1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17336545.csml convertedTime:2009.07.01.11:01

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Viral recognition by Toll-like receptors.
Authors Barton GM.
Affiliation Division of Immunology, Department of Molecular & Cell Biology, University ofCalifornia, Berkeley, CA 94720-3200, United States. barton@berkeley.edu
Abstract Toll-like receptors (TLRs) have evolved to recognize conserved features ofmicrobial pathogens, including bacteria, viruses, fungi, and protozoa. Amongthese pathogen classes, viruses are particularly vexing, as they generally lackany uniquely foreign features that easily distinguish them from the host.Consequently, a number of TLR family members have evolved to recognize variousforms of viral nucleic acid. The emergence of this specificity has interestingimplications for how we view the evolution of viral genomes. In this review, Idiscuss the various strategies used by TLRs to recognize viruses as well as theexperimental evidence implicating TLRs in viral immunity.
PMID 17336545
Model Abstract

Entity

MO000000058:NF-kappaB MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000022224:dsRNA MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 e1: e10:ssRNA e11: e12:TLR7:ssRNA e13:TLR8:ssRNA e14:Viral protein e15:TLR4:viral protein e16:TLR2:viral protein e17:NF-kappaB{active} e18:IRF-3{active} e19:TLR7:ssRNA:MyD88 e2: e20:TLR8:ssRNA:MyD88 e21:TLR9:ssRNA:MyD88 e22:IRF-7{active} e23:Type I IFNs e3: e4: e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e7:CpG DNA e8: e9:TLR9:CpGDNA

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p3 p4 p5 p6 p7 p8 p9
Model Detail
293.0, 617.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p13 p14 p15

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
685.0, 697.0
22.0, 22.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
401.0, 841.0
22.0, 22.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17 p18

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
546.0, 194.0
20.0, 20.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11 p12

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
313.0, 137.0
22.0, 22.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
213.0, 189.0
21.0, 21.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
827.0, 323.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1057.0, 237.0
22.0, 22.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
554.0, 562.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
725.0, 517.0
22.0, 22.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p8 p9

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
738.0, 310.0
20.0, 20.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p7

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
861.0, 137.0
22.0, 22.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
906.0, 458.0
20.0, 20.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
598.0, 138.0
20.0, 20.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
194.80718040271157, 114.07828493854828
850.9620492815882, 1235.5968955568644

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
678.0, 38.5
60.0, 19.0

ssRNA

--

e10

cso30:c:Dna

cso30:i:CC_Cell_WithoutCellWall_

--

--

p3 p4

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
712.0, 298.0
223.22503934917393, 372.67231145582434

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
677.5, 123.0
21.844770883578164, 42.28020171015128

TLR7:ssRNA

--

e12

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p3

p10

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
769.5, 111.0
21.844770883578164, 42.28020171015128

TLR8:ssRNA

--

e13

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p4

p11

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
272.0, 72.5
23.485610786878645, 14.482793318575165

Viral protein

--

e14

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p5 p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
401.5, 116.0
21.165095373821533, 40.964700723525546

TLR4:viral protein

--

e15

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p5

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
253.5, 124.0
21.165095373821533, 40.964700723525546

TLR2:viral protein

--

e16

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
381.0, 761.0
22.0, 22.0

NF-kappaB{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p13 p14 p15

p19

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
593.0, 761.0
22.0, 22.0

IRF-3{active}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p20

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
549.5, 141.0
21.37768397871169, 29.82932648192328

TLR7:ssRNA:MyD88

--

e19

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p10

p13 p16

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
194.80718040271157, 114.07828493854828
850.9620492815882, 1235.5968955568644

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
997.5, 141.0
21.37768397871169, 29.82932648192328

TLR8:ssRNA:MyD88

--

e20

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p11

p14 p17

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
737.5, 369.0
21.37768397871169, 29.82932648192328

TLR9:ssRNA:MyD88

--

e21

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p12

p15 p18

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
695.0, 795.0
26.0, 26.0

IRF-7{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p17 p18

p21

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
598.0, 1046.0
51.90311418685121, 27.68166089965398

Type I IFNs

--

e23

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19 p20 p21

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
211.82642138834325, 131.09752592418005
816.9235673103249, 1201.558413585603

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
243.31201721176214, 160.88119764903553
753.9523756634868, 1141.9910701358906

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
712.0, 298.0
223.22503934917393, 372.67231145582434

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
469.53925994869087, 886.2672257320801
218.82512167899472, 328.9345778104634

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
433.99760005815364, 882.754042752045
364.4762377010009, 330.32836839440597

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
434.6944953501249, 883.4509380440167
363.08244711705805, 328.9345778104634

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
434.6944953501249, 883.4509380440167
363.08244711705805, 328.9345778104634

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
702.3022874671117, 1017.6032817484966
23.380007357862496, 21.165059292380818

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
640.9755017736361, 1115.1686226244806
66.20505273727545, 59.93299510953357

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
712.0, 298.0
223.22503934917393, 372.67231145582434

