1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17275323.csml convertedTime:2009.07.01.11:00

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TLR signaling.
Authors Kawai T, Akira S.
Affiliation Department of Host Defense, Research Institute for Microbial Diseases, OsakaUniversity, Yamada-oka, Suita, Osaka, Japan.
Abstract The TLR family senses the molecular signatures of microbial pathogens, and playsa fundamental role in innate immune responses. TLRs signal via a common pathwaythat leads to the expression of diverse inflammatory genes. In addition, eachTLR elicits specific cellular responses to pathogens owing to differential usageof intracellular adapter proteins. Recent studies have revealed the importanceof the subcellular localization of TLRs in pathogen recognition and signaling.TLR signaling pathways is negatively regulated by a number of cellular proteinsto attenuate inflammation. Here, we describe recent advances in ourunderstanding of the regulation of TLR-mediated signaling.
PMID 17275323
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010384:IRF-1 G010660:opn G010779:ATF3 G011345:IL10 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000041:Tpl2 MO000000058:NF-kappaB MO000000065:RIP1 MO000000077:MAPKs MO000000210:IKK-alpha MO000000212:TRAF6 MO000000215:IkappaB MO000000276:AP-1 MO000000289:TNF-alpha MO000000331:PIP2 MO000001935:Btk MO000007384:IL-6 MO000007685:IRF-1 MO000007694:IRF-3 MO000007697:IRF-4 MO000007700:IRF-5 MO000007702:IRF-7 MO000008272:ROS MO000016566:IRAK-2 MO000016569:IRAK-M MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016591:A20 MO000016599:IKK-gamma MO000016608:IKK-i MO000016645:PKCepsilon MO000016653:RP105 MO000016661:IKK-alpha:IKK-beta:IKK-gamma MO000016665:IFNgamma MO000016882:LPS MO000016900:Caspase-8 MO000016962:TRAF1 MO000016963:TRAF3 MO000016964:TRAF4 MO000017004:SOCS-1 MO000017197:Pin1 MO000017291:integrins MO000018132:CD14 MO000019331:TBK1 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000021842:IRAK MO000022125:TAB2 MO000022131:MD-2 MO000022136:Ubc13 MO000022185:flagellin MO000022200:MD-1 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041541:TAB3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042128:TLR10 MO000042130:TLR11 MO000044794:ST2L MO000066718:SIGIRR MO000090987:T-bet e1: e10: e100:MyD88: TRAF6: IRF-5 {p} e101:ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}: OPN-i: IKK-alpha: TRAF3 e102:RIP1(m.s.){ub} e103:IRF-7 {nucleus} e104:IFN-alpha(h) e105:IRF-7 {p} e106:ARF6 GTPase e107: e108: e109: e11:TLR1:TLR2 e110:TRAM {p} e112:ARF6 GTPase {activated} e113:CD11b e114:LPS: CD14: TLR4: MD-2: TIRAP: MyD88 e115:PI5K {activated} e116:PI5K e117:RP105:MD-1 e118:RP105: MD-1: MD-2: TLR4 e119:MD-2: TLR4 e12:CD36 e120:SIGIRR: IRAK: TRAF6 e121:Triad3A e122:TLR9: Triad3A e123:TLR4: Triad3A e124:TLR9 {degraded} e125:TLR4 {degraded} e126:MyD88s e127:MyD88: MyD88s e128:TIRAP {p} e129:TIRAP{p}: SOCS-1 e13:TLR1:TLR2: CD36 e130:TIRAP {ub} e131:TIRAp {degraded} e132:TRIF: TRAF1 e133:TRAF1 {degraded} e134:TRAF4: TRAF6: TRIF e135:ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: OPN-i: IKK-alpha: TRAF3 e136:T-bet {activated} e137:IRF-5 {nucleus} e138:MyD88: TRAF6 e139:Pin1: IRF-3 {p339} e14:TLR6: TLR2 e140:IRF-3 {p339} e141:IRF-3{ub} e142:IRF-3 {degraded} e143:MyD88: IRF-4 e15:TLR6: TLR2: CD36 e16:triacyl-lipopeptide: TLR1:TLR2: CD36 e17:triacyl-lipopeptide e18:diacyl-lipopeptide e19:diacyl-lipopeptide: TLR6: TLR2: CD36 e2: e20:TLR1: TLR10 e21:TLR2: TLR10 e22:flagellin: TLR5 e23:profilin-like molecule e24:profilin-like molecule: TLR11 e25:loxoribidine e26:loxoribidine: TLR7 e27:ssRNA e28:ssRNA: TLR7 e29:imidazoquinolines e3: e30:ssRNA: TLR8 e31:imidazoquinolines: TLR8 e32:CpG DNA e33:CpG DNA: TLR9 e34:hemozoin e35:hemozoin: TLR9 e36:IRAK1 e37:TLR e38:ligand e39:ligand: TLR e4: e40:ligand: TLR: MyD88 e41:ligand: TLR: MyD88: IRAK-4 e42:ligand: TLR: MyD88: IRAK1 e43:ligand: TLR: MyD88: IRAK-M e44:ligand: TLR: MyD88: IRAK-2 e45:IRAK: TRAF6 e46:ligand: TLR: MyD88: IRAK e47:ligand: TLR: MyD88: IRAK {p} e48:Uev1A e49:IRAK { p} e5:CD14: TLR4: MD-2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS: CD14: TLR4: MD-2 e60: e61: e62: e63:IRAK: TRAF6: Ubc13: Uev1A e64:IRAK: TRAF6 {ub}: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3 e65:IRAK: TRAF6: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3 e66:IKK-alpha:IKK-beta:IKK-gamma {activated} e67:degraded IkappaB e68:IkappaB {p} e69:NF-kappaB {nucleus} e7: e70:MAPKs {activated} e71:AP-1 {activated} e72:IRAK: TRAF6: Ubc13: Uev1A: TAK1{ub}: TAB1: TAB2: TAB3 e73:IKK-gamma(m.s.){ub} e74:ERK {activated} e75:JNK {activated} e76:p38 {activated} e77:ABIN2 e78:ROS e79:diacyl-lipopeptide: TLR6: TLR2: CD36: TIRAP e8: e80:triacyl-lipopeptide: TLR1:TLR2: CD36: TIRAP e81:LPS: CD14: TLR4: MD-2: TIRAP e82:dsRNA:TLR3: TRIF e83:LPS: CD14: TLR4: MD-2: TRIF e84:dsRNA:TLR3: TRIF: TBK1: IKK-i e85:LPS: CD14: TLR4: MD-2: TRIF: TBK1: IKK-i e86:IRF-3{p}: IRF-3 e87:IRF-3{p}: IRF-3 {nucleus} e88:Type I IFN e89:TBK1: IKK-i: TRAF3 e9: e90:NF-kappaB {activated} e91:TRIF: TRAF6: RIP1 e92:ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 e93:ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p} e94:OPN-i e95:IL-12 p35 e96:NOS e97:MyD88: IRF1 e98:IRF-1 {nucleus} e99:MyD88: TRAF6: IRF-5

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p87 p88 p9 p90 p91 p93 p94 p95 p96 p97 p98 p99
Model Detail
773.0, 1265.0
37.0, 37.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p68 p71 p82

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
645.0, 1249.0
37.0, 37.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46 p77

p47

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
645.0, 1205.0
29.5, 29.5

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p42

p43

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
794.0, 1122.0
28.0, 28.0

IRF-1

--

G010384

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p81

--

true true true true

csml-variable:Double

m93359

10

false

infinite

0

unit false false false
TRANSFACG010384

--

Go back
943.0, 1275.0
26.0, 26.0

opn

--

G010660

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p110

--

true true true true

csml-variable:Double

m93592

10

false

infinite

0

unit false false false
TRANSFACG010660

--

Go back
845.0, 1101.0
30.0, 30.0

ATF3

--

G010779

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p117

--

true true true true

csml-variable:Double

m93686

10

false

infinite

0

unit false false false
TRANSFACG010779

--

Go back
772.0, 1156.0
32.0, 32.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p76

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
380.0, 356.0
32.0, 32.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
406.0, 526.0
28.0, 28.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
389.0, 421.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
399.0, 279.0
34.0, 34.0

Tpl2

--

MO000000041

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000041

--

Go back
1135.0, 883.0
42.0, 42.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
810.0, 738.0
36.0, 36.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
864.0, 744.0
31.0, 31.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1105.0, 1329.0
38.0, 38.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
821.0, 477.0
38.0, 38.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p63 p65 p83 p95 p107

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1055.0, 719.0
42.0, 42.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
945.0, 833.0
30.0, 30.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
518.0, 1138.0
28.0, 28.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
926.0, 1606.0
28.0, 28.0

PIP2

--

MO000000331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p87 p121 p122

p52

true true true true

csml-variable:Double

m290229

10

false

infinite

0

unit false false false
TRANSPATHMO000000331

--

Go back
577.0, 745.0
29.0, 29.0

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p101 p119 p120

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
510.0, 1194.0
28.0, 28.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
577.0, 925.0
38.0, 38.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
522.0, 1342.0
36.0, 36.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57 p58 p114

