÊB¦Á (Held et al., 1999)

Go back
273.0, 453.0
30.0, 30.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c84 : 1
stoichiometry:c83 : 1

m49*m64*m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 9864217 IFN¦Ã pre-treatment of RAW264.7 cells promoted LPS-induced NF-¦ÊB activation and DNA binding kinetics, as well as causing more rapid degradation of the NF-¦ÊB inhibitor, I¦ÊB¦Á (Held et al., 1999)

Go back
789.0, 193.0
30.0, 30.0

p35

p35

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c87 : 1
stoichiometry:c75 : 1

m47*m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 9864217 IFN¦Ã pre-treatment of RAW264.7 cells promoted LPS-induced NF-¦ÊB activation and DNA binding kinetics, as well as causing more rapid degradation of the NF-¦ÊB inhibitor, I¦ÊB¦Á

Go back
673.0, 913.0
30.0, 30.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490 IFN¦Ã also influenced the activity of another key LPS-induced transcription factor, AP-1, in human monocytes.

Go back
169.0, 329.0
30.0, 30.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c120 : 1
stoichiometry:c94 : 1

m67*m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 11972023, 10975834, 9649436 In the case of TLR4, LPS treatment following IFN¦Ã exposure increased the percentage of STAT1 molecules phosphorylated on both Y701 and S727, and subsequent STAT1 DNA-binding activity relative to IFN¦Ã treatment alone

Go back
157.0, 605.0
30.0, 30.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 16920490, 12667213, 9568729 IFN¦Ã signalling induced Inos mRNA via STAT1, but induction was maximal only when the Inos promoter NF-¦ÊB sites were occupied following TLR ligation

Go back
329.0, 721.0
30.0, 30.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 2498530 IFN-gamma stimulation induces Ifn-beta mRNA.

Go back
692.0, 624.0
32.0, 32.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c9 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 11964313, 12811837, 7999637, 1167259 IFN¦Ã stimulation induced Tlr2, Tlr4, and Tlr6 mRNAs, upregulated expression of TLR2 and TLR4 protein at the cell surface, and increased resulting LPS-binding ability of macrophages

Go back
949.0, 393.0
30.0, 30.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c113 : 1
stoichiometry:c88 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 16920490, 15928677 LPS induces expression of negative regulators of key adaptor/signalling molecules (e.g. IRAK-M and SOCS1 that target IRAKs, ST2L that sequesters MyD88 and MAL) (Liew et al., 2005).

Go back
333.0, 453.0
30.0, 30.0

p34

p41

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1

m64*m49*m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 9864217 IFN¦Ã pre-treatment of RAW264.7 cells promoted LPS-induced NF-¦ÊB activation and DNA binding kinetics, as well as causing more rapid degradation of the NF-¦ÊB inhibitor, I¦ÊB¦Á (Held et al., 1999)

Go back
105.0, 861.0
30.0, 30.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c116 : 1
stoichiometry:c119 : 1

m74*m67*0.1

nodelay

--

true

0

false

PMID: 16920490, 12811837, 12686553 Signalling initiated by a number of TLR agonists (e.g. LPS, CpG DNA, lipotechoic acid) induced STAT1 S727 phosphorylation, via activation of p38 MAPK pathways

Go back
397.0, 957.0
30.0, 30.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m72*m73*0.1

nodelay

--

true

0

false

PMID: 16920490, 12811837, 12686553 Signalling initiated by a number of TLR agonists (e.g. LPS, CpG DNA, lipotechoic acid) induced STAT1 S727 phosphorylation, via activation of p38 MAPK pathways

Go back
461.0, 1089.0
30.0, 30.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m23*m73*0.1

nodelay

--

true

0

false

PMID: 16920490, 12811837, 12686553 Signalling initiated by a number of TLR agonists (e.g. LPS, CpG DNA, lipotechoic acid) induced STAT1 S727 phosphorylation, via activation of p38 MAPK pathways

Go back
241.0, 1177.0
30.0, 30.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c102 : 1
stoichiometry:c104 : 1

m73*m33*0.1

nodelay

--

true

0

false

PMID: 16920490, 12811837, 12686553 Signalling initiated by a number of TLR agonists (e.g. LPS, CpG DNA, lipotechoic acid) induced STAT1 S727 phosphorylation, via activation of p38 MAPK pathways

Go back
345.0, 373.0
30.0, 30.0

p46

p46

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 16920490, 10975834, 9649436 In the case of TLR4, LPS treatment following IFN¦Ã exposure increased the percentage of STAT1 molecules phosphorylated on both Y701 and S727, and subsequent STAT1 DNA-binding activity relative to IFN¦Ã treatment alone

Go back
289.0, 813.0
30.0, 30.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c11 : 1
stoichiometry:c125 : 1

m75*m64*0.1

nodelay

--

true

0

false

PMID: 16920490, 10975834, 9649436 In the case of TLR4, LPS treatment following IFN¦Ã exposure increased the percentage of STAT1 molecules phosphorylated on both Y701 and S727, and subsequent STAT1 DNA-binding activity relative to IFN¦Ã treatment alone

