1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17276732.csml convertedTime:2009.07.01.11:01

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Therapeutic implications of the TLR and VDR partnership.
Authors Liu PT, Krutzik SR, Modlin RL.
Affiliation Division of Dermatology, Department of Medicine, David Geffen School of Medicineat University of California, Los Angeles, CA 90095, USA.
Abstract The innate immune system provides the host with an immediate and rapid defenseagainst invading microbes. Detection of foreign invaders is mediated by a classof receptors that are known as the pattern recognition receptors, such as thefamily of Toll-like receptors (TLRs). In humans, ten functional TLRs have beenidentified and they respond to conserved pathogen-associated molecular patternsderived from bacteria, mycoplasma, fungi and viruses. TLR activation leads todirect antimicrobial activity against both intracellular and extracellularbacteria, and induces an antiviral gene program. Recently, it was reported thatTLR2 activation leads to the use of vitamin D3 as a mechanism to combatMycobacterium tuberculosis. Here, we focus on recent findings concerning theTLR-induced antimicrobial mechanisms in humans and the therapeutic implicationsof these findings. Owing to their capability to combat a wide array ofpathogens, TLRs are attractive therapeutic targets. However, additionalknowledge about their antimicrobial mechanisms is needed.
PMID 17276732
Model Abstract

Entity

G010228:IFN-beta G010514:iNOS G010808:VDR G022145:viperin G022435:CAMP G024948:DEFB4 G026913:CYP27B1 MO000000058:NF-kappaB MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016658:IFN Type I MO000016660:IFNbeta MO000016882:LPS MO000017793:triacylated lipoprotein MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019399:TLR5 MO000019959:CCR6 MO000021201:iNOS MO000022185:flagellin MO000022224:dsRNA MO000036915:DBP MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042130:TLR11 MO000063808:DEFB4 MO000068831:MAL MO000079001:pre-propeptide/hCAP-18 e1: e10: e11: e12:LPS: TLR4 e13:diacylated lipoprotein e14:TLR2: TLR1 e15:TLR2: TLR6 e16:triacylated lipoprotein: TLR2: TLR1 e17:diacylated lipoprotein: TLR2: TLR6 e18:flagellin: TLR5 e19:ssRNA e2: e20:ssRNA: TLR8 e21:protozoan profilin-like protein e22:protozoan profilin-like protein: TLR11 e23:triacylated lipoprotein: TLR2: TLR1: MAL e24:diacylated lipoprotein: TLR2: TLR6: MAL e25:LPS: TLR4: MAL e26:imidazoquinolines e27:imidazoquinolines: TLR7 e28:triacylated lipoprotein: TLR2: TLR1: MAL: MyD88 e29:diacylated lipoprotein: TLR2: TLR6: MAL: MyD88 e3: e30:imidazoquinolines: TLR7: MyD88 e31:LPS: TLR4: MAL: MyD88 e32:unmethylated DNA e33:unmethylated DNA: TLR9 e34:unmethylated DNA: TLR9: MyD88 e35:imidazoquinolines: TLR8 e36:dsRNA: TLR3: TRIF e37:LPS: TLR4: MAL e38:LPS: TLR4: MAL: TRIF e39:ssRNA: TLR8: MyD88 e4: e40:imidazoquinolines: TLR8: MyD88 e41:IFNalpha e42:IFNalpha e43:IRF-5 {activated} e44:IRF-7 {activated} e45:NF-kappaB {nucleus} e46: cytokines e47:IRF-3 {activated} e48:IFN Type I e49:TLR ligand e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:TLR ligand: TLR e64:DEFB4: TLR4 e65:CAP18(h) e66:LL-37 e67:protease-3 e68:DEFB e69:DEFB: CCR6 e7: e70:L-NAME e71:L-NIL e72:VDR e73:product of CYP27B1 e74:25D3 e75:1, 25D3 e76:1, 25D3: VDR e77:1, 25D3: VDR e78:TACO e79:myxovirus resistance gene e8: e80:2', 5' oligoadenylate synthetase e81:RSAD2 e82:oxygen intermediates e83:NADPH-dependent phagocytic oxidase e84:isatoribine e85:isatoribine: TLR7 e86:CpG oligonucleotides e87:CpG oligonucleotides: TLR9 e88:TLR e89:1alpha,25-dihydroxyvitamin D3 e9: e90:trans retinoic acid e91:DBP: 25D3 {intracellular} e92:DBP: 25D3

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p7 p8 p9
Model Detail
798.0, 1082.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p24 p25

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
486.0, 1238.0
28.0, 28.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p44 p46 p59

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
585.0, 1141.0
29.5, 29.5

VDR

--

G010808

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p51

--

true true true true

csml-variable:Double

m93705

10

false

infinite

0

unit false false false
TRANSFACG010808

--

Go back
745.0, 1029.0
30.0, 30.0

viperin

--

G022145

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m100859

10

false

infinite

0

unit false false false
TRANSFACG022145

--

Go back
586.0, 1366.0
28.0, 28.0

CAMP

--

G022435

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m101149

10

false

infinite

0

unit false false false
TRANSFACG022435

--

Go back
553.0, 1093.0
30.0, 30.0

DEFB4

--

G024948

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m103653

10

false

infinite

0

unit false false false
TRANSFACG024948

--

Go back
669.0, 1161.0
30.0, 30.0

CYP27B1

--

G026913

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p52

--

true true true true

csml-variable:Double

m105616

10

false

infinite

0

unit false false false
TRANSFACG026913

--

Go back
980.0, 1082.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
864.0, 500.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p38

