1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17275324.csml convertedTime:2009.07.01.11:00

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Innate immune sensing of pathogens and danger signals by cell surface Toll-likereceptors.
Authors Miyake K.
Affiliation Division of Infectious Genetics, The Institute of Medical Science, TheUniversity of Tokyo, Japan. kmiyake@ims.u-tokyo.ac.jp
Abstract The Toll family of receptors consists of cell surface TLRs (TLR4/MD-2, TLR1,TLR2, and TLR6) and intracellular TLRs (TLR3, TLR7, TLR8, and TLR9). Cellsurface TLRs sense microbial membranes such as lipopolysaccharide orlipopeptides. Recognition by TLRs is the frontline where pathogens and a hosttry to take the control of immune responses. Bacteria can modulate the structureof a TLR ligand lipid A to subvert host responses. Cell surface TLRs also senseendogenous ligands which are released in tissue damages as danger signals andinduce inflammation in infectious and non-infectious condition. The availabilityof endogenous ligands and the amount of cell surface TLRs are both tightlylimited to keep TLR responses sufficient for containment of pathogens withoutdetrimental responses to the host.
PMID 17275324
Model Abstract

Entity

G010228:IFN-beta G010329:TNF-alpha G010514:iNOS G010657:IL-12 p40 G010693:Tlr4 MO000000058:NF-kappaB MO000000289:TNF-alpha MO000007694:IRF-3 MO000016573:MyD88 MO000016653:RP105 MO000016660:IFNbeta MO000016882:LPS MO000017265:IL-12 MO000018132:CD14 MO000019394:TLR4 MO000019420:LBP MO000020119:Hsp60 MO000021614:Hsp70 MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022131:MD-2 MO000022200:MD-1 MO000022528:TIRAP MO000041125:TRIF MO000041132:TRAM MO000041456:IRF-3{p} MO000042012:TLR9 e1: e10:TLR4{Gly} e11:LPS:LBP:CD14:TLR4{oligomer}:MD2 e12:LPS:MD-2 e13:LPS:LBP:CD14:TLR4{oligomer}:MD2:MyD88:TIRAP e14:NF-kappaB{active} e15:pro-inflammatory cytokines e16:Pro-inflammtory cytokies e17:LPS:LBP:CD14:TLR4{oligomer}:MD2:TRIF:TRAM e18:IRF-3{p}:IRF-3{p} e19:TLR2:TLR6 e2: e20:triacylated lipopeptide e21:Triacylated lipopeptide:TLR2:TLR6 e22:TLR2:TLR1 e23:CD36 e24:TLR2:TLR1:CD14 e25:TLR2:TLR1:CD36 e26:Diacylated lipopeptide e27:TLR2:TLR1:CD14:Di acylated lipopeptide e28:TLR2:TLR1:CD36:Di acylated lipopeptide e29:Lipoteichoic acid e3: e30:TLR2:TLR1:CD14:Lipoteichoic acid e31:TLR2:TLR1:CD36:Lipoteichoic acid e32: e33: e34: e35:A/D type CpG e36:A/D type CpG:TLR9 e37: e38: e39: e4: e40:TLR9 e41:B/K type CpG e42:B/K type CpG: TLR9 e43:RP105:MD-1 e44:RP105:MD-1:TLR4:MD-2 e45:NO e46: e47: e48: e49: e5:TLR4:MD2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:LBP:CD14:TLR4:MD2 e60: e61: e62: e63: e64: e65:gp96 e66:pr0-inflammtory cytokines e67:Co-stimulatory molecules e68:TLR4 e69:TLR4:gp96 e7: e70:Biglycan e71:TLR4:MD-2:Biglycan e72:TLR2:TLR6:Biglycan e73:p38 e74:p38{active} e75:ERK e76:ERK{active} e77:MIP-2 e78:CD14:TLR4:MD-2 e79:CD14:TLR4:MD-2:Biglycan e8: e80:Cellular fibronectin e81:MMP-9 e83:SP-A e84:IL-10 e85:IL-10 e86:HMGB1 e87:TLR4:MD-2:HMGB1 e88:HMGB1:TLR2:TLR6 e89:OxLDL e9: e90:Actin e91:Actin polymer e92:mDF2beta e93:TLR4;MD-2:mDFbeta

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p6 p7 p8 p9
Model Detail
753.0, 1105.0
29.0, 29.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p12

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
720.0, 1252.0
32.0, 32.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p43 p44 p45

p25 p51

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
737.0, 1329.0
30.5, 30.5

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p26

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
342.0, 1338.0
36.0, 36.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
450.0, 1158.0
28.0, 28.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
491.0, 611.0
26.0, 26.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p36 p37 p50

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1240.0, 1152.0
23.0, 23.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25 p51

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
756.0, 420.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
418.0, 290.0
27.0, 27.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1158.0, 794.0
20.0, 20.0

