_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e12
_enti_e53
_enti_e59
_enti_e11
_enti_e6
_enti_e54
_enti_e56
_enti_e50
_enti_e52
_enti_e51
_enti_e58
_enti_e57
_enti_e61
_enti_e62
_enti_e60
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g1
g1_fact_g14
g1_fact_g3
p1_propro_p1
PMID: 17046325
Following ligand stimulation, TLRs associate with adaptor proteins such as myeloid differentiation primary response gene (MyD)88 through interaction between the individual Toll and interleukin-1 receptor (TIR) domains.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17046325
Following ligand stimulation, TLRs associate with adaptor proteins such as myeloid differentiation primary response gene (MyD)88 through interaction between the individual Toll and interleukin-1 receptor (TIR) domains.
c4 cso30:c:InputProcess connector
c6 cso30:c:InputProcess connector
c5 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c321 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c16 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 17046325
After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.
c20 cso30:c:InputProcess connector
c21 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17046325
After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.
c19 cso30:c:InputProcess connector
c22 cso30:c:InputProcess connector
c23 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17046325
After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.
c25 cso30:c:InputProcess connector
c30 cso30:c:InputProcess connector
c26 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17046325
After TLR1, TLR2 and/or TLR6 stimulation, TIR domain-containing adaptor protein (TIRAP) and MyD88 are recruited to TLRs.
c27 cso30:c:InputProcess connector
c28 cso30:c:InputProcess connector
c29 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c31 cso30:c:InputProcess connector
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c37 cso30:c:InputProcess connector
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c40 cso30:c:InputProcess connector
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17046325
Following TLR5 stimulation, MyD88 but not TIRAP is recruited into the receptor complex.
c43 cso30:c:InputProcess connector
c44 cso30:c:InputProcess connector
c45 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17046325
Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.
c46 cso30:c:InputProcess connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17046325
Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.
c47 cso30:c:InputProcess connector
c50 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17046325
Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.
c52 cso30:c:InputProcess connector
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17046325
Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.
c56 cso30:c:InputProcess connector
c59 cso30:c:InputProcess connector
c61 cso30:c:InputProcess connector
c65 cso30:c:InputProcess connector
c68 cso30:c:InputProcess connector
c71 cso30:c:InputProcess connector
c73 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17046325
Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.
c55 cso30:c:InputProcess connector
c58 cso30:c:InputProcess connector
c62 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c67 cso30:c:InputProcess connector
c70 cso30:c:InputProcess connector
c74 cso30:c:InputProcess connector
c76 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 17046325
Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.
c57 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c63 cso30:c:InputProcess connector
c66 cso30:c:InputProcess connector
c69 cso30:c:InputProcess connector
c72 cso30:c:InputProcess connector
c75 cso30:c:InputProcess connector
c78 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c79 cso30:c:InputProcess connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17046325
However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon β (TRIF)-related adaptor molecule (TRAM)TRIFRIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAPMyD88 signaling pathway.
c84 cso30:c:InputProcess connector
c85 cso30:c:InputProcess connector
c86 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 17046325
However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon β (TRIF)-related adaptor molecule (TRAM)TRIFRIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAPMyD88 signaling pathway.
c83 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 17046325
However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon β (TRIF)-related adaptor molecule (TRAM)TRIFRIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAPMyD88 signaling pathway.
c89 cso30:c:InputProcess connector
c90 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17046325
However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon β (TRIF)-related adaptor molecule (TRAM)TRIFRIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAPMyD88 signaling pathway.
c87 cso30:c:InputProcess connector
c92 cso30:c:InputProcess connector
c93 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 17046325
However, after TLR4 stimulation, the TIR domain-containing adaptor protein inducing interferon β (TRIF)-related adaptor molecule (TRAM)TRIFRIP1 (receptor-interacting protein 1) signaling pathway is activated in addition to the TIRAPMyD88 signaling pathway.
c94 cso30:c:InputProcess connector
c95 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c97 cso30:c:InputProcess connector
c98 cso30:c:InputProcess connector
c99 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 17046325
TLR3 signaling, only TRIF and RIP1 are recruited. The TRAMTRIFRIP1 signaling pathway is MyD88-independent but IRAK-4-dependent.
c100 cso30:c:InputProcess connector
c101 cso30:c:InputProcess connector
c102 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 17046325
TLR3 signaling, only TRIF and RIP1 are recruited. The TRAMTRIFRIP1 signaling pathway is MyD88-independent but IRAK-4-dependent.
c103 cso30:c:InputProcess connector
c104 cso30:c:InputProcess connector
c105 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 17046325
IRAK-4, IRAK-1, IRF5 and TRAF6 are then recruited to the TLRs, which induces the association of IRAK-4 and MyD88 through their death domains.
