1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17161646.csml convertedTime:2009.07.01.10:59

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Sensing of bacteria: NOD a lonely job.
Authors Kufer TA, Sansonetti PJ.
Affiliation Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, F-75724 ParisCedex 15, France.
Abstract Recognition of bacteria by the vertebrate innate immune system relies ondetection of invariant molecules by specialized receptors. The view is emergingthat activation of both Toll-like receptors (TLRs) and Nod-like receptors (NLRs)by different bacterial agonists is important in order to mount an inflammatoryresponse in the host. Priming of cells with peptidoglycan and products that aresensed by cytosolic-localized members of the NLR family have a synergisticeffect on TLR signalling and vice versa. Currently, the underlying molecularmechanisms of this cross-talk between NLR and TLR signalling are beginning toemerge. These reveal that the two sensing-systems are non-redundant in bacterialrecognition and that their cross-talk plays an important role in immunologicalhomeostasis.
PMID 17161646
Model Abstract

Entity

G011136:MYD88 G011266:NOD1 G011270:NOD2 MO000000023:JNK MO000000058:NF-kappaB MO000000203:NIK MO000000205:TNFR MO000000212:TRAF6 MO000000213:IRAK MO000000248:IKK MO000000289:TNF-alpha MO000016573:MyD88 MO000016574:TAK1 MO000016597:IL-1beta MO000016599:IKK-gamma MO000016828:Caspase-1{active} MO000016900:Caspase-8 MO000016909:Caspase-2 MO000016987:Caspase-9 MO000017600:Caspase-4 MO000017949:RIP2 MO000019395:TLRs MO000019449:proIL-1beta MO000020434:Nod1 MO000020461:Nod2 MO000022185:flagellin MO000034305:Erbin MO000061988:TRIP6 e1: e10: e11:MDP:Nod2 e12:MDP e13:TLRs ligand e14:TLRs ligand: TLRs e15:TLRs ligand: TLRs:MYD88 e16:IRAK{active} e17:TRAF6{active} e18:TAK1{active} e19:IKK{active} e2: e20:MDP:Nod2:RIP2 e21:DAP:Nod1:RIP2 e22:Ikk-gamma{ub} e23:JNK{active} e24:DAP:Nod1:caspase1 e25:DAP:Nod1:caspase-2 e26:DAP:Nod1:caspase-4 e27:DAP:Nod1:caspase-8 e28:DAP:Nod1:caspase-9 e29:NALP3 e3: e30:cardinal e31:ASC e32:MDP:NALP3 e33:inflammosome e34:Caspase-1 e35:bacterial RNA e36:bacterial RNA:NALP3 e37:lipopolysacharides e38:lipopolysaccharides:NALP3 e39:uric acid crystals:NALP3 e4: e40:uric acid crystals e41:bacterial toxins: NALP3 e42:bacterial toxin e43:ATP e44:P2X7 e45:P2X7{active} e46:IPAF e47:IPAF{active} e48:TNF-alpha:TNFR e49:IFN-gamma e5:DAP e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:DAP:Nod1 e60: e61: e62: e63:IFN-gammaR e64:IFN-gamma:IFN-gammaR e65:Nod2:IPAF e66:NALP1 e67:Nod2:NALP1 e68:Nod2 splice variant e69:Nod2:Nod2 splice variant e7: e70:GRIM19 e71:GRIM19:Nod2 e72:erbin:nod2 e73:MDP:Nod2:TAK1 e74:NF-kappaB{active} e75:RIP2:TRAF6 e76:RIP2:caspase1 e77:MDP:NOD2:RIP2:TRIP6 e78:NIK:Nod2:MDP e79:NLRs e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p6 p7 p8 p9
Model Detail
439.0, 1043.0
42.0, 42.0

MYD88

--

G011136

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m94021

10

false

infinite

0

unit false false false
TRANSFACG011136

--

Go back
637.0, 937.0
38.0, 38.0

NOD1

--

G011266

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p30 p33 p34

--

true true true true

csml-variable:Double

m94151

10

false

infinite

0

unit false false false
TRANSFACG011266

--

Go back
522.0, 948.0
34.0, 34.0

NOD2

--

G011270

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p31 p36 p37

--

true true true true

csml-variable:Double

m94155

10

false

infinite

0

unit false false false
TRANSFACG011270

--

Go back
509.0, 685.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
802.0, 1154.0
36.0, 36.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
281.0, 825.0
38.0, 38.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
1005.0, 829.0
46.0, 46.0

