1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17046325.csml convertedTime:2009.07.01.10:58

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title IRAK-4--a shared NF-kappaB activator in innate and acquired immunity.
Authors Suzuki N, Saito T.
Affiliation Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. nobu@rcai.riken.jp
Abstract The human body is protected against external pathogens by two immune systems:innate and acquired immunities. Whereas innate immunity exhibits immediateresponses to external pathogens by recognizing pathogen-associated molecularpatterns (PAMPs), adaptive immunity uses T cells to recognize and defend againstpathogens by developing effector cells, antibodies and memory cells. Althougheach system seems to possess distinct activation mechanisms, interleukin-1receptor-associated kinase (IRAK)-4 is essential for NF-kappaB activation inToll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. Thisimplies possible crosstalk between innate and acquired immunities, andevolutionary development that resulted in the use of innate signaling moleculesby the acquired immune system. Here, we discuss the impact of theseevolutionarily conserved molecules on innate and acquired immunity, and theirpotential as drug targets for the simultaneous modulation of both immunities.
PMID 17046325
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010453:IFN-gamma G011345:IL10 MO000000023:JNK MO000000058:NF-kappaB {activated} MO000000065:RIP1 MO000000077:MAPKs MO000000103:PMA MO000000133:PLCbeta MO000000138:Lck MO000000212:TRAF6 MO000000213:IRAK-1 MO000000214:IL-1 MO000000265:chemokines MO000000289:TNF-alpha MO000000332:IP3 MO000007384:IL-6 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016660:IFNbeta MO000016665:IFNgamma MO000016724:calcineurin MO000016882:LPS MO000016963:TRAF3 MO000017142:PDK1 MO000017151:Bcl-xL MO000017212:NF-AT MO000017214:CD25 MO000017247:IL-10 MO000017264:IL-8 MO000017433:PKCtheta MO000017617:PLCgamma1 MO000017704:PLCgamma2 MO000017772:ZAP-70 MO000017777:TCR MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000022125:TAB2 MO000022136:Ubc13 MO000022185:flagellin MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 e1: e10: e100:Ca e101:cyclosporine e102:FK506 e103:IkappaB: NFkappaB e104:Triacyl lipopeptide e105:Diacyl lipopeptide e106:IkappaB {p}: NFkappaB e107:IkappaB {ub}: NFkappaB e11: e12: e13:Uev1A e14:TLR ligand e15:TLR ligand: TLR e16:TLR ligand: TLR: MyD88 e17:IL1 e18:CpG DNA e2: e21:TLR2: TLR1: Triacyl lipopeptide e22:TLR2: TLR6: Diacyl lipopeptide e23:TLR2: TLR6: Diacyl lipopeptide: TIRAP e24:TLR2: TLR1: Triacyl lipopeptide: TIRAP e25:TLR2: TLR1: Triacyl lipopeptide: TIRAP: MyD88 e26:TLR2: TLR6:Diacyl lipopeptide: TIRAP: MyD88 e27:R-848 e28:R-848: TLR7 e29:R-848: TLR8 e3: e30:CpG DNA: TLR9 e31:flagellin: TLR5 e32:IL8 e33:flagellin: TLR5: MyD88 e34:R-848: TLR7: MyD88 e35:R-848: TLR8: MyD88 e36:CpG DNA: TLR9: MyD88 e37:R-848: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7 e38:R-848: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7 e39:CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7 e4: e40:LPS: TLR4 e41:LPS: TLR4: TIRAP e42:LPS: TLR4: TRAM e43:LPS: TLR4: TIRAP: MyD88 e44:LPS: TLR4: TRAM: TRIF e45:LPS: TLR4: TRAM: TRIF: RIP1 e46:poly I:C: TLR3 e47:poly I:C: TLR3: TRIF e48:poly I:C e49:poly I:C: TLR3: TRIF: RIP1 e5:IKK-alpha:IKK-beta:IKK-gamma e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5 e64:IRAK-1{p}: TRAF6 e65:TLR ligand: TLR: MyD88: IRAK-1{p}: IRAK-4: TRAF6: IRF-5 e66:TLR ligand: TLR: MyD88: IRAK-4: IRF-5 e67:IRAK-1{p}: TRAF6: TAK1: TAB1: TAB2: Ubc13: Uev1A e68:IRAK-1{p}: TRAF6: TAK1 {activated}: TAB1: TAB2: Ubc13: Uev1A e69:IKK-alpha:IKK-beta:IKK-gamma {p} e7: e71:JNK {activated} e72:MAPKs {activated} e74:protein ramnents e75:NF-kappaB {nucleus} e76:TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5 {activated} e77:IFNalpha e78:antigen-MHC complex e79:IFNalpha e8: e80:antigen-MHC complex: TCR: CD3zeta e81:TCR: CD3zeta e82:antigen-MHC complex: TCR: CD3zeta {p} e83:antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70 e84:LAT: SLP-76 e85:LAT {p}: SLP-76 {p} e86:LAT {p}: SLP-76 {p}: PLCgamma1 e87:PKCtheta {p} e88:antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70: IRAK-4 e89:calcineurin {activated} e9: e90:NF-AT {activated} e91:CBM complex e92:CBM complex: PKCtheta {p} e93:PMA: TCR e94:PLCbeta {activated} e95:PLCgamma2 {activated} e96:CD25 e97:Bcl-xL e98:cytokines e99:chemokines

Process

p1 p10 p100 p101 p102 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
1008.0, 1196.0
32.0, 32.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p81 p82 p83 p84 p85

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
709.0, 1149.0
30.0, 30.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p91 p92 p93 p94 p95

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
658.0, 1190.0
27.0, 27.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p86 p87 p88 p89 p90

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
598.0, 1306.0
28.0, 28.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p64 p65 p66 p73 p74 p75

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
746.0, 1418.0
28.0, 28.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p63 p69 p70

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
1138.0, 678.0
28.0, 28.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1127.0, 999.0
34.0, 34.0

NF-kappaB {activated}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41 p102

p42

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
847.0, 275.0
26.0, 26.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p30

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1279.0, 623.0
34.0, 34.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1485.0, 1389.0
30.0, 30.0

PMA

--

MO000000103

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m117377

10

false

infinite

0

unit false false false
TRANSPATHMO000000103

--

Go back
1134.0, 1634.0
28.0, 28.0

PLCbeta

--

MO000000133

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m120

10

false

infinite

0

unit false false false
TRANSPATHMO000000133

--

Go back
1363.0, 871.0
26.0, 26.0

Lck

--

MO000000138

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m123

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000138

--

Go back
705.0, 537.0
30.0, 30.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21 p31

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
707.0, 451.0
30.0, 30.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21 p31

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
782.0, 898.0
28.0, 28.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p96 p97 p98 p99 p100

--

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1046.0, 1546.0
28.0, 28.0

chemokines

--

MO000000265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p72

--

true true true true

csml-variable:Double

m211

10

false

infinite

0

unit false false false
TRANSPATHMO000000265

--

Go back
401.0, 1013.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p86 p87 p88 p89 p90

