1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16979567.csml convertedTime:2009.07.01.10:57

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Type I interferon [corrected] gene induction by the interferon regulatory factorfamily of transcription factors.
Authors Honda K, Takaoka A, Taniguchi T.
Affiliation Department of Immunology, Graduate School of Medicine and Faculty of Medicine,University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Abstract Induction of type I interferons (IFNs) by viruses and other pathogens is crucialfor innate immunity, and it is mediated by the activation of pattern-recognitionreceptors, such as Toll-like receptors and cytosolic receptors such as RIG-I andMDA5. The type I IFN induction is primarily controlled at the genetranscriptional level, wherein a family of transcription factors, interferonregulatory factors (IRFs), plays central roles. Here, we summarize the recentstudies on IRFs, providing a paradigm of how genes are ingeniously regulatedduring immune responses. We also consider some evolutional aspects on theIFN-IRF system.
PMID 16979567
Model Abstract

Entity

G010228:IFN-beta G010384:IRF-1 G010713:IRF-7 G012252:CXCL10 MO000000030:PI3K MO000000049:c-Jun MO000000058:NF-kappaB MO000000065:RIP1 MO000000209:TRAF2 MO000000212:TRAF6 MO000000248:IKK MO000000279:c-Fos MO000007685:IRF-1 MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016608:IKK-i MO000016660:IFNbeta MO000016665:IFNgamma MO000016899:FADD MO000016963:TRAF3 MO000018132:CD14 MO000018743:RANKL MO000019331:TBK1 MO000019394:TLR4 MO000019398:TLR3 MO000019984:p300 MO000022131:MD-2 MO000022224:dsRNA MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 MO000042409:LPS MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e11:DDX58:viral RNA:MAVS e12:IFIH1:viral RNA:MAVS e13:IFIH1:viral RNA e14:DDX58:viral RNA:MAVS:TRAF2:TRAF5:FADD:RIP1 e15:DDX58:viral RNA:MAVS:TRAF2:TRAF5:FADD:RIP1 e16:IKK{active} e17:DDX58:viral RNA:MAVS:TRAF3 e18: e19:IFIH1:viral RNA:MAVS:TRAF3 e2: e20:TBK1{active} e21:IKK-i{active} e22:IRF-3{p}:IRF-3{p} e23:IRF-3{p}:IRF-7{p} e24:IRF-7{p}:IRF-7{p} e25:IRF-7{p}:IRF-7{p} e26:IRF-3{p}:IRF-7{p} e27:IRF-3{p}:IRF-3{p} e28:IFNAR1:IFNAR2 e29:IFNbeta:IFNAR1:IFNAR2 e3: e30:ISGF3 e31:ISGF3{active} e32:vIRF-1 e33:vIRF-1:p300 e34:E6 e35:E6:IRF-3 e36:NSP1 e37:E6:IRF-7 e38:NSP1:IRF-3 e39:NSP1:IRF-7 e4: e40:RTA e41:RTA:IRF-3 e42:RTA:IRF-7 e43:NS3/4A e44:protein remnants e45:TLR4:MD-2 e46:TLR4 oligomer:MD-2 e47:TLR4 oligomer:MD-2:CD14 e48:TLR4 oligomer:MD-2:CD14:LPS e49:TLR4 oligomer:MD-2:CD14:LPS:TRAM e5:viral RNA e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:DDX58:viral RNA e60: e61: e62: e63:TLR4 oligomer:MD-2:CD14:LPS:TRAM:TRIF e64:NAP1 e65:TLR4 oligomer:MD-2:CD14:LPS:TRAM:TRIF:TRAF3:NAP1:TBK1 e66: e67: e68: e69:Poly I:C e7: e70:TLR3:PolyI:C e71:dsRN:TLR3(2) e72:dsRNA:TLR3(2){p} e73:dsRNA:TLR3(2){p}:PI3K e74:TRIF{active} e75:c-Src e76:c-Src{active} e77:c-Src:TLR3 e78:RIP1:TRIF e79:TRAF6:TRIF e8: e80:CpG motif e81:TLR9:CpGmotif e82:ssRNA e83:TLR9:ssRNA e84:TLR9:CpG motif:MyD88 e85:TLR9:CpG motif:MyD88:IRF7 e86:TLR9:CpG motif:MyD88:IRF7:TRAF6 e87:Type I IFN genes e88:IRF-1:MyD88 e89:IRF-1 e9: e90:mRNA e91:NF-kappaB{active} e92:c-Jun{active} e93:c-Fos{active} e94:IRAK-4:IRAK-1:Ikk-alpha e95:TLR9:CpG motif:MyD88:IRF7{active}:TRAF6

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p8 p9
Model Detail
836.0, 1220.0
24.0, 24.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26 p27 p28 p71

p29

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
767.0, 1163.0
26.0, 26.0

IRF-1

--

G010384

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p68

true true true true

csml-variable:Double

m93359

10

false

infinite

0

unit false false false
TRANSFACG010384

--

Go back
909.0, 1197.0
22.0, 22.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
915.0, 1319.0
26.0, 26.0

CXCL10

--

G012252

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p23 p24 p25

--

true true true true

csml-variable:Double

m95041

10

false

infinite

0

unit false false false
TRANSFACG012252

--

Go back
1074.0, 1014.0
20.0, 20.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
421.0, 1433.0
22.0, 22.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m95

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
450.0, 1490.0
20.0, 20.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p72

true true true true

csml-variable:Double

m93

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
590.0, 638.0
20.5, 20.5

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p60

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
357.0, 685.0
21.0, 21.0

TRAF2

--

MO000000209

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6

true true true true

csml-variable:Double

m180

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
445.0, 701.0
21.5, 21.5

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p51 p65

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
608.0, 892.0
23.0, 23.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
286.0, 1450.0
20.0, 20.0

c-Fos

--

MO000000279

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74

true true true true

csml-variable:Double

m221

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
878.0, 294.0
20.0, 20.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

p68

p67

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
288.0, 1092.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p16 p34 p36 p38 p48 p57

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
558.0, 1078.0
20.0, 20.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p35 p37 p39 p64

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1124.0, 608.0
16.0, 16.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

p63 p67

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
527.0, 915.0
18.0, 18.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1270.0, 1218.0
20.0, 20.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p30

