1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17349209.csml convertedTime:2009.07.01.11:02

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Nuclear factor-kappaB: activation and regulation during toll-like receptorsignaling.
Authors Carmody RJ, Chen YH.
Affiliation Department of Pathology and Laboratory Medicine, School of Medicine, Universityof Pennsylvania, Philadelphia, PA 19104, USA. rcarmody@mail.med.upenn.edu
Abstract Toll-like receptors (TLRs) recognize distinct microbial components to initiatethe innate and adaptive immune responses. TLR activation culminates in theexpression of appropriate pro-inflammatory and immunomodulatory factors to meetpathogenic challenges. The transcription factor NF-kappaB is the masterregulator of all TLR-induced responses and its activation is the pivotal eventin TLR-mediated activation of the innate immune response. Many of the keymolecular events required for TLR-induced NF-kappaB activation have beenelucidated. However, much remains to be learned about the ability of TLRs togenerate pathogen-specific responses using a limited number of transcriptionfactors. This review will focus on our current understanding of NF-kappaBactivation by TLRs and potential mechanisms for achieving a signal-specificresponse through NF-kappaB.
PMID 17349209
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 MO000000022:p38 MO000000023:JNK MO000000059:SRF MO000000065:RIP1 MO000000192:c-Rel MO000000193:RelA-p65 MO000000196:p52 MO000000199:p105 MO000000200:p50 MO000000202:p100 MO000000205:TNFR MO000000208:RIP MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000214:IL-1 MO000000233:IkappaB-alpha MO000000234:IkappaB-beta MO000000237:IkappaB-epsilon MO000000238:Bcl-3 MO000000248:IKK MO000000276:AP-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000007694:IRF-3 MO000013130:STAT6 MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016591:A20 MO000016599:IKK-gamma MO000016636:(p50)2 MO000017265:IL-12 MO000017462:CBP MO000019394:TLR4 MO000019398:TLR3 MO000019406:Tollip MO000019416:C/EBP MO000019479:protein remnants MO000019984:p300 MO000022125:TAB2 MO000022528:TIRAP MO000030934:ATM MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041541:TAB3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042409:LPS e1: e10: e100:TNF-alpha:TNFR:RIP1{ub} e101:TNF-alpha:TNFR:RIP1{ub}:IKK-gamma e102:TLR3:TRIF:RIP1{ub} e103:IRF-3{active} e104:RelA-p65{p} e105:PKA{active} e106:PKA e107:RelA-p65{p}:p300 e108:RelA-p65:CBP e109:RelA-p65{ace} e11:IkappaB{p}-NF-kappaB e111:p50{ace} e112:IkappaB-alpha e113:IkappaB-alpha:p65 e114:IkappaB-alpha:p65 e115:IRF-3{active} e116:AP-1{active} e117:NF-kappaB:AP1 e118:c/ebp:F-kappaB e119:SP1 e12:IkappaB{p}{ub}:NF-kappaB e120:NF-kappaB:SP1 e121:NF-kappaB:SRF e122:NF-kappaB:STAT6 e123:NF-kappaB:SEF e124:SEF e125:NF-kappaB:DNA:IRF3 e126:IL-12 e127:IkappaB e128:IkappaB e129:IkappaB e13:NF-kappaB e130:NF-kappaB:IkappaB e132:DNA:NF-kappaB{ub} e133:protein remnants e134:c-Rel{p} e135:LPS:TLR4:Tollip e136:TLR2 ligand:TLR2:TLR6:Tollip e137:TLR4:TRAM:TRIF e138:TLR3:TRIF:RIP1{ub}:TAB2:TAB3:TAK1 e14:NF-kappaB e15:DNA e16:DNA:NF-kappaB e17:gene e18:A20:IKK-gamma e19:IKK-gamma:RIP e2: e20:IKK-gamma{p} e21:TNF-alpha:TNFR e22:IL1:IL1R e23:IL-1R e24:IKK-gamma{ub}{sumo}:ATM e25:IKK-gamma{sumo} e26:IKK-gamma{sumo} e27:IKK-gamma{sumo}:ATM e28:IKK-gamma{ub}{sumo}:ATM e29:NF-kappaB{active} e3: e30:NF-kappaB:c-Rel e31:IkappaB-alpha:C-Rel:NF-kappaB e32:IkappaB-beta:C-Rel:NF-kappaB e33:p65:NF-kappaB e34:IkappaB-alpha:p65:NF-kappaB e35:IkappaB-beta:p65:NF-kappaB e36:C-Rel: p65 e37:IkappaB-epsilon:C-Rel:p65 e38:Bcl-3:(p50)2 e39:Bcl-3:(p52)2 e4: e40:(p52)2 e41:IkappaB-zeta e42:(p50)2:IkappaB-zeta e43:p50:p65 e44:p50:p65:IkappaB-zeta e45:LPS:TLR4:TIRAP:MYD88 e46:TLR3 ligand e47:TLR3 ligand:TLR3 e48:TLR3 ligand: TLR3: TRIF e49:LPS:TLR4:TRAM:TRIF e5:IKK e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IkappaB-NF-kappaB e60: e61: e62: e63:LPS:TLR4:TRAM e64:TLR1:TLR2 e65:TLR2 ligand e66:TLR2 ligand:TLR1:TLR2 e67:TLR1:TLR2:TIRAP e68:TLR1:TLR2:TIRAP:MYD88 e69:TLR2:TLR6 e7:LPS:TLR4 e70:TLR2ligand:TLR2:TLR6 e71:TLR2 ligand:TLR2:TLR6:TIRAP e72:TLR2 ligand: TLR2:TLR6: TIRAP:MYD88 e73:TLR7 ligand e74:TLR7 ligand: TLR7 e75:TLR7 ligand:TLR7:MYD88 e76:e76 e77:TLR8 ligand e78:TLR8 ligand:TLR8:MYD88 e79:TLR9 ligand: TLR9 e8:LPS:TLR4:TIRAP e80:TLR9 ligand e81:TLR9 ligand:TLR9:MYD88 e82:LPS:TLR4:TIRAP:MYD88:IRAK-4 e83:IRAK1 e84:LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1{p} e85:LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1 e86:LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1{p}:TRAF6 e87:LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1{p}{ub}:TRAF6 e88:LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6 e89:LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub} e9: e90:UBC13:Uev1A e91:LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub}:TAB1:TAB2:TAB3 e92:LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub}:TAB1:TAB2:TAB3:TAK1 e93:LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub}:TAB1:TAB2:TAB3:TAK1{active} e94:JNK{active} e95:p38 e96:AP-1{active} e97:TLR3 ligand:TLR3:TRIF RIP1 e98:LPS:TLR4:TRAM:TRIF:RIP1 e99:TNF-alpha:TNFR:RIP1

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
1045.0, 1347.0
40.0, 40.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p72

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
918.0, 1540.0
38.0, 38.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p89

p90

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
1101.0, 823.0
32.0, 32.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1019.0, 635.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
611.0, 1485.0
28.0, 28.0

SRF

--

MO000000059

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m125

10

false

infinite

0

unit false false false
InterProIPR005829
TRANSPATHMO000000059

--

Go back
614.0, 236.0
30.0, 30.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65 p66 p67

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1013.0, 1187.0
32.0, 32.0

c-Rel

--

MO000000192

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p102

true true true true

csml-variable:Double

m165

10

false

infinite

0

unit false false false
TRANSPATHMO000000192

--

Go back
992.0, 1358.0
25.0, 25.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73 p77 p78 p79 p100

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
548.0, 420.0
30.0, 30.0

p52

--

MO000000196

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m168

10

false

infinite

0

unit false false false
TRANSPATHMO000000196

--

Go back
628.0, 374.0
34.0, 34.0

p105

--

MO000000199

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
797.0, 375.0
32.0, 32.0

p50

--

MO000000200

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p80

true true true true

csml-variable:Double

m172

10

false

infinite

0

unit false false false
TRANSPATHMO000000200

--

Go back
488.0, 356.0
30.0, 30.0

p100

--

MO000000202

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m173

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
1383.0, 1144.0
28.0, 28.0

TNFR

--

MO000000205

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m176

10

false

infinite

0

unit false false false
TRANSPATHMO000000205

--

Go back
403.0, 565.0
28.0, 28.0

RIP

--

MO000000208

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m179

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000208

--

Go back
400.0, 762.0
26.0, 26.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p100 p102

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
458.0, 612.0
30.0, 30.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p13 p16 p77

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
1314.0, 636.0
22.0, 22.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1497.0, 1330.0
32.0, 32.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
889.0, 935.0
23.0, 23.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p26

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
985.0, 1011.0
24.0, 24.0

IkappaB-beta

--

MO000000234

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p27

true true true true

csml-variable:Double

m200

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000234

--

Go back
1174.0, 1401.0
24.0, 24.0

IkappaB-epsilon

--

MO000000237

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m203

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000237

--

Go back
699.0, 1373.0
20.0, 20.0

Bcl-3

--

MO000000238

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30

true true true true

csml-variable:Double

m204

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000238

--

Go back
439.0, 869.0
28.0, 28.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p3 p22

