1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17223959.csml convertedTime:2009.07.01.10:59

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Translational mini-review series on Toll-like receptors: networks regulated byToll-like receptors mediate innate and adaptive immunity.
Authors Parker LC, Prince LR, Sabroe I.
Affiliation Academic Unit of Respiratory Medicine, School of Medicine and BiologicalSciences, University of Sheffield, UK.
Abstract The Toll-like receptor (TLR) family provide key components of mammalian immunityand are part of the earliest surveillance mechanisms responding to infection.Their activation triggers the innate immune response, and is crucial to thesuccessful induction of Th1/Th2-phenotyped adaptive immunity. Innate immunitywas long considered to be non-specific and somewhat simple compared to adaptiveimmunity, mediated via the engulfment and lysis of microbial pathogens byphagocytic cells such as macrophages and neutrophils, and involving no complexprotein-protein interactions. The emergence of the TLR field has contributed toa revision of our understanding, and innate immunity is now viewed as a highlycomplex process, in line with adaptive immunity. This review will give a briefoverview of our current knowledge of TLR biology, and will focus on TLRs as keycomponents in complex networks that activate, integrate and select theappropriate innate and adaptive immune responses in the face of immunologicaldanger.
PMID 17223959
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010389:IL-1beta G010961:TLR1 G010962:TLR2 G012252:CXCL10 MO000000030:PI3K MO000000058:NF-kappaB MO000000065:RIP1 MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK MO000007694:IRF-3 MO000007697:IRF-4 MO000007700:IRF-5 MO000007702:IRF-7 MO000008272:ROS MO000016573:MyD88 MO000016608:IKK-i MO000016882:LPS MO000016963:TRAF3 MO000017426:fibrinogen MO000019331:TBK1 MO000019394:TLR4: TLR4 MO000019395:TLRs MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000022185:flagellin MO000022224:dsRNA MO000035989:EDA MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042128:TLR10 MO000044940:HMGB1 MO000067735:HSPB8 MO000068831:MAL e1: e10: e100:LPS: TLR4: TLR4: TRAM: TRIF: TRAF3: TBK1: IKK-i e101:dsRNA: TLR3: TRIF e102:dsRNA: TLR3: TRIF: TRAF3 e103:dsRNA: TLR3: TRIF: TRAF3: TBK1: IKK-i e104:IRF-3 {activated} e105:TRIF: TRAF6 e106:ssRNA: TLR7: MyD88: TRAF3 e107:CpG DNA: TLR9: MyD88: TRAF3 e108:CXCL8 e109:CXCL2 e11: e110:poly (i:C): TLR3 e111:CXCL3 e12:lipoprotein e13:TLR1: TLR2 e14:TLR6: TLR2 e15:lipoteichoic acid e16:LPS: TLR6: TLR2 e17:LPS: TLR6: TLR2 e18:lipoprotein: TLR1: TLR2 e19:lipoprotein: TLR6: TLR2 e2: e20:lipoteichoic acid: TLR1: TLR2 e21:lipoteichoic acid: TLR6: TLR2 e22:lipoarabinomannan e23:lipoarabinomannan: TLR1: TLR2 e24:lipoarabinomannan: TLR1: TLR2 e25:TLR1: TLR10 e26:TLR2: TLR10 e27:TLR4 e28:TLR1: TLR4 e29:TLR5: TLR4 e3: e30:LPS: TLR4: TLR4 e31:dsRNA: TLR3 e32:flagellin: TLR5 e33:ssRNA e34:ssRNA: TLR7 e35:ssRNA: TLR8 e36:CpG DNA e37:CpG DNA: TLR9 e38:mRNA e39:mRNA: TLR3 e4: e40:loxoribine e41:imidazoquinoline e42:loxoribine: TLR7 e43:loxoribine: TLR8 e44:imidazoquinoline: TLR8 e45:imidazoquinoline: TLR7 e46:ROS: TLR2 e47:defensin: TLR2 e48:defensin e49:surfactant protein A e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:hyaluronic acid oligosaccharides e64:HSPB8: TLR4 e65:fibrinogen: TLR4 e66:surfactant protein A: TLR4 e67:EDA: TLR4 e68:hyaluronic acid oligosaccharides: TLR4 e69:HMGB1: TLR4 e7: e70:TLR ligand e71:HMGB1: TLR2 e72:TLR ligand: TLR e73:TLR ligand: TLR: MyD88 e74:LPS: TLR4: TLR4: MyD88 e75:TLR ligand: TLR: MyD88: IRAK-4 e76:TLR ligand: TLR: MyD88: IRAK-4: IRAK e77:TLR ligand: TLR: MyD88: IRAK-4: IRAK {p} e78:LPS: TLR4: TLR4: MyD88: MAL e79:TLR2 ligand e8: e80:TLR2 ligand: TLR2 e81:TLR2 ligand: TLR2: MyD88 e82:TLR2 ligand: TLR2: MyD88: MAL e83:TRAF6 {activated} e84:TAK1: TAB1: TAB2: TAB3 e85:TAK1: TAB1: TAB2: TAB3 {activated} e86:NF-kappaB {activated} e87:MAPKs {activated} e88:PI3K {activated} e89:ssRNA: TLR7: MyD88 e9: e90:CpG DNA: TLR9: MyD88 e91:IRF-7 {activated} e92:poly(I:C) e93:IFN-alpha e94:IRF-7 {nucleus} e95:MyD88: TRAF6: IRF-5 e96:MyD88: IRF-4 e97:LPS: TLR4: TLR4: TRAM e98:LPS: TLR4: TLR4: TRAM: TRIF e99:LPS: TLR4: TLR4: TRAM: TRIF: TRAF3

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p9
Model Detail
683.0, 1299.0
26.0, 26.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p55 p67

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
801.0, 1321.0
30.0, 30.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p77

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
798.0, 1242.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p75

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
802.0, 1282.0
28.0, 28.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p76

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
718.0, 1394.0
28.0, 28.0

TLR1

--

G010961

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p81

--

true true true true

csml-variable:Double

m93847

10

false

infinite

0

unit false false false
TRANSFACG010961

--

Go back
733.0, 1445.0
30.0, 30.0

TLR2

--

G010962

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p82

--

true true true true

csml-variable:Double

m93848

10

false

infinite

0

unit false false false
TRANSFACG010962

--

Go back
688.0, 1344.0
32.0, 32.0

CXCL10

--

G012252

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p68

--

true true true true

csml-variable:Double

m95041

10

false

infinite

0

unit false false false
TRANSFACG012252

--

Go back
1173.0, 1077.0
29.0, 29.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
863.0, 1031.0
34.0, 34.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p69