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
793.0, 285.0
29.0, 29.0

IRF-4

--

MO000007697

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p118

true true true true

csml-variable:Double

m978

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007697

--

Go back
720.0, 780.0
32.0, 32.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
1048.0, 1020.0
32.0, 32.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65 p74

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
505.0, 1241.0
30.0, 30.0

ROS

--

MO000008272

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m1063

10

false

infinite

0

unit false false false
TRANSPATHMO000008272

--

Go back
1099.0, 339.0
42.0, 42.0

IRAK-2

--

MO000016566

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m1569

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
1044.0, 312.0
40.0, 40.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
713.0, 361.0
38.0, 38.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

p111

p21 p80 p83 p90 p100 p118

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1127.0, 519.0
50.0, 50.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1141.0, 581.0
29.0, 29.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
1140.0, 472.0
31.0, 31.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
1136.0, 944.0
32.0, 32.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
377.0, 925.0
38.0, 38.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p56 p62

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
606.0, 426.0
36.0, 36.0

PKCepsilon

--

MO000016645

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m1629

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016645

--

Go back
290.0, 170.0
27.0, 27.0

RP105

--

MO000016653

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93

true true true true

csml-variable:Double

m1632

10

false

infinite

0

unit false false false
InterProIPR000483
TRANSPATHMO000016653

--

Go back
978.0, 714.0
60.0, 60.0

IKK-alpha:IKK-beta:IKK-gamma

--

MO000016661

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m1637

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
54.0, 990.0
32.0, 32.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80 p81

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
170.0, 90.0
35.5, 35.5

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
721.0, 821.0
31.0, 31.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p106

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
669.0, 757.0
30.0, 30.0

TRAF1

--

MO000016962

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p105

true true true true

csml-variable:Double

m1871

10

false

infinite

0

unit false false false
InterProIPR002083
TRANSPATHMO000016962

--

Go back
583.0, 1127.0
34.0, 34.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62 p67 p76

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
749.0, 473.0
30.0, 30.0

TRAF4

--

MO000016964

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p107

true true true true

csml-variable:Double

m1873

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016964

--

Go back
497.0, 821.0
30.0, 30.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

p103

p102

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
493.0, 1513.0
30.0, 30.0

Pin1

--

MO000017197

cso30:c:Protein

cso30:i:CC_CellComponent

--

p115

p113

true true true true

csml-variable:Double

m2065

10

false

infinite

0

unit false false false
InterProIPR000297
TRANSPATHMO000017197

--

Go back
1076.0, 1488.0
31.0, 31.0

integrins

--

MO000017291

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88 p91

true true true true

csml-variable:Double

m2142

10

false

infinite

0

unit false false false
TRANSPATHMO000017291

--

Go back
220.0, 248.0
32.0, 32.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
327.0, 887.0
34.0, 34.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p56 p62

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
252.0, 216.0
32.0, 32.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p96

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
239.0, 331.0
34.0, 34.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p9

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
243.0, 601.0
32.0, 32.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p5 p10

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
423.0, 1315.0
34.0, 34.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
240.0, 1032.0
32.0, 32.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
243.0, 847.0
34.0, 34.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
894.0, 322.0
36.0, 36.0

IRAK

--

MO000021842

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p95

true true true true

csml-variable:Double

m6176

10

false

infinite

0

unit false false false
TRANSPATHMO000021842

--

Go back
1135.0, 623.0
34.0, 34.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
241.0, 289.0
37.5, 37.5

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
978.0, 446.0
36.0, 36.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p40

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
136.0, 996.0
40.0, 40.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
331.0, 175.0
26.0, 26.0

MD-1

--

MO000022200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93

true true true true

csml-variable:Double

m6500

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022200

--

Go back
139.0, 1239.0
42.0, 42.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
337.0, 729.0
38.0, 38.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p51 p52 p101 p119 p120

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1036.0, 264.0
39.5, 39.5

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
303.0, 839.0
34.0, 34.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

p106

p53 p54 p63 p105 p107

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
648.0, 356.0
32.0, 32.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
346.0, 1246.0
36.0, 36.0

dsRNA:TLR3

--

MO000041446

cso30:c:Complex

cso30:i:CC_CellComponent

--

p13

p53

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
624.0, 1388.0
32.0, 32.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57 p58

p59

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
1134.0, 670.0
36.0, 36.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
462.0, 1394.0
36.0, 36.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
349.0, 1293.0
29.0, 29.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p19 p97

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
486.0, 1350.0
36.0, 36.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
238.0, 934.0
36.0, 36.0

TLR10

--

MO000042128

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10

true true true true

csml-variable:Double

m19942

10

false

infinite

0

unit false false false
TRANSPATHMO000042128

--

Go back
237.0, 1125.0
30.0, 30.0

TLR11

--

MO000042130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m19944

10

false

infinite

0

unit false false false
TRANSPATHMO000042130

--

Go back
708.0, 252.0
32.0, 32.0

ST2L

--

MO000044794

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p90

true true true true

csml-variable:Double

m22464

10

false

infinite

0

unit false false false
TRANSPATHMO000044794

--

Go back
817.0, 369.0
30.0, 30.0

SIGIRR

--

MO000066718

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p95

true true true true

csml-variable:Double

m41575

10

false

infinite

0

unit false false false
TRANSPATHMO000066718

--

Go back
744.0, 1320.0
32.0, 32.0

T-bet

--

MO000090987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p109

true true true true

csml-variable:Double

m64461

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000090987

--

Go back
227.51160282260355, 181.38956381153073
1025.9807226274447, 1489.7240092550503

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
237.39685564842853, 204.15930548453505
994.4895026921334, 1398.9670951847072

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
887.625, 980.5
32.479545075820695, 39.7708715214131

MyD88: TRAF6: IRF-5 {p}

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

p112

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1204.875, 1263.5
47.18044595338595, 65.83318040007342

ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}: OPN-i: IKK-alpha: TRAF3

--

e101

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p67

p108

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
842.0, 850.0
36.0, 36.0

RIP1(m.s.){ub}

--

e102

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

p63

true true true true

csml-variable:Double

m109

10

false

infinite

0

unit false false false
TRANSPATHMO000048754

--

Go back
1008.0, 1220.0
32.0, 32.0

IRF-7 {nucleus}

--

e103

cso30:c:Protein

cso30:i:CC_CellComponent

--

p108

p70 p71

true true true true

csml-variable:Double

m110

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
898.0, 1210.0
35.0, 35.0

IFN-alpha(h)

--

e104

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p70

--

true true true true

csml-variable:Double

m111

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
1081.5, 1128.125
53.64, 40.230000000000004

IRF-7 {p}

--

e105

cso30:c:Protein

cso30:i:CC_Cytosol

--

p74

p75

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
993.5, 1553.125
36.47514590460858, 22.49300664117529

ARF6 GTPase

--

e106

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p88

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
332.0, 1200.3047237972437
200.6490053666573, 334.9818140443344

--

e107

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false true false

--

Go back
332.0, 1200.3047237972437
200.6490053666573, 334.9818140443344

--

e108

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false true false

--

Go back
332.0, 1200.3047237972437
200.6490053666573, 334.9818140443344

--

e109

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false true false

--

Go back
238.0, 378.0
36.0, 36.0

TLR1:TLR2

--

e11

cso30:c:Complex

cso30:i:CC_CellComponent

--

p3

p4

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
TRANSPATHMO000075483

--

Go back
613.5, 475.125
45.0, 33.75

TRAM {p}

--

e110

cso30:c:Protein

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
1009.5, 1497.125
36.47514590460858, 22.49300664117529

ARF6 GTPase {activated}

--

e112

cso30:c:Protein

cso30:i:CC_Cytosol

--

p88

p122

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
1120.5, 1376.125
39.48178707989535, 24.34710203260213

CD11b

--

e113

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p121

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
606.875, 158.5
42.41406680124794, 59.18241879243897

LPS: CD14: TLR4: MD-2: TIRAP: MyD88

--

e114

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

p120

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
1124.5, 1420.125
39.37311330247535, 24.280086536526465

PI5K {activated}

--

e115

cso30:c:Protein

cso30:i:CC_Cytosol

--

p91

p87

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
1128.5, 1496.125
39.37311330247535, 24.280086536526465

PI5K

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p91

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
377.625, 169.5
36.75, 45.0

RP105:MD-1

--

e117

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p93

p94

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
431.875, 173.5
32.25, 45.0

RP105: MD-1: MD-2: TLR4

--

e118

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p94

p2

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
343.875, 205.5
32.25, 45.0

MD-2: TLR4

--

e119

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p94

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
318.5, 530.125
35.88, 26.90999999999999

CD36

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4 p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
759.875, 397.5
32.25, 45.0

