1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17070092.csml convertedTime:2009.07.01.10:58

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions.
Authors Rico-Bautista E, Flores-Morales A, Fernandez-Perez L.
Affiliation Molecular Endocrinology Group, Department of Molecular Medicine and Surgery,Karolinska Institute, Stockholm, Sweden.
Abstract Cytokine receptors act through a complex signaling network, involving Januskinases (JAKs) and the signal transducers and activators of transcription(STATs), to regulate diverse biological processes which control growth,development, homeostasis and immune function, among others. The JAK/STATsignaling pathway is attenuated via three mechanisms controlling the initiation,magnitude, and duration of the signal: the PIAS proteins, which prevent STATdimerization or DNA interaction, the SHP phosphatases, which dephosphorylateactivating tyrosine phosphorylations, and the suppressors of cytokine signaling(SOCS), which are transcribed in response to cytokine stimulation and useseveral interconnected mechanisms to downregulate the signal. Specific studiestargeting the SOCS genes in vivo have unveiled SOCS2 as the main regulator ofsomatic growth through regulation of GH/IGF-1 signaling. In addition, severalstudies indicate that SOCS2 also has important actions in the central nervoussystem, the regulation of metabolism, the immune response, the mammary glanddevelopment, cancer, and other cytokine-dependent signaling pathways. Consistentwith the role of cytokines in human physiology, any SOCS2 imbalance could resultin a broad range of pathologies such as cardiovascular diseases, insulinresistance, cancer, and severe infections, among others. Thus, determining theimportance of SOCS2 in health and disease will no doubt aid in the developmentof novel therapeutic strategies. In this review, we attempt to summarize theavailable information, including our results, regarding the role of SOCS2 inseveral biological processes.
PMID 17070092
Model Abstract

Entity

G011948:SOCS3 G012586:SOCS2 MO000000071:EGF MO000000090:GM-CSFR MO000000099:GM-CSF MO000000108:EGFR MO000000146:Jak2 MO000007228:IGF-1R MO000011545:PRL MO000013119:STAT1 MO000013122:STAT3 MO000016656:STATs MO000016876:STAT5 MO000017094:IGF-1 MO000017116:CIS MO000017120:SOCS-2 MO000017121:SOCS-3 MO000017247:IL-10 MO000017252:IL-10R MO000017329:GHR MO000017728:PRLR MO000017890:GH MO000018946:elongin C MO000018947:elongin B MO000034588:AhR MO000066172:LEPR e1: e10: e11:GH:GHR e12:STAT5{p} e13:Jak2{p} e14:GH:GHR:SOCS2 e15:GH:GHR{ub}:SOCS2 e16:Degradants e17:IGF-1:IGF-1R e18:IGF-1:IGF-1R e19:STAT3{active} e2: e20:Collagen e21:PRL:PRLR e22:PRL:PRLR;SOCS2 e23:Degradant e24:EGF:EGFR e25:IL-10:IL-10R e26:IFNalpha e27:IFNalphaR e28:IFN-alpha:IFN-alphaR e29:STAT1{active} e3: e30:LEPR:SOCS-2 e31:LEPR:CIS e32:SOCS-2:CIS e33:Lipoxin e34:AhR{active} e35:LXAR{active} e36:LXAR e37:GM-CSF:GM-CSFR e38:procaspase-3 e39:procaspase-2 e4: e40:cytokine e41:cell surface receptor e42:cytokine:cell surface receptor e43:JAK e44:JAK e45:JAK{active} e46:cytokine:cell surface receptor{p} e47:STATs:cytokine:cell surface receptor e48:STATs{p}:cytokine:cell surface receptor e49:STATs{p}:STATs{p}:cytokine:cell surface receptor e5:SOCS-2:elonginB e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:SOCS-2:elonginC e60: e61: e62: e63:STAT{p}:STAT{p} e64:mRNA e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p41 p42 p43 p44 p45 p46 p47 p48 p5 p6 p7 p8 p9
Model Detail
609.0, 773.0
22.0, 22.0

SOCS3

--

G011948

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p25 p36

--

true true true true

csml-variable:Double

m94757

10

false

infinite

0

unit false false false
TRANSFACG011948

--

Go back
649.0, 661.0
22.0, 22.0

SOCS2

--

G012586

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p4 p17 p26 p32 p33 p38

p5

true true true true

csml-variable:Double

m95303

10

false

infinite

0

unit false false false
TRANSFACG012586

--

Go back
733.0, 41.0
22.0, 22.0

EGF

--

MO000000071

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
InterProIPR000033
TRANSPATHMO000000071