TNFR

--

MO000000205

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m176

10

false

infinite

0

unit false false false
TRANSPATHMO000000205

--

Go back
912.0, 632.0
32.0, 32.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p46

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
922.0, 454.0
36.0, 36.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
873.0, 765.0
30.0, 30.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1232.0, 912.0
32.0, 32.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
945.0, 405.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
879.0, 687.0
34.0, 34.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
295.0, 1031.0
34.0, 34.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
336.0, 556.0
32.0, 32.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
901.0, 337.0
22.0, 22.0

Caspase-1{active}

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
671.0, 139.0
34.0, 34.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
829.0, 533.0
30.0, 30.0

Caspase-2

--

MO000016909

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m1824

10

false

infinite

0

unit false false false
TRANSPATHMO000016909

--

Go back
742.0, 146.0
36.0, 36.0

Caspase-9

--

MO000016987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1891

10

false

infinite

0

unit false false false
TRANSPATHMO000016987

--

Go back
659.0, 543.0
34.0, 34.0

Caspase-4

--

MO000017600

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m2379

10

false

infinite

0

unit false false false
TRANSPATHMO000017600

--

Go back
641.0, 429.0
30.0, 30.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10 p46 p47

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
999.0, 267.0
41.0, 41.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
295.0, 895.0
34.0, 34.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
684.0, 296.0
40.0, 40.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
489.0, 321.0
38.0, 38.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
736.0, 736.0
32.0, 32.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
918.0, 222.0
36.0, 36.0

Erbin

--

MO000034305

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m12851

10

false

infinite

0

unit false false false
InterProIPR003591
TRANSPATHMO000034305

--

Go back
269.0, 1093.0
38.0, 38.0

TRIP6

--

MO000061988

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m36881

10

false

infinite

0

unit false false false
TRANSPATHMO000061988

--

Go back
184.06168637116824, 4.2084040194639085
871.9477448052845, 1309.0771980578622

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
189.46284218064065, 41.217042830825434
845.1843782057218, 1229.325642711047

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
531.5, 367.0
25.909230431922822, 50.146897610173205

MDP:Nod2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
590.0, 243.0
60.0, 34.0

MDP

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2 p22

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1177.0, 249.21001757469247
45.06151142355009, 29.289982425307564

TLRs ligand

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1014.5, 333.3144047358036
27.737557553168166, 53.68559526419645

TLRs ligand: TLRs

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1019.5, 450.4248485960728
24.778858506147913, 34.57515140392733

TLRs ligand: TLRs:MYD88

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
910.0, 578.0
36.0, 36.0

IRAK{active}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p6

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
964.0, 696.0
32.0, 32.0

TRAF6{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p7

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
955.0, 771.0
34.0, 34.0

TAK1{active}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
953.0, 881.0
30.0, 30.0

IKK{active}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

--

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
184.06168637116824, 4.2084040194639085
871.9477448052845, 1309.0771980578622

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
568.5, 426.6158928243716
31.091943475867133, 43.384107175628564

MDP:Nod2:RIP2

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
716.5, 414.0233070288126
30.799963296017612, 42.976692971187376

DAP:Nod1:RIP2

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
305.0, 690.4114765570329
45.11546536039189, 34.58852344296711

Ikk-gamma{ub}

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11 p12

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
561.0, 753.0
30.0, 30.0

JNK{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
939.5, 297.2284822903285
32.086254358597905, 44.7715177096715

DAP:Nod1:caspase1

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
765.5, 595.9172325197284
29.442650027527982, 41.08276748027161

DAP:Nod1:caspase-2

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
663.5, 474.40282620664357
24.794641218572217, 34.59717379335658

DAP:Nod1:caspase-4

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
609.5, 163.61993026243346
29.655716645256007, 41.38006973756653

DAP:Nod1:caspase-8

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
833.5, 151.24756836116717
29.205909341163522, 40.75243163883282

DAP:Nod1:caspase-9

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
365.0, 95.53079090360234
38.86898772388811, 23.969209096397666

