1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17223961.csml convertedTime:2009.07.01.11:00

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Translational mini-review series on Toll-like receptors: recent advances inunderstanding the role of Toll-like receptors in anti-viral immunity.
Authors Bowie AG.
Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Ireland.agbowie@tcd.ie
Abstract (TLRs) respond to pathogens to initiate the innate immune response and directadaptive immunity, and evidence to date suggests that they have a role in thedetection of viruses. Many viral macromolecules have been shown to activateanti-viral signalling pathways via TLRs, leading to the induction of cytokinesand interferons, while viruses also have means of not only evading detection byTLRs, but also of subverting these receptors for their own purposes. This reviewdiscusses the role of TLRs in the context of other known viral detectionsystems, and examines some of the often surprising results from studies usingmice deficient in TLRs and their adaptors, in an attempt to unravel theparticular contribution of TLRs to anti-viral immunity.
PMID 17223961
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010514:iNOS G010522:RANTES G010657:IL-12 p40 MO000000058:NF-kappaB{active} MO000000212:TRAF6 MO000007685:IRF-1 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000008179:PKR MO000016566:IRAK-2 MO000016573:MyD88 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000022224:dsRNA MO000022225:dsRNA:PKR MO000022528:TIRAP MO000041125:TRIF MO000041132:TRAM MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e11:eIF2alpha e12:eIF2alpha{p} e13: e14: e15: e16:TLR3:Poly(I:C) e17:Viral Glycoproteins e18:Viral Glycoproteins:TLR2 e19:CpG dinucleotides e2: e20:TLR9:CpG dinucleotides e21:ssRNA e22:TLR7:ssRNA e23:TLR8:ssRNA e24:mRNA e25:protein e26:Viral Glycoproteins:TLR2:Mal:MyD88 e27:NF-kappaB e28:TLR3:Poly(I:C):TRIF e29:IRF-3{active} e3: e30:IRF-5{active} e31:IRF-7{active} e32:TLR9:CpG dinucleotides:MyD88 e33:IRF-1{active} e34:TLR7:ssRNA:MyD88 e35:ssRNA e36:DDX58:ssRNA e37:IFIH1:ssRNA e38:DDX58:ssRNA:MAVS e39:IFIH1:ssRNA:MAVS e4: e40:Serine protease e41:protein remnants e42:HA e43:CD150 e44:Cd150 e45:A52 e46:A52:TRAF6:IRAK-2 e47:F protein e48:TLR4:F protein e49:TLR4:F protein:MyD88:TIRAP e5:Poly(I:C) e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:PKR:Poly(I:C) e60: e61: e62: e63:TLR4:F protein:TRIF:TRAM e64:A46 e65:TLR4:F protein:TRIF:TRAM:A46 e66:TLR4:F protein:MyD88:TIRAP:A46 e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p7 p8 p9
Model Detail
538.0, 850.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18 p19 p20 p29

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
439.0, 919.0
26.0, 26.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17 p49

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
414.0, 958.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
600.0, 984.0
24.0, 24.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
495.0, 767.0
26.0, 26.0

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
401.0, 829.0
22.0, 22.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21 p31

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
403.0, 567.0
26.0, 26.0

NF-kappaB{active}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p27 p32 p34 p41 p44 p56 p57

p17 p21 p22 p23

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
242.0, 450.0
20.0, 20.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
808.0, 684.0
24.0, 24.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
456.0, 424.0
23.0, 23.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p42 p45 p59

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
586.0, 546.0
20.0, 20.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p25 p35 p58

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
505.0, 645.0
22.0, 22.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p26 p36 p43 p46

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
338.0, 194.0
20.0, 20.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
303.0, 323.0
18.0, 18.0

IRAK-2

--

MO000016566

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m1569

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
265.0, 165.0
22.0, 22.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p24 p33 p54