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
927.0, 1135.0
26.0, 26.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1173.0, 1173.0
29.5, 29.5

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p71

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
960.0, 792.0
31.5, 31.5

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p56

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1167.0, 1007.0
26.0, 26.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
748.0, 940.0
31.0, 31.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65 p66

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
877.0, 669.0
30.0, 30.0

IRF-4

--

MO000007697

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m978

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007697

--

Go back
894.0, 562.0
28.0, 28.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
739.0, 995.0
34.0, 34.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p74

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
386.0, 378.0
28.0, 28.0

ROS

--

MO000008272

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m1063

10

false

infinite

0

unit false false false
TRANSPATHMO000008272

--

Go back
841.0, 489.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p37 p43 p50 p51 p56 p57

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
794.0, 846.0
28.0, 28.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61 p64

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
300.0, 68.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p8 p15

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
701.0, 773.0
30.0, 30.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60 p63 p72 p73

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1192.0, 304.0
24.0, 24.0

fibrinogen

--

MO000017426

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m2254

10

false

infinite

0

unit false false false
TRANSPATHMO000017426

--

Go back
768.0, 784.0
31.0, 31.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61 p64

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
937.0, 209.0
29.5, 29.5

TLR4: TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1240.0, 744.0
31.0, 31.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
273.0, 289.0
29.0, 29.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p11 p13

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
274.0, 326.0
27.0, 27.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p12 p26 p27 p34 p42

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
469.0, 741.0
21.0, 21.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p21 p80

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
814.0, 206.0
27.0, 27.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p17

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
273.0, 365.0
29.5, 29.5

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
698.0, 106.0
28.0, 28.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
183.0, 743.0
33.0, 33.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1187.0, 359.0
25.5, 25.5

EDA

--

MO000035989

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m14425

10

false

infinite

0

unit false false false
InterProIPR008160
TRANSPATHMO000035989

--

Go back
1157.0, 857.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
751.0, 539.0
26.0, 26.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p62 p70

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1066.0, 482.0
27.0, 27.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
371.0, 967.0
26.5, 26.5

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p23 p25

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
439.0, 1135.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
374.0, 886.0
27.5, 27.5

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p22 p24

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
601.0, 185.0
29.0, 29.0

TLR10

--

MO000042128

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m19942

10

false

infinite

0

unit false false false
TRANSPATHMO000042128

--

Go back
1186.0, 486.0
28.0, 28.0

HMGB1

--

MO000044940

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34

true true true true

csml-variable:Double

m22603

10

false

infinite

0

unit false false false
TRANSPATHMO000044940

--

Go back
1164.0, 268.0
24.0, 24.0

HSPB8

--

MO000067735

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m42587

10

false

infinite

0

unit false false false
TRANSPATHMO000067735

--

Go back
884.0, 320.0
32.0, 32.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p44

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
268.1809694179904, 193.6095507255251
1031.2417443444392, 1418.5659011991663

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
279.5079223614491, 246.9016756155521
973.5777895875963, 1297.479094828839

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1243.875, 689.5
32.25, 45.0

LPS: TLR4: TLR4: TRAM: TRIF: TRAF3: TBK1: IKK-i

--

e100

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

p66

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
547.875, 769.5
32.25, 45.0

dsRNA: TLR3: TRIF

--

e101

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

p63

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
585.875, 828.5
27.64144797210497, 38.56946228665811

dsRNA: TLR3: TRIF: TRAF3

--

e102

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p63

p64

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
596.875, 879.5
29.472242613323544, 41.12405946045146

dsRNA: TLR3: TRIF: TRAF3: TBK1: IKK-i

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
844.0, 940.0
31.0, 31.0

IRF-3 {activated}

--

e104

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65 p66

p67 p68

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
878.875, 814.5
25.542347219673335, 35.640484492567445

TRIF: TRAF6

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

p69 p71

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
595.875, 993.5
29.535373463020736, 41.212149018168475

ssRNA: TLR7: MyD88: TRAF3

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

p52

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
564.875, 1059.5
29.74054872453661, 41.498440080748765

CpG DNA: TLR9: MyD88: TRAF3

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p73

p74

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
796.5, 1366.0
38.096885813148795, 20.31833910034602

CXCL8

--

e108

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p78

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
801.5, 1406.0
37.214532871972324, 19.847750865051903

CXCL2

--

e109

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p79

--

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
378.424857299983, 742.0
246.5641249312574, 411.6367170462517

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
379.75, 757.0
24.5, 30.0

poly (i:C): TLR3

--

e110

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p80

p81 p82

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
802.0, 1443.0
35.29411764705882, 18.823529411764703

CXCL3

--

e111

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p83

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
101.0, 468.5
37.77017508553028, 23.291607969410343

lipoprotein

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6 p7

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
275.875, 247.5
24.240273444668745, 33.823637364654076

TLR1: TLR2

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p4 p5 p7 p9

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
273.875, 408.5
27.712470178014314, 38.66856303908975

TLR6: TLR2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3 p6 p8 p10

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
93.5, 619.25
45.0, 25.5

lipoteichoic acid

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3 p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
257.875, 204.5
27.846623233620846, 38.8557533492384

LPS: TLR6: TLR2

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
338.875, 197.5
25.960589098917232, 36.22407781244266

LPS: TLR6: TLR2

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
273.875, 460.5
28.051798495136723, 39.14204441181869

lipoprotein: TLR1: TLR2

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
273.875, 512.5
27.57042576619563, 38.47036153422646

lipoprotein: TLR6: TLR2

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
268.1809694179904, 193.6095507255251
1031.2417443444392, 1418.5659011991663

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
269.875, 560.5
28.170168838318954, 39.307212332538086

lipoteichoic acid: TLR1: TLR2

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
271.875, 614.5
27.16796659937603, 37.90879060378051

lipoteichoic acid: TLR6: TLR2

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
93.5, 711.25
45.0, 25.5

lipoarabinomannan

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p9 p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
270.875, 661.5
26.49720132134337, 36.97283905303726

lipoarabinomannan: TLR1: TLR2

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
268.875, 703.5
29.66952651862727, 41.399339328317126

lipoarabinomannan: TLR1: TLR2

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
651.875, 177.5
32.25, 45.0

TLR1: TLR10

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
691.875, 201.5
32.25, 45.0

TLR2: TLR10

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
892.0, 208.0
31.5, 31.5

TLR4

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p14 p28 p29 p30 p31 p32 p33

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
733.5, 192.0
28.416773719948612, 39.65131216737018