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1151.0, 1129.0
28.0, 28.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1514.0, 1147.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1194.0, 1592.0
38.0, 38.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p90

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
955.0, 385.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
745.0, 1271.0
32.0, 32.0

STAT6

--

MO000013130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m1368

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013130

--

Go back
1040.0, 238.0
26.0, 26.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p42 p45 p47 p49 p51

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1299.0, 981.0
27.0, 27.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60 p110

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1296.0, 850.0
26.0, 26.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
543.0, 671.0
34.0, 34.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p106 p70 p109

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
604.0, 638.0
34.0, 34.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11 p12 p13 p16 p18 p69

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
784.0, 1284.0
24.0, 24.0

(p50)2

--

MO000016636

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p31

true true true true

csml-variable:Double

m1621

10

false

infinite

0

unit false false false
TRANSPATHMO000016636

--

Go back
1134.0, 1664.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p92

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
761.0, 1507.0
32.0, 32.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
1187.0, 165.0
36.0, 36.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
861.0, 159.0
40.0, 40.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1026.0, 360.0
38.0, 38.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p104 p105

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
498.0, 1364.0
30.0, 30.0

C/EBP

--

MO000019416

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m3981

10

false

infinite

0

unit false false false
TRANSPATHMO000019416

--

Go back
559.0, 803.0
34.0, 34.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p57 p107

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1042.0, 1436.0
30.0, 30.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
1277.0, 911.0
32.0, 32.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p110

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
1212.0, 222.0
26.0, 26.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p41 p44

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
685.0, 1179.0
32.0, 32.0

ATM

--

MO000030934

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m10494

10

false

infinite

0

unit false false false
InterProIPR000005
TRANSPATHMO000030934

--

Go back
1300.0, 450.0
34.0, 34.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
749.0, 239.0
32.0, 32.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p39

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1088.0, 210.0
26.0, 26.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1220.0, 854.0
34.0, 34.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p110

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
564.0, 162.0
34.0, 34.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
411.0, 165.0
36.0, 36.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
720.0, 162.0
34.0, 34.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1131.0, 53.0
28.0, 28.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
291.75, 137.9969080091176
1146.9633005534513, 1665.39071240361

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
518.0, 183.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1379.5, 1479.6920535878144
27.454028262066434, 38.30794641218572

TNF-alpha:TNFR:RIP1{ub}

--

e100

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p68

p69

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
1379.0, 1539.941176470588
28.235294117647058, 47.05882352941177

TNF-alpha:TNFR:RIP1{ub}:IKK-gamma

--

e101

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p69

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
319.0, 545.2941176470588
26.823529411764703, 44.705882352941174

TLR3:TRIF:RIP1{ub}

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p106

p107 p70 p110

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
955.0, 525.0
28.0, 28.0

IRF-3{active}

--

e103

cso30:c:Protein

cso30:i:CC_CellComponent

--

p71

p111

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
959.0, 1480.780487804878
34.02439024390243, 27.21951219512195

RelA-p65{p}

--

e104

cso30:c:Protein

cso30:i:CC_Cytosol

--

p73 p77 p100

p75 p76 p101

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1121.0, 342.2202656470115
40.994163815657075, 25.279734352988527

PKA{active}

--

e105

cso30:c:Protein

cso30:i:CC_Cytosol

--

p74

p73

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1141.0, 442.2202656470115
40.994163815657075, 25.279734352988527

PKA

--

e106

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p74

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
984.5, 1530.606732211298
32.987835360773204, 40.393267788701884

RelA-p65{p}:p300

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
750.5, 1557.155807365439
28.45609065155807, 34.8441926345609

RelA-p65:CBP

--

e108

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p76

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
892.0, 1421.2015395381384
34.95451364590622, 26.798460461861445

RelA-p65{ace}

--

e109

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p78

p79 p81

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
900.5, 737.7641769131951
25.252339878876857, 35.23582308680492

IkappaB{p}-NF-kappaB

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
774.0, 496.2015395381384
34.95451364590622, 26.798460461861445

p50{ace}

--

e111

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p80

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
957.0, 1219.0
23.0, 23.0

IkappaB-alpha

--

e112

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p79

true true true true

csml-variable:Double

m116

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
962.0, 1181.745856353591
30.82872928176796, 34.254143646408835

IkappaB-alpha:p65

--

e113

cso30:c:Complex

cso30:i:CC_Extracellular

--

p79

p81

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
1094.0, 1025.6353591160218
30.928176795580107, 34.3646408839779

IkappaB-alpha:p65

--

e114

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
643.0, 1221.0
28.0, 28.0

IRF-3{active}

--

e115

cso30:c:Protein

cso30:i:CC_CellComponent

--

p111

p72 p88

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
615.0, 1285.0
28.0, 28.0

AP-1{active}

--

e116

cso30:c:Protein

cso30:i:CC_CellComponent

--

p112

p82

true true true true

csml-variable:Double

m120

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
541.0, 1324.8121546961324
32.569060773480665, 36.187845303867405

NF-kappaB:AP1

--

e117

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p82

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
504.5, 1423.7350441593067
24.716380603232796, 30.26495584069322

c/ebp:F-kappaB

--

e118

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p83

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
600.0, 1399.973133427249
34.90843228013685, 21.526866572751057

SP1

--

e119

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p84

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
689.5, 738.7682143512574
23.816113048265738, 33.2317856487429

IkappaB{p}{ub}:NF-kappaB

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
574.0, 1437.911602209945
30.67955801104972, 34.088397790055254

NF-kappaB:SP1

--

e120

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p84

--

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
603.5, 1534.8053657723715
26.292284619230124, 32.19463422762873

NF-kappaB:SRF

--

e121

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p85

--

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
813.0, 1322.8563535911605
30.729281767955808, 34.143646408839786

NF-kappaB:STAT6

--

e122

cso30:c:Complex

cso30:i:CC_Extracellular

--

p86

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
670.5, 1565.0558240293285
28.53774370938177, 34.94417597067156

NF-kappaB:SEF

--

e123

cso30:c:Complex

cso30:i:CC_Extracellular

--

p87

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
716.5, 1507.7929160796941
24.177701750855306, 39.20708392030589

SEF

--

e124

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p87

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
762.5, 1174.3576803083138
29.12699577904203, 40.64231969168655

NF-kappaB:DNA:IRF3

--

e125

cso30:c:Complex

cso30:i:CC_Extracellular

--

p88

--

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
908.0, 1601.840830449827
49.048442906574394, 26.15916955017301

IL-12

--

e126

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p91

p92

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
854.0, 1382.5017301038065
45.93425605536332, 24.498269896193772

IkappaB

--

e127

cso30:c:mRNA

cso30:i:CC_Extracellular

--

p93

p94

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
420.0, 1161.980355472404
22.108512628624883, 51.01964452759589

IkappaB

--

e128

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p94

p95

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
711.0, 1608.761459307764
19.603367633302152, 45.23854069223574

IkappaB

--

e129

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p95

p96

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
861.5, 1111.9463422762874
31.077153807698718, 38.05365772371272

NF-kappaB

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8 p82 p83 p84 p85 p86 p87 p93 p96

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
806.5, 1567.7781244265002
28.10901082767481, 39.22187557349972

NF-kappaB:IkappaB

--

e130

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p96

p97

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
939.0, 1295.8342541436466
27.149171270718234, 30.165745856353585

DNA:NF-kappaB{ub}

--

e132

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p98

p99

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
1098.0, 1416.0
21.0, 21.0

protein remnants

--

e133

cso30:c:Protein

cso30:i:CC_CellComponent

--

p99 p101 p103

--

true true true true

csml-variable:Double

m138

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1030.0, 1287.2682926829268
38.41463414634146, 30.731707317073173

c-Rel{p}

--

e134

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p102

p103

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
318.5, 398.75408331804
28.842906955404665, 40.24591668196

LPS:TLR4:Tollip

--

e135

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p104

--

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
315.5, 466.3415305560653
34.87190310148651, 48.65846944393468

TLR2 ligand:TLR2:TLR6:Tollip

--

e136

cso30:c:Complex

cso30:i:CC_Cytosol

--

p105

--

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
317.5, 633.4086988438246
30.5237658285924, 42.59130115617545

TLR4:TRAM:TRIF

--

e137

cso30:c:Complex

cso30:i:CC_Cytosol

--

p107

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
317.0, 775.4411764705883
32.73529411764706, 54.55882352941177

TLR3:TRIF:RIP1{ub}:TAB2:TAB3:TAK1

--

e138

cso30:c:Complex

cso30:i:CC_Extracellular

--

p110

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
594.5, 949.6658890184968
28.856190634894183, 35.33411098150308

NF-kappaB

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p23 p108

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
859.0, 1280.5
60.0, 13.0

DNA

--

e15

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
847.0, 1230.5
60.0, 17.0

DNA:NF-kappaB

--

e16

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p8

p9 p88 p98

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
896.0, 1315.0
48.892733564013845, 26.07612456747405

gene

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p9

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
810.0, 633.8563535911603
30.7292817679558, 34.14364640883978