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
175.0, 459.0
18.0, 18.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
186.0, 118.0
20.0, 20.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
699.0, 211.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
342.0, 50.0
20.0, 20.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
442.0, 198.0
20.0, 20.0

dsRNA:PKR

--

MO000022225

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p3

true true true true

csml-variable:Double

m6524

10

false

infinite

0

unit false false false
TRANSPATHMO000022225

--

Go back
235.0, 295.0
18.0, 18.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p54

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
539.0, 347.0
18.0, 18.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p47 p55

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
364.0, 336.0
16.0, 16.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
862.0, 470.0
20.0, 20.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
834.0, 270.0
20.0, 20.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
870.0, 382.0
20.0, 20.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
806.0, 846.0
20.0, 20.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
718.0, 1074.0
20.0, 20.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p40 p48

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
911.0, 975.0
18.0, 18.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
153.75, 85.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
169.30729458223453, 133.68602759414952
821.6703035400759, 1155.8590760699524

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
397.0, 259.5
21.6, 16.2

eIF2alpha

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3 p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
445.0, 387.5
21.6, 16.2

eIF2alpha{p}

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

p3 p4

p10

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
655.0, 197.0
257.4482392429785, 429.8076536514135

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
655.0, 197.0
257.4482392429785, 429.8076536514135

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
655.0, 197.0
257.4482392429785, 429.8076536514135

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
660.5, 258.0
22.238982679237008, 43.04319228239421

TLR3:Poly(I:C)

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p13

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
102.0, 103.0
11.540692235734328, 26.63236669784845

Viral Glycoproteins

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
178.5, 214.0
18.249287436965577, 35.32120149090112

Viral Glycoproteins:TLR2

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1062.0, 253.5
60.0, 13.0

CpG dinucleotides

--

e19

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
153.75, 85.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
858.5, 317.0
19.234816926112696, 37.22867792150845

TLR9:CpG dinucleotides

--

e20

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p7

p24

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1070.0, 394.5
60.0, 19.0

ssRNA

--

e21

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p8 p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
858.5, 422.0
18.636702477526857, 36.07103705327779

TLR7:ssRNA

--

e22

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

p33

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
839.5, 519.0
17.59000219250164, 34.045165533874155

TLR8:ssRNA

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
364.0, 769.0
39.653979238754324, 21.148788927335644

mRNA

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p10

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
319.0, 720.5
25.622861742805394, 15.800764741396659

protein

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
172.0, 276.0
24.08823529411765, 40.14705882352941

Viral Glycoproteins:TLR2:Mal:MyD88

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12 p49 p50

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
359.0, 499.0
26.0, 26.0

NF-kappaB

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p27 p32 p34 p41 p44 p56 p57

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
664.5, 324.0
23.547806937052673, 32.8574050284456

TLR3:Poly(I:C):TRIF

--

e28

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p13

p14 p15 p16 p32

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
516.0, 476.0
23.0, 23.0

IRF-3{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p42 p45 p59

p18

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
170.87518862352903, 103.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
706.0, 670.0
20.0, 20.0

IRF-5{active}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p25 p35 p58

p20

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
581.0, 653.0
22.0, 22.0

IRF-7{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p26 p36 p43 p46

p19

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
757.5, 533.0
21.11726922371077, 29.465957056340606

TLR9:CpG dinucleotides:MyD88

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25 p26 p27 p28

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
792.0, 756.0
24.0, 24.0

IRF-1{active}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p29 p30 p31

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
682.5, 479.0
18.552578454762344, 25.887318774086992

TLR7:ssRNA:MyD88

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34 p35 p36

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
862.0, 830.5
60.0, 19.0

ssRNA

--

e35

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p37 p38

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
781.5, 1007.0
21.54824195967339, 26.385602399600067

DDX58:ssRNA

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p39

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
889.5, 1035.0
21.54824195967339, 26.385602399600067

IFIH1:ssRNA

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p40

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
681.5, 1166.0
20.16241512204074, 28.133602495870804

DDX58:ssRNA:MAVS

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p41 p42 p43

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
889.5, 1106.0
20.16241512204074, 28.133602495870804