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
562.0, 106.0
19.0, 19.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p68

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
518.0, 522.0
20.0, 20.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
429.0, 765.0
22.0, 22.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10 p47

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
946.0, 174.0
20.0, 20.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
714.0, 1518.0
20.0, 20.0

RANKL

--

MO000018743

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71 p72 p73 p74

true true true true

csml-variable:Double

m3373

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000018743

--

Go back
326.0, 1006.0
20.0, 20.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12 p47 p56

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
690.0, 174.0
20.0, 20.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
911.0, 599.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p50 p59

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
677.0, 917.0
21.0, 21.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
722.0, 102.0
20.0, 20.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1253.0, 653.0
22.0, 22.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1109.0, 337.0
21.0, 21.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p55 p51 p60

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1049.0, 221.0
21.0, 21.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
902.0, 650.0
20.0, 20.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p52

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
332.0, 1252.0
24.0, 24.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p16 p48 p57

p17 p18

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
458.0, 1170.0
20.0, 20.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p18 p19

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
1082.0, 706.0
16.0, 16.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1077.0, 785.0
22.0, 22.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1127.0, 107.0
17.0, 17.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
470.0, 386.0
20.5, 20.5

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
414.0, 518.0
20.5, 20.5

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p4 p40

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
406.0, 294.0
19.0, 19.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
175.45161021007715, 135.00587645184328
1048.660136144555, 1522.6545176818925

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
183.3773998836472, 186.81687120628368
1024.822342807776, 1441.6368721008134

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
354.5, 630.0
19.64158561203891, 27.40686364470545

DDX58:viral RNA:MAVS

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p5 p9

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
558.5, 450.0
19.64158561203891, 27.40686364470545

IFIH1:viral RNA:MAVS

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p6 p10

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
374.0, 441.0
19.491712707182316, 21.657458563535908

IFIH1:viral RNA

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
595.0, 741.0
17.823529411764707, 29.705882352941178

DDX58:viral RNA:MAVS:TRAF2:TRAF5:FADD:RIP1

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p7

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
743.0, 705.0
17.823529411764707, 29.705882352941178

DDX58:viral RNA:MAVS:TRAF2:TRAF5:FADD:RIP1

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
756.0, 864.0
23.0, 23.0

IKK{active}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p8

--

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
360.0, 842.0
16.323529411764714, 27.205882352941188

DDX58:viral RNA:MAVS:TRAF3

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p11 p13

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
202.5531316377836, 195.13925085673716
1019.7505239373536, 1434.5022490673375

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
536.0, 862.0
16.323529411764714, 27.205882352941188

IFIH1:viral RNA:MAVS:TRAF3

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p12

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
175.45161021007715, 135.00587645184328
1048.660136144555, 1522.6545176818925

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
438.0, 1030.0
20.0, 20.0

TBK1{active}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p12 p56

p14 p15 p57

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
563.0, 995.0
18.0, 18.0

IKK-i{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p16

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
295.5, 1350.0
16.918513581069828, 20.716547242126317

IRF-3{p}:IRF-3{p}

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p22

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
390.5, 1304.0
18.959840026662224, 23.216130644892516

IRF-3{p}:IRF-7{p}

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p21

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
518.5, 1240.0
19.72737877020497, 24.15597400433261

IRF-7{p}:IRF-7{p}

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
710.5, 1296.0
19.72737877020497, 24.15597400433261

IRF-7{p}:IRF-7{p}

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p23 p26

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
738.5, 1340.0
18.959840026662224, 23.216130644892516

IRF-3{p}:IRF-7{p}

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p24 p27

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
735.5, 1386.0
16.918513581069828, 20.716547242126317

IRF-3{p}:IRF-3{p}

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p25 p28

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1185.5, 1143.0
20.976670554907518, 25.685719046825533

IFNAR1:IFNAR2

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p30

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1185.5, 1081.0
21.54340245916682, 30.060561570930442

IFNbeta:IFNAR1:IFNAR2

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
196.42481293296817, 155.97907917473435
1003.2285021974374, 1475.5819219820617

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
981.5, 986.0
20.162415122040738, 28.133602495870793

ISGF3

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
909.5, 1042.0
20.162415122040738, 28.133602495870793

ISGF3{active}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p32

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
746.0, 997.5
20.249547192594086, 12.487220768766353

vIRF-1

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
678.5, 1052.0
19.408931844692546, 23.766038993501084

vIRF-1:p300

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
781.0, 747.5
22.880000000000003, 17.16

E6

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34 p35

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
850.5, 816.0
18.86185635727379, 23.096150641559742

E6:IRF-3

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
624.5, 1005.0
14.125377339504928, 22.90601730730529

NSP1

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36 p37

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
842.5, 980.0
18.86185635727379, 23.096150641559742

E6:IRF-7

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
605.5, 1176.0
20.249958340276624, 24.795867355440762

NSP1:IRF-3

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
770.5, 1057.0
21.752374604232624, 26.635560739876688

NSP1:IRF-7

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
235.2252379703168, 192.68218393979345
929.1128806240757, 1407.3019027059904

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
318.0, 887.0
11.479887745556594, 26.492048643592142

RTA

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38 p39

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
291.5, 1009.0
17.35944009331778, 21.25645725712381

RTA:IRF-3

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
479.5, 817.0
17.35944009331778, 21.25645725712381

RTA:IRF-7

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
556.0, 340.5
23.980680217347555, 14.788086134030996

NS3/4A

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
674.0, 458.0
20.005743825387707, 19.338885697874787

protein remnants

--

e44

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
759.5, 164.0
17.046261784696338, 32.99276474457356

TLR4:MD-2

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p43

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
878.0, 163.0
20.294117647058822, 33.8235294117647

TLR4 oligomer:MD-2

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1058.0, 159.0
20.647058823529413, 34.411764705882355

TLR4 oligomer:MD-2:CD14

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p41

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1198.0, 151.0
20.647058823529413, 34.411764705882355

TLR4 oligomer:MD-2:CD14:LPS

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p45

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1182.0, 287.0
20.647058823529413, 34.411764705882355