A20:IKK-gamma

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
393.5, 692.1961339776703
30.056490584902516, 36.8038660223296

IKK-gamma:RIP

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
291.75, 137.9969080091176
1146.9633005534513, 1665.39071240361

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
440.0, 485.4878048780487
34.390243902439025, 27.51219512195122

IKK-gamma{p}

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

p13 p16

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1384.5, 1194.4577943433458
24.56347292260469, 47.54220565665424

TNF-alpha:TNFR

--

e21

cso30:c:Complex

cso30:i:CC_Extracellular

--

p14

p13 p67

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1378.5, 1329.6176277132208
29.130892348169258, 56.382372286779216

IL1:IL1R

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p16

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1381.5, 1261.493848857645
31.528998242530754, 48.50615114235501

IL-1R

--

e23

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
774.0, 1100.109167249825
37.68369489153254, 28.89083275017495

IKK-gamma{ub}{sumo}:ATM

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

p17

p21

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
474.0, 1067.6137158852343
30.503848845346397, 23.38628411476557

IKK-gamma{sumo}

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
618.0, 1159.6137158852343
30.503848845346397, 23.38628411476557

IKK-gamma{sumo}

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
735.0, 1110.4475138121547
36.49723756906077, 40.552486187845304

IKK-gamma{sumo}:ATM

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p17

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
619.0, 1052.6564030790762
36.96990902729181, 28.34359692092372

IKK-gamma{ub}{sumo}:ATM

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

p21

p22 p23

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
749.5, 947.3664389268455
31.550741543076157, 38.633561073154475

NF-kappaB{active}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23 p108

p7

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
314.689266011069, 160.93617402018668
1101.0847685313133, 1619.5121803814736

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
929.5, 908.7148808531912
23.91618063656057, 29.285119146808857

NF-kappaB:c-Rel

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p24 p25

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
837.5, 870.8693338227199
23.02697742705083, 32.13066617728023

IkappaB-alpha:C-Rel:NF-kappaB

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
930.5, 1059.9614608184988
21.527619746742516, 30.03853918150119

IkappaB-beta:C-Rel:NF-kappaB

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
803.5, 886.7753707715382
26.31678053657723, 32.22462922846192

p65:NF-kappaB

--

e33

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p26 p27

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
815.5, 980.3307028812627
26.996329601761794, 37.66929711873738

IkappaB-alpha:p65:NF-kappaB

--

e34

cso30:c:Complex

cso30:i:CC_Extracellular

--

p26

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
889.5, 1042.7592218755735
23.105890989172323, 32.2407781244265

IkappaB-beta:p65:NF-kappaB

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1265.0, 1406.2209944751382
26.80110497237569, 29.779005524861873

C-Rel: p65

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1217.5, 1467.413837401358
24.786749862360068, 34.586162598641955

IkappaB-epsilon:C-Rel:p65

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
637.5, 1330.4949532024225
23.295283538263906, 32.50504679757754

Bcl-3:(p50)2

--

e38

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p29

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
690.5, 1451.9834832079282
21.511837034318223, 30.016516792071936

Bcl-3:(p52)2

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
357.1269081315469, 201.07988953955714
1016.2094842903579, 1539.2247493427303

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
725.0, 1433.265193370166
24.96132596685083, 27.734806629834253

(p52)2

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
761.0, 1425.2091970215338
32.90400482994566, 20.29080297846649

IkappaB-zeta

--

e41

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p31 p32

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
656.5, 1260.8493301523217
22.324646724169572, 31.15066984767847

(p50)2:IkappaB-zeta

--

e42

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p31

p89 p90 p91 p92

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
772.0, 1468.7679558011048
25.408839779005522, 28.23204419889503

p50:p65

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
824.5, 1367.957423380437
22.963846577353642, 32.04257661956323

p50:p65:IkappaB-zeta

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1016.0, 157.3235294117647
26.205882352941174, 43.67647058823529

LPS:TLR4:TIRAP:MYD88

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p52

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
854.0, 40.11862917398946
45.20210896309315, 29.381370826010546

TLR3 ligand

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
816.5, 154.8002631001973
25.419864064898047, 49.19973689980268

TLR3 ligand:TLR3

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
771.5, 160.44081482840886
26.917416039640308, 37.559185171591125

TLR3 ligand: TLR3: TRIF

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p65

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
919.0, 155.6764705882353
27.79411764705882, 46.32352941176472

LPS:TLR4:TRAM:TRIF

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p66

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
635.0, 697.0
28.0, 28.0

IKK

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3 p22

p4

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
484.0, 1081.0
665.1983300922095, 603.2618002884662

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
555.8463745723429, 1095.296427662125
388.9614071675118, 584.680841347343

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
492.6711141725242, 1089.0517488744865
647.8561017471617, 587.1583025394925

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
493.909844768599, 1090.2904794705614
645.3786405550114, 584.680841347343

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
484.0, 1081.0
665.1983300922095, 603.2618002884662

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
484.0, 1081.0
665.1983300922095, 603.2618002884662

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
497.909844768599, 1090.2904794705614
645.3786405550114, 584.680841347343

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
969.5823936613517, 1328.7461192149758
41.557936729226626, 37.620869039089435

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
862.5741012067626, 1502.1684026654586
117.67940662711335, 106.53083126243969

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
484.0, 1081.0
665.1983300922095, 603.2618002884662

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
895.5, 576.1435125711141
27.130482657368326, 37.856487428886034

IkappaB-NF-kappaB

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p97

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
640.7835035893537, 1349.0845592549022
21.065853707744733, 10.142818451877108

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
640.0800551054344, 1318.8362744463766
72.10346960171692, 129.78624528309055

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
670.3283399139602, 1403.25009251668
11.25517574270702, 11.255175742707035

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
968.5, 162.11855386309412
24.281703064782526, 33.88144613690586

LPS:TLR4:TRAM

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1242.5, 156.50087873462212
28.924428822495607, 44.49912126537786

TLR1:TLR2

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1308.0, 49.03778558875223
42.249560632688926, 27.462214411247807

TLR2 ligand

--

e65

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p40 p43

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1291.5, 152.31440473580358
27.737557553168166, 53.68559526419645

TLR2 ligand:TLR1:TLR2

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1331.5, 160.1655349605432
27.11469994494403, 37.83446503945679

TLR1:TLR2:TIRAP

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1372.0, 176.1470588235294
26.91176470588236, 44.852941176470594

TLR1:TLR2:TIRAP:MYD88

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1377.5, 227.6537785588752
30.7750439367311, 47.34622144112477

TLR2:TLR6

--

e69

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p43

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1128.5, 154.40561280420957
25.623766717825042, 49.5943871957904

LPS:TLR4

--

e7

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34 p38 p74 p104

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
1380.5, 286.8528831396623
25.39267704450778, 49.14711686033764

TLR2ligand:TLR2:TLR6

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44 p105

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1377.5, 345.9812809689851
30.11341530556065, 42.018719031014875

TLR2 ligand:TLR2:TLR6:TIRAP

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p45

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1376.0, 400.7352941176471
26.558823529411768, 44.26470588235294

TLR2 ligand: TLR2:TLR6: TIRAP:MYD88

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
713.0, 33.865553602811985
39.437609841827765, 25.63444639718805

TLR7 ligand

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
672.5, 153.87941240955934
25.89563692172769, 50.12058759044069

TLR7 ligand: TLR7

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p47

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
614.5, 159.06239677004953
28.621948981464488, 39.93760322995045

TLR7 ligand:TLR7:MYD88

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
523.5, 157.60315720236792
26.03836877877658, 50.3968427976321

e76

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p49

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
474.0, 40.296133567662594
46.467486818980674, 30.203866432337435

TLR8 ligand

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p48

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
469.5, 157.60690034868782
30.381721416773722, 42.39309965131218

TLR8 ligand:TLR8:MYD88

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
367.5, 153.51129138346852
26.60249945187459, 51.48870861653146

TLR9 ligand: TLR9

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1074.5, 158.3797026977427
29.11121306661773, 40.6202973022573

LPS:TLR4:TIRAP

--

e8

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
260.0, 65.06063268892797
42.21441124780316, 27.43936731107206

TLR9 ligand

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
321.5, 209.6048816296568
31.099834832079285, 43.39511837034319

TLR9 ligand:TLR9:MYD88

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1381.0, 482.2647058823529
24.441176470588232, 40.73529411764706

LPS:TLR4:TIRAP:MYD88:IRAK-4

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p54

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1304.0, 525.8199999999999
34.24, 25.68

IRAK1

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p54

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1384.0, 596.2941176470588
26.823529411764707, 44.705882352941174

LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1{p}

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p55

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1378.0, 556.6764705882354
21.794117647058826, 36.3235294117647

LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p53

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1380.0, 661.1764705882354
26.294117647058822, 43.82352941176471

LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1{p}:TRAF6

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p56

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1375.0, 720.5588235294118
27.26470588235294, 45.44117647058824

LPS:TLR4:TIRAP:MYD88:IRAK-4:IRAK1{p}{ub}:TRAF6

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1384.0, 784.8823529411766
23.47058823529412, 39.117647058823536

LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57 p109

p58 p59 p60

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1376.0, 841.7941176470589
25.32352941176471, 42.20588235294118

LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub}

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p59 p109

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
327.0, 186.0
1068.8658357094266, 1538.6640369511226

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1292.0, 799.4917127071823
34.65745856353592, 38.50828729281768

UBC13:Uev1A

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p58

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1380.0, 937.7647058823529
25.941176470588232, 43.23529411764706

LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub}:TAB1:TAB2:TAB3

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p60

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1376.0, 1016.1470588235293
26.911764705882355, 44.852941176470594

LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub}:TAB1:TAB2:TAB3:TAK1

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

p61

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1380.0, 1069.205882352941
25.676470588235297, 42.794117647058826

LPS:TLR4:TIRAP:MYD88:IRAK-4:TRAF6{ub}:TAB1:TAB2:TAB3:TAK1{active}

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

p62 p63 p64

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1022.0, 740.0
30.0, 30.0

JNK{active}

--

e94

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

--

true true true true

csml-variable:Double

m95

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1105.0, 931.0
32.0, 32.0

p38

--

e95

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

--

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1191.0, 1197.0
28.0, 28.0

AP-1{active}

--

e96

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64

p112

true true true true

csml-variable:Double

m98

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
315.0, 270.7647058823529
25.941176470588232, 43.23529411764706

TLR3 ligand:TLR3:TRIF RIP1

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65 p70

p71 p106 p108 p110

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
320.0, 324.2941176470588
26.823529411764707, 44.705882352941174

LPS:TLR4:TRAM:TRIF:RIP1

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1377.5, 1409.7920719398057
30.965681776472753, 43.20792806019455

TNF-alpha:TNFR:RIP1

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p68

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
690.0, 380.5
21.5, 21.5

p1

p1

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

MO000000199

MO000000200

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m171*0.1

nodelay

--

true

0

false

PMID: 17349209 p50 is generated from limited proteasomal processing of the p105 protein as is p52 from the p100 protein.

Go back
455.0, 681.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000210 MO000000211 MO000016599

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m181*m182*m1593*0.1

nodelay

--

true

0

false

PMID: 17349209, 16987664 In addition to interacting with IKK¦Á and IKK¦Â, IKK¦Ã/NEMO also interacts with a number of proteins associated with NF-¦ÊB activation including RIP and A20.

Go back
1019.0, 1409.0
19.0, 19.0

p100

p100

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000000193 MO000000210

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c279 : 1
stoichiometry:c281 : 1
stoichiometry:c280 : 1

m166*m181*0.1

nodelay

--

true

0

false

PMID: 17349209 IKK¦Á phosphorylation of p65 and c-Rel targets them for proteasomal degradation in the nucleus and is a key event in the termination of the NF-¦ÊB response to TLR stimulation.

Go back
1066.0, 1484.0
21.0, 21.0

p101

p101

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

e104

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c283 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17349209 IKK¦Á phosphorylation of p65 and c-Rel targets them for proteasomal degradation in the nucleus and is a key event in the termination of the NF-¦ÊB response to TLR stimulation.

Go back
1013.0, 1239.0
23.0, 23.0

p102

p102

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000000192 MO000000210

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c286 : 1
stoichiometry:c285 : 1

m165*m181*0.1

nodelay

--

true

0

false

PMID: 17349209 IKK¦Á phosphorylation of p65 and c-Rel targets them for proteasomal degradation in the nucleus and is a key event in the termination of the NF-¦ÊB response to TLR stimulation.

Go back
1063.0, 1241.0
19.0, 19.0

p103

p103

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Extracellular

--

e134

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c288 : 1

m139*0.1

nodelay

--

true

0

false

PMID: 17349209 IKK¦Á phosphorylation of p65 and c-Rel targets them for proteasomal degradation in the nucleus and is a key event in the termination of the NF-¦ÊB response to TLR stimulation.

Go back
1033.0, 307.0
23.0, 23.0

p104

p104

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e7 MO000019406

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c289 : 1
stoichiometry:c291 : 1
stoichiometry:c290 : 1

m7*m3973*0.1

nodelay

--

true

0

false

PMID: 17349209, 11751856 TOLLIP interacts with TLR2 and TLR4 as well as IRAK1 and interferes with the activation of NF-¦ÊB through MyD88-dependent pathways.

Go back
939.0, 293.0
19.0, 19.0

p105

p105

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019406 e70

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c292 : 1
stoichiometry:c293 : 1
stoichiometry:c294 : 1

m3973*m70*0.1

nodelay

--

true

0

false

PMID: 17349209, 11751856 TOLLIP interacts with TLR2 and TLR4 as well as IRAK1 and interferes with the activation of NF-¦ÊB through MyD88-dependent pathways.

Go back
535.0, 253.0
19.0, 19.0

p106

p106

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016591 e97

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m1585*m100*0.1

nodelay

--

true

0

false

PMID: 17349209 In addition, a C-terminal ubiquitin ligase domain of A20 mediates the K48-polyubiquitination of RIP1 leading to its proteasomal degradation.

Go back
430.0, 352.0
21.0, 21.0

p107

p107

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e102

MO000019479 e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c299 : 1
stoichiometry:c295 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 17349209 In addition, a C-terminal ubiquitin ligase domain of A20 mediates the K48-polyubiquitination of RIP1 leading to its proteasomal degradation.

Go back
694.0, 903.5
22.5, 22.5

p108

p108

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14 e97

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c300 : 1
stoichiometry:c302 : 1
stoichiometry:c301 : 1

m14*m100*0.1

nodelay

--

true

0

false

PMID: 17349209, 12471095 TLR3 instead exclusively uses the adaptor protein TRIF which binds directly to the receptor upon activation and is critical in the activation of NF-¦ÊB and the induction of interferon-¦Â expression through activation of IRF3.

Go back
1643.0, 1575.0
25.0, 25.0

p109

p109

cso30:i:ME_Deubiquitination

cso30:i:CC_Extracellular

--

e89 MO000016591

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c304 : 1
stoichiometry:c306 : 1
stoichiometry:c305 : 1

m89*m1585*0.1

nodelay

--

true

0

false

PMID: 17349209 The N-terminal domain of A20 contains a de-ubiquitinating activity which removes K63-polyubiquitin chains from both RIP1 and TRAF6, thereby inhibiting the recruitment and activation of the TAK1/TAB2/TAB3 complex.

Go back
731.0, 641.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016599 MO000016591

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m1593*m1585*0.1

nodelay

--

true

0

false

PMID: 17349209, 16987664 In addition to interacting with IKK¦Á and IKK¦Â, IKK¦Ã/NEMO also interacts with a number of proteins associated with NF-¦ÊB activation including RIP and A20.

Go back
188.0, 684.0
23.0, 23.0

p110

p110

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e102 MO000041541 MO000022125 MO000016574 e97

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c309 : 1
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1
stoichiometry:c314 : 1
stoichiometry:c313 : 1

m105*m19389*m6433*m1573*0.1

nodelay

--

true

0

false

PMID: 17349209 The N-terminal domain of A20 contains a de-ubiquitinating activity which removes K63-polyubiquitin chains from both RIP1 and TRAF6, thereby inhibiting the recruitment and activation of the TAK1/TAB2/TAB3 complex.

Go back
618.0, 1114.0
19.0, 19.0

p19

p111

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e103

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c315 : 1
stoichiometry:c316 : 1

m107*0.1

nodelay

--

true

0

false

--

Go back
1117.0, 1233.0
30.0, 30.0

p112

p112

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e96

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c318 : 1

m98*0.1

nodelay

--

true

0

false

--

Go back
406.0, 644.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016599 MO000000208

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m1593*m179*0.1

nodelay

--

true

0

false

PMID: 17349209, 16987664 In addition to interacting with IKK¦Á and IKK¦Â, IKK¦Ã/NEMO also interacts with a number of proteins associated with NF-¦ÊB activation including RIP and A20.

Go back
610.0, 552.0
21.0, 21.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016599 e21 MO000000211

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c37 : 1
stoichiometry:c61 : 1
stoichiometry:c33 : 1

m1593*m21*m182*0.1

nodelay

--

true

0

false

PMID: 17349209 The phosphorylation of IKK¦Ã/NEMO has been reported to occur following TNF-¦Á and IL-1 stimulation and appears to negatively regulate IKK activity. PMID: 17349209, 12657630, 11971901 The phosphorylation occurs primarily on serine 376 and is IKK¦Â dependent, indicating that this may be an autoregulatory mechanism.

