PMID: 17142025, 16849464 In human DCs, LPS-induced prostaglandin E2 (PGE2) production appeared to be crucial because podosome loss was blocked by indomethacin and triggered by addition of PGE2

PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC

PMID: 17142025, 16785530 A clue as to how MHC class II traffic might be regulated in DCs came from a demonstration that transgenic or in vitro overexpression of the E3-ligase cMIR leads to down-regulation of MHC class II molecules through ubiquitination of lysine 225 in the ¦Â chain PMID: 17142025, 17174123, 17051151 Two new studies show that this residue is oligo-ubiquitinated in immature DCs but not in mature DCs

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

PMID: 17142025,15860593 A recent study on the Toxoplasma gondii parasite suggests that it can. T. gondii profilin, a ligand for TLR11 is immunodominant in the CD4 T-cell response

PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules

PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC

PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC