1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17273997.csml convertedTime:2009.07.01.11:00

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TLR pathways and IFN-regulatory factors: to each its own.
Authors Colonna M.
Affiliation Washington University School of Medicine, St Louis, MO 63110, USA.mcolonna@pathology.wustl.edu
Abstract TLR trigger the induction of type I IFN (IFN-alpha/beta), providing a crucialmechanism of anti-viral defense. Until recently, TLR were thought to induce typeI IFN responses by activating two transcription factors which belong to theIFN-regulatory factor (IRF) family, IRF-3 and IRF-7. TLR-3 and TLR-4 induceIFN-beta by activating IRF-3; TLR-9 induces IFN-alpha and IFN-beta throughIRF-7, at least when engaged by type A CpG oligonucleotides (CpG-A) inplasmacytoid DC (pDC). In this issue of the European Journal of Immunology, itis demonstrated that TLR-9 induces IFN-beta when engaged by type B CpGoligonucleotides (CpG-B) in myeloid DC and macrophages. Remarkably, thisresponse is independent of IRF-3/7 and, in fact, requires another IRF familymember, IRF-1. IRF-1 is recruited by TLR-9 through the adaptor MyD88. Deficiencyof the TLR-9-->IRF-1-->IFN-beta pathway results in impaired anti-viral responsesnot only in vitro but also in vivo. These results demonstrate that TLR induceIFN-alpha or IFN-beta responses by activating distinct IRF, depending on the TLRligand and the cell type. These distinct TLR-IRF pathways may allow the immunesystem to tailor its responses to viral pathogens.
PMID 17273997
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010384:IRF-1 G010514:iNOS G010657:IL-12 p40 G010713:IRF-7 G012390:IL15 MO000000058:NF-kappaB MO000000145:Jak1 MO000000212:TRAF6 MO000000213:IRAK-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000007685:IRF-1 MO000007694:IRF-3 MO000007697:IRF-4 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016608:IKK-i MO000016656:STATs MO000016660:IFNbeta MO000016665:IFNgamma MO000016963:TRAF3 MO000017063:IL-15 MO000017265:IL-12 MO000019331:TBK1 MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000022224:dsRNA MO000039077:IRAK-4 MO000041125:TRIF MO000041456:IRF-3{p} MO000042012:TLR9 MO000103999:MDA-5 e1: e10: e11:TLR ligand: TLR: MyD88 e12: e13: e14: e15:TLR ligand: TLR: MyD88: IRAK-1: IRAK-4 e16:TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5: TRAF6 e17:TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5 e18:NF-kappaB {activated} e19:NF-kappaB {nucleus} e2: e20:NF-kappaB: NF-kappaB target genes e21:RIG-1 e22:dsRNA: TLR3 e23:TLR4 ligand e24:TLR4 ligand: TLR4 e25:dsRNA: TLR3: TRIF e26:TLR4 ligand: TLR4: TRIF e27:dsRNA: TLR3: TRIF: TRAF3 e28:TLR4 ligand: TLR4: TRIF: TRAF3 e29:TLR4 ligand: TLR4: TRIF: TRAF3: TBK1: IKKepsilon e3: e30:dsRNA: TLR3: TRIF: TRAF3: TBK1: IKKepsilon e31:IRF-3{p} e32:IRF-3: IRF-3 target genes e33:IP-10 e34:CpG-A oligonucleotides e35:CpG-A oligonucleotides e36:CpG-A oligonucleotides: TLR9 e37:CpG-B oligonucleotides: TLR9 e38:CpG-A oligonucleotides: TLR9: MyD88 e39:CpG-B oligonucleotides: TLR9: MyD88 e4: e40:CpG-B oligonucleotides: TLR9: MyD88: IRF-1 e41:CpG-A oligonucleotides: TLR9: MyD88: TRAF3 e42:CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7 e43:CpG-B oligonucleotides: TLR9: MyD88: IRF-1 {activated} e44:IRF-1 {activated} e45:IRF-1 {nucleus} e46:IRF-1: IRF-1 target genes e47:IL-12 p35 e48:CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4 e49:CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6 e5:TLR ligand e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR ligand: TLR e60: e61: e62: e63:CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7 {activated} e64:IRF-7 {activated} e65:IRF-7 {nucleus} e66:IRF-7: IRF target genes e67:IFN-alpha e68:MyD88: IRF-4 e69:dsRNA: MDA-5 e7: e70:dsRNA: RIG-1 e71:IPS-1 e72:dsRNA: RIG-1: IPS-1 e73:dsRNA: RIG-1: IPS-1: TBK1: IKKepsilon e74:Type I IFN receptor e75:IFNbeta: Type I IFN receptor e76:Jak1 {activated} e77:STATs {activated} e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p7 p8 p9
Model Detail
618.0, 1074.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27 p58

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
668.0, 1189.0
30.0, 30.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p10

p13

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
621.0, 1162.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p9

p12

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
515.0, 1191.0
26.0, 26.0

IRF-1

--

G010384

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p56

--

true true true true

csml-variable:Double

m93359

10

false

infinite

0

unit false false false
TRANSFACG010384

--

Go back
555.0, 1103.0
26.0, 26.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p41

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
722.0, 1199.0
26.0, 26.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p11

p14

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
591.0, 1239.0
25.0, 25.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p64

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
432.0, 1148.0
24.5, 24.5

IL15

--

G012390

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p57

p60

true true true true

csml-variable:Double

m95141

10

false

infinite

0

unit false false false
TRANSFACG012390

--

Go back
891.0, 539.0
26.0, 26.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p44

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
266.0, 1242.0
28.0, 28.0

Jak1

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
892.0, 488.0
24.0, 24.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p43

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
848.0, 328.0
24.5, 24.5

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p42

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
620.0, 1433.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
676.0, 1437.0
22.0, 22.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
281.0, 769.0
30.0, 30.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
665.0, 470.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p24 p55

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
794.0, 230.0
28.0, 28.0

IRF-4

--

MO000007697

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m978

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007697

--

Go back
891.0, 451.0
26.0, 26.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
570.0, 786.0
28.0, 28.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
860.0, 228.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p31 p32 p45

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
634.0, 294.0
27.5, 27.5

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22 p54

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
367.0, 1243.0
26.0, 26.0

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
110.0, 1286.0
28.0, 28.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
110.0, 1190.0
28.0, 28.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
587.0, 291.0
25.0, 25.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p34

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
111.0, 1147.0
26.0, 26.0

IL-15

--

MO000017063

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

p59

true true true true

csml-variable:Double

m1956

10

false

infinite

0

unit false false false
InterProIPR003443
TRANSPATHMO000017063

--

Go back
724.0, 1433.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
682.0, 282.0
28.0, 28.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22 p54

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
826.0, 178.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
966.0, 114.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
406.0, 314.0
24.0, 24.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
391.0, 63.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p51 p52

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
847.0, 383.0
26.0, 26.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p42

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
539.0, 199.0
26.0, 26.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p18

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
669.0, 582.0
28.0, 28.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23 p24 p55

p25

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
327.0, 527.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
257.0, 173.0
22.0, 22.0

MDA-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
174.69383560938692, 102.9033573139475
887.3155955670658, 1288.3822447633788

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
214.0, 167.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1022.875, 221.5
32.25, 45.0

TLR ligand: TLR: MyD88

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
328.30529270096525, 316.2130734075436
276.0725162611644, 460.9007263004189

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
328.30529270096525, 316.2130734075436
276.0725162611644, 460.9007263004189

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
328.30529270096525, 316.2130734075436
276.0725162611644, 460.9007263004189

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
1011.875, 373.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK-1: IRAK-4

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1011.875, 529.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5: TRAF6

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1011.875, 441.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p4

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
947.0, 595.0
26.0, 26.0

NF-kappaB {activated}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p44

p8

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
795.0, 991.0
26.0, 26.0

NF-kappaB {nucleus}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p7

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
174.69383560938692, 102.9033573139475
887.3155955670658, 1288.3822447633788

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
785.5, 1117.625
45.0, 12.75

NF-kappaB: NF-kappaB target genes

--

e20

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p9 p10 p11

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
257.375, 203.5
21.047891036906854, 32.38137082601055

RIG-1

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
492.625, 322.5
28.739835027495424, 35.191634727545406

dsRNA: TLR3

--

e22

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p15

p18

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
825.5, 70.375
28.339191564147622, 18.420474516695958

TLR4 ligand

--

e23

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p16

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
778.625, 179.5
27.27007998666889, 33.39193467755374

TLR4 ligand: TLR4

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p17

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
536.875, 363.5
29.472242613323544, 41.12405946045146

dsRNA: TLR3: TRIF

--

e25

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p18

p20

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
600.875, 123.5
29.606395668930077, 41.311249770600114

TLR4 ligand: TLR4: TRIF

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p17

p19

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
568.875, 427.5
30.01674619196183, 41.88383189576069

dsRNA: TLR3: TRIF: TRAF3

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p20

p22

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
661.875, 116.5
28.114929344833914, 39.23013396953569

TLR4 ligand: TLR4: TRIF: TRAF3

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p21

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
695.875, 101.5
32.25, 45.0

TLR4 ligand: TLR4: TRIF: TRAF3: TBK1: IKKepsilon

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p24

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
192.4401475207282, 120.64966922528882
851.8229717443832, 1252.889620940697

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
585.875, 512.5
27.578317122407782, 38.48137272894109

dsRNA: TLR3: TRIF: TRAF3: TBK1: IKKepsilon

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
670.0, 886.0
28.0, 28.0

IRF-3{p}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p26

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
717.5, 953.625
45.0, 12.75

IRF-3: IRF-3 target genes

--

e32

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p26

p27 p28

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
739.5, 1079.0
33.892733564013845, 18.07612456747405

IP-10

--

e33

cso30:c:mRNA

cso30:i:CC_NuclearChromosome

--

p28

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
82.5, 530.25
35.18502943650126, 19.938183347350716

CpG-A oligonucleotides

--

e34

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p29

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
77.5, 581.25
37.026913372582, 20.98191757779647

CpG-A oligonucleotides

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p30

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
318.625, 483.5
26.429053491084822, 32.362106315614064

CpG-A oligonucleotides: TLR9

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p31

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
323.625, 576.5
25.628853524412598, 31.382269621729716

CpG-B oligonucleotides: TLR9

--

e37

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p30

p32

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
311.875, 425.5
32.25, 45.0

CpG-A oligonucleotides: TLR9: MyD88

--

e38

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p31

p34 p42

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
311.875, 633.5
32.25, 45.0

CpG-B oligonucleotides: TLR9: MyD88

--

e39

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p32 p38

p33

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
225.27082455670978, 151.70571507013594
786.1616176724207, 1190.7775292510007

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
319.875, 693.5
32.25, 45.0

CpG-B oligonucleotides: TLR9: MyD88: IRF-1

--

e40

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p33

p37

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
539.875, 669.5
32.25, 45.0

CpG-A oligonucleotides: TLR9: MyD88: TRAF3

--

e41

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p34 p47

p35

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
507.875, 721.5
32.25, 45.0

CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7

--

e42

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p35

p46

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
397.875, 754.5
36.10887318774087, 50.38447421545238

CpG-B oligonucleotides: TLR9: MyD88: IRF-1 {activated}

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p37

p38

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
345.0, 913.0
30.0, 30.0

IRF-1 {activated}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p36

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
429.0, 985.0
30.0, 30.0

IRF-1 {nucleus}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p39

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
421.5, 1037.625
45.0, 12.75