RP105

--

MO000016653

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1632

10

false

infinite

0

unit false false false
InterProIPR000483
TRANSPATHMO000016653

--

Go back
1256.0, 976.0
23.0, 23.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
229.0, 93.0
22.0, 22.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p5

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
35.0, 1227.0
26.0, 26.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
115.0, 251.0
25.0, 25.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p14

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
113.0, 509.0
21.0, 21.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p22 p46

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
72.0, 92.0
24.0, 24.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
683.0, 919.0
26.0, 26.0

Hsp60

--

MO000020119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26

true true true true

csml-variable:Double

m4645

10

false

infinite

0

unit false false false
InterProIPR002423
TRANSPATHMO000020119

--

Go back
395.0, 891.0
26.0, 26.0

Hsp70

--

MO000021614

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m5956

10

false

infinite

0

unit false false false
InterProIPR001023
TRANSPATHMO000021614

--

Go back
96.0, 164.0
24.0, 24.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
275.0, 231.0
25.0, 25.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3 p49

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
115.0, 323.0
25.0, 25.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p22

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1152.0, 852.0
24.0, 24.0

MD-1

--

MO000022200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m6500

10

false

infinite

0

unit false false false

--

Go back
245.0, 309.0
21.0, 21.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
650.0, 282.0
19.0, 19.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
753.0, 325.0
21.0, 21.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
849.0, 549.0
22.0, 22.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p11

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
288.0, 560.0
23.5, 23.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
85.50834309444289, 215.81908564308023
1124.7428448081473, 1400.9572813466525

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
121.0, 573.0
21.0, 21.0

TLR4{Gly}

--

e10

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m10

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
560.0, 205.0
23.11764705882353, 38.52941176470589

LPS:LBP:CD14:TLR4{oligomer}:MD2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p6 p9 p25 p26

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
120.5, 382.0
22.879186802199634, 28.015330778203634

LPS:MD-2

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
120.0, 449.0
23.11764705882353, 38.52941176470589

LPS:LBP:CD14:TLR4{oligomer}:MD2:MyD88:TIRAP

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
579.0, 687.0
26.0, 26.0

NF-kappaB{active}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p36 p37 p50

p8 p41 p44 p51 p52

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
361.0, 1218.0
53.615916955017305, 28.59515570934256

pro-inflammatory cytokines

--

e15

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p8 p28

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
32.0, 935.0
15.055191768007482, 34.74275023386341

Pro-inflammtory cytokies

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

p8

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
848.0, 233.0
23.11764705882353, 38.52941176470589

LPS:LBP:CD14:TLR4{oligomer}:MD2:TRIF:TRAM

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
850.5, 764.0
19.05782369605066, 23.3361106482253

IRF-3{p}:IRF-3{p}

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
949.5, 243.0
20.748041993001166, 25.405765705715716

TLR2:TLR6

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p13 p33 p54

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
85.50834309444289, 215.81908564308023
1124.7428448081473, 1400.9572813466525

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
863.0, 174.0
49.85702270815812, 28.252312867956267

triacylated lipopeptide

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1068.5, 228.0
23.555698293264822, 32.86841622316022

Triacylated lipopeptide:TLR2:TLR6

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1161.5, 327.0
20.748041993001166, 25.405765705715716

TLR2:TLR1

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p14 p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1155.5, 434.0
17.044274501911854, 27.639364057154353

CD36

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1151.5, 371.0
24.59735731326849, 34.321893925490905

TLR2:TLR1:CD14

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p16 p18

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1151.5, 491.0
24.59735731326849, 34.321893925490905

TLR2:TLR1:CD36

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p17 p19

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1310.0, 324.0
43.624894869638354, 24.72077375946174

Diacylated lipopeptide

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p16 p17

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1148.0, 552.0
24.26470588235294, 40.44117647058824

TLR2:TLR1:CD14:Di acylated lipopeptide

--

e27

cso30:c:Complex

cso30:i:CC_Extracellular

--

p16

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1148.0, 604.0
24.26470588235294, 40.44117647058824

TLR2:TLR1:CD36:Di acylated lipopeptide

--

e28

cso30:c:Complex

cso30:i:CC_Extracellular

--

p17

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1265.0, 563.0
45.64339781328847, 25.8645920941968

Lipoteichoic acid

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p18 p19

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
108.00319999060582, 235.11601789303415
1079.7531310158217, 1362.363416846745

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1152.0, 668.0
24.26470588235294, 40.44117647058824

TLR2:TLR1:CD14:Lipoteichoic acid

--

e30

cso30:c:Complex

cso30:i:CC_Extracellular

--

p18

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1152.0, 728.0
24.26470588235294, 40.44117647058824

TLR2:TLR1:CD36:Lipoteichoic acid

--

e31

cso30:c:Complex

cso30:i:CC_Extracellular

--

p19

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
269.0, 559.3664877780517
91.61765877154707, 152.95490489826085