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
660.0, 586.0
30.5, 30.5

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p31 p32

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
680.0, 738.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
465.0, 369.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13 p14 p15 p17 p22 p23

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
848.0, 892.0
32.0, 32.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
953.0, 959.0
28.0, 28.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p25

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1036.0, 192.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
193.0, 179.0
28.0, 28.0

triacylated lipoprotein

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
1218.0, 1162.0
28.0, 28.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p45 p47

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
1040.0, 256.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p42

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
608.0, 278.0
30.0, 30.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
799.0, 295.0
26.0, 26.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
258.0, 950.0
28.0, 28.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
426.0, 1422.0
28.0, 28.0

CCR6

--

MO000019959

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m4487

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000019959

--

Go back
350.0, 1386.0
28.0, 28.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44 p46 p59

--

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
136.0, 944.0
32.0, 32.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
840.0, 148.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1030.0, 1262.0
28.0, 28.0

DBP

--

MO000036915

cso30:c:Protein

cso30:i:CC_CellComponent

--

p68

--

true true true true

csml-variable:Double

m15225

10

false

infinite

0

unit false false false
InterProIPR004827
TRANSPATHMO000036915

--

Go back
952.0, 440.0
23.0, 23.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p21

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
967.0, 391.0
26.0, 26.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
845.0, 277.0
29.0, 29.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p19

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
329.0, 723.0
28.0, 28.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p18

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
322.0, 808.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p65

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
326.0, 636.0
25.0, 25.0

TLR7

--

MO000042126

cso30:c:Complex

cso30:i:CC_CellComponent

--

--

p11 p64

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
258.0, 1034.0
27.0, 27.0

TLR11

--

MO000042130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19944

10

false

infinite

0

unit false false false
TRANSPATHMO000042130

--

Go back
1033.0, 609.0
29.0, 29.0

DEFB4

--

MO000063808

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m38682

10

false

infinite

0

unit false false false
TRANSPATHMO000063808

--

Go back
385.0, 373.0
30.0, 30.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9 p10

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
759.0, 1447.0
26.0, 26.0

pre-propeptide/hCAP-18

--

MO000079001

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p49

true true true true

csml-variable:Double

m286360

10

false

infinite

0

unit false false false
Affymetrix210244_at
EnsemblENSG00000164047
HGNCCAMP
OMIM600474
ProteomeHumanPSD/CAMP
RefSeqNM_004345
TRANSPATHMO000079001
UnigeneHs.112760
UniProtP49913

--

Go back
234.08039642585143, 271.6216765777039
933.2105155838792, 1371.5086356695417

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
244.71405150148775, 347.2287027359596
861.0434633109968, 1225.9836453253017

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
332.0, 527.0
237.04723797242676, 395.7483549200687

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
1111.5, 304.0
32.17947008831861, 39.40343276120647

LPS: TLR4

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p10 p20

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
181.0, 375.0
28.0, 28.0

diacylated lipoprotein

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
261.25, 276.0
28.886309414571485, 40.30647825289044

TLR2: TLR1

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
258.25, 317.0
27.323820884565976, 38.126261699394384

TLR2: TLR6

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
312.25, 287.0
24.20673518076711, 33.7768397871169

triacylated lipoprotein: TLR2: TLR1

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
257.25, 364.0
27.600018351991196, 38.511653514406305

diacylated lipoprotein: TLR2: TLR6

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
256.75, 989.0
30.28920179970005, 37.08881853024496

flagellin: TLR5

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
152.0, 676.75
39.827255278310936, 21.904990403071018

ssRNA

--

e19

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
234.08039642585143, 271.6216765777039
933.2105155838792, 1371.5086356695417

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
329.75, 673.0
26.7291284785869, 32.729545075820695

ssRNA: TLR8

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p22

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
175.0, 1092.5
34.58699472759227, 22.48154657293497

protozoan profilin-like protein

--

e21

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
259.75, 1073.0
24.5, 30.0

protozoan profilin-like protein: TLR11

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
361.25, 260.0
28.87841805835933, 40.2954670581758

triacylated lipoprotein: TLR2: TLR1: MAL

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p8

p14

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
262.25, 415.0
26.029638465773534, 36.320425766195626

diacylated lipoprotein: TLR2: TLR6: MAL

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p13

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1110.25, 356.0
28.27078363002386, 39.44760506514957

LPS: TLR4: MAL

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p15

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
167.0, 637.5
39.91589571068124, 22.61900756938604

imidazoquinolines

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p11 p18

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
322.75, 590.0
24.5, 30.0

imidazoquinolines: TLR7

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

p12

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
439.25, 268.0
34.29188841989356, 47.84914663240961

triacylated lipoprotein: TLR2: TLR1: MAL: MyD88

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p14

p44 p45 p57

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
255.25, 469.0
32.59524683428152, 45.4817397687649

diacylated lipoprotein: TLR2: TLR6: MAL: MyD88

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p46 p47

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
252.74460673752893, 290.51298009932293
895.882094960524, 1333.726028626304

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
513.25, 586.0
27.5211047898697, 38.40154156726004

imidazoquinolines: TLR7: MyD88

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p29 p30 p33

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1110.25, 399.0
35.49926592035236, 49.53385942374747