--

Go back
136.0, 816.0
24.0, 24.0

GM-CSFR

--

MO000000090

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000090

--

Go back
64.0, 812.0
24.0, 24.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
745.0, 109.0
22.0, 22.0

EGFR

--

MO000000108

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
TRANSPATHMO000000108

--

Go back
574.0, 534.0
20.0, 20.0

Jak2

--

MO000000146

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000146

--

Go back
1017.0, 265.0
22.0, 22.0

IGF-1R

--

MO000007228

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m777

10

false

infinite

0

unit false false false
InterProIPR000463
TRANSPATHMO000007228

--

Go back
1102.0, 646.0
20.0, 20.0

PRL

--

MO000011545

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m1292

10

false

infinite

0

unit false false false
InterProIPR001400
TRANSPATHMO000011545

--

Go back
377.0, 261.0
22.0, 22.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
826.0, 210.0
19.0, 19.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
910.0, 1206.0
20.0, 20.0

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
365.0, 553.0
21.5, 21.5

STAT5

--

MO000016876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p21

true true true true

csml-variable:Double

m1798

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
1089.0, 281.0
22.0, 22.0

IGF-1

--

MO000017094

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m1985

10

false

infinite

0

unit false false false
InterProIPR004825
TRANSPATHMO000017094

--

Go back
210.0, 174.0
20.0, 20.0

CIS

--

MO000017116

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p29

true true true true

csml-variable:Double

m2003

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017116

--

Go back
435.0, 383.0
18.0, 18.0

SOCS-2

--

MO000017120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p1 p2 p6 p7 p8 p13 p14 p15 p18 p19 p21 p27 p29

true true true true

csml-variable:Double

m2004

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017120

--

Go back
382.0, 314.0
20.0, 20.0

SOCS-3

--

MO000017121

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m2005

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017121

--

Go back
531.0, 39.0
17.0, 17.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
508.0, 108.0
22.0, 22.0

IL-10R

--

MO000017252

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m2108

10

false

infinite

0

unit false false false
TRANSPATHMO000017252

--

Go back
1013.0, 573.0
25.0, 25.0

GHR

--

MO000017329

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m2174

10

false

infinite

0

unit false false false
InterProIPR003528
TRANSPATHMO000017329

--

Go back
1018.0, 678.0
20.0, 20.0

PRLR

--

MO000017728

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m2485

10

false

infinite

0

unit false false false
TRANSPATHMO000017728

--

Go back
1096.0, 580.0
24.0, 24.0

GH

--

MO000017890

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m2633

10

false

infinite

0

unit false false false
TRANSPATHMO000017890

--

Go back
295.0, 435.0
18.0, 18.0

elongin C

--

MO000018946

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p19

true true true true

csml-variable:Double

m3558

10

false

infinite

0

unit false false false
InterProIPR001232
TRANSPATHMO000018946

--

Go back
614.0, 386.0
20.5, 20.5

elongin B

--

MO000018947

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p19

true true true true

csml-variable:Double

m3559

10

false

infinite

0

unit false false false
InterProIPR000626
TRANSPATHMO000018947

--

Go back
134.0, 522.0
19.0, 19.0

AhR

--

MO000034588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m13128

10

false

infinite

0

unit false false false
InterProIPR001092
TRANSPATHMO000034588

--

Go back
133.0, 289.0
22.0, 22.0

LEPR

--

MO000066172

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p28

true true true true

csml-variable:Double

m41032

10

false

infinite

0

unit false false false
TRANSPATHMO000066172

--

Go back
109.75, 81.99690800911759
956.4156578518365, 1388.715535200866

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
116.75054467947302, 127.97205776960715
927.3744683094664, 1304.5551135203727

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1013.5, 504.0
20.634948476211356, 39.93860995395747

GH:GHR

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4 p8 p14

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
413.0, 609.0
21.5, 21.5

STAT5{p}

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p21

--

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
502.0, 602.0
20.0, 20.0

Jak2{p}

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000146

--

Go back
1015.5, 451.0
24.802532574784372, 34.6081849880712

GH:GHR:SOCS2

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1019.5, 399.0
24.802532574784372, 34.6081849880712