TLR4 oligomer:MD-2:CD14:LPS:TRAM

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
299.0, 301.0
42.82006920415225, 22.837370242214533

viral RNA

--

e5

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p1 p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
645.1618605592676, 1108.7266413984862
421.19099615224627, 381.97395740436525

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
690.6536255068096, 1117.7788688861808
246.28300333669523, 370.2088457800008

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
650.652245983971, 1113.8248564357107
410.21022530283955, 371.777527329916

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
651.4365867589286, 1114.6091972106683
408.64154375292424, 370.2088457800008

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
645.1618605592676, 1108.7266413984862
421.19099615224627, 381.97395740436525

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
645.1618605592676, 1108.7266413984862
421.19099615224627, 381.97395740436525

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
652.229700377913, 1113.0229699726997
408.64154375292424, 370.2088457800008

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
952.623444342658, 1265.5947963900117
26.313699203948087, 23.82082243725833

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
883.601456146386, 1375.4025048840788
74.51237362097469, 67.45330664635617

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
645.1618605592676, 1108.7266413984862
421.19099615224627, 381.97395740436525

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
310.0, 477.0
19.491712707182316, 21.657458563535908

DDX58:viral RNA

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
744.4342084737386, 1278.4727117921923
13.33849997298184, 6.422240727731999

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
743.9887982039285, 1259.3200701903513
45.65455265555251, 82.17819477999447

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
763.1414398057707, 1312.7693025675833
7.1265643169642825, 7.126564316964291

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1186.0, 395.0
20.647058823529413, 34.411764705882355

TLR4 oligomer:MD-2:CD14:LPS:TRAM:TRIF

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p47

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1062.0, 512.5
20.8, 15.599999999999994

NAP1

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p47

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1186.0, 463.0
20.647058823529413, 34.411764705882355

TLR4 oligomer:MD-2:CD14:LPS:TRAM:TRIF:TRAF3:NAP1:TBK1

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
893.0, 563.0
221.07462120493773, 369.08220658790475

--

e66

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false true false

--

Go back
893.0, 563.0
221.07462120493773, 369.08220658790475

--

e67

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false true false

--

Go back
893.0, 563.0
221.07462120493773, 369.08220658790475

--

e68

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false true false

--

Go back
1248.0, 548.0
40.7232968881413, 23.07653490328007

Poly I:C

--

e69

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p49 p58

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
198.2819016110613, 148.711754509528
957.6800197995402, 1357.007850933667

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1018.5, 590.0
18.167726375794775, 35.163341372506025

TLR3:PolyI:C

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
902.5, 756.0
19.99683386102317, 24.485919013497757

dsRN:TLR3(2)

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p53

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
902.5, 852.0
19.99683386102317, 24.485919013497757

dsRNA:TLR3(2){p}

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1066.5, 855.0
18.31583776839787, 25.556982932648186

dsRNA:TLR3(2){p}:PI3K

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p55

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
797.0, 533.0
21.0, 21.0

TRIF{active}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p56

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
866.5, 354.0
11.891527470315959, 19.28355805997182

c-Src

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p58

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
770.5, 426.0
11.891527470315959, 19.28355805997182

c-Src{active}

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p58

p59

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
993.5, 759.0
20.511248125312445, 25.115814030994834

c-Src:TLR3

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
693.5, 239.0
20.83786035660723, 25.515747375437428

RIP1:TRIF

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
786.5, 284.0
19.61306448925179, 24.015997333777705

TRAF6:TRIF

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
201.70331265132393, 172.6616317913653
918.7138544889026, 1333.9725167178879

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1243.0, 718.5
50.034491907667814, 10.840806579994693

CpG motif

--

e80

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p61

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1026.5, 709.0
19.696996272747203, 38.123218592413934

TLR9:CpGmotif

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

p63

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1248.0, 795.5
48.84455163341372, 25.23635167726376

ssRNA

--

e82

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p62

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1049.5, 812.0
20.954395965796976, 40.55689541767156

TLR9:ssRNA

--

e83

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p62

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1073.5, 653.0
21.598641952651864, 30.137639933932835

TLR9:CpG motif:MyD88

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p64

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
910.0, 884.0
19.764705882352942, 32.94117647058824

TLR9:CpG motif:MyD88:IRF7

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
950.0, 912.0
19.764705882352942, 32.94117647058824

TLR9:CpG motif:MyD88:IRF7:TRAF6

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p66 p75

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
974.0, 1276.0
44.48096885813149, 23.72318339100346

Type I IFN genes

--

e87

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
926.0, 233.0
19.243093922651926, 21.381215469613267

IRF-1:MyD88

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p69

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
710.0, 1186.0
20.0, 20.0

IRF-1

--

e89

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

p70

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
210.82707542535698, 196.61150907320254
914.5194217970142, 1316.4778014244018

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
934.0, 1408.0
44.01384083044982, 23.474048442906575

mRNA

--

e90

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p70

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
526.0, 1410.0
20.0, 20.0

NF-kappaB{active}

--

e91

cso30:c:Protein

cso30:i:CC_CellComponent

--

p72

--

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
494.0, 1302.0
19.0, 19.0

c-Jun{active}

--

e92

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
358.0, 1426.0
20.0, 20.0

c-Fos{active}

--

e93

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

--

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
312.0, 574.0
16.764705882352942, 27.941176470588236

IRAK-4:IRAK-1:Ikk-alpha

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p75

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1030.0, 896.0
19.764705882352942, 32.94117647058824

TLR9:CpG motif:MyD88:IRF7{active}:TRAF6

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
310.0, 386.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m41844*m5*0.1

nodelay

--

true

0

false

PMID: 16979567,15208624,16116171 Recently, RIG-I and MDA5 have been identified as essential cytosolic receptors for intracellular viral RNAs and synthetic dsRNAs, mediating the TLR-independent induction of type I IFN genes

Go back
514.0, 770.0
19.0, 19.0

p9

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016963

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m12*m1872*0.1

nodelay

--

true

0

false

PMID: 16979567,16858409 Considering the fact that TRAF3 interacts with IPS-1 , TRAF3 probably provides a link between IPS-1 and TBK1 (Figure 2). PMID: 16979567 The conformational change promotes the interaction between the RIG-I and MDA5 CARDs and the CARD-containing adaptor protein IPS-1, which is located on the mitochondrial membrane, resulting in the activation of TBK1 via TRAF3 as well as IKK complex via FADD, RIP1 (not depicted), and TRAF6.

