Original Literature | Model OverView |
---|---|
Publication
Title
Sensing of bacteria: NOD a lonely job.
Affiliation
Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, F-75724 ParisCedex 15, France.
Abstract
Recognition of bacteria by the vertebrate innate immune system relies ondetection of invariant molecules by specialized receptors. The view is emergingthat activation of both Toll-like receptors (TLRs) and Nod-like receptors (NLRs)by different bacterial agonists is important in order to mount an inflammatoryresponse in the host. Priming of cells with peptidoglycan and products that aresensed by cytosolic-localized members of the NLR family have a synergisticeffect on TLR signalling and vice versa. Currently, the underlying molecularmechanisms of this cross-talk between NLR and TLR signalling are beginning toemerge. These reveal that the two sensing-systems are non-redundant in bacterialrecognition and that their cross-talk plays an important role in immunologicalhomeostasis.
PMID
17161646
|
Entity
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m75
10
infinite
0
TRANSPATH | MO000000058 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
IKK-gamma
--
MO000016599
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1593
10
infinite
0
InterPro | IPR007087 |
TRANSPATH | MO000016599 |
--
Caspase-1{active}
--
MO000016828
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1765
10
infinite
0
TRANSPATH | MO000016828 |
--
RIP2
--
MO000017949
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2684
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000017949 |
--
proIL-1beta
--
MO000019449
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m4012
10
infinite
0
InterPro | IPR003297 |
TRANSPATH | MO000019449 |
--
Nod2
--
MO000020461
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4947
10
infinite
0
TRANSPATH | MO000020461 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
MDP:Nod2
--
e11
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
TLRs ligand
--
e13
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
TLRs ligand: TLRs
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
TLRs ligand: TLRs:MYD88
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
MDP:Nod2:RIP2
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
DAP:Nod1:RIP2
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
Ikk-gamma{ub}
--
e22
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m22
0
infinite
0
--
DAP:Nod1:caspase1
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
DAP:Nod1:caspase-2
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
DAP:Nod1:caspase-4
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
DAP:Nod1:caspase-8
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m28
0
infinite
0
--
DAP:Nod1:caspase-9
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m29
0
infinite
0
--
NALP3
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
cardinal
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
ASC
--
e31
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
MDP:NALP3
--
e32
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m33
0
infinite
0
--
inflammosome
--
e33
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m34
0
infinite
0
--
csml-variable:Double
m36
0
infinite
0
--
bacterial RNA:NALP3
--
e36
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m37
0
infinite
0
--
lipopolysacharides
--
e37
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m38
0
infinite
0
--
lipopolysaccharides:NALP3
--
e38
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m39
0
infinite
0
--
uric acid crystals:NALP3
--
e39
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m40
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
uric acid crystals
--
e40
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m41
0
infinite
0
--
bacterial toxins: NALP3
--
e41
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m42
0
infinite
0
--
bacterial toxin
--
e42
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m43
0
infinite
0
--
ATP
--
e43
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m44
0
infinite
0
--
P2X7
--
e44
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m45
0
infinite
0
--
P2X7{active}
--
e45
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m46
0
infinite
0
--
IPAF
--
e46
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m47
0
infinite
0
--
IPAF{active}
--
e47
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m48
0
infinite
0
--
TNF-alpha:TNFR
--
e48
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m49
0
infinite
0
--
IFN-gamma
--
e49
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m63
0
infinite
0
--
DAP
--
e5
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
DAP:Nod1
--
e6
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
IFN-gammaR
--
e63
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m64
0
infinite
0
--
IFN-gamma:IFN-gammaR
--
e64
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m65
0
infinite
0
--
Nod2:IPAF
--
e65
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m66
0
infinite
0
--
NALP1
--
e66
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m67
0
infinite
0
--
Nod2:NALP1
--
e67
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m68
0
infinite
0
--
Nod2 splice variant
--
e68
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m69
0
infinite
0
--
Nod2:Nod2 splice variant
--
e69
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m70
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
GRIM19
--
e70
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m71
0
infinite
0
--
GRIM19:Nod2
--
e71
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m72
0
infinite
0
--
erbin:nod2
--
e72
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m73
0
infinite
0
--
MDP:Nod2:TAK1
--
e73
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m74
0
infinite
0
--
NF-kappaB{active}
--
e74
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m76
10
infinite
0
TRANSPATH | MO000000058 |
--
RIP2:TRAF6
--
e75
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m77
0
infinite
0
--
RIP2:caspase1
--
e76
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m78
0
infinite
0
--
MDP:NOD2:RIP2:TRIP6
--
e77
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m79
0
infinite
0
--
NIK:Nod2:MDP
--
e78
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m80
0
infinite
0
--
NLRs
--
e79
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m81
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m5*m4923*0.1
nodelay
--
0
PMID: 17161646 The minimal active structures recognized by Nod1 and Nod2 are d-Glu-meso-diaminopimelic acid (DAP) dipeptide and GlcNAc-MurNAc-l-alanine-d-glutamate (MDP), respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m2684*m6*0.1
nodelay
--
0
PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1
m1593*m20*0.1
nodelay
--
0
PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1
m1593*m21*0.1
nodelay
--
0
PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).
