1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17303405.csml convertedTime:2009.07.01.11:01

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signaling pathways activated by microorganisms.
Authors Takeuchi O, Akira S.
Affiliation Department of Host Defense, Research Institute for Microbial Diseases, OsakaUniversity, ERATO, Japan Science and Technology Agency, 3-1 Yamada-oka, Suita,Osaka 565-0871, Japan.
Abstract Invasion of viruses and bacteria is initially sensed by the host innate immunesystem, and evokes a rapid inflammatory response. Nucleotides from RNA virusesare recognized by retinoic-acid-inducible gene I-like helicases and Toll-likereceptors, and this recognition triggers signaling cascades that induceantiviral mediators such as type I interferons. By contrast, Toll-like receptorsrecognizing bacterial components induce the expression of proinflammatorycytokines. Furthermore, recent studies suggest that viral and bacterial DNA alsoinduce interferons in a Toll-independent mechanism, possibly throughunidentified cytoplasmic receptor(s).
PMID 17303405
Model Abstract

Entity

MO000000058:NF-kappaB MO000000065:RIP1 MO000000211:IKK-beta MO000000212:TRAF6 MO000000248:IKK MO000000276:AP-1 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1{active} MO000016599:IKK-gamma MO000016882:LPS MO000016899:FADD MO000016900:Caspase-8 MO000016906:Caspase-10 MO000016963:TRAF3 MO000019005:MKK6 MO000019331:TBK1 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000022136:Ubc13 MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 MO000056638:ATF3 e1: e10: e100:MAP kinase{active} e11:lipoproteins e12:lipoproteins:TLR1 e13:TLR2:peptidoglycan e14:lipoprotein:TLR2 e15:peptidoglycan:TLR6 e16:lipoprotein:TLR6 e17:LPS:TLR4 e18:flagellin:TLR5 e19: e2: e20: e21: e22: e23: e24: e25:ssRNA:TLR7 e26:ssRNA e27:CpG DNA e28:CpGDNA:TLR9 e29:MDA5 e3: e30:dsRNA:MDA5 e31:RIG-I e32:dsRNA:RIG-I e33:IPS1 e34:dsRNA:MDA5:IPS1 e35:dsRNA:RIG-1:IPS1 e36:NF-kappaB{active} e37: e38: e39: e4: e40: e41: e42: e43: e44: e45: e46:dsRNA:RIG1:IPS1:TRAF6 e47:RIG1:IPS1:TRAF6:TBK1 e48:RIG1:IPS1:TRAF6:TBK1{active} e49:IKK-i e5:peptidoglycan e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:peptidoglycan:TLR1 e60: e61: e62: e63:RIG1:IPS1:TRAF6:IKK-i e64:RIG1:IPS1:TRAF6:IKK-i e65:(IRF-3{p})2 e66:(IRF-3{p})2 e67:(IRF-7{p})2 e68:(IRF-7{p})2 e69:IPS1:FADD e7: e70:IPS1:FADD:caspase-8 e71:IPS1:FADD:capase-10 e72:dsRNA:TLR3:TRIF e73:dsRNA:TLR3:TRIF:TRAF3 e74:dsRNA:TLR3:TRIF:TRAF6 e75:dsRNA:TLR3:TRIF:TRAF6:RIP1 e76:IRAK1 e77:MYD88:TRAF3:TRAF6:IKK:IRAK1:IRAK4 e78:CpG:TLR9:MYD88:TRAF3:TRAF6:IKK:IRAK1:IRAK4 e79:LPS:TLR4:TIRAP e8: e80:LPS:TLR4:TIRAP:MYD88 e81:IRAK-4{active} e82:IRAK1{active} e83:TRAF6{active} e84:UVE1A e85:TRAF6:UBC13:UVE1A e86:TRAF6{ub}:UBC13:UVE1A e87:IKK-gamma{ub} e88:TAK1 e89:IKK-beta e9: e90:MKK6 e91:MYD88:IRF5 e92:NF-kappaB{active} e93:AP-1{active} e94:ATF3 e95:LPS:TLR4:TRAM e96:LPS:TLR4:TRIF e97:cytokines e98:type I interferons e99:MAP kinase

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p7 p8 p9
Model Detail
302.0, 1256.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p34 p39

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
418.0, 518.0
36.0, 36.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1159.0, 863.0
34.0, 34.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
529.0, 1205.0
38.0, 38.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p37 p40 p46

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
781.0, 465.0
30.0, 30.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1051.0, 1491.0
34.0, 34.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
316.0, 1472.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p23

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
955.0, 267.0
34.0, 34.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
685.0, 1429.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p27 p40

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
822.0, 590.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p43 p53