Go back
326.0, 938.0
19.0, 19.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 MO000019331

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m18*m3902*0.1

nodelay

--

true

0

false

PMID: 16979567 The conformational change promotes the interaction between the RIG-I and MDA5 CARDs and the CARD-containing adaptor protein IPS-1, which is located on the mitochondrial membrane, resulting in the activation of TBK1 via TRAF3 as well as IKK complex via FADD, RIP1 (not depicted), and TRAF6.

Go back
394.0, 926.0
19.0, 19.0

p11

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 MO000019331

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m20*m3902*0.1

nodelay

--

true

0

false

PMID: 16979567 The conformational change promotes the interaction between the RIG-I and MDA5 CARDs and the CARD-containing adaptor protein IPS-1, which is located on the mitochondrial membrane, resulting in the activation of TBK1 via TRAF3 as well as IKK complex via FADD, RIP1 (not depicted), and TRAF6.

Go back
438.0, 890.0
19.0, 19.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 MO000016608

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m18*m1599*0.1

nodelay

--

true

0

false

PMID: 16979567, 15210742 Inducible I¦ÊB kinase (IKKi; also known as IKK¦Å), which is structurally related to TBK1, was also shown to phosphorylate IRF3 and IRF7 in vitro; however, gene-targeting studies revealed that the contribution of IKKi to the cytosolic pathway is minor

Go back
342.0, 1142.0
19.0, 19.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m21*m977*0.1

nodelay

--

true

0

false

PMID: 16979567 Activated TBK1 induces the phosphorylation (P¡Ý) of IRF3 and IRF7, resulting in their homo- or heterodimerization.

Go back
526.0, 1130.0
19.0, 19.0

p14

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20 MO000007702

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m21*m980*0.1

nodelay

--

true

0

false

PMID: 16979567 Activated TBK1 induces the phosphorylation (P¡Ý) of IRF3 and IRF7, resulting in their homo- or heterodimerization.

Go back
502.0, 1042.0
19.0, 19.0

p13

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e21

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m977*m22*0.1

nodelay

--

true

0

false

PMID: 16979567, 15210742 Inducible I¦ÊB kinase (IKKi; also known as IKK¦Å), which is structurally related to TBK1, was also shown to phosphorylate IRF3 and IRF7 in vitro; however, gene-targeting studies revealed that the contribution of IKKi to the cytosolic pathway is minor

Go back
294.0, 1178.0
19.0, 19.0

p17

p17

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 16979567 Activated TBK1 induces the phosphorylation (P¡Ý) of IRF3 and IRF7, resulting in their homo- or heterodimerization. 18) PMID: 16979567 Phosphorylated IRF3 forms homodimers and induces IFN-¦Â and Cxcl10 genes

Go back
406.0, 1218.0
19.0, 19.0

p17

p18

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456 MO000041457

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m19324*m19325*0.1

nodelay

--

true

0

false

PMID: 16979567 Activated TBK1 induces the phosphorylation (P¡Ý) of IRF3 and IRF7, resulting in their homo- or heterodimerization.

Go back
518.0, 1178.0
19.0, 19.0

p17

p19

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041457

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 16979567 Activated TBK1 induces the phosphorylation (P¡Ý) of IRF3 and IRF7, resulting in their homo- or heterodimerization.

Go back
355.0, 547.0
17.0, 17.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000094908

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c11 : 1

m6*m68199*0.1

nodelay

--

true

0

false

PMID: 16979567 This CARD mediates CARD-CARD interactions with RIG-I and MDA5 and transmits downstream signaling

Go back
570.0, 1298.0
19.0, 19.0

p20

p20

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-beta.

Go back
474.0, 1342.0
19.0, 19.0

p20

p21

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-beta.

Go back
402.0, 1386.0
19.0, 19.0

p20

p22

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e22

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-beta. PMID: 16979567 The activated TBK1 mediates phosphorylation of serine residues in IRF3, rather than those in IRF7, inducing its dimerization and entry into the nucleus where it induces the transcription of the IFN-¦Â gene.

Go back
825.0, 1289.0
21.0, 21.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e25

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-¦Â

Go back
825.0, 1341.0
21.0, 21.0

p23

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-¦Â

Go back
865.0, 1381.0
21.0, 21.0

p23

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e27

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-¦Â 18) PMID: 16979567 Phosphorylated IRF3 forms homodimers and induces IFN-¦Â and Cxcl10 genes

Go back
750.0, 1222.0
19.0, 19.0

p23

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e25

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-¦Â

Go back
762.0, 1270.0
19.0, 19.0

p23

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-¦Â

Go back
786.0, 1322.0
19.0, 19.0

p23

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e27

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 16979567 These dimers then translocate to the nucleus and induce chemokines (including CXCL10) as well as small amounts of IFN-¦Â PMID: 16979567 The activated TBK1 mediates phosphorylation of serine residues in IRF3, rather than those in IRF7, inducing its dimerization and entry into the nucleus where it induces the transcription of the IFN-¦Â gene. PMID: 16979567 In a similar way to the TLR4 signaling, TLR3 activates the Trif- (TRAM is not involved), TBK1-, and IRF3-dependent pathway to induce IFN-¦Â gene

Go back
1090.0, 1218.0
19.0, 19.0

p29

p29

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 16979567 Secreted IFN-¦Â then stimulates type I IFN receptor (heterodimer of IFNAR1 and IFNAR2) in an autocrine and a paracrine fashion, leading to activation of ISGF3 (heterotrimer of STAT1, STAT2, and IRF9) and the transcription of IRF7 gene.