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1238.0, 1170.0
28.0, 28.0

IP3

--

MO000000332

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m290230

10

false

infinite

0

unit false false false
TRANSPATHMO000000332

--

Go back
586.0, 946.0
28.0, 28.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p91 p92 p93 p94 p95

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
706.0, 578.0
32.0, 32.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21 p31

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
704.0, 616.0
36.0, 36.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
981.0, 337.0
34.0, 34.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p9 p10 p15 p16 p17 p18 p25

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1077.0, 393.0
38.0, 38.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1087.0, 439.0
25.0, 25.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
1063.0, 1019.0
25.5, 25.5

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p81 p82 p83 p84 p85

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
426.0, 1326.0
28.5, 28.5

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64 p65 p66 p73 p74 p75

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1237.0, 1409.0
30.0, 30.0

calcineurin

--

MO000016724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m1676

10

false

infinite

0

unit false false false
TRANSPATHMO000016724

--

Go back
1037.0, 45.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
708.0, 664.0
28.0, 28.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1195.0, 1295.0
26.0, 26.0

PDK1

--

MO000017142

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m2019

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017142

--

Go back
789.0, 1613.0
30.0, 30.0

Bcl-xL

--

MO000017151

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61 p6

--

true true true true

csml-variable:Double

m2028

10

false

infinite

0

unit false false false
InterProIPR004725
TRANSPATHMO000017151

--

Go back
1207.0, 1551.0
26.0, 26.0

NF-AT

--

MO000017212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m2078

10

false

infinite

0

unit false false false
TRANSPATHMO000017212

--

Go back
855.0, 1627.0
34.0, 34.0

CD25

--

MO000017214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60 p5

--

true true true true

csml-variable:Double

m2080

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017214

--

Go back
592.0, 1524.0
32.0, 32.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63 p69 p70

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
497.0, 1461.0
30.0, 30.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62 p67 p68

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
1220.0, 1240.0
31.0, 31.0

PKCtheta

--

MO000017433

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p57

true true true true

csml-variable:Double

m2259

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017433

--

Go back
1249.0, 1117.0
29.0, 29.0

PLCgamma1

--

MO000017617

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p50

true true true true

csml-variable:Double

m2395

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000017617

--

Go back
1286.0, 1590.0
28.0, 28.0

PLCgamma2

--

MO000017704

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m2464

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000017704

--

Go back
1289.0, 941.0
30.0, 30.0

ZAP-70

--

MO000017772

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m2529

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017772

--

Go back
1364.0, 1388.0
32.0, 32.0

TCR

--

MO000017777

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m2534

10

false

infinite

0

unit false false false
TRANSPATHMO000017777

--

Go back
898.0, 1546.0
28.0, 28.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p71

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
1040.0, 220.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1313.0, 185.0
30.0, 30.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
409.0, 233.0
26.0, 26.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
353.0, 204.0
30.0, 30.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
833.0, 225.0
26.0, 26.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
354.0, 1022.0
28.0, 28.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
353.0, 245.0
26.0, 26.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
990.0, 510.0
28.0, 28.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false

--

Go back
1055.0, 531.0
26.0, 26.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
250.0, 1070.0
28.0, 28.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
562.0, 334.0
28.0, 28.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8 p24

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
707.0, 491.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21 p31 p51

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
897.0, 297.0
30.5, 30.5

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p29

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1003.0, 279.0
30.0, 30.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
407.0, 699.0
30.0, 30.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
408.0, 788.0
28.0, 28.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
408.0, 664.0
28.0, 28.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
330.6406697996498, 178.16483324714721
1084.595975615355, 1574.833356593491

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
350.3799188091149, 293.598268986417
979.8010303504183, 1378.3045447716902

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1281.875, 1441.5
27.818987431153786, 28.29049569269877

Ca

--

e100

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p101

p53

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1146.5, 1472.25
43.057190916736765, 24.399074852817492

cyclosporine

--

e101

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1144.5, 1505.25
38.313708999158955, 21.711101766190072

FK506

--

e102

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
990.5, 636.0
26.89651724712548, 32.934510914847536

IkappaB: NFkappaB

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p37

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
346.0, 83.0
44.58368376787216, 25.26408746846089

Triacyl lipopeptide

--

e104

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
198.0, 207.0
44.48275862068966, 25.206896551724135

Diacyl lipopeptide

--

e105

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1060.75, 690.0
29.840109981669727, 36.5389101816364

IkappaB {p}: NFkappaB

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p40

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1139.75, 752.0
33.04090984835861, 40.4582569571738

IkappaB {ub}: NFkappaB

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41 p102

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
420.0, 485.81432878842503
244.57929569719107, 408.3230614605649

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
412.0, 485.81432878842503
244.57929569719107, 408.3230614605649

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
1103.0, 527.5
34.400000000000006, 25.799999999999997

Uev1A

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1370.5, 76.375
34.70123022847099, 22.55579964850615

TLR ligand

--

e14

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1372.625, 181.5
29.8993084485919, 36.61139810031661

TLR ligand: TLR

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1359.875, 229.5
32.25, 45.0

TLR ligand: TLR: MyD88

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p31

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
792.0, 1112.0
32.0, 32.0

IL1

--

e17

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p96 p97 p98 p99 p100

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSFACG011140

--

Go back
247.5, 878.125
45.0, 15.75

CpG DNA

--

e18

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
330.6406697996498, 178.16483324714721
1084.595975615355, 1574.833356593491

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
489.875, 191.5
32.25, 45.0

TLR2: TLR1: Triacyl lipopeptide

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p8

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
345.875, 319.5
32.25, 45.0

TLR2: TLR6: Diacyl lipopeptide

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p7

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
345.875, 367.5
32.25, 45.0

TLR2: TLR6: Diacyl lipopeptide: TIRAP

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p10

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
541.875, 179.5
32.25, 45.0

TLR2: TLR1: Triacyl lipopeptide: TIRAP

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p8

p9

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
598.875, 166.5
42.122086621398424, 58.7750045879978

TLR2: TLR1: Triacyl lipopeptide: TIRAP: MyD88

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p60 p61 p87 p92 p97

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
359.875, 417.5
32.25, 45.0

TLR2: TLR6:Diacyl lipopeptide: TIRAP: MyD88

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p86 p91 p96 p5 p6

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
239.5, 657.25
45.0, 25.5

R-848

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p11 p12

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
410.625, 619.5
30.34023496083986, 37.15130811531411

R-848: TLR7

--

e28

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

p16

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
399.625, 743.5
29.450216630561577, 36.06148975170805

R-848: TLR8

--

e29

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p12

p17

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
352.33258931195667, 199.85675275945417
1041.212136590741, 1531.4495175688771

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
436.625, 861.5
27.229253457757043, 33.341943009498415

CpG DNA: TLR9

--

e30

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p13

p18

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
353.625, 1061.5
29.49920846525579, 36.12147975337444

flagellin: TLR5

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p15

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
686.0, 1402.0
27.0, 27.0

IL8

--

e32

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p62 p67 p68

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
Affymetrix1369_s_at
EnsemblENSG00000169429
HGNCIL8
OMIM146930
ProteomeHumanPSD/IL8
RefSeqNM_000584
TRANSFACG000317
UnigeneHs.551925