GH:GHR{ub}:SOCS2

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1017.0, 349.0
21.970132107983922, 21.237794371051123

Degradants

--

e16

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1018.5, 202.0
19.085288313966235, 36.93926770445078

IGF-1:IGF-1R

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12 p13 p15

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1016.5, 300.0
23.232152688566714, 32.41695723986053

IGF-1:IGF-1R

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p12

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
838.0, 258.0
19.0, 19.0

STAT3{active}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
109.75, 81.99690800911759
956.4156578518365, 1388.715535200866

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
796.0, 798.0
39.34256055363323, 20.982698961937714

Collagen

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p14 p15

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1017.5, 724.0
20.19995614996711, 39.096689322516994

PRL:PRLR

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17 p18

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1020.5, 624.0
22.900715727656454, 31.954487061846212

PRL:PRLR;SOCS2

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
537.0, 301.0
21.883974727168294, 21.15450890292935

Degradant

--

e23

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
657.5, 96.0
20.451436088577065, 39.58342468756852

EGF:EGFR

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
435.5, 99.0
17.991010743258055, 34.821311115983335

IL-10:IL-10R

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p24 p25 p26

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
147.0, 36.5
25.151942040652038, 15.510364258402095

IFNalpha

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
159.5, 100.0
25.68014059753954, 39.507908611599305

IFNalphaR

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
309.5, 93.0
20.016443762332816, 38.741504056128036

IFN-alpha:IFN-alphaR

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
469.0, 201.0
22.0, 22.0

STAT1{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
128.8783131570367, 101.12522116615438
918.159031537763, 1350.4589088867936

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
133.5, 352.0
21.14470510852883, 40.925235693926766

LEPR:SOCS-2

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
139.5, 211.0
17.753124314843237, 34.360885770664325

LEPR:CIS

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
306.5, 204.0
19.3681053157807, 23.71604732544576

SOCS-2:CIS

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p28

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
303.0, 591.5
25.83479789103691, 16.79261862917399

Lipoxin

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30 p31

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
138.0, 578.0
19.0, 19.0

AhR{active}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p32

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
InterProIPR001092
TRANSPATHMO000034588

--

Go back
135.5, 650.0
22.070298769771522, 33.95430579964851

LXAR{active}

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31

p33

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
136.5, 711.0
22.070298769771522, 33.95430579964851

LXAR

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
137.5, 896.0
20.607761455821095, 39.885989914492434

GM-CSF:GM-CSFR

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35 p36 p37 p38

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
727.0, 865.0
41.62629757785467, 22.200692041522494

procaspase-3

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
711.0, 981.0
41.62629757785467, 22.200692041522494

procaspase-2

--

e39

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
164.2656924975547, 134.59976919096846
847.3842728567275, 1283.5098128371644

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1097.0, 885.5
22.471322197625273, 13.85731535520225

cytokine

--

e40

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1016.5, 930.0
23.57820738137083, 36.27416520210896

cell surface receptor

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1013.5, 1047.0
21.18548563911423, 41.00416575312432

cytokine:cell surface receptor

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p42 p48

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
765.0, 1127.5
22.72, 17.040000000000003

JAK

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

p48

p41

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
712.0, 1059.5
23.040000000000003, 17.28

JAK

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p48

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
861.0, 1151.5
22.72, 17.040000000000003

JAK{active}

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p41

p42 p44

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1013.5, 1135.0
21.18548563911423, 41.00416575312432

cytokine:cell surface receptor{p}

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42 p46

p43

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1015.5, 1243.0
24.526335107359156, 34.22279317305928

STATs:cytokine:cell surface receptor

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1015.5, 1331.0
24.64470545054138, 34.38796109377867

STATs{p}:cytokine:cell surface receptor

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p45

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1016.5, 1376.0
22.806019453110654, 31.822352725270687

STATs{p}:STATs{p}:cytokine:cell surface receptor

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
668.5, 426.0
22.323946008998494, 27.335444092651226

SOCS-2:elonginB

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
455.0, 621.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
505.29367619468036, 631.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
461.06992643728904, 626.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
461.93705878547314, 627.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
455.0, 621.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
455.0, 621.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
461.93705878547314, 627.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
794.9158804881849, 794.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
718.6082338479803, 915.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
455.0, 621.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
320.5, 494.0
22.323946008998494, 27.335444092651226