IFIH1:ssRNA:MAVS

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p44 p45 p46

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
202.55678757705792, 133.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
921.5, 697.0
13.8945461863554, 22.531696518414158

Serine protease

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p47 p48

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
849.0, 722.0
21.711659965537052, 20.987937966685816

protein remnants

--

e41

cso30:c:EntityBiological

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p47 p48

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
317.0, 783.5
22.88, 17.160000000000004

HA

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49 p50

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
367.0, 1009.0
42.35294117647059, 22.588235294117645

CD150

--

e43

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p50

p51

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
168.5, 970.0
23.532513181019333, 36.20386643233743

Cd150

--

e44

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p51

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
328.0, 364.5
24.379150734554226, 15.033809619641776

A52

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
314.5, 430.0
19.452193062947334, 27.14259497155442

A52:TRAF6:IRAK-2

--

e46

cso30:c:Complex

cso30:i:CC_Extracellular

--

p52

p12 p27 p32

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
96.0, 398.5
23.999999999999996, 18.0

F protein

--

e47

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p53

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
178.5, 518.0
18.684279763209823, 36.16312212234159

TLR4:F protein

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54 p55

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
175.0, 585.0
18.264705882352942, 30.44117647058823

TLR4:F protein:MyD88:TIRAP

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p57 p58 p61

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
415.0, 34.0
49.478553406223725, 28.037846930193446

Poly(I:C)

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2 p5

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
311.0, 689.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
361.29367619468036, 699.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
317.06992643728904, 694.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
317.93705878547314, 695.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
311.0, 689.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
311.0, 689.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
317.93705878547314, 695.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
650.9158804881849, 862.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
574.6082338479803, 983.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
311.0, 689.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
526.5, 188.0
19.253791034827533, 23.576070654890856

PKR:Poly(I:C)

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
420.7511016961721, 876.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
420.25867587120234, 855.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
441.43298634490145, 914.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
174.0, 676.0
19.058823529411768, 31.764705882352942

TLR4:F protein:TRIF:TRAM

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55

p56 p59 p60

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
241.0, 864.0
14.228250701590275, 32.83442469597755

A46

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p60 p61

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
174.0, 740.0
19.058823529411768, 31.764705882352942

TLR4:F protein:TRIF:TRAM:A46

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
175.0, 637.0
18.264705882352942, 30.44117647058823

TLR4:F protein:MyD88:TIRAP:A46

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
166.0, 89.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
169.0, 110.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
177.0, 131.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
371.0, 111.0
17.0, 17.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000008179

MO000022225

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m1055*0.1

nodelay

--

true

0

false

PMID: 17223961 The first viral PRR to be proposed was PKR, an intracellular detector of dsRNA and polyinosinic?polycytdylic acid (poly(I:C) (a synthetic dsRNA widely used to mimic viral infection).

Go back
371.0, 711.0
17.0, 17.0

p10

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e24 e12

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 17223961 A key function of PKR is to inhibit translation of host cell mRNA under conditions of viral invasion by phosphorylating the translation initiation factor eIF2alpha

Go back
234.0, 222.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000016573 MO000022528

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m18*m1572*m6810*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961 TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2.

Go back
434.0, 486.0
19.0, 19.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e27 e46

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c182 : 1
stoichiometry:c37 : 1

m26*m28*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961 TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2. PMID: 17223961,12566418,15767367 A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF¦ÊB and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52

Go back
573.0, 269.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000041125

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m16*m18998*0.1

nodelay

--

true

0

false

Go back
546.0, 426.0
19.0, 19.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000007694

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m29*m977*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961,16932750 Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB

Go back
630.0, 434.0
19.0, 19.0

p14

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000007700

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m29*m979*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961,16932750 Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB

Go back
546.0, 502.0
19.0, 19.0

p14

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000007702

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m29*m980*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961,16932750 Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB

Go back
497.0, 853.0
21.0, 21.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000058

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
530.0, 738.0
19.0, 19.0

p17

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e29

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
598.0, 754.0
19.0, 19.0

p17

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e31

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
439.0, 107.0
17.0, 17.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000008179

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m1055*0.1

nodelay

--

true

0

false

PMID: 17223961 The first viral PRR to be proposed was PKR, an intracellular detector of dsRNA and polyinosinic?polycytdylic acid (poly(I:C) (a synthetic dsRNA widely used to mimic viral infection).