--

e32

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false true false

--

Go back
269.0, 559.3664877780517
91.61765877154707, 152.95490489826085

--

e33

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false true false

--

Go back
269.0, 559.3664877780517
91.61765877154707, 152.95490489826085

--

e34

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false true false

--

Go back
6.0, 521.5
60.0, 13.0

A/D type CpG

--

e35

cso30:c:Dna

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p20

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
265.5, 615.0
21.32821749616312, 41.28042096031572

A/D type CpG:TLR9

--

e36

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p20

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
265.0, 752.5
110.36009313172265, 103.33342053532088

--

e37

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Lysosome

--

--

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false true false

--

Go back
265.0, 752.5
110.36009313172265, 103.33342053532088

--

e38

cso30:c:EntityBiologicalCompartment

cso30:i:CC_LysosomalLumen

--

--

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false true false

--

Go back
265.0, 752.5
110.36009313172265, 103.33342053532088

--

e39

cso30:c:EntityBiologicalCompartment

cso30:i:CC_LysosomalMembrane

--

--

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false true false

--

Go back
149.6186852485075, 268.88564933045336
996.5221605000183, 1294.8241539719065

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
300.0, 748.0
23.5, 23.5

TLR9

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
2.0, 737.5
60.0, 13.0

B/K type CpG

--

e41

cso30:c:Dna

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p21

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
269.5, 812.0
21.15829861872396, 40.951545713659286

B/K type CpG: TLR9

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1151.5, 905.0
24.822529578403596, 30.39493417763706

RP105:MD-1

--

e43

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p23

p24

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1157.0, 962.0
21.970588235294123, 36.61764705882354

RP105:MD-1:TLR4:MD-2

--

e44

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p24

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1035.0, 1236.0
42.74179983179142, 24.220353238015143

NO

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

p26

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
509.1381528463296, 759.6596483416541
228.82528870657714, 64.40446867569229

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false true false

--

Go back
508.00160339911145, 758.5230988944362
231.0983876010134, 66.67756757012849

--

e47

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false true false

--

Go back
509.89585247780826, 760.4173479731331
227.3098894436197, 62.88906941273481

--

e48

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false true false

--

Go back
505.72850450467524, 756.25
235.6445853898858, 71.22376535900096

--

e49

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false true false

--

Go back
371.5, 233.0
24.357107148808534, 29.82502916180637

TLR4:MD2

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p3 p24 p32 p49 p53 p55 p56

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
258.589972562027, 1025.749461962888
611.6564284656395, 475.8469142850631

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
324.65342293634205, 1037.0263420588412
357.6538520264637, 461.1904384857287

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
266.56314760720295, 1032.1006014759328
595.710078375288, 463.1446352589729

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
267.7021726136568, 1033.0776998625556
593.4320283623804, 461.1904384857287

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
258.589972562027, 1025.749461962888
611.6564284656395, 475.8469142850631

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
258.589972562027, 1025.749461962888
611.6564284656395, 475.8469142850631

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
267.7021726136568, 1033.0776998625556
593.4320283623804, 461.1904384857287

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
705.0877750918779, 1221.1691392873483
38.21293290179514, 29.674967711220827

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
604.8535745239524, 1357.962913414473
108.20737561310195, 84.03046124951838

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
258.589972562027, 1025.749461962888
611.6564284656395, 475.8469142850631

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
480.0, 217.0
23.11764705882353, 38.52941176470589

LPS:LBP:CD14:TLR4:MD2

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3 p49

p4 p48 p50

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
402.75395119754205, 1237.2118987157487
19.370260354791736, 8.000554419609255

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
402.1071233751935, 1213.3523521943719
66.29985179074865, 102.37410077195584

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
429.9207197361915, 1279.9371331842626
10.349245157580269, 8.877970798651997

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
505.72850450467524, 756.25
235.6445853898858, 71.22376535900096

--

e63

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false true false

--

Go back
505.72850450467524, 756.25
235.6445853898858, 71.22376535900096

--

e64

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false true false

--

Go back
574.0, 807.5
27.108070034212123, 16.71664318776414

gp96

--

e65

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p28 p29 p30 p31

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
56.5, 1039.0
15.778426242704768, 25.586637150332056

pr0-inflammtory cytokines

--

e66

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p28

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
545.0, 1319.0
46.92041522491349, 25.024221453287197

Co-stimulatory molecules

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p29 p57

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
541.0, 749.0
21.0, 21.0

TLR4

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
703.5, 759.0
17.90944968208726, 34.66345099758824

TLR4:gp96

--

e69

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p30

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
76.28582354415494, 241.4566484933777
1103.022318618733, 1340.7606981159522

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
34.0, 699.5
27.615214328838807, 17.029382169450596

Biglycan

--

e70

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p32 p33 p46 p47

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
115.5, 810.0
25.907322444485224, 36.14975224811892