p13
p13
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1
m23*m6*0.1
nodelay
--
0
PMID: 17161646, 11463746 Bacterial activation of Nod1 can also activate Jun N-terminal kinase (JNK), by a yet to be identified mechanism.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m1765*m6*0.1
nodelay
--
0
PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
m6*m1824*0.1
nodelay
--
0
PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m6*m2379*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
m1815*m6*0.1
nodelay
--
0
PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m1891*m6*0.1
nodelay
--
0
PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).
p19
p19
cso30:i:ME_Cleavage
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c64 : 1
stoichiometry:c56 : 1
m4012*m1765*0.1
nodelay
--
0
PMID: 17161646 The generation of IL-1¦Â involves cleavage of a precursor by caspase-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m4947*m12*0.1
nodelay
--
0
PMID: 17161646 The minimal active structures recognized by Nod1 and Nod2 are d-Glu-meso-diaminopimelic acid (DAP) dipeptide and GlcNAc-MurNAc-l-alanine-d-glutamate (MDP), respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c59 : 1
stoichiometry:c141 : 1
stoichiometry:c61 : 1
m31*m32*m81*0.1
nodelay
--
0
PMID: 17161646, 16823444 caspase-1 is activated by a protein complex called the inflammasome. This complex is composed of NLRs from the NALP-family that are characterized by a Pyrin domain, and the adaptor-proteins apoptosis-associated speck-like protein (ASC) and Cardinal. Nalp3, plays a pivotal role in the activation of IL-1¦Â.
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1
m35*m34*0.1
nodelay
--
0
PMID: 17161646, 16823444 caspase-1 is activated by a protein complex called the inflammasome. This complex is composed of NLRs from the NALP-family that are characterized by a Pyrin domain, and the adaptor-proteins apoptosis-associated speck-like protein (ASC) and Cardinal. Nalp3, plays a pivotal role in the activation of IL-1¦Â.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m30*m12*0.1
nodelay
--
0
PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m30*m36*0.1
nodelay
--
0
PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1
m30*m38*0.1
nodelay
--
0
PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1
m30*m41*0.1
nodelay
--
0
PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c78 : 1
m30*m43*0.1
nodelay
--
0
PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.
p27
p27
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c85 : 1
stoichiometry:c81 : 1
m47*m6485*0.1
nodelay
--
0
PMID: 17161646, 16648853, 15190255, 16648852 IL-1¦Â-converting enzyme protease activating factor (Ipaf; CARD12) is essential for activation of caspase-1, induced by bacterial flagellin.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c84 : 1
stoichiometry:c83 : 1
m45*m44*0.1
nodelay
--
0
PMID: 17161646 For most of these elicitors, co-activation of P2X7 by ATP in the extracellular space appears to be essential.