IRF-1: IRF-1 target genes

--

e46

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p39

p40 p41 p57 p58

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
497.5, 1150.0
37.110726643598625, 19.792387543252595

IL-12 p35

--

e47

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
587.875, 557.5
32.25, 45.0

CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p43

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
571.875, 621.5
32.25, 45.0

CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6

--

e49

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p43

p44

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
949.0, 42.5
29.701230228470997, 19.30579964850615

TLR ligand

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
375.8724887638952, 854.2497079183618
483.2088545452466, 438.21734108665754

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
428.0626443758585, 864.6348218343074
282.54670451993945, 424.71988704908085

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
382.1713006480977, 860.0986046679784
470.61123077684204, 426.5195475874243

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
383.07113091726933, 860.99843493715
468.81157023849823, 424.71988704908085

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
375.8724887638952, 854.2497079183618
483.2088545452466, 438.21734108665754

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
375.8724887638952, 854.2497079183618
483.2088545452466, 438.21734108665754

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
383.07113091726933, 860.99843493715
468.81157023849823, 424.71988704908085

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
728.6059542792336, 1034.2157617527182
30.188234238967183, 27.328296258433465

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
649.4208905921168, 1160.1919994367677
85.48387557131925, 77.38540314877324

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
375.8724887638952, 854.2497079183618
483.2088545452466, 438.21734108665754

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1009.5, 98.0
28.94600899850025, 35.4440926512248

TLR ligand: TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
489.76209695112635, 1048.9898732775728
15.302514422617437, 7.367877314593583

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
489.25110267953966, 1027.0171195993435
52.37691283764046, 94.27844310775279

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
511.2238563577696, 1088.336432189752
8.175908345387771, 8.17590834538777

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
451.875, 737.5
32.25, 45.0

CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7 {activated}

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p47

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
458.0, 854.0
28.0, 28.0

IRF-7 {activated}

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

p48

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
478.0, 942.0
28.0, 28.0

IRF-7 {nucleus}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p49

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
557.5, 905.625
45.0, 12.75

IRF-7: IRF target genes

--

e66

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p49

p50

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
590.0, 866.0
28.0, 28.0

IFN-alpha

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p50

--

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
949.625, 282.5
29.27874520913181, 35.851524745875686

MyD88: IRF-4

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
369.625, 170.5
21.44821696383936, 26.263122812864523

dsRNA: MDA-5

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
217.0, 153.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
256.375, 241.5
23.25, 45.0

dsRNA: RIG-1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p53

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
260.25, 301.5
12.957436856875585, 29.901777362020574

IPS-1

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
251.875, 338.5
25.131996696641583, 35.067902367406866

dsRNA: RIG-1: IPS-1

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
375.875, 249.5
32.25, 45.0

dsRNA: RIG-1: IPS-1: TBK1: IKKepsilon

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p55

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
175.375, 1273.5
24.474956063268895, 37.653778558875224

Type I IFN receptor

--

e74

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p61

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
176.375, 1329.5
23.25, 45.0

IFNbeta: Type I IFN receptor

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p61

p62

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
314.0, 1290.0
28.0, 28.0

Jak1 {activated}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

p63

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
427.0, 1291.0
26.0, 26.0

STATs {activated}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

p64

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
220.0, 174.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
228.0, 195.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1011.0, 43.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000019395

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m3962*0.1

nodelay

--

true

0

false

PMID: 17273997 These results demonstrate that TLR induce IFN-alpha or IFN-beta responses by activating distinct IRF, depending on the TLR ligand and the cell type.

Go back
732.0, 1156.0
23.0, 23.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c23 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes. PMID: 17273997 Both NF-kappaB and IRF-5 induce transcription of pro-inflammatory cytokine genes (TNF-alpha, IL-6, IL-12p40).