--

Go back
351.875, 1113.5
32.25, 45.0

flagellin: TLR5: MyD88

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p63 p65 p67

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
401.875, 567.5
32.25, 45.0

R-848: TLR7: MyD88

--

e34

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p16

p19

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
409.875, 515.5
32.25, 45.0

R-848: TLR8: MyD88

--

e35

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p17

p20

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
489.875, 851.5
32.25, 45.0

CpG DNA: TLR9: MyD88

--

e36

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p18

p21

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
517.5, 482.0
36.56854468709856, 51.02587630757937

R-848: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7

--

e37

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p20

p64 p69 p77 p82

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
579.875, 509.5
32.25, 45.0

R-848: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7

--

e38

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p19

p66 p70 p78 p83

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
587.875, 805.5
32.25, 45.0

CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7

--

e39

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p21

p75 p76 p81 p90 p94 p99

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
392.46264040972477, 237.81761190599155
960.9520343952047, 1455.5277992758024

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1100.625, 189.5
30.968963506082318, 37.9211798033661

LPS: TLR4

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p23 p24 p73 p80 p85 p88 p95 p100

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1159.875, 185.5
32.25, 45.0

LPS: TLR4: TIRAP

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p25

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
969.875, 179.5
32.25, 45.0

LPS: TLR4: TRAM

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p23

p26

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1221.875, 178.5
36.10887318774087, 50.38447421545238

LPS: TLR4: TIRAP: MyD88

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
921.875, 195.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

p27

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
877.875, 207.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: RIP1

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
773.875, 215.5
32.25, 45.0

poly I:C: TLR3

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
705.875, 183.5
32.25, 45.0

poly I:C: TLR3: TRIF

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p30

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
767.5, 65.25
45.0, 25.5

poly I:C

--

e48

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p28

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
652.875, 156.5
39.15493668563039, 54.63479537529822

poly I:C: TLR3: TRIF: RIP1

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p74 p79 p84 p89 p93 p98

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1149.0, 581.0
38.0, 38.0

IKK-alpha:IKK-beta:IKK-gamma

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
544.6090192500199, 1024.5977609387376
549.70690818176, 498.52376961735075

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
603.981459984735, 1036.4120495391035
321.4301101844932, 483.1688280480275

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
551.7746586490371, 1031.2515689521108
535.3756293837262, 485.216153590604

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
552.7983214203255, 1032.2752317233983
533.3283038411497, 483.1688280480275

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
544.6090192500199, 1024.5977609387376
549.70690818176, 498.52376961735075

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
544.6090192500199, 1024.5977609387376
549.70690818176, 498.52376961735075

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
552.7983214203255, 1032.2752317233983
533.3283038411497, 483.1688280480275

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
945.8848255949928, 1229.330315196377
34.342667256349955, 31.089151411011557

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
855.8025017216322, 1372.6431031767243
97.24796327237841, 88.03499833078476

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
544.6090192500199, 1024.5977609387376
549.70690818176, 498.52376961735075

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
412.0, 485.81432878842503
244.57929569719107, 408.3230614605649

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
674.1718445205835, 1246.1376048208679
17.408410072659706, 8.381827072021347

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
673.5905284323321, 1221.1410130260701
59.58489904573736, 107.25281828232711

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
698.5871202271297, 1290.8989436162026
9.30105741201753, 9.301057412017533

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1356.875, 281.5
37.72660121123142, 52.64176913195082

TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p32 p43 p71 p72

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1209.625, 434.5
28.870479920013334, 35.351608065322445

IRAK-1{p}: TRAF6

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1353.875, 348.5
44.7104514589833, 62.3866764543953

TLR ligand: TLR: MyD88: IRAK-1{p}: IRAK-4: TRAF6: IRF-5

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p33

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1353.875, 426.5
36.97692237107726, 51.595705634061304

TLR ligand: TLR: MyD88: IRAK-4: IRF-5

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1159.875, 501.5
32.25, 45.0

IRAK-1{p}: TRAF6: TAK1: TAB1: TAB2: Ubc13: Uev1A

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1279.875, 569.5
32.25, 45.0

IRAK-1{p}: TRAF6: TAK1 {activated}: TAB1: TAB2: Ubc13: Uev1A

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p38 p39 p36

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1151.875, 625.5
32.25, 45.0

IKK-alpha:IKK-beta:IKK-gamma {p}

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
343.921463903466, 184.07105854611265
991.306492019388, 1404.6556934887235

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1142.0, 718.0
28.0, 28.0

JNK {activated}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1283.0, 675.0
34.0, 34.0

MAPKs {activated}

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1278.5, 759.25
26.734635267087874, 25.843480758184946

protein ramnents

--

e74

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p41 p102

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1007.0, 1311.0
34.0, 34.0

NF-kappaB {nucleus}

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

--

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1359.875, 485.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5 {activated}

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
907.0, 879.0
25.0, 25.0

IFNalpha

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76 p77 p78 p79 p80

--

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
1480.625, 769.5
29.89114314280953, 36.60139976670555

antigen-MHC complex

--

e78

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p44

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
926.0, 1158.0
28.0, 28.0

IFNalpha

--

e79

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p76 p77 p78 p79 p80

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSFACG010227

--

Go back
347.4630089978168, 208.8618742065693
950.9721299747237, 1380.8115327232974

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1367.875, 821.5
32.25, 45.0

antigen-MHC complex: TCR: CD3zeta

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

p45

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1357.625, 762.5
29.319571738043653, 35.90151641393101

TCR: CD3zeta

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p44

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1359.875, 909.5
32.25, 45.0

antigen-MHC complex: TCR: CD3zeta {p}

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p45

p46

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1355.875, 988.5
39.75467975775371, 55.471646173609834

antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70

--

e83

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p46

p47 p51

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1229.625, 998.5
28.478545242459585, 34.871688051991335

LAT: SLP-76

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p47

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1230.625, 1047.5
27.629353441093148, 33.83186135644059

LAT {p}: SLP-76 {p}

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1288.875, 1099.5
29.472242613323544, 41.12405946045146

LAT {p}: SLP-76 {p}: PLCgamma1

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p49 p52 p101

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1224.5, 1329.125
38.760000000000005, 29.069999999999997

PKCtheta {p}

--

e87

cso30:c:Protein

cso30:i:CC_Cytosol

--

p50 p57

p54

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1356.875, 1228.5
39.21017617911543, 54.7118737383006

antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70: IRAK-4

--

e88

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p51

p50

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1213.0, 1445.0
30.0, 30.0

calcineurin {activated}

--

e89

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p53

true true true true

csml-variable:Double

m93

10

false

infinite

0

unit false false false
TRANSPATHMO000016724

--

Go back
356.9071292494194, 233.65268986702586
946.6304205604687, 1362.7025354716945