PMID: 17046325
Following TLR7, TLR8 and/or TLR9 stimulation, a cytoplasmic signaling complex consisting of MyD88, IRAK-1, interferon regulatory factor (IRF)-5, IRF-7, TNF receptor-associated factor (TRAF)3, TRAF6 and IRAK-4 is formed.
c106 cso30:c:InputProcess connector
c107 cso30:c:InputProcess connector
c108 cso30:c:InputProcess connector
c109 cso30:c:InputProcess connector
c205 cso30:c:InputProcess connector
c110 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 17046325
RAK-1 is phosphorylated by IRAK-4 and dissociates from the receptor together with TRAF6.
c111 cso30:c:InputProcess connector
c112 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 17046325
RAK-1 is phosphorylated by IRAK-4 and dissociates from the receptor together with TRAF6.
c113 cso30:c:InputProcess connector
c114 cso30:c:OutputProcess connector
c115 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 17046325
The released TRAF6 interacts with transforming growth factor (TGF)-beta-activated kinase (TAK)1, and TRAF6TAK1 forms a large complex with E2 ubiquitin-conjugating enzyme (Ubc)13, ubiquitin-conjugating enzyme E2 variant 1 isoform A (Uev1A) and TAK1-binding protein (TAB)1TAB2.
c116 cso30:c:InputProcess connector
c117 cso30:c:InputProcess connector
c118 cso30:c:InputProcess connector
c119 cso30:c:InputProcess connector
c120 cso30:c:InputProcess connector
c121 cso30:c:InputProcess connector
c122 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 17046325
The IKK complex induces IkappaB phosphorylation, which results in IκB ubiquitination and degradation.
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCθ co-operates with the CBM complex to culminate in NF-kappaB activation.
c130 cso30:c:InputAssociation connector
c128 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 17046325
Activated TAK1 also induces the activation of various stress kinases, including c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK).
c131 cso30:c:InputProcess connector
c136 cso30:c:InputAssociation connector
c132 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 17046325
Activated TAK1 also induces the activation of various stress kinases, including c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK).
c133 cso30:c:InputProcess connector
c135 cso30:c:InputAssociation connector
c134 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 17046325
The IKK complex induces IkappaB phosphorylation, which results in IκB ubiquitination and degradation.
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCθ co-operates with the CBM complex to culminate in NF-kappaB activation.
c137 cso30:c:InputProcess connector
c138 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 17046325
The IKK complex induces IkappaB phosphorylation, which results in IκB ubiquitination and degradation.
PMID: 17046325
IkappaB degradation liberates NF-kappaB and enables it to translocate into the nucleus where it can induce target gene expression.
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCθ co-operates with the CBM complex to culminate in NF-kappaB activation.
c139 cso30:c:InputProcess connector
c140 cso30:c:OutputProcess connector
c141 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 17046325
The released TRAF6 interacts with transforming growth factor (TGF)-beta-activated kinase (TAK)1, and TRAF6TAK1 forms a large complex with E2 ubiquitin-conjugating enzyme (Ubc)13, ubiquitin-conjugating enzyme E2 variant 1 isoform A (Uev1A) and TAK1-binding protein (TAB)1TAB2.
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCθ co-operates with the CBM complex to culminate in NF-kappaB activation.
c123 cso30:c:InputProcess connector
c124 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 17046325
Activated TAK1 phosphorylates and activates the IKK complex, consisting of IKK1, IKK2 and NEMO.
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCθ co-operates with the CBM complex to culminate in NF-kappaB activation.
c125 cso30:c:InputAssociation connector
c126 cso30:c:InputProcess connector
c127 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 17046325
IkappaB degradation liberates NF-kappaB and enables it to translocate into the nucleus where it can induce target gene expression.
c142 cso30:c:InputProcess connector
c143 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 17046325
Recently, it was revealed that IRF-5 interacts with, and is activated by, MyD88 and TRAF6, although it is unclear how IRAK-1, IRAK-4 and IRF-5 regulate TRAF6 dissociation from the receptor complex.
c144 cso30:c:InputProcess connector
c145 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 17046325
In acquired immunity, the TCR recognizes a specific antigenMHC complex on APCs.