TLR1: TLR4

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
849.875, 184.5
27.783492383923658, 38.76766379152138

TLR5: TLR4

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
288.8058043048792, 213.1490259486543
989.9920745706622, 1379.4869507529088

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
979.875, 197.5
32.25, 45.0

LPS: TLR4: TLR4

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p37 p59

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
413.875, 720.5
27.846623233620846, 38.8557533492384

dsRNA: TLR3

--

e31

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p16

p62

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
769.625, 182.5
29.278745209131806, 35.851524745875686

flagellin: TLR5

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
197.5, 911.625
45.0, 24.75

ssRNA

--

e33

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p18 p19

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
381.875, 920.5
28.38323545604698, 39.604514589833

ssRNA: TLR7

--

e34

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p18

p50

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
371.875, 1003.5
23.940401908607083, 33.40521196549825

ssRNA: TLR8

--

e35

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p19

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
217.5, 1180.125
45.0, 15.75

CpG DNA

--

e36

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
485.875, 1119.5
29.140805652413288, 40.66158928243715

CpG DNA: TLR9

--

e37

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p20

p51

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
445.5, 612.0
45.0, 24.0

mRNA

--

e38

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
502.625, 735.5
27.498708548575237, 33.67188801866355

mRNA: TLR3

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
326.9617488456237, 247.34310758912972
913.6801854891736, 1311.0987874719567

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
133.5, 919.25
45.0, 25.5

loxoribine

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p22 p23

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
93.5, 955.25
45.0, 25.5

imidazoquinoline

--

e41

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p24 p25

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
373.875, 844.5
27.854514589833, 38.866764543953025

loxoribine: TLR7

--

e42

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p22

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
374.875, 1042.5
25.274041108460267, 35.26610387227014

loxoribine: TLR8

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p23

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
384.875, 1095.5
22.961873738300607, 32.03982382088457

imidazoquinoline: TLR8

--

e44

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p25

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
367.875, 811.5
24.26394751330519, 33.85667094879795

imidazoquinoline: TLR7

--

e45

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p24

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
385.875, 196.5
27.712470178014314, 38.66856303908975

ROS: TLR2

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
420.875, 183.5
29.606395668930077, 41.311249770600114

defensin: TLR2

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
420.5, 416.125
31.560000000000002, 23.669999999999998

defensin

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1090.5, 328.125
26.71865566512377, 16.476504326826323

surfactant protein A

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
378.424857299983, 742.0
246.5641249312574, 411.6367170462517

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
579.8087953152859, 1141.3217581642086
446.9616536535418, 384.014263528327

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
628.0839832331731, 1150.4223379409025
261.3518794175274, 372.18630879952843

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
585.6351110984791, 1146.4472052133547
435.30902208715554, 373.76336943003474

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
586.4674419246498, 1147.2357355286078
433.6443604348144, 372.18630879952843

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
579.8087953152859, 1141.3217581642086
446.9616536535418, 384.014263528327

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
579.8087953152859, 1141.3217581642086
446.9616536535418, 384.014263528327

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
586.4674419246498, 1147.2357355286078
433.6443604348144, 372.18630879952843

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
906.0824791741093, 1299.0278212148562
27.923708287646438, 23.948060875781223

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
832.8373664711087, 1409.42206535031
79.07142848619456, 67.81360711177855

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
579.8087953152859, 1141.3217581642086
446.9616536535418, 384.014263528327

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
378.424857299983, 742.0
246.5641249312574, 411.6367170462517

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
685.1551422013035, 1311.9745237402137
14.154618830044255, 6.456544995948064

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
684.682479412765, 1292.7195786928296
48.44793582520561, 82.61714793587224

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
705.006979319925, 1346.4543090576249
7.562604616617451, 7.164630715305991

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1043.5, 388.25
40.13036164844407, 22.74053826745164

hyaluronic acid oligosaccharides

--

e63

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1218.625, 200.5
25.988126978836856, 31.82219630061656

HSPB8: TLR4

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1243.75, 249.0
24.5, 30.0

fibrinogen: TLR4

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1247.75, 297.0
24.5, 30.0

surfactant protein A: TLR4

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1247.75, 337.0
24.5, 30.0

EDA: TLR4

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1247.75, 385.0
24.5, 30.0

hyaluronic acid oligosaccharides: TLR4

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1243.75, 433.0
24.5, 30.0

HMGB1: TLR4

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
280.89954161361595, 198.96809397686084
949.3410626039362, 1274.4025000388924

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1321.0, 742.25
30.0, 19.5

TLR ligand

--

e70

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1243.75, 477.0
24.5, 30.0

HMGB1: TLR2

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p34

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1241.75, 794.0
28.63981003166139, 35.06915514080986

TLR ligand: TLR

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p36 p75 p76 p77 p78 p79 p83

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1238.25, 841.0
27.5211047898697, 38.40154156726004

TLR ligand: TLR: MyD88

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

p38

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1024.25, 181.0
32.39796292897779, 45.20645990089924

LPS: TLR4: TLR4: MyD88

--

e74

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

p41

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1243.25, 903.0
24.680216553496052, 34.43751146999449

TLR ligand: TLR: MyD88: IRAK-4

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

p39

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1244.25, 951.0
24.20673518076711, 33.7768397871169

TLR ligand: TLR: MyD88: IRAK-4: IRAK

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

p40

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1241.25, 995.0
29.415030280785466, 41.04422829877041

TLR ligand: TLR: MyD88: IRAK-4: IRAK {p}

--

e77

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

p45

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1091.25, 171.0
41.828133602495875, 58.36483758487796

LPS: TLR4: TLR4: MyD88: MAL

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
453.0, 106.25
30.0, 19.5

TLR2 ligand

--

e79

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p42

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
284.2911608657827, 221.46006663759238
910.7141934860609, 1252.7693993212936

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
483.75, 193.0
24.5, 30.0

TLR2 ligand: TLR2

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
518.25, 181.0
27.79730225729492, 38.78693338227197

TLR2 ligand: TLR2: MyD88

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
556.25, 170.0
31.372086621398424, 43.7750045879978

TLR2 ligand: TLR2: MyD88: MAL

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1032.0, 920.0
31.5, 31.5

TRAF6 {activated}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

p46 p70

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
981.25, 972.0
28.81528720866214, 40.2073775004588

TAK1: TAB1: TAB2: TAB3

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1033.25, 1028.0
28.81528720866214, 40.2073775004588