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1283.0, 1539.0
26.0, 26.0

NF-AT {activated}

--

e90

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

--

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
TRANSPATHMO000017212

--

Go back
1075.875, 881.5
32.25, 45.0

CBM complex

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p54

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1099.875, 805.5
32.25, 45.0

CBM complex: PKCtheta {p}

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p102

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1361.625, 1326.5
29.148100316613892, 35.69155140809865

PMA: TCR

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

p57

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1230.0, 1582.0
28.0, 28.0

PLCbeta {activated}

--

e94

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58

p59

true true true true

csml-variable:Double

m98

10

false

infinite

0

unit false false false
TRANSPATHMO000000133

--

Go back
1282.0, 1634.0
28.0, 28.0

PLCgamma2 {activated}

--

e95

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59

--

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000017704

--

Go back
852.5, 1446.0
38.8235294117647, 20.705882352941174

CD25

--

e96

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p60 p5

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
779.5, 1481.0
40.38062283737024, 21.536332179930795

Bcl-xL

--

e97

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p61 p6

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
949.5, 1434.0
36.43598615916956, 19.432525951557093

cytokines

--

e98

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p71

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
993.5, 1390.0
37.214532871972324, 19.847750865051903

chemokines

--

e99

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

--

p72

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
1376.0, 128.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 MO000019395

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m16*m3962*0.1

nodelay

--

true

0

false

PMID: 17046325 Following ligand stimulation, TLRs associate with adaptor proteins such as myeloid differentiation primary response gene (MyD)88 through interaction between the individual Toll and interleukin-1 receptor (TIR) domains.

Go back
425.0, 389.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m1572*m27*0.1

nodelay

--

true

0

false

PMID: 17046325 After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.

Go back
816.5, 988.5
19.0, 19.0

p100

p100

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17 e40

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c313 : 1
stoichiometry:c293 : 1

m19*m44*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
1492.0, 1444.0
23.0, 23.0

p101

p101

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e86

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c320 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCtheta co-operates with the CBM complex to culminate in NF-kappaB activation.

Go back
1192.0, 788.0
23.0, 23.0

p41

p102

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e92 e107

e74 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c323 : 1

m96*m111*0.1

nodelay

--

true

0

false

PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKC¦È co-operates with the CBM complex to culminate in NF-kappaB activation.

Go back
316.0, 640.0
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e27 MO000042126

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m31*m19940*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
316.0, 680.0
27.0, 27.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e27 MO000042007

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m31*m19823*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
332.0, 872.0
28.0, 28.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000042012 e18

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m19828*m22*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

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251.0, 1007.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

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431.0, 1123.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m1572*m35*0.1

nodelay

--

true

0

false

PMID: 17046325 Following TLR5 stimulation, MyD88 but not TIRAP is recruited into the receptor complex.

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486.0, 550.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e28

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m1572*m32*0.1

nodelay

--

true

0

false

PMID: 17046325 Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.

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480.0, 716.0
27.0, 27.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e29

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m1572*m33*0.1

nodelay

--

true

0

false

PMID: 17046325 Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.

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479.0, 767.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e30 MO000016573

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m34*m1572*0.1

nodelay

--

true

0

false

PMID: 17046325 Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.

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522.0, 610.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000000213 MO000039077 MO000000212 MO000007700 MO000007702 MO000016963 e34

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c65 : 1
stoichiometry:c68 : 1
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c77 : 1

m184*m17258*m183*m979*m980*m1872*m38*0.1

nodelay

--

true

0

false

PMID: 17046325 Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.

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1118.0, 274.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000016573 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m1572*m17*0.1

nodelay

--

true

0

false

PMID: 17046325 Following ligand stimulation, TLRs associate with adaptor proteins such as myeloid differentiation primary response gene (MyD)88 through interaction between the individual Toll and interleukin-1 receptor (TIR) domains.

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570.0, 562.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000000213 MO000039077 MO000000212 MO000007700 MO000007702 MO000016963 e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c58 : 1
stoichiometry:c62 : 1
stoichiometry:c64 : 1
stoichiometry:c67 : 1
stoichiometry:c70 : 1
stoichiometry:c74 : 1
stoichiometry:c76 : 1

m184*m17258*m183*m979*m980*m1872*m39*0.1

nodelay

--

true

0

false

PMID: 17046325 Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.

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528.0, 772.0
27.0, 27.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000000213 MO000039077 MO000000212 MO000007700 MO000007702 MO000016963 e36

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c60 : 1
stoichiometry:c63 : 1
stoichiometry:c66 : 1
stoichiometry:c69 : 1
stoichiometry:c72 : 1
stoichiometry:c75 : 1
stoichiometry:c78 : 1

m184*m17258*m183*m979*m980*m1872*m40*0.1

nodelay

--

true

0

false

PMID: 17046325 Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.

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1041.0, 93.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

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1004.0, 120.0
27.0, 27.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 MO000041132

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m44*m19005*0.1

nodelay

--

true

0

false

PMID: 17046325 However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon ¦Â (TRIF)-related adaptor molecule (TRAM)?TRIF?RIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAP?MyD88 signaling pathway.

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1103.0, 99.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 MO000022528

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c88 : 1
stoichiometry:c82 : 1

m44*m6810*0.1

nodelay

--

true

0

false

PMID: 17046325 However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon ¦Â (TRIF)-related adaptor molecule (TRAM)?TRIF?RIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAP?MyD88 signaling pathway.

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1227.0, 115.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000016573

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m45*m1572*0.1

nodelay

--

true

0

false

PMID: 17046325 However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon ¦Â (TRIF)-related adaptor molecule (TRAM)?TRIF?RIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAP?MyD88 signaling pathway.

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925.0, 121.0
25.0, 25.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 MO000041125

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m46*m18998*0.1

nodelay

--

true

0

false

PMID: 17046325 However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon ¦Â (TRIF)-related adaptor molecule (TRAM)?TRIF?RIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAP?MyD88 signaling pathway.

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880.0, 124.0
27.0, 27.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000065 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m15*m48*0.1

nodelay

--

true

0

false

PMID: 17046325 However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon ¦Â (TRIF)-related adaptor molecule (TRAM)?TRIF?RIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAP?MyD88 signaling pathway.

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777.0, 137.0
25.0, 25.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 e48

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m3965*m65*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

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730.0, 298.0
27.0, 27.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 MO000041125

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m63*m18998*0.1

nodelay

--

true

0

false

PMID: 17046325 TLR3 signaling, only TRIF and RIP1 are recruited. The TRAM?TRIF?RIP1 signaling pathway is MyD88-independent but IRAK-4-dependent.

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357.0, 133.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000019396 e104

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c14 : 1
stoichiometry:c321 : 1

m3964*m3963*m108*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

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783.0, 275.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 e47

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m15*m64*0.1

nodelay

--

true

0

false

PMID: 17046325 TLR3 signaling, only TRIF and RIP1 are recruited. The TRAM?TRIF?RIP1 signaling pathway is MyD88-independent but IRAK-4-dependent.