NALP3

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
201.5006412672739, 22.239770383897316
837.0698350130732, 1273.0144653289963

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
398.5, 218.2165425638962
26.999798752264038, 43.783457436103845

cardinal

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
502.0, 216.8353601496724
20.004677268475206, 46.1646398503274

ASC

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
337.0, 154.58011049723746
30.97790055248619, 34.41988950276242

MDP:NALP3

--

e32

cso30:c:Complex

cso30:i:CC_Extracellular

--

p22

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
448.5, 385.6909524683428
31.75481739768765, 44.309047531657185

inflammosome

--

e33

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
869.0, 469.0
22.0, 22.0

Caspase-1

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p29

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
414.0, 464.5
60.0, 31.0

bacterial RNA

--

e35

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p23

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
326.0, 475.83425414364643
36.14917127071823, 40.165745856353595

bacterial RNA:NALP3

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
274.0, 299.0
60.0, 34.0

lipopolysacharides

--

e37

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
295.5, 372.68521913014496
25.573737710381604, 31.31478086985503

lipopolysaccharides:NALP3

--

e38

cso30:c:Complex

cso30:i:CC_Extracellular

--

p24

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
275.5, 247.90684885852357
33.55940676553907, 41.093151141476426

uric acid crystals:NALP3

--

e39

cso30:c:Complex

cso30:i:CC_Extracellular

--

p25

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
233.76270782506953, 53.794661521655534
772.5457018974822, 1209.9046830534787

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
292.0, 144.58116063919266
39.56265769554247, 22.4188393608074

uric acid crystals

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p25

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
281.0, 430.6353591160221
30.92817679558011, 34.364640883977906

bacterial toxins: NALP3

--

e41

cso30:c:Complex

cso30:i:CC_Extracellular

--

p26

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
398.0, 521.3397813288477
36.459209419680406, 20.66021867115223

bacterial toxin

--

e42

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p26

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
90.0, 321.33877159309026
42.11132437619961, 23.161228406909792

ATP

--

e43

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p28

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
41.0, 465.68112296236666
45.11169249345945, 27.818877037633328

P2X7

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p28

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
61.0, 589.6811229623667
45.11169249345945, 27.818877037633328

P2X7{active}

--

e45

cso30:c:Protein

cso30:i:CC_Extracellular

--

p28

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
562.0, 630.6199999999999
35.839999999999996, 26.88

IPAF

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27 p39

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
800.0, 649.0999999999999
39.2, 29.400000000000002

IPAF{active}

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1012.5, 917.2337206752904
23.645910984433236, 45.7662793247095

TNF-alpha:TNFR

--

e48

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1217.0, 1024.7987697715291
45.69420035149385, 29.701230228471005

IFN-gamma

--

e49

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
797.0, 232.78889823380996
53.313708999158955, 30.211101766190072

DAP

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
389.6325337004863, 798.151647001093
388.23847666594315, 364.05033321573956

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
431.5651810871243, 806.779110652368
227.0146772311103, 352.83728393804745

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
394.6933704540461, 803.0106350214261
378.1168031588238, 354.33235717507284

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
395.4163471331261, 803.758171639939
376.6708498006638, 352.83728393804745

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
389.6325337004863, 798.151647001093
388.23847666594315, 364.05033321573956

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
389.6325337004863, 798.151647001093
388.23847666594315, 364.05033321573956

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
395.4163471331261, 803.758171639939
376.6708498006638, 352.83728393804745

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
673.039391899834, 947.6589707036554
24.255006844196455, 22.703061760245948

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
609.4174441407965, 1052.3140972954495
68.68278451259698, 64.2881491921019

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
389.6325337004863, 798.151647001093
388.23847666594315, 364.05033321573956

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
811.5, 395.82657311992983
25.406270554702914, 49.17342688007017

DAP:Nod1

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
481.1381581831012, 959.9326069095002
12.294942099491914, 6.120885551491814

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
480.7275952645623, 941.678677755553
42.082699150220805, 78.32209136984231

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
498.3818007617285, 992.6198753944752
6.569006696619825, 6.792159685189573

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1008.5, 1007.7398945518453
31.36906854130053, 48.26010544815466

IFN-gammaR

--

e63

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p35

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1006.5, 1102.497917123438
26.092742819557113, 50.502082876562156