SOCS-2:elonginC

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
564.7511016961721, 808.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
564.2586758712023, 787.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
585.4329863449013, 846.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
794.0, 949.0
28.17073170731707, 22.536585365853657

STAT{p}:STAT{p}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p46

p47

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
843.0, 841.0
41.05536332179931, 21.896193771626297

mRNA

--

e64

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
112.0, 89.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
109.0, 123.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
130.26364139235218, 134.09340473576202
892.4367213376764, 1284.6890998863855

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
509.0, 397.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017120 MO000018947

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m2004*m3559*0.1

nodelay

--

true

0

false

PMID: 17070092,15690087 We have also shown that SOCS2 binds Elongin B and C

Go back
938.0, 350.0
19.0, 19.0

p10

p10

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17070092 These results suggest that SOCS2 might act as a ubiquitin ligase, promoting the ubiquitination and degradation of the GH receptor.

Go back
1090.0, 210.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017094 MO000007228

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m1985*m777*0.1

nodelay

--

true

0

false

PMID: 17070092,9727029,10747872 SOCS2 binds the IGF-1 receptor and inhibits IGF-1-induced STAT3 activation

Go back
917.0, 209.0
21.0, 21.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e18 MO000013122

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m17*m1360*0.1

nodelay

--

true

0

false

PMID: 17070092,9727029,10747872 SOCS2 binds the IGF-1 receptor and inhibits IGF-1-induced STAT3 activation

Go back
906.0, 306.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017120 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m2004*m17*0.1

nodelay

--

true

0

false

PMID: 17070092,9727029,10747872 SOCS2 binds the IGF-1 receptor and inhibits IGF

Go back
805.0, 725.0
21.0, 21.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11 MO000017120

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m11*0.1

nodelay

--

true

0

false

PMID:17070092,15831713 Indeed, recent findings have demonstrated that SOCS2 has inhibitory effects on both GH and IGF-1 stimulation of collagen expression in intestinal mesenchymal cells

Go back
649.0, 721.0
21.0, 21.0

p14

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17 MO000017120

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m17*0.1

nodelay

--

true

0

false

PMID:17070092,15831713 Indeed, recent findings have demonstrated that SOCS2 has inhibitory effects on both GH and IGF-1 stimulation of collagen expression in intestinal mesenchymal cells

Go back
1105.0, 733.0
21.0, 21.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000011545 MO000017728

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m1292*m2485*0.1

nodelay

--

true

0

false

PMID: 17070092 SOCS2 expression is induced by PRL in several systems

Go back
698.0, 778.0
19.0, 19.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G012586

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 17070092 SOCS2 expression is induced by PRL in several systems

Go back
793.0, 577.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017120 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m2004*m21*0.1

nodelay

--

true

0

false

PMID: 17070092,10455112 It has also been shown that SOCS2 is able to bind the PRL receptor

Go back
452.0, 280.0
23.0, 23.0

p19

p19

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

MO000017121 MO000017120 MO000018947 MO000018946

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c53 : 1

m2005*m2004*m3559*m3558*0.1

nodelay

--

true

0

false

PMID: 17070092,16199887 Similar studies show that SOCS2 enhances IL-2 and IL-3-dependent signaling through the degradation of SOCS3 PMID: 17070092 The degradation of SOCS3 by SOCS2 is enhanced by coexpression with Elongin BC and requires an intact SOCS box, suggesting that SOCS2 acts as a ubiquitin ligase towards SOCS3.

Go back
369.0, 433.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017120 MO000018946

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m2004*m3558*0.1

nodelay

--

true

0

false

PMID: 17070092,15690087 We have also shown that SOCS2 binds Elongin B and C

Go back
662.0, 42.0
22.0, 22.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000071 MO000000108

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m63*m96*0.1

nodelay

--

true

0

false

PMID: 17070092,9266833,12396724,14764607 SOCS2 is able to downregulate the apoptotic effect of LIF in M1 cells , to block the EPO-dependent reporter activity and cell proliferation, and to decrease EGF-dependent STAT5 phosphorylation in PC12 cells

Go back
657.0, 293.0
21.0, 21.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016876 e24 MO000017120

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c60 : 1

m1798*m24*0.1

nodelay

--

true

0

false

PMID: 17070092,9266833,12396724,14764607 SOCS2 is able to downregulate the apoptotic effect of LIF in M1 cells , to block the EPO-dependent reporter activity and cell proliferation, and to decrease EGF-dependent STAT5 phosphorylation in PC12 cells

Go back
463.0, 39.0
19.0, 19.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017247 MO000017252

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m2103*m2108*0.1

nodelay

--

true

0

false

PMID: 17070092 It has been shown that IL-10 inhibits IFN-alpha-dependent STAT1 activation, but up regulates SOCS2 and SOCS3 in liver.

Go back
217.0, 33.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m26*m27*0.1

nodelay

--

true

0

false

PMID: 17070092 It has been shown that IL-10 inhibits IFN-alpha-dependent STAT1 activation, but up regulates SOCS2 and SOCS3 in liver.

Go back
377.0, 201.0
21.0, 21.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e25 MO000013119

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m28*m1357*0.1

nodelay

--

true

0

false

PMID: 17070092 It has been shown that IL-10 inhibits IFN-alpha-dependent STAT1 activation, but up regulates SOCS2 and SOCS3 in liver.

Go back
562.0, 702.0
19.0, 19.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e25

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 17070092 It has been shown that IL-10 inhibits IFN-alpha-dependent STAT1 activation, but up regulates SOCS2 and SOCS3 in liver.

Go back
713.0, 673.0
21.0, 21.0

p25

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e25

G012586

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 17070092 It has been shown that IL-10 inhibits IFN-alpha-dependent STAT1 activation, but up regulates SOCS2 and SOCS3 in liver.

Go back
221.0, 289.0
17.0, 17.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066172 MO000017120

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m41032*m2004*0.1

nodelay

--

true

0

false

PMID: 17070092 A recent study has also shown that SOCS2, as well as CIS, is able to bind the leptin receptor (LR) through specific phosphorylated tyrosines: Y985 and Y1077 for CIS and Y1077 for SOCS2.

Go back
211.0, 235.0
19.0, 19.0

p27

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017116 MO000066172 e32

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c86 : 1
stoichiometry:c82 : 1

m2003*m41032*0.1

nodelay

--

true

0

false

PMID: 17070092 A recent study has also shown that SOCS2, as well as CIS, is able to bind the leptin receptor (LR) through specific phosphorylated tyrosines: Y985 and Y1077 for CIS and Y1077 for SOCS2. PMID: 17070092,16684815 Interestingly, SOCS2 can block the access of CIS to Y985 on the receptor through interaction with the SOCS box of CIS, suggesting that SOCS2 might act as a ubiquitin ligase towards CIS

Go back
291.0, 275.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017116 MO000017120

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m2003*m2004*0.1

nodelay

--

true

0

false

PMID: 17070092,16684815 Interestingly, SOCS2 can block the access of CIS to Y985 on the receptor through interaction with the SOCS box of CIS, suggesting that SOCS2 might act as a ubiquitin ligase towards CIS

Go back
1097.0, 513.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017329 MO000017890

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m2174*m2633*0.1

nodelay

--

true

0

false

PMID: 17070092,10433229,9430658,10998044 GH induces the expression of several members of the SOCS family, including SOCS2

Go back
206.0, 546.0
19.0, 19.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000034588 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m13128*m33*0.1

nodelay

--

true

0

false

PMID: 17070092,16415877 SOCS2 mRNA and protein were induced by lipoxin (LXA4), an eicosanoid mediator with potent anti-inflammatory properties, by activation of two receptors, AhR and LXAR, in dendritic cells (DC)

Go back
218.0, 678.0
19.0, 19.0

p30

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c91 : 1

m36*m33*0.1

nodelay

--

true

0

false

PMID: 17070092,16415877 SOCS2 mRNA and protein were induced by lipoxin (LXA4), an eicosanoid mediator with potent anti-inflammatory properties, by activation of two receptors, AhR and LXAR, in dendritic cells (DC)

Go back
516.0, 752.0
24.0, 24.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e34

G012586

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17070092,16415877 SOCS2 mRNA and protein were induced by lipoxin (LXA4), an eicosanoid mediator with potent anti-inflammatory properties, by activation of two receptors, AhR and LXAR, in dendritic cells (DC)

Go back
513.0, 817.0
21.0, 21.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G012586

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17070092,16415877 SOCS2 mRNA and protein were induced by lipoxin (LXA4), an eicosanoid mediator with potent anti-inflammatory properties, by activation of two receptors, AhR and LXAR, in dendritic cells (DC)

Go back
65.0, 873.0
21.0, 21.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000099 MO000000090

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m88*m81*0.1

nodelay

--

true

0

false

PMID: 17070092 In acute myeloid leukemia cells, GM-CSF stimulates SOCS2, SOCS3, and procaspase 2 and 3 expression.