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768.0, 1172.0
23.0, 23.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes. PMID: 17273997 Both NF-kappaB and IRF-5 induce transcription of pro-inflammatory cytokine genes (TNF-alpha, IL-6, IL-12p40).

Go back
623.0, 1296.0
23.0, 23.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c28 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.

Go back
674.0, 1295.0
25.0, 25.0

p13

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c29 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.

Go back
726.0, 1295.0
25.0, 25.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c30 : 1

m93589*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.

Go back
473.0, 273.0
22.0, 22.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
828.0, 124.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e23 MO000019394

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m24*m3961*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
542.0, 58.0
20.0, 20.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000041125

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m25*m18998*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
541.0, 293.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e22

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m18998*m23*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
608.0, 200.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m1872*m27*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
924.0, 232.0
24.0, 24.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m1572*m6*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.

Go back
590.0, 339.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e25

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c51 : 1

m1872*m26*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
664.0, 200.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016608 MO000019331 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m1599*m3902*m29*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
635.0, 419.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000016608 MO000019331

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m28*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
638.0, 522.0
27.0, 27.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e30 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m31*m977*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway. PMID: 17273997, 16932750 It has previously been shown that phosphorylation is a critical event in IRF activation.

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701.0, 522.0
27.0, 27.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e29

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c60 : 1
stoichiometry:c65 : 1

m977*m30*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway. PMID: 17273997, 16932750 It has previously been shown that phosphorylation is a critical event in IRF activation.

Go back
670.0, 827.0
25.0, 25.0

p25

p25

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041456

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17273997 The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction. PMID: 17273997 PMID: 17273997 In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
672.0, 948.0
23.0, 23.0

p26

p26

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 17273997 The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction. PMID: 17273997 In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
671.0, 1011.0
25.0, 25.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 17273997 In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway. PMID: 17273997 IRF-3 is a transcription factor that induces the IFN-beta gene and other genes, such as, IP-10 (IFN-gamma-induced protein-10. PMID: 17273997 In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
776.0, 948.0
23.0, 23.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 17273997 IRF-3 is a transcription factor that induces the IFN-beta gene and other genes, such as, IP-10 (IFN-gamma-induced protein-10.

Go back
203.0, 527.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e34 MO000042012

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m35*m19828*0.1

nodelay

--

true

0

false

PMID: 17273997 In pDC, CpG-A trigger a TLR-9MyD88TRAF3IRF-7IFN-alpha/beta pathway.

Go back
943.0, 383.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 MO000039077 e11

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c167 : 1
stoichiometry:c9 : 1

m184*m17258*m11*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.

Go back
199.0, 579.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e35 MO000042012

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m36*m19828*0.1

nodelay

--

true

0

false

PMID: 17273997, 17273999 In mDC and macrophages CpG-B trigger a TLR-9->MyD88->IRF-1->IFN-beta pathway.

Go back
203.0, 435.0
25.0, 25.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e36

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m1572*m37*0.1

nodelay

--

true

0

false

PMID: 17273997 In pDC, CpG-A trigger a TLR-9MyD88TRAF3IRF-7IFN-alpha/beta pathway.

Go back
203.0, 643.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m1572*m38*0.1

nodelay

--

true

0

false

PMID: 17273997, 17273999 In mDC and macrophages CpG-B trigger a TLR-9->MyD88->IRF-1->IFN-beta pathway.

Go back
88.0, 772.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e39 MO000007685

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m40*m970*0.1

nodelay

--

true

0

false

PMID: 17273997 In fact, the authors demonstrate that this pathway requires IRF-1, which is recruited and activated by MyD88. PMID: 17273997, 17018642 The study by Negishi et al. [6] demonstrates that IRF-1 interacts with the middle region of MyD88, overlapping with the region interacting with IRF-5 and IRF-4, but distinct from that binding IRF-7.