PMID: 17046325
TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76.
c147 cso30:c:InputProcess connector
c149 cso30:c:InputProcess connector
c148 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 17046325
TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76.
c146 cso30:c:InputProcess connector
c151 cso30:c:InputAssociation connector
c150 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 17046325
TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76.
c152 cso30:c:InputProcess connector
c153 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 17046325
TCR engagement results in the phosphorylation of TCR-associated CD3zeta chains by Lck and the recruitment of ZAP-70 to the phosphorylated CD3zeta chains, inducing phosphorylation of the adaptor proteins LAT and SLP-76.
PMID: 17046325
PLC-gamma1 is recruited to the phosphorylated LATSLP-76 and generates Ins(1,4,5)P3.
c159 cso30:c:InputAssociation connector
c155 cso30:c:InputProcess connector
c156 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 17046325
PLC-gamma1 is recruited to the phosphorylated LATSLP-76 and generates Ins(1,4,5)P3.
c157 cso30:c:InputProcess connector
c158 cso30:c:InputProcess connector
c160 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 17046325
PLC-gamma1 is recruited to the phosphorylated LATSLP-76 and generates Ins(1,4,5)P3.
c161 cso30:c:InputAssociation connector
c162 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 17046325
IRAK-4 constitutively associates with ZAP-70, and the assembled ZAP-70IRAK-4 complex can be recruited to the TCR vicinity following stimulation.
c165 cso30:c:InputProcess connector
c166 cso30:c:InputProcess connector
c167 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 17046325
IRAK-4 affects only the phosphorylation of PKCtheta but not of CD3zeta, ZAP-70 or LAT.
PMID: 17046325, 15802604
Although 3-phosphoinositide-dependent protein kinase (PDK)1 is responsible for activating PKCtheta and subsequent NF-kappaB activation after TCR stimulation , the association of IRAK-4 with PKCtheta or PDK1 was not observed.
PMID: 17046325
It can be assumed that PKCbeta activation in B cells requires only PLC-gamma2 activation, whereas PKCtheta activation in T cells requires both PLC-gamma1 and IRAK-4.
c163 cso30:c:InputProcess connector
c168 cso30:c:InputAssociation connector
c186 cso30:c:InputAssociation connector
c187 cso30:c:InputAssociation connector
c164 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCtheta co-operates with the CBM complex to culminate in NF-kappaB activation.
c169 cso30:c:InputProcess connector
c171 cso30:c:InputAssociation connector
c170 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCtheta co-operates with the CBM complex to culminate in NF-kappaB activation.
PMID: 17046325
TCR signals could then have diversified into Ca2+-independent NF-kappaB activation and Ca2+-dependent NF-AT activation.
PMID: 17046325
Cyclosporine A and FK506 specifically inhibit NF-AT activation in TCR signaling, and have been used for successful organ transplantation.
c172 cso30:c:InputProcess connector
c174 cso30:c:InputAssociation connector
c232 cso30:c:InputAssociation connector
c233 cso30:c:InputInhibitor connector
c234 cso30:c:InputInhibitor connector
c173 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCθ co-operates with the CBM complex to culminate in NF-kappaB activation.
c175 cso30:c:InputProcess connector
c176 cso30:c:InputProcess connector
c177 cso30:c:OutputProcess connector
p56_propro_p56
PMID:17046325, 16574867, 11861617
Functional analyses demonstrated that IRAK-4-deficient T cells failed to respond to TCR stimulation but were able to respond to phorbol 12-myristate 13-acetate (PMA) stimulation [25] that directly activates protein kinase C (PKC)theta.
c180 cso30:c:InputProcess connector
c181 cso30:c:InputProcess connector
c182 cso30:c:OutputProcess connector
p57_propro_p57
PMID:17046325, 16574867, 11861617
Functional analyses demonstrated that IRAK-4-deficient T cells failed to respond to TCR stimulation but were able to respond to phorbol 12-myristate 13-acetate (PMA) stimulation [25] that directly activates protein kinase C (PKC)theta.
c183 cso30:c:InputAssociation connector
c184 cso30:c:InputProcess connector
c185 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 17046325
It can be assumed that PKCbeta activation in B cells requires only PLC-gamma2 activation, whereas PKCtheta activation in T cells requires both PLC-gamma1 and IRAK-4.