TAK1: TAB1: TAB2: TAB3 {activated}

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p47 p48 p49

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
859.0, 1075.0
34.0, 34.0

NF-kappaB {activated}

--

e86

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47 p69

--

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1173.0, 1229.0
29.5, 29.5

MAPKs {activated}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p71

--

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1177.0, 1125.0
29.0, 29.0

PI3K {activated}

--

e88

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

--

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
606.25, 941.0
27.457973940172508, 38.313452009543035

ssRNA: TLR7: MyD88

--

e89

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p50

p72

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
293.3354788715609, 243.95203929832394
906.5562836347395, 1236.3396425648034

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
536.25, 1103.0
24.340888236373644, 33.96403009726555

CpG DNA: TLR9: MyD88

--

e90

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p51

p73

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
739.0, 1055.0
34.0, 34.0

IRF-7 {activated}

--

e91

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52 p74

p54

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
177.0, 795.5
30.0, 17.0

poly(I:C)

--

e92

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p80

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
634.0, 1294.0
28.0, 28.0

IFN-alpha

--

e93

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p53

--

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
671.0, 1183.0
34.0, 34.0

IRF-7 {nucleus}

--

e94

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

p53 p55

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
857.5, 591.0
29.995044962378415, 41.85355111029546

MyD88: TRAF6: IRF-5

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
909.625, 634.5
28.91130644892518, 35.40159973337777

MyD88: IRF-4

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p56

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1243.875, 529.5
32.25, 45.0

LPS: TLR4: TLR4: TRAM

--

e97

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p59

p58

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1243.875, 581.5
32.25, 45.0

LPS: TLR4: TLR4: TRAM: TRIF

--

e98

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p58

p60

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1243.875, 637.5
32.25, 45.0

LPS: TLR4: TLR4: TRAM: TRIF: TRAF3

--

e99

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

p61

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
336.0, 252.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019396 MO000019397

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3963*m3964*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
182.0, 714.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e22 e14

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1

m22*m14*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
603.0, 243.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019396 MO000042128

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c35 : 1
stoichiometry:c33 : 1

m3963*m19942*0.1

nodelay

--

true

0

false

PMID: 17223959, 15728506 TLR10 was the orphan member of the family, but recent work has demonstrated its ability to form homodimers and also heterodimers with TLR1 and TLR2, although specific ligands for these combinations have yet to be identified.

Go back
656.0, 256.0
24.0, 24.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000042128

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c36 : 1
stoichiometry:c34 : 1

m3964*m19942*0.1

nodelay

--

true

0

false

PMID: 17223959, 15728506 TLR10 was the orphan member of the family, but recent work has demonstrated its ability to form homodimers and also heterodimers with TLR1 and TLR2, although specific ligands for these combinations have yet to be identified.

Go back
735.0, 291.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000019396

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c41 : 1

m27*m3963*0.1

nodelay

--

true

0

false

PMID: 17223959, 11932926, 12794153 TLR4 acts essentially as a homodimer (although there is some evidence for heterodimerization with TLR1 [22] and TLR5 [23]), and it also recognizes an extensive range of agonists.

Go back
851.0, 263.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019399 e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c240 : 1
stoichiometry:c42 : 1

m3966*m27*0.1

nodelay

--

true

0

false

PMID: 17223959, 11932926, 12794153 TLR4 acts essentially as a homodimer (although there is some evidence for heterodimerization with TLR1 [22] and TLR5 [23]), and it also recognizes an extensive range of agonists.

Go back
983.0, 71.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17223959, 11932926, 12794153 TLR4 acts essentially as a homodimer (although there is some evidence for heterodimerization with TLR1 [22] and TLR5 [23]), and it also recognizes an extensive range of agonists. PMID: 17223959, 9851930, 9989976, 10201887 TLR4 is crucial for effective responses to the Gram-negative bacterial component LPS [5?7], but also recognizes viral proteins [25,26].

Go back
307.0, 747.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000022224 MO000019398

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17223959, 11607032, 14579267, 14976261 TLR3 recognizes double-stranded RNA [29], while TLR7 and/or 8 mediate responses to single-stranded RNA, also derived from viruses [30,31].

Go back
771.0, 107.0
25.0, 25.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022185 MO000019399

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 17223959, 11323673, 14625549 In contrast, only a single agonist group has been identified so far for TLR5 comprising the flagellins, an essential protein component of bacterial flagella found in both Gram-positive and Gram-negative bacteria [27,28].

Go back
208.0, 872.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c51 : 1

m19940*m33*0.1

nodelay

--

true

0

false

PMID: 17223959, 11607032, 14579267, 14976261 TLR3 recognizes double-stranded RNA [29], while TLR7 and/or 8 mediate responses to single-stranded RNA, also derived from viruses [30,31].

Go back
208.0, 952.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e33 MO000042007

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m33*m19823*0.1

nodelay

--

true

0

false

PMID: 17223959, 11607032, 14579267, 14976261 TLR3 recognizes double-stranded RNA [29], while TLR7 and/or 8 mediate responses to single-stranded RNA, also derived from viruses [30,31].

Go back
332.0, 416.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019422 MO000019397

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
307.0, 1107.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e36 MO000042012

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m36*m19828*0.1

nodelay

--

true

0

false

PMID: 17223959, 14563635, 12900525 TLR9 recognizes unmethylated CG dinucleotides (CpG motifs), mediating responses to bacterial DNA and some viruses [34,35].

Go back
504.0, 676.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m3965*m38*0.1

nodelay

--

true

0

false

PMID: 17223959, 14729660, 12411706, 11083876 There is increasing evidence that ¡Æendogenous¡Ç ligands may also activate TLRs; these include products derived from host cells, for example mRNA [43] (recognized by TLR3), and anti-microbial molecules such as defensins [44] and reactive oxygen species (TLR2) [45].

Go back
144.0, 852.0
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 MO000042126

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c65 : 1
stoichiometry:c67 : 1

m40*m19940*0.1

nodelay

--

true

0

false

PMID: 17223959, 14579267, 12464152 TLR7 and 8 also respond to potent immunomodulatory nucleoside or nucleoside-like drugs, such as loxoribine and the imidazoquinolines [30,32], and appear to be responsible for the potent actions of the imidazoquinolines in the treatment of skin tumours [33].

Go back
145.0, 969.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 MO000042007

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c68 : 1

m40*m19823*0.1

nodelay

--

true

0

false

PMID: 17223959, 14579267, 12464152 TLR7 and 8 also respond to potent immunomodulatory nucleoside or nucleoside-like drugs, such as loxoribine and the imidazoquinolines [30,32], and appear to be responsible for the potent actions of the imidazoquinolines in the treatment of skin tumours [33].

