1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17142025.csml convertedTime:2009.07.01.10:59

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Proximal effects of Toll-like receptor activation in dendritic cells.
Authors Watts C, Zaru R, Prescott AR, Wallin RP, West MA.
Affiliation Division of Cell Biology and Immunology, College of Life Sciences, University ofDundee, Dundee DD1 5EH, United Kingdom. c.watts@dundee.ac.uk
Abstract Toll-like receptor (TLR) signals induce dendritic cell (DC) differentiation andinfluence the immunological outcome of their interactions with T cells. Recentin vitro studies demonstrate that TLR signals also trigger strikingreorganisation of the DC vacuolar compartments, the cytoskeleton and themachinery of protein translation and turnover. Moreover, TLR ligation withinendosomes and phagosomes appears to establish organelle autonomous signals.These changes, which mostly occur within minutes to a few hours after TLRengagement, are adaptations relevant to the antigen capture, processing andmigratory phases of the DC life history.
PMID 17142025
Model Abstract

Entity

MO000016882:LPS e1: e10: e11:MARCO e12:fascin e13:fascin e14:marco e15:profilin:TLR11 e16:TLR11 e17:profilin e18: e19: e2: e20: e21:TLR9 e22:CpG-A:TLR9 e23:CpG-A e24:type I interferon e25:type I interferon e26:IRF-7 e27:MYD88 e28:CpG-A:TLR9:MYD88:IRF-7 e29:MHC class II beta chain {ub}n e3: e30:MHC class II beta chain e31:cMIR e32:MHC class II beta chain e33:MHC class II beta chain e34:MHC class I e35:MHC class I e4: e5:PGE2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR ligand:TLR e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
639.0, 167.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false

--

Go back
197.8942221846428, 237.98291538411468
873.3413925080401, 1268.0917019216738

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
206.30880569269465, 257.36510986514185
846.5352496015231, 1190.837063539246

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
640.0, 1163.6159169550174
47.595155709342556, 25.3840830449827

MARCO

--

e11

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p2

p5

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
549.0, 1071.6124567474048
45.72664359861592, 24.387543252595158

fascin

--

e12

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
307.0, 919.6600000000001
33.120000000000005, 24.840000000000003

fascin

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1114.5, 1040.3848857644991
19.899824253075572, 30.61511423550088

marco

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
498.5, 248.83731637798724
19.7173865380399, 38.16268362201272

profilin:TLR11

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
344.5, 253.44463971880486
23.7609841827768, 36.55536028119508

TLR11

--

e16

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
410.0, 132.19595782073813
35.85237258347979, 23.304042179261867

profilin

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
369.0, 471.1357404281951
149.22917338289088, 249.1368403087246

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
369.0, 471.1357404281951
149.22917338289088, 249.1368403087246

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
197.8942221846428, 237.98291538411468
873.3413925080401, 1268.0917019216738

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
369.0, 471.1357404281951
149.22917338289088, 249.1368403087246

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
391.5, 456.9490333919156
25.383128295254835, 39.05096660808435

TLR9

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
463.5, 479.21793466345105
17.454067090550318, 33.782065336549

CpG-A:TLR9

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
366.0, 370.92106659591406
53.441231095781376, 11.578933404085964

CpG-A

--

e23

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
558.0, 1222.1591695501734
40.951557093425606, 21.840830449826992

type I interferon

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p8

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
300.5, 1021.543771382572
23.098007647413965, 37.45622861742805

type I interferon

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
604.0, 465.02993451824125
16.45369504209541, 37.97006548175865

IRF-7

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
557.0, 384.0222378748239
38.072046689474746, 23.477762125176096

MYD88

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
489.0, 512.9117647058823
22.85294117647059, 38.088235294117645

CpG-A:TLR9:MYD88:IRF-7

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
768.0, 643.9237228831352
32.70818754373688, 25.076277116864937

MHC class II beta chain {ub}n

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
215.3610500348035, 255.4497432342755
838.4077368077187, 1233.1580462213535

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
810.0, 462.93449386194413
28.48460454819883, 17.565506138055948

MHC class II beta chain

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
926.0, 533.9859681945743
19.506080449017773, 45.01403180542563

cMIR

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
751.0, 1237.1038062283737
41.05536332179931, 21.896193771626297

MHC class II beta chain

--

e32

cso30:c:mRNA

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1024.5, 1202.8047896961161
30.953713020728514, 50.195210303884075

MHC class II beta chain

--

e33

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
694.0, 1306.006920415225
48.73702422145329, 25.993079584775085

MHC class I

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1023.5, 1335.5349164821898
25.570134835983094, 41.46508351781044

MHC class I

--

e35

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
247.67468155760122, 286.0166919720569
773.7804737621237, 1172.0241487457888

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
622.0, 535.0
60.0, 34.0

PGE2

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
382.76007198275397, 969.2898721221442
474.93956457557607, 430.71800362813025

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
434.05708268179166, 979.4972626426448
277.71140274996446, 417.4515353438962