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986.0, 394.0
27.0, 27.0

p31

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000213 MO000039077 MO000007700 MO000000212 e16

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c205 : 1
stoichiometry:c110 : 1

m184*m17258*m979*m183*m18*0.1

nodelay

--

true

0

false

PMID: 17046325 IRAK-4, IRAK-1, IRF5 and TRAF6 are then recruited to the TLRs, which induces the association of IRAK-4 and MyD88 through their death domains. PMID: 17046325 Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.

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1282.0, 366.0
27.0, 27.0

p32

p32

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e63

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17046325 RAK-1 is phosphorylated by IRAK-4 and dissociates from the receptor together with TRAF6.

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1269.0, 437.0
30.0, 30.0

p33

p33

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e65

e66 e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 17046325 RAK-1 is phosphorylated by IRAK-4 and dissociates from the receptor together with TRAF6.

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1163.0, 439.0
25.0, 25.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 MO000016574 MO000016588 MO000022125 MO000022136 e13

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m68*m1573*m1583*m6433*m6443*m14*0.1

nodelay

--

true

0

false

PMID: 17046325 The released TRAF6 interacts with transforming growth factor (TGF)-beta-activated kinase (TAK)1, and TRAF6?TAK1 forms a large complex with E2 ubiquitin-conjugating enzyme (Ubc)13, ubiquitin-conjugating enzyme E2 variant 1 isoform A (Uev1A) and TAK1-binding protein (TAB)1?TAB2.

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1284.0, 512.0
24.0, 24.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17046325 The released TRAF6 interacts with transforming growth factor (TGF)-beta-activated kinase (TAK)1, and TRAF6?TAK1 forms a large complex with E2 ubiquitin-conjugating enzyme (Ubc)13, ubiquitin-conjugating enzyme E2 variant 1 isoform A (Uev1A) and TAK1-binding protein (TAB)1?TAB2. PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKC¦È co-operates with the CBM complex to culminate in NF-kappaB activation.

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1219.0, 587.0
25.0, 25.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e68 e5

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m73*m5*0.1

nodelay

--

true

0

false

PMID: 17046325 Activated TAK1 phosphorylates and activates the IKK complex, consisting of IKK1, IKK2 and NEMO. PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKC¦È co-operates with the CBM complex to culminate in NF-kappaB activation.

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1062.0, 638.0
27.0, 27.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e69 e103

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m74*m107*0.1

nodelay

--

true

0

false

PMID: 17046325 The IKK complex induces IkappaB phosphorylation, which results in I¦ÊB ubiquitination and degradation. PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKC¦È co-operates with the CBM complex to culminate in NF-kappaB activation.

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1223.0, 679.0
25.0, 25.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e68

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c136 : 1
stoichiometry:c132 : 1

m69*m73*0.1

nodelay

--

true

0

false

PMID: 17046325 Activated TAK1 also induces the activation of various stress kinases, including c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK).

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1186.0, 678.0
27.0, 27.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e68

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m21*m73*0.1

nodelay

--

true

0

false

PMID: 17046325 Activated TAK1 also induces the activation of various stress kinases, including c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK).

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281.0, 209.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000019422 e105

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c16 : 1
stoichiometry:c9 : 1

m3964*m3987*m109*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

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1062.0, 758.0
27.0, 27.0

p40

p40

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 17046325 The IKK complex induces IkappaB phosphorylation, which results in I¦ÊB ubiquitination and degradation. PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKC¦È co-operates with the CBM complex to culminate in NF-kappaB activation.

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1224.0, 760.0
23.0, 23.0

p41

p41

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e107

e74 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m111*0.1

nodelay

--

true

0

false

PMID: 17046325 The IKK complex induces IkappaB phosphorylation, which results in I¦ÊB ubiquitination and degradation. PMID: 17046325 IkappaB degradation liberates NF-kappaB and enables it to translocate into the nucleus where it can induce target gene expression. PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKC¦È co-operates with the CBM complex to culminate in NF-kappaB activation.

Go back
1063.0, 1239.0
25.0, 25.0

p42

p42

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000058

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17046325 IkappaB degradation liberates NF-kappaB and enables it to translocate into the nucleus where it can induce target gene expression.

Go back
1429.0, 393.0
30.0, 30.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e63

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17046325 Recently, it was revealed that IRF-5 interacts with, and is activated by, MyD88 and TRAF6, although it is unclear how IRAK-1, IRAK-4 and IRF-5 regulate TRAF6 dissociation from the receptor complex.

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1483.0, 831.0
25.0, 25.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e78 e81

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m82*m85*0.1

nodelay

--

true

0

false

PMID: 17046325 In acquired immunity, the TCR recognizes a specific antigen?MHC complex on APCs. PMID: 17046325 TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76.

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1487.0, 875.0
25.0, 25.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e80 MO000000138

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c151 : 1
stoichiometry:c150 : 1

m84*m123*0.1

nodelay

--

true

0

false

PMID: 17046325 TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76.

Go back
1488.0, 944.0
23.0, 23.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017772 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m2529*m86*0.1

nodelay

--

true

0

false

PMID: 17046325 TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76.

Go back
1282.0, 1002.0
27.0, 27.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e83 e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m87*m88*0.1

nodelay

--

true

0

false

PMID: 17046325 TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76. PMID: 17046325 PLC-gamma1 is recruited to the phosphorylated LAT?SLP-76 and generates Ins(1,4,5)P3.

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1291.0, 1051.0
26.0, 26.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e85 MO000017617

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c160 : 1

m89*m2395*0.1

nodelay

--

true

0

false

PMID: 17046325 PLC-gamma1 is recruited to the phosphorylated LAT?SLP-76 and generates Ins(1,4,5)P3.

Go back
1290.0, 1170.0
27.0, 27.0

p49

p49

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e86

MO000000332

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17046325 PLC-gamma1 is recruited to the phosphorylated LAT?SLP-76 and generates Ins(1,4,5)P3.

Go back
895.0, 1583.0
25.0, 25.0

p60

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e26 e96

MO000017214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c17 : 1
stoichiometry:c204 : 1

m30*m100*0.1

nodelay

--

true

0

false

PMID: 17046325, 16761317 Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.

Go back
1284.0, 1244.0
23.0, 23.0

p50

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017433 e88 MO000017142 MO000017617

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c168 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c164 : 1

m2259*m92*m2019*m2395*0.1

nodelay

--

true

0

false

PMID: 17046325 IRAK-4 affects only the phosphorylation of PKCtheta but not of CD3zeta, ZAP-70 or LAT. PMID: 17046325, 15802604 Although 3-phosphoinositide-dependent protein kinase (PDK)1 is responsible for activating PKCtheta and subsequent NF-kappaB activation after TCR stimulation , the association of IRAK-4 with PKCtheta or PDK1 was not observed. PMID: 17046325 It can be assumed that PKCbeta activation in B cells requires only PLC-gamma2 activation, whereas PKCtheta activation in T cells requires both PLC-gamma1 and IRAK-4.

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1482.0, 1190.0
27.0, 27.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e83 MO000039077

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m87*m17258*0.1

nodelay

--

true

0

false

PMID: 17046325 IRAK-4 constitutively associates with ZAP-70, and the assembled ZAP-70?IRAK-4 complex can be recruited to the TCR vicinity following stimulation.

Go back
1134.0, 1410.0
27.0, 27.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016724 e86

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c171 : 1
stoichiometry:c170 : 1

m1676*m90*0.1

nodelay

--

true

0

false

PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCtheta co-operates with the CBM complex to culminate in NF-kappaB activation.

Go back
1283.0, 1491.0
25.0, 25.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017212 e89 e100 e101 e102

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1
stoichiometry:c234 : 1
stoichiometry:c173 : 1

m2078*m93*m104*0.1

nodelay

--

true

0

false

PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCtheta co-operates with the CBM complex to culminate in NF-kappaB activation. PMID: 17046325 TCR signals could then have diversified into Ca2+-independent NF-kappaB activation and Ca2+-dependent NF-AT activation. PMID: 17046325 Cyclosporine A and FK506 specifically inhibit NF-AT activation in TCR signaling, and have been used for successful organ transplantation.

Go back
1139.0, 863.0
25.0, 25.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e87 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m91*m95*0.1

nodelay

--

true

0

false

PMID: 17046325 LAT?SLP-76?PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKC¦È co-operates with the CBM complex to culminate in NF-kappaB activation.

Go back
1487.0, 1331.0
25.0, 25.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017777 MO000000103

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m2534*m117377*0.1

nodelay

--

true

0

false

PMID:17046325, 16574867, 11861617 Functional analyses demonstrated that IRAK-4-deficient T cells failed to respond to TCR stimulation but were able to respond to phorbol 12-myristate 13-acetate (PMA) stimulation [25] that directly activates protein kinase C (PKC)theta.

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1295.0, 1331.0
25.0, 25.0

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e93 MO000017433

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m97*m2259*0.1

nodelay

--

true

0

false

PMID:17046325, 16574867, 11861617 Functional analyses demonstrated that IRAK-4-deficient T cells failed to respond to TCR stimulation but were able to respond to phorbol 12-myristate 13-acetate (PMA) stimulation [25] that directly activates protein kinase C (PKC)theta.

Go back
1186.0, 1634.0
27.0, 27.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000133

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m120*0.1

nodelay

--

true

0

false

PMID: 17046325 It can be assumed that PKCbeta activation in B cells requires only PLC-gamma2 activation, whereas PKCtheta activation in T cells requires both PLC-gamma1 and IRAK-4.

Go back
1231.0, 1635.0
25.0, 25.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017704 e94

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c206 : 1
stoichiometry:c191 : 1

m2464*m98*0.1

nodelay

--

true

0

false

PMID: 17046325 It can be assumed that PKCbeta activation in B cells requires only PLC-gamma2 activation, whereas PKCtheta activation in T cells requires both PLC-gamma1 and IRAK-4.

Go back
723.0, 1611.0
25.0, 25.0

p60

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e26 e97

MO000017151

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c15 : 1
stoichiometry:c18 : 1

m30*m101*0.1

nodelay

--

true

0

false

PMID: 17046325, 16761317 Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.

Go back
859.0, 1543.0
25.0, 25.0

p60

p60

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e96 e25

MO000017214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c203 : 1
stoichiometry:c193 : 1

m100*m29*0.1

nodelay

--

true

0

false

PMID: 17046325, 16761317 Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.

Go back
791.0, 1551.0
25.0, 25.0

p61

p61

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e97 e25

MO000017151

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c202 : 1
stoichiometry:c192 : 1

m101*m29*0.1

nodelay

--

true

0

false

PMID: 17046325, 16761317 Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.

Go back
584.0, 1464.0
23.0, 23.0

p62

p62

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e32

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c200 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
655.0, 1511.0
25.0, 25.0

p63

p63

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e33

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c221 : 1
stoichiometry:c201 : 1

m94230*m37*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
509.0, 1369.0
22.0, 22.0

p64

p64

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e37

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c222 : 1
stoichiometry:c199 : 1

m93423*m41*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
500.0, 1328.0
23.0, 23.0

p65

p65

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e33

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c219 : 1
stoichiometry:c217 : 1

m93423*m37*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
520.0, 1408.0
23.0, 23.0

p66

p66

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e38

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c223 : 1
stoichiometry:c218 : 1

m93423*m42*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
559.0, 1435.0
25.0, 25.0

p67

p67

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e32 e33

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c220 : 1
stoichiometry:c215 : 1

m36*m37*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
612.0, 1488.0
23.0, 23.0

p68

p68

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e32

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c216 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
688.0, 1528.0
23.0, 23.0

p69

p69

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e37

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c225 : 1
stoichiometry:c213 : 1

m94230*m41*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
424.0, 336.0
27.0, 27.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c24 : 1

m6810*m26*0.1

nodelay

--

true

0

false

PMID: 17046325 After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.

Go back
725.0, 1545.0
21.0, 21.0

p70

p70

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e38

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c224 : 1
stoichiometry:c214 : 1

m94230*m42*0.1

nodelay

--

true

0

false

PMID: 17046325, 16034093 In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.

Go back
955.0, 1547.0
25.0, 25.0

p71

p71

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e98 e63

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c230 : 1
stoichiometry:c226 : 1

m102*m67*0.1

nodelay

--

true

0

false

PMID: 17046325 Collectively, these studies demonstrated that some components from invading microorganisms stimulate TLRs on T cells directly, and enhance proliferation, cytokine and chemokine productions, and effector function.

Go back
1000.0, 1548.0
23.0, 23.0

p72

p72

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e99 e63

MO000000265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c231 : 1
stoichiometry:c227 : 1

m103*m67*0.1

nodelay

--

true

0

false

PMID: 17046325 Collectively, these studies demonstrated that some components from invading microorganisms stimulate TLRs on T cells directly, and enhance proliferation, cytokine and chemokine productions, and effector function.

Go back
496.0, 1288.0
23.0, 23.0

p73

p73

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e40

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c240 : 1
stoichiometry:c236 : 1

m93423*m44*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
496.0, 1256.0
23.0, 23.0

p74

p74

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e49

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c239 : 1
stoichiometry:c235 : 1

m93423*m66*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
505.0, 1221.0
21.0, 21.0

p75

p75

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e39 G010453

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c243 : 1

m43*m93423*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
840.0, 988.0
23.0, 23.0

p76

p76

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e79 e39

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c266 : 1
stoichiometry:c244 : 1

m83*m43*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
869.0, 989.0
21.0, 21.0

p77

p77

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e79 e37

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c268 : 1
stoichiometry:c245 : 1

m83*m41*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
893.0, 993.0
22.0, 22.0

p78

p78

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e79 e38

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c270 : 1
stoichiometry:c246 : 1

m83*m42*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
918.0, 998.0
19.0, 19.0

p79

p79

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e79 e49

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c272 : 1
stoichiometry:c247 : 1

m83*m66*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
497.0, 277.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e21

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m6810*m25*0.1

nodelay

--

true

0

false

PMID: 17046325 After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.