TLR4:MD-2:Biglycan

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p34 p36 p38

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
114.5, 886.0
25.08662139842173, 35.004587997797756

TLR2:TLR6:Biglycan

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

p35 p37 p39

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
339.0, 434.5
25.599999999999998, 19.2

p38

--

e73

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p34 p35

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
543.0, 530.5
25.599999999999998, 19.2

p38{active}

--

e74

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p34 p35

p40 p45

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
601.0, 547.0
14.49579045837231, 33.45182413470533

ERK

--

e75

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p38 p39

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
661.0, 667.0
14.49579045837231, 33.45182413470533

ERK{active}

--

e76

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p38 p39

p42 p43

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
489.0, 1210.0
53.667820069204154, 28.622837370242216

MIP-2

--

e77

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40 p41 p42

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
116.5, 664.0
22.829693521747103, 31.85538630941457

CD14:TLR4:MD-2

--

e78

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p47

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
130.0, 998.0
20.558823529411768, 34.264705882352956

CD14:TLR4:MD-2:Biglycan

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
131.22648499741146, 253.11977922773133
1058.1424536116124, 1318.00116082718

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
580.5, 107.0
15.510364258402095, 25.15194204065204

Cellular fibronectin

--

e80

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
466.0, 1280.0
39.65397923875433, 21.148788927335644

MMP-9

--

e81

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p48

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
388.0, 71.5
23.04, 17.279999999999998

SP-A

--

e83

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p49

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
618.0, 1306.0
52.05882352941177, 27.76470588235294

IL-10

--

e84

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p52

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1233.0, 1339.5
22.72, 17.039999999999996

IL-10

--

e85

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p52

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
712.5, 411.0
15.435902596095794, 25.031193399074258

HMGB1

--

e86

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p53 p54

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
727.5, 247.0
24.9051202055423, 34.751330519361346

TLR4:MD-2:HMGB1

--

e87

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p53

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1154.5, 213.0
26.814828408882363, 37.41603964030097

HMGB1:TLR2:TLR6

--

e88

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p54

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
672.0, 151.0
15.103835360149674, 34.85500467726848

OxLDL

--

e89

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p55

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
99.22544625422913, 230.73048592691896
1025.8209221685463, 1266.768329899306

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
987.5, 395.0
16.508150533306495, 26.769973837794314

Actin

--

e90

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p55

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
929.0, 469.0
30.0, 30.0

Actin polymer

--

e91

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p55

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
730.0, 537.5
27.373717045683225, 16.88045884483799

mDF2beta

--

e92

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p56

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1154.5, 277.34373279500824
26.270324830244082, 36.65626720499175

TLR4;MD-2:mDFbeta

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p56

p57

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
129.0, 93.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019420 MO000016882

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3985*m155666*0.1

nodelay

--

true

0

false

PMID: 17275324 LBP is thought to be a shuttle protein catalyzing LPS transfer from the outer membrane of Gram-negative bacteria to CD14, another LPS binding molecule.

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813.0, 473.0
21.0, 21.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e17 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m18*m977*0.1

nodelay

--

true

0

false

PMID: 17275324 A second set of adaptor molecules, TIR domain-containing adapter inducing interferon-beta (TRIF)/TIR domain-containing adapter molecule-1 (TICAM-1) and TRIF-related adapter molecule (TRAM)/TIR domain-containing adapter molecule- 2 (TICAM-2), are required for LPS-induced phosphorylation and dimerization of the transcription factor IRF-3, leading to interferon-beta (IFN-beta) production

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850.0, 658.0
19.0, 19.0

p11

p11

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17275324 A second set of adaptor molecules, TIR domain-containing adapter inducing interferon-beta (TRIF)/TIR domain-containing adapter molecule-1 (TICAM-1) and TRIF-related adapter molecule (TRAM)/TIR domain-containing adapter molecule- 2 (TICAM-2), are required for LPS-induced phosphorylation and dimerization of the transcription factor IRF-3, leading to interferon-beta (IFN-beta) production PMID: 17275324 Figure 1

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804.0, 976.0
23.0, 23.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e18

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m93217*m19*0.1

nodelay

--

true

0

false

PMID: 17275324 A second set of adaptor molecules, TIR domain-containing adapter inducing interferon-beta (TRIF)/TIR domain-containing adapter molecule-1 (TICAM-1) and TRIF-related adapter molecule (TRAM)/TIR domain-containing adapter molecule- 2 (TICAM-2), are required for LPS-induced phosphorylation and dimerization of the transcription factor IRF-3, leading to interferon-beta (IFN-beta) production PMID: 17275324 Figure 1

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950.0, 178.0
20.0, 20.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m20*m21*0.1

nodelay

--

true

0

false

PMID: 17275324 Tricacylated lipopeptide is recognized by TLR1/TLR2, whereas diacylated lipopeptide is sensed by TLR2/TLR6.