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
388.9510905153965, 975.0386750453121
462.557527510291, 419.2203977817941

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
389.8355217343454, 975.9231062642612
460.78866507239314, 417.4515353438962

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
382.76007198275397, 969.2898721221442
474.93956457557607, 430.71800362813025

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
382.76007198275397, 969.2898721221442
474.93956457557607, 430.71800362813025

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
389.8355217343454, 975.9231062642612
460.78866507239314, 417.4515353438962

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
729.4571098107344, 1146.1761159119299
29.671614437309568, 26.860619385354003

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
651.6271625432291, 1269.9964865647803
84.0209658001484, 76.06108482960823

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
382.76007198275397, 969.2898721221442
474.93956457557607, 430.71800362813025

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1029.5, 536.8243806182854
20.24073668055251, 39.17561938171453

TLR ligand:TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p2 p3 p4 p5

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
494.700655052226, 1160.6973938823216
15.040638159723251, 7.241788743570466

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
494.198405570319, 1139.1006661603396
51.480571895423594, 92.66502941176262

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
515.795133292302, 1199.370603989129
8.035991710505138, 8.035991710505158

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
209.36865424107725, 243.0858166393567
856.4758177005774, 1213.6041106901173

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
212.42850278945974, 264.50475647803444
821.6274574893354, 1193.0030682745162

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
220.58809891847986, 285.92369631671215
817.8762774549776, 1177.357131973615

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
642.0, 422.0
19.0, 19.0

p1

p1

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17142025, 16849464 In human DCs, LPS-induced prostaglandin E2 (PGE2) production appeared to be crucial because podosome loss was blocked by indomethacin and triggered by addition of PGE2

Go back
543.0, 475.0
17.0, 17.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m22*m27*m26*0.1

nodelay

--

true

0

false

PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC

Go back
809.0, 545.0
21.0, 21.0

p11

p11

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m30*m31*0.1

nodelay

--

true

0

false

PMID: 17142025, 16785530 A clue as to how MHC class II traffic might be regulated in DCs came from a demonstration that transgenic or in vitro overexpression of the E3-ligase cMIR leads to down-regulation of MHC class II molecules through ubiquitination of lysine 225 in the ¦Â chain PMID: 17142025, 17174123, 17051151 Two new studies show that this residue is oligo-ubiquitinated in immature DCs but not in mature DCs

Go back
762.0, 1150.0
19.0, 19.0

p12

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c31 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

Go back
922.0, 1174.0
19.0, 19.0

p13

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c39 : 1
stoichiometry:c32 : 1

m32*m155666*0.1

nodelay

--

true

0

false

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

Go back
582.0, 1290.0
19.0, 19.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c36 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

Go back
846.0, 1310.0
19.0, 19.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c40 : 1
stoichiometry:c34 : 1

m34*m155666*0.1

nodelay

--

true

0

false

PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs

Go back
698.0, 1050.0
19.0, 19.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c6 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

Go back
565.0, 1001.0
21.0, 21.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c5 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

Go back
402.0, 950.0
19.0, 19.0

p4

p4

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c12 : 1
stoichiometry:c4 : 1

m12*m6*0.1

nodelay

--

true

0

false

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

Go back
873.0, 1048.0
19.0, 19.0

p5

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m11*m6*0.1

nodelay

--

true

0

false

PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.

Go back
417.0, 201.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m17*m16*0.1

nodelay

--

true

0

false

PMID: 17142025,15860593 A recent study on the Toxoplasma gondii parasite suggests that it can. T. gondii profilin, a ligand for TLR11 is immunodominant in the CD4 T-cell response

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466.0, 398.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m23*m21*0.1

nodelay

--

true

0

false

PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules

Go back
573.0, 1145.0
21.0, 21.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c19 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC

Go back
307.0, 1175.5
17.5, 17.5

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c21 : 1

m24*m28*0.1

nodelay

--

true

0

false

PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC

Go back
652.0, 193.0

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.4020640415291, 572.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.7080443324877, 566.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
427.73194077371267, 563.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.0, 156.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 226.13378106138947

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.0, 219.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 383.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
417.0, 422.4792800701431

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.38664441138656, 417.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.5699763999032, 1166.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 441.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.0, 551.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.2050608063404, 1066.9973714472758

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.8671501656995, 1187.451877498391

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.1798705255441, 551.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
481.0, 486.273859510597

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.15283629483, 407.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 484.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.8421713081511, 492.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
821.3745886903887, 481.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.7029180288541, 566.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.3148177390106, 971.9115249081194

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
838.0, 556.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.0, 1169.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.0, 1188.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 1190.9711254108329

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.0, 1322.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.0, 1319.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.0, 1301.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 193.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
593.4223817917494, 193.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
656.0, 193.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.6136689420844, 939.456022239382

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 193.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
573.319744306791, 1022.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.8348598869137, 1069.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 1066.8175689999237

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
892.0, 1056.0717459935026

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.3935657773943, 576.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back