p29
p29
cso30:i:ME_UnknownActivation
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c58 : 1
stoichiometry:c87 : 1
m35*m48*0.1
nodelay
--
0
PMID: 17161646, 16648853, 15190255, 16648852 IL-1¦Â-converting enzyme protease activating factor (Ipaf; CARD12) is essential for activation of caspase-1, induced by bacterial flagellin.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m3962*m13*0.1
nodelay
--
0
PMID: 17161646, 16822173 Most bacteria simultaneously expose a variety of different PAMPs to the immune system of the host, most of which are recognized by TLRs and specialized receptors at the cell membrane.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
m14*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c90 : 1
m14*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
p32
p32
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
m230*m176*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c93 : 1
m49*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c94 : 1
m65*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1
m64*m63*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c102 : 1
m65*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c104 : 1
m49*0.1
nodelay
--
0
PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
m11*0.1
nodelay
--
0
PMID: 17161646, 12537692 MDP enhances MyD88 expression, which could explain the high sensitivity of TLR responses after peptidoglycan priming.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1
m4947*m47*0.1
nodelay
--
0
PMID: 17161646, 15107016 Heterotypic NACHT-domain interactions were shown for Nod2 with Ipaf and Nalp1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c11 : 1
m14*m1572*0.1
nodelay
--
0
PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1
m4947*m67*0.1
nodelay
--
0
PMID: 17161646, 15107016 Heterotypic NACHT-domain interactions were shown for Nod2 with Ipaf and Nalp1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1
m4947*m69*0.1
nodelay
--
0
PMID: 17161646, 16492792 a splice-variant of Nod2 was shown to interact with Nod2 and interfere with its activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1
m71*m4947*0.1
nodelay
--
0
PMID: 17161646, 16203728, 16714539, 15753091 Negative regulatory functions have been attributed to the gene associated with retinoid-IFN-induced mortality 19 (GRIM-19) and the LRR and PDZ domain protein (LAP) Erbin, which binds the CARD domain of Nod2.
p43
p43
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1
m12851*m4947*0.1
nodelay
--
0
PMID: 17161646, 16203728, 16714539, 15753091 Negative regulatory functions have been attributed to the gene associated with retinoid-IFN-induced mortality 19 (GRIM-19) and the LRR and PDZ domain protein (LAP) Erbin, which binds the CARD domain of Nod2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c123 : 1
stoichiometry:c125 : 1
m18*m11*0.1
nodelay
--
0
PMID: 17161646, 15075345 Nod2 also has been linked to TAK1-mediated signalling, as TAK1 interacts with the LRR of Nod2 and is needed for MDP-induced NF-¦ÊB activation.
p45
p45
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1
m75*m74*0.1
nodelay
--
0
PMID: 17161646, 15075345 Nod2 also has been linked to TAK1-mediated signalling, as TAK1 interacts with the LRR of Nod2 and is needed for MDP-induced NF-¦ÊB activation.
p46
p46
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1
m2684*m183*0.1
nodelay
--
0
PMID: 17161646 This protein kinase not only interacts with NLRs, but also binds to members of the TRAF family, such as TRAF6.
p47
p47
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1
m2684*m1765*0.1
nodelay
--
0
PMID: 17161646, 16585594 caspase-1 can interact with RIP2 through CARD?CARD interactions, which has been suggested to have a role in establishing a balance between activation of the inflammasome and NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1
m36881*m20*0.1
nodelay
--
0
PMID: 17161646, 15657077 activated RIP2 binds thyroid hormone receptor interactor 6 (TRIP6) and small interfering RNA (siRNA)-mediated knock-down of this protein, influences NF-¦ÊB activation mediated both by Nod1 and TLR-2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1
m174*m11*0.1
nodelay
--
0
PMID: 17161646, 16552041 NF-kB-inducing kinase (NIK) also binds Nod2 and can activate the non-canonical NF-¦ÊB pathway in response to MDP.
p5
p5
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1
m184*m15*0.1
nodelay
--
0
PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).
p6
p6
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1
m183*m16*0.1
nodelay
--
0
PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).
p7
p7
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1
m1573*m17*0.1
nodelay
--
0
PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).
p8
p8
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1
m207*m18*0.1
nodelay
--
0
PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m11*m2684*0.1
nodelay
--
0
PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--