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949.0, 321.0
22.0, 22.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000018132

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m23*m2828*0.1

nodelay

--

true

0

false

PMID: 17275324,15895089,15690042 CD14 is required for diacylated lipopeptides and lipoteichoic acid whereas forward genetics revealed thatCD36 is another accessory molecule for TLR2 in its response to diacylated lipopeptide and lipoteichoic acid

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1281.0, 433.0
22.0, 22.0

p14

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m23*m24*0.1

nodelay

--

true

0

false

PMID: 17275324,15895089,15690042 CD14 is required for diacylated lipopeptides and lipoteichoic acid whereas forward genetics revealed thatCD36 is another accessory molecule for TLR2 in its response to diacylated lipopeptide and lipoteichoic acid

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1253.0, 377.0
22.0, 22.0

p14

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m25*m27*0.1

nodelay

--

true

0

false

PMID: 17275324,15895089,15690042 CD14 is required for diacylated lipopeptides and lipoteichoic acid whereas forward genetics revealed thatCD36 is another accessory molecule for TLR2 in its response to diacylated lipopeptide and lipoteichoic acid

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1333.0, 497.0
22.0, 22.0

p14

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m26*m27*0.1

nodelay

--

true

0

false

PMID: 17275324,15895089,15690042 CD14 is required for diacylated lipopeptides and lipoteichoic acid whereas forward genetics revealed thatCD36 is another accessory molecule for TLR2 in its response to diacylated lipopeptide and lipoteichoic acid

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1265.0, 473.0
22.0, 22.0

p14

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m25*m30*0.1

nodelay

--

true

0

false

PMID: 17275324,15895089,15690042 CD14 is required for diacylated lipopeptides and lipoteichoic acid whereas forward genetics revealed thatCD36 is another accessory molecule for TLR2 in its response to diacylated lipopeptide and lipoteichoic acid

Go back
1289.0, 649.0
22.0, 22.0

p14

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m26*m30*0.1

nodelay

--

true

0

false

PMID: 17275324,15895089,15690042 CD14 is required for diacylated lipopeptides and lipoteichoic acid whereas forward genetics revealed thatCD36 is another accessory molecule for TLR2 in its response to diacylated lipopeptide and lipoteichoic acid

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229.0, 165.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 17275324 LBP is thought to be a shuttle protein catalyzing LPS transfer from the outer membrane of Gram-negative bacteria to CD14, another LPS binding molecule.

Go back
48.0, 620.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e35 MO000042012

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m36*m19828*0.1

nodelay

--

true

0

false

PMID: 17275324 A/D-type CpG is retained for long periods in the endosomal vesicles of plasmacytoid dendritic cells, together with the complex consisting of downstream signaling molecules, whereas the B/K-type CpG. is recognized by TLR9 in the lysosome.

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188.0, 768.0
23.0, 23.0

p20

p21

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e41 e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m42*m41*0.1

nodelay

--

true

0

false

PMID: 17275324 A/D-type CpG is retained for long periods in the endosomal vesicles of plasmacytoid dendritic cells, together with the complex consisting of downstream signaling molecules, whereas the B/K-type CpG. is recognized by TLR9 in the lysosome.

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221.0, 445.0
21.0, 21.0

p22

p22

cso30:i:ME_Glycosylation

cso30:i:CC_Cytoplasm

--

MO000019394 MO000022131

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m3961*m6438*0.1

nodelay

--

true

0

false

PMID: 17275324 The LPS coreceptor MD-2 was also shown to facilitate glycosylation and cell surface expression of TLR4.

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1238.0, 830.0
19.0, 19.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016653 MO000022200

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m1632*m6500*0.1

nodelay

--

true

0

false

PMID: 17275324,7897216 Radioprotective 105 (RP105) is most similar to TLR4 in extracellular leucine-rich repeats than other members of the Toll family, and forms a complex with MD-1, cloning of which led to the cloning of MD-2 as a molecule similar to MD-1

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1050.0, 910.0
19.0, 19.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e43 e5

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m44*m5*0.1

nodelay

--

true

0

false

PMID: 17275324,15852007 A molecular mechanism by which RP105/MD-1 contribute to B cell responses to TLR4/MD-2 and TLR2 ligands was suggested by a recent report demonstrating that RP105/MD-1 is associated with TLR4/MD-2

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930.0, 1142.0
19.0, 19.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

MO000020119 G010329 e11

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c79 : 1
stoichiometry:c75 : 1

m4645*m93309*m11*0.1

nodelay

--

true

0

false

PMID: 17275324,10623794,11402040 HSP60-dependent induction of TNF-alpha and NO in macrophages was dependent on TLR4 signaling

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906.0, 1238.0
19.0, 19.0

p25

p26

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

MO000020119 G010514 e11

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c80 : 1
stoichiometry:c78 : 1

m4645*m93479*m11*0.1

nodelay

--

true

0

false

PMID: 17275324,10623794,11402040 HSP60-dependent induction of TNF-alpha and NO in macrophages was dependent on TLR4 signaling