Go back
103.0, 815.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000042126

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m41*m19940*0.1

nodelay

--

true

0

false

PMID: 17223959, 14579267, 12464152 TLR7 and 8 also respond to potent immunomodulatory nucleoside or nucleoside-like drugs, such as loxoribine and the imidazoquinolines [30,32], and appear to be responsible for the potent actions of the imidazoquinolines in the treatment of skin tumours [33].

Go back
104.0, 1040.0
23.0, 23.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000042007

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m41*m19823*0.1

nodelay

--

true

0

false

PMID: 17223959, 14579267, 12464152 TLR7 and 8 also respond to potent immunomodulatory nucleoside or nucleoside-like drugs, such as loxoribine and the imidazoquinolines [30,32], and appear to be responsible for the potent actions of the imidazoquinolines in the treatment of skin tumours [33].

Go back
388.0, 320.0
23.0, 23.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000008272

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c79 : 1
stoichiometry:c77 : 1

m3964*m1063*0.1

nodelay

--

true

0

false

PMID: 17223959, 14729660, 12411706, 11083876 There is increasing evidence that ¡Æendogenous¡Ç ligands may also activate TLRs; these include products derived from host cells, for example mRNA [43] (recognized by TLR3), and anti-microbial molecules such as defensins [44] and reactive oxygen species (TLR2) [45].

Go back
423.0, 327.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e48

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c80 : 1
stoichiometry:c78 : 1

m3964*m48*0.1

nodelay

--

true

0

false

PMID: 17223959, 14729660, 12411706, 11083876 There is increasing evidence that ¡Æendogenous¡Ç ligands may also activate TLRs; these include products derived from host cells, for example mRNA [43] (recognized by TLR3), and anti-microbial molecules such as defensins [44] and reactive oxygen species (TLR2) [45].

Go back
1112.0, 256.0
23.0, 23.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000067735

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c87 : 1
stoichiometry:c93 : 1

m27*m42587*0.1

nodelay

--

true

0

false

PMID: 17223959, 16709864,11509636, 12055204 In addition, products derived from damaged or dying cells can act as agonists, and proposed members of this category of TLR4-activators include heat shock protein B8 [46], fibrinogen [47], surfactant protein A [48] and the tissue matrix breakdown products fibronectin extra domain A [49] and hyaluronic acid oligosaccharides [50].

Go back
1112.0, 288.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000017426

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c88 : 1
stoichiometry:c94 : 1

m27*m2254*0.1

nodelay

--

true

0

false

PMID: 17223959, 16709864,11509636, 12055204 In addition, products derived from damaged or dying cells can act as agonists, and proposed members of this category of TLR4-activators include heat shock protein B8 [46], fibrinogen [47], surfactant protein A [48] and the tissue matrix breakdown products fibronectin extra domain A [49] and hyaluronic acid oligosaccharides [50].

Go back
179.0, 619.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e14

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c10 : 1
stoichiometry:c24 : 1

m15*m14*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
1152.0, 324.0
23.0, 23.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 e49

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c89 : 1
stoichiometry:c95 : 1

m27*m49*0.1

nodelay

--

true

0

false

PMID: 17223959, 16709864,11509636, 12055204 In addition, products derived from damaged or dying cells can act as agonists, and proposed members of this category of TLR4-activators include heat shock protein B8 [46], fibrinogen [47], surfactant protein A [48] and the tissue matrix breakdown products fibronectin extra domain A [49] and hyaluronic acid oligosaccharides [50].

Go back
1121.0, 357.0
21.0, 21.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000035989

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c90 : 1
stoichiometry:c96 : 1

m27*m14425*0.1

nodelay

--

true

0

false

PMID: 17223959, 16709864,11509636, 12055204 In addition, products derived from damaged or dying cells can act as agonists, and proposed members of this category of TLR4-activators include heat shock protein B8 [46], fibrinogen [47], surfactant protein A [48] and the tissue matrix breakdown products fibronectin extra domain A [49] and hyaluronic acid oligosaccharides [50].

Go back
1128.0, 388.0
23.0, 23.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 e63

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c91 : 1
stoichiometry:c97 : 1

m27*m63*0.1

nodelay

--

true

0

false

PMID: 17223959, 16709864,11509636, 12055204 In addition, products derived from damaged or dying cells can act as agonists, and proposed members of this category of TLR4-activators include heat shock protein B8 [46], fibrinogen [47], surfactant protein A [48] and the tissue matrix breakdown products fibronectin extra domain A [49] and hyaluronic acid oligosaccharides [50].

Go back
1136.0, 436.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000044940

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c92 : 1
stoichiometry:c98 : 1

m27*m22603*0.1

nodelay

--

true

0

false

PMID: 17223959, 16709864,11509636, 12055204 In addition, products derived from damaged or dying cells can act as agonists, and proposed members of this category of TLR4-activators include heat shock protein B8 [46], fibrinogen [47], surfactant protein A [48] and the tissue matrix breakdown products fibronectin extra domain A [49] and hyaluronic acid oligosaccharides [50].

Go back
1323.0, 515.0
25.0, 25.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000044940 MO000019397

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m22603*m3964*0.1

nodelay

--

true

0

false

PMID: 17223959, 16709864,11509636, 12055204 In addition, products derived from damaged or dying cells can act as agonists, and proposed members of this category of TLR4-activators include heat shock protein B8 [46], fibrinogen [47], surfactant protein A [48] and the tissue matrix breakdown products fibronectin extra domain A [49] and hyaluronic acid oligosaccharides [50].

Go back
1323.0, 799.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019395 e70

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m3962*m70*0.1

nodelay

--

true

0

false

PMID: 17223959 MyD88 is utilized by all the TLRs, except TLR3, and requires the bridging adapter Mal/TIRAP for TLR2 and TLR4 signalling.

Go back
1164.0, 800.0
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e72 MO000016573

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m72*m1572*0.1

nodelay

--

true

0

false

PMID: 17223959 MyD88 is utilized by all the TLRs, except TLR3, and requires the bridging adapter Mal/TIRAP for TLR2 and TLR4 signalling.

Go back
1027.0, 447.0
26.0, 26.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e30

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m1572*m30*0.1

nodelay

--

true

0

false

PMID: 17223959 MyD88 is utilized by all the TLRs, except TLR3, and requires the bridging adapter Mal/TIRAP for TLR2 and TLR4 signalling.

