1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16978535.csml convertedTime:2009.07.01.10:57

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derivedinflammatory mediators.
Authors Harizi H, Gualde N.
Affiliation CNRS UMR 5540, Bordeaux, Universite Bordeaux 2, France. harizihedi33@yahoo.fr
Abstract Exposure to pathogens induces antigen-presenting cells (APC) such as macrophagesand dendritic cells (DC) to produce various endogenous mediators, includingarachidonic acid (AA)-derived eicosanoids, cytokines, and nitric oxide (NO).Many secreted products of activated APC can act by themselves in an autocrinemanner and modulate their function. Moreover, the cross-interaction betweenendogenous bioactive molecules regulates the function of professional APC withimportant consequences for their ability to activate and sustain immune andinflammatory responses, and to regulate immune homeostasis. Although neglectedfor many years when compared to their role in cardiovascular homeostasis, cancerand inflammation, the importance of eicosanoids in immunology is becoming moredefined. The role of prostaglandin (PG) E2 (PGE2), one of the best known andmost well studied eicosanoids, is of particular interest. It modulates theactivities of professional DC by acting on their differentiation, maturation andtheir ability to secrete cytokines. Uniquely among haematopoietic cytokines,interleukin-10 (IL-10) is a pleiotropic molecule that displays bothimmunostimulatory and immunoregulatory activities. IL-10 has attached muchattention because of its anti-inflammatory properties. It modulates expressionof cytokines, soluble mediators and cell surface molecules by cells of myeloidorigin, particularly macrophages and DC. We previously reported that PGE2 is apotent inducer of IL-10 in bone marrow-derived DC (BM-DC), and PGE2-inducedIL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. BM-DC may beconsidered as an important model to study complex interactions betweenendogenous mediators, and autocrine IL-10 plays a pivotal role in thecrossregulation of AA-derived lipid mediators, cytokines, and NO, with criticaleffects on immune and inflammatory responses.
PMID 16978535
Model Abstract

Entity

G010262:IL-6 G010329:TNF-alpha G010657:IL-12 p40 G011345:IL10 MO000000058:NF-kappaB MO000000132:PLC MO000000289:TNF-alpha MO000000332:IP3 MO000007384:IL-6 MO000016598:IL-1RA MO000016656:STATs MO000016882:LPS MO000016894:MAPK MO000017247:IL-10 MO000017265:IL-12 MO000017266:COX-2{active} MO000019394:TLR4 MO000021434:5-LO MO000021939:PGE2 MO000033519:LTB4 e1: e10:IL-1RA e11:EP1:PGE2 e12:PGE2:EP2 e13:EP3 e14:EP3:PGE2 e15:EP4 e16:EP4:PGE2 e17:PLC{active} e18:calcium e19:Adenylate cyclase e2: e20:Adenylate cyclase[active} e21:CAMP e22:Synthetic agonists e23:EP2:PGE2:synthetic agonists e24:EP4:PGE2:synthetic agonists e25:di-butryl CAMP e26:EP2:PGE2:di-butryl CAMP e27:EP4:PGE2:di-butryl CAMP e28:NS-398 e29:LPS:TLR4 e3: e30:NF-kappaB{active} e31:MAPK{active} e32:cox-2 e33:PGE2 e35:IL-10R1 e36:IL-10R2 e37:IL-10R1:IL-10R2 e38:IL-10R:IL-10 e39:STATs{active} e4: e40:degradants e41:proinflammatory cytokine e42:proinflammatory cytokines e43:FLAP e44:IL-4 e45:IL-13 e46:COX-1{active} e47:iNOS e48:NO e49:COX-1 e5:EP1 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:EP2 e60: e61: e62: e63:COX-2{inactive} e64:NF-kappaB{active} e65:DNA e66:NF-KappaB{active}:DNA e67:iNOS e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p6 p7 p8 p9
Model Detail
698.0, 1134.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p32 p36

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
631.0, 963.0
26.0, 26.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
527.0, 899.0
34.0, 34.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p1 p31

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
702.0, 962.0
27.0, 27.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
884.0, 1192.0
24.5, 24.5

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
904.0, 380.0
23.0, 23.0

PLC

--

MO000000132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
667.0, 227.0
25.0, 25.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
699.0, 483.0
18.0, 18.0

IP3

--

MO000000332

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p9

true true true true

csml-variable:Double

m290230

10

false

infinite

0

unit false false false
TRANSPATHMO000000332

--

Go back
1285.0, 1121.0
22.0, 22.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p36