Go back
198.0, 1226.0
19.0, 19.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

MO000021614 G010657

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m5956*m93589*0.1

nodelay

--

true

0

false

PMID: 17275324,11842086 HSP70 induces interleukin-12 (IL-12) production in macrophages

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265.0, 1041.0
21.0, 21.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e65 e15

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m66*m16*0.1

nodelay

--

true

0

false

PMID: 17275324,11912201 An ER chaperone gp96 induces production of proinflammatory cytokines and upregulation of co-stimulatory molecules in bone marrow DCs from wild type mice, whereas DCs from TLR4 mutant or TLR4/TLR2 double mutant mice failed to respond to gp96

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581.0, 1073.0
21.0, 21.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 17275324,11912201 An ER chaperone gp96 induces production of proinflammatory cytokines and upregulation of co-stimulatory molecules in bone marrow DCs from wild type mice, whereas DCs from TLR4 mutant or TLR4/TLR2 double mutant mice failed to respond to gp96

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373.0, 145.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021929 e5 e80

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c136 : 1
stoichiometry:c9 : 1

m6255*m5*m81*0.1

nodelay

--

true

0

false

PMID: 17275324 CD14 has a role in loading LPS to the receptor complex consisting of TLR4 and MD-2. PMID: 17275324,11150311 Recombinant EDA, but not other recombinant fibronectin domains, induces expression of a matrix methalloproteinase MMP-9 in human macrophages by stimulating TLR4

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602.0, 730.0
19.0, 19.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e68 e65

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m69*m66*0.1

nodelay

--

true

0

false

PMID: 17275324 An ER chaperon gp96 is associated with TLR4 in ER and required for cell surface expression of TLR4

Go back
417.0, 989.0
21.0, 21.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010693 e65

MO000019394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m93614*m66*0.1

nodelay

--

true

0

false

PMID: 17275324 An ER chaperon gp96 is associated with TLR4 in ER and required for cell surface expression of TLR4

Go back
181.0, 697.0
22.0, 22.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e70 e5

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m71*m5*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
297.0, 897.0
22.0, 22.0

p32

p33

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e70 e19

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m71*m20*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
421.0, 485.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m72*m74*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
417.0, 649.0
21.0, 21.0

p34

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e72 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m73*m74*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
409.0, 737.0
21.0, 21.0

p34

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m72*m14*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
425.0, 809.0
21.0, 21.0

p34

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e72 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m73*m14*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
369.0, 609.0
21.0, 21.0

p34

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e71 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m72*m76*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
437.0, 849.0
21.0, 21.0

p34

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e72 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m73*m76*0.1

nodelay

--

true

0

false

PMID: 17275324 Biglycan, a small leucine-rich proteoglycan in ECM component, acts on macrophages as an endogenous ligand of TLR4 and TLR2, leading to rapid activation of p38, ERK, and NF-KappaB and thereby stimulating the expression of TNF-alpha and macrophage inflammatory protein-2 (MIP-2).

Go back
481.0, 145.0
21.0, 21.0

p4

p4

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17275324 LPS is similar to a cytokine in that it interacts with a receptor TLR4/MD-2, and induces oligomerization of TLR4, leading to activation of downstream signaling pathways by recruiting downstream adaptor molecules

Go back
541.0, 1089.0
21.0, 21.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m75*0.1

nodelay

--

true

0

false

--

Go back
637.0, 1073.0
21.0, 21.0

p40

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m15*0.1

nodelay

--

true

0

false

--

Go back
505.0, 1065.0
21.0, 21.0

p40

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m77*0.1

nodelay

--

true

0

false

--

Go back
589.0, 1229.0
21.0, 21.0

p40

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e76

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m77*0.1

nodelay

--

true

0

false

--

Go back
705.0, 1125.0
21.0, 21.0

p40

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m15*0.1

nodelay

--

true

0

false

--

Go back
481.0, 1109.0
21.0, 21.0

p40

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m75*0.1

nodelay

--

true

0

false

--

Go back
197.0, 533.0
21.0, 21.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019394 e70

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m3961*m71*0.1

nodelay

--

true

0

false

--

Go back
229.0, 941.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e70 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m71*m79*0.1

nodelay

--

true

0

false

PMID: 17275324 Moreover, biglycan was shown to be physically associated with CD14/TLR4/MD-2.

Go back
373.0, 1121.0
23.0, 23.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17275324,11150311 Recombinant EDA, but not other recombinant fibronectin domains, induces expression of a matrix methalloproteinase MMP-9 in human macrophages by stimulating TLR4

Go back
313.0, 133.0
21.0, 21.0

p3

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e83 MO000021929 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m84*m6255*m5*0.1

nodelay

--

true

0

false

PMID: 17275324 CD14 has a role in loading LPS to the receptor complex consisting of TLR4 and MD-2. PMID: 17275324,12055204 SP-A induces NF-KappaB activation and cytokine production such as TNF-alpha and IL-10 in macrophages by stimulating TLR4

Go back
176.0, 348.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000022131

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m155666*m6438*0.1

nodelay

--

true

0

false

PMID: 17275324,15557191,15010525,11521076 Direct interaction between LPS and purified MD-2 without TLR4 was also reported whereas the direct interaction between TLR4 and LPS has not been demonstrated.