c188 cso30:c:InputProcess connector
c189 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 17046325
It can be assumed that PKCbeta activation in B cells requires only PLC-gamma2 activation, whereas PKCtheta activation in T cells requires both PLC-gamma1 and IRAK-4.
c190 cso30:c:InputProcess connector
c206 cso30:c:InputAssociation connector
c191 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 17046325, 16761317
Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.
c195 cso30:c:InputAssociation connector
c203 cso30:c:InputAssociation connector
c193 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 17046325, 16761317
Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.
c194 cso30:c:InputAssociation connector
c202 cso30:c:InputAssociation connector
c192 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c196 cso30:c:InputAssociation connector
c200 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c197 cso30:c:InputAssociation connector
c221 cso30:c:InputAssociation connector
c201 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c198 cso30:c:InputAssociation connector
c222 cso30:c:InputAssociation connector
c199 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c207 cso30:c:InputAssociation connector
c219 cso30:c:InputAssociation connector
c217 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c208 cso30:c:InputAssociation connector
c223 cso30:c:InputAssociation connector
c218 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c209 cso30:c:InputAssociation connector
c220 cso30:c:InputAssociation connector
c215 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c210 cso30:c:InputAssociation connector
c216 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c211 cso30:c:InputAssociation connector
c225 cso30:c:InputAssociation connector
c213 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 17046325, 16034093
In the absence of antigen-presenting cells (APCs), flagellin (a TLR5 ligand) and R-848 (a TLR7 and/or TLR8 ligand) are synergized by suboptimal TCR-dependent or TCR-independent stimulation to enhance the proliferation and production of IFN-gamma, IL-8 and IL-10 by human CD4+ T cells.
c212 cso30:c:InputAssociation connector
c224 cso30:c:InputAssociation connector
c214 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 17046325
Collectively, these studies demonstrated that some components from invading microorganisms stimulate TLRs on T cells directly, and enhance proliferation, cytokine and chemokine productions, and effector function.
c228 cso30:c:InputAssociation connector
c230 cso30:c:InputAssociation connector
c226 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 17046325
Collectively, these studies demonstrated that some components from invading microorganisms stimulate TLRs on T cells directly, and enhance proliferation, cytokine and chemokine productions, and effector function.
c229 cso30:c:InputAssociation connector
c231 cso30:c:InputAssociation connector
c227 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c238 cso30:c:InputAssociation connector
c240 cso30:c:InputAssociation connector
c236 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c237 cso30:c:InputAssociation connector
c239 cso30:c:InputAssociation connector
c235 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c241 cso30:c:InputAssociation connector
c242 cso30:c:InputAssociation connector
c243 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c249 cso30:c:InputAssociation connector
c266 cso30:c:InputAssociation connector
c244 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c250 cso30:c:InputAssociation connector
c268 cso30:c:InputAssociation connector
c245 cso30:c:OutputProcess connector
p78_propro_p78
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c251 cso30:c:InputAssociation connector
c270 cso30:c:InputAssociation connector
c246 cso30:c:OutputProcess connector
p79_propro_p79
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c252 cso30:c:InputAssociation connector
c272 cso30:c:InputAssociation connector
c247 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c253 cso30:c:InputAssociation connector
c264 cso30:c:InputAssociation connector
c248 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c254 cso30:c:InputAssociation connector
c267 cso30:c:InputAssociation connector
c259 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c255 cso30:c:InputAssociation connector
c269 cso30:c:InputAssociation connector
c260 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c256 cso30:c:InputAssociation connector
c271 cso30:c:InputAssociation connector
c261 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c257 cso30:c:InputAssociation connector
c273 cso30:c:InputAssociation connector
c262 cso30:c:OutputProcess connector
p85_propro_p85
PMID: 17046325, 15229469
Only five TLRs TLR3, TLR4, TLR7, TLR8 and TLR9 produce IFNalpha, IFNbeta and IFNgamma as innate immune responses.