IFN-gamma:IFN-gammaR

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
408.5, 653.8861856357274
30.309615064155977, 37.11381436427263

Nod2:IPAF

--

e65

cso30:c:Complex

cso30:i:CC_Extracellular

--

p39

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
602.0, 589.7853692895956
44.942644395250554, 27.714630710404506

NALP1

--

e66

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p40

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
528.5, 568.7363772704549
31.248625229128482, 38.26362272954508

Nod2:NALP1

--

e67

cso30:c:Complex

cso30:i:CC_Extracellular

--

p40

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
638.5, 274.67760112698727
26.098812638357817, 42.32239887301267

Nod2 splice variant

--

e68

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
888.0, 166.52486187845307
31.027624309392266, 34.47513812154696

Nod2:Nod2 splice variant

--

e69

cso30:c:Complex

cso30:i:CC_Extracellular

--

p41

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
195.51780792953969, 9.476234151192562
855.1090834932631, 1252.8285346920848

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
266.0, 735.0999999999999
35.199999999999996, 26.4

GRIM19

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
367.0, 733.2651933701658
33.96132596685082, 37.734806629834246

GRIM19:Nod2

--

e71

cso30:c:Complex

cso30:i:CC_Extracellular

--

p42

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
941.5, 166.66572237960338
28.03966005665722, 34.3342776203966

erbin:nod2

--

e72

cso30:c:Complex

cso30:i:CC_Extracellular

--

p43

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
802.0, 799.1712707182321
36.745856353591165, 40.828729281767956

MDP:Nod2:TAK1

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
942.0, 1158.0
36.0, 36.0

NF-kappaB{active}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
649.5, 686.3557740376605
28.292784535910677, 34.64422596233961

RIP2:TRAF6

--

e75

cso30:c:Complex

cso30:i:CC_Extracellular

--

p46

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
557.0, 142.74585635359108
30.828729281767956, 34.254143646408835

RIP2:caspase1

--

e76

cso30:c:Complex

cso30:i:CC_Extracellular

--

p47

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
407.0, 1177.1470588235293
26.91176470588235, 44.852941176470594

MDP:NOD2:RIP2:TRIP6

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
360.5, 841.2061323112815
30.048325279120146, 36.79386768871855

NIK:Nod2:MDP

--

e78

cso30:c:Complex

cso30:i:CC_Extracellular

--

p49

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
441.0, 151.53079090360234
38.86898772388811, 23.969209096397666

NLRs

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
198.57277367843875, 31.587447170641873
820.3163330785677, 1231.5616540385645

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
206.71934900883625, 53.69866019009118
816.571139046342, 1215.4100315472765

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
814.0, 306.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m4923*0.1

nodelay

--

true

0

false

PMID: 17161646 The minimal active structures recognized by Nod1 and Nod2 are d-Glu-meso-diaminopimelic acid (DAP) dipeptide and GlcNAc-MurNAc-l-alanine-d-glutamate (MDP), respectively.

Go back
690.0, 354.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m2684*m6*0.1

nodelay

--

true

0

false

PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).

Go back
342.0, 641.5
20.5, 20.5

p11

p11

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m1593*m20*0.1

nodelay

--

true

0

false

PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).

Go back
292.0, 628.0
23.0, 23.0

p12

p12

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m1593*m21*0.1

nodelay

--

true

0

false

PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).

Go back
596.0, 688.0
23.0, 23.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m23*m6*0.1

nodelay

--

true

0

false

PMID: 17161646, 11463746 Bacterial activation of Nod1 can also activate Jun N-terminal kinase (JNK), by a yet to be identified mechanism.

Go back
853.0, 309.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m1765*m6*0.1

nodelay

--

true

0

false

PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).

Go back
812.0, 476.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m6*m1824*0.1

nodelay

--

true

0

false

PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).

Go back
716.0, 476.0
24.0, 24.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m6*m2379*0.1

nodelay

--

true

0

false

Go back
677.0, 213.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m1815*m6*0.1

nodelay

--

true

0

false

PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).

Go back
741.0, 229.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m1891*m6*0.1

nodelay

--

true

0

false

PMID: 17161646, 12459189, 10329646 Nod1 physically interacts with caspases involved both in cytokine maturation (caspase-1 and -4) and in apoptosis (caspase-2, -8 and -9).