Go back
546.0, 458.0
22.0, 22.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e6 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m6*m14*0.1

nodelay

--

true

0

false

PMID: 17275324,12055204 SP-A induces NF-KappaB activation and cytokine production such as TNF-alpha and IL-10 in macrophages by stimulating TLR4

Go back
932.0, 1196.0
23.0, 23.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e14 G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m15*m93309*0.1

nodelay

--

true

0

false

PMID: 17275324,12055204 SP-A induces NF-KappaB activation and cytokine production such as TNF-alpha and IL-10 in macrophages by stimulating TLR4

Go back
892.0, 1300.0
23.0, 23.0

p51

p52

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e84 e14

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c151 : 1
stoichiometry:c150 : 1

m85*m15*0.1

nodelay

--

true

0

false

PMID: 17275324,12055204 SP-A induces NF-KappaB activation and cytokine production such as TNF-alpha and IL-10 in macrophages by stimulating TLR4

Go back
578.0, 162.0
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e86 e5

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m87*m5*0.1

nodelay

--

true

0

false

PMID: 17275324,15795240 High-mobility group box 1 (HMGB1) was identified as an endogenous ligand for TLR4/MD-2 and TLR2 that serves as a late mediator of lethality in sepsis and as an early mediator of inflammation and organ damage in hepatic ischemia reperfusion injury, a pathophysiologic process whereby hypoxic organ damage is accentuated following return of blood flow and oxygen delivery

Go back
742.0, 178.0
19.0, 19.0

p53

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e86 e19

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m87*m20*0.1

nodelay

--

true

0

false

PMID: 17275324,15795240 High-mobility group box 1 (HMGB1) was identified as an endogenous ligand for TLR4/MD-2 and TLR2 that serves as a late mediator of lethality in sepsis and as an early mediator of inflammation and organ damage in hepatic ischemia reperfusion injury, a pathophysiologic process whereby hypoxic organ damage is accentuated following return of blood flow and oxygen delivery

Go back
906.0, 398.0
19.0, 19.0

p55

p55

cso30:i:ME_Polymerization

cso30:i:CC_Cytoplasm

--

e89 e90 e5

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1

m90*m91*m5*0.1

nodelay

--

true

0

false

PMID: 17275324 Oxidized low-density lipoprotein (OxLDL) induces actin polymerization and spreading of macrophages, which results in pro-atherogenic consequences as inhibition of phagocytosis of apoptotic cells but enhancement of OxLDL uptake. PMID: 17275324,12424240 This effect is mediated by TLR4/MD-2 but not by TLR2

Go back
605.0, 417.0
19.0, 19.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e5 e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m5*m93*0.1

nodelay

--

true

0

false

PMID: 17275324,12411706 Beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. Murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for TLR4, inducing upregulation of co-stimulatory molecules and dendritic cell maturation

Go back
652.0, 1148.0
23.0, 23.0

p57

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e93

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c165 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17275324,12411706 Beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. Murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for TLR4, inducing upregulation of co-stimulatory molecules and dendritic cell maturation

Go back
561.0, 317.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000016573 MO000022528

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m11*m1572*m6810*0.1

nodelay

--

true

0

false

PMID: 17275324 Figure 1 PMID: 17275324 ¡ÆMyD88-dependent¡Ç pathway, requires two adaptor molecules, myeloid differentiation factor 88 (MyD88) and MyD88 adapterlike (Mal)/TIR domain-containing protein (TIRAP), and leads to early activation of the transcription factor NF-KappaB, the production of proinflammatory cytokines, and Th1 responses.

Go back
632.0, 608.0
23.0, 23.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m13*m14*0.1

nodelay

--

true

0

false

PMID: 17275324 Figure 1 PMID: 17275324 ¡ÆMyD88-dependent¡Ç pathway, requires two adaptor molecules, myeloid differentiation factor 88 (MyD88) and MyD88 adapterlike (Mal)/TIR domain-containing protein (TIRAP), and leads to early activation of the transcription factor NF-KappaB, the production of proinflammatory cytokines, and Th1 responses.

Go back
485.0, 961.0
21.0, 21.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e14 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m15*m16*0.1

nodelay

--

true

0

false

PMID: 17275324 Figure 1 PMID: 17275324 ¡ÆMyD88-dependent¡Ç pathway, requires two adaptor molecules, myeloid differentiation factor 88 (MyD88) and MyD88 adapterlike (Mal)/TIR domain-containing protein (TIRAP), and leads to early activation of the transcription factor NF-kappaB, the production of proinflammatory cytokines, and Th1 responses.