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1051.0, 903.0
34.0, 34.0

TAK1{active}

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p51 p52

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1122.0, 822.0
32.0, 32.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1571.0, 743.0
34.0, 34.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
578.0, 1074.0
28.0, 28.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
771.0, 979.0
26.0, 26.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
833.0, 961.0
30.0, 30.0

Caspase-10

--

MO000016906

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m1821

10

false

infinite

0

unit false false false
TRANSPATHMO000016906

--

Go back
506.0, 598.0
28.0, 28.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p40

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1044.0, 360.0
32.0, 32.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p61

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
440.0, 1364.0
32.0, 32.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1276.0, 815.0
40.0, 40.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1276.0, 159.0
48.0, 48.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
1276.0, 383.0
40.0, 40.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
582.0, 850.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1278.0, 945.0
36.0, 36.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1277.0, 596.0
38.0, 38.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
967.0, 975.0
34.0, 34.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
1552.0, 880.0
32.0, 32.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
393.0, 841.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12 p13

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1280.0, 1072.0
40.0, 40.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
920.0, 628.0
32.0, 32.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p44

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
607.0, 727.0
26.0, 26.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p57

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1217.0, 1309.0
30.0, 30.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
597.0, 809.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p35

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
318.0, 1618.0
28.0, 28.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22 p23

p24

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
726.0, 1550.0
36.0, 36.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p27

p29

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
713.0, 809.0
30.0, 30.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
799.0, 815.0
34.0, 34.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
930.0, 1506.0
36.0, 36.0

ATF3

--

MO000056638

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m31885

10

false

infinite

0

unit false false false
TRANSPATHMO000056638

--

Go back
186.75, 104.47190401980379
1162.1098241882048, 1687.3834647212716

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
521.0, 160.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1165.0, 357.54185952908017
46.95914670959952, 28.9581404709197

MAP kinase{active}

--

e100

cso30:c:Protein

cso30:i:CC_Cell

--

p61

p62

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1657.0, 160.99912126537788
46.924428822495614, 30.500878734622148

lipoproteins

--

e11

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2 p4 p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1281.5, 306.8020171015128
29.55229116421837, 57.197982898487176

lipoproteins:TLR1

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1281.5, 446.3150624862967
29.287217715413288, 56.68493751370314

TLR2:peptidoglycan

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1283.5, 522.0898925674193
25.786888840166633, 49.91010743258058

lipoprotein:TLR2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1282.5, 653.1164218373165
26.289848717386537, 50.88357816268363

peptidoglycan:TLR6

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1282.5, 735.9592194694147
27.921069940802454, 54.0407805305854

lipoprotein:TLR6

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1282.5, 871.9592194694147
27.921069940802454, 54.0407805305854

LPS:TLR4

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p42 p55 p56 p57

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1283.5, 998.9055031791277
25.36549002411752, 49.09449682087262

flagellin:TLR5

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
532.0880140587551, 821.1032996390576
400.2553122957284, 110.73730306848466

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
186.75, 104.47190401980379
1162.1098241882048, 1687.3834647212716

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
524.75, 813.7652855803026
414.9313404132381, 125.41333118599478

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
524.75, 813.7652855803026
414.9313404132381, 125.41333118599478

--

e21

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false true false

--

Go back
530.7538296844359, 819.7691152647384
402.9236810443662, 113.40567181712281

--

e22

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false true false

--

Go back
524.75, 813.7652855803026
414.9313404132381, 125.41333118599478

--

e23

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false true false

--

Go back
528.7525531229574, 817.7678387032599
406.9262341673239, 117.40822494008015

--

e24

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false true false

--

Go back
771.5, 800.9971497478624
24.28480596360447, 47.00285025213769

ssRNA:TLR7

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
872.0, 731.4063801797852
48.568296426222325, 25.093619820214865

ssRNA

--

e26

cso30:c:Rna

cso30:i:CC_Cell

--

--

p9

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
745.0, 694.8073496659242
53.4075723830735, 18.692650334075726

CpG DNA

--

e27

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
660.5, 805.0100855075642
23.761455821091864, 45.98991449243588

CpGDNA:TLR9

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p41

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
304.0, 836.2850674179913
39.267458241094786, 24.21493258200845

MDA5

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
209.9921964837641, 127.71410050356798
1115.6254312206772, 1640.8990717537451

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
322.5, 735.9953341109815
26.137143809365107, 32.0046658890185

dsRNA:MDA5

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p15

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
296.0, 893.26
40.31999999999999, 30.24

RIG-I

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
416.0, 974.3093922651933
32.12154696132597, 35.690607734806626

dsRNA:RIG-I

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
466.5, 1042.3010666130006
26.947675588649627, 43.69893338699941