SIGIRR: IRAK: TRAF6

--

e120

cso30:c:Complex

cso30:i:CC_Cytosol

--

p95

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
402.125, 693.5
27.75, 45.0

Triad3A

--

e121

cso30:c:Protein

cso30:i:CC_Cytosol

--

p98 p99

p96 p97

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
417.625, 1178.5
28.96029828361939, 35.46158973504416

TLR9: Triad3A

--

e122

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p97

p98

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
301.625, 237.5
36.75, 45.0

TLR4: Triad3A

--

e123

cso30:c:Complex

cso30:i:CC_Cytosol

--

p96

p99

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
388.5, 1077.25
30.594485927627797, 29.57466973004021

TLR9 {degraded}

--

e124

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p98

--

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
335.5, 312.25
32.66226306720275, 31.573520964962665

TLR4 {degraded}

--

e125

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p99

--

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
650.5, 523.125
34.28, 25.709999999999997

MyD88s

--

e126

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p100

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
697.625, 593.5
36.75, 45.0

MyD88: MyD88s

--

e127

cso30:c:Complex

cso30:i:CC_Cytosol

--

p100

--

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
485.5, 783.125
33.160000000000004, 24.869999999999994

TIRAP {p}

--

e128

cso30:c:Protein

cso30:i:CC_Cytosol

--

p101 p119 p120

p102

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
449.625, 901.5
36.75, 45.0

TIRAP{p}: SOCS-1

--

e129

cso30:c:Complex

cso30:i:CC_Cytosol

--

p102

p103

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
241.625, 425.5
36.75, 45.0

TLR1:TLR2: CD36

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p7

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
464.5, 968.125
38.44000000000001, 28.83

TIRAP {ub}

--

e130

cso30:c:Protein

cso30:i:CC_Cytosol

--

p103

p104

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
561.0, 981.5
30.0, 29.0

TIRAp {degraded}

--

e131

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p104

--

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
675.75, 821.0
24.5, 30.0

TRIF: TRAF1

--

e132

cso30:c:Complex

cso30:i:CC_Cytosol

--

p105

p106

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
721.0, 873.5
30.0, 29.0

TRAF1 {degraded}

--

e133

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p106

p58 p64

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
770.25, 593.0
27.59212699577904, 38.50064231969168

TRAF4: TRAF6: TRIF

--

e134

cso30:c:Complex

cso30:i:CC_Cytosol

--

p107

p64

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
1206.5, 1362.0
43.0, 60.0

ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: OPN-i: IKK-alpha: TRAF3

--

e135

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p108

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
848.0, 1320.0
32.0, 32.0

T-bet {activated}

--

e136

cso30:c:Protein

cso30:i:CC_CellComponent

--

p109

p110

true true true true

csml-variable:Double

m143

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000090987

--

Go back
932.0, 1104.0
32.0, 32.0

IRF-5 {nucleus}

--

e137

cso30:c:Protein

cso30:i:CC_CellComponent

--

p112

--

true true true true

csml-variable:Double

m144

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
933.5, 962.0
29.90134977503749, 36.61389768371938

MyD88: TRAF6

--

e138

cso30:c:Complex

cso30:i:CC_Cytosol

--

p112

--

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
626.75, 1507.0
34.94342609565072, 42.78786868855191

Pin1: IRF-3 {p339}

--

e139

cso30:c:Complex

cso30:i:CC_Cytosol

--

p113

p115

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
238.5, 647.125
43.88, 32.91

TLR6: TLR2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
575.0, 1462.75
34.480000000000004, 25.86

IRF-3 {p339}

--

e140

cso30:c:Protein

cso30:i:CC_Cytosol

--

p114

p113

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
613.0, 1557.75
37.52, 28.14

IRF-3{ub}

--

e141

cso30:c:Protein

cso30:i:CC_Cytosol

--

p115

p116

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
733.0, 1557.5
30.0, 29.0

IRF-3 {degraded}

--

e142

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p116

--

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
709.75, 677.0
44.872437927012164, 54.94584235960674

MyD88: IRF-4

--

e143

cso30:c:Complex

cso30:i:CC_Cytosol

--

p118

p83

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
237.5, 691.125
45.0, 33.75

TLR6: TLR2: CD36

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
236.5, 490.125
47.72, 35.79

triacyl-lipopeptide: TLR1:TLR2: CD36

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p50

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
145.5, 453.375
45.0, 29.25

triacyl-lipopeptide

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
145.5, 813.375
45.0, 29.25

diacyl-lipopeptide

--

e18

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
227.5, 791.125
56.199999999999996, 42.15

diacyl-lipopeptide: TLR6: TLR2: CD36

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p51 p101

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
227.51160282260355, 181.38956381153073
1025.9807226274447, 1489.7240092550503

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
229.5, 983.125
45.0, 33.75

TLR1: TLR10

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
237.5, 887.125
45.0, 33.75

TLR2: TLR10

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
219.5, 1073.125
49.16, 36.86999999999999

flagellin: TLR5

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
137.5, 1121.375
45.0, 29.25

profilin-like molecule

--

e23

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
230.5, 1169.125
50.120000000000005, 37.589999999999996

profilin-like molecule: TLR11

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
97.5, 1439.25
45.0, 25.5

loxoribidine

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
373.5, 1443.125
45.0, 33.75

loxoribidine: TLR7

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
93.5, 1635.625
45.0, 24.75

ssRNA

--

e27

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p15 p16

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
332.5, 1476.125
54.28, 40.71

ssRNA: TLR7

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p73

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
381.5, 1723.25
45.0, 25.5

imidazoquinolines

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p17

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
248.03121727515224, 201.9091782640796
984.9414937223471, 1448.6847803499525

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
391.5, 1482.125
57.96, 43.47

ssRNA: TLR8

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
452.5, 1443.125
54.6, 40.95

imidazoquinolines: TLR8

--

e31

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
93.5, 1392.125
45.0, 15.75

CpG DNA

--

e32

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p18

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
373.5, 1344.125
53.79999999999999, 40.35

CpG DNA: TLR9

--

e33

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p72 p78 p79 p109

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
141.5, 1319.25
45.0, 25.5

hemozoin

--

e34

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p19

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
467.5, 1312.125
41.96, 31.469999999999995

hemozoin: TLR9

--

e35

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
988.0, 336.0
40.0, 40.0

IRAK1

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p65

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000046974

--

Go back
793.375, 205.5
29.25, 45.0

TLR

--

e37

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p20

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
791.5, 86.375
40.95782073813708, 26.622583479789107

ligand

--

e38

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
838.375, 197.5
27.042589344442007, 52.34049550537163

ligand: TLR

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
285.99250401236804, 237.81850355604013
909.0189202479163, 1376.8661297660306

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
886.375, 185.5
35.38220784915589, 68.48169261126947

ligand: TLR: MyD88

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21 p29

p22 p23 p24 p25 p27

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1112.375, 162.5
39.03206533654901, 75.54593290944966

ligand: TLR: MyD88: IRAK-4

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p65

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1177.375, 151.5
37.30568954176715, 72.2045604034203

ligand: TLR: MyD88: IRAK1

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1203.375, 260.5
40.663286559964924, 78.70313527735146

ligand: TLR: MyD88: IRAK-M

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1195.375, 393.5
40.29626178469634, 77.99276474457356

ligand: TLR: MyD88: IRAK-2

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
945.625, 501.5
36.75, 45.0

IRAK: TRAF6

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p30

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
938.375, 173.5
36.05508660381496, 69.78403858802895

ligand: TLR: MyD88: IRAK

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p28

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1053.375, 168.5
36.90468099101074, 71.42841482131111

ligand: TLR: MyD88: IRAK {p}

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1067.0, 451.0
33.0, 33.0

Uev1A

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
HGNCUBE2V1
OMIM602995
ProteomeHumanPSD/UBE2V1
RefSeqNM_001032288
TRANSPATHMO000087842
UnigeneHs.420529
UniProtQ13404-1

--

Go back
889.5, 443.125
45.0, 33.75

IRAK { p}

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

p26

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
230.5, 166.0
42.598400266622235, 52.16130644892518

CD14: TLR4: MD-2

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
621.1015803805026, 1067.6235963452827
468.15363262062, 424.56390891292796

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
671.6656598814261, 1077.685143767679
273.743464884311, 411.4869918006199

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
627.204141699579, 1073.2902604272829
455.9485099824669, 413.2305807489274

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
628.075936173733, 1074.162054901436
454.2049210341586, 411.4869918006199

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
621.1015803805026, 1067.6235963452827
468.15363262062, 424.56390891292796

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
621.1015803805026, 1067.6235963452827
468.15363262062, 424.56390891292796

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
628.075936173733, 1074.162054901436
454.2049210341586, 411.4869918006199

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
962.8450142488136, 1241.9824911760543
29.24766669409471, 26.47683511254894

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
886.1271005232751, 1364.0337175575949
82.8204750446162, 74.97432477723163

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
621.1015803805026, 1067.6235963452827
468.15363262062, 424.56390891292796

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
487.625, 173.5
56.6570154974171, 69.37593734377604