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300.0, 956.0
23.0, 23.0

p19

p19

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c64 : 1
stoichiometry:c56 : 1

m4012*m1765*0.1

nodelay

--

true

0

false

PMID: 17161646 The generation of IL-1¦Â involves cleavage of a precursor by caspase-1.

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565.0, 313.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m4947*m12*0.1

nodelay

--

true

0

false

PMID: 17161646 The minimal active structures recognized by Nod1 and Nod2 are d-Glu-meso-diaminopimelic acid (DAP) dipeptide and GlcNAc-MurNAc-l-alanine-d-glutamate (MDP), respectively.

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452.0, 232.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c59 : 1
stoichiometry:c141 : 1
stoichiometry:c61 : 1

m31*m32*m81*0.1

nodelay

--

true

0

false

PMID: 17161646, 16823444 caspase-1 is activated by a protein complex called the inflammasome. This complex is composed of NLRs from the NALP-family that are characterized by a Pyrin domain, and the adaptor-proteins apoptosis-associated speck-like protein (ASC) and Cardinal. Nalp3, plays a pivotal role in the activation of IL-1¦Â.

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876.0, 416.0
15.0, 15.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1

m35*m34*0.1

nodelay

--

true

0

false

PMID: 17161646, 16823444 caspase-1 is activated by a protein complex called the inflammasome. This complex is composed of NLRs from the NALP-family that are characterized by a Pyrin domain, and the adaptor-proteins apoptosis-associated speck-like protein (ASC) and Cardinal. Nalp3, plays a pivotal role in the activation of IL-1¦Â.

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549.0, 189.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m30*m12*0.1

nodelay

--

true

0

false

PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.

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405.0, 341.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m30*m36*0.1

nodelay

--

true

0

false

PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.

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373.0, 276.0
19.0, 19.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m30*m38*0.1

nodelay

--

true

0

false

PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.

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350.0, 250.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m30*m41*0.1

nodelay

--

true

0

false

PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.

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348.0, 364.0
23.0, 23.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c78 : 1

m30*m43*0.1

nodelay

--

true

0

false

PMID: 17161646, 16407888, 16407890, 15530394, 16407889, 16546100 Diverse agonists of this protein were described, including MDP, bacterial RNAs, bacterial toxins, lipopolysaccharides and uric-acid crystals.

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747.0, 679.0
17.0, 17.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c85 : 1
stoichiometry:c81 : 1

m47*m6485*0.1

nodelay

--

true

0

false

PMID: 17161646, 16648853, 15190255, 16648852 IL-1¦Â-converting enzyme protease activating factor (Ipaf; CARD12) is essential for activation of caspase-1, induced by bacterial flagellin.

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86.0, 534.0
19.0, 19.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c84 : 1
stoichiometry:c83 : 1

m45*m44*0.1

nodelay

--

true

0

false

PMID: 17161646 For most of these elicitors, co-activation of P2X7 by ATP in the extracellular space appears to be essential.

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905.0, 405.0
21.0, 21.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c58 : 1
stoichiometry:c87 : 1

m35*m48*0.1

nodelay

--

true

0

false

PMID: 17161646, 16648853, 15190255, 16648852 IL-1¦Â-converting enzyme protease activating factor (Ipaf; CARD12) is essential for activation of caspase-1, induced by bacterial flagellin.

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1114.0, 277.5
20.5, 20.5

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3962*m13*0.1

nodelay

--

true

0

false

PMID: 17161646, 16822173 Most bacteria simultaneously expose a variety of different PAMPs to the immune system of the host, most of which are recognized by TLRs and specialized receptors at the cell membrane.

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641.0, 828.0
27.0, 27.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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537.0, 865.0
21.0, 21.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c90 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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1150.0, 918.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m230*m176*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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696.0, 876.0
23.0, 23.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c93 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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713.0, 945.0
21.0, 21.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c94 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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1121.0, 1054.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m64*m63*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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589.0, 1017.0
21.0, 21.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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524.0, 1032.0
23.0, 23.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17161646, 12671897, 16757890 Nod1 and Nod2 mRNA expression is induced by TLR activation and cytokines such as TNF-alpha and IFN-¦Ã.

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445.0, 936.0
27.0, 27.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17161646, 12537692 MDP enhances MyD88 expression, which could explain the high sensitivity of TLR responses after peptidoglycan priming.