Go back
1315.0, 907.0
26.0, 26.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000039077 e73

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c161 : 1
stoichiometry:c113 : 1

m17258*m73*0.1

nodelay

--

true

0

false

PMID: 17223959 Upon activation MyD88 recruits IRAK-4, allowing association and phosphorylation of IRAK-1, which in turn recruits TRAF6.

Go back
1316.0, 956.0
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e75 MO000000213

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m75*m184*0.1

nodelay

--

true

0

false

PMID: 17223959 Upon activation MyD88 recruits IRAK-4, allowing association and phosphorylation of IRAK-1, which in turn recruits TRAF6.

Go back
320.0, 136.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e13

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c19 : 1
stoichiometry:c18 : 1

m155666*m13*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
1311.0, 1003.0
25.0, 25.0

p40

p40

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 17223959 Upon activation MyD88 recruits IRAK-4, allowing association and phosphorylation of IRAK-1, which in turn recruits TRAF6.

Go back
1066.0, 106.0
27.0, 27.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e74 MO000068831

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m74*m43675*0.1

nodelay

--

true

0

false

PMID: 17223959 MyD88 is utilized by all the TLRs, except TLR3, and requires the bridging adapter Mal/TIRAP for TLR2 and TLR4 signalling.

Go back
456.0, 244.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m3964*m79*0.1

nodelay

--

true

0

false

PMID: 17223959 MyD88 is utilized by all the TLRs, except TLR3, and requires the bridging adapter Mal/TIRAP for TLR2 and TLR4 signalling.

Go back
519.0, 331.0
25.0, 25.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e80 MO000016573

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c126 : 1
stoichiometry:c125 : 1

m80*m1572*0.1

nodelay

--

true

0

false

PMID: 17223959 MyD88 is utilized by all the TLRs, except TLR3, and requires the bridging adapter Mal/TIRAP for TLR2 and TLR4 signalling.

Go back
560.0, 324.0
23.0, 23.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e81 MO000068831

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c129 : 1
stoichiometry:c128 : 1

m81*m43675*0.1

nodelay

--

true

0

false

PMID: 17223959 MyD88 is utilized by all the TLRs, except TLR3, and requires the bridging adapter Mal/TIRAP for TLR2 and TLR4 signalling.

Go back
1035.0, 863.0
25.0, 25.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e77

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m183*m77*0.1

nodelay

--

true

0

false

PMID: 17223959, 10075645, 10601019, 14699155 TRAF6 activates the TAK-1/TAB1/2/3 complex, resulting in downstream cascades that lead ultimately to activation of nuclear factor (NF)-¦ÊB [56], and also initiation of distinct parallel signalling pathways leading to mitogen-activated protein (MAP) kinase [57?59] and phosphoinositide 3-kinase (PI3K) [60,61] activation.

Go back
1034.0, 978.0
27.0, 27.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e84 e83

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m84*m83*0.1

nodelay

--

true

0

false

PMID: 17223959, 10075645, 10601019, 14699155 TRAF6 activates the TAK-1/TAB1/2/3 complex, resulting in downstream cascades that lead ultimately to activation of nuclear factor (NF)-¦ÊB [56], and also initiation of distinct parallel signalling pathways leading to mitogen-activated protein (MAP) kinase [57?59] and phosphoinositide 3-kinase (PI3K) [60,61] activation.

Go back
947.0, 1035.0
25.0, 25.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e85 MO000000058

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m85*m86*0.1

nodelay

--

true

0

false

PMID: 17223959, 10075645, 10601019, 14699155 TRAF6 activates the TAK-1/TAB1/2/3 complex, resulting in downstream cascades that lead ultimately to activation of nuclear factor (NF)-¦ÊB [56], and also initiation of distinct parallel signalling pathways leading to mitogen-activated protein (MAP) kinase [57?59] and phosphoinositide 3-kinase (PI3K) [60,61] activation.

Go back
1119.0, 1127.0
25.0, 25.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e85 MO000000030

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m85*m90*0.1

nodelay

--

true

0

false

PMID: 17223959, 10075645, 10601019, 14699155 TRAF6 activates the TAK-1/TAB1/2/3 complex, resulting in downstream cascades that lead ultimately to activation of nuclear factor (NF)-¦ÊB [56], and also initiation of distinct parallel signalling pathways leading to mitogen-activated protein (MAP) kinase [57?59] and phosphoinositide 3-kinase (PI3K) [60,61] activation.

Go back
1118.0, 1174.0
27.0, 27.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e85

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c141 : 1

m88*m85*0.1

nodelay

--

true

0

false

PMID: 17223959, 10075645, 10601019, 14699155 TRAF6 activates the TAK-1/TAB1/2/3 complex, resulting in downstream cascades that lead ultimately to activation of nuclear factor (NF)-¦ÊB [56], and also initiation of distinct parallel signalling pathways leading to mitogen-activated protein (MAP) kinase [57?59] and phosphoinositide 3-kinase (PI3K) [60,61] activation.

Go back
183.0, 567.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e13

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c23 : 1

m15*m13*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
476.0, 912.0
23.0, 23.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e34 MO000016573

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c145 : 1
stoichiometry:c149 : 1

m34*m1572*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
500.0, 1048.0
23.0, 23.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000016573

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c147 : 1
stoichiometry:c150 : 1

m37*m1572*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
678.0, 998.0
27.0, 27.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e106

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c214 : 1
stoichiometry:c152 : 1

m980*m110*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
636.0, 1244.0
24.0, 24.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e94

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c158 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
673.0, 1109.0
27.0, 27.0

p54

p54

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e91

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
684.0, 1248.0
23.0, 23.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e94

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c155 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
967.0, 563.0
25.0, 25.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000007700 MO000000212 e96

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c169 : 1
stoichiometry:c164 : 1

m1572*m979*m183*0.1

nodelay

--

true

0

false

PMID: 17223959, 15665823 IRF-5 co-localizes and associates with MyD88 and TRAF-6 and is required for inflammatory cytokine, but not IFN-alpha/beta, production upon stimulation with TLR3, 4, 5, 7/8 and 9 ligands [66]. PMID: 17223959, 16236719 IRF-4 is a negative regulator of the signalling pathway, competing with IRF-5 for association with MyD88 [67].

Go back
1003.0, 615.0
26.0, 26.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007697 MO000016573

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m978*m1572*0.1

nodelay

--

true

0

false

PMID: 17223959, 16236719 IRF-4 is a negative regulator of the signalling pathway, competing with IRF-5 for association with MyD88 [67].