Go back
424.0, 436.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016963 e38

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m1872*m39*0.1

nodelay

--

true

0

false

PMID: 17273997 In pDC, CpG-A trigger a TLR-9->MyD88->TRAF3->IRF-7->IFN-alpha/beta pathway.

Go back
572.0, 732.0
23.0, 23.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000007702

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m42*m980*0.1

nodelay

--

true

0

false

PMID: 17273997 In pDC, CpG-A trigger a TLR-9->MyD88->TRAF3->IRF-7->IFN-alpha/beta pathway.

Go back
349.0, 989.0
21.0, 21.0

p36

p36

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).

Go back
312.0, 788.0
23.0, 23.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17273997 In fact, the authors demonstrate that this pathway requires IRF-1, which is recruited and activated by MyD88.

Go back
346.0, 858.0
28.0, 28.0

p38

p38

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e43

e39 e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).

Go back
479.0, 987.0
25.0, 25.0

p39

p39

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).

Go back
948.0, 488.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e17

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c168 : 1
stoichiometry:c12 : 1

m183*m18*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.

Go back
460.0, 1104.0
23.0, 23.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c107 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS). PMID: 17273997 In contrast, when IFN-gamma signaling occurs together with TLR-9 engagement, IRF-1 is not only induced but is also activated and migrates rapidly into the nucleus to mediate efficient induction of IFN-beta, iNOS and IL-12p35.

Go back
497.0, 1105.0
21.0, 21.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS). PMID: 17273997 In contrast, when IFN-gamma signaling occurs together with TLR-9 engagement, IRF-1 is not only induced but is also activated and migrates rapidly into the nucleus to mediate efficient induction of IFN-beta, iNOS and IL-12p35.

Go back
477.0, 517.0
21.0, 21.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e38 MO000039077 MO000000213

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1
stoichiometry:c111 : 1

m39*m17258*m184*0.1

nodelay

--

true

0

false

PMID: 17273997 Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types.

Go back
639.0, 607.0
25.0, 25.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m183*m49*0.1

nodelay

--

true

0

false

PMID: 17273997 Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types.

Go back
891.0, 595.0
25.0, 25.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e49

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m17*m63*0.1

nodelay

--

true

0

false

PMID: 17273997 Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types.

Go back
864.0, 288.0
23.0, 23.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007697 MO000016573

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m978*m1572*0.1

nodelay

--

true

0

false

PMID: 17273997, 16236719 Moreover, MyD88 also recruits IRF-4, which acts a negative regulator of TLR signaling.

Go back
512.0, 800.0
24.0, 24.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e42

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17273997 IRF-1 and IRF-7 are recruited and activated through MyD88, which simultaneously triggers a parallel signaling pathway for NF-kappaB and IRF-5 activation and secretion of proinflammatory cytokines. PMID: 17273997, 16932750 Simultaneous activation of IRF-7 by viral infection leads to IRF-7-mediated induction of IFN-alpha.

Go back
458.0, 806.0
26.0, 26.0

p47

p47

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e63

e41 e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).

Go back
412.0, 856.0
23.0, 23.0

p48

p48

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).

Go back
505.0, 901.0
21.0, 21.0

p49

p49

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 17273997 The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).

Go back
949.0, 453.0
22.0, 22.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000007700

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c14 : 1
stoichiometry:c13 : 1

m15*m979*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 also recruits IRF-5 and triggers a TRAF6 signaling pathway that leads to activation of NF-kappaB.

Go back
644.0, 904.0
23.0, 23.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17273997 Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types. PMID: 17273997, 16932750 Simultaneous activation of IRF-7 by viral infection leads to IRF-7-mediated induction of IFN-alpha.

Go back
300.0, 172.0
23.0, 23.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 MO000022224

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c134 : 1
stoichiometry:c133 : 1

m76904*m119368*0.1

nodelay

--

true

0

false

PMID: 17273997 Recent studies have identified pattern recognition receptors distinct from TLR, two of which, RIG-I (retinoic acid-inducible gene-I) and MDA-5 (melanoma differentiation-associated gene 5), are cytosolic RNA helicases that detect viral RNA.