IPS1

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14 p15 p31

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
410.5, 641.6190126628741
26.073040924940354, 36.380987337126086

dsRNA:MDA5:IPS1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
363.5, 1109.8172141677373
25.930996513121674, 36.182785832262795

dsRNA:RIG-1:IPS1

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p17

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
369.0, 1381.0
30.0, 30.0

NF-kappaB{active}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p34 p39

p54

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
508.1709672386893, 1086.2423322932916
8.259270597238936, 14.866687075030056

--

e37

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false true false

--

Go back
511.5552537273137, 1095.8311440110613
1.289251995666565, 1.2892519956665636

--

e38

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false true false

--

Go back
472.54085803432133, 1021.7445631825283
95.40143525740966, 133.21297971918796

--

e39

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false true false

--

Go back
252.99025997872786, 168.38794435015498
1029.6293042307502, 1559.5513840605702

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
484.17517940717624, 1031.7791653666152
72.13279251169999, 113.1437753510134

--

e40

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false true false

--

Go back
472.54085803432133, 1021.7445631825283
95.40143525740966, 133.21297971918796

--

e41

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false true false

--

Go back
472.54085803432133, 1021.7445631825283
95.40143525740966, 133.21297971918796

--

e42

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false true false

--

Go back
472.25, 1021.4537051482066
95.98315132605234, 133.7946957878307

--

e43

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false true false

--

Go back
484.4660374414975, 1032.0700234009369
71.55107644305731, 112.56205928237063

--

e44

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false true false

--

Go back
484.4660374414975, 1032.0700234009369
71.55107644305731, 112.56205928237063

--

e45

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false true false

--

Go back
442.0, 1280.6764705882351
27.794117647058822, 46.32352941176472

dsRNA:RIG1:IPS1:TRAF6

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18 p21

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
505.0, 1431.6176470588232
29.029411764705884, 48.38235294117647

RIG1:IPS1:TRAF6:TBK1

--

e47

cso30:c:Complex

cso30:i:CC_Cell

--

p18

p19

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
534.0, 1506.0
36.0, 60.0

RIG1:IPS1:TRAF6:TBK1{active}

--

e48

cso30:c:Complex

cso30:i:CC_Cell

--

p19

p22 p26

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
596.0, 1321.6791393826002
23.105706267539755, 53.32086061739945

IKK-i

--

e49

cso30:c:Protein

cso30:i:CC_Cell

--

--

p21

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1562.0, 91.0
60.0, 34.0

peptidoglycan

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1 p3 p5

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
739.0, 1053.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
789.2936761946803, 1063.00774093139
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
745.069926437289, 1058.6363602631968
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
745.9370587854731, 1059.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
739.0, 1053.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
739.0, 1053.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
745.9370587854731, 1059.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1078.915880488185, 1226.426469636829
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
1002.6082338479803, 1347.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
739.0, 1053.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1282.5, 228.2880947160711
27.751151063363295, 53.71190528392896

peptidoglycan:TLR1

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
848.7511016961721, 1240.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
848.2586758712023, 1219.489410851356
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
869.4329863449013, 1278.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
590.0, 1380.941176470588
28.23529411764706, 47.05882352941177

RIG1:IPS1:TRAF6:IKK-i

--

e63

cso30:c:Complex

cso30:i:CC_Cell

--

p21

p20

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
638.0, 1547.7647058823527
28.941176470588236, 48.235294117647065

RIG1:IPS1:TRAF6:IKK-i

--

e64

cso30:c:Complex

cso30:i:CC_Cell

--

p20

p23 p27

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
497.0, 1643.7348066298343
29.03867403314917, 32.26519337016574

(IRF-3{p})2

--

e65

cso30:c:Complex

cso30:i:CC_Cell

--

p24

p25

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
785.0, 1346.8011049723757
30.779005524861873, 34.1988950276243

(IRF-3{p})2

--

e66

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p25

p59

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
851.5, 1620.29511748042
25.07565405765705, 30.70488251958006

(IRF-7{p})2

--

e67

cso30:c:Complex

cso30:i:CC_Cell

--

p29

p30

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
869.5, 1397.486085652391
29.81969671721379, 36.513914347608726

(IRF-7{p})2

--

e68

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p30

p60

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
635.5, 1003.7767038826862
32.84902516247292, 40.22329611731379

IPS1:FADD

--

e69

cso30:c:Complex

cso30:i:CC_Cell

--

p31

p32 p33

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
161.33758720127486, 107.0
1181.731852401798, 1674.4835104143556

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
695.5, 1078.3257478436412
24.849880712057264, 34.674252156358975