LPS: TLR4: MAL: MyD88

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p35

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
167.0, 808.75
47.951002227171486, 16.78285077951002

unmethylated DNA

--

e32

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p16

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
326.75, 850.0
30.599483419430097, 37.46875520746542

unmethylated DNA: TLR9

--

e33

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p16

p17

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
497.25, 850.0
27.25279867865663, 38.02716094696274

unmethylated DNA: TLR9: MyD88

--

e34

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p17

p28 p34

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
326.75, 766.0
24.5, 30.0

imidazoquinolines: TLR8

--

e35

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p18

p23

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
921.5, 242.0
26.885850614791707, 37.51514039273262

dsRNA: TLR3: TRIF

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p25 p37 p61 p62 p60

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1108.25, 466.0
31.86135070655166, 44.45769866030465

LPS: TLR4: MAL

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1112.25, 534.0
30.843365755184436, 43.03725454211782

LPS: TLR4: MAL: TRIF

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p24 p38

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
548.25, 669.0
29.146724169572398, 40.66984767847311

ssRNA: TLR8: MyD88

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p26 p31

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
287.2733958141327, 323.572761262156
826.8245168073171, 1267.6064663006364

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
541.25, 762.0
27.386951734263164, 38.214351257111396

imidazoquinolines: TLR8: MyD88

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p27 p32

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
572.0, 914.0
30.0, 30.0

IFNalpha

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p27 p28 p29

--

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
580.0, 1020.0
32.0, 32.0

IFNalpha

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p26 p27 p28 p29

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSFACG010227

--

Go back
664.0, 678.0
30.5, 30.5

IRF-5 {activated}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p31 p32

--

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
680.0, 794.0
30.0, 30.0

IRF-7 {activated}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p34

--

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
809.0, 1129.0
30.0, 30.0

NF-kappaB {nucleus}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p36

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
799.0, 1189.0
42.8719723183391, 22.865051903114185

cytokines

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p36 p45 p47

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
864.0, 540.0
32.0, 32.0

IRF-3 {activated}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37 p38

p39

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
741.0, 1094.0
38.615916955017305, 20.59515570934256

IFN Type I

--

e48

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p39

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
584.0, 211.25
30.0, 19.5

TLR ligand

--

e49

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
332.0, 527.0
237.04723797242676, 395.7483549200687

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
426.25696897016894, 978.5971638191462
483.07924299438963, 443.4302931635693

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
478.43312556919045, 989.1058171208745
282.47091676022046, 429.77227592033813

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
432.55409131832675, 984.5156379578797
470.4849982980744, 431.59334488610216

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
433.4536802252064, 985.4261724407618
468.6858204843147, 429.77227592033813

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
426.25696897016894, 978.5971638191462
483.07924299438963, 443.4302931635693

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
426.25696897016894, 978.5971638191462
483.07924299438963, 443.4302931635693

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
433.4536802252064, 985.4261724407618
468.6858204843147, 429.77227592033813

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
778.8958204670043, 1160.7040603955606
30.180136821420827, 27.65338859363315

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
699.7319966615926, 1288.1788879990506
85.46094615356984, 78.30596552785826

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
426.25696897016894, 978.5971638191462
483.07924299438963, 443.4302931635693

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
332.0, 527.0
237.04723797242676, 395.7483549200687

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
540.1160284441371, 1175.6539220063596
15.298409815245966, 7.455524214313023

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
539.6051712370089, 1153.4197845325039
52.36286373063812, 95.39996195177629

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
561.5720311435209, 1215.468540273497
8.17371531405082, 8.273167432132357

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
706.75, 282.0
24.5, 30.0

TLR ligand: TLR

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

p40 p51 p52

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1112.75, 649.0
30.648475254124314, 37.528745209131806

DEFB4: TLR4

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
707.0, 1359.0
26.0, 26.0

CAP18(h)

--

e65

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p55

p48

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
Affymetrix210244_at
EnsemblENSG00000164047
HGNCCAMP
OMIM600474
ProteomeHumanPSD/CAMP
RefSeqNM_004345
TRANSFACG018988
UnigeneHs.112760

--

Go back
817.0, 1505.0
29.0, 29.0

LL-37

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
Affymetrix210244_at
EnsemblENSG00000164047
HGNCCAMP
OMIM600474
ProteomeHumanPSD/CAMP
RefSeqNM_004345
TRANSPATHMO000079001
UnigeneHs.112760
UniProtP49913

--

Go back
701.0, 1508.75
30.0, 22.5

protease-3

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
481.0, 1478.75
30.0, 18.5

DEFB

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
367.75, 1473.0
24.5, 30.0

DEFB: CCR6

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
245.75148126496444, 276.8751857891515
871.1543963020529, 1249.4226432486307

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
310.0, 1309.5
36.888141295206054, 20.903280067283433

L-NAME

--

e70

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p44 p46 p59

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
318.0, 1353.5
35.57611438183347, 20.159798149705633

L-NIL

--

e71

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p44 p46 p59

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
985.0, 1433.0
30.0, 30.0

VDR

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p59

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000047518

--

Go back
1050.75, 1365.0
18.5, 30.0

product of CYP27B1

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
925.0, 1327.5
30.0, 17.0

25D3

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p68

p53 p57

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1053.0, 1423.5
30.0, 17.0

1, 25D3

--

e75

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p53

p54 p63

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
923.75, 1445.0
24.5, 30.0

1, 25D3: VDR

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p56

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
859.75, 1385.0
24.5, 30.0

1, 25D3: VDR

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p55 p58

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
700.0, 1317.0
40.48442906574394, 21.591695501730104