Go back
602.0, 802.0
19.0, 19.0

p17

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e30

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
406.0, 782.0
19.0, 19.0

p17

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000058

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
470.0, 950.0
19.0, 19.0

p17

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000058

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
482.0, 722.0
19.0, 19.0

p17

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000058

G010522

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
785.0, 625.0
21.0, 21.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e20

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c64 : 1
stoichiometry:c66 : 1

m1572*m20*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3 PMID: 17223961,15665823,16006187 It was shown originally to be essential for signalling to TLR-induced NFKappaB activation, but was also shown subsequently to be required for TLR-induced IRF5 activation, and for TLR7- and TLR9-induced IRF7 activation

Go back
619.0, 603.0
17.0, 17.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000007700

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m33*m979*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
547.0, 583.0
17.0, 17.0

p25

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000007702

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m33*m980*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
479.0, 519.0
17.0, 17.0

p25

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e27 e46

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c183 : 1
stoichiometry:c75 : 1

m33*m28*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3 PMID: 17223961,12566418,15767367 A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF¦ÊB and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52

Go back
747.0, 663.0
17.0, 17.0

p25

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000007685

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m33*m970*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
614.0, 834.0
19.0, 19.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e33

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17223961,17018642 Most recently it has been shown that in myeloid DCs, TLR9-induced IFN-¦Â, IL-12 and inducible macrophage type nitric oxide synthase (iNOS) is dependent on MyD88-mediated IRF1 activation

Go back
466.0, 302.0
19.0, 19.0

p3

p3

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e11 MO000022225

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m11*m6524*0.1

nodelay

--

true

0

false

PMID: 17223961 A key function of PKR is to inhibit translation of host cell mRNA under conditions of viral invasion by phosphorylating the translation initiation factor eIF2alpha

Go back
678.0, 906.0
19.0, 19.0

p29

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e33

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17223961,17018642 Most recently it has been shown that in myeloid DCs, TLR9-induced IFN-¦Â, IL-12 and inducible macrophage type nitric oxide synthase (iNOS) is dependent on MyD88-mediated IRF1 activation

Go back
506.0, 910.0
19.0, 19.0

p29

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e33

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17223961,17018642 Most recently it has been shown that in myeloid DCs, TLR9-induced IFN-¦Â, IL-12 and inducible macrophage type nitric oxide synthase (iNOS) is dependent on MyD88-mediated IRF1 activation

Go back
526.0, 386.0
19.0, 19.0

p14

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e27 e46

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c148 : 1
stoichiometry:c87 : 1

m29*m28*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961,16932750 Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB PMID: 17223961,12566418,15767367 A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF¦ÊB and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52

Go back
765.0, 429.0
21.0, 21.0

p24

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016573

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m22*m1572*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3 PMID: 17223961,15665823,16006187 It was shown originally to be essential for signalling to TLR-induced NFKappaB activation, but was also shown subsequently to be required for TLR-induced IRF5 activation, and for TLR7- and TLR9-induced IRF7 activation

Go back
394.0, 426.0
19.0, 19.0

p25

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 e27

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m35*m28*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
622.0, 678.0
19.0, 19.0

p25

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e34

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c94 : 1
stoichiometry:c96 : 1

m979*m35*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
466.0, 550.0
19.0, 19.0

p25

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000007702

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m35*m980*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
831.0, 943.0
17.0, 17.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m41844*m36*0.1

nodelay

--

true

0

false

PMID: 17223961,17038589,17038590 These helicases were thought initially to detect viral dsRNA, although recently RIG-I has been shown to recognize uncapped 5¡ì-triphosphate viral ssRNA