Go back
1470.0, 1195.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000205 MO000000289

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m176*m230*0.1

nodelay

--

true

0

false

Go back
1450.0, 1339.0
21.0, 21.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e23 MO000000214

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m23*m185*0.1

nodelay

--

true

0

false

Go back
471.0, 549.0
19.0, 19.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016599 e22 MO000000211

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c62 : 1
stoichiometry:c42 : 1

m1593*m22*m182*0.1

nodelay

--

true

0

false

PMID: 17349209 The phosphorylation of IKK¦Ã/NEMO has been reported to occur following TNF-¦Á and IL-1 stimulation and appears to negatively regulate IKK activity.

Go back
802.0, 1143.5
22.5, 22.5

p17

p17

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e27

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17349209 The polyubiquitination of IKK¦Ã/NEMO occurs through K63-linked chains and does not target the protein for degradation but instead appears to serve as a posttranslational modification signal rather like phosphorylation. PMID: 17349209, 16497931 In the case of NEMO, sumolyation induces its nuclear localisation and interaction with the DNA damage sensor ATM which then triggers IKK¦Ã/NEMO mono-ubiquitination and nuclear export.

Go back
486.0, 964.0
21.0, 21.0

p18

p18

cso30:i:ME_Sumoylation

cso30:i:CC_Cytosol

--

MO000016599

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m1593*0.1

nodelay

--

true

0

false

PMID: 17349209, 14651848 The sumolyation of IKK¦Ã/NEMO has been identified as an important mechanism for the activation of NF-¦ÊB in response to genotoxic stress

Go back
515.0, 1149.0
19.0, 19.0

p19

p19

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 17349209, 16497931 In the case of NEMO, sumolyation induces its nuclear localisation and interaction with the DNA damage sensor ATM which then triggers IKK¦Ã/NEMO mono-ubiquitination and nuclear export.

Go back
552.0, 360.0
21.0, 21.0

p2

p2

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

MO000000202

MO000000196

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1

m173*0.1

nodelay

--

true

0

false

PMID: 17349209 p50 is generated from limited proteasomal processing of the p105 protein as is p52 from the p100 protein.

Go back
690.0, 1136.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e26 MO000030934

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m26*m10494*0.1

nodelay

--

true

0

false

PMID: 17349209, 16497931 In the case of NEMO, sumolyation induces its nuclear localisation and interaction with the DNA damage sensor ATM which then triggers IKK¦Ã/NEMO mono-ubiquitination and nuclear export.

Go back
727.0, 1057.0
19.0, 19.0

p21

p21

cso30:i:ME_NuclearExport

cso30:i:CC_Cytosol

--

e24

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 17349209, 16497931 In the case of NEMO, sumolyation induces its nuclear localisation and interaction with the DNA damage sensor ATM which then triggers IKK¦Ã/NEMO mono-ubiquitination and nuclear export.

Go back
714.0, 808.0
21.0, 21.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e28

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m207*m28*0.1

nodelay

--

true

0

false

PMID: 17349209 The cytoplasmic IKK¦Ã/NEMO and ATM complex then activates the IKK complex and NF-¦ÊB through an unknown mechanism.

Go back
688.0, 957.5
18.5, 18.5

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m14*m28*0.1

nodelay

--

true

0

false

PMID: 17349209 The cytoplasmic IKK¦Ã/NEMO and ATM complex then activates the IKK complex and NF-¦ÊB through an unknown mechanism.

Go back
890.0, 876.5
21.5, 21.5

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000233 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m199*m30*0.1

nodelay

--

true

0

false

PMID: 17349209, 2691328, 7867065, 1340770 I¦ÊB¦Á and I¦ÊB¦Â preferentially bind c-Rel and p65 containing dimers.

Go back
931.0, 1013.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000234 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m200*m30*0.1

nodelay

--

true

0

false

PMID: 17349209, 2691328, 7867065, 1340770 I¦ÊB¦Á and I¦ÊB¦Â preferentially bind c-Rel and p65 containing dimers.

Go back
819.0, 937.0
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000233 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m199*m33*0.1

nodelay

--

true

0

false

PMID: 17349209, 2691328, 7867065, 1340770 I¦ÊB¦Á and I¦ÊB¦Â preferentially bind c-Rel and p65 containing dimers.

Go back
889.0, 971.0
23.0, 23.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000234 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m200*m33*0.1

nodelay

--

true

0

false

PMID: 17349209, 2691328, 7867065, 1340770 I¦ÊB¦Á and I¦ÊB¦Â preferentially bind c-Rel and p65 containing dimers.

Go back
1221.0, 1368.0
17.0, 17.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000237 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m203*m36*0.1

nodelay

--

true

0

false

PMID: 17349209, 9135156 I¦ÊB¦Å only binds c-Rel and p65 complexes.

Go back
635.0, 1377.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000016636 MO000000238

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m1621*m204*0.1

nodelay

--

true

0

false

PMID: 17349209, 8336935, 8497270 Bcl-3 binds only p50 and p52 homodimers.

Go back
510.0, 720.0
21.0, 21.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m207*0.1

nodelay

--

true

0

false

PMID: 17349209 Activation of the IKK complex induces phosphorylation of the I¦ÊB proteins, leading to their K48-polyubiquitination and proteasomal degradation.

Go back
664.0, 1401.5
18.5, 18.5

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000000238 e40

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m204*m40*0.1

nodelay

--

true

0

false

PMID: 17349209, 8336935, 8497270 Bcl-3 binds only p50 and p52 homodimers.

Go back
695.0, 1293.0
19.0, 19.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000016636 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m1621*m41*0.1

nodelay

--

true

0

false

PMID: 17349209, 17027520 I¦ÊB¦Æ binds both p50 homodimers and p65/p50 dimers. PMID: 17349209, 15241416 I¦ÊB¦Æ is itself a TLR inducible gene which associates with p50 and is critical for the induction of the pro-inflammatory cytokines IL-6 and IL-12 following TLR stimulation in macrophages.

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818.0, 1428.0
21.0, 21.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m41*m43*0.1

nodelay

--

true

0

false

PMID: 17349209, 17027520 I¦ÊB¦Æ binds both p50 homodimers and p65/p50 dimers.

Go back
1197.0, 95.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042409 MO000019394

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m157177*m3961*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
1154.0, 224.0
21.0, 21.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e7 MO000022528

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m7*m6810*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
1042.0, 92.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e8 MO000016573

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c104 : 1

m8*m1572*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
819.0, 85.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m3965*m46*0.1

nodelay

--

true

0

false

PMID: 17349209 TRIF is associated only with TLR4 and TLR3, binding directly to TLR3 and using the bridging adaptor TRAM to bind to TLR4.

Go back
818.0, 224.0
21.0, 21.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m18998*m47*0.1

nodelay

--

true

0

false

PMID: 17349209 TRIF is associated only with TLR4 and TLR3, binding directly to TLR3 and using the bridging adaptor TRAM to bind to TLR4.

Go back
1133.0, 255.0
23.0, 23.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e7 MO000041132

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m7*m19005*0.1

nodelay

--

true

0

false

PMID: 17349209 TRIF is associated only with TLR4 and TLR3, binding directly to TLR3 and using the bridging adaptor TRAM to bind to TLR4.

Go back
970.0, 244.0
21.0, 21.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000041125

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m63*m18998*0.1

nodelay

--

true

0

false

PMID: 17349209 TRIF is associated only with TLR4 and TLR3, binding directly to TLR3 and using the bridging adaptor TRAM to bind to TLR4.

Go back
875.0, 669.0
19.0, 19.0

p4

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e6 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 17349209 Activation of the IKK complex induces phosphorylation of the I¦ÊB proteins, leading to their K48-polyubiquitination and proteasomal degradation.

Go back
1265.0, 87.0
24.0, 24.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m64*m65*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
1360.0, 98.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m6810*m66*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
1429.0, 103.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 MO000016573

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m67*m1572*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
1463.0, 241.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e69 e65

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m69*m65*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
1457.0, 299.0
23.0, 23.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000022528

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m70*m6810*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
1472.0, 358.0
17.0, 17.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 MO000016573

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m71*m1572*0.1

nodelay

--

true

0

false

PMID: 17349209 TIRAP acts as a bridging adaptor between TLR4, TLR1/2, TLR2/6 and MyD88.

Go back
676.0, 70.0
25.0, 25.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1

m19940*m73*0.1

nodelay

--

true

0

false

PMID: 17349209 MyD88 interacts with TLRs 7, 8 and 9 via its C-terminal TIR domain and associates with all the other TLRs through the bridging adaptor TIRAP.

Go back
624.0, 82.0
17.0, 17.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e74 MO000016573

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m74*m1572*0.1

nodelay

--

true

0

false

PMID: 17349209 MyD88 interacts with TLRs 7, 8 and 9 via its C-terminal TIR domain and associates with all the other TLRs through the bridging adaptor TIRAP.

Go back
545.0, 67.0
23.0, 23.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e77

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c137 : 1
stoichiometry:c136 : 1

m19823*m77*0.1

nodelay

--

true

0

false

PMID: 17349209 MyD88 interacts with TLRs 7, 8 and 9 via its C-terminal TIR domain and associates with all the other TLRs through the bridging adaptor TIRAP.