IPS1:FADD:caspase-8

--

e70

cso30:c:Complex

cso30:i:CC_Cell

--

p32

p16

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
652.5, 1166.4617360983668
31.202422462837216, 43.538263901633336

IPS1:FADD:capase-10

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
530.5, 689.5089007157275
26.151954487061843, 36.49109928427234

dsRNA:TLR3:TRIF

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p36 p37

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
601.0, 483.61764705882354
29.029411764705884, 48.38235294117647

dsRNA:TLR3:TRIF:TRAF3

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
661.0, 551.0
29.999999999999996, 50.0

dsRNA:TLR3:TRIF:TRAF6

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
498.0, 469.0
27.0, 45.0

dsRNA:TLR3:TRIF:TRAF6:RIP1

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
971.0, 579.2597102032602
42.551821292010466, 26.240289796739788

IRAK1

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40 p45

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
931.0, 411.3529411764706
34.588235294117645, 57.64705882352941

MYD88:TRAF3:TRAF6:IKK:IRAK1:IRAK4

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
875.0, 799.6764705882354
33.79411764705882, 56.32352941176471

CpG:TLR9:MYD88:TRAF3:TRAF6:IKK:IRAK1:IRAK4

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1282.5, 1143.790970820334
35.26647091209395, 49.209029179666004

LPS:TLR4:TIRAP

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
207.0, 222.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1286.0, 1216.6470588235293
28.41176470588235, 47.35294117647059

LPS:TLR4:TIRAP:MYD88

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
985.0, 745.0
29.0, 29.0

IRAK-4{active}

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

p45

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1037.0, 497.54185952908017
46.95914670959952, 28.9581404709197

IRAK1{active}

--

e82

cso30:c:Protein

cso30:i:CC_Cell

--

p45

p46

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
641.0, 1253.0
38.0, 38.0

TRAF6{active}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p47 p50

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1052.5, 1010.1618031797143
22.10022137250956, 35.83819682028577

UVE1A

--

e84

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p47

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
989.5, 903.2455496421362
29.924022756469075, 41.754450357863824

TRAF6:UBC13:UVE1A

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48 p49

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1030.5, 789.652046247018
26.049366856303912, 36.3479537529822

TRAF6{ub}:UBC13:UVE1A

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1100.0, 676.0
32.0, 32.0

IKK-gamma{ub}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1115.0, 1023.0
34.0, 34.0

TAK1

--

e88

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1167.0, 979.0
34.0, 34.0

IKK-beta

--

e89

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

p54

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
215.0, 243.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1124.0, 480.0
32.0, 32.0

MKK6

--

e90

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p28

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
875.5, 315.41676387268785
33.14297617063822, 40.58323612731211

MYD88:IRF5

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
785.0, 1289.0
30.0, 30.0

NF-kappaB{active}

--

e92

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

p58

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1199.0, 1491.0
34.0, 34.0

AP-1{active}

--

e93

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m95

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
982.0, 1618.0
36.0, 36.0

ATF3

--

e94

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

--

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
TRANSPATHMO000056638

--

Go back
1281.5, 1350.610754266838
36.82895944209946, 51.389245733162056

LPS:TLR4:TRAM

--

e95

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1287.5, 1448.7199486144248
33.167370159662326, 46.28005138557534

LPS:TLR4:TRIF

--

e96

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
910.0, 1200.0
60.0, 32.0

cytokines

--

e97

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p58 p62

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
998.0, 1328.0
60.0, 32.0

type I interferons

--

e98

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p59 p60

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1013.0, 257.54185952908017
46.95914670959952, 28.9581404709197

MAP kinase

--

e99

cso30:c:Protein

cso30:i:CC_Cell

--

--

p61

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1418.0, 98.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019396 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3963*m5*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR1, TLR2 and TLR6 recognize various bacterial components, including peptidoglycan and lipoproteins.

Go back
722.0, 754.5
19.5, 19.5

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m19828*m27*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR9 recognize single-stranded (ss) RNA and unmethylated DNA with CpG motifs, respectively.

Go back
497.0, 832.5
22.5, 22.5

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR9 recognize single-stranded (ss) RNA and unmethylated DNA with CpG motifs, respectively

Go back
366.0, 790.0
19.0, 19.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 MO000022224

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m29*m119368*0.1

nodelay

--

true

0

false

PMID: 17303405 MDA5 recognizes polyinosinic polycytidylic acid (poly I:C) while RIG-I detects dsRNAs that have been transcribed in vitro.

Go back
420.0, 896.0
23.0, 23.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m119368*m31*0.1

nodelay

--

true

0

false

PMID: 17303405 MDA5 recognizes polyinosinic polycytidylic acid (poly I:C) while RIG-I detects dsRNAs that have been transcribed in vitro.