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1108.0, 1284.0
24.0, 24.0

IL-1RA

--

MO000016598

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m1592

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000016598

--

Go back
929.0, 1555.0
18.0, 18.0

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false

--

Go back
1222.0, 1050.0
27.0, 27.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
848.0, 1360.0
24.0, 24.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
1247.0, 987.0
25.5, 25.5

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1223.0, 883.0
25.5, 25.5

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1 p31

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
633.0, 1413.0
22.0, 22.0

COX-2{active}

--

MO000017266

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2122

10

false

infinite

0

unit false false false
InterProIPR002016
TRANSPATHMO000017266

--

Go back
1105.0, 1169.0
22.0, 22.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

--

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
269.0, 741.0
22.0, 22.0

5-LO

--

MO000021434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m5784

10

false

infinite

0

unit false false false
TRANSPATHMO000021434

--

Go back
1200.0, 696.0
31.0, 31.0

PGE2

--

MO000021939

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p3 p4 p5 p6 p31 p46

true true true true

csml-variable:Double

m346644

10

false

infinite

0

unit false false false
TRANSPATHMO000021939

--

Go back
362.0, 790.0
20.0, 20.0

LTB4

--

MO000033519

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m341991

10

false

infinite

0

unit false false false
TRANSPATHMO000033519

--

Go back
94.67169173689427, 270.78894623828853
1063.7224263098356, 1544.5249630018811

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
632.0, 1203.0
47.128027681660896, 25.134948096885815

IL-1RA

--

e10

cso30:c:mRNA

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
1105.5, 412.0
21.01556676167507, 40.675290506467874

EP1:PGE2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1100.5, 558.0
23.081780311335233, 44.67441350581013

PGE2:EP2

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1103.5, 616.0
25.38312829525483, 39.05096660808436

EP3

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1109.5, 683.0
21.341811006358252, 41.306730980048236

EP3:PGE2

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1106.5, 747.0
26.662565905096663, 41.019332161687174

EP4

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6 p28

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1105.5, 839.0
21.987502740627054, 42.556456917342686

EP4:PGE2

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
780.0, 424.0
23.0, 23.0

PLC{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p8

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000132

--

Go back
664.5, 564.0
23.929953396412937, 24.335545826860603

calcium

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
944.5, 476.0
15.190179110485007, 24.632722881867576

Adenylate cyclase

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p13

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
94.67169173689427, 270.78894623828853
1063.7224263098356, 1544.5249630018811

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
884.5, 556.0
15.190179110485007, 24.632722881867576

Adenylate cyclase[active}

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
708.5, 628.0
23.613331450360107, 24.013557407145875

CAMP

--

e21

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1277.0, 603.5
22.56, 16.919999999999998

Synthetic agonists

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12 p14

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1007.5, 291.0
24.79464121857222, 34.59717379335659

EP2:PGE2:synthetic agonists

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1103.5, 955.0
24.79464121857222, 34.59717379335659

EP4:PGE2:synthetic agonists

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1344.5, 660.0
23.613331450360107, 24.013557407145875

di-butryl CAMP

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p17 p20

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
836.5, 292.0
23.15323912644522, 32.306845292714264

EP2:PGE2:di-butryl CAMP

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1108.5, 1092.0
23.15323912644522, 32.306845292714264

EP4:PGE2:di-butryl CAMP

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1310.0, 957.0
12.841908325537885, 29.63517305893358

NS-398

--

e28

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p16 p18

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1105.5, 1220.0
20.172769129576846, 39.04406928305196

LPS:TLR4

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
115.946140263091, 292.06339476448534
1021.1735292574418, 1501.9760659494877

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
788.0, 1296.0
24.5, 24.5

NF-kappaB{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
944.0, 1412.0
24.0, 24.0

MAPK{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
549.0, 1160.0
45.674740484429066, 24.3598615916955

cox-2

--

e32

cso30:c:mRNA

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
784.0, 1508.0
31.0, 31.0

PGE2

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000021939

--

Go back
1102.0, 1385.5
28.66572751056551, 17.677198631515395

IL-10R1

--

e35

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p37

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1103.0, 1434.5
25.600000000000005, 19.200000000000003

IL-10R2

--

e36

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p37

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1108.0, 1486.0
24.861878453038678, 27.6243093922652