TACO

--

e78

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p58

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
769.0, 1244.0
39.08304498269896, 20.844290657439448

myxovirus resistance gene

--

e79

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p61

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
248.86377055539455, 298.926288115763
835.7087928483028, 1228.2135779184698

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
746.0, 1283.0
35.19031141868512, 18.768166089965398

2', 5' oligoadenylate synthetase

--

e80

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p60

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
737.0, 897.0
30.0, 30.0

RSAD2

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

--

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000060601

--

Go back
932.0, 1496.5
39.91589571068124, 22.61900756938604

oxygen intermediates

--

e82

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p63

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
873.0, 1546.75
30.0, 18.5

NADPH-dependent phagocytic oxidase

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p63

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
165.0, 595.5
35.29857022708158, 20.00252312867957

isatoribine

--

e84

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p64

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
339.75, 533.0
24.5, 30.0

isatoribine: TLR7

--

e85

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p64

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
169.0, 898.75
41.0022271714922, 14.35077951002227

CpG oligonucleotides

--

e86

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p65

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
375.75, 893.0
24.5, 30.0

CpG oligonucleotides: TLR9

--

e87

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p65

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
516.0, 1157.0
40.32871972318339, 21.508650519031143

TLR

--

e88

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
369.0, 1119.5
30.65601345668629, 17.371740958788898

1alpha,25-dihydroxyvitamin D3

--

e89

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p66

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
257.16320866320825, 320.9773904423745
831.8933237939345, 1212.1058646065446

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
367.0, 1158.5
33.96131202691337, 19.244743481917578

trans retinoic acid

--

e90

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p66

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1233.5, 1319.0
28.072321279786696, 34.37427095484085

DBP: 25D3 {intracellular}

--

e91

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p67

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1053.5, 1319.0
28.072321279786696, 34.37427095484085

DBP: 25D3

--

e92

cso30:c:Complex

cso30:i:CC_Extracellular

--

p67

p68

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
847.0, 199.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17276732 TLRs recognize various conserved pathogen-associated molecules, including triacylated lipoproteins (TLR2?TLR1), diacylated lipoproteins (TLR2?TLR6), double-stranded (ds)RNA (TLR3), lipopolysaccharide (LPS) (TLR4), flagellin (TLR5), single-stranded (ss)RNA (TLR8) and unmethylated DNA (TLR9).

Go back
1216.0, 312.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000068831 e12

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m43675*m12*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

Go back
250.0, 636.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e26 MO000042126

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m26*m19940*0.1

nodelay

--

true

0

false

PMID: 17276732, 11812998 The imidazoquinolines, which currently include imiquimod and resisquimod, are routinely used to treat genital warts and genital herpes, which are caused by the human papilloma virus (HPV) and HSV, respectively. Imiquimod stimulates cells via TLR7 and resisquimod via both TLR7 and TLR8.

Go back
370.0, 592.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000016573

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m27*m1572*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

Go back
334.0, 420.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000016573

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m24*m1572*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

Go back
405.0, 337.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016573

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m23*m1572*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

Go back
1216.0, 408.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e25

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m1572*m25*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

Go back
178.0, 856.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m19828*m32*0.1

nodelay

--

true

0

false

PMID: 17276732 TLRs recognize various conserved pathogen-associated molecules, including triacylated lipoproteins (TLR2?TLR1), diacylated lipoproteins (TLR2?TLR6), double-stranded (ds)RNA (TLR3), lipopolysaccharide (LPS) (TLR4), flagellin (TLR5), single-stranded (ss)RNA (TLR8) and unmethylated DNA (TLR9).

Go back
391.0, 857.0
23.0, 23.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e33 MO000016573

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c49 : 1
stoichiometry:c51 : 1

m33*m1572*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

Go back
256.0, 770.0
22.0, 22.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e26 MO000042007

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m26*m19823*0.1

nodelay

--

true

0

false

PMID: 17276732, 11812998 The imidazoquinolines, which currently include imiquimod and resisquimod, are routinely used to treat genital warts and genital herpes, which are caused by the human papilloma virus (HPV) and HSV, respectively. Imiquimod stimulates cells via TLR7 and resisquimod via both TLR7 and TLR8.

Go back
953.0, 349.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17276732, 16675322 Similar to MyD88?TIRAP complex, TRIF associates directly with TLR3 and indirectly with TLR4 through TRIF-related adaptor molecule (TRAM).

Go back
1117.0, 257.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17276732 TLRs recognize various conserved pathogen-associated molecules, including triacylated lipoproteins (TLR2?TLR1), diacylated lipoproteins (TLR2?TLR6), double-stranded (ds)RNA (TLR3), lipopolysaccharide (LPS) (TLR4), flagellin (TLR5), single-stranded (ss)RNA (TLR8) and unmethylated DNA (TLR9).

Go back
987.0, 441.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 e12

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m19005*m12*0.1

nodelay

--

true

0

false

PMID: 17276732, 16675322 Similar to MyD88?TIRAP complex, TRIF associates directly with TLR3 and indirectly with TLR4 through TRIF-related adaptor molecule (TRAM).

Go back
1031.0, 483.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m18998*m37*0.1

nodelay

--

true

0

false

PMID: 17276732, 16675322 Similar to MyD88?TIRAP complex, TRIF associates directly with TLR3 and indirectly with TLR4 through TRIF-related adaptor molecule (TRAM).