Go back
364.0, 1052.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 17303405, 16177806, 16125763, 16127453 RIG-I and MDA5 associate with an adaptor protein, interferon-beta promoter stimulator 1 (IPS1)which contains a CARD.

Go back
413.0, 741.0
21.0, 21.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m30*m33*0.1

nodelay

--

true

0

false

PMID: 17303405, 16177806, 16125763, 16127453 RIG-I and MDA5 associate with an adaptor protein, interferon-beta promoter stimulator 1 (IPS1)which contains a CARD.

Go back
374.0, 1233.5
20.5, 20.5

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e70

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m36*m71*0.1

nodelay

--

true

0

false

PMID: 17303405 Overexpression of IPS1 induced the activation of the interferon promoters as well as NF-¦ÊB. PMID: 17303405, 16585540 FADD interacts with Caspase-8/-10 and IPS1, and a FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS1.

Go back
445.0, 1213.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000000212

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m35*m183*0.1

nodelay

--

true

0

false

PMID: 17303405, 16858409 The C-terminal TRAF domain of TRAF3 associates with a TRAF binding domain found in IPS-1.

Go back
507.0, 1291.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e46 MO000019331

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m47*m3902*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF3 recruits and activates two IKK-related kinases, TBK1 (TANK-binding kinase 1) and IKK-i (inducible I¦ÊB kinase, also known as IKK epsilon).

Go back
553.0, 1449.0
21.0, 21.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF3 recruits and activates two IKK-related kinases, TBK1 (TANK-binding kinase 1) and IKK-i (inducible I¦ÊB kinase, also known as IKK epsilon).

Go back
1466.0, 198.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019396 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3963*m11*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR1, TLR2 and TLR6 recognize various bacterial components, including peptidoglycan and lipoproteins.

Go back
643.0, 1454.5
18.5, 18.5

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF3 recruits and activates two IKK-related kinases, TBK1 (TANK-binding kinase 1) and IKK-i (inducible I¦ÊB kinase, also known as IKK epsilon).

Go back
549.0, 1337.0
21.0, 21.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e49 e46

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m63*m47*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF3 recruits and activates two IKK-related kinases, TBK1 (TANK-binding kinase 1) and IKK-i (inducible I¦ÊB kinase, also known as IKK epsilon).

Go back
320.0, 1544.0
23.0, 23.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000007694 e48

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c64 : 1
stoichiometry:c63 : 1

m977*m49*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
386.0, 1574.0
19.0, 19.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000007694 e64

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m977*m65*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
412.0, 1648.0
23.0, 23.0

p24

p24

cso30:i:ME_Dimerization

cso30:i:CC_Cell

--

MO000041456

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
625.0, 1645.0
21.0, 21.0

p25

p25

cso30:i:ME_Translocation

cso30:i:CC_Cell

--

e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
702.0, 1502.0
19.0, 19.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000007702 e48

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m980*m49*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
760.0, 1499.5
19.5, 19.5

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cell

--

MO000007702 e64

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m980*m65*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
1132.0, 1496.0
23.0, 23.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000000276 e90

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1

m219*m92*0.1

nodelay

--

true

0

false

PMID: 17303405 TAK1 also activates MAP kinases, leading to the activation of AP-1, which is also critical for the induction of cytokine genes.

Go back
749.0, 1625.0
21.0, 21.0

p29

p29

cso30:i:ME_Dimerization

cso30:i:CC_Cell

--

MO000041457

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
1472.0, 308.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e5

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3964*m5*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR1, TLR2 and TLR6 recognize various bacterial components, including peptidoglycan and lipoproteins.

Go back
853.0, 1553.0
21.0, 21.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_Cell

--

e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17303405, 15800576 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons and a set of interferon-inducible genes.

Go back
580.0, 1012.0
23.0, 23.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 MO000016899

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m33*m1814*0.1

nodelay

--

true

0

false

PMID: 17303405, 16585540 FADD interacts with Caspase-8/-10 and IPS1, and a FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS1.

Go back
698.0, 1002.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e69 MO000016900

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m70*m1815*0.1

nodelay

--

true

0

false

PMID: 17303405, 16585540 FADD interacts with Caspase-8/-10 and IPS1, and a FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS1.

Go back
757.0, 1033.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e69 MO000016906

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m70*m1821*0.1

nodelay

--

true

0

false

PMID: 17303405, 16585540 FADD interacts with Caspase-8/-10 and IPS1, and a FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS1.

Go back
320.0, 1324.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e71

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m36*m72*0.1

nodelay

--

true

0

false

PMID: 17303405, 16585540 FADD interacts with Caspase-8/-10 and IPS1, and a FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS1.