LPS: CD14: TLR4: MD-2

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p41 p42 p43 p44 p45 p46 p47 p48 p49 p52 p54 p85 p117

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
731.442757470003, 1256.2962892657288
14.825737665589436, 7.138318135283811

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
730.9476841238887, 1235.0081353828236
50.745017976691386, 91.34103235804442

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
752.2358380067941, 1294.416936916512
7.92117353782499, 7.92117353782499

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1067.75, 496.5
48.60497237569061, 54.005524861878456

IRAK: TRAF6: Ubc13: Uev1A

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p33

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
826.0, 562.0
60.911602209944746, 67.67955801104972

IRAK: TRAF6 {ub}: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p39

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
976.75, 557.5
54.3232044198895, 60.35911602209945

IRAK: TRAF6: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p32

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1042.0, 634.0
60.0, 60.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p34

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1128.5, 833.25
38.900057438253874, 37.60338885697875

degraded IkappaB

--

e67

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1125.5, 775.125
45.0, 33.75

IkappaB {p}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
971.0, 1139.0
42.0, 42.0

NF-kappaB {nucleus}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p77

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
240.9914930396377, 187.38433099222576
1006.1674459673347, 1425.713281370689

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
864.0, 784.0
31.0, 31.0

MAPKs {activated}

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p38

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
997.0, 789.0
30.0, 30.0

AP-1 {activated}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
918.5, 644.0
51.66470912093962, 72.09029179665994

IRAK: TRAF6: Ubc13: Uev1A: TAK1{ub}: TAB1: TAB2: TAB3

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p31 p37

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1085.0, 981.0
38.0, 38.0

IKK-gamma(m.s.){ub}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000048690

--

Go back
424.0, 392.0
32.0, 32.0

ERK {activated}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

--

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
437.0, 477.0
30.0, 30.0

JNK {activated}

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

--

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
438.0, 590.0
28.0, 28.0

p38 {activated}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
436.5, 266.0
22.308714026967195, 36.176293016703575

ABIN2

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
648.0, 1296.0
32.0, 32.0

ROS

--

e78

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p48

p49

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSFACG012563

--

Go back
228.0, 741.5
48.8, 36.6

diacyl-lipopeptide: TLR6: TLR2: CD36: TIRAP

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p51

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
244.58613043084682, 212.5467927306896
965.2284201767042, 1401.5116660965755

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
230.0, 551.5
44.96, 33.72

triacyl-lipopeptide: TLR1:TLR2: CD36: TIRAP

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p50

p119

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
546.5, 162.0
43.0, 60.0

LPS: CD14: TLR4: MD-2: TIRAP

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p52

p90

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
350.0, 1207.5
44.319999999999986, 33.24000000000001

dsRNA:TLR3: TRIF

--

e82

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p53

p55

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
658.5, 145.0
50.0075243163883, 69.77794090658837

LPS: CD14: TLR4: MD-2: TRIF

--

e83

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
454.5, 1242.0
43.0, 60.0

dsRNA:TLR3: TRIF: TBK1: IKK-i

--

e84

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55

p58

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
713.0, 130.0
54.705882352941174, 91.17647058823529

LPS: CD14: TLR4: MD-2: TRIF: TBK1: IKK-i

--

e85

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

p57

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
690.5, 1435.0
34.980169971671394, 42.83286118980171

IRF-3{p}: IRF-3

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p60

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
658.5, 1339.0
34.980169971671394, 42.83286118980171

IRF-3{p}: IRF-3 {nucleus}

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

p61 p68

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
853.5, 1360.0
45.0, 24.0

Type I IFN

--

e88

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p61 p72 p73 p75

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
491.875, 1025.5
32.25, 45.0

TBK1: IKK-i: TRAF3

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

p74

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
254.17183014073788, 237.7092544691536
960.8216229776117, 1383.1311917827668

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1055.0, 895.0
42.0, 42.0

NF-kappaB {activated}

--

e90

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p64

p36

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
893.875, 894.5
36.95324830244082, 51.56267204991741

TRIF: TRAF6: RIP1

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p64

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1185.875, 1075.5
52.55445953385943, 73.3318040007341

ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7

--

e92

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p65

p66

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1192.875, 1165.5
54.92186639750413, 76.63516241512202

ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p66

p67

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1092.5, 1291.125
30.003018716039445, 18.50186154155766

OPN-i

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p67

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
844.0, 1405.0
39.86159169550173, 21.259515570934255

IL-12 p35

--

e95

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p78

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
897.0, 1404.0
45.57093425605536, 24.304498269896197

NOS

--

e96

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p79

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
712.625, 1049.5
30.07894517580403, 36.83136143976004

MyD88: IRF1

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

p111

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
849.0, 1181.0
38.0, 38.0

IRF-1 {nucleus}

--

e98

cso30:c:Protein

cso30:i:CC_CellComponent

--

p111

p82

true true true true

csml-variable:Double

m105

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
757.625, 941.5
36.75, 45.0

MyD88: TRAF6: IRF-5

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83

p84

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
137.0, 257.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018132 MO000022131 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1

m2828*m6438*m3961*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR4, together with its extracellular components such as MD-2 and CD14, recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, which causes septic shock.

Go back
85.0, 889.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000042128

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m3964*m19942*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 In addition, human TLR10 is thought to heterodimerize with TLR2 and TLR1, although a ligand for these heterodimers remains unknown.

Go back
709.0, 517.0
30.0, 30.0

p100

p100

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e126

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1
stoichiometry:c295 : 1

m1572*m133*0.1

nodelay

--

true

0

false

PMID: 17275323 MyD88s forms a heterodimer with MyD88.

Go back
493.0, 729.0
30.0, 30.0

p101

p101

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000022528 MO000001935 e19

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c296 : 1
stoichiometry:c297 : 1
stoichiometry:c300 : 1
stoichiometry:c298 : 1

m6810*m367*m19*0.1

nodelay

--

true

0

false

PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.

Go back
449.0, 825.0
30.0, 30.0

p102

p102

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e128 MO000017004

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c302 : 1
stoichiometry:c303 : 1
stoichiometry:c304 : 1

m135*m1906*0.1

nodelay

--

true

0

false

PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.

Go back
497.0, 925.0
30.0, 30.0

p103

p103

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e129

MO000017004 e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c305 : 1
stoichiometry:c306 : 1
stoichiometry:c307 : 1

m136*0.1

nodelay

--

true

0

false

PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.

Go back
513.0, 985.0
30.0, 30.0

p104

p104

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e130

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c308 : 1
stoichiometry:c309 : 1

m137*0.1

nodelay

--

true

0

false

PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.

Go back
569.0, 849.0
30.0, 30.0

p105

p105

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000016962

e132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1

m18998*m1871*0.1

nodelay

--

true

0

false

PMID: 17275323, 16323247 TRAF1 interacts with TRIF and overexpression of TRIF causes Caspase 8-dependent cleavage of TRAF1.

Go back
665.0, 873.0
30.0, 30.0

p106

p106

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e132 MO000016900

e133 MO000041125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c316 : 1
stoichiometry:c314 : 1
stoichiometry:c315 : 1

m139*m1815*0.1

nodelay

--

true

0

false

PMID: 17275323, 16323247 TRAF1 interacts with TRIF and overexpression of TRIF causes Caspase 8-dependent cleavage of TRAF1.

Go back
769.0, 521.0
30.0, 30.0

p107

p107

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016964 MO000000212 MO000041125

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c320 : 1
stoichiometry:c321 : 1
stoichiometry:c322 : 1

m1873*m183*m18998*0.1

nodelay

--

true

0

false

PMID: 17275323, 16052631 TRAF4 interacts with TRIF and TRAF6, and its overexpression results in inhibition of NF-kappaB activation induced by TRIF and TRAF6.

Go back
1061.0, 1213.0
30.0, 30.0

p108

p108

cso30:i:ME_Translocation

cso30:i:CC_NuclearEnvelopeLumen

--

e101

e135 e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c324 : 1
stoichiometry:c325 : 1
stoichiometry:c326 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17275323 In this complex, IRF7 is directly phosphorylated by IRAK1, and then translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.

Go back
797.0, 1321.0
30.0, 30.0

p109

p109

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000090987 e33

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c327 : 1
stoichiometry:c331 : 1
stoichiometry:c328 : 1

m64461*m33*0.1

nodelay

--

true

0

false

PMID: 17275323 In pDC, OPN expression is upregulated by TLR9 ligand through T-bet, a master transcription factor driving Th1 differentiation.

Go back
141.0, 1077.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588, 16829963 TLR5 is expressed abundantly in intestinal CD11c-positive lamina propria cells where it senses bacterial flagellin.

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913.0, 1321.0
30.0, 30.0

p110

p110

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e136

G010660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c329 : 1
stoichiometry:c330 : 1

m143*0.1

nodelay

--

true

0

false

PMID: 17275323 In pDC, OPN expression is upregulated by TLR9 ligand through T-bet, a master transcription factor driving Th1 differentiation.