c258 cso30:c:InputAssociation connector
c265 cso30:c:InputAssociation connector
c263 cso30:c:OutputProcess connector
p86_propro_p86
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c279 cso30:c:InputAssociation connector
c304 cso30:c:InputAssociation connector
c274 cso30:c:OutputProcess connector
p87_propro_p87
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c280 cso30:c:InputAssociation connector
c307 cso30:c:InputAssociation connector
c275 cso30:c:OutputProcess connector
p88_propro_p88
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c283 cso30:c:InputAssociation connector
c315 cso30:c:InputAssociation connector
c277 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c281 cso30:c:InputAssociation connector
c310 cso30:c:InputAssociation connector
c276 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c282 cso30:c:InputAssociation connector
c318 cso30:c:InputAssociation connector
c278 cso30:c:OutputProcess connector
p91_propro_p91
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c294 cso30:c:InputAssociation connector
c305 cso30:c:InputAssociation connector
c284 cso30:c:OutputProcess connector
p92_propro_p92
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c295 cso30:c:InputAssociation connector
c308 cso30:c:InputAssociation connector
c285 cso30:c:OutputProcess connector
p93_propro_p93
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c296 cso30:c:InputAssociation connector
c311 cso30:c:InputAssociation connector
c286 cso30:c:OutputProcess connector
p94_propro_p94
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c297 cso30:c:InputAssociation connector
c316 cso30:c:InputAssociation connector
c287 cso30:c:OutputProcess connector
p95_propro_p95
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c298 cso30:c:InputAssociation connector
c314 cso30:c:InputAssociation connector
c288 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c299 cso30:c:InputAssociation connector
c306 cso30:c:InputAssociation connector
c289 cso30:c:OutputProcess connector
p97_propro_p97
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c300 cso30:c:InputAssociation connector
c309 cso30:c:InputAssociation connector
c290 cso30:c:OutputProcess connector
p98_propro_p98
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c301 cso30:c:InputAssociation connector
c312 cso30:c:InputAssociation connector
c291 cso30:c:OutputProcess connector
p99_propro_p99
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c302 cso30:c:InputAssociation connector
c317 cso30:c:InputAssociation connector
c292 cso30:c:OutputProcess connector
p100_propro_p100
PMID: 17046325
In vitro, these cells from IRAK-4-deficient mice failed to produce pro-inflammatory cytokines such as IL-1, IL-6 and tumor necrosis factor (TNF) in response to various ligands for TLR2, TLR3, TLR4 and TLR9 including lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (polyI:C), and oligodeoxynucleotides (ODNs) that contain unmethylated CpG motifs (CpG-ODNs).
c303 cso30:c:InputAssociation connector
c313 cso30:c:InputAssociation connector
c293 cso30:c:OutputProcess connector
p101_propro_p101
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCtheta co-operates with the CBM complex to culminate in NF-kappaB activation.
c319 cso30:c:InputAssociation connector
c320 cso30:c:OutputProcess connector
p60_propro_p5
PMID: 17046325, 16761317
Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.
c13 cso30:c:InputAssociation connector
c17 cso30:c:InputAssociation connector
c204 cso30:c:OutputProcess connector
p60_propro_p6
PMID: 17046325, 16761317
Indeed, TLR2 induces co-stimulation in activated CD8+ T cells for proliferation and survival through the enhanced expression of CD25 and Bcl-xL.
c12 cso30:c:InputAssociation connector
c15 cso30:c:InputAssociation connector
c18 cso30:c:OutputProcess connector
p41_propro_p102
PMID: 17046325
LATSLP-76PLCgamma1 induces Ca2+ mobilization, the activation of calcineurin and, finally, NF-AT activation (iv), whereas PKCθ co-operates with the CBM complex to culminate in NF-kappaB activation.