Go back
177.0, 165.0
30.0, 30.0

p37

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m67*m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 11972023, 10975834, 9649436 STAT1 is phosphorylated at both sites following IFN¦Ã exposure; the IFN¦Ã receptor/JAK complex directly mediates Y701 phosphorylation, whereas S727 phosphorylation occurs via a separate pathway involving Ca(2+)/calmodulin-dependent kinase II

Go back
441.0, 857.0
30.0, 30.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 16816106 Recent studies from our laboratory showed that Hdac1 mRNA was induced by LPS in BMM and that HDACs acted as negative feedback regulators of a sub-set of LPS-inducible genes, including Cox2

Go back
725.0, 317.0
30.0, 30.0

p5

p5

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c14 : 1
stoichiometry:c12 : 1

m12*m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 12831455, 11672593, 7999637, 12811837, 11964313 IFN¦Ã stimulation induced Tlr2, Tlr4, and Tlr6 mRNAs, upregulated expression of TLR2 and TLR4 protein at the cell surface, and increased resulting LPS-binding ability of macrophages

Go back
577.0, 1077.0
30.0, 30.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 16920490, 16816106 Recent studies from our laboratory showed that Hdac1 mRNA was induced by LPS in BMM and that HDACs acted as negative feedback regulators of a sub-set of LPS-inducible genes, including Cox2

Go back
225.0, 833.0
30.0, 30.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m78*m82*0.1

nodelay

--

true

0

false

PMID: 16920490, 14645718, 16481475 Further, STAT1 and HDAC1 physically interact (Nusinzon and Horvath, 2003) and STAT1 is an acetylated protein

Go back
677.0, 985.0
30.0, 30.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 16816106 Recent studies from our laboratory showed that Hdac1 mRNA was induced by LPS in BMM and that HDACs acted as negative feedback regulators of a sub-set of LPS-inducible genes, including Cox2

Go back
637.0, 633.0
30.0, 30.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c143 : 1
stoichiometry:c141 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 14920490, 16164016 Both IFN¦Ã and LPS induce Icsbp mRNA in macrophages, but induction is dependent on the presence of CSF-1 Coupled with the studies from our laboratory described above, demonstrating that ICSBP expression was modulated by both IFN¦Ã (positively) and CSF-1 (negatively), this implies that ICSBP functions to integrate CSF-1 and IFN¦Ã signalling directly into the TLR signalling pathway, by directly modulating TRAF6 function.

Go back
757.0, 753.0
30.0, 30.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c86 : 1
stoichiometry:c142 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 16164016 Both IFN¦Ã and LPS induce Icsbp mRNA in macrophages, but induction is dependent on the presence of CSF-1

Go back
857.0, 965.0
30.0, 30.0

p55

p55

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m84*0.1

nodelay

--

true

0

false

PMID:16920490, 8456286, 16484229 S148-phosphorylated PU.1 is able to interact with ICSBP upon composite PU.1/IRF sites to potentiate PU.1-dependent transactivation the Ets family member PU.l is phosphorylated by LPS and interacts with IFN¦Ã-induced ICSBP ICSBP may participate more directly in the TLR signalling pathway, via interaction with TRAF6

Go back
749.0, 1245.0
30.0, 30.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m85*m86*0.1

nodelay

--

true

0

false

PMID: 14920490, 16484229 In addition to its function as a transcription factor, a recent article suggested that ICSBP may participate more directly in the TLR signalling pathway, via interaction with TRAF6

Go back
549.0, 1241.0
30.0, 30.0

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c112 : 1
stoichiometry:c151 : 1

m88*m23*0.1

nodelay

--

true

0

false

PMID: 16920490, 7609733 PU.1 is phosphorylated at S148 in response to LPS, and phosphorylation is necessary for the full spectrum of macrophage responses to LPS (e.g. induction of IL-1¦Â (Buras et al., 1995)

Go back
657.0, 1385.0
30.0, 30.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m89*m85*0.1

nodelay

--

true

0

false

PMID: 16920490, 8456286,1729611 S148-phosphorylated PU.1 is able to interact with ICSBP upon composite PU.1/IRF sites to potentiate PU.1-dependent transactivation the Ets family member PU.l is phosphorylated by LPS and interacts with IFN¦Ã-induced ICSBP

Go back
829.0, 169.0
30.0, 30.0

p35

p59

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c149 : 1
stoichiometry:c128 : 1

m47*m11*0.1

nodelay

--

true

0

false

PMID: 16920490, 9864217 IFN¦Ã pre-treatment of RAW264.7 cells promoted LPS-induced NF-¦ÊB activation and DNA binding kinetics, as well as causing more rapid degradation of the NF-¦ÊB inhibitor, I¦ÊB¦Á

Go back
669.0, 209.0
30.0, 30.0

p7

p7

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c42 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 16920490, 11964313, 12811837, 7999637, 11672593, 12831455 IFN¦Ã stimulation induced Tlr2, Tlr4, and Tlr6 mRNAs, upregulated expression of TLR2 and TLR4 protein at the cell surface, and increased resulting LPS-binding ability of macrophages