IL-10R1:IL-10R2

--

e37

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1105.5, 1320.0
21.1311115983337, 40.898925674194246

IL-10R:IL-10

--

e38

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
995.0, 1615.0
18.0, 18.0

STATs{active}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false

--

Go back
155.30387003655514, 329.2936796853294
942.4580697105139, 1427.5154961077983

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
472.0, 1164.0
23.95175186674326, 23.15336013785181

degradants

--

e40

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p40

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
420.0, 1059.0
47.85467128027682, 25.522491349480973

proinflammatory cytokine

--

e41

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

--

p41

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
304.0, 1190.0
15.894293732460241, 36.67913938260055

proinflammatory cytokines

--

e42

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p41

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
243.5, 938.0
16.962366673374927, 27.506540551418794

FLAP

--

e43

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
383.0, 1847.5
26.79412356610988, 16.523042865767763

IL-4

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p24

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
510.5, 1841.0
18.637754075266656, 30.2233849869189

IL-13

--

e45

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p24

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
465.0, 1409.0
22.0, 22.0

COX-1{active}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR002016
TRANSPATHMO000017266

--

Go back
428.0, 783.0
15.067352666043028, 34.77081384471468

iNOS

--

e47

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
487.0, 616.0
42.28763666947013, 23.962994112699743

NO

--

e48

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
313.0, 1305.0
22.0, 22.0

COX-1

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
InterProIPR002016
TRANSPATHMO000017266

--

Go back
1104.5, 350.0
23.23550087873462, 35.74692442882249

EP1

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
350.8367325514072, 853.514631602477
481.51894799066054, 436.6847815110838

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
402.8443656677166, 863.8634260844726
281.5585654917458, 423.23453156721075

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
357.1135158585482, 859.3430732448219
468.96538137637924, 425.02789822639375

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
358.01019918813995, 860.2397565744127
467.17201471719534, 423.23453156721075

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
350.8367325514072, 853.514631602477
481.51894799066054, 436.6847815110838

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
350.8367325514072, 853.514631602477
481.51894799066054, 436.6847815110838

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
353.8482117522292, 861.072154061595
467.17201471719534, 423.23453156721075

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
702.3365977512932, 1032.8512975207848
30.082658162635074, 27.23272212617499

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
623.4284647472375, 1158.386963663603
85.18491631119683, 77.11476634487322

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
350.8367325514072, 853.514631602477
481.51894799066054, 436.6847815110838

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1102.5, 483.0
27.37082601054481, 42.108963093145874

EP2

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4 p51

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
464.3280392721722, 1047.5737401499473
15.248997565090562, 7.342109938747314

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
463.8188320799419, 1025.6778308840544
52.19373720358343, 93.94872696645031

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
485.7147413458363, 1086.7826939516654
8.147315075681297, 8.147315075681307

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
617.0, 1533.0
22.0, 22.0

COX-2{inactive}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
InterProIPR002016
TRANSPATHMO000017266

--

Go back
652.0, 1012.0
24.5, 24.5

NF-kappaB{active}

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
750.0, 1057.5
51.61050676572035, 11.182276465906074

DNA

--

e65

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p47

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
606.0, 1127.5
60.0, 17.0

NF-KappaB{active}:DNA

--

e66

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
391.0, 993.0
41.003460207612456, 21.868512110726645

iNOS

--

e67

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
108.64745289089842, 277.00423678905156
1043.1802989021514, 1478.1595379277724

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
112.37432253196653, 303.092324276526
1000.73529103373, 1453.067642580977

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
122.31264157481371, 307.18041176400055
996.1663854924351, 1434.0110245543347

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
837.0, 913.0
21.0, 21.0

p1

p1

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c93 : 1
stoichiometry:c1 : 1

m93589*m346644*m230*0.1

nodelay

--

true

0

false

PMID: 16978535,9348319 On the contrary, PGE2 has also been shown to stimulate DC and promote IL-12 production when given in combination with TNF-alpha PMID: 16978535 The fact that PGE2 and IL-10 strongly inhibit the production of IL-12 implies a feedback mechanism at the level of the APC, and may represent an important mean controlling the differentiation of APC from bone marrow progenitors or from circulating monocytes.

Go back
984.0, 556.0
22.0, 22.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m12*m19*0.1

nodelay

--

true

0

false

PMID: 16978535 The EP2 and EP4 receptors signal by stimulating adenylate cyclase, which increases the intracellular levels of cAMP.