Go back
1163.0, 539.0
25.0, 25.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m18998*m100*0.1

nodelay

--

true

0

false

PMID: 17223959, 14556004 TRIF is recruited selectively by TLR3 and TLR4, although TLR4 requires a fourth adapter molecule, TRAM, to link it to TRIF [70].

Go back
1125.0, 485.0
21.0, 21.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 e30

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c170 : 1
stoichiometry:c172 : 1

m19005*m30*0.1

nodelay

--

true

0

false

PMID: 17223959, 14556004 TRIF is recruited selectively by TLR3 and TLR4, although TLR4 requires a fourth adapter molecule, TRAM, to link it to TRIF [70].

Go back
172.0, 520.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e14

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c14 : 1
stoichiometry:c22 : 1

m12*m14*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
1019.0, 647.0
25.0, 25.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m1872*m101*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
1035.0, 699.0
25.0, 25.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016608 MO000019331 e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m1599*m3902*m102*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
553.0, 621.0
22.0, 22.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000041125

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m31*m18998*0.1

nodelay

--

true

0

false

PMID: 17223959, 14556004 TRIF is recruited selectively by TLR3 and TLR4, although TLR4 requires a fourth adapter molecule, TRAM, to link it to TRIF [70].

Go back
603.0, 775.0
25.0, 25.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e101 MO000016963

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m104*m1872*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
691.0, 859.0
25.0, 25.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e102 MO000016608 MO000019331

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m105*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
756.0, 888.0
23.0, 23.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m977*m106*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
846.0, 886.0
27.0, 27.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e100

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c196 : 1
stoichiometry:c198 : 1

m977*m103*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
716.0, 1232.0
23.0, 23.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c199 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
732.0, 1272.0
23.0, 23.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c202 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 17223959, 16621716, 11698465 This pathway again utilizes TRAF3, which interacts with TBK-1 and IKK-epsilon to mediate activation of IRF-3 and finally induction of the IFN-beta promoter and several other target genes, for example CXCL10 [71,72].

Go back
927.0, 1079.0
25.0, 25.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 MO000000065 e105

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c206 : 1
stoichiometry:c208 : 1

m86*m108*m109*0.1

nodelay

--

true

0

false

PMID: 17223959, 15064760 TRIF also directly interacts with TRAF6, leading to NF-kappaB and MAP kinase activation, and with receptor-interacting protein (RIP) 1, a kinase thought to play a critical role in NF-kappaB activation [73].

Go back
179.0, 467.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e13

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c13 : 1
stoichiometry:c21 : 1

m12*m13*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
805.0, 689.0
23.0, 23.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e83

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c241 : 1
stoichiometry:c205 : 1

m18998*m83*0.1

nodelay

--

true

0

false

PMID: 17223959, 15064760 TRIF also directly interacts with TRAF6, leading to NF-kappaB and MAP kinase activation, and with receptor-interacting protein (RIP) 1, a kinase thought to play a critical role in NF-kappaB activation [73].

Go back
1113.0, 1229.0
30.0, 30.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e105 MO000000077

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m109*m88*0.1

nodelay

--

true

0

false

PMID: 17223959, 15064760 TRIF also directly interacts with TRAF6, leading to NF-kappaB and MAP kinase activation, and with receptor-interacting protein (RIP) 1, a kinase thought to play a critical role in NF-kappaB activation [73].

Go back
668.0, 948.0
23.0, 23.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e89

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c213 : 1

m1872*m92*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
556.0, 1008.0
23.0, 23.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e90

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m1872*m93*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
675.0, 1059.0
25.0, 25.0

p74

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e107

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c220 : 1
stoichiometry:c216 : 1

m980*m111*0.1

nodelay

--

true

0

false

PMID: 17223959, 16306937, 16306936, 15361868 In addition, TLR7 and TLR9 signalling via MyD88 can induce the type I interferons (IFNs) in a cascade also involving TRAF3 [62,63] and IFN regulatory factor (IRF)-7, which translocates to the nucleus and induces the IFN-alpha and IFN-beta promoters [64,65].

Go back
888.0, 1244.0
23.0, 23.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e72

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c221 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17223959, 10751418, 9673235 Cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 are often held to be principal exemplars of the panel of proinflammatory mediators produced in response to TLR stimuli; however, chemokine genes actually show the strongest gene induction [77,80].

Go back
888.0, 1284.0
23.0, 23.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e72

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c222 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17223959, 10751418, 9673235 Cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 are often held to be principal exemplars of the panel of proinflammatory mediators produced in response to TLR stimuli; however, chemokine genes actually show the strongest gene induction [77,80].

Go back
888.0, 1324.0
23.0, 23.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e72

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c223 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17223959, 10751418, 9673235 Cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 are often held to be principal exemplars of the panel of proinflammatory mediators produced in response to TLR stimuli; however, chemokine genes actually show the strongest gene induction [77,80].

Go back
888.0, 1364.0
23.0, 23.0

p78

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e72

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c224 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17223959, 10751418, 8558063, 9242519 CXCL8 and CXCL2/3 are the main CXC family members released in response to TLR activation [77], and are chemotactic primarily for neutrophils augmenting their degranulation, adhesion and microbicidal activity [82]; however, they can also influence T cell, basophil, eosinophil, NK cell and endothelial cell chemotaxis [81].

Go back
888.0, 1404.0
23.0, 23.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e72

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c225 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17223959, 10751418, 8558063, 9242519 CXCL8 and CXCL2/3 are the main CXC family members released in response to TLR activation [77], and are chemotactic primarily for neutrophils augmenting their degranulation, adhesion and microbicidal activity [82]; however, they can also influence T cell, basophil, eosinophil, NK cell and endothelial cell chemotaxis [81].

Go back
288.0, 136.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e14

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c20 : 1
stoichiometry:c17 : 1

m155666*m14*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
433.0, 793.0
21.0, 21.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e92 MO000019398

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m95*m3965*0.1

nodelay

--

true

0

false

PMID: 17223959, 16316467 the synthetic viral mimic poly(I:C), which activates TLR3, augments expression of TLR1 and TLR2, receptors that mediate bacterial responses [78].

Go back
653.0, 1397.0
21.0, 21.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e110

G010961

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c234 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 17223959, 16316467 the synthetic viral mimic poly(I:C), which activates TLR3, augments expression of TLR1 and TLR2, receptors that mediate bacterial responses [78].

Go back
680.0, 1448.0
23.0, 23.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e110

G010962

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c235 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 17223959, 16316467 the synthetic viral mimic poly(I:C), which activates TLR3, augments expression of TLR1 and TLR2, receptors that mediate bacterial responses [78].