c322 cso30:c:InputAssociation connector
c178 cso30:c:InputProcess connector
c179 cso30:c:OutputProcess connector
c323 cso30:c:OutputProcess connector
TLR4_enti_MO000019394
TLR4
TLRs_enti_MO000019395
TLRs
TLR1_enti_MO000019396
TLR1
TLR2_enti_MO000019397
TLR2
TLR3_enti_MO000019398
TLR3
TLR5_enti_MO000019399
TLR5
TLR6_enti_MO000019422
TLR6
TLR8_enti_MO000042007
TLR8
TLR9_enti_MO000042012
TLR9
TLR7_enti_MO000042126
TLR7
MyD88_enti_MO000016573
MyD88
IRAK-1_enti_MO000000213
IRAK-1
IRAK-4_enti_MO000039077
IRAK-4
TRAF6_enti_MO000000212
TRAF6
TAK1_enti_MO000016574
TAK1
TAB1_enti_MO000016588
TAB1
TAB2_enti_MO000022125
TAB2
IKK-alpha:IKK-beta:IKK-gamma_enti_e5
IKK-alpha:IKK-beta:IKK-gamma
NF-kappaB {activated}_enti_MO000000058
NF-kappaB {activated}
IRF-5_enti_MO000007700
IRF-5
MAPKs_enti_MO000000077
MAPKs
JNK_enti_MO000000023
JNK
Ubc13_enti_MO000022136
Ubc13
Uev1A_enti_e13
Uev1A
TRAM_enti_MO000041132
TRAM
TRIF_enti_MO000041125
TRIF
RIP1_enti_MO000000065
RIP1
TLR ligand_enti_e14
TLR ligand
TLR ligand: TLR_enti_e15
TLR ligand: TLR
TLR ligand: TLR: MyD88_enti_e16
TLR ligand: TLR: MyD88
IL-1_enti_MO000000214
IL-1
IL1_enti_e17
IL1
TIRAP_enti_MO000022528
TIRAP
TLR2: TLR1: Triacyl lipopeptide_enti_e21
TLR2: TLR1: Triacyl lipopeptide
TLR2: TLR6: Diacyl lipopeptide_enti_e22
TLR2: TLR6: Diacyl lipopeptide
TLR2: TLR6: Diacyl lipopeptide: TIRAP_enti_e23
TLR2: TLR6: Diacyl lipopeptide: TIRAP
TLR2: TLR1: Triacyl lipopeptide: TIRAP_enti_e24
TLR2: TLR1: Triacyl lipopeptide: TIRAP
TLR2: TLR1: Triacyl lipopeptide: TIRAP: MyD88_enti_e25
TLR2: TLR1: Triacyl lipopeptide: TIRAP: MyD88
TLR2: TLR6:Diacyl lipopeptide: TIRAP: MyD88_enti_e26
TLR2: TLR6:Diacyl lipopeptide: TIRAP: MyD88
flagellin_enti_MO000022185
flagellin
IL-6_enti_G010262
IL-6
IL-6_enti_MO000007384
IL-6
LPS_enti_MO000016882
LPS
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
CpG DNA_enti_e18
CpG DNA
R-848_enti_e27
R-848
R-848: TLR7_enti_e28
R-848: TLR7
R-848: TLR8_enti_e29
R-848: TLR8
CpG DNA: TLR9_enti_e30
CpG DNA: TLR9
IFN-gamma_enti_G010453
IFN-gamma
IFNgamma_enti_MO000016665
IFNgamma
flagellin: TLR5_enti_e31
flagellin: TLR5
IL-8_enti_MO000017264
IL-8
IL8_enti_e32
IL8
flagellin: TLR5: MyD88_enti_e33
flagellin: TLR5: MyD88
IRF-7_enti_MO000007702
IRF-7
R-848: TLR7: MyD88_enti_e34
R-848: TLR7: MyD88
R-848: TLR8: MyD88_enti_e35
R-848: TLR8: MyD88
CpG DNA: TLR9: MyD88_enti_e36
CpG DNA: TLR9: MyD88
TRAF3_enti_MO000016963
TRAF3
R-848: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7_enti_e37
R-848: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7
R-848: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7_enti_e38
R-848: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7_enti_e39
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: TRAF3: IRF-5: IRF-7
LPS: TLR4_enti_e40
LPS: TLR4
LPS: TLR4: TIRAP_enti_e41
LPS: TLR4: TIRAP
LPS: TLR4: TRAM_enti_e42
LPS: TLR4: TRAM
LPS: TLR4: TIRAP: MyD88_enti_e43
LPS: TLR4: TIRAP: MyD88
LPS: TLR4: TRAM: TRIF_enti_e44
LPS: TLR4: TRAM: TRIF
LPS: TLR4: TRAM: TRIF: RIP1_enti_e45
LPS: TLR4: TRAM: TRIF: RIP1
poly I:C: TLR3_enti_e46
poly I:C: TLR3
poly I:C: TLR3: TRIF_enti_e47
poly I:C: TLR3: TRIF
poly I:C_enti_e48
poly I:C