Go back
332.0, 208.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e21

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m119368*m22*0.1

nodelay

--

true

0

false

PMID: 17273997 Recent studies have identified pattern recognition receptors distinct from TLR, two of which, RIG-I (retinoic acid-inducible gene-I) and MDA-5 (melanoma differentiation-associated gene 5), are cytosolic RNA helicases that detect viral RNA.

Go back
200.0, 304.0
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e70 e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m71*m72*0.1

nodelay

--

true

0

false

PMID: 17273997 In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
380.0, 204.0
23.0, 23.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000016608 MO000019331

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m73*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 17273997 In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
740.0, 528.0
24.0, 24.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e73 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m74*m977*0.1

nodelay

--

true

0

false

PMID: 17273997 In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.

Go back
460.0, 1192.0
23.0, 23.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

G010384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 17273997 Importantly, they found that IFN-gamma, despite its ability to induce high levels of IRF-1, does not trigger IRF-1 activation and nuclear translocation, resulting in suboptimal induction of IFN-beta, IL-12p35 and iNOS.

Go back
420.0, 1100.0
23.0, 23.0

p57

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

G012390

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 17273997, 9490414 Since IRF-1 has been shown to control NK- and T-cell development through induction of IL-15 [7], it is plausible that TLR-9 signaling also potentiates IL-15 secretion and IL-15-mediated NK- and T-cell responses to pathogenic infections.

Go back
504.0, 1076.0
23.0, 23.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 17273997, 17273999 In mDC and macrophages CpG-B trigger a TLR-9->MyD88->IRF-1->IFN-beta pathway. PMID: 17273997 In contrast, when IFN-gamma signaling occurs together with TLR-9 engagement, IRF-1 is not only induced but is also activated and migrates rapidly into the nucleus to mediate efficient induction of IFN-beta, iNOS and IL-12p35.

Go back
110.0, 1050.0
27.0, 27.0

p59

p59

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000017063

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1

m1956*0.1

nodelay

--

true

0

false

PMID: 17273997, 9490414 Since IRF-1 has been shown to control NK- and T-cell development through induction of IL-15 [7], it is plausible that TLR-9 signaling also potentiates IL-15 secretion and IL-15-mediated NK- and T-cell responses to pathogenic infections.

Go back
947.0, 539.0
25.0, 25.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e16 MO000000058

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m16*m17*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.

Go back
259.0, 1147.0
25.0, 25.0

p60

p60

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G012390

MO000017063

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c21 : 1

m95141*0.1

nodelay

--

true

0

false

PMID: 17273997, 9490414 Since IRF-1 has been shown to control NK- and T-cell development through induction of IL-15 [7], it is plausible that TLR-9 signaling also potentiates IL-15 secretion and IL-15-mediated NK- and T-cell responses to pathogenic infections.

Go back
112.0, 1340.0
24.0, 24.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e74 MO000016660

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m75*m1636*0.1

nodelay

--

true

0

false

PMID: 17273997 In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.

Go back
266.0, 1290.0
27.0, 27.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000145 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1

m129*m76*0.1

nodelay

--

true

0

false

PMID: 17273997 In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.

Go back
367.0, 1291.0
25.0, 25.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016656 e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c163 : 1

m1633*m77*0.1

nodelay

--

true

0

false

PMID: 17273997 In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.

Go back
533.0, 1241.0
21.0, 21.0

p64

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c165 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 17273997 In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.

Go back
794.0, 1058.0
27.0, 27.0

p7

p7

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e19

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17273997 The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction.

Go back
947.0, 992.0
23.0, 23.0

p8

p8

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 17273997 The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction.