Go back
532.0, 763.5
19.5, 19.5

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17303405 Upon stimulation with poly I:C, TLR3 triggers a signaling cascade via TRIF.

Go back
610.0, 630.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000016963

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m73*m1872*0.1

nodelay

--

true

0

false

PMID: 17303405 Downstream of TRIF are the signaling molecules TRAF3, TRAF6 and receptor-interacting protein-1 (RIP1).

Go back
665.0, 645.0
21.0, 21.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000000212

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m73*m183*0.1

nodelay

--

true

0

false

PMID: 17303405 Downstream of TRIF are the signaling molecules TRAF3, TRAF6 and receptor-interacting protein-1 (RIP1).

Go back
502.0, 566.0
19.0, 19.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m76*m75*0.1

nodelay

--

true

0

false

Go back
289.0, 1385.5
21.5, 21.5

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e75

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m36*m77*0.1

nodelay

--

true

0

false

PMID: 17303405, 16306936, 16306937 Among these, TRAF6 and RIP1 activate NF-¦ÊB, whereas TRAF3 is responsible for inducing type I interferons.

Go back
1461.0, 389.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 MO000019397

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c10 : 1

m11*m3964*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR1, TLR2 and TLR6 recognize various bacterial components, including peptidoglycan and lipoproteins.

Go back
885.0, 537.0
30.0, 30.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000039077 e76 MO000016963 MO000000212 MO000007702 MO000000248

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m1572*m17258*m78*m1872*m183*m980*m207*0.1

nodelay

--

true

0

false

PMID: 17303405, 16306936, 16306937, 15361868, 15492225, 15767370, 16612387 Upon exposure to ssRNA and CpG-DNA, MyD88 forms a complex with IL-1R-associated kinase (IRAK)-4, IRAK-1, TRAF3, TRAF6, IKK-alpha and IRF-7, and this complex is recruited to the TLR

Go back
726.0, 430.0
19.0, 19.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e77 e28

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m79*m28*0.1

nodelay

--

true

0

false

PMID: 17303405, 16306936, 16306937, 15361868, 15492225, 15767370, 16612387 Upon exposure to ssRNA and CpG-DNA, MyD88 forms a complex with IL-1R-associated kinase (IRAK)-4, IRAK-1, TRAF3, TRAF6, IKK-alpha and IRF-7, and this complex is recruited to the TLR

Go back
1440.0, 1032.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022528 e17

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m6810*m17*0.1

nodelay

--

true

0

false

PMID: 17303405 In TLR2 and TLR4 signaling, another adaptor, TIRAP (TIR domain-containing adaptor protein), is required for the recruitment of MyD88 to TLRs.

Go back
1152.0, 1088.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000016573 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m1572*m81*0.1

nodelay

--

true

0

false

PMID: 17303405 In TLR2 and TLR4 signaling, another adaptor, TIRAP (TIR domain-containing adaptor protein), is required for the recruitment of MyD88 to TLRs.

Go back
990.0, 678.0
19.0, 19.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000039077 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m17258*m82*0.1

nodelay

--

true

0

false

PMID: 17303405 MyD88 triggers sequential activation of IRAK-4, IRAK-1 and TRAF6.

Go back
1048.0, 580.0
23.0, 23.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1

m78*m83*0.1

nodelay

--

true

0

false

PMID: 17303405 MyD88 triggers sequential activation of IRAK-4, IRAK-1 and TRAF6.

Go back
572.0, 1260.0
23.0, 23.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c134 : 1
stoichiometry:c133 : 1

m183*m84*0.1

nodelay

--

true

0

false

PMID: 17303405 MyD88 triggers sequential activation of IRAK-4, IRAK-1 and TRAF6.

Go back
852.0, 1016.0
23.0, 23.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000022136 e84 e83

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m6443*m86*m85*0.1

nodelay

--

true

0

false

PMID: 17303405, 16056267 Together with an ubiquitination E2 enzyme complex consisting of UBC13 and UEV1A, TRAF6 catalyzes the formation of a K63-linked polyubiquitin chain on itself and on IKK-¦Ã/NF-¦ÊB essential modulator (NEMO).

Go back
969.0, 857.0
21.0, 21.0

p48

p48

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 17303405, 16056267 Together with an ubiquitination E2 enzyme complex consisting of UBC13 and UEV1A, TRAF6 catalyzes the formation of a K63-linked polyubiquitin chain on itself and on IKK-¦Ã/NF-¦ÊB essential modulator (NEMO).

Go back
1112.0, 756.0
23.0, 23.0

p49

p49

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016599 e85

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c142 : 1

m1593*m87*0.1

nodelay

--

true

0

false

PMID: 17303405, 16056267 Together with an ubiquitination E2 enzyme complex consisting of UBC13 and UEV1A, TRAF6 catalyzes the formation of a K63-linked polyubiquitin chain on itself and on IKK-¦Ã/NF-¦ÊB essential modulator (NEMO).