Go back
813.0, 629.0
21.0, 21.0

p11

p11

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 16978535 The EP2 and EP4 receptors signal by stimulating adenylate cyclase, which increases the intracellular levels of cAMP. PMID: 16978535 The molecular mechanisms by which PGE2 possibly inhibits iNOS expression could be related to its ability to increase intracellular cAMP levels, which in turn inhibit NF-KappaB/DNA binding activity.

Go back
1277.0, 481.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m22*m12*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC

Go back
969.0, 649.0
22.0, 22.0

p10

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m16*m19*0.1

nodelay

--

true

0

false

PMID: 16978535 The EP2 and EP4 receptors signal by stimulating adenylate cyclase, which increases the intracellular levels of cAMP.

Go back
1277.0, 701.0
21.0, 21.0

p12

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 e22

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m16*m22*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC

Go back
878.0, 1026.0
19.0, 19.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m24*m94230*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC

Go back
866.0, 786.0
19.0, 19.0

p15

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c46 : 1

m94230*m23*m155666*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC PMID: 16978535 Agonists of cAMP-elevating receptors, such as butaprost (EP2 receptor), dose-dependently enhanced IL-10 production from LPS-stimulated BM-DC PMID: 16978535,11859113 The enhanced BM-DC release of IL-10 observed after LPS stimulation appears to be closely connected to COX-2 activity as the COX-2-selective inhibitor NS-398 significantly reduced IL-10 levels

Go back
1345.0, 569.0
21.0, 21.0

p12

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m25*m12*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC

Go back
866.0, 674.0
19.0, 19.0

p15

p18

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c52 : 1

m26*m94230*m155666*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC PMID: 16978535 Agonists of cAMP-elevating receptors, such as butaprost (EP2 receptor), dose-dependently enhanced IL-10 production from LPS-stimulated BM-DC PMID: 16978535,11859113 The enhanced BM-DC release of IL-10 observed after LPS stimulation appears to be closely connected to COX-2 activity as the COX-2-selective inhibitor NS-398 significantly reduced IL-10 levels

Go back
910.0, 1058.0
19.0, 19.0

p15

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c57 : 1
stoichiometry:c59 : 1

m94230*m27*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC

Go back
849.0, 965.0
21.0, 21.0

p2

p2

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c5 : 1

m94230*m346644*m155666*0.1

nodelay

--

true

0

false

PMID: 16978535,7525853,8739216,9464843 Previous studies showed that PGE2 up-regulates the production of IL-10 by macrophages and T cells PMID: 16978535,1940799 In monocytes, IL-10 synthesis was found to be enhanced after LPS exposure, suggesting that IL-10 may regulate the inflammatory response to LPS.

Go back
1345.0, 817.0
21.0, 21.0

p12

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c58 : 1

m25*m16*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113 Using EP receptor-selective synthetic agonists and dibutyryl cAMP, we demonstrated that PGE2-EP2 and -EP4 signaling stimulate the production of IL-10 by BM-DC

Go back
1252.0, 1180.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 16978535 In fact, microbial products such as LPS activate TLR4-derived signaling pathways including NF-KappaB and/or MAPK, which results in the induction of cyclooxygenase (COX)-2 and the production of PGE2 PMID: 16978535 Figure 1

Go back
1002.0, 1234.0
19.0, 19.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m29*m30*0.1

nodelay

--

true

0

false

PMID: 16978535 In fact, microbial products such as LPS activate TLR4-derived signaling pathways including NF-KappaB and/or MAPK, which results in the induction of cyclooxygenase (COX)-2 and the production of PGE2 PMID: 16978535 Figure 1

Go back
982.0, 1302.0
19.0, 19.0

p22

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m29*m1812*0.1

nodelay

--

true

0

false

PMID: 16978535 In fact, microbial products such as LPS activate TLR4-derived signaling pathways including NF-KappaB and/or MAPK, which results in the induction of cyclooxygenase (COX)-2 and the production of PGE2 PMID: 16978535 Figure 1

Go back
593.0, 1329.0
21.0, 21.0

p24

p24

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c116 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c74 : 1

m33*m31*0.1

nodelay

--

true

0

false

PMID: 16978535 In fact, microbial products such as LPS activate TLR4-derived signaling pathways including NF-KappaB and/or MAPK, which results in the induction of cyclooxygenase (COX)-2 and the production of PGE2 PMID: 16978535 Figure 1 PMID: 16978535 Pro-inflammatory cytokines, such as TNF-¦Á are also able to induce COX-2 expression and PGE2 production by cells of immune system, particularly DC. PMID: 16978535,15219461 Moreover, we have recently demonstrated that IL-10 suppresses COX-2 protein expression and PG production in BM-DC PMID: 16978535 Antiinflammatory cytokines, such as IL-4, IL-13, and IL-10 can inhibit COX-2 induction.