Go back
785.0, 261.0
30.0, 30.0

p8

p8

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c48 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 16920490, 11964313, 12811837, 7999637, 11672593, 12831455 IFN¦Ã stimulation induced Tlr2, Tlr4, and Tlr6 mRNAs, upregulated expression of TLR2 and TLR4 protein at the cell surface, and increased resulting LPS-binding ability of macrophages

Go back
1178.5, 307.0
29.0, 29.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m18*m17*0.1

nodelay

--

true

0

false

PMID: 16920490, 1698311 In the case of LPS, efficient ligand recognition requires the signalling receptor TLR4, as well as the CD14 co-receptor

Go back
1156.0, 45.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 350.1214751973158

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1078.0, 463.11581903007675

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1085.718672204681, 456.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.9751425123042, 1193.6301602244178

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.0, 142.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 1131.496091059235

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.8709417065809, 767.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
197.0, 1032.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
370.9962541943164, 1104.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.55583541102635, 527.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
197.0, 977.8669836198026

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
307.27832494516167, 535.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.54615269175684, 987.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.55416076976337, 896.7577164000688

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.6324189347207, 775.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.0, 426.9945289393368

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
349.6135719910779, 490.97643588401263

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.65685424949237, 395.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
121.30044150023174, 249.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.87768608679755, 483.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.4172039949095, 476.99751311888673

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
125.0, 375.59100473621385

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.4278135270821, 286.9711254108328

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
206.23932883007492, 354.40471997233925

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.0, 364.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.19776902317903, 403.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.0, 628.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.0, 825.2889679298512

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
201.0, 195.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
214.988088110924, 133.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.9146434206434, 140.1655125585194

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.8576205317542, 760.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.9195959492893, 874.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 900.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.0, 1107.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
236.0, 290.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.2166888361404, 865.035154408219

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.0, 855.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.6717280154672, 769.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.9778159408783, 1001.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 1018.5777087639997

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
668.9928144210829, 151.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.8124708171753, 142.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.9938071858317, 757.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
667.0, 653.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 715.72987951681

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.5982446971087, 456.0

c143

c143

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
796.0, 708.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.0, 995.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.016770142732, 1206.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.0, 1265.905772222381

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 1275.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.7937445760541, 136.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
422.0, 1249.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.8350918509939, 1271.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 1338.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.7513776937313, 1211.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.998811204392, 1396.1379105380067

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.0, 210.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.0, 276.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 237.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.0, 259.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.0, 71.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.921188267367, 307.12016803780944

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1082.0, 400.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 768.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1082.393204354514, 575.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.0, 321.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.0, 477.7257215188587

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1078.392524350726, 471.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.0, 685.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 757.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.8220353187476, 768.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1087.5255253311716, 105.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.0, 717.2582661881639

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1003.0, 723.8202717448695

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.7350235949796, 721.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.0, 772.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.0, 850.5777087639997

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.0830176752731, 855.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1081.0, 1031.885977985435

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.0, 955.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1085.4782126851974, 1036.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.0, 691.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.5065284065516, 148.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1080.0, 1168.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.5465242812604, 1182.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.0, 230.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.98314660895767, 249.25845427191362

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.892432618102, 699.3074813072157

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
609.6921915811266, 670.197769023179

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.9955592558332, 733.2665186418611

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.9881971448602, 737.4344034701132

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
813.0, 291.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.4187375300114, 144.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
712.191314408537, 150.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
590.897233121606, 429.40579702813875

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 373.6730668941481

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 387.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.9982794567545, 448.0

c53

c53

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
355.0, 209.77059355888153

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.22576947168176, 241.365250793376

c55

c55

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
830.0, 573.0989135370542

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.0237707010416, 494.9342229330722

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.7888543819998, 582.5777087639997

c58

c58

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
707.8145387273365, 161.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
723.5970433718076, 154.0

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
637.8201683526586, 799.6867029780244

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.4077653398708, 155.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
800.0, 547.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.2170737730852, 139.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.0, 447.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.560383117279, 143.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.1857337763822, 555.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.6872556354166, 762.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.8587085313798, 871.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.2972991267998, 144.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.2667691281392, 419.6721416644712

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.0, 627.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.7721102797587, 147.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
479.0, 711.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.955714006016, 758.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
462.0659023220581, 774.1916583936265

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.7611400011626, 142.94028500029066

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.0, 479.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.0, 1028.5339352927588

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0, 412.4861988880742

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.18672362344194, 149.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.4861652793936, 538.8208738733947

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.4129494057038, 259.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
309.8823322690734, 395.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.7931034482759, 487.51724137931035

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.73533539373636, 483.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.3414020752537, 139.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.0, 149.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.6968333799565, 466.0

c86

c86

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
814.3910150092254, 230.24575856672084

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
966.0, 423.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.0, 201.18181003620188

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.5731992484011, 604.5781103824345

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.2636750760037, 765.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.8824641631971, 930.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
193.0, 1056.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.0, 249.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.0, 345.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
182.3173647847399, 368.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
187.0, 622.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.1326368264808, 145.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
237.80949648147163, 712.7354436625493

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1162.0621504188273, 397.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back