Go back
376.0, 678.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e20

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c68 : 1

m1572*m20*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
380.0, 770.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e35

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c69 : 1

m1572*m35*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
890.0, 1014.0
27.0, 27.0

p24

p24

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e38

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c75 : 1
stoichiometry:c70 : 1

m93217*m38*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
866.0, 980.0
25.0, 25.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e36

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c71 : 1

m93217*m36*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
603.0, 861.0
23.0, 23.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e39 e42

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c87 : 1
stoichiometry:c78 : 1

m39*m42*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
538.0, 860.0
26.0, 26.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e42

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c86 : 1
stoichiometry:c77 : 1

m40*m42*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
506.0, 916.0
25.0, 25.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e34 e42

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c84 : 1
stoichiometry:c76 : 1

m34*m42*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
651.0, 917.0
23.0, 23.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e30 e42

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c79 : 1

m30*m42*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, activation of TLR7, TLR8 and TLR9 results in MyD88-dependent production of IFN-alpha, in contrast to the TLR3- and TLR4-mediated IFN-beta production, which is MyD88-independent.

Go back
263.0, 181.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 MO000017793

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m2549*0.1

nodelay

--

true

0

false

PMID: 17276732 TLRs recognize various conserved pathogen-associated molecules, including triacylated lipoproteins (TLR2?TLR1), diacylated lipoproteins (TLR2?TLR6), double-stranded (ds)RNA (TLR3), lipopolysaccharide (LPS) (TLR4), flagellin (TLR5), single-stranded (ss)RNA (TLR8) and unmethylated DNA (TLR9).

Go back
607.0, 589.0
23.0, 23.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e30

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c98 : 1
stoichiometry:c89 : 1

m979*m30*0.1

nodelay

--

true

0

false

PMID: 17276732 Studies have shown that TLR7 and TLR9 stimulation results in the activation of IRF-7, whereas IRF-5 is activated by TLR7 and TLR8.

Go back
607.0, 637.0
23.0, 23.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e39

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c99 : 1
stoichiometry:c91 : 1

m979*m39*0.1

nodelay

--

true

0

false

PMID: 17276732 Studies have shown that TLR7 and TLR9 stimulation results in the activation of IRF-7, whereas IRF-5 is activated by TLR7 and TLR8.

Go back
607.0, 681.0
23.0, 23.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c100 : 1
stoichiometry:c93 : 1

m979*m40*0.1

nodelay

--

true

0

false

PMID: 17276732 Studies have shown that TLR7 and TLR9 stimulation results in the activation of IRF-7, whereas IRF-5 is activated by TLR7 and TLR8.

Go back
623.0, 741.0
23.0, 23.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e30

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c101 : 1
stoichiometry:c95 : 1

m980*m30*0.1

nodelay

--

true

0

false

PMID: 17276732 Studies have shown that TLR7 and TLR9 stimulation results in the activation of IRF-7, whereas IRF-5 is activated by TLR7 and TLR8.

Go back
631.0, 797.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e34

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c102 : 1
stoichiometry:c97 : 1

m980*m34*0.1

nodelay

--

true

0

false

PMID: 17276732 Studies have shown that TLR7 and TLR9 stimulation results in the activation of IRF-7, whereas IRF-5 is activated by TLR7 and TLR8.

Go back
853.0, 1083.0
27.0, 27.0

p35

p35

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000058 e31

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m45*m31*0.1

nodelay

--

true

0

false

PMID: 17276732 The MyD88-dependent signaling pathway induces translocation of the transcription factor nuclear factor-kappaB (NF-kappaB) into the nucleus, resulting in the transcription of immune genes.

Go back
935.0, 1131.0
25.0, 25.0

p36

p36

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e45 e46

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m46*m47*0.1

nodelay

--

true

0

false

PMID: 17276732 The outcomes of the NF-kappaB-mediated transcription include the production and secretion of inflammatory cytokines, and the induction of direct antimicrobial mechanisms.

Go back
950.0, 502.0
27.0, 27.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e36

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c114 : 1
stoichiometry:c110 : 1

m977*m36*0.1

nodelay

--

true

0

false

PMID: 17276732 By contrast, the TRIF-mediated pathway, which is commonly known as the MyD88-independent pathway, results in the activation of interferon regulatory factor-3 (IRF-3), leading to the transcription of type 1 interferons (IFNs).

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955.0, 543.0
25.0, 25.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e38

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1

m977*m38*0.1

nodelay

--

true

0

false

PMID: 17276732 By contrast, the TRIF-mediated pathway, which is commonly known as the MyD88-independent pathway, results in the activation of interferon regulatory factor-3 (IRF-3), leading to the transcription of type 1 interferons (IFNs).

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818.0, 972.0
25.0, 25.0

p39

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e48 e47

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m49*m48*0.1

nodelay

--

true

0

false

PMID: 17276732 By contrast, the TRIF-mediated pathway, which is commonly known as the MyD88-independent pathway, results in the activation of interferon regulatory factor-3 (IRF-3), leading to the transcription of type 1 interferons (IFNs).

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184.0, 324.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e13

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m15*m13*0.1

nodelay

--

true

0

false

PMID: 17276732 TLRs recognize various conserved pathogen-associated molecules, including triacylated lipoproteins (TLR2?TLR1), diacylated lipoproteins (TLR2?TLR6), double-stranded (ds)RNA (TLR3), lipopolysaccharide (LPS) (TLR4), flagellin (TLR5), single-stranded (ss)RNA (TLR8) and unmethylated DNA (TLR9).

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657.0, 1041.0
21.0, 21.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e63

G024948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17276732 Although it is clear that TLR activation results in the expression of antimicrobial peptides, especially human defensin beta4 (DEFB4), little is known about the TLR-induced direct antimicrobial functions in epithelial cells.