Go back
689.0, 1357.0
21.0, 21.0

p24

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m33*m32*0.1

nodelay

--

true

0

false

PMID: 16978535 In fact, microbial products such as LPS activate TLR4-derived signaling pathways including NF-KappaB and/or MAPK, which results in the induction of cyclooxygenase (COX)-2 and the production of PGE2 PMID: 16978535 Figure 1

Go back
689.0, 1477.0
21.0, 21.0

p26

p26

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c117 : 1
stoichiometry:c80 : 1

m2122*0.1

nodelay

--

true

0

false

PMID: 16978535 In fact, microbial products such as LPS activate TLR4-derived signaling pathways including NF-KappaB and/or MAPK, which results in the induction of cyclooxygenase (COX)-2 and the production of PGE2 PMID: 16978535 Figure 1 PMID: 16978535,15219461 Moreover, we have recently demonstrated that IL-10 suppresses COX-2 protein expression and PG production in BM-DC PMID: 16978535 The COX enzyme exists in two isoforms: COX-1, a constitutive form that is expressed in multiple cell types and is thought to produce PGs central to physiologic homeostasis, and COX-2, an inducible form that is rapidly up-regulated in response to inflammatory stimuli and is responsible for the production of large amounts of PGs at the inflammation site. PMID: 16978535 PGE2 and NO are two pleiotropic mediators produced at inflammatory sites by the inducible enzymes, COX-2 and nitric oxide synthase (iNOS), respectively.

Go back
553.0, 1025.0
21.0, 21.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 16978535 Pro-inflammatory cytokines, such as TNF-alpha are also able to induce COX-2 expression and PGE2 production by cells of immune system, particularly DC.

Go back
885.0, 1485.0
21.0, 21.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m34*m15*0.1

nodelay

--

true

0

false

PMID: 16978535 Since BM-DC express EP receptors at their surface, they become target to autocrine and paracrine PGE2, which by binding to EP2 and/or EP4 acts on DC and induces the production of endogenous IL-10.

Go back
778.0, 790.0
19.0, 19.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c153 : 1
stoichiometry:c88 : 1

m16*m94230*0.1

nodelay

--

true

0

false

PMID: 16978535 Since BM-DC express EP receptors at their surface, they become target to autocrine and paracrine PGE2, which by binding to EP2 and/or EP4 acts on DC and induces the production of endogenous IL-10.

Go back
1197.0, 357.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m346644*m5*0.1

nodelay

--

true

0

false

PMID: 16978535 Based on pharmacological and cDNA cloning studies, four subtypes of PGE receptors designated EP receptors (EP1, EP2, EP3 and EP4) have been identified and have been shown to differ in their signal transduction pathways.

Go back
690.0, 798.0
19.0, 19.0

p29

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c98 : 1

m94230*m12*0.1

nodelay

--

true

0

false

PMID: 16978535 Since BM-DC express EP receptors at their surface, they become target to autocrine and paracrine PGE2, which by binding to EP2 and/or EP4 acts on DC and induces the production of endogenous IL-10.

Go back
761.0, 729.0
21.0, 21.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m93589*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113,7836930 We and other have demonstrated that PGE2 produced by DC is a potent inhibitor of human and murine IL-12 PMID: 16978535 The fact that PGE2 and IL-10 strongly inhibit the production of IL-12 implies a feedback mechanism at the level of the APC, and may represent an important mean controlling the differentiation of APC from bone marrow progenitors or from circulating monocytes.