Go back
565.0, 917.0
19.0, 19.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m37*0.1

nodelay

--

true

0

false

Go back
578.0, 886.0
19.0, 19.0

p35

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m37*0.1

nodelay

--

true

0

false

Go back
594.0, 958.0
19.0, 19.0

p35

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m37*0.1

nodelay

--

true

0

false

Go back
634.0, 834.0
19.0, 19.0

p35

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G012586

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m37*0.1

nodelay

--

true

0

false

Go back
1098.0, 938.0
19.0, 19.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m40*m41*0.1

nodelay

--

true

0

false

PMID: 17070092 Cytokine receptors act through a complex signaling network, involving Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs), to regulate diverse biological processes which control growth, development, homeostasis and immune function, among others.

Go back
713.0, 709.0
22.0, 22.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11

G012586

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17070092,10433229,9430658,10998044 GH induces the expression of several members of the SOCS family, including SOCS2

Go back
809.0, 1181.0
21.0, 21.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e43

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17070092 This process involves oligomerization and activation of the JAK family of tyrosine kinases, which in turn phosphorylate the receptor at specific tyrosine residues.

Go back
925.0, 1097.0
21.0, 21.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e42 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m42*m45*0.1

nodelay

--

true

0

false

PMID: 17070092 This process involves oligomerization and activation of the JAK family of tyrosine kinases, which in turn phosphorylate the receptor at specific tyrosine residues.

Go back
914.0, 1146.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e46 MO000016656

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m46*m1633*0.1

nodelay

--

true

0

false

PMID: 17070092 STAT proteins are then recruited to these phosphorylated sites and are phosphorylated at tyrosine amino acids by the action of JAK proteins

Go back
914.0, 1286.0
19.0, 19.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e47 e45

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m47*m45*0.1

nodelay

--

true

0

false

PMID: 17070092 STAT proteins are then recruited to these phosphorylated sites and are phosphorylated at tyrosine amino acids by the action of JAK proteins

Go back
857.0, 1337.0
21.0, 21.0

p45

p45

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c125 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17070092,15020666 Dimerization of the phosphorylated STATs leads to nuclear migration and regulation of gene expression

Go back
597.0, 1061.0
21.0, 21.0

p46

p46

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e49

e63 e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17070092,15020666 Dimerization of the phosphorylated STATs leads to nuclear migration and regulation of gene expression

Go back
797.0, 893.0
21.0, 21.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17070092,15020666 Dimerization of the phosphorylated STATs leads to nuclear migration and regulation of gene expression

Go back
801.0, 1061.0
21.0, 21.0

p48

p48

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e42 e44

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m42*m44*0.1

nodelay

--

true

0

false

PMID: 17070092 This process involves oligomerization and activation of the JAK family of tyrosine kinases, which in turn phosphorylate the receptor at specific tyrosine residues.

Go back
586.0, 574.0
19.0, 19.0

p5

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G012586

MO000017120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m95303*0.1

nodelay

--

true

0

false

PMID: 17070092,15125881 SOCS2 overexpression in vitro shows a partial inhibition of GH-dependent signaling (e.g. phosphorylation of STAT5 and JAK2, DNA-binding capacity of STAT5 and GH-dependent reporter activity), in contrast to SOCS1 and SOCS3, which have a stronger inhibitory action

Go back
433.0, 537.0
21.0, 21.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016876 MO000017120

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1
stoichiometry:c15 : 1

m1798*0.1

nodelay

--

true

0

false

PMID: 17070092,15125881 SOCS2 overexpression in vitro shows a partial inhibition of GH-dependent signaling (e.g. phosphorylation of STAT5 and JAK2, DNA-binding capacity of STAT5 and GH-dependent reporter activity), in contrast to SOCS1 and SOCS3, which have a stronger inhibitory action