Go back
941.0, 1009.0
21.0, 21.0

p80

p80

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e79 e40

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c264 : 1
stoichiometry:c248 : 1

m83*m44*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
965.0, 1033.0
21.0, 21.0

p81

p81

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e39

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c267 : 1
stoichiometry:c259 : 1

m93217*m43*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
990.0, 1050.0
19.0, 19.0

p82

p82

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e37

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c269 : 1
stoichiometry:c260 : 1

m93217*m41*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
1013.0, 1065.0
21.0, 21.0

p83

p83

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e38

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c271 : 1
stoichiometry:c261 : 1

m93217*m42*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
1036.0, 1084.0
23.0, 23.0

p84

p84

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e49

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c273 : 1
stoichiometry:c262 : 1

m93217*m66*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
1061.0, 1093.0
21.0, 21.0

p85

p85

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e40

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c265 : 1
stoichiometry:c263 : 1

m93217*m44*0.1

nodelay

--

true

0

false

PMID: 17046325, 15229469 Only five TLRs ? TLR3, TLR4, TLR7, TLR8 and TLR9 ? produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.

Go back
498.5, 1174.5
19.0, 19.0

p86

p86

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e26

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c279 : 1
stoichiometry:c304 : 1
stoichiometry:c274 : 1

m93309*m30*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
510.5, 1142.5
19.0, 19.0

p87

p87

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e25

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c307 : 1
stoichiometry:c275 : 1

m93309*m29*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
586.5, 1070.5
19.0, 19.0

p88

p88

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e40

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c315 : 1
stoichiometry:c277 : 1

m93309*m44*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
526.5, 1114.5
19.0, 19.0

p89

p89

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e49

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c310 : 1
stoichiometry:c276 : 1

m93309*m66*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
585.0, 301.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c30 : 1
stoichiometry:c26 : 1

m1572*m28*0.1

nodelay

--

true

0

false

PMID: 17046325 After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.

Go back
554.5, 1090.5
19.0, 19.0

p90

p90

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e39

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c318 : 1
stoichiometry:c278 : 1

m93309*m43*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
596.5, 1048.5
17.0, 17.0

p91

p91

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e26

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c294 : 1
stoichiometry:c305 : 1
stoichiometry:c284 : 1

m93248*m30*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
612.5, 1028.5
17.0, 17.0

p92

p92

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e25

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c308 : 1
stoichiometry:c285 : 1

m93248*m29*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
628.5, 1004.5
19.0, 19.0

p93

p93

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e49

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c296 : 1
stoichiometry:c311 : 1
stoichiometry:c286 : 1

m93248*m66*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
656.5, 996.5
19.0, 19.0

p94

p94

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e39

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c316 : 1
stoichiometry:c287 : 1

m93248*m43*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
684.5, 1000.5
19.0, 19.0

p95

p95

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e40

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c314 : 1
stoichiometry:c288 : 1

m93248*m44*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
712.5, 1004.5
19.0, 19.0

p96

p96

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17 e26

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c299 : 1
stoichiometry:c306 : 1
stoichiometry:c289 : 1

m19*m30*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
736.5, 988.5
19.0, 19.0

p97

p97

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17 e25

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c300 : 1
stoichiometry:c309 : 1
stoichiometry:c290 : 1

m19*m29*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
760.5, 980.5
19.0, 19.0

p98

p98

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17 e49

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c312 : 1
stoichiometry:c291 : 1

m19*m66*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
784.5, 980.5
21.0, 21.0

p99

p99

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17 e39

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c302 : 1
stoichiometry:c317 : 1
stoichiometry:c292 : 1

m19*m43*0.1

nodelay

--

true

0

false

PMID: 17046325 In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).

Go back
1388.0, 99.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.99276672546495, 219.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.223472969005, 261.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.0, 312.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.5907742895922, 236.84024471299028

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.0, 288.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 224.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.1402359056143, 206.12810910798558

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.0, 412.6354015681656

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.0, 415.66572975631465

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 421.44996637779775

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 418.6568623949399

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.1248421192625, 231.63821725238935

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1013.0, 315.06689391919036

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1314.9586826857844, 325.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1309.0, 380.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1305.3024573305795, 397.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1299.0, 452.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1246.0, 452.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1196.0, 452.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1115.0, 422.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1112.0, 452.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 460.1021823152076

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.387607397048, 441.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1081.0, 468.19409903942767

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.0, 470.7839864320407

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.0, 464.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.0, 524.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1296.0, 536.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1251.923938185422, 594.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1187.0, 600.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1190.4219507836356, 610.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.0, 652.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.0, 665.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.082309905461, 440.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1096.9959718023629, 649.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1254.0326527670904, 654.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1248.0, 692.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1166.0, 692.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1175.8362976331207, 704.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1218.5316554342842, 609.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1248.1629613814036, 615.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1076.0, 727.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 772.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.0, 772.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.0, 108.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1247.0, 772.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1152.8393213929166, 783.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1082.2026994626583, 1033.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.5023278166561, 1264.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1394.0, 334.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1395.5099485156277, 423.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1400.0, 850.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1496.0, 806.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1408.0, 844.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1387.0, 788.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.5244112231268, 1503.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1399.5570469020754, 893.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1389.0, 884.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1319.0, 956.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1392.0, 935.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1403.1863898227368, 962.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1258.0, 1016.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1263.897233121606, 1028.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1258.0, 1064.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1273.0, 1083.9352504244603

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1317.0, 1016.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
242.0, 221.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1304.0, 1077.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1304.0, 1141.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1274.0, 1184.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1251.0, 1256.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1257.099660075834, 1267.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1394.0, 1044.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.0, 521.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1403.3487331605156, 1210.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1315.0, 1256.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1169.0, 1424.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 1467.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1161.0, 1430.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1147.8391630919061, 1135.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1233.0, 1518.9975603804353

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1296.0, 1516.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1243.0, 1470.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1155.5483880546972, 895.8487256565681

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1108.0, 885.2926937794119

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.9425724154553, 855.2905467105794

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.0, 782.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1215.0, 778.3861999450876

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 1625.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1396.0, 1354.5461526917568

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1500.0, 1364.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1399.0, 1344.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1328.0, 1344.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1248.0, 1271.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1271.0, 1344.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1221.0, 1267.051374836607

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1268.0, 1146.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1162.0, 1648.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1212.0, 1616.145770236779

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.020613557655, 306.2680368629481

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1262.2469504755443, 1615.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.0, 1648.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.0, 1576.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 1568.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.0, 1503.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 1467.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.9134030547406, 1424.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
685.6568542494924, 1446.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.6869522758353, 1329.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
462.1554175279993, 1350.5777087639997

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1343.0, 156.65685424949237

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.9987017202122, 348.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.0, 1476.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.7462185896749, 1528.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
134.28703068801204, 62.00017142367486

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
110.28212631820224, 46.011902653595655

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
889.7455923043988, 1608.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1020.3890177997333, 259.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1244.0, 1610.0