Go back
426.0, 80.0
21.0, 21.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e76 MO000016573

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m76*m1572*0.1

nodelay

--

true

0

false

PMID: 17349209 MyD88 interacts with TLRs 7, 8 and 9 via its C-terminal TIR domain and associates with all the other TLRs through the bridging adaptor TIRAP.

Go back
791.0, 745.0
19.0, 19.0

p5

p5

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17349209 Activation of the IKK complex induces phosphorylation of the I¦ÊB proteins, leading to their K48-polyubiquitination and proteasomal degradation.

Go back
370.0, 68.0
21.0, 21.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e80

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c142 : 1

m19828*m80*0.1

nodelay

--

true

0

false

Go back
230.0, 176.0
21.0, 21.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e79 MO000016573

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c145 : 1

m79*m1572*0.1

nodelay

--

true

0

false

PMID: 17349209 MyD88 interacts with TLRs 7, 8 and 9 via its C-terminal TIR domain and associates with all the other TLRs through the bridging adaptor TIRAP.

Go back
1495.0, 457.0
19.0, 19.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 e45

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m17258*m45*0.1

nodelay

--

true

0

false

PMID: 17349209 MyD88 also binds to the kinase IRAK4 through death domains contained in both proteins.

Go back
1271.0, 577.0
19.0, 19.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e85

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c151 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17349209 Receptor associated IRAK4 subsequently phosphorylates IRAK1, which in turn complexes with the E3 ubiquitin ligase TRAF6.

Go back
1487.0, 529.0
19.0, 19.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e82 e83

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m82*m83*0.1

nodelay

--

true

0

false

PMID: 17349209 This allows the formation of a complex which includes IRAK1, IRAK4 and TRAF6.

Go back
1496.0, 610.0
17.0, 17.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e84 MO000000212

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m84*m183*0.1

nodelay

--

true

0

false

PMID: 17349209 Receptor associated IRAK4 subsequently phosphorylates IRAK1, which in turn complexes with the E3 ubiquitin ligase TRAF6.

Go back
1470.0, 688.0
21.0, 21.0

p56

p56

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 17349209, 9261174 Phosphorylated IRAK1 undergoes ubiquitination and proteasomal degradation which most likely serves as a negative feedback loop for TRAF6 activation

Go back
1457.0, 763.0
23.0, 23.0

p57

p57

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e87

e88 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 17349209, 9261174 Phosphorylated IRAK1 undergoes ubiquitination and proteasomal degradation which most likely serves as a negative feedback loop for TRAF6 activation

Go back
1468.0, 850.0
25.0, 25.0

p58

p58

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e88 e90

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m88*m90*0.1

nodelay

--

true

0

false

PMID: 17349209, 11460167 Activated TRAF6 undergoes K63-mediated polyubiquitination which differs from the K48 form of polyubiquitination in that it does not lead to proteasomal degradation. PMID: 17349209 The polyubiquitination of TRAF6 appears to be mediated by an E2 complex containing UBC13 and UEV1A.

Go back
1599.0, 907.0
25.0, 25.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e89 MO000016588 MO000022125 MO000041541 e88

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c307 : 1
stoichiometry:c170 : 1

m89*m1583*m6433*m19389*0.1

nodelay

--

true

0

false

PMID: 17349209 The exact role of TRAF6 polyubiquitination is unclear but it appears to be necessary for the recruitment of TAB1, TAB2 and TAB3. PMID: 17349209 The N-terminal domain of A20 contains a de-ubiquitinating activity which removes K63-polyubiquitin chains from both RIP1 and TRAF6, thereby inhibiting the recruitment and activation of the TAK1/TAB2/TAB3 complex.

Go back
609.0, 743.0
23.0, 23.0

p6

p6

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e12

MO000019479 e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 17349209 Activation of the IKK complex induces phosphorylation of the I¦ÊB proteins, leading to their K48-polyubiquitination and proteasomal degradation.

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1543.0, 985.0
19.0, 19.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e91 MO000016574 e88

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1
stoichiometry:c308 : 1
stoichiometry:c173 : 1

m91*m1573*0.1

nodelay

--

true

0

false

PMID: 17349209, 11460167, 14633987, 14670075 Both TAB2 and TAB3 proteins share the ability to interact with and activate the kinase TAK1. PMID: 17349209 The N-terminal domain of A20 contains a de-ubiquitinating activity which removes K63-polyubiquitin chains from both RIP1 and TRAF6, thereby inhibiting the recruitment and activation of the TAK1/TAB2/TAB3 complex.

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1463.0, 1065.0
19.0, 19.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 17349209, 11460167, 14633987, 14670075 Both TAB2 and TAB3 proteins share the ability to interact with and activate the kinase TAK1. PMID: 17349209 The mechanism of TAK1 activation by recruitment to the TRAF6/TAB2/TAB3 complex is unclear but it may involve a trans-autophosphorylation event induced by dimerisation or oligomerisation.

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1049.0, 687.0
23.0, 23.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c178 : 1
stoichiometry:c177 : 1

m94*m93*0.1

nodelay

--

true

0

false

PMID: 17349209, 16186825 In addition to NF-¦ÊB activation, TAK1 is also required for the activation of JNK and p38 and subsequent AP-1 activity following TLR stimulation.

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1138.0, 884.0
21.0, 21.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000022 e93

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c181 : 1
stoichiometry:c180 : 1

m96*m93*0.1

nodelay

--

true

0

false

PMID: 17349209, 16186825 In addition to NF-¦ÊB activation, TAK1 is also required for the activation of JNK and p38 and subsequent AP-1 activity following TLR stimulation.

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1199.0, 1153.0
19.0, 19.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e93

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m219*m93*0.1

nodelay

--

true

0

false

PMID: 17349209, 16186825 In addition to NF-¦ÊB activation, TAK1 is also required for the activation of JNK and p38 and subsequent AP-1 activity following TLR stimulation.

Go back
706.0, 272.0
21.0, 21.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 MO000000065

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m48*m99*0.1

nodelay

--

true

0

false

PMID: 17349209 In this case, RIP1 binds to a RIP homotypic interaction motif (RHIM) in TRIF to trigger downstream NF-¦ÊB activating events.

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874.0, 304.0
21.0, 21.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000000065

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m49*m99*0.1

nodelay

--

true

0

false

PMID: 17349209 In this case, RIP1 binds to a RIP homotypic interaction motif (RHIM) in TRIF to trigger downstream NF-¦ÊB activating events.

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1177.0, 1251.0
23.0, 23.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000000065

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m21*m99*0.1

nodelay

--

true

0

false

PMID: 17349209, 10755617, 16543241, 16547522 RIP1 has been reported to be K63-polyubiquitinated upon recruitment to the TNFR which facilitates its interaction with IKK¦Ã via a C-terminal ubiquitin binding domain in IKK¦Ã

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1455.0, 1449.0
19.0, 19.0

p68

p68

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 17349209, 10755617, 16543241, 16547522 RIP1 has been reported to be K63-polyubiquitinated upon recruitment to the TNFR which facilitates its interaction with IKK¦Ã via a C-terminal ubiquitin binding domain in IKK¦Ã

Go back
1294.0, 1512.0
21.0, 21.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e100 MO000016599

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m103*m1593*0.1

nodelay

--

true

0

false

PMID: 17349209, 10755617, 16543241, 16547522 RIP1 has been reported to be K63-polyubiquitinated upon recruitment to the TNFR which facilitates its interaction with IKK¦Ã via a C-terminal ubiquitin binding domain in IKK¦Ã

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801.0, 1039.0
23.0, 23.0

p7

p7

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e29

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c16 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17349209 The degradation of I¦ÊB protein allows for translocation of the liberated NF-¦ÊB dimers to the nucleus where they bind their cognate sites in DNA and activate gene transcription.

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179.0, 601.0
19.0, 19.0

p70

p70

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

e102 MO000016591

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c296 : 1
stoichiometry:c303 : 1
stoichiometry:c298 : 1

m105*m1585*0.1

nodelay

--

true

0

false

PMID: 17349209 The N-terminal domain of A20 contains a de-ubiquitinating activity which removes K63-polyubiquitin chains from both RIP1 and TRAF6, thereby inhibiting the recruitment and activation of the TAK1/TAB2/TAB3 complex.

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959.0, 449.0
19.0, 19.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e97

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c204 : 1
stoichiometry:c203 : 1

m977*m100*0.1

nodelay

--

true

0

false

PMID: 17349209, 12471095 TLR3 instead exclusively uses the adaptor protein TRIF which binds directly to the receptor upon activation and is critical in the activation of NF-¦ÊB and the induction of interferon-¦Â expression through activation of IRF3.

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1080.0, 1282.0
25.0, 25.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e115

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c317 : 1
stoichiometry:c206 : 1

m119*0.1

nodelay

--

true

0

false

PMID: 17349209, 12471095 TLR3 instead exclusively uses the adaptor protein TRIF which binds directly to the receptor upon activation and is critical in the activation of NF-¦ÊB and the induction of interferon-¦Â expression through activation of IRF3.