Go back
374.0, 350.0
19.0, 19.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000103999

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m5*m76904*0.1

nodelay

--

true

0

false

PMID: 16979567,15208624,16116171 Recently, RIG-I and MDA5 have been identified as essential cytosolic receptors for intracellular viral RNAs and synthetic dsRNAs, mediating the TLR-independent induction of type I IFN genes

Go back
1270.0, 1146.0
19.0, 19.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e28 MO000016660

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m29*m1636*0.1

nodelay

--

true

0

false

PMID: 16979567 Secreted IFN-¦Â then stimulates type I IFN receptor (heterodimer of IFNAR1 and IFNAR2) in an autocrine and a paracrine fashion, leading to activation of ISGF3 (heterotrimer of STAT1, STAT2, and IRF9) and the transcription of IRF7 gene.

Go back
966.0, 1054.0
19.0, 19.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e29 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m30*m31*0.1

nodelay

--

true

0

false

PMID: 16979567 Secreted IFN-¦Â then stimulates type I IFN receptor (heterodimer of IFNAR1 and IFNAR2) in an autocrine and a paracrine fashion, leading to activation of ISGF3 (heterotrimer of STAT1, STAT2, and IRF9) and the transcription of IRF7 gene.

Go back
837.0, 1145.0
19.0, 19.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 16979567 Secreted IFN-¦Â then stimulates type I IFN receptor (heterodimer of IFNAR1 and IFNAR2) in an autocrine and a paracrine fashion, leading to activation of ISGF3 (heterotrimer of STAT1, STAT2, and IRF9) and the transcription of IRF7 gene.

Go back
651.0, 959.0
17.0, 17.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 MO000019984

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m33*m4512*0.1

nodelay

--

true

0

false

PMID: 16979567,11314014 In addition, other viruses produce proteins that can interact with CBP/p300 and alter their interaction with IRFs, such as the vIRF-1 protein of human herpesvirus 8

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758.0, 818.0
19.0, 19.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000007694

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m35*m977*0.1

nodelay

--

true

0

false

PMID: 1679567,9649509,12186937,15664159 Some viruses produce a protein that directly binds to and prevents the transactivation ability of IRF3 or IRF7, including the E6 oncoprotein of the human papillomavirus, the NSP1 of the rotavirus , and the RTA protein of Kaposi's sarcoma-associated herpesvirus

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798.0, 874.0
19.0, 19.0

p34

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000007702

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m35*m980*0.1

nodelay

--

true

0

false

PMID: 1679567,9649509,12186937,15664159 Some viruses produce a protein that directly binds to and prevents the transactivation ability of IRF3 or IRF7, including the E6 oncoprotein of the human papillomavirus, the NSP1 of the rotavirus , and the RTA protein of Kaposi's sarcoma-associated herpesvirus

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622.0, 1110.0
19.0, 19.0

p34

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000007694

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m37*m977*0.1

nodelay

--

true

0

false

PMID: 1679567,9649509,12186937,15664159 Some viruses produce a protein that directly binds to and prevents the transactivation ability of IRF3 or IRF7, including the E6 oncoprotein of the human papillomavirus, the NSP1 of the rotavirus , and the RTA protein of Kaposi's sarcoma-associated herpesvirus

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590.0, 946.0
19.0, 19.0

p34

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007702 e36

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m980*m37*0.1

nodelay

--

true

0

false

PMID: 1679567,9649509,12186937,15664159 Some viruses produce a protein that directly binds to and prevents the transactivation ability of IRF3 or IRF7, including the E6 oncoprotein of the human papillomavirus, the NSP1 of the rotavirus , and the RTA protein of Kaposi's sarcoma-associated herpesvirus

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430.0, 958.0
19.0, 19.0

p34

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000007694

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m41*m977*0.1

nodelay

--

true

0

false

PMID: 1679567,9649509,12186937,15664159 Some viruses produce a protein that directly binds to and prevents the transactivation ability of IRF3 or IRF7, including the E6 oncoprotein of the human papillomavirus, the NSP1 of the rotavirus , and the RTA protein of Kaposi's sarcoma-associated herpesvirus

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486.0, 946.0
19.0, 19.0

p34

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000007702

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m41*m980*0.1

nodelay

--

true

0

false

PMID: 1679567,9649509,12186937,15664159 Some viruses produce a protein that directly binds to and prevents the transactivation ability of IRF3 or IRF7, including the E6 oncoprotein of the human papillomavirus, the NSP1 of the rotavirus , and the RTA protein of Kaposi's sarcoma-associated herpesvirus

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455.0, 443.0
17.0, 17.0

p2

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000094908

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c10 : 1
stoichiometry:c12 : 1

m13*m68199*0.1

nodelay

--

true

0

false

PMID: 16979567 This CARD mediates CARD-CARD interactions with RIG-I and MDA5 and transmits downstream signaling

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562.0, 406.0
19.0, 19.0

p40

p40

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e43 MO000094908

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m44*m68199*0.1

nodelay

--

true

0

false

PMID: 1679567,: 16177806 Interestingly, it has been shown that hepatitis C virus (HCV) nonstructural proteins 3 and 4A (NS3/4A) cleave IPS-1, thereby inhibiting the RIG-I- and MDA5-mediated activation of IRF3 and/or IRF7 during HCV infection

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1070.0, 106.0
19.0, 19.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 MO000042409

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m48*m157177*0.1

nodelay

--

true

0

false

PMID: 16979567 TLR4 is the only receptor that can induce type I IFN (IFN-¦Â, not IFN-¦Á) gene by recognizing nonnucleic acid ligands, such as lipopolysaccharide (LPS)

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779.0, 107.0
17.0, 17.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000022131

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m3961*m6438*0.1

nodelay

--

true

0

false

PMID: 16979567, 10359581 TLR4 is expressed on the plasma membrane, and the extracellular portion of TLR4 associates with MD-2, which is prerequisite for TLR4 oligomerization and downstream signaling upon the recognition of LPS

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847.0, 111.0
17.0, 17.0

p43

p43

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m46*0.1

nodelay

--

true

0

false

14) PMID: 16979567, 10359581 TLR4 is expressed on the plasma membrane, and the extracellular portion of TLR4 associates with MD-2, which is prerequisite for TLR4 oligomerization and downstream signaling upon the recognition of LPS

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938.0, 106.0
19.0, 19.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e46 MO000018132

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m47*m2828*0.1

nodelay

--

true

0

false

pMID: 1679567,15895089 The TLR4-MD-2 complex requires the aid of CD14, a high-affinity receptor for LPS, for the recognition of LPS and subsequent activation of the IFN-¦Â induction pathway