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.8446454055273, 1323.0

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.9872450910601, 1334.0

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.7700191719663, 1420.0

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.0, 344.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.3461425405233, 1429.0

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
710.8487818202127, 1446.0

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
739.507835599539, 1446.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0, 1540.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.9345441785347, 1543.0212779635738

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.2436714876709, 1454.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.8264389163953, 1480.6573635352368

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
463.0, 1340.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.0148776388582, 1358.2745850063834

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.0, 1159.0

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
507.0, 237.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.0, 1159.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
384.0, 1157.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
83.5118339886543, 509.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
533.5706412041878, 555.0

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
599.0, 555.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
64.01795662750396, 504.2500806117424

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.0, 1560.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1023.0, 1560.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.0, 1453.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1012.0, 1410.0

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.0, 231.98691099462607

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.0070713966412, 309.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1012.0320677123219, 288.09489551382876

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1296.0, 1470.0

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1190.0, 1487.0

c233

c233

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1183.0, 1505.3585507979835

c234

c234

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
458.5325719930081, 1279.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.9041157547755, 1307.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.1734860663945, 1277.5413412226505

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.8595779966347, 1303.49232493607

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
35.61019377809248, 35.54681602335825

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.09267876932364, 357.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
7.586557617339167, 15.543667873073673

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.7108348131865, 851.0

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.897233121606, 1246.4057970281387

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.59815395945674, 1242.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 910.765824498571

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.0, 911.487007374633

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.0, 911.9282586084793

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.5096012338028, 911.9837526629091

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.922878507708, 911.7654708965133

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.635762733503, 1018.1260949576658

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.9605096827424, 315.7939052783328

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.6518879601005, 1017.5476811172091

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
907.6948971412676, 1022.8183964903632

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
929.565954317127, 1024.97995587149

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
941.0, 1037.975697130794

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.1691052210591, 1061.7003235347597

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1002.244505134755, 1076.9026076056937

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1024.0, 1094.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1027.0, 1114.8237034496276

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1031.0, 1121.2920404516058

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
986.0, 1034.9287423733235

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 232.8676255087126

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.0, 1039.7785148465887

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1034.0, 1048.2235169765556

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 1052.3335677176674

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1073.0, 1052.9930645847387

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.5843530487314, 227.0

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1089.9986219647533, 27.503002727994698

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 839.0

c266

c266

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 837.0

c267

c267

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.0, 533.0

c268

c268

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
554.0, 529.0

c269

c269

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.9701495707417, 355.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.0, 555.0

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 553.0

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 211.0

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.0, 211.0

c273

c273

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.0309682041927, 1049.9102312071875

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
434.1093553863216, 1049.1558498630382

c275

c275

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.2723665956941, 1044.9656235549244

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.6865887294472, 1034.2172852104175

c277

c277

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.20127401132413, 1038.4844874248342

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.9416647319606, 1185.9643450031667

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.0, 393.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.5654927944389, 1157.6006381480884

c280

c280

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.8923076923077, 1134.0615384615385

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.7587543633655, 1114.5530845646738

c282

c282

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.1660736161774, 1096.8296288789795

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.4260611433292, 981.9886464374226

c284

c284

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.1049392463369, 981.7181105699019

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.4867851613561, 980.6233495239067

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.6325770306054, 974.4731333462222

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.053316066963, 970.7750142330225

c288

c288

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 932.4875986097949

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.8415826524321, 410.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 932.9459451369956

c290

c290

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
773.0, 933.6031770323575

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.0, 933.9986780137066

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.6374626626937, 933.5527339886228

c293

c293

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.9619305082008, 1070.3343588757587

c294

c294

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.0560627139106, 1052.199695946819

c295

c295

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
646.9929776408934, 1030.9322528487733

c296

c296

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.7656428706189, 1023.5067449345369

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
697.5220682521361, 1027.8538721810226

c298

c298

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
733.8461661729306, 1030.3651137793713

c299

c299

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1388.0, 151.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 225.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.4097271056062, 1015.2369718159804

c300

c300

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
775.1340489975697, 1007.7101125073485

c301

c301

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.7242859683402, 1009.9671456517416

c302

c302

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.0, 1015.918066071375

c303

c303

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
380.0, 463.0

c304

c304

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
384.0, 463.0

c305

c305

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 463.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.8320639673764, 225.0

c307

c307

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 225.0

c308

c308

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.0, 225.0

c309

c309

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
285.0, 658.9990241521741

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.147308260902, 211.0

c310

c310

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.3322069034581, 211.0

c311

c311

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.0, 211.0

c312

c312

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
831.7592484869251, 227.0

c313

c313

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
702.7233319079704, 227.0

c314

c314

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.089579107751, 227.0

c315

c315

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 851.0

c316

c316

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 842.0

c317

c317

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
566.1867236234419, 851.0

c318

c318

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1318.0, 1120.0

c319

c319

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
350.739672181449, 659.0242219551482

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1318.0, 1456.0

c320

c320

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 152.0

c321

c321

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1132.0, 806.4151336375552

c322

c322

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1151.1326884363073, 811.0

c323

c323

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.0, 642.277510751307

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.0, 678.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.8152001391701, 698.7095750304435

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 704.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.3281261544708, 816.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.0, 886.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.0, 879.6214926735981

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.0, 298.549839799778

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.90697358120497, 1023.2164574740315

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 1040.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 1027.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.76092576117605, 357.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.0, 1091.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 1136.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.04504651041975, 358.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.9999959945804, 371.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 578.7734525962109

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.55988858752204, 566.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1145.0, 255.17772435070177

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
429.0, 738.9207002305476

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.67527876136614, 568.5394219638499

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 799.3531602401445

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.1172937396932, 368.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 792.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.3327225677855, 478.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.145770236779, 478.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.9277740355816, 481.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.1804346114993, 513.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.8074888811523, 515.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1152.5590999075698, 205.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.3192789417286, 521.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.4906334205524, 558.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.8986429702136, 554.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.8446022264794, 567.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.9209918144369, 577.1215563631062

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.912568998762, 596.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.4739244227113, 610.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.3668216987254, 582.1192848634242

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.9842246257599, 623.5021524921862

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.1086450884858, 649.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.0, 165.99811031059133

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.4066790230174, 586.7910817041695

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.6613154372152, 627.3030948246843

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.8559863845442, 686.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.0, 594.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.0, 542.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.0, 806.3887333080002

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.5418636464293, 539.5857022873224

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 561.5818427047461

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 795.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 75.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
379.69082189313593, 165.09773440987675

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 126.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.0, 118.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1123.0, 124.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1116.0, 132.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1037.4219507836356, 148.77059201070074

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 155.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.3104235544095, 147.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
950.6134655807892, 152.5357429061181

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 130.20817024215768

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.0, 146.27236659569408

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 234.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.0, 145.4605108969397

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1240.0, 140.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.0, 153.91641974156164

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 146.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.0, 158.80352801654166

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.885143449429, 157.9932582089723

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 151.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.2880650933222, 168.75370252198243

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 91.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 162.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back