Go back
703.0, 1131.0
25.0, 25.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c22 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 17273997 MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes. PMID: 17273997 Both NF-kappaB and IRF-5 induce transcription of pro-inflammatory cytokine genes (TNF-alpha, IL-6, IL-12p40).

Go back
979.0, 53.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.6568542494924, 412.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.0, 943.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
370.0, 1000.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
459.0, 1000.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.86234793301037, 1012.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.0, 1050.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 1050.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 1116.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.0, 1127.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.139025330787, 346.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.54511927984265, 401.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 500.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 456.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.0, 533.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.9999264508291, 509.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.4994021760781, 625.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 593.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.0, 565.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 608.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 627.99898944777

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 767.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.86234793301037, 780.4436087949382

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.0, 508.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
469.0, 783.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 691.7787824741549

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 832.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.0, 868.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 879.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 929.0097272694131

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.0, 912.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.5775375331502, 894.5536798306425

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.0, 913.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.0, 256.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.0, 464.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.0, 260.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
887.0, 300.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 184.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
323.0, 184.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
311.70318814531953, 75.880725191196

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0286400224819, 80.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.0, 220.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.9294846883888, 227.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
228.8307845767519, 275.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.0, 316.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 464.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 325.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
277.0, 232.90788395142502

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.5287597960348, 222.70513880117267

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.7394631990594, 221.02502083702987

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 227.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 272.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.0, 495.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.2044960296895, 550.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.0, 1204.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
138.0, 1204.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.0, 552.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.0, 1050.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 1088.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
435.0, 1123.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
435.4172239865221, 1050.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
292.0, 1160.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
124.0, 1085.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
141.80370958807373, 1304.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
124.0, 1314.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
136.0, 1352.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 1270.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 552.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.0, 1304.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
200.0, 1314.748021039078

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
380.0, 1269.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 1304.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 1304.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
554.0, 1252.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 1260.5777087639997

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
966.8646187432906, 267.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0492821445085, 472.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 564.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
959.0215632639866, 621.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 1004.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
989.0, 74.8335884449155

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.0, 1017.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
145.0, 1160.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.4560373723303, 1149.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.8954737212622, 1175.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.8340833560568, 1129.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.6098187424603, 1130.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.2973429588436, 1130.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
754.7075489304051, 1191.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 1319.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 1320.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1024.0, 68.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.0, 1320.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 1190.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
684.0, 1219.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.0, 1225.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
417.0, 76.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.0, 295.25414506028517

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.0, 295.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 89.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 155.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.9509778128281, 147.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 244.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 225.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 314.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 317.8

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
569.9999939619438, 68.00982898076857

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 86.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 78.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.0, 230.81219018771145

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 316.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 364.23999152002546

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 165.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.5294032646854, 133.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.0, 161.45123996684563

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.5924793943209, 364.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 436.94028500029066

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 322.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.6335403374912, 310.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.451643978432, 444.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 230.67147404648992

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.8470183397434, 230.78386300320423

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 156.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.0, 154.38873330800013

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 244.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 147.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 533.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
662.8102651883261, 498.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.0, 549.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.0, 498.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.8308170454446, 549.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0, 610.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 852.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0, 914.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 960.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 347.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0570138197744, 1036.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.2394443073428, 966.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
759.9402850002907, 971.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.0, 960.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
118.0, 540.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 540.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 507.57969700070595

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
115.0, 592.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.40780779051494, 545.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 592.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 396.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
171.8632244372984, 51.56438809004254

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.70599058880555, 32.032978306435155

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 448.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.2938715464503, 456.2862498176315

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.0649257556593, 599.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 656.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
117.97353065329379, 665.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
111.0, 723.2074857598645

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
119.0, 784.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.00996417963745, 315.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.0, 396.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 448.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 459.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 715.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.0, 763.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 744.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
327.1313708498985, 739.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.0, 785.7354436625493

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
373.13495279227135, 805.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.19320628004203, 686.9105157084268

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 886.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back