Go back
853.0, 1121.0
21.0, 21.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c152 : 1
stoichiometry:c95 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 16978535,11859113,15219461 We have previously reported that PGE2 inhibits the production of IL-6 and TNF-alpha via induction of endogenous IL-10

Go back
528.0, 656.0
23.0, 23.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c99 : 1
stoichiometry:c97 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 16978535,1611085,8070901,2651547,11602631 In macrophage, IL-6, a cytokine with critical role in maturation of humoral immune response, is positively regulated by PGE2, whereas TNF-alpha release is inhibited by PGE2 PMID: 16978535,11859113,15219461 We have previously reported that PGE2 inhibits the production of IL-6 and TNF-alpha via induction of endogenous IL-10

Go back
270.0, 846.0
19.0, 19.0

p34

p34

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c101 : 1

m5784*m44*0.1

nodelay

--

true

0

false

PMID: 16978535,12496393 We also demonstrated that leucotriene B4 (LTB4), a pro-inflammatory metabolite synthesized by the action of 5-Lipoxygenase (5-LO) enzyme, induces the production of IL-6 without any effect on TNF-alpha PMID: 16978535,12496393 We have previously reported that endogenous IL-10 inhibits the production of pro-inflammatory LTB4, which is synthesized from AA by the action of both 5-LO and Five-Lipoxygenaseactivating protein (FLAP) enzymes

Go back
765.0, 1249.0
21.0, 21.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m10*0.1

nodelay

--

true

0

false

Go back
809.0, 1197.0
21.0, 21.0

p36

p36

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m341991*m93248*0.1

nodelay

--

true

0

false

PMID: 16978535,12496393 We also demonstrated that leucotriene B4 (LTB4), a pro-inflammatory metabolite synthesized by the action of 5-Lipoxygenase (5-LO) enzyme, induces the production of IL-6 without any effect on TNF-alpha

Go back
1206.0, 1434.0
19.0, 19.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m36*m37*0.1

nodelay

--

true

0

false

PMID: 16978535,9463407 IL-10 exerts its actions through a heterodimeric membrane receptor formed by a binding chain (IL-10R1) and a transducing chain (IL-10R2, also known as a CFR2-4), whose mutual interaction activates a series of intracellular signaling molecules, including STAT protein

Go back
1194.0, 1338.0
19.0, 19.0

p37

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m2103*m38*0.1

nodelay

--

true

0

false

PMID: 16978535,9463407 IL-10 exerts its actions through a heterodimeric membrane receptor formed by a binding chain (IL-10R1) and a transducing chain (IL-10R2, also known as a CFR2-4), whose mutual interaction activates a series of intracellular signaling molecules, including STAT protein

Go back
982.0, 1502.0
19.0, 19.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m39*m1633*0.1

nodelay

--

true

0

false

PMID: 16978535,9463407 IL-10 exerts its actions through a heterodimeric membrane receptor formed by a binding chain (IL-10R1) and a transducing chain (IL-10R2, also known as a CFR2-4), whose mutual interaction activates a series of intracellular signaling molecules, including STAT protein

Go back
1245.0, 413.0
21.0, 21.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m346644*m6*0.1

nodelay

--

true

0

false

PMID: 16978535 Based on pharmacological and cDNA cloning studies, four subtypes of PGE receptors designated EP receptors (EP1, EP2, EP3 and EP4) have been identified and have been shown to differ in their signal transduction pathways.

Go back
485.0, 1057.0
21.0, 21.0

p40

p40

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m33*m38*0.1

nodelay

--

true

0

false

PMID: 16978535,7780157 For example, it has been reported that exogenous IL-10 may accelerate the degradation of COX-2 mRNA in human monocytes in vitro

Go back
306.0, 1122.0
19.0, 19.0

p41

p41

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c122 : 1

m42*m155666*0.1

nodelay

--

true

0

false

PMID: 16978535,1827484 In contrast, IL-10 is an important inhibitor of pro-inflammatory cytokine synthesis in LPS-stimulated macrophages

Go back
465.0, 1497.0
21.0, 21.0

p42

p42

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 16978535 The COX enzyme exists in two isoforms: COX-1, a constitutive form that is expressed in multiple cell types and is thought to produce PGs central to physiologic homeostasis, and COX-2, an inducible form that is rapidly up-regulated in response to inflammatory stimuli and is responsible for the production of large amounts of PGs at the inflammation site.

Go back
309.0, 657.0
21.0, 21.0

p43

p43

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 16978535 PGE2 and NO are two pleiotropic mediators produced at inflammatory sites by the inducible enzymes, COX-2 and nitric oxide synthase (iNOS), respectively.