Go back
1574.0, 525.5
20.5, 20.5

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019422 e5

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3987*m5*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR1, TLR2 and TLR6 recognize various bacterial components, including peptidoglycan and lipoproteins.

Go back
1084.0, 964.0
23.0, 23.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e88 e83

MO000016574

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c145 : 1

m90*m85*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF6 also activates TGF-¦Â-activated kinase 1 (TAK1), which phosphorylates IKK-¦Â and MAP kinase kinase 6.

Go back
1167.0, 931.5
20.5, 20.5

p51

p51

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000000211 MO000016574

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m182*m1573*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF6 also activates TGF-¦Â-activated kinase 1 (TAK1), which phosphorylates IKK-¦Â and MAP kinase kinase 6.

Go back
1093.0, 413.0
21.0, 21.0

p52

p52

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e90 MO000016574

MO000019005

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m92*m1573*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF6 also activates TGF-¦Â-activated kinase 1 (TAK1), which phosphorylates IKK-¦Â and MAP kinase kinase 6.

Go back
962.0, 326.0
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007700 MO000016573

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m979*m1572*0.1

nodelay

--

true

0

false

PMID: 17303405, 15665823 It was shown that IRF-5 associates with MyD88, and regulates the expression of cytokine genes, but not interferon genes, in response to stimulation with TLR ligands.

Go back
411.0, 1467.0
25.0, 25.0

p54

p54

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e36 e89

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c158 : 1
stoichiometry:c157 : 1

m37*m91*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF6- and UBC13-mediated ubiquitination activates the TAK1 complex, resulting in the activation of the IKK complex and nuclear translocation of NF-¦ÊB that initiates the expression of proinflammatory cytokine genes.

Go back
963.0, 1571.5
17.5, 17.5

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

MO000056638 e17

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c163 : 1

m31885*m17*0.1

nodelay

--

true

0

false

PMID: 17303405, 16688168 On the other hand, activating transcription factor 3 (ATF3) is also rapidly induced in response to LPS, and has been identified as a negative regulator of LPS-induced cytokine gene expression.

Go back
1417.0, 1313.0
21.0, 21.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041132 e17

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m19005*m17*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR4 also recruits other TIR containing adaptors, TRAM and TRIF.

Go back
1389.0, 1417.0
21.0, 21.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000041125

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c168 : 1

m17*m18998*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR4 also recruits other TIR containing adaptors, TRAM and TRIF.

Go back
853.0, 1241.0
30.0, 30.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e92

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17303405 NF-kB that initiates the expression of proinflammatory cytokine genes

Go back
929.0, 1333.0
30.0, 30.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e66

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17303405 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons

Go back
1494.0, 674.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019422 e11

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m3987*m11*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR1, TLR2 and TLR6 recognize various bacterial components, including peptidoglycan and lipoproteins.

Go back
945.0, 1381.0
30.0, 30.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17303405 Phosphorylation of IRF-3/-7 by these kinases induces formation of homodimers, which then translocate into the nucleus and bind to the ISREs, resulting in the expression of type I interferons

Go back
1103.0, 297.0
30.0, 30.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e99 MO000019005

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c179 : 1
stoichiometry:c178 : 1

m101*m3613*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF6 also activates TGF-b-activated kinase 1 (TAK1), which phosphorylates IKK-b and MAP kinase kinase 6; these in turn modulate the activation of NF-kB and MAP kinases, which induce genes involved in inflammatory responses.

Go back
997.0, 1169.0
30.0, 30.0

p58

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e100

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 17303405 TRAF6 also activates TGF-b-activated kinase 1 (TAK1), which phosphorylates IKK-b and MAP kinase kinase 6; these in turn modulate the activation of NF-kB and MAP kinases, which induce genes involved in inflammatory responses.

Go back
1481.0, 749.5
21.5, 21.5

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000016882

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR4 and TLR5 are responsible for the recognition of bacterial lipopolysaccharide (LPS) and flagellin, respectively.

Go back
1428.0, 884.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c22 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR4 and TLR5 are responsible for the recognition of bacterial lipopolysaccharide (LPS) and flagellin, respectively.

Go back
785.0, 733.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e26

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19940*m26*0.1

nodelay

--

true

0

false

PMID: 17303405 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR9 recognize single-stranded (ss) RNA and unmethylated DNA with CpG motifs, respectively.