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833.0, 1133.0
30.0, 30.0

p111

p111

cso30:i:ME_Translocation

cso30:i:CC_NuclearOuterMembrane

--

e97

e98 MO000016573

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c332 : 1
stoichiometry:c333 : 1
stoichiometry:c334 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.

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877.0, 1065.0
30.0, 30.0

p112

p112

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e100

e137 e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c335 : 1
stoichiometry:c336 : 1
stoichiometry:c337 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation.

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549.0, 1513.0
30.0, 30.0

p113

p113

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017197 e140

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c341 : 1
stoichiometry:c343 : 1
stoichiometry:c344 : 1

m2065*m147*0.1

nodelay

--

true

0

false

PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.

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533.0, 1417.0
30.0, 30.0

p114

p114

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694

e140

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c340 : 1
stoichiometry:c342 : 1

m977*0.1

nodelay

--

true

0

false

PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.

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529.0, 1577.0
30.0, 30.0

p115

p115

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e139

MO000017197 e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c360 : 1
stoichiometry:c345 : 1
stoichiometry:c346 : 1

m146*0.1

nodelay

--

true

0

false

PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.

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677.0, 1565.0
30.0, 30.0

p116

p116

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e141

e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c347 : 1
stoichiometry:c348 : 1

m148*0.1

nodelay

--

true

0

false

PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.

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789.0, 1085.0
30.0, 30.0

p117

p117

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G010779

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c350 : 1
stoichiometry:c349 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17275323 LPS stimulation leads to the expression of ATF3, a member of the ATF/CREB family of transcription factors.

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745.0, 305.0
30.0, 30.0

p118

p118

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000007697

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c351 : 1
stoichiometry:c352 : 1
stoichiometry:c353 : 1

m1572*m978*0.1

nodelay

--

true

0

false

PMID: 17275323, 16236719 IRF4 is reported to bind MyD88.

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453.0, 697.0
30.0, 30.0

p101

p119

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000001935 e80 MO000022528

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c356 : 1
stoichiometry:c357 : 1
stoichiometry:c299 : 1
stoichiometry:c301 : 1

m367*m86*m6810*0.1

nodelay

--

true

0

false

PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.

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149.0, 1173.0
30.0, 30.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e23 MO000042130

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m23*m19944*0.1

nodelay

--

true

0

false

PMID: 17275323 Mouse TLR11 recognizes as yet unknown components of uropathogenic bacteria, and a profilin-like molecule of the protozoan parasite Toxoplasma gondii.

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565.0, 685.0
30.0, 30.0

p101

p120

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000001935 e114 MO000022528

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c355 : 1
stoichiometry:c358 : 1
stoichiometry:c359 : 1

m367*m121*m6810*0.1

nodelay

--

true

0

false

PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.

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885.0, 1497.0
30.0, 30.0

p87

p121

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e113

MO000000331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c363 : 1

m120*0.1

nodelay

--

true

0

false

PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.

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961.0, 1525.0
30.0, 30.0

p87

p122

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e112

MO000000331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c364 : 1

m119*0.1

nodelay

--

true

0

false

PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.

Go back
261.0, 1269.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17275323 TLR3 was shown to recognize double stranded RNA (dsRNA), which is produced by many viruses during replication.

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229.0, 1445.0
30.0, 30.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e25 MO000042126

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m25*m19940*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single stranded RNA (ssRNA) derived from various viruses and small interfering RNA.

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229.0, 1489.0
30.0, 30.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m19940*m27*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single stranded RNA (ssRNA) derived from various viruses and small interfering RNA.

Go back
277.0, 1569.0
30.0, 30.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042007 e27

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m19823*m27*0.1

nodelay

--

true

0

false

PMID: 17275323 Human TLR8, which has the highest homology to TLR7, participates in the recognition of imidazoquinolines and ssRNA.

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389.0, 1577.0
30.0, 30.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042007 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m19823*m29*0.1

nodelay

--

true

0

false

PMID: 17275323 Human TLR8, which has the highest homology to TLR7, participates in the recognition of imidazoquinolines and ssRNA.

Go back
233.0, 1385.0
30.0, 30.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m19828*m32*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from the malaria parasite.

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221.0, 1321.0
30.0, 30.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m19828*m34*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from the malaria parasite.

Go back
241.0, 85.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e5 e118

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c274 : 1
stoichiometry:c7 : 1

m155666*m5*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR4, together with its extracellular components such as MD-2 and CD14, recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, which causes septic shock. PMID: 17275323, 9686597 the RP105-MD-1 complex interacts with a TLR4-MD-2 complex to prevent LPS binding to TLR4-MD-2.

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725.0, 85.0
30.0, 30.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e38 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m38*m37*0.1

nodelay

--

true

0

false

PMID: 17275323 Following stimulation, all TLRs except for TLR3 recruit MyD88, IRAKs and TRAF6 to activate the Ubc13/TAK1 pathway.

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825.0, 305.0
30.0, 30.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 MO000016573

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c65 : 1

m39*m1572*0.1

nodelay

--

true

0

false

PMID: 17275323 Following stimulation, all TLRs except for TLR3 recruit MyD88, IRAKs and TRAF6 to activate the Ubc13/TAK1 pathway.

Go back
985.0, 281.0
30.0, 30.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000039077

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c78 : 1
stoichiometry:c68 : 1

m40*m17258*0.1

nodelay

--

true

0

false

PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.

Go back
1089.0, 249.0
30.0, 30.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 e36

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m40*m36*0.1

nodelay

--

true

0

false

PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.

Go back
1125.0, 285.0
30.0, 30.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000016569

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m40*m1571*0.1

nodelay

--

true

0

false

PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.

Go back
1105.0, 421.0
30.0, 30.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e40 MO000016566

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m40*m1569*0.1

nodelay

--

true

0

false

PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.

Go back
893.0, 509.0
30.0, 30.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e49 MO000016964

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c88 : 1
stoichiometry:c338 : 1
stoichiometry:c84 : 1

m183*m49*0.1

nodelay

--

true

0

false

PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family. PMID: 17275323 TRAF4 may serve to antagonize TRAF6 function by preventing recruitment of TRAF6 to the adapter complex.

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901.0, 273.0
30.0, 30.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000021842

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m40*m6176*0.1

nodelay

--

true

0

false

PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.

Go back
937.0, 273.0
30.0, 30.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.

Go back
789.0, 445.0
30.0, 30.0

p29

p29

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e47

e49 e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.

Go back
116.0, 410.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019396 MO000019397

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m3963*m3964*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.

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1009.0, 509.0
30.0, 30.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022136 e48 e45

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m6443*m48*m45*0.1

nodelay

--

true

0

false

PMID; 17275323, 16056267 TRAF6, an E3 ligase, forms a complex with Ubc13 and Uev1A to promote the synthesis of lysine 63-linked polyubiquitin chains, which in turn activate TAK1, a MAPKKK.

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993.0, 661.0
30.0, 30.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016661 e72

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m1637*m74*0.1

nodelay

--

true

0

false

PMID: 17275323 TAK1, in combination with TAB1, TAB2 and TAB3, activates two downstream pathways involving the IKK complex and the MAPK family.

Go back
929.0, 581.0
30.0, 30.0

p32

p32

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e65 MO000016591

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c339 : 1
stoichiometry:c100 : 1

m65*0.1

nodelay

--

true

0

false

PMID; 17275323, 16056267 TRAF6, an E3 ligase, forms a complex with Ubc13 and Uev1A to promote the synthesis of lysine 63-linked polyubiquitin chains, which in turn activate TAK1, a MAPKKK. PMID: 17275323, 16862162 Although in vitro analyses have implicated Ubc13 in the activation of NF-kappaB and MAPK, via ubiquitination of TAK1, studies on mice with a conditionally deleted Ubc13 gene in various tissues have shown that it has a dispensable role in NF-kappaB activation. PMID: 17275323, 15334086 A20, an inducible de-ubiqutination enzyme, removes ubiquitin moieties from TRAF6 to terminate TLR signaling.

Go back
1049.0, 581.0
30.0, 30.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000016574 MO000016588 MO000022125 MO000041541

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c97 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c98 : 1

m63*m1573*m1583*m6433*m19389*0.1

nodelay

--

true

0

false

PMID: 17275323 TAK1, in combination with TAB1, TAB2 and TAB3, activates two downstream pathways involving the IKK complex and the MAPK family.

Go back
1141.0, 725.0
30.0, 30.0

p34

p34

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e66 MO000000215

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m66*m186*0.1

nodelay

--

true

0

false

PMID: 17275323 The IKK complex, composed of the catalytic subunits IKKalpha and IKKbeta and a regulatory subunit IKKgamma/NEMO, catalyzes the phosphorylation of IkappaB proteins.

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1061.0, 781.0
30.0, 30.0

p35

p35

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e68

e67 e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17275323 Phosphorylated IkappaB proteins are degraded by a proteasome-dependent pathway, allowing NF-kappaB to translocate to the nucleus.