Go back
404.0, 1332.0
23.0, 23.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m49*m63*0.1

nodelay

--

true

0

false

PMID: 16978535,10903767 NO can exert divergent effects on the constitutive and inducible isoforms of COX by activating COX-1 and inactivating COX-2 in murine macrophages

Go back
521.0, 1353.0
23.0, 23.0

p45

p45

cso30:i:ME_UnknownInactivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m2122*m49*0.1

nodelay

--

true

0

false

Go back
417.0, 697.0
21.0, 21.0

p46

p46

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
stoichiometry:c140 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 16978535,10903767 Previous studies reported that PGE2 was able to inhibit the LPS-stimulated production of NO in J774 macrophages and murine peritoneal macrophages

Go back
617.0, 1073.0
21.0, 21.0

p47

p47

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c145 : 1
stoichiometry:c144 : 1

m65*m66*0.1

nodelay

--

true

0

false

PMID: 16978535 The molecular mechanisms by which PGE2 possibly inhibits iNOS expression could be related to its ability to increase intracellular cAMP levels, which in turn inhibit NF-KappaB/DNA binding activity.

Go back
493.0, 1005.0
21.0, 21.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 16978535 The molecular mechanisms by which PGE2 possibly inhibits iNOS expression could be related to its ability to increase intracellular cAMP levels, which in turn inhibit NF-KappaB/DNA binding activity.

Go back
392.0, 872.0
23.0, 23.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c154 : 1
stoichiometry:c149 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 16978535 The molecular mechanisms by which PGE2 possibly inhibits iNOS expression could be related to its ability to increase intracellular cAMP levels, which in turn inhibit NF-KappaB/DNA binding activity. PMID: 16978535,9862429 It has previously demonstrated that PGE2 potently suppresses macrophage NO production by preventing NF-¦ÊB activation

Go back
1253.0, 533.0
21.0, 21.0

p3

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m346644*m13*0.1

nodelay

--

true

0

false

PMID: 16978535 Based on pharmacological and cDNA cloning studies, four subtypes of PGE receptors designated EP receptors (EP1, EP2, EP3 and EP4) have been identified and have been shown to differ in their signal transduction pathways.

Go back
489.0, 929.0
21.0, 21.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c150 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 16978535,15219461 Since TNF-alpha has been reported to induce iNOS expression and PGE2 potently suppresses TNF-alpha production, as we have already reported the inhibitory action of PGE2-cAMP system on NO production might be secondary to the inhibition of TNF-alpha generation.

Go back
801.0, 1417.0
21.0, 21.0

p28

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m34*m6*0.1

nodelay

--

true

0

false

PMID: 16978535 Since BM-DC express EP receptors at their surface, they become target to autocrine and paracrine PGE2, which by binding to EP2 and/or EP4 acts on DC and induces the production of endogenous IL-10.

Go back
1261.0, 757.0
21.0, 21.0

p3

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c41 : 1

m15*m346644*0.1

nodelay

--

true

0

false

PMID: 16978535 Based on pharmacological and cDNA cloning studies, four subtypes of PGE receptors designated EP receptors (EP1, EP2, EP3 and EP4) have been identified and have been shown to differ in their signal transduction pathways.

Go back
985.0, 425.0
21.0, 21.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m11*m119*0.1

nodelay

--

true

0

false

PMID: 16978535 The EP1 receptor activates phospholipase C and phosphatidylinositol turnover and stimulates the release of intracellular calcium

Go back
786.0, 494.0
19.0, 19.0

p8

p8

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 16978535 The EP1 receptor activates phospholipase C and phosphatidylinositol turnover and stimulates the release of intracellular calcium

Go back
786.0, 566.0
19.0, 19.0

p8

p9

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m290230*0.1

nodelay

--

true

0

false

PMID: 16978535 The EP1 receptor activates phospholipase C and phosphatidylinositol turnover and stimulates the release of intracellular calcium

Go back
858.0, 897.5684227151417

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1128.0, 368.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 763.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.0, 810.1979831203844

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 809.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
726.0, 1156.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
830.0, 1135.2503758700516

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 1224.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
786.0, 1261.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1131.0, 1401.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1129.0, 1444.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1139.8930451015356, 1450.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.5538553641522, 376.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1207.2639240088533, 1013.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.0, 1364.0085798749974

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.9681132477697, 1341.7135623803972

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1003.7079894070357, 1355.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
947.0, 1526.4929882637098

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
993.0, 1521.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.0, 1340.0

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
713.7712575432186, 1344.0

c117

c117

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
507.72407995507376, 1084.4562426052673