Go back
502.0, 534.0
20.0, 20.0

p6

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000146 MO000017120

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c19 : 1
stoichiometry:c18 : 1

m130*0.1

nodelay

--

true

0

false

PMID: 17070092,15125881 SOCS2 overexpression in vitro shows a partial inhibition of GH-dependent signaling (e.g. phosphorylation of STAT5 and JAK2, DNA-binding capacity of STAT5 and GH-dependent reporter activity), in contrast to SOCS1 and SOCS3, which have a stronger inhibitory action PMID: 17070092,1058543 It has also been shown that SOCS2 can inhibit JAK2 tyrosine phosphorylation even in the absence of the GH receptor

Go back
738.0, 514.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017120 e11

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m2004*m11*0.1

nodelay

--

true

0

false

PMID: 17070092 SOCS2 is able to bind the GH receptor through tyrosines Y595 and Y487

Go back
930.0, 406.0
19.0, 19.0

p9

p9

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 17070092 These results suggest that SOCS2 might act as a ubiquitin ligase, promoting the ubiquitination and degradation of the GH receptor.

Go back
453.0, 394.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.7004069668477, 531.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 916.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.0, 884.2544243629187

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 896.3805211953236

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.0, 802.6921915811266

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 917.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 970.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 846.1639519239586

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
645.0, 690.9658356465832

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.0, 899.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.0, 948.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.36345376026, 684.8483457221029

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1039.5785216249326, 957.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 1145.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 1171.1804964634343

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.2792613278383, 1073.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0, 1122.121475197316

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
946.0, 1113.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.0, 1156.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.6769518923717, 599.4904638506382

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
921.0, 1172.990498808999

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 1165.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.5522843369631, 1264.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 1300.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
875.0, 1169.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
878.0, 1351.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.0, 1348.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.371143262825, 1084.8382366131227

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 971.8918853797064

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.0, 1074.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
455.9665520521821, 407.27163142355846

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.0, 922.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.0, 868.4829175920399

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.9982644538248, 1068.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.0, 1068.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.8201065633589, 1082.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 552.8605857057737

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.11773585424936, 558.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0, 401.0

c16

c16

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
530.0, 544.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 554.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.0, 401.0

c19

c19

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
537.9439061935595, 397.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 396.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.0, 524.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 471.5747524373527

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.8689728952183, 425.10087934042883

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.0, 416.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
963.6564023547028, 370.4376015698018

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 360.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 237.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.0, 232.8596008605664

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.0, 220.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 410.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
946.0, 220.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
453.0, 319.2727631728259

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
931.0923151175666, 228.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 316.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.9009143783599, 232.75403263768337

c34

c34

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
845.0, 220.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.8599434057004, 227.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.6119012316099, 535.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
816.0, 746.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 400.0

c39

c39

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
396.17940388792766, 399.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
672.6712819211917, 233.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
670.0, 737.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 401.0

c42

c42

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1112.0, 666.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.0, 694.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.0, 744.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.9232391629239, 745.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0381604823071, 690.4006473286968

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 397.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.5659293056267, 599.5704017715636

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 444.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.0, 590.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.0, 300.3432448658572

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 310.8446454055274

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 295.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.71526480281614, 303.3480131816795

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 308.5088987746754

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
691.9983345477076, 52.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.2369628809572, 67.01001936339188

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.4990262892414, 64.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 319.32724755403876

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.8, 454.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.892190663057, 314.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 136.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
453.0, 309.4603501152738

c62

c62

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
489.99833454770754, 48.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.4067376666459, 64.6768752524938

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.21592049628157, 58.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.0, 44.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
185.0, 60.4

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.0, 51.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.0, 126.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1038.0, 536.8515934073898

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.03655065603033, 130.0

c70

c70

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
388.0, 230.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.0, 212.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.0, 134.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.0, 721.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 134.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.8587085313798, 675.49689686312

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
155.0, 298.24231301312614

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.33181884522978, 305.200692490811

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
161.05458406215328, 306.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.0, 542.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.0, 194.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 256.64990554975276

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
164.77778909726223, 231.87243070860018

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
228.0, 194.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.4184376420474, 296.77531760568326

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 235.82484743187868

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
233.83267237267404, 219.0

c86

c86

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
153.0, 535.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
164.24189555258423, 561.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
232.3335677176674, 563.1966833641114

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1042.0, 524.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 696.6259734110107

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.76114000116266, 671.9402850002907

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
242.65685424949237, 608.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 672.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
534.0, 689.0484903342966

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
157.0, 592.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.0, 684.5755691246206

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
76.0, 836.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
92.30801844814233, 837.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
86.0, 888.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back