Go back
633.0, 325.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000041125 MO000041132

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m11*m18998*m19005*0.1

nodelay

--

true

0

false

PMID: 17275324 Figure 1 PMID: 17275324 A second set of adaptor molecules, TIR domain-containing adapter inducing interferon-beta (TRIF)/TIR domain-containing adapter molecule-1 (TICAM-1) and TRIF-related adapter molecule (TRAM)/TIR domain-containing adapter molecule- 2 (TICAM-2), are required for LPS-induced phosphorylation and dimerization of the transcription factor IRF-3, leading to interferon-beta (IFN-beta) production

Go back
96.0, 104.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 174.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.99740480914465, 904.2037555365387

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 511.8916537154364

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
365.0, 452.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.0, 500.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.0, 674.0438970079874

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
355.0, 454.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.0, 555.4643262341929

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 753.102502099981

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.4984801712582, 637.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.0, 706.1224550271086

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.0, 165.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.0, 825.1118111700375

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
442.63497725054634, 637.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 714.868454316855

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 634.0894526619943

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.76759295178954, 566.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.0, 622.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
140.0, 863.0678003232414

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.8035950723434, 577.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.0, 694.9900439028621

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0593675674598, 550.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
191.61417220995244, 115.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.2281956019666, 1110.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 713.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
534.5047326640744, 1094.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.9005557906725, 700.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.0, 1086.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.9756492514441, 700.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
610.0, 1242.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.0, 713.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.0, 1146.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.8818910154992, 550.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
140.0, 341.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.0, 1126.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
134.0, 523.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
56.0, 559.7348685646834

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
55.0, 717.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 696.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.77421016755645, 959.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.8782684705435, 121.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
392.0, 1144.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.9549721551277, 256.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.1277940306399, 89.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.74929190185685, 368.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 161.54933707270436

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.9596317713671, 160.95135355417779

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 149.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.0, 256.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0, 487.5660474842228

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.0, 480.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 713.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 1213.220317222566

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
955.0, 1167.1119090269774

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 1312.2521269463605

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 244.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.0, 1313.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 713.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.7005280535601, 188.09267876932364

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 178.79996064096832

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.0, 177.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
722.0, 204.9275402799559

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.6014458507486, 193.49359599336725

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.0, 189.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 175.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.0, 408.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 306.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.0, 417.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 252.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.0, 257.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.8642292310659, 440.44158207927734

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 300.8470183397434

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
578.9131331058361, 1171.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0340580137795, 314.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
150.6234062401061, 331.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.0, 320.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
143.0, 471.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 104.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 620.2780926979885

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.4100581234954, 631.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.6482262139794, 713.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
394.0, 989.3883149330392

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
54.99167290972602, 952.3649165712204

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.0, 241.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.8089875327071, 301.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 336.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
654.0, 259.8847154019073

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.2194132667992, 272.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
116.34324486585716, 114.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.0, 443.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 494.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 571.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.0, 677.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
773.0, 1006.5079535053411

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
820.6167322298229, 787.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
827.0, 988.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 206.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.0, 188.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.0, 193.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
120.0, 176.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.9929918681285, 332.3347849997122

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
140.0, 265.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.0, 335.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1182.0, 349.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.0, 444.29609328407906

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1183.1417624473527, 449.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 388.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1281.3812746502558, 349.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1174.9544177959076, 399.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 508.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
140.0, 189.94569211788604

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1333.0, 349.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.7768827048246, 515.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 398.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1278.0496697522246, 502.9308381279197

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.8506811794834, 495.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 522.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1290.0, 589.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1182.719750349256, 667.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
37.0, 535.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
78.76323986558955, 575.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 186.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
71.0, 632.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
62.0, 750.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.87377489980517, 762.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.0, 787.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
134.0, 467.04575599769936

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.0, 348.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
145.90334097874546, 466.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1178.0, 808.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.0, 845.2304815589116

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1181.795325879343, 849.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
300.0, 171.40945205373842

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.0, 920.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 260.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1069.0, 925.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 944.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 1161.9480450613707

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
949.0, 1152.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.0, 945.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.0, 1258.0496045501138

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.0, 1248.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 244.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
384.0, 174.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.0, 244.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
218.1257477847161, 917.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
223.271349126737, 1247.9669085083758

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.99659230057485, 1236.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.38153195365487, 824.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
286.22432190298986, 1068.7937548130558

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
80.0, 1052.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 824.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.7785096065796, 1094.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 745.6428033978249

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
394.0, 163.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 756.6518186410233

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 743.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.6400839476523, 1017.8300782016946

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
443.23944430734275, 824.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
134.28356800364546, 536.7565557170902

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
62.0, 708.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
200.07933894855682, 263.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
141.7323794809094, 719.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
59.0, 717.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.661338475875, 267.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back