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1134.0, 234.0
19.0, 19.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 MO000041132

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m49*m19005*0.1

nodelay

--

true

0

false

PMID: 1679567,15210742,12872135,14556004 The receptor complex composed of CD14, TLR4, and MD-2 stimulates the signaling pathway through the adaptor proteins TRAM and Trif, which leads to the activation of TBK1

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1242.0, 326.0
19.0, 19.0

p45

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000041125

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m63*m18998*0.1

nodelay

--

true

0

false

PMID: 1679567,15210742,12872135,14556004 The receptor complex composed of CD14, TLR4, and MD-2 stimulates the signaling pathway through the adaptor proteins TRAM and Trif, which leads to the activation of TBK1

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1013.0, 353.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 e64 MO000019331 MO000016963

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c132 : 1
stoichiometry:c135 : 1

m64*m65*m3902*m1872*0.1

nodelay

--

true

0

false

PMID: 16979567 Trif associates with TBK1 through TRAF3 and NAP1, which mediates the phosphorylation of IRF3. Phosphorylated IRF3 forms homodimers and induces IFN-¦Â and Cxcl10 genes

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782.0, 706.0
19.0, 19.0

p48

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e65 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m66*m977*0.1

nodelay

--

true

0

false

17) PMID: 16979567 Trif associates with TBK1 through TRAF3 and NAP1, which mediates the phosphorylation of IRF3. Phosphorylated IRF3 forms homodimers and induces IFN-¦Â and Cxcl10 genes

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1107.0, 555.0
17.0, 17.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m3965*m70*0.1

nodelay

--

true

0

false

PMID: 16979567, 11607032,15711573,15558055 TLR3 recognizes poly(I:C) and probably viral dsRNAs derived from dsRNA viruses such as reovirus, or ssRNA viruses such as West Nile virus, respiratory syncytial virus, and EMCV

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445.0, 557.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000000209 MO000000212 MO000016899 MO000000065

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m11*m180*m183*m1814*m15*0.1

nodelay

--

true

0

false

PMID: 16979567,16127453,16153868 IPS-1 has been shown to interact with several signaling proteins, such as tumor necrosis factor receptor-associated factor 2 (TRAF2), TRAF6, Fas-associated protein with the death domain (FADD), and receptor interacting protein-1 (RIP1)

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975.0, 663.0
17.0, 17.0

p49

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 16979567, 11607032,15711573,15558055 TLR3 recognizes poly(I:C) and probably viral dsRNAs derived from dsRNA viruses such as reovirus, or ssRNA viruses such as West Nile virus, respiratory syncytial virus, and EMCV PMID: 16979567, 15961631 Crystallographic studies have shown that TLR3 directly binds to dsRNA and forms a dimer to activate downstream signaling

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665.0, 365.0
17.0, 17.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000041125

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c172 : 1

m183*m18998*0.1

nodelay

--

true

0

false

PMID: 16979567,14530355 It was first shown that TRAF6 interacts with the N-terminal region of Trif through its TRAF domain

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906.0, 702.0
19.0, 19.0

p52

p52

cso30:i:ME_Dimerization

cso30:i:CC_EndosomeLumen

--

MO000041446

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 16979567, 15961631 Crystallographic studies have shown that TLR3 directly binds to dsRNA and forms a dimer to activate downstream signaling

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903.0, 807.0
17.0, 17.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_EndosomeLumen

--

e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 16979567,15502848 The recognition of dsRNA by TLR3 results in the phosphorylation of two specific tyrosines (Tyr759 and Tyr858) within the cytoplasmic tail of TLR3 and the recruitment of phosphatidylinositol 3-kinase (PI3K) to the receptor

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1023.0, 983.0
17.0, 17.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000000030

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m73*m74*0.1

nodelay

--

true

0

false

PMID: 16979567, 15502848 The recognition of dsRNA by TLR3 results in the phosphorylation of two specific tyrosines (Tyr759 and Tyr858) within the cytoplasmic tail of TLR3 and the recruitment of phosphatidylinositol 3-kinase (PI3K) to the receptor

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789.0, 673.0
21.0, 21.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e73 MO000041125

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m75*m18998*0.1

nodelay

--

true

0

false

PMID: 16979567 In a similar way to the TLR4 signaling, TLR3 activates the Trif- (TRAM is not involved), TBK1-, and IRF3-dependent pathway to induce IFN-¦Â gene

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681.0, 649.0
21.0, 21.0

p55

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 MO000019331

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m76*m3902*0.1

nodelay

--

true

0

false

PMID: 16979567 In a similar way to the TLR4 signaling, TLR3 activates the Trif- (TRAM is not involved), TBK1-, and IRF3-dependent pathway to induce IFN-¦Â gene

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393.0, 1137.0
21.0, 21.0

p55

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m21*m977*0.1

nodelay

--

true

0

false

PMID: 16979567 In a similar way to the TLR4 signaling, TLR3 activates the Trif- (TRAM is not involved), TBK1-, and IRF3-dependent pathway to induce IFN-¦Â gene

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847.0, 427.0
17.0, 17.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e69 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m70*m77*0.1

nodelay

--

true

0

false

PMID: 16979567,16858407 It was also reported that the tyrosine kinase c-Src is activated by poly(I:C), associates with TLR3, and is essential for dsRNA-induced IRF3 activation

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904.0, 508.0
15.0, 15.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e76 MO000019398

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m78*m3965*0.1

nodelay

--

true

0

false

--

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650.0, 518.0
19.0, 19.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016899 MO000000065 MO000000209 MO000000212

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1

m12*m1814*m15*m180*m183*0.1

nodelay

--

true

0

false

PMID: 16979567,16127453,16153868 IPS-1 has been shown to interact with several signaling proteins, such as tumor necrosis factor receptor-associated factor 2 (TRAF2), TRAF6, Fas-associated protein with the death domain (FADD), and receptor interacting protein-1 (RIP1)

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717.0, 485.0
19.0, 19.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 MO000041125

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m15*m18998*0.1

nodelay

--

true

0

false

PMID: 16979567, 15064760 RIP1 interacts with Trif through the C-terminal RIP homotypic interaction motif (RHIM) of Trif