Go back
985.0, 981.0
30.0, 30.0

p36

p36

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e90

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c111 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 17275323 Phosphorylated IkappaB proteins are degraded by a proteasome-dependent pathway, allowing NF-kappaB to translocate to the nucleus.

Go back
933.0, 733.0
30.0, 30.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e72

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c119 : 1
stoichiometry:c113 : 1

m71*m74*0.1

nodelay

--

true

0

false

PMID: 17275323 TAK1 also activates the MAPK pathway, which mediates AP-1 activation.

Go back
941.0, 789.0
30.0, 30.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m219*m72*0.1

nodelay

--

true

0

false

PMID: 17275323 TAK1 also activates the MAPK pathway, which mediates AP-1 activation.

Go back
869.0, 669.0
30.0, 30.0

p39

p39

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e64

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c118 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17275323, 16862162 Although in vitro analyses have implicated Ubc13 in the activation of NF-kappaB and MAPK, via ubiquitination of TAK1, studies on mice with a conditionally deleted Ubc13 gene in various tissues have shown that it has a dispensable role in NF-kappaB activation.

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317.0, 433.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m11*m12*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.

Go back
1137.0, 997.0
30.0, 30.0

p40

p40

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016599 MO000022136

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m1593*m6443*0.1

nodelay

--

true

0

false

PMID: 17275323, 16862162 Notably, in Ubc13-deficient cells, there is a reduction in the stimulus-dependent ubiquitination of IKKgamma/NEMO, suggesting a link between Ubc13-dependent IKKgamma/NEMO ubiquitination and MAPK activation.

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441.0, 341.0
30.0, 30.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e6 MO000000041 e77

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c124 : 1

m76*m6*m82*m83*0.1

nodelay

--

true

0

false

PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal. PMID: 17275323, 16633345 It has been reported that ABIN2 (A20-binding inhibitor of NF-kappaB 2) increases the stability of Tpl2 to facilitate ERK activation.

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673.0, 1169.0
30.0, 30.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.

Go back
565.0, 1205.0
30.0, 30.0

p43

p43

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c130 : 1
stoichiometry:c129 : 1

m6*m93309*0.1

nodelay

--

true

0

false

PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.

Go back
445.0, 425.0
30.0, 30.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e6

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m78*m6*0.1

nodelay

--

true

0

false

PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.

Go back
453.0, 537.0
30.0, 30.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 MO000000022

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m6*m80*0.1

nodelay

--

true

0

false

PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.

Go back
701.0, 1197.0
30.0, 30.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17275323, 14661019 Macrophages deficient for MEKK3 show defective JNK and p38 activation and IL-6 production after LPS treatment.

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541.0, 1237.0
30.0, 30.0

p47

p47

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e6

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c141 : 1

m93248*m6*0.1

nodelay

--

true

0

false

PMID: 17275323, 14661019 Macrophages deficient for MEKK3 show defective JNK and p38 activation and IL-6 production after LPS treatment.

Go back
729.0, 1249.0
30.0, 30.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e6

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c146 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17275323 LPS-induced ROS production is implicated in facilitating the TRAF6-ASK1-p38 signaling axis.

Go back
557.0, 1285.0
30.0, 30.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 e78

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c148 : 1
stoichiometry:c147 : 1

m6*m84*0.1

nodelay

--

true

0

false

Go back
113.0, 649.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019422 MO000019397

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.

Go back
345.0, 601.0
30.0, 30.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e16

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c154 : 1

m6810*m16*0.1

nodelay

--

true

0

false

PMID: 17275323 TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway.

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341.0, 797.0
30.0, 30.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000022528

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c153 : 1

m19*m6810*0.1

nodelay

--

true

0

false

PMID: 17275323 TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway.

Go back
481.0, 417.0
30.0, 30.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e6 MO000000331 MO000044794

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c259 : 1
stoichiometry:c276 : 1
stoichiometry:c157 : 1

m6810*m6*m290229*0.1

nodelay

--

true

0

false

PMID: 17275323 TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway. PMID: 17275323 These findings suggest that TLR4 recruits TIRAP to the plasma membrane as a result of CD11b-mediated production of PIP2, which subsequently recruits MyD88 after which the signaling complex is assembled to initiate the MyD88-dependent signaling. PMID: 17275323 ST2L sequesters MyD88 and TIRAP to inhibit the recruitment of these adapters to TLR4.

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305.0, 1141.0
30.0, 30.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.

Go back
613.0, 269.0
30.0, 30.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000041125

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m6*m18998*0.1

nodelay

--

true

0

false

PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.

Go back
329.0, 1097.0
30.0, 30.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000016608 e82

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m3902*m1599*m88*0.1

nodelay

--

true

0

false

PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.

Go back
589.0, 381.0
30.0, 30.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000016608

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c168 : 1

m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.

Go back
573.0, 1385.0
30.0, 30.0

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e85

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c174 : 1
stoichiometry:c172 : 1

m977*m91*0.1

nodelay

--

true

0

false

PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.

Go back
585.0, 1321.0
30.0, 30.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e84 e133

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c173 : 1
stoichiometry:c318 : 1
stoichiometry:c176 : 1

m977*m90*0.1

nodelay

--

true

0

false

PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3. PMID: 17275323 The cleaved fragment of TRAF1 can inhibit TRIF-dependent activation of NF-kappaB and IRF3, suggesting that TRIF-induced cleavage of TRAF1 is responsible for shutdown of the TRIFdependent pathway.

Go back
641.0, 1441.0
30.0, 30.0

p59

p59

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17275323 Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.

Go back
321.0, 665.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m12*m14*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.

Go back
697.0, 1393.0
30.0, 30.0

p60

p60

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 17275323 Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.

Go back
733.0, 1357.0
30.0, 30.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 17275323 Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.

Go back
389.0, 1033.0
30.0, 30.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016608 MO000019331 MO000016963

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m1599*m3902*m1872*0.1

nodelay

--

true

0

false

PMID: 17275323 TRAF3 forms a complex with TBK1 and IKKi.

Go back
833.0, 925.0
30.0, 30.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000041125 e102

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c187 : 1
stoichiometry:c208 : 1
stoichiometry:c192 : 1

m183*m18998*m109*0.1

nodelay

--

true

0

false

PMID: 17275323, 16115877 RIP1 is reportedly polyubiquitinated and forms a complex with TRAF6 and TAK1.

Go back
1017.0, 845.0
30.0, 30.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e91 e133 e134

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c193 : 1
stoichiometry:c317 : 1
stoichiometry:c323 : 1
stoichiometry:c190 : 1

m69*m98*0.1

nodelay

--

true

0

false

PMID: 17275323 TRIF interacts with TRAF6 and RIP1, which mediate NF-kappaB activation. PMID: 17275323 The cleaved fragment of TRAF1 can inhibit TRIF-dependent activation of NF-kappaB and IRF3, suggesting that TRIF-induced cleavage of TRAF1 is responsible for shutdown of the TRIFdependent pathway. PMID: 17275323, 16052631 TRAF4 interacts with TRIF and TRAF6, and its overexpression results in inhibition of NF-kappaB activation induced by TRIF and TRAF6.

Go back
1273.0, 1033.0
30.0, 30.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 e36 MO000000212 MO000007702

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m41*m36*m183*m980*0.1

nodelay

--

true

0

false

PMID: 17275323 In pDC, a signaling complex consisting of MyD88-TRAF6-IRAK4-IRAK1-IRF7 is formed.

Go back
1273.0, 1125.0
30.0, 30.0

p66

p66

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m99*0.1

nodelay

--

true

0

false

PMID: 17275323 In this complex, IRF7 is directly phosphorylated by IRAK1, and then translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.

Go back
1117.0, 1193.0
30.0, 30.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e94 MO000000210 e93

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c226 : 1
stoichiometry:c204 : 1

m1872*m101*m181*m100*0.1

nodelay

--

true

0

false

PMID: 17275323 OPN-i, TRAF3 and IKKalpha are also involved in this complex.

Go back
705.0, 1289.0
30.0, 30.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e87

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 17275223 Phosphorylated IRF3 forms a dimer, which translocates from cytoplasm to the nucleus to induce expression of target genes including IFNbeta.

Go back
813.0, 801.0
30.0, 30.0

p69

p69

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000065

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c207 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 17275323, 16115877 RIP1 is reportedly polyubiquitinated and forms a complex with TRAF6 and TAK1.

Go back
153.0, 513.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e17

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m13*m17*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 In particular, TLR1/2 and TLR2/6 can discriminate triacyl- and diacyl-lipopeptide, respectively.

Go back
953.0, 1213.0
30.0, 30.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF7 potently activates the promoter of IFNbeta and various IFNalpha genes.

Go back
849.0, 1245.0
30.0, 30.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e103

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c211 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF7 potently activates the promoter of IFNbeta and various IFNalpha genes.

Go back
757.0, 1409.0
30.0, 30.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c213 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 17275323, 12356687, 12626561 Notably, TLR7- and TLR9-mediated type I IFN induction is elicited by the MyD88-dependent pathway, but not by the TRIF-dependent pathway.