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663.0, 209.0
23.0, 23.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e49 MO000019395

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m63*m3962*0.1

nodelay

--

true

0

false

PMID: 17276732 Although it is clear that TLR activation results in the expression of antimicrobial peptides, especially human defensin beta4 (DEFB4), little is known about the TLR-induced direct antimicrobial functions in epithelial cells.

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1204.0, 612.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000063808 MO000019394

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c123 : 1
stoichiometry:c125 : 1

m38682*m3961*0.1

nodelay

--

true

0

false

PMID: 17276732, 12411706 DEFB4 can also induce dendritic-cell activation and maturation in a TLR4-dependent manner.

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1196.0, 654.0
29.0, 29.0

p43

p43

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e64

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17276732, 12411706 DEFB4 can also induce dendritic-cell activation and maturation in a TLR4-dependent manner.

Go back
380.0, 1238.0
25.0, 25.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010514 e28 e70 e71

MO000021201

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c131 : 1
stoichiometry:c146 : 1
stoichiometry:c148 : 1
stoichiometry:c127 : 1

m93479*m28*0.1

nodelay

--

true

0

false

PMID: 17276732, 10426995 In 1999, it was demonstrated that activation of TLR2 by its ligand, the Mycobacterium tuberculosis-derived 19-kDa lipoprotein, resulted in the activation of host-defense mechanisms from monocytes and macrophages, including the secretion of cytokines and inducible nitric-oxide synthase (iNOS) promoter activity. PMID: 17276732 This was shown by using iNOS inhibitors l-NIL and l-NAME, which could ablate the TLR2-mediated antimicrobial activity in murine cells, but had no effect on human cells.

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939.0, 1163.0
25.0, 25.0

p45

p45

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e46 e28

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c132 : 1
stoichiometry:c130 : 1

m47*m28*0.1

nodelay

--

true

0

false

PMID: 17276732, 10426995 In 1999, it was demonstrated that activation of TLR2 by its ligand, the Mycobacterium tuberculosis-derived 19-kDa lipoprotein, resulted in the activation of host-defense mechanisms from monocytes and macrophages, including the secretion of cytokines and inducible nitric-oxide synthase (iNOS) promoter activity.

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399.0, 1275.0
25.0, 25.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e29 e70 e71 G010514

MO000021201

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c171 : 1
stoichiometry:c136 : 1

m29*m93479*0.1

nodelay

--

true

0

false

PMID: 17276732, 10426995 In 1999, it was demonstrated that activation of TLR2 by its ligand, the Mycobacterium tuberculosis-derived 19-kDa lipoprotein, resulted in the activation of host-defense mechanisms from monocytes and macrophages, including the secretion of cytokines and inducible nitric-oxide synthase (iNOS) promoter activity. PMID: 17276732 This was shown by using iNOS inhibitors l-NIL and l-NAME, which could ablate the TLR2-mediated antimicrobial activity in murine cells, but had no effect on human cells.

Go back
947.0, 1211.0
25.0, 25.0

p47

p47

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e29 e46

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c137 : 1
stoichiometry:c135 : 1

m29*m47*0.1

nodelay

--

true

0

false

PMID: 17276732, 10426995 In 1999, it was demonstrated that activation of TLR2 by its ligand, the Mycobacterium tuberculosis-derived 19-kDa lipoprotein, resulted in the activation of host-defense mechanisms from monocytes and macrophages, including the secretion of cytokines and inducible nitric-oxide synthase (iNOS) promoter activity.

Go back
708.0, 1448.0
23.0, 23.0

p48

p48

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e65

MO000079001

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 17276732, 12960280 Although most mammals have multiple cathelicidin family members, humans have only one type of cathelicidin, which is encoded by the hCAP18 gene.

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759.0, 1507.0
25.0, 25.0

p49

p49

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000079001 e67

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c141 : 1

m286360*m68*0.1

nodelay

--

true

0

false

PMID; 17276732, 11389039 Human cathelicidin is stored as a 17-kDa pre-propeptide or cationic antimicrobial peptide (hCAP-18) in secretory granules, and is then processed into a mature 5-kDa form (LL-37) by protease-3 during or after secretion.

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187.0, 951.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17276732 TLRs recognize various conserved pathogen-associated molecules, including triacylated lipoproteins (TLR2?TLR1), diacylated lipoproteins (TLR2?TLR6), double-stranded (ds)RNA (TLR3), lipopolysaccharide (LPS) (TLR4), flagellin (TLR5), single-stranded (ss)RNA (TLR8) and unmethylated DNA (TLR9).

Go back
428.0, 1476.0
23.0, 23.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019959 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m4487*m69*0.1

nodelay

--

true

0

false

PMID: 17276732, 16083775 In addition, some of the DEFB members function as chemoattractants for neutrophils, immature dendritic cells and memory T cells through interaction with chemokine (C-C motif) receptor 6 (CCR-6).

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672.0, 1100.0
23.0, 23.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e63

G010808

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c150 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17276732, 16497887 However, it was recently demonstrated that TLR activation in human monocytes results in the expression of the vitamin-D receptor (VDR) and the 1alpha-vitamin D hydroxylase (Cyp27B1).

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720.0, 1132.0
23.0, 23.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e63

G026913

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17276732, 16497887 However, it was recently demonstrated that TLR activation in human monocytes results in the expression of the vitamin-D receptor (VDR) and the 1alpha-vitamin D hydroxylase (Cyp27B1).