poly I:C: TLR3: TRIF: RIP1_enti_e49
poly I:C: TLR3: TRIF: RIP1
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5_enti_e63
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5
TLR ligand: TLR: MyD88: IRAK-1{p}: IRAK-4: TRAF6: IRF-5_enti_e65
TLR ligand: TLR: MyD88: IRAK-1{p}: IRAK-4: TRAF6: IRF-5
IRAK-1{p}: TRAF6_enti_e64
IRAK-1{p}: TRAF6
TLR ligand: TLR: MyD88: IRAK-4: IRF-5_enti_e66
TLR ligand: TLR: MyD88: IRAK-4: IRF-5
IRAK-1{p}: TRAF6: TAK1: TAB1: TAB2: Ubc13: Uev1A_enti_e67
IRAK-1{p}: TRAF6: TAK1: TAB1: TAB2: Ubc13: Uev1A
IRAK-1{p}: TRAF6: TAK1 {activated}: TAB1: TAB2: Ubc13: Uev1A_enti_e68
IRAK-1{p}: TRAF6: TAK1 {activated}: TAB1: TAB2: Ubc13: Uev1A
JNK {activated}_enti_e71
JNK {activated}
MAPKs {activated}_enti_e72
MAPKs {activated}
protein ramnents_enti_e74
IKK-alpha:IKK-beta:IKK-gamma {p}_enti_e69
IKK-alpha:IKK-beta:IKK-gamma {p}
NF-kappaB {nucleus}_enti_e75
NF-kappaB {nucleus}
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5 {activated}_enti_e76
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-5 {activated}
IFNbeta_enti_MO000016660
IFNbeta
IFN-beta_enti_G010228
IFN-beta
IFNalpha_enti_e77
IFNalpha
IFNalpha_enti_e79
IFNalpha
ZAP-70_enti_MO000017772
ZAP-70
Lck_enti_MO000000138
Lck
PKCtheta_enti_MO000017433
PKCtheta
antigen-MHC complex_enti_e78
antigen-MHC complex
antigen-MHC complex: TCR: CD3zeta_enti_e80
antigen-MHC complex: TCR: CD3zeta
TCR: CD3zeta_enti_e81
TCR: CD3zeta
antigen-MHC complex: TCR: CD3zeta {p}_enti_e82
antigen-MHC complex: TCR: CD3zeta {p}
antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70_enti_e83
antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70
LAT: SLP-76_enti_e84
LAT: SLP-76
LAT {p}: SLP-76 {p}_enti_e85
LAT {p}: SLP-76 {p}
PLCgamma1_enti_MO000017617
PLCgamma1
LAT {p}: SLP-76 {p}: PLCgamma1_enti_e86
LAT {p}: SLP-76 {p}: PLCgamma1
IP3_enti_MO000000332
IP3
antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70: IRAK-4_enti_e88
antigen-MHC complex: TCR: CD3zeta {p}: ZAP-70: IRAK-4
PKCtheta {p}_enti_e87
PKCtheta {p}
calcineurin_enti_MO000016724
calcineurin
calcineurin {activated}_enti_e89
calcineurin {activated}
NF-AT_enti_MO000017212
NF-AT
NF-AT {activated}_enti_e90
NF-AT {activated}
CBM complex_enti_e91
CBM complex
CBM complex: PKCtheta {p}_enti_e92
CBM complex: PKCtheta {p}
TCR_enti_MO000017777
TCR
PMA_enti_MO000000103
PMA
PMA: TCR_enti_e93
PMA: TCR
PDK1_enti_MO000017142
PDK1
PLCbeta_enti_MO000000133
PLCbeta
PLCgamma2_enti_MO000017704
PLCgamma2
PLCbeta {activated}_enti_e94
PLCbeta {activated}
PLCgamma2 {activated}_enti_e95
PLCgamma2 {activated}
CD25_enti_MO000017214
CD25
Bcl-xL_enti_MO000017151
Bcl-xL
CD25_enti_e96
CD25
Bcl-xL_enti_e97
Bcl-xL
IL10_enti_G011345
IL10
IL-10_enti_MO000017247
IL-10
cytokines_enti_MO000019387
cytokines
chemokines_enti_MO000000265
chemokines
cytokines_enti_e98
cytokines
chemokines_enti_e99
chemokines
Ca_enti_e100
Ca
cyclosporine_enti_e101
cyclosporine
FK506_enti_e102
FK506
Triacyl lipopeptide_enti_e104
Triacyl lipopeptide
Diacyl lipopeptide_enti_e105
Diacyl lipopeptide
IkappaB: NFkappaB_enti_e103
IkappaB: NFkappaB
IkappaB {p}: NFkappaB_enti_e106
IkappaB {p}: NFkappaB
IkappaB {ub}: NFkappaB_enti_e107
IkappaB {ub}: NFkappaB