Go back
781.0, 1429.0
30.0, 30.0

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17275323, 12356687, 12626561 Notably, TLR7- and TLR9-mediated type I IFN induction is elicited by the MyD88-dependent pathway, but not by the TRIF-dependent pathway.

Go back
929.0, 1021.0
30.0, 30.0

p74

p74

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e89

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c219 : 1
stoichiometry:c218 : 1

m980*m95*0.1

nodelay

--

true

0

false

PMID: 17275323 TRAF3 is also required for TBK1/IKKi-dependent IRF7 and IRF3 activation in TLR3 and RIG-I/Mda5-signaling.

Go back
921.0, 1361.0
30.0, 30.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e105

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c220 : 1

m112*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF7 also participates in type I IFN induction activated by the cytosolic RNA helicases RIG-I and Mda5, which recognize viral dsRNA, in conventional DC, macrophages and fibroblast cells.

Go back
721.0, 1157.0
30.0, 30.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016963

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m1872*0.1

nodelay

--

true

0

false

PMID: 17275323 TRAF3 is also necessary for the induction of anti-inflammatory cytokine IL- 10, but not pro-inflammatory cytokines, in response to ligands specific for TLR3, 4, 7 and 9.

Go back
741.0, 1205.0
30.0, 30.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e69

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c224 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 17275323, 16604075 pDC isolated from either T-bet- or OPN deficient mice have defects in the induction of type I IFN in response to TLR9-ligand, but they can produce NF-kappaB-driven IL-6 as usual.

Go back
825.0, 1437.0
30.0, 30.0

p78

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c227 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 17275323 Conventional DC derived from IRF1-deficient mice display impaired induction of IFNbeta, inducible nitric-oxide synthase and IL-12 p35, in response to a TLR9 ligand.

Go back
877.0, 1437.0
30.0, 30.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearOuterMembrane

--

e33

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c228 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 17275323 Conventional DC derived from IRF1-deficient mice display impaired induction of IFNbeta, inducible nitric-oxide synthase and IL-12 p35, in response to a TLR9 ligand.

Go back
153.0, 693.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m15*m18*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 In particular, TLR1/2 and TLR2/6 can discriminate triacyl- and diacyl-lipopeptide, respectively.

Go back
593.0, 1013.0
30.0, 30.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000007685 MO000016665

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c234 : 1
stoichiometry:c233 : 1

m1572*m970*m1639*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.

Go back
733.0, 1113.0
30.0, 30.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

G010384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c236 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 17275323 IFNgamma stimulation induces IRF1 expression.

Go back
793.0, 1221.0
30.0, 30.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e98

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c237 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.

Go back
761.0, 853.0
30.0, 30.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000007700 MO000000212 e143

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c354 : 1
stoichiometry:c240 : 1

m1572*m979*m183*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation. PMID: 17275323 As expression of the IRF4 gene is upregulated after exposure with TLR ligands, the induced IRF4 might associate with MyD88 to prevent recruitment of IRF5, thereby attenuating IRF5-dependent inflammatory responses.

Go back
833.0, 981.0
30.0, 30.0

p84

p84

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1

m106*0.1

nodelay

--

true

0

false

PMID: 17275323 IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation.

Go back
661.0, 429.0
30.0, 30.0

p85

p85

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e6 MO000041132 MO000016645

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c248 : 1
stoichiometry:c247 : 1

m6*m19005*m1629*0.1

nodelay

--

true

0

false

PMID: 17275323, 16757566 TRAM is phosphorylated at serine 16 by PKCepsilon in response to LPS.

Go back
925.0, 1509.0
30.0, 30.0

p87

p87

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e115

MO000000331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c361 : 1
stoichiometry:c250 : 1

m122*0.1

nodelay

--

true

0

false

PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.

Go back
1057.0, 1549.0
30.0, 30.0

p88

p88

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e106 MO000017291

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c256 : 1
stoichiometry:c253 : 1

m113*m2142*0.1

nodelay

--

true

0

false

PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.

Go back
37.0, 937.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019396 MO000042128

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m3963*m19942*0.1

nodelay

--

true

0

false

PMID: 17275323, 16497588 In addition, human TLR10 is thought to heterodimerize with TLR2 and TLR1, although a ligand for these heterodimers remains unknown.

Go back
689.0, 293.0
30.0, 30.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e81 MO000016573 MO000044794

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c275 : 1
stoichiometry:c262 : 1

m87*m1572*0.1

nodelay

--

true

0

false

PMID: 17275323 These findings suggest that TLR4 recruits TIRAP to the plasma membrane as a result of CD11b-mediated production of PIP2, which subsequently recruits MyD88 after which the signaling complex is assembled to initiate the MyD88-dependent signaling. PMID: 17275323 ST2L sequesters MyD88 and TIRAP to inhibit the recruitment of these adapters to TLR4.

Go back
1105.0, 1545.0
30.0, 30.0

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e116 MO000017291

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c265 : 1
stoichiometry:c264 : 1

m123*m2142*0.1

nodelay

--

true

0

false

Go back
309.0, 73.0
30.0, 30.0

p93

p93

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016653 MO000022200

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c268 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1

m1632*m6500*0.1

nodelay

--

true

0

false

PMID: 17275323 The LRR of RP105 associate with MD-1 to form a complex on the cell surface.

Go back
401.0, 73.0
30.0, 30.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e117 e119

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c273 : 1
stoichiometry:c272 : 1

m124*m126*0.1

nodelay

--

true

0

false

PMID: 17275323, 9686597 the RP105-MD-1 complex interacts with a TLR4-MD-2 complex to prevent LPS binding to TLR4-MD-2.

Go back
765.0, 341.0
30.0, 30.0

p95

p95

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066718 MO000021842 MO000000212

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c280 : 1

m41575*m6176*m183*0.1

nodelay

--

true

0

false

PMID: 17275323 SIGIRR interacts with IRAKs and TRAF6 to block TLR signaling.

Go back
297.0, 325.0
30.0, 30.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e121 MO000019394

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c282 : 1
stoichiometry:c286 : 1

m128*m3961*0.1

nodelay

--

true

0

false

PMID: 17275323 Triad3A is an E3 ligase that binds the TIR domain of TLR4 and 9, but not that of TLR2.

Go back
465.0, 1169.0
30.0, 30.0

p97

p97

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e121

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c284 : 1
stoichiometry:c285 : 1

m19828*m128*0.1

nodelay

--

true

0

false

PMID: 17275323 Triad3A is an E3 ligase that binds the TIR domain of TLR4 and 9, but not that of TLR2.

Go back
417.0, 1125.0
30.0, 30.0

p98

p98

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e122

e124 e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c289 : 1
stoichiometry:c292 : 1

m129*0.1

nodelay

--

true

0

false

PMID: 17275323 Triad3 overexpression promotes degradation of TLR4 and 9 via a proteasome-dependent pathway.

Go back
357.0, 261.0
30.0, 30.0

p99

p99

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e123

e125 e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c290 : 1
stoichiometry:c291 : 1

m130*0.1

nodelay

--

true

0

false

PMID: 17275323 Triad3 overexpression promotes degradation of TLR4 and 9 via a proteasome-dependent pathway.

Go back
174.96463602171266, 266.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.0, 401.86058570577364

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 596.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.0, 699.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1023.0, 671.6480838483988

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.0, 677.3474977942104

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1102.0, 691.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1097.0, 740.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1151.186723623442, 755.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.9869706753918, 793.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1091.0, 808.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.0, 811.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 408.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.545504308334, 867.6580753813449

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
993.3745886903887, 1011.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 752.247700587784

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.3596099683606, 760.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0, 630.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.5699763999032, 826.9796695986458

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.0, 804.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 801.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
899.0, 682.3995009355511

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
946.0, 716.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.238699645135, 470.99643811202293

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1152.0, 976.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.6921915811265, 1007.197769023179

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1014.0, 469.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
412.0, 362.1274319850065

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.19776902317903, 371.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
465.0231759794129, 243.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.0, 243.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 243.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.8483457221029, 1184.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.5536798306425, 1172.5775375331502

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
286.0, 448.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.0, 1220.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
419.0, 437.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.0809056378665, 455.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
465.8799084829226, 243.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
471.1049534754942, 243.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 544.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.3292929262616, 567.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.0, 313.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 302.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.0, 243.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
127.97935447480396, 686.9999999504394

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.3813823519705, 1227.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.7309093090201, 1228.4512399668456

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
578.9130526122185, 1255.176264577492

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.0, 243.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 243.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 243.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
686.884613462592, 1273.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.0545840621533, 1274.2289589627687

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.9320762448114, 1303.0402722944016

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
284.0, 812.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
150.5270992949498, 623.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 767.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 638.9962541943164

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 526.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.1554175279993, 775.5777087639997

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.3147951171725, 581.2394092661764

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
371.0, 454.9967431560673

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.7325416845024, 243.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 229.65718530984907

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.05591181548, 1178.3933350374516

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 873.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
143.0, 664.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 1171.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.0, 227.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 306.31388038358153