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.5763575007388, 1079.5553838501796

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1218.0, 441.92139982986555

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.9240068653965, 1078.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.2299027111483, 1083.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.488880506236, 1141.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.9784322944324, 1065.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.63603939904704, 1137.6670985239564

c124

c124

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
256.0, 872.688204745

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
292.1742382932568, 865.43397026638

c126

c126

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
399.0, 1353.7092656814755

c127

c127

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
522.0, 1353.9479400783405

c128

c128

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
476.0, 1431.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1130.0, 433.9820997576878

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 1508.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.2718057815604, 684.0173136698619

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
330.0, 633.6932339682015

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.0092134663207, 640.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.0, 1319.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.0, 1355.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.0741663966368, 1374.7357957375498

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.0, 1376.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 640.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.31893676273125, 715.2300409692666

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1129.431740870602, 434.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.0, 645.6568542494924

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.99994488991763, 708.0209970860363

c141

c141

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
639.1716000756318, 1037.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.9195959492894, 1067.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 1094.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.8184165564786, 652.0

c145

c145

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
439.93207624481136, 1007.0402722944015

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.9124128651158, 1030.3891904876718

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
405.488880506236, 902.9850482685217

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.0, 825.5019900857897

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1221.0, 561.7003235347597

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.47440140654027, 948.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.9914081575597, 252.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.7926946715396, 1004.0

c152

c152

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
722.0, 816.4143700824294

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
418.96360999781683, 885.5383268386458

c154

c154

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
802.0, 1445.9346862024595

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.4965671207729, 525.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 610.5418678301722

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.0, 555.2202671450839

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.3469514304013, 554.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.0, 768.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1231.0, 727.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.0, 916.0

c2

c2

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1133.8915041674247, 774.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.9936076697743, 432.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
927.0, 398.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.0, 436.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.0, 447.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
724.9172847920029, 494.14743257855116

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 501.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
696.0, 576.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.9469044952233, 568.9201678889206

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.0, 501.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.9321827142576, 721.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
907.9994331668254, 567.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
839.4929882637098, 576.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.0, 640.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.5078799297219, 677.6090104054397

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
954.0, 501.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.5369606578714, 581.7742589717802

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1288.0, 510.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1124.0, 501.55896510993864

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.5978308147678, 320.5242268444122

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1127.0, 726.2163141506244

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 252.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1288.0, 620.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.8569492644901, 778.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.7033255371181, 975.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.0, 981.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
897.0, 1001.7735017615314

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 810.970874035966

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.0, 801.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.2681635184596, 326.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1356.0, 598.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1124.0, 580.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.0, 977.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0507588735873, 317.7797882621293

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.0, 324.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.0, 691.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0, 700.0201703954069

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.0, 982.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1356.0, 684.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.0, 830.0549269537275

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.8446454055273, 1071.5689290811056

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1137.1589675136784, 838.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.0, 1004.5546894146929

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 976.0

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
888.3474621306408, 692.1896340525133

c60

c60

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
888.713906763541, 801.4855627054164

c61

c61

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
890.500151486109, 698.8093315992335

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
891.4159567743959, 807.7786502978438

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1239.0, 1077.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.974522228289, 1181.6379617782632

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.60738467846, 1196.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.9911565538812, 1240.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
909.0, 1208.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.6592560495949, 1247.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.4232816139664, 724.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1007.9173885591675, 1246.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 1320.3104235544095

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.4290863355067, 1321.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
574.0, 1184.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
609.0, 1350.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.8983888255722, 1310.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 1184.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
717.8165053674129, 1371.7035973236668

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.6568542494924, 1378.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 1435.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.7864661478591, 979.8360133246372

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
710.0, 1492.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 1046.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.1471418058, 252.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.0, 1501.2987830845307

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.358081186546, 788.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 889.5588447502647

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.8717732035985, 803.4265996744385

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.99228446303, 713.0

c87

c87

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
797.0, 804.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.7688384597327, 824.9629697615171

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1208.2011942051715, 385.9974696555727

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
715.9991456642429, 586.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
561.0, 752.9005733234865

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.0, 743.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.933195052618, 926.7279949711786

c93

c93

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
726.0, 1133.8765797378182

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
874.0, 1132.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.5618223885562, 686.5787245661452

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 259.60439013568447

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 811.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.6322956397578, 674.6752397993711

c99

c99

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back