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1135.0, 743.0
18.0, 18.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m19828*m82*0.1

nodelay

--

true

0

false

) PMID: 16979567, 14563635, 12900525 DNA viruses such as herpes simplex virus (HSV) contain many unmethylated CpG motifs in their genome, which are recognized by TLR9 and induce robust type I IFN production in pDCs

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1136.0, 800.0
20.0, 20.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e82 MO000042126

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m84*m19940*0.1

nodelay

--

true

0

false

PMID: 16979567,14976261,14976262 Likewise, TLR7 signaling is essential for type I IFN induction in response to influenza virus or VSV infection by recognizing viral genomic ssRNA

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995.0, 535.0
17.0, 17.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e81

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m1572*m83*0.1

nodelay

--

true

0

false

PMID: 16979567 In contrast to TLR3- or TLR4-mediated Trif-dependent IFN gene induction, the TLR9 subfamily members exclusively utilize MyD88 as the signaling adaptor.

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671.0, 747.0
17.0, 17.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e84 MO000007702

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m86*m980*0.1

nodelay

--

true

0

false

PMID: 16979567,15492225,15361868 MyD88 directly interacts with IRF7 (not with IRF3) through its death domain

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885.0, 981.0
21.0, 21.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e85 MO000000212

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m87*m183*0.1

nodelay

--

true

0

false

PMID: 16979567,15492225, 15361868 IRF7 also interacts with TRAF6, another adaptor molecule functioning downstream of MyD88, and the overexpression of TRAF6 induces type I IFN genes through the activation of IRF7

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968.0, 1192.0
23.0, 23.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 16979567,15492225, 15361868 IRF7 also interacts with TRAF6, another adaptor molecule functioning downstream of MyD88, and the overexpression of TRAF6 induces type I IFN genes through the activation of IRF7

Go back
910.0, 398.0
19.0, 19.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007685 MO000016573

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m970*m1572*0.1

nodelay

--

true

0

false

PMID: 16979567,17018642 Similarly to IRF7, IRF1 directly interacts with MyD88 PMID: 16979567 Thus, the IRF1 induced by IFN-¦Ã binds to MyD88 and is modified by unidentified signaling molecule(s) to migrate into the nucleus and activate gene induction

Go back
809.0, 1037.0
19.0, 19.0

p68

p68

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010384 MO000016665

MO000007685

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c195 : 1
stoichiometry:c194 : 1

m93359*m1639*0.1

nodelay

--

true

0

false

PMID: 16979567 As opposed to IRF7, which is induced by type I IFN, IRF1 is strongly induced by IFN-¦Ã signaling.

Go back
717.0, 1085.0
19.0, 19.0

p69

p69

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e88

e89 MO000016573

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 16979567 Thus, the IRF1 induced by IFN-¦Ã binds to MyD88 and is modified by unidentified signaling molecule(s) to migrate into the nucleus and activate gene induction

Go back
593.0, 813.0
21.0, 21.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14 MO000000248

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m14*m207*0.1

nodelay

--

true

0

false

PMID: 16979567 The conformational change promotes the interaction between the RIG-I and MDA5 CARDs and the CARD-containing adaptor protein IPS-1, which is located on the mitochondrial membrane, resulting in the activation of TBK1 via TRAF3 as well as IKK complex via FADD, RIP1 (not depicted), and TRAF6.T

Go back
974.0, 1326.0
19.0, 19.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m91*0.1

nodelay

--

true

0

false

PMID: 16979567 Thus, the IRF1 induced by IFN-¦Ã binds to MyD88 and is modified by unidentified signaling molecule(s) to migrate into the nucleus and activate gene induction

Go back
798.0, 1434.0
19.0, 19.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000018743

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m3373*0.1

nodelay

--

true

0

false

PMID: 16979567,11961557 Furthermore, IFN-beta gene is induced by several nonviral agents such as the receptor activator of NF-¦ÊB ligand (RANKL), which activates NF-¦ÊB, c-JUN, and c-Fos, but not IRFs

Go back
553.0, 1481.0
21.0, 21.0

p72

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000018743 MO000000058

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m3373*m93*0.1

nodelay

--

true

0

false

PMID: 16979567,11961557 Furthermore, IFN-beta gene is induced by several nonviral agents such as the receptor activator of NF-¦ÊB ligand (RANKL), which activates NF-¦ÊB, c-JUN, and c-Fos, but not IRFs

Go back
593.0, 1433.0
21.0, 21.0

p72

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000018743 MO000000049

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m3373*m95*0.1

nodelay

--

true

0

false

PMID: 16979567,11961557 Furthermore, IFN-beta gene is induced by several nonviral agents such as the receptor activator of NF-¦ÊB ligand (RANKL), which activates NF-¦ÊB, c-JUN, and c-Fos, but not IRFs

Go back
361.0, 1501.0
21.0, 21.0

p72

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000018743 MO000000279

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1
stoichiometry:c211 : 1

m3373*m221*0.1

nodelay

--

true

0

false

PMID: 16979567,11961557 Furthermore, IFN-beta gene is induced by several nonviral agents such as the receptor activator of NF-¦ÊB ligand (RANKL), which activates NF-¦ÊB, c-JUN, and c-Fos, but not IRFs

Go back
629.0, 781.0
17.0, 17.0

p75

p75

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e94 e86

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m98*m88*0.1

nodelay

--

true

0

false

PMID: 16979567 Upon TLR7 or TLR9 (expressed in endosomes) stimulation, IRF7 interacting with MyD88 is activated by the IRAK4-IRAK1-IKKalpha kinase cascade.

Go back
685.0, 805.0
21.0, 21.0

p7

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e15 MO000000248

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m16*m207*0.1

nodelay

--

true

0

false

PMID: 16979567 The conformational change promotes the interaction between the RIG-I and MDA5 CARDs and the CARD-containing adaptor protein IPS-1, which is located on the mitochondrial membrane, resulting in the activation of TBK1 via TRAF3 as well as IKK complex via FADD, RIP1 (not depicted), and TRAF6.T

Go back
326.0, 766.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000016963

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m11*m1872*0.1

nodelay

--

true

0

false

PMID: 16979567,16858409 Considering the fact that TRAF3 interacts with IPS-1 , TRAF3 probably provides a link between IPS-1 and TBK1 (Figure 2). PMID: 16979567 The conformational change promotes the interaction between the RIG-I and MDA5 CARDs and the CARD-containing adaptor protein IPS-1, which is located on the mitochondrial membrane, resulting in the activation of TBK1 via TRAF3 as well as IKK complex via FADD, RIP1 (not depicted), and TRAF6.