Go back
892.0, 1440.0
23.0, 23.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e72

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c238 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17223959, 10751418, 8558063, 9242519 CXCL8 and CXCL2/3 are the main CXC family members released in response to TLR activation [77], and are chemotactic primarily for neutrophils augmenting their degranulation, adhesion and microbicidal activity [82]; however, they can also influence T cell, basophil, eosinophil, NK cell and endothelial cell chemotaxis [81].

Go back
181.0, 669.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e22 e13

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c29 : 1
stoichiometry:c27 : 1

m22*m13*0.1

nodelay

--

true

0

false

PMID: 17223959, 14978119, 11673543, 12935358 TLR2 acts as a heterodimer in concert with either TLR1 or TLR6, to mediate responses to moieties including lipoproteins and lipoteichoic acids (LTA) from Gram-positive bacteria [18] and rare lipopolysaccharide (LPS) species [19], and lipoarabinomannan from mycobacteria [20].

Go back
302.0, 276.48247494163365

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.40840262673018, 447.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.54044138228562, 40.099837503329894

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1275.282931819701, 500.31042355440945

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1271.0, 770.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1336.0, 762.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1278.0, 812.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1195.0, 812.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 518.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 819.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.0, 464.8462176857675

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 243.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 480.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.0, 234.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 140.21452822979705

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 877.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1276.0, 920.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1268.0, 928.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1193.0, 974.6400683942207

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1276.0, 968.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1268.0, 977.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1279.0, 1016.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.0, 139.1430767088629

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 492.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1085.0, 133.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.0, 265.3702656890036

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 126.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 229.94594513699568

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 223.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0, 228.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.1698434185678, 353.54871037888705

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 220.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 222.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 336.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.22718366753548, 281.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 823.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.0, 888.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1066.6337621523417, 888.471375594396

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1010.0, 992.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.0, 1005.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 952.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.0, 1048.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
897.0, 1048.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.1020362515915, 1055.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1062.0, 1063.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
200.65685424949237, 442.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1153.0, 1188.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1145.0, 1201.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1060.0, 1068.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1150.0592796928047, 1105.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 1140.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.26912118193826, 519.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.0, 927.3151918984429

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.2157030290837, 519.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
503.0, 1078.9195959492893

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 927.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
304.94028500029066, 100.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 1071.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.0, 1012.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.0, 1024.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.6208448322876, 803.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 960.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.0, 1271.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.4196987275691, 1084.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.0, 1136.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0, 1268.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.0, 1217.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.0, 100.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.6039472493969, 1217.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1266.0, 871.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 513.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0, 576.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.5799382318976, 580.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.0, 595.9984625732538

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
907.0, 637.2702633967525

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 516.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.731881015412, 631.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.0, 591.2408976431589

c169

c169

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
281.77320112697305, 159.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1007.0, 243.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 552.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1146.0, 501.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1093.0, 496.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1196.0, 552.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1188.0, 559.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 668.0110163756475

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.770195269737, 608.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.0, 660.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 724.190994282044

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.0, 159.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
799.0, 718.5394636186085

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.7709755200638, 664.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 712.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.0, 645.9699621023985

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.4190600600994, 557.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 643.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 789.6930369309188

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 788.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.1274319850065, 800.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 851.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.0, 166.47323821464306

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.947271486969, 862.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.9349894126537, 814.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.6462320697756, 876.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.0, 918.9810426273839

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.0, 900.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 907.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.2429679478531, 720.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 912.024550284402

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 913.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.4458366897195, 1255.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.0, 281.29482733884726

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
172.16208506051203, 147.99613361308894

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.6795832857008, 971.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.3418656930513, 971.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
715.7497264551948, 1295.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 565.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.0, 712.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 850.0

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
897.0, 1060.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 1092.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 1112.0

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
204.0, 480.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.0, 850.0

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1148.848442145943, 1202.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1143.0, 1244.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.2753247325671, 969.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.0, 1012.301672079202

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0301818392622, 1027.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.0, 1072.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.2843362028667, 803.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.0, 1038.8318433579009

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.0, 1031.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
195.0, 532.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 1073.598319585933

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
834.0, 1256.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
838.0, 1296.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
839.0, 1336.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 1376.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.0, 1416.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.9975603804354, 829.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
913.7339810838183, 829.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.4929923000594, 829.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.2638483682581, 829.0

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
208.0, 580.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.0629680827756, 829.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
207.0, 804.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.4867851613561, 762.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.79712132958497, 783.2189028942252

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.0, 1408.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
703.0, 1460.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.92650589328497, 773.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
55.70112801097494, 773.0

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
845.0, 1452.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.8549095704083, 829.0

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
204.0, 632.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.2494297193983, 240.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.6016693351397, 717.71150598877

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.0, 690.0209636589963

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 724.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.0, 680.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
201.0, 724.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.788600369559, 281.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 264.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
197.47848537441686, 447.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.0, 259.1571374662746

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 271.5050324183714

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 222.8784275570199

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 247.8623479330104

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 214.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0, 214.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 233.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.1554175279994, 232.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.0, 304.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 392.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
216.0, 760.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.0, 240.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
864.0, 231.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 84.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 103.64183217369941

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 96.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.99233879373105, 753.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.0, 744.4395279122544

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.0, 120.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.2582661881639, 139.30641508860998

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 353.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 132.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
231.0, 887.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.96193414021292, 885.7794900556852

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.0, 903.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.0, 936.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.9602975216799, 965.796029752168

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.0, 968.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.0, 1136.1628131933458

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.83608150167737, 1124.61115694427

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.0, 1121.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.0, 428.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 705.9459451369956

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.0, 636.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 699.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.0, 883.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
156.0, 945.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.90608840719608, 867.2221972416921

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.0, 980.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
167.0, 864.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
166.0, 983.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.0, 848.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 632.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.73455607561175, 833.0436835159137

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
128.0, 828.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.0, 981.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.72247608119582, 983.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
127.0, 1054.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.0, 333.550416732923

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 340.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 243.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 233.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 351.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 592.3402034518053

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 360.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 227.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 229.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 231.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 234.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 236.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 238.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.7766576685863, 271.8771242648312

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.828398279894, 303.64808384839876

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1117.0, 336.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.22968234058374, 281.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.9921104517296, 369.3552049089658

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.0, 400.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.6568542494924, 464.65685424949237

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1135.0, 225.50907520440964

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.0, 269.1228965159425

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1175.0, 316.91523910000535

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1142.0, 354.97383570699446

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1151.0, 400.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1159.0, 448.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1214.0, 503.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back