Go back
883.0, 911.0
17.0, 17.0

p37

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000103999

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m36*m76904*0.1

nodelay

--

true

0

false

PMID: 17223961,17038589,17038590 These helicases were thought initially to detect viral dsRNA, although recently RIG-I has been shown to recognize uncapped 5¡ì-triphosphate viral ssRNA

Go back
758.0, 1170.0
19.0, 19.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000094908

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m37*m68199*0.1

nodelay

--

true

0

false

PMID: 17223961,16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
526.0, 258.0
19.0, 19.0

p3

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e6 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m6*m11*0.1

nodelay

--

true

0

false

PMID: 17223961 A key function of PKR is to inhibit translation of host cell mRNA under conditions of viral invasion by phosphorylating the translation initiation factor eIF2alpha

Go back
806.0, 1050.0
19.0, 19.0

p39

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000094908

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m38*m68199*0.1

nodelay

--

true

0

false

PMID: 17223961,16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
334.0, 1190.0
19.0, 19.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e27

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m39*m28*0.1

nodelay

--

true

0

false

PMID: 17223961, 16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
374.0, 1158.0
19.0, 19.0

p41

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 MO000007694

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m39*m977*0.1

nodelay

--

true

0

false

PMID: 17223961, 16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
442.0, 1126.0
19.0, 19.0

p41

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 MO000007702

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m39*m980*0.1

nodelay

--

true

0

false

PMID: 17223961, 16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
546.0, 1134.0
19.0, 19.0

p41

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 e27

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m40*m28*0.1

nodelay

--

true

0

false

PMID: 17223961, 16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
662.0, 1106.0
19.0, 19.0

p41

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 MO000007694

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m40*m977*0.1

nodelay

--

true

0

false

PMID: 17223961, 16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
838.0, 994.0
19.0, 19.0

p41

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 MO000007702

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m40*m980*0.1

nodelay

--

true

0

false

PMID: 17223961, 16127453,16125763,16153868,16177806 RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.

Go back
833.0, 629.0
19.0, 19.0

p47

p47

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e40 MO000041125

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m41*m18998*0.1

nodelay

--

true

0

false

PMID: 17223961,15710891 This virus has a serine protease which can cleave TRIF and thus prevent TLR3 signalling to NFKappaB and IRF3

Go back
870.0, 782.0
19.0, 19.0

p47

p48

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e40 MO000094908

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m41*m68199*0.1

nodelay

--

true

0

false

PMID: 17223961,15710891 This virus has a serine protease which can cleave TRIF and thus prevent TLR3 signalling to NFKappaB and IRF3

Go back
372.0, 872.0
23.0, 23.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26 e42

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m26*m43*0.1

nodelay

--

true

0

false

PMID: 17223961,12163593 For example, the haemagglutinin (HA) protein of wild-type, but not vaccine, strains of measles virus activates murine and human cells via TLR2, leading to induction of proinflammatory cytokines such as IL-6 in human monocytic cells, and up-regulation of surface expression of CD150, the receptor for measles virus

Go back
585.0, 157.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000019398

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m5*m3965*0.1

nodelay

--

true

0

false

PMID: 17223961,15961631,16043704 Although there is still no direct evidence of viral dsRNA binding to TLR3, both Choe et al. and Bell et al. showed that synthetic dsRNA [including poly(I:C)] could indeed bind to the ectodomain.