Go back
1324.0, 118.0400991505921

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.1391439360493, 409.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0, 662.959256118263

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 673.8026240265929

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 609.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.0, 546.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 576.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 522.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.10918275627523, 1286.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
311.0, 1396.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
303.8308212832871, 514.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
850.0, 569.1041429180026

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1487.4606604324094, 192.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.9289944709163, 574.4445276135791

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.3531602401445, 562.1513543886333

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 555.2604125941726

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 574.0875218290191

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.0, 574.8047810845554

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.0, 490.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 476.3587460644701

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.0, 440.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 456.89234646700993

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 449.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1316.0, 400.16548182694186

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1320.0, 1050.4151336375553

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1310.0, 912.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1324.1871368396817, 1054.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 618.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1182.1554175279994, 1108.5777087639997

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1175.0, 1111.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
952.0, 655.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 697.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.8137500841101, 704.0324469636073

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1014.0, 592.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.0, 541.1150198852754

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 534.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1005.0, 610.529124941243

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
562.0, 1243.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.0, 1272.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.2416527094628, 526.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
882.6533910434308, 997.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0, 1028.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 1045.1363583827858

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 939.7551284886705

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
987.2219089141281, 885.3225202593821

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1584.159569245789, 125.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.0, 826.4381173212795

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1127.6389052329816, 786.830325002023

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1118.8288486740757, 715.9569472711262

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1019.0, 785.3202590044648

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1105.885143449429, 993.9932582089723

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.4705249501833, 944.2080133580728

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 988.4940092724321

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1176.0, 897.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.0, 952.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1085.0, 923.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1316.1608137520136, 541.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.5777087639997, 441.1554175279993

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.367306591753, 397.9322862329902

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1069.0, 441.97906059045937

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
972.0, 301.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 352.13785166606954

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 336.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.0, 1411.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 1314.3853575413964

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.75005224292914, 1007.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.0, 1508.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.0, 621.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1155.0, 1508.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1140.0, 512.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
956.0, 1542.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0, 1589.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.4338233596853, 926.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1247.0, 1324.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1304.0, 926.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1325.4174343087948, 1329.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1328.2792613278382, 1433.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1301.0, 926.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1317.4771886210588, 688.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.0, 751.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 1350.8448072991666

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
899.0, 1402.019375177176

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.0, 1345.4097180157853

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
975.0, 1364.8

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
815.0, 1270.6336570575136

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
883.0, 1235.8646187432907

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1060.0, 284.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.0, 325.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1074.0, 332.91952058716754

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1509.6330275109124, 192.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.6973645007646, 386.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.3104923889621, 1190.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1316.0, 766.853612525057

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1445.0, 108.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1511.0, 760.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1316.5304467246995, 768.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1314.9987028429207, 907.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1314.0, 905.3726292832431

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1459.0, 896.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.7895392857511, 761.7972783164867

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.0, 744.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.1784904247103, 754.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 781.9869706753918

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.5116931692603, 714.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.3570969743776, 117.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.5137101279801, 774.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 845.9658558131846

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.8035280165417, 848.7620869714772

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 828.5296867331132

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.0, 814.4513482233507

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.9220899170605, 815.9726042969965

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.09505157597033, 773.1676940130167

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 871.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 908.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 919.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1324.0, 186.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
389.94257241545523, 1010.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 1064.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.0, 1075.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.0, 752.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.40632510786924, 769.8754206040678

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 686.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 1251.0015420618654

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 1254.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.28127403907274, 1102.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
389.0, 1144.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1492.9032182291517, 180.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 1224.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 1234.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.0, 1304.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 1322.145770236779

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 1316.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 1457.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.3151918984429, 1470.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
578.0, 1348.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 1310.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 1358.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1317.5439228701434, 215.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.0, 1422.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 1473.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 1504.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.0, 1567.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.96849930882235, 1538.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
343.0, 1504.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.4, 1591.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.9910996253228, 1573.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
346.0, 1636.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.0, 1660.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1316.0, 328.2360481182216

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.0, 1656.3229688096262

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
642.0, 1387.9782444208058

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
703.0, 1459.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
717.0, 1521.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 1514.198443035424

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
715.0, 1458.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.2926937794119, 1519.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 1517.7882796723043

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 1586.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 1636.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1493.6243987850064, 125.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 1582.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
866.0, 1441.9286546051796

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 1030.685203256719

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 1043.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 1024.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 1015.5689290811055

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.7081432770395, 995.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
708.0, 1021.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 1027.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0818515773648, 989.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1317.1676940130167, 330.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.5719500300767, 1054.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.0, 1286.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.0, 1347.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.3260006262454, 1195.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.4512399668456, 784.7309093090201

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.3806390171605, 746.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 733.9972313548228

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0, 654.3702354610118

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 616.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.2447832916628, 539.9962541943164

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back