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434.0, 594.0
19.0, 19.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m4947*m47*0.1

nodelay

--

true

0

false

PMID: 17161646, 15107016 Heterotypic NACHT-domain interactions were shown for Nod2 with Ipaf and Nalp1.

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1108.0, 408.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c11 : 1

m14*m1572*0.1

nodelay

--

true

0

false

PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).

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564.0, 524.0
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m4947*m67*0.1

nodelay

--

true

0

false

PMID: 17161646, 15107016 Heterotypic NACHT-domain interactions were shown for Nod2 with Ipaf and Nalp1.

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540.0, 276.0
23.0, 23.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m4947*m69*0.1

nodelay

--

true

0

false

PMID: 17161646, 16492792 a splice-variant of Nod2 was shown to interact with Nod2 and interfere with its activation.

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316.0, 772.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m71*m4947*0.1

nodelay

--

true

0

false

PMID: 17161646, 16203728, 16714539, 15753091 Negative regulatory functions have been attributed to the gene associated with retinoid-IFN-induced mortality 19 (GRIM-19) and the LRR and PDZ domain protein (LAP) Erbin, which binds the CARD domain of Nod2.

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1191.0, 307.0
25.0, 25.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m12851*m4947*0.1

nodelay

--

true

0

false

PMID: 17161646, 16203728, 16714539, 15753091 Negative regulatory functions have been attributed to the gene associated with retinoid-IFN-induced mortality 19 (GRIM-19) and the LRR and PDZ domain protein (LAP) Erbin, which binds the CARD domain of Nod2.

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808.0, 736.0
23.0, 23.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c123 : 1
stoichiometry:c125 : 1

m18*m11*0.1

nodelay

--

true

0

false

PMID: 17161646, 15075345 Nod2 also has been linked to TAK1-mediated signalling, as TAK1 interacts with the LRR of Nod2 and is needed for MDP-induced NF-¦ÊB activation.

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861.0, 1205.0
21.0, 21.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m75*m74*0.1

nodelay

--

true

0

false

PMID: 17161646, 15075345 Nod2 also has been linked to TAK1-mediated signalling, as TAK1 interacts with the LRR of Nod2 and is needed for MDP-induced NF-¦ÊB activation.

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739.0, 551.0
25.0, 25.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m2684*m183*0.1

nodelay

--

true

0

false

PMID: 17161646 This protein kinase not only interacts with NLRs, but also binds to members of the TRAF family, such as TRAF6.

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637.0, 357.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m2684*m1765*0.1

nodelay

--

true

0

false

PMID: 17161646, 16585594 caspase-1 can interact with RIP2 through CARD?CARD interactions, which has been suggested to have a role in establishing a balance between activation of the inflammasome and NF-¦ÊB

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354.0, 1114.0
19.0, 19.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m36881*m20*0.1

nodelay

--

true

0

false

PMID: 17161646, 15657077 activated RIP2 binds thyroid hormone receptor interactor 6 (TRIP6) and small interfering RNA (siRNA)-mediated knock-down of this protein, influences NF-¦ÊB activation mediated both by Nod1 and TLR-2.

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408.0, 768.0
24.0, 24.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m174*m11*0.1

nodelay

--

true

0

false

PMID: 17161646, 16552041 NF-kB-inducing kinase (NIK) also binds Nod2 and can activate the non-canonical NF-¦ÊB pathway in response to MDP.

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913.0, 529.0
21.0, 21.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m184*m15*0.1

nodelay

--

true

0

false

PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).

Go back
970.0, 638.0
19.0, 19.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m183*m16*0.1

nodelay

--

true

0

false

PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).

Go back
920.0, 728.0
23.0, 23.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m1573*m17*0.1

nodelay

--

true

0

false

PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).

Go back
956.0, 824.0
23.0, 23.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1

m207*m18*0.1

nodelay

--

true

0

false

PMID: 17161646, 16822173 Most TLRs do activate nuclear factor ¦ÊB (NF-¦ÊB; p65) by binding of MyD88 to the cytoplasmic tail of the receptor (the Toll/IL-1 receptor domain [TIR]) and subsequently triggering IL-1 receptor-associated kinases (IRAKs), TNF receptor-associated factor 6 (TRAF6) and TGF-beta-activated kinase 1 (TAK1).