Go back
341.0, 953.0
21.0, 21.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e42 e26

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m43*m26*0.1

nodelay

--

true

0

false

PMID: 17223961,12163593 For example, the haemagglutinin (HA) protein of wild-type, but not vaccine, strains of measles virus activates murine and human cells via TLR2, leading to induction of proinflammatory cytokines such as IL-6 in human monocytic cells, and up-regulation of surface expression of CD150, the receptor for measles virus

Go back
246.0, 1026.0
19.0, 19.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 17223961,12163593 For example, the haemagglutinin (HA) protein of wild-type, but not vaccine, strains of measles virus activates murine and human cells via TLR2, leading to induction of proinflammatory cytokines such as IL-6 in human monocytic cells, and up-regulation of surface expression of CD150, the receptor for measles virus

Go back
227.0, 363.0
17.0, 17.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016566 MO000000212 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m1569*m183*m46*0.1

nodelay

--

true

0

false

PMID: 17223961,12566418,15767367 A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF¦ÊB and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52

Go back
94.0, 462.0
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e47 MO000019394

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m48*m3961*0.1

nodelay

--

true

0

false

PMID: 17223961,11062499 The first indication that viral proteins could activate TLRs was the case of the fusion (F) protein of respiratory syncitial virus (RSV)and TLR4

Go back
274.0, 490.0
19.0, 19.0

p11

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000022528 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m1572*m6810*m49*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961 TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2.

Go back
250.0, 594.0
19.0, 19.0

p11

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 MO000041125 e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m19005*m18998*m49*0.1

nodelay

--

true

0

false

PMID: 17223961 The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3 PMID: 17223961 TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2.

Go back
302.0, 694.0
19.0, 19.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 e27

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m64*m28*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
310.0, 518.0
19.0, 19.0

p56

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 e27

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m63*m28*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
370.0, 634.0
19.0, 19.0

p56

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 MO000007700

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m63*m979*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
338.0, 594.0
19.0, 19.0

p56

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 MO000007694

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m64*m977*0.1

nodelay

--

true

0

false

PMID: 17223961 Table 3

Go back
114.0, 174.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000019397

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m17*m3964*0.1

nodelay

--

true

0

false

PMID: 17223961 Similarly, TLR2 has been shown to mediate cellular responses to viral glycoproteins.

Go back
271.0, 795.0
17.0, 17.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m64*m65*0.1

nodelay

--

true

0

false

PMID: 17223961, 12566418, 15767367 A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF¦ÊB and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52

Go back
247.0, 663.0
17.0, 17.0

p60

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 e49

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m65*m63*0.1

nodelay

--

true

0

false

PMID: 17223961, 12566418, 15767367 A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF¦ÊB and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52

Go back
970.0, 270.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19828*m19*0.1

nodelay

--

true

0

false

PMID: 17223961,11130078 TLR9 was shown originally to be activated by bacterial DNA sequences containing unmethylated CpG dinucleotides

Go back
958.0, 394.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19940*m21*0.1

nodelay

--

true

0

false

PMID: 17223961 TLR7 and TLR8, which are related more closely to TLR9 than to other TLRs in terms of sequence similarity, also act in endosomes where they have been shown to trigger gene induction in response to viral ssRNA.

Go back
954.0, 470.0
19.0, 19.0

p8

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e21

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19823*m21*0.1

nodelay

--

true

0

false

PMID: 17223961 TLR7 and TLR8, which are related more closely to TLR9 than to other TLRs in terms of sequence similarity, also act in endosomes where they have been shown to trigger gene induction in response to viral ssRNA.

Go back
357.0, 70.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 212.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
819.0, 866.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.4213478575002, 850.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.5970433718076, 960.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 850.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.2635204975204, 935.3040696849266

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 928.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.2121199501515, 1033.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.0, 1094.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.0, 1180.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.9243989341309, 1050.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 268.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 1065.0471404825303

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 1066.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.9880535311839, 1181.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.3245446372141, 525.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0, 600.9470964439134

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.9931124357964, 1168.3318939419707

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.9165686008044, 447.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.0, 506.8253613331332

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.8720966352092, 1139.4248138706262

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.07088471832594, 667.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.223472969005, 277.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
455.0, 682.6686673375549

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.9817337573485, 1121.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
376.0, 525.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.9369089405902, 600.7619832359946

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.9985352344646, 1116.1530820140567