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
517.323891662056, 1029.045449363291
11.851402005248033, 5.706230595119427

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
516.9281398027406, 1012.0281194127249
40.56456557984007, 73.01621804371213

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
533.9454697533079, 1059.518342530587
6.332029749048204, 6.332029749048199

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1058.0, 445.5
60.0, 13.0

CpG DNA

--

e7

cso30:c:Dna

cso30:i:CC_Cell_WithoutCellWall_

--

--

p2

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
203.96335359956785, 157.09330846202485
791.3467744400882, 1149.035516487007

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
721.5, 423.0
21.844770883578164, 42.28020171015128

TLR9:CpGDNA

--

e9

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p2

p12

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
826.0, 238.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17336545,11607032,11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA),TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
618.0, 234.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e12 MO000016573

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
762.0, 194.0
19.0, 19.0

p10

p11

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000016573 e13

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m1572*m13*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
566.0, 374.0
19.0, 19.0

p10

p12

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000016573 e9

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m1572*m9*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
322.0, 446.0
19.0, 19.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e19 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m20*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
466.0, 370.0
19.0, 19.0

p13

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e20 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m21*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
478.0, 442.0
22.0, 22.0

p13

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e21 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m22*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
486.0, 798.0
20.0, 20.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e19 MO000007702

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m20*m980*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
550.0, 458.0
20.0, 20.0

p16

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e20 MO000007702

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m21*m980*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
630.0, 538.0
20.0, 20.0

p16

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e21 MO000007702

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m22*m980*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
525.0, 953.0
21.0, 21.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17334565 Both pathways are capable of inducing type I IFNs, but the MyD88-IRF7 pathway appears to function only in pDCs while the Trif pathway appears to function in all cell types.

Go back
930.0, 346.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e7 MO000042012

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m7*m19828*0.1

nodelay

--

true

0

false

PMID: 17336545,11607032,11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA),TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
601.0, 933.0
21.0, 21.0

p19

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 17334565 Both pathways are capable of inducing type I IFNs, but the MyD88-IRF7 pathway appears to function only in pDCs while the Trif pathway appears to function in all cell types.

Go back
673.0, 937.0
21.0, 21.0

p19

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 17334565 Both pathways are capable of inducing type I IFNs, but the MyD88-IRF7 pathway appears to function only in pDCs while the Trif pathway appears to function in all cell types.

Go back
597.0, 65.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e10 MO000042126

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m10*m19940*0.1

nodelay

--

true

0

false

PMID: 17336545, 11607032, 11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA), TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
821.0, 73.0
21.0, 21.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000042007 e10

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19823*m10*0.1

nodelay

--

true

0

false

PMID: 17336545, 11607032, 11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA), TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
350.0, 70.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e14 MO000019394

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m14*m3961*0.1

nodelay

--

true

0

false

PMID: 17336545 Table 1

Go back
178.0, 70.0
19.0, 19.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e14 MO000019397

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m14*m3964*0.1

nodelay

--

true

0

false

PMID: 17336545 Table 1

Go back
601.0, 485.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17336545 TLR3 uses the adaptor Trif to activate the transcription factors NF-kappaB and IRF3.

Go back
536.0, 644.0
23.0, 23.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000041437 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19305*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 TLR3 uses the adaptor Trif to activate the transcription factors NF-kappaB and IRF3.

Go back
592.0, 664.0
23.0, 23.0

p8

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000041437 MO000007694

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19305*m977*0.1

nodelay

--

true

0

false

PMID: 17336545 TLR3 uses the adaptor Trif to activate the transcription factors NF-kappaB and IRF3.

Go back
836.0, 265.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.2541450602852, 100.77511991082454

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 57.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.9463531699773, 94.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.0, 80.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.0, 96.09531267333584

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 89.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.0, 80.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.29878308453075, 96.66261028176922

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 87.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.8973855439314, 330.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 248.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.0, 512.7294278030124

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.0, 499.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.6131882737792, 535.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
315.0, 629.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.4173283056703, 665.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.3119397250665, 539.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.5675675675676, 682.5945945945946

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 687.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.1716000756318, 162.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 209.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.1754418849364, 256.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.8632840217354, 176.35204443655223

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 204.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.9684350024883, 153.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 159.58976840766354

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0, 214.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.4611360597601, 389.8864248990313

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.0, 384.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.8441746598661, 170.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
306.0, 472.8939406483124

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 465.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.7039846776598, 366.3653853714995

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.37308300110453, 160.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.0, 395.5754603881327

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.68197558932377, 389.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.7336418228921, 387.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
315.0, 468.51279923897675

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.34363635420743, 464.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.78722919489917, 171.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
423.0, 816.7120559573644

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0, 808.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.5653651303617, 163.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 372.8211864903555

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 485.4641118913987

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 478.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.381886291202, 399.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 564.4027139079626

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.0, 558.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 783.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.0, 974.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 783.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 954.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.3592553320611, 821.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.3693687140673, 360.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.7688672693959, 958.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.6970138105231, 56.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 94.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 84.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back