Go back
601.0, 381.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m11*m2684*0.1

nodelay

--

true

0

false

PMID: 17161646, 15620648 RIP2 interacts with the caspase recruitment domain (CARD) of Nod1 and Nod2 and is essential for peptidoglycan-mediated NF-¦ÊB activation by enabling ubiquitination of Lys285 of NF-¦ÊB essential modulator (NEMO).

Go back
824.0, 263.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.0, 369.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.0566025469539, 1074.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.9239890261216, 966.0072903521143

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
561.574285474106, 987.7382350468738

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.7803419339538, 1031.8617946693341

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 989.9936076697743

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.8219277009699, 942.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
462.2038597539265, 417.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
459.0, 963.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.8857470672318, 359.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.6760444417674, 609.2535176342803

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0189691164192, 426.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.2471900261657, 613.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 359.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.5774527681926, 553.5610156344095

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0698344970132, 547.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 305.05458406215325

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.9751851892278, 289.6296198833601

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 191.26627567466969

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.0, 761.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.99897021833766, 359.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 765.9691115068547

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
975.0, 420.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0, 245.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 320.22882200355497

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0036968324808, 194.8662941790166

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0, 409.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.7309133324296, 753.0574204836305

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 759.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
838.0, 1187.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.0, 1187.2829174186304

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.0, 840.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 459.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.7988760535901, 490.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.231891432639, 573.4204891911131

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.2510617505231, 576.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.780571392251, 385.9618282009598

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.9781420356537, 349.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.7540371932674, 184.51101052709288

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.0, 1115.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.48016479864737, 470.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.0, 1133.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.0, 789.7975155950143

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.4319021055029, 417.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 550.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.8608380291771, 792.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 176.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.6683072977333, 476.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
944.0, 648.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 657.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
946.0, 614.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 721.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 316.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 751.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.9459451369956, 722.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
903.0, 791.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.0, 847.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
969.4204706649821, 805.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.0, 392.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.1877316447983, 408.0899458438937

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.4618485406781, 402.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.0, 379.99914566424286

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.3046315742924, 371.2622626448296

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.0, 325.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.0, 373.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 588.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.15135438863337, 662.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0097575263914, 462.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.5876987549066, 588.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 651.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.2188961382433, 443.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
539.0, 700.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.4394686431388, 711.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.8958662409676, 436.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 328.8437310710337

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.8823322690733, 330.0784191224139

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.0, 337.44326714253674

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.0, 320.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.0, 445.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.4625622833173, 506.6115561484353

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.5766215968036, 499.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.5281958488132, 429.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 506.48941102997907

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.9796695986458, 489.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 173.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.5631664759627, 277.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.5719500300767, 240.56485132523824

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.7639112242477, 197.27194393110386

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.8462884367482, 182.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
758.953557314557, 257.43481668836745

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
762.0, 186.6241387262427

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.0, 929.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 979.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.0, 241.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
826.0, 433.46417380497064

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.97814203565366, 241.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.3104235544095, 334.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.0, 438.9751851892278

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 255.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.0, 366.50674493453687

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.0, 409.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.55984526263495, 359.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.0, 118.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.6568542494924, 215.65685424949237

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.9247645396596, 175.09458073752205

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 120.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.743468945753, 369.8077087570679

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.0, 288.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.5777087639997, 362.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.0512809976892, 120.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 292.87183263447093

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
323.7201327147385, 295.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.21645747403153, 120.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.94116702040424, 261.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
317.0, 167.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
361.71839726831445, 120.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.3064601145268, 387.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.6978108927482, 394.5313887422553

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.5894663844042, 271.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.0, 648.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 674.7171557102205

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
71.0, 494.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
88.48713334483881, 553.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
97.548967469718, 345.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.0, 703.9775944791077

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
886.0, 432.9855816161193

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.3474977942104, 366.9924492668405

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.8959706991093, 377.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
655.0, 855.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.4, 295.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.7705935588815, 886.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.4564186264012, 375.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.0, 928.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.8533865548015, 899.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0, 956.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 865.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.9693977915938, 929.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.8954630462055, 891.2890551912172

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1040.0, 1037.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1153.7546727037216, 1046.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back