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950.0, 1420.0
21.0, 21.0

p73

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000193 e105

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c208 : 1

m166*m109*0.1

nodelay

--

true

0

false

PMID: 17349209, 9150141, 11931769 Phosphorylation of S276 in the Rel homology domain of p65 by protein kinase A is an important regulatory event which occurs during TLR4 signaling.

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1162.0, 395.5
22.5, 22.5

p74

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e106 e7

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c211 : 1

m110*m7*0.1

nodelay

--

true

0

false

PMID: 17349209, 9150141, 11931769 Phosphorylation of S276 in the Rel homology domain of p65 by protein kinase A is an important regulatory event which occurs during TLR4 signaling.

Go back
1022.0, 1472.0
21.0, 21.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e104 MO000019984

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c215 : 1
stoichiometry:c214 : 1

m108*m4512*0.1

nodelay

--

true

0

false

PMID: 17349209, 8246997, 8437855 In addition, S276 phosphorylation enhances the binding of the transcriptional enhancers CBP and p300 to p65, leading to effective removal of repressive histone deacetylase complexes from target genes

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856.0, 1482.0
25.0, 25.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000017462 e104

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m2282*m108*0.1

nodelay

--

true

0

false

PMID: 17349209, 8246997, 8437855 In addition, S276 phosphorylation enhances the binding of the transcriptional enhancers CBP and p300 to p65, leading to effective removal of repressive histone deacetylase complexes from target genes

Go back
990.0, 1424.0
21.0, 21.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000193 MO000000211

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c221 : 1
stoichiometry:c220 : 1

m166*m182*0.1

nodelay

--

true

0

false

PMID: 17349209, 12759443 IKK¦Â has been identified as the key kinase in the TLR4-induced phosphorylation of p65 on S536.

Go back
925.0, 1357.0
21.0, 21.0

p78

p78

cso30:i:ME_Acetylation

cso30:i:CC_Nucleoplasm

--

MO000000193

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m166*0.1

nodelay

--

true

0

false

PMID: 17349209, 12456660 Three primary acetylation sites have been identified in p65, i.e., K218, K221 and K310, each of which has a distinct modulatory effect on the transcriptional activities of NF-¦ÊB

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997.0, 1299.0
15.0, 15.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000000193 e112 e109

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c227 : 1
stoichiometry:c229 : 1
stoichiometry:c228 : 1

m166*m116*0.1

nodelay

--

true

0

false

PMID: 17349209, 11533489 Acetylation of p65 on K218 and K221 significantly reduces its ability to interact with I¦ÊB¦Á, thereby extending the duration of the NF-¦ÊB response in the nucleus by preventing the nuclear export of NF-¦ÊB/I¦ÊB¦Á complexes

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895.0, 1185.0
19.0, 19.0

p8

p8

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e13 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m13*m15*0.1

nodelay

--

true

0

false

PMID: 17349209 The degradation of I¦ÊB protein allows for translocation of the liberated NF-¦ÊB dimers to the nucleus where they bind their cognate sites in DNA and activate gene transcription.

Go back
780.0, 453.0
23.0, 23.0

p80

p80

cso30:i:ME_Acetylation

cso30:i:CC_Cytoplasm

--

MO000000200

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c226 : 1

m172*0.1

nodelay

--

true

0

false

PMID: 17349209, 11739381, 12471036 The p50 subunit of NF-¦ÊB is also acetylated, at K431 and K440, which appears to enhance the transcriptional activity and DNA binding activity of modified heterodimers.

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921.0, 1127.5
23.5, 23.5

p81

p81

cso30:i:ME_NuclearExport

cso30:i:CC_Nucleoplasm

--

e113 e109

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c232 : 1
stoichiometry:c231 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 17349209, 11533489 Acetylation of p65 on K218 and K221 significantly reduces its ability to interact with I¦ÊB¦Á, thereby extending the duration of the NF-¦ÊB response in the nucleus by preventing the nuclear export of NF-¦ÊB/I¦ÊB¦Á complexes

Go back
551.0, 1245.0
19.0, 19.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e116 e13

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c245 : 1
stoichiometry:c235 : 1

m120*m13*0.1

nodelay

--

true

0

false

PMID: 17349209, 8321203, 8798413, 8404856, 8253080, 7935378, 8670842, 9584180, 10899169 NF-¦ÊB has been reported to interact with a number of transcription factors, including C/EBP , AP-1, Sp-1, SRF , STAT6 and SEF

Go back
548.0, 1370.0
17.0, 17.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000019416 e13

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c237 : 1

m3981*m13*0.1

nodelay

--

true

0

false

PMID: 17349209, 8321203, 8798413, 8404856, 8253080, 7935378, 8670842, 9584180, 10899169 NF-¦ÊB has been reported to interact with a number of transcription factors, including C/EBP , AP-1, Sp-1, SRF , STAT6 and SEF

Go back
567.0, 1381.0
20.0, 20.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e119 e13

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c234 : 1
stoichiometry:c241 : 1

m123*m13*0.1

nodelay

--

true

0

false

PMID: 17349209, 8321203, 8798413, 8404856, 8253080, 7935378, 8670842, 9584180, 10899169 NF-¦ÊB has been reported to interact with a number of transcription factors, including C/EBP , AP-1, Sp-1, SRF , STAT6 and SEF

Go back
544.0, 1470.0
17.0, 17.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000000059 e13

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c236 : 1
stoichiometry:c244 : 1

m125*m13*0.1

nodelay

--

true

0

false

PMID: 17349209, 8321203, 8798413, 8404856, 8253080, 7935378, 8670842, 9584180, 10899169 NF-¦ÊB has been reported to interact with a number of transcription factors, including C/EBP , AP-1, Sp-1, SRF , STAT6 and SEF

Go back
747.0, 1329.0
19.0, 19.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000013130 e13

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c248 : 1
stoichiometry:c247 : 1

m1368*m13*0.1

nodelay

--

true

0

false

PMID: 17349209, 8321203, 8798413, 8404856, 8253080, 7935378, 8670842, 9584180, 10899169 NF-¦ÊB has been reported to interact with a number of transcription factors, including C/EBP , AP-1, Sp-1, SRF , STAT6 and SEF

Go back
669.0, 1507.0
23.0, 23.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e124 e13

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c251 : 1
stoichiometry:c249 : 1

m129*m13*0.1

nodelay

--

true

0

false

PMID: 17349209, 8321203, 8798413, 8404856, 8253080, 7935378, 8670842, 9584180, 10899169 NF-¦ÊB has been reported to interact with a number of transcription factors, including C/EBP , AP-1, Sp-1, SRF , STAT6 and SEF

Go back
713.0, 1227.0
23.0, 23.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e115 e16

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m119*m16*0.1

nodelay

--

true

0

false

PMID: 17349209, 16143103 NF-¦ÊB has been shown to directly interact with TRIF-activated IRF3 on target promoters.

Go back
874.0, 1524.0
21.0, 21.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e42

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c254 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17349209, 15241416 I¦ÊB¦Æ is itself a TLR inducible gene which associates with p50 and is critical for the induction of the pro-inflammatory cytokines IL-6 and IL-12 following TLR stimulation in macrophages.

Go back
815.0, 1267.0
17.0, 17.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 17349209 The degradation of I¦ÊB protein allows for translocation of the liberated NF-¦ÊB dimers to the nucleus where they bind their cognate sites in DNA and activate gene transcription.

Go back
1085.0, 1593.0
21.0, 21.0

p90

p90

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010262 e42

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c258 : 1
stoichiometry:c257 : 1

m93248*m42*0.1

nodelay

--

true

0

false

PMID: 17349209, 15241416 I¦ÊB¦Æ is itself a TLR inducible gene which associates with p50 and is critical for the induction of the pro-inflammatory cytokines IL-6 and IL-12 following TLR stimulation in macrophages.

Go back
849.0, 1563.0
23.0, 23.0

p91

p91

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e42

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c260 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17349209, 15241416 I¦ÊB¦Æ is itself a TLR inducible gene which associates with p50 and is critical for the induction of the pro-inflammatory cytokines IL-6 and IL-12 following TLR stimulation in macrophages.

Go back
1034.0, 1668.0
21.0, 21.0

p92

p92

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e126 e42

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c263 : 1
stoichiometry:c259 : 1

m131*m42*0.1

nodelay

--

true

0

false

PMID: 17349209, 15241416 I¦ÊB¦Æ is itself a TLR inducible gene which associates with p50 and is critical for the induction of the pro-inflammatory cytokines IL-6 and IL-12 following TLR stimulation in macrophages.

Go back
866.0, 1316.0
21.0, 21.0

p93

p93

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e13

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17349209 The de novo synthesis of the I¦ÊB proteins in an NF-¦ÊB-dependent manner constitutes a negative feedback loop for NF-¦ÊB activity.

Go back
452.0, 1242.0
25.0, 25.0

p94

p94

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e127

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1

m132*0.1

nodelay

--

true

0

false

PMID: 17349209 The de novo synthesis of the I¦ÊB proteins in an NF-¦ÊB-dependent manner constitutes a negative feedback loop for NF-¦ÊB activity.