Go back
337.0, 396.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.0, 467.05545334938284

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 1105.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.8230757390231, 1129.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 972.7651654101107

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.7186711919194, 972.0831832227035

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.0, 962.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 903.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 982.5593437103963

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.49824572467173, 972.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 902.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.84820007706753, 972.0136549791715

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.0, 564.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.4437601569802, 845.9876828256433

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 355.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
435.0, 428.82408634202505

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 420.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.0, 127.87324130794306

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.0, 113.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
775.4726885787005, 124.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.0, 130.52422684441223

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 128.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.0, 130.78684435314858

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.0, 453.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.97232952362, 132.94069110956326

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 120.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1071.0, 132.8356563460532

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1097.0, 116.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 120.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1157.1877316447983, 180.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.0, 233.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1151.0, 253.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1203.0, 310.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.0, 337.71145550379606

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.0, 582.1129463263483

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.7201327147384, 345.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1041.7110433666369, 369.1306830355181

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 376.60798172043934

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1029.3642751283176, 381.6426568101426

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 379.5070226088062

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1034.0, 371.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
807.9069755530128, 486.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.0, 728.956721108694

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0646224167636, 725.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.0, 567.7540106324884

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.0, 584.6085117976561

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1131.9976597161906, 561.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.1554175279994, 569.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.0, 617.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.9962446271163, 664.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.8870925171259, 663.3393175972478

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.0, 670.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.4563983243081, 721.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 780.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.0, 824.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
922.0, 875.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 586.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.8063839788742, 1001.2039430457753

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.0, 888.5204977687573

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.6603867297997, 695.4316191859757

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.5172413793103, 358.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 561.9898505738666

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
707.6568542494924, 554.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
346.0, 675.6568542494924

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.33361066981604, 670.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.0588143418104, 1050.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.0, 1109.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.1554175279993, 537.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.69794865315157, 1158.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.6582051289422, 440.3134161327013

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.7354436625493, 373.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 436.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 440.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.6296198833601, 530.9751851892278

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.0, 523.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
463.0, 388.7205150428243

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.9863236728672, 349.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 510.1382541438447

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.01449926937056, 577.8466608896548

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.4898078953818, 352.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.7601809954751, 272.96380090497735

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
682.0, 306.3033126100574

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.0, 720.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1160.7951295655569, 729.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.8053473145733, 731.7540106324884

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1163.9981103105913, 808.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1099.0, 799.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.7748008455096, 813.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1018.9726042969965, 552.9220899170605

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 578.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.4045888698995, 559.8757304490792

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 552.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.8170451815743, 670.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.0, 771.5797553643375

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 761.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.0537808947188, 917.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.0, 719.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 943.6568542494924

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
961.0, 945.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
982.0, 1215.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
578.0, 471.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.0, 314.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.7151676461435, 422.5979334380175

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.0, 261.9624572941336

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.0, 1063.664578975069

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
820.0, 321.96586917517885

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
574.0, 125.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.9072697173281, 254.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.4869005636044, 1104.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.0, 630.1075927862065

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 1201.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.0, 324.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 528.2855322440993

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.5298221281347, 1345.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.0, 1458.6568542494924

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.0, 1251.8601532282132

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.7988680525749, 1495.782598412017

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.0, 1493.576808097401

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.9207002305476, 1437.4477855878965

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.5538553641524, 1455.5876987549066

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
443.0, 1444.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.8363370752385, 1327.3725853226672

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.9907259786242, 1512.3850952278856

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.0, 544.141220603916

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 1467.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.43571594527896, 1453.9881256634476

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 594.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.3468955831091, 796.1659319782477

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 792.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.0, 537.9800969440827

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 537.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 542.3749326407672

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 771.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
607.6208448322876, 841.8340833560568

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.0, 827.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0432248920548, 735.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
630.0, 832.0545840621533

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 405.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 824.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.65170290363295, 657.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 776.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.0, 785.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.1086523438039, 477.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 776.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.0, 789.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.62816499953016, 869.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.0, 965.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0, 955.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
327.0, 499.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.3469669905552, 879.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 951.0881207287456

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.0, 945.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
376.0, 861.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
464.7206501967243, 905.0956050533966

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
457.0, 908.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.1734820130813, 1050.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.0, 1115.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.52632971131356, 1161.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 1050.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
379.28886338270684, 533.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.2399915200255, 1098.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.91023120718745, 1146.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.0, 1055.9210445530193

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.9614144909036, 1061.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.2179589656599, 1011.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.7312732965925, 1204.0765528038824

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.0, 1197.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 1236.5777087639997

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.8307845767519, 1189.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
403.41039280226477, 1237.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 452.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.0, 1181.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.0, 1197.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.0, 1263.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.0, 1308.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.0, 1320.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.0, 1352.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.0, 1363.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 1396.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 1301.5042584356408

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.0, 1303.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 324.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 1352.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.0, 1336.6994371546484

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 1392.2830085864284

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
886.0, 1351.0621504188273

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.0, 1248.0765528038824

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
769.0, 1232.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 1296.5894663844042

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.0, 1244.2065767803003

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 1347.1794038879277

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
801.0, 1251.0813141194785

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.9488441556671, 313.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 1228.125968632795

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1109.0, 1228.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1206.0, 1156.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1280.0, 1173.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1213.509867769654, 1108.6499055497527

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.9180125442983, 1066.142399819824

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.9402850002907, 1014.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.923938185422, 1058.1005469701975

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.7863138598775, 1070.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.0, 1162.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.0, 369.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.4985052662139, 973.7879058041051

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.6499055497528, 938.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 976.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
773.5726594108631, 765.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 838.0635862119411

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 828.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.0, 765.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 897.1811873607643

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 893.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0, 1028.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back