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 222.04795543439116

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 921.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.3406488985717, 963.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.9177154439756, 1134.7667475481012

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 1127.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
613.0, 226.79581666011066

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
359.0, 418.28394792412394

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 557.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 418.5320808499745

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 1375.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 1401.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.0, 1283.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
39.66410930531717, 55.56423859513632

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.0, 1345.0183750985082

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.0, 1351.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0, 1420.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 1456.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 1430.972366065959

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 669.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.7053735814004, 1388.4698886744254

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 1363.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.0, 1372.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.0, 963.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 921.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.17282667907654, 1058.5426765914951

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 1048.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.0, 859.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.3848469734717, 515.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.52380597346, 937.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.50674493453687, 686.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.0, 875.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 774.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.0, 928.2304815589116

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.0, 871.5777087639997

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1083.679177046512, 119.66637969758551

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.0, 359.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 515.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 1037.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1244.1601724872446, 1060.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1238.0, 1122.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.57916207469313, 279.56052772793686

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0522769188681, 464.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.7710985682477, 1154.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.0, 1145.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.0, 1230.7336418228922

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1125.0, 1230.9872147658687

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.0, 1222.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 1325.4

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.0, 1291.2244646123283

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.0, 831.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.2164574740316, 886.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.8995250553337, 1231.2639240088533

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
168.0, 483.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 1228.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.5894663844041, 1265.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.9055512611654, 1238.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
787.0, 1386.5347985803924

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.0, 1384.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
360.0, 1466.994171609234

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
811.0, 1389.3643173537448

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.0, 1036.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.0, 1046.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 1036.2369330563172

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
183.0, 514.7354436625493

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.9917483216824, 1374.3632612873491

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.8264050749225, 1168.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.0, 1148.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
751.0, 1172.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.0819478035057, 1228.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.7519343451731, 1165.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1154.9924492668404, 1206.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0, 1432.4698886744254

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 1434.3148177390106

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.5136675681298, 1351.7582915276205

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
191.0, 708.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.5104059540729, 1364.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.4974849975681, 399.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 963.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 1033.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
86.0, 1007.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
86.0, 1009.0

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.0, 1130.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.6906911759853, 1251.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.8132665336364, 1211.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
734.0, 399.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
168.0, 731.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 883.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.0, 812.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.3530054571548, 515.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
794.0, 972.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.0, 997.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.0, 243.0

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
667.0, 388.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.2680368629482, 459.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 444.0

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
181.0, 723.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 1539.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.0, 1564.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1041.9711576880163, 1526.2679814327162

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
997.923410283849, 1520.0

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1079.5298221281348, 1519.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
501.90248134891004, 55.974827868583986

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
51.89203316677731, 347.6007338088598

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 210.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.9373322778883, 330.4412417706506

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.3124295713869, 224.73817120529208

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1131.690821893136, 1520.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1123.0, 1451.8620948547216

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 1519.0

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
307.0, 110.83086959900544

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.5269572728178, 110.85292311734865

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 952.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 103.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 110.85353254141936

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 103.0

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0, 110.43277985925367

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.58214756743615, 109.77994910183163

c274

c274

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
713.9425717247145, 284.0

c275

c275

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
514.2448872193527, 279.0

c276

c276

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
802.0231645833151, 367.8308170454446

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.9418702562697, 342.0

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.1847449441826, 378.33876008876865

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
67.0, 956.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.5909734841225, 371.0

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
318.13763205856674, 362.7091198707886

c281

c281

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 248.0

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.0, 1204.840171189057

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 739.0

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.70814327703954, 1187.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
314.0, 290.9639637807516

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
338.0, 265.0

c287

c287

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 1163.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
417.17160007563183, 1113.8262546692156

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
100.01482073526778, 618.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.8479626207359, 291.0

c290

c290

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.0, 291.0

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.2899647828829, 746.9947432994867

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.4062548214393, 399.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0, 533.6643638388299

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.8462884367482, 547.0

c295

c295

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.0, 744.2033241302223

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
530.8662560398757, 748.4567140814585

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.9922778767137, 759.0

c298

c298

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.0, 719.4417494565181

c299

c299

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.57146299089314, 238.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
122.64353983444505, 911.3614188106416

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.0, 750.1049392463369

c300

c300

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
474.0, 727.0

c301

c301

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.29297309669477, 808.0

c302

c302

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.9876828256433, 838.0

c303

c303

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 855.0

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 930.0

c305

c305

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 859.0

c306

c306

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.1927794053147, 955.0

c307

c307

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.0, 989.0

c308

c308

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.0, 997.4437601569801

c309

c309

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
115.0, 904.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.0, 857.0

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.9042304960182, 786.0

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 841.1049392463369

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0809056378665, 851.0

c313

c313

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 888.0

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.96891354715143, 858.7045685758152

c315

c315

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.991972499923, 852.0

c316

c316

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
751.0, 861.3891230293839

c317

c317

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
606.162824615894, 903.0

c318

c318

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
771.0, 503.0

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
178.33656045002587, 1055.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.4698886744255, 509.0

c320

c320

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 550.542576049781

c321

c321

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 551.0

c322

c322

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
798.0, 626.0

c323

c323

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1098.3025460151594, 1238.266928480466

c324

c324

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1090.0, 1243.0

c325

c325

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.9195959492893, 1230.0

c326

c326

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 1336.0

c327

c327

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
827.0, 1336.0

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 1336.0

c329

c329

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
156.0, 1036.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 1307.8599434057003

c330

c330

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 1358.033305236507

c331

c331

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
743.0, 1078.0

c332

c332

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.0, 1163.0

c333

c333

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.196208331825, 406.91006230233825

c334

c334

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.229656050255, 1020.0

c335

c335

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
907.0, 1090.0

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 1005.9782444208057

c337

c337

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.0, 492.0

c338

c338

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
962.5658102911036, 496.0

c339

c339

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
171.0, 1092.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 1378.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.0, 1528.0

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 1447.0

c342

c342

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.8102651883261, 1489.0

c343

c343

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.0, 1528.0

c344

c344

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.9025708613195, 1549.983547857098

c345

c345

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.0, 1577.8724307086002

c346

c346

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 1574.0

c347

c347

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.0, 1575.2164574740316

c348

c348

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 1104.0

c349

c349

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
161.0, 1151.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 243.0

c350

c350

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
741.0, 342.2636750760036

c351

c351

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.3104923889621, 306.0

c352

c352

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.5832391214975, 335.0

c353

c353

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0, 732.0

c354

c354

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
581.7504238850622, 218.0

c355

c355

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
490.4708540135693, 720.8611781328564

c356

c356

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
275.0, 583.0

c357

c357

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
375.0, 704.687474113529

c358

c358

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0856580228888, 715.0

c359

c359

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
186.00462147221435, 1148.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.7615473891659, 1539.0

c360

c360

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.3033886328969, 1441.0

c361

c361

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
922.1134997064896, 1398.0

c362

c362

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
906.0, 1527.0

c363

c363

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.2888620248546, 1555.0

c364

c364

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.0, 1188.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.6721416644712, 1290.2667691281392

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
181.0, 1264.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
167.0, 213.9856296404518

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
291.0, 1269.8402036314317

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
143.0, 1453.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.53468595972123, 1374.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 1460.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.08543002348836, 1377.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
127.0, 1524.9792745494692

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 1498.5393108639387

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.8988125883308, 1428.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 1591.773201126973

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
307.0, 1526.2328103284767

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
206.0, 102.90837272928586

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.108938905754, 1430.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 1615.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 1490.8859377304238

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.27532473256707, 1320.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 1400.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
263.0, 1371.824491210522

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.80573001674856, 1311.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 1333.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
251.0, 1329.2579303520877

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.0, 100.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.0, 122.99385560585235

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.7323794809093, 122.07596943255739

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.0, 115.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0100342373913, 250.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 331.8771118950373

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.5689290811055, 722.8446454055273

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
849.0, 253.74449952347098

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.8248294593392, 254.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.0, 504.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.0, 218.72513707898776

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.7415535635198, 254.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 106.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.0, 283.5618009266197

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1119.0, 208.1005417122738

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
839.6477649329415, 254.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.0, 309.06412018160347

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1155.0, 300.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.5097200609586, 254.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.0, 381.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1135.0, 433.2665186418611

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1022.8587085313798, 289.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.0, 254.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
152.82081001928753, 359.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
914.0, 310.9889426346601

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 250.15541752799933

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.0, 221.57745276819264

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.2665186418611, 243.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.0, 524.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.7789890173317, 222.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 460.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0, 261.3788877180506

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
909.4990262892414, 477.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 482.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
130.77994910183162, 447.9999938233041

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.8623479330104, 484.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
982.0, 524.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.0, 524.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.9711254108329, 551.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 596.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.1554175279994, 607.5777087639997

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1083.558496167435, 616.7535311206782

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1085.9102312071875, 559.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.951069877389, 592.8834522085988

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.9510698773889, 592.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back