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
471.0, 447.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.7857377678156, 506.7981498206047

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.2926937794119, 1020.2909647972695

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.0, 667.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.8096138059561, 681.3927783504167

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.0, 62.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.2034868806554, 651.0514107456765

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.0, 365.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 648.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.9691115068547, 719.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
733.0, 808.0973087114396

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
866.5298221281347, 750.5894663844041

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
191.0, 316.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
395.0, 892.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
333.0, 801.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
329.0, 801.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.2613881364466, 176.35741602007747

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0, 316.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
358.0, 974.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.945204834583, 1023.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
198.769862720718, 1000.2625061574892

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.08194780350578, 337.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.4607375507422, 387.8655098886119

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 372.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 378.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.0, 398.8935046253176

c148

c148

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
105.53215208419019, 417.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 178.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
120.990651168656, 468.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
113.0, 479.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 187.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.0, 313.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 506.819639919603

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
198.65685424949237, 509.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
267.1842634229863, 352.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.06770299741044, 364.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 545.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
198.24282653774407, 613.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
111.0, 130.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.0, 693.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.39391429035845, 525.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 599.1208608422172

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
193.0, 536.745877408417

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.6626102817692, 516.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.0, 533.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
193.0, 602.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.4121425450471, 560.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
389.0, 645.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
193.0, 612.7899007857226

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
139.32765345276295, 136.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.64990554975276, 447.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 500.31963755426915

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
193.0, 703.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.0, 819.3677380085485

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
200.15541752799933, 764.5777087639997

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.0, 687.9942170515637

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.0, 609.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
200.70814327703954, 657.1411509102887

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
133.0, 191.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.0, 448.0

c182

c182

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
334.0, 449.0

c183

c183

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
854.0, 280.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.0, 135.48127556231887

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.876086539512, 265.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.1554175279994, 285.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.0, 393.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.0, 404.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.5318292445987, 408.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.0, 480.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.9962562338314, 414.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.1993955485456, 485.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.5838051064926, 735.9786697887325

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.90697358120497, 722.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 128.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.913328934415, 404.0

c30

c30

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
197.0, 232.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.96911150685466, 187.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 249.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.51724137931035, 241.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.0, 305.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 499.75230673845374

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.5664562694431, 505.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.0, 280.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 297.2299027111483

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.0, 62.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.0, 287.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.2469504755443, 349.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
479.0, 436.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.8466608896548, 445.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.6471701423768, 357.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 460.4605447861927

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.0, 453.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.5816675103376, 356.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.0, 528.7152317131197

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 521.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.0, 129.27329302959447

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 593.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
468.08084319674055, 874.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0, 499.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.0, 757.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 675.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.9005376398869, 773.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.9425724154552, 690.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0621504188273, 821.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.0, 593.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.5699763999033, 801.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.0, 124.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.0, 593.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
449.76114000116263, 962.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.0, 593.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.0, 741.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.8658978935465, 354.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 186.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
775.4206330594147, 569.6249941371564

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.2931332664081, 553.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
602.0, 566.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 618.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.0, 275.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.8351867815206, 550.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.0, 606.7924528301887

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 600.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.9811865548803, 529.5483257938467

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 514.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.49227473161193, 535.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.7882251601028, 562.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.4623850752448, 677.8831942336172

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0, 680.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.3722099360788, 773.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
459.85819745644653, 321.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.7218109753595, 847.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.9425724154552, 780.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
628.5074104802507, 925.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0741663966368, 774.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
429.3353125974796, 852.8850603161288

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.4490260061301, 345.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 407.627990121045

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.38022138493056, 405.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.0, 440.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 182.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 218.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
707.831526369483, 447.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.8556362301803, 439.5129373480347

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
377.0, 452.36019183191667

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
405.0, 445.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.3433641653008, 505.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
599.0, 566.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 681.7353353937364

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.6344663941373, 495.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
483.0214708392368, 576.4074768961935

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.0, 568.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back