Go back
927.0, 1367.0
25.0, 25.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e73 e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m74*m75*0.1

nodelay

--

true

0

false

PMID: 17276732 The gene product of Cyp27B1 converts inactive vitamin D3 prohormone (25D3) into its active form (1,25D3), which can then bind to and activate the VDR.

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924.0, 1400.0
23.0, 23.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e75 e72

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m76*m73*0.1

nodelay

--

true

0

false

PMID: 17276732 The gene product of Cyp27B1 converts inactive vitamin D3 prohormone (25D3) into its active form (1,25D3), which can then bind to and activate the VDR.

Go back
752.0, 1360.0
23.0, 23.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c161 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 17276732 Activation of the VDR in monocytes results in the expression of the antimicrobial peptide cathelicidin in its active LL-37 form.

Go back
858.0, 1446.0
27.0, 27.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17276732 The gene product of Cyp27B1 converts inactive vitamin D3 prohormone (25D3) into its active form (1,25D3), which can then bind to and activate the VDR.

Go back
588.0, 1324.0
23.0, 23.0

p57

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28 e74

G022435

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c164 : 1

m28*m75*0.1

nodelay

--

true

0

false

PMID: 17276732 Interestingly, the ability of TLR2?TLR1 activation to induce cathelicidin mRNA expression depends on adequate 25D3 concentrations in the serum that is used to culture the cells.

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760.0, 1316.0
23.0, 23.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c169 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17276732, 16040207, 14550285 Furthermore, VDR activation was demonstrated to downregulate transcription of Trp?Asp-containing coat protein (TACO) [45], which has a role in M. tuberculosis entry and survival in human macrophages.

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447.0, 1351.0
25.0, 25.0

p59

p59

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010514 e72 e70 e71

MO000021201

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c172 : 1

m93479*m73*0.1

nodelay

--

true

0

false

PMID: 17276732, 9632843, 14749681 There is evidence that iNOS gene expression is regulated by the VDR in both species.

Go back
254.0, 676.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e19 MO000042007

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19*m19823*0.1

nodelay

--

true

0

false

PMID: 17276732 TLRs recognize various conserved pathogen-associated molecules, including triacylated lipoproteins (TLR2?TLR1), diacylated lipoproteins (TLR2?TLR6), double-stranded (ds)RNA (TLR3), lipopolysaccharide (LPS) (TLR4), flagellin (TLR5), single-stranded (ss)RNA (TLR8) and unmethylated DNA (TLR9).

Go back
818.0, 1278.0
27.0, 27.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c176 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506, 15634923 Stimulation of UECs with dsRNA upregulates mRNA expression of antiviral genes IFN-beta, myxovirus resistance gene [1] and 2¡ì,5¡ì olioadenylate.

Go back
838.0, 1238.0
27.0, 27.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c175 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506, 15634923 Stimulation of UECs with dsRNA upregulates mRNA expression of antiviral genes IFN-beta, myxovirus resistance gene [1] and 2¡ì,5¡ì olioadenylate.

Go back
769.0, 949.0
21.0, 21.0

p62

p62

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G022145 e36

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c179 : 1

m100859*m36*0.1

nodelay

--

true

0

false

PMID: 17276732, 16982913 Also in 2006, it was demonstrated that TLR3 activation on human fetal astrocytes results in an antiviral state that arises from the TLR3-dependent induction of viperin (also known as cig5) against a pseudotyped HIV particle.

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938.0, 1542.0
27.0, 27.0

p63

p63

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e75 e83

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m76*m84*0.1

nodelay

--

true

0

false

PMID: 17276732 In 2001, the 1,25D3-induced antimicrobial activity was reported to be regulated by phosphatidylinositol 3-kinase (PI3-K) and mediated by the generation of oxygen intermediates via nicotinamide adenine dinucleotide phosphate (NADPH)-dependent phagocyte oxidase.

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256.0, 536.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e84 MO000042126

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m85*m19940*0.1

nodelay

--

true

0

false

PMID: 17276732, 16116638 Another TLR7 agonist, isatoribine, is effective against hepatitis C.

Go back
256.0, 896.0
23.0, 23.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m19828*m87*0.1

nodelay

--

true

0

false

PMID: 17276732, 16763660 However, a class of TLR9-stimulating CpG oligonucleotides is currently undergoing human clinical trials for the treatment of hepatitis B [54] and, if successful, it can yield a new class of antiviral therapeutic compounds.

Go back
456.0, 1156.0
23.0, 23.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e89 e90

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c191 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17276732, 16497887, 16402404 Both vitamin D3 and vitamin A derivatives, such as 1alpha,25-dihydroxyvitamin D3 and all-trans retinoic acid, decrease cell surface expression of TLRs and dampen their function.

Go back
1116.0, 1324.0
23.0, 23.0

p67

p67

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 17276732 The intracellular pool of 25D3 is shuttled into the cell via the vitamin D binding protein (DBP).

Go back
995.0, 1323.0
25.0, 25.0

p68

p68

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e92

e74 MO000036915

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 17276732 The intracellular pool of 25D3 is shuttled into the cell via the vitamin D binding protein (DBP).

Go back
180.0, 1036.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 MO000042130

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m21*m19944*0.1

nodelay

--

true

0

false

PMID: 17276732, 15001781, 15860593 Murine TLR11 recognizes a protozoan profilin-like protein and uropathogenic bacteria.

Go back
316.0, 352.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000068831

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m16*m43675*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

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320.0, 384.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000068831

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m17*m43675*0.1

nodelay

--

true

0

false

PMID: 17276732, 15728506 MyD88 directly associates with TLR5, TLR7 and TLR9 and indirectly with TLR2 and TLR4 through another adaptor called MyD88 adaptor-like (MAL) [also known as TIR domain-containing adaptor protein (TIRAP)].

Go back
858.0, 180.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.1111003959261, 211.99922850667645

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
569.0, 710.4795369723441

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.0, 624.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
525.0, 817.356809122592

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
888.0, 1097.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.3343588757587, 1110.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.672031846202, 433.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.0, 1144.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
960.0, 1145.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.0, 1153.1608889027423

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 516.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.0, 193.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.2597352569587, 523.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 523.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.0, 556.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 556.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 280.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 1003.8661812759593

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
832.9139761833155, 572.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
837.0, 931.3846153846154

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 221.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 238.5003060050375

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 204.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.0, 232.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.5365123180184, 312.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.9574873218896, 1058.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1055.0, 283.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1062.0, 624.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1150.1787997289646, 630.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1143.0, 668.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.53208287535716, 1263.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.99939040652174, 1251.0987579062535

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
842.0, 1179.4596177310111

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
220.0, 964.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.0, 1176.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.56579324521226, 131.50233400849714

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
114.5947103320213, 152.71661820771573

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
40.17439973019111, 494.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
71.69823166288154, 492.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
972.0, 1179.4085409836266

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
373.16166426673345, 1300.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.0, 1204.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
731.0, 1460.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 1385.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
168.0, 962.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0, 1473.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 1520.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 1520.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
440.0, 1450.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.0, 1488.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 1488.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
338.0, 1265.9200855945285

c146

c146

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
347.0, 1294.4359163172355

c147

c147

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
341.0, 1266.5698285757726

c148

c148

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
347.0, 1302.854736353966

c149

c149

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
212.0, 971.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.0793457790559, 1118.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.3347319859365, 312.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
705.6564023547028, 1152.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.0, 312.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
960.0, 1380.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
940.0, 1345.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 1385.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
954.9103926934927, 1415.1940215386403

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0019322835142, 1421.869488893521

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 1423.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
192.0, 688.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 1460.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.0, 1372.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 1423.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.7447943425558, 1377.0045350063085

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 1347.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
11.92750534447623, 107.52059037403842

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.0, 1336.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.0, 1326.0

c167

c167

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
354.0, 1364.0

c168

c168

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
748.0, 1329.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.79922153369904, 701.2155173508934

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.254933884827, 1338.3249527748765

c170

c170

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
431.4195317762593, 1258.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.4861652793937, 1369.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.6625609418811, 1266.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
473.9793430476847, 1382.261480880229

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.9955592558332, 1252.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 1292.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.9999999957034, 168.00346860449974

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
852.9999980984843, 147.50996514435428

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
765.0698344970132, 933.8874122257146

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 689.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 977.7838630032043

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.7391510926693, 280.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
970.4811176394367, 1441.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
952.0, 1527.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 1556.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
198.0, 560.5418636464293

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.59340594545733, 565.5498566259299

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.0, 548.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.8973855439313, 834.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.0, 907.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
192.0, 1067.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.0, 908.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.0, 1168.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 1135.0

c192

c192

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
401.0, 1168.0

c193

c193

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1147.0, 1336.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1090.0, 1336.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.0, 1336.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.0, 1336.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.0, 1296.8415826524322

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 231.17551605402411

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.0, 1048.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 1054.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
325.0, 321.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.6058387158518, 370.4801647986473

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.0, 306.98691099462604

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.0, 386.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.94390619355954, 390.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.7839864320407, 404.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.0, 128.1145867044238

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 324.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 224.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.1367843791982, 330.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 649.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.0, 649.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 617.1369251194046

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 300.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.96782774194344, 357.93056949545525

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 322.50986776965385

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.0, 433.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
366.50795350534105, 390.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.3000400080607, 443.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1066.0, 219.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.0, 605.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.1925881887881, 399.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 605.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.2558737150498, 109.34683224990044

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1139.0, 382.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1153.9926631665414, 420.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
210.58306997992312, 825.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
191.0, 826.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 869.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.25921447872463, 399.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.0, 270.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.0, 869.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
414.0, 869.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.0, 660.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.89547372126214, 745.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.0, 781.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
874.0, 301.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.0, 378.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.3292929262616, 287.6533910434309

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
985.0, 417.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.6846515535792, 341.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1129.399500935551, 284.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.0, 456.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
975.0, 458.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.9632722328022, 490.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.0, 505.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.3314757723955, 399.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
394.76660522078237, 399.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 689.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 781.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 689.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.0, 781.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 336.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 990.3149107106393

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.0, 977.7620869714772

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 1042.8

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
821.0, 1011.7095390559515

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
880.6153146977997, 280.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
914.4246907579123, 577.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.0, 929.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 886.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.5777087639997, 884.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 929.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
195.0, 354.9949028347804

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 888.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.2665186418611, 800.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.0, 710.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.0, 624.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.6809255792191, 947.4875986097949

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.0, 946.7839864320407

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.1292760037462, 893.7114320135673

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
598.0, 891.945204834583

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 601.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.0, 612.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 343.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.0455126623185, 614.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 657.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.2399915200255, 617.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 693.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 753.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 763.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.4513482233507, 768.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
654.0, 809.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.0, 601.3632612873492

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.0, 661.5876987549067

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back