Go back
466.0, 1618.0
24.0, 24.0

p95

p95

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e128

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c268 : 1
stoichiometry:c269 : 1

m133*0.1

nodelay

--

true

0

false

PMID: 17349209, 15900032 Newly synthesized I¦ÊB proteins enter the nucleus via a nuclear localization signal where they bind free NF-¦ÊB dimers and translocate to the cytoplasm as an I¦ÊB/NF-¦ÊB complex using a nuclear export sequence, thereby terminating NF-¦ÊB transcriptional activity

Go back
762.0, 1620.0
21.0, 21.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e129 e13

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c271 : 1
stoichiometry:c272 : 1

m134*m13*0.1

nodelay

--

true

0

false

PMID: 17349209, 15900032 Newly synthesized I¦ÊB proteins enter the nucleus via a nuclear localization signal where they bind free NF-¦ÊB dimers and translocate to the cytoplasm as an I¦ÊB/NF-¦ÊB complex using a nuclear export sequence, thereby terminating NF-¦ÊB transcriptional activity

Go back
783.0, 1637.0
27.0, 27.0

p97

p97

cso30:i:ME_NuclearExport

cso30:i:CC_Cytoplasm

--

e130

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c273 : 1
stoichiometry:c274 : 1

m135*0.1

nodelay

--

true

0

false

PMID: 17349209, 15900032 Newly synthesized I¦ÊB proteins enter the nucleus via a nuclear localization signal where they bind free NF-¦ÊB dimers and translocate to the cytoplasm as an I¦ÊB/NF-¦ÊB complex using a nuclear export sequence, thereby terminating NF-¦ÊB transcriptional activity

Go back
941.0, 1247.0
23.0, 23.0

p98

p98

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytoplasm

--

e16

e132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c276 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 17349209, 15226358 The second mechanism of limiting NF-¦ÊB activity was initially discovered in studies of I¦ÊB¦Á knockout cells and involves the ubiquitin targeted proteasomal degradation of promoter bound NF-¦ÊB.

Go back
1097.0, 1323.0
23.0, 23.0

p99

p99

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e132

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1

m137*0.1

nodelay

--

true

0

false

PMID: 17349209, 15226358 The second mechanism of limiting NF-¦ÊB activity was initially discovered in studies of I¦ÊB¦Á knockout cells and involves the ubiquitin targeted proteasomal degradation of promoter bound NF-¦ÊB.

Go back
662.0, 391.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.0, 755.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 104.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 240.46803758429948

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 204.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.9425724154552, 202.29054671057938

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1038.4256292582156, 113.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1142.0, 204.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1114.0, 236.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0308274533255, 188.81673490323388

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.0, 196.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 255.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.0, 755.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.2541450602852, 207.77511991082454

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1263.0, 118.78063113323532

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1295.6564023547028, 77.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1281.0, 111.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1238.0, 127.13136511471608

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1319.0, 128.65685424949237

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1356.0056408699138, 123.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1359.0, 127.45947350307215

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.0, 121.64187677750958

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1403.46701094872, 126.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.0, 755.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1408.0, 251.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1339.0, 77.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1412.3865295666617, 258.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1406.0, 311.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1238.0, 239.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1414.4470545031274, 320.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1408.0, 367.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.0, 255.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1409.8335884449154, 373.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.5347985803924, 102.17671226928152

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.4788592902239, 766.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.271030765326, 95.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
707.3548626638176, 60.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
642.0816153065192, 105.8804372309896

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.4759018794317, 96.8479626207359

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.3995009355511, 99.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.8383414700477, 97.78591681431949

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.50220645841, 90.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.0, 64.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.88135505504476, 105.42306764815815

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.74315214231495, 96.01086919041569

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.4341419219418, 766.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.0, 101.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.34640108602343, 96.26647092965086

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
381.0, 89.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.0, 79.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
258.9895013078127, 180.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
251.0, 192.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.97541423406113, 188.62671189164993

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1334.0, 467.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1042.0, 187.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1412.6144659505665, 470.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.0, 967.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1405.0, 507.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1290.0, 589.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1338.0, 539.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1407.5894663844042, 542.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1297.9488420383177, 576.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1411.0, 619.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1336.0, 621.2350150421888

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1412.960177486789, 624.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1406.0, 685.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1409.1972533026424, 704.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 1062.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1402.0, 748.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1414.4782686447068, 780.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.9901107455318, 776.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1407.0, 812.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1409.0, 863.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1327.0, 824.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1401.0, 866.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1322.0, 865.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1309.0, 920.1930472179772

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1254.0, 873.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.0, 1150.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1413.8716110312748, 922.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1406.0, 962.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1326.0, 995.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1410.734445130114, 998.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1403.0, 1045.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1413.8550669730648, 1077.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1042.0, 665.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.1808595010743, 710.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.1705280513365, 716.1045589251264

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1126.0, 855.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.0, 1211.8883650844857

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.79279858428, 905.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1165.2304138308937, 908.0181613660592

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1179.0, 1149.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1206.6379617782632, 1172.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1225.4560373723305, 1096.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
728.4167787461936, 198.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 256.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.99756913242805, 283.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.6625609418811, 202.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 255.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.2625061574892, 1204.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.98706914285265, 316.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1207.8193133235188, 1221.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.0, 266.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.0, 1272.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1408.0, 1437.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1414.0343357322943, 1465.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1322.7396721814491, 1503.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 672.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.0, 1528.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.0, 265.0626638893168

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.0, 391.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
838.5631853341599, 1248.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
350.5845097641281, 272.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 380.05427713547755

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0, 413.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0, 468.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.0, 295.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1154.1554175279994, 1218.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.808987532707, 1307.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.7157525604754, 1383.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.0, 1441.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.320056722406, 368.0

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
832.0, 1280.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.0, 425.76114000116263

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1153.151825073934, 374.83830012177384

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1144.0, 204.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
993.0, 1486.6208448322877

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1013.4246907579123, 1493.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.6568542494924, 1466.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.0, 1501.3099343641636

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.9993426188411, 1494.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.3501780205493, 1505.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.3897804297072, 1383.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 706.8208100192876

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.0769230769231, 1445.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.0, 642.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
953.9924492668405, 1368.3474977942105

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.9412711149687, 1378.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1005.0, 1322.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
791.3995009355511, 476.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
974.0, 1242.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.0497011787119, 1223.7329635378674

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.0, 1317.1892378714983

c229

c229

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
467.01731452788295, 642.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.629976047529, 1157.5240571578818

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 1054.8571555701683

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
910.0, 1154.986787291746

c232

c232

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
576.724568280749, 1265.3336106698162

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0491401380352, 1144.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.3929676735984, 1264.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.4630710245168, 1148.0

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.4788592902239, 1387.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 1379.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.3251245132185, 1143.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.795129565557, 659.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.2636750760037, 1399.352465419694

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.0, 1401.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.0, 1236.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.7037121577134, 1483.1570394041598

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 1487.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.4521992568291, 1137.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
758.613571991078, 1303.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.0, 1339.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.9899522102519, 1150.0

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 1530.0

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.47254624603545, 700.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.8995250553337, 1522.2639240088533

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.6016999533429, 1150.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 1239.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 1212.1877316447983

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 1540.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 1289.0

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
956.0, 1564.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1106.0, 1605.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 1284.0

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1055.0, 1679.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.0, 651.2579303520877

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 1581.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
956.0, 1628.0

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 1292.0

c262

c262

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
679.0, 1288.0

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.0, 1150.0

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.0, 1337.0

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.5752835663473, 1261.571979566293

c266

c266

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.6636527173945, 1216.1117964514128

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
434.0, 1213.0

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 1630.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 654.6275716545526

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.0, 1631.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.6329648238252, 1150.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.0, 1605.4057970281387

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.7540371932674, 1607.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
798.0, 621.9549719655214

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
907.0, 1247.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.0, 1270.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.0, 1313.0

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1109.0, 1346.0

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1011.0, 1383.0

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 651.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
989.6615021863596, 1428.0

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.0, 788.0

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
993.0, 1494.0

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1082.0, 1444.2455218124676

c283

c283

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.796029752168, 1219.0

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1030.0, 1262.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 785.0

c286

c286

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1056.0, 1267.2080133580728

c287

c287

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.0, 1260.0

c288

c288

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1057.547454959643, 197.0

c289

c289

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.0, 655.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.9227973930566, 321.0

c290

c290

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.0, 338.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.2648867799863, 314.9750571488127

c292

c292

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.9985696486026, 303.15127318484355

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.6507117267404, 306.0

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.7709926620733, 373.0

c295

c295

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.66782285332891, 572.0

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.2805291210643, 279.9950799503341

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
193.0, 321.33452749598797

c298

c298

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0, 373.0

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 371.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
417.0, 593.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 924.7750142330225

c300

c300

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
717.0, 925.0

c301

c301

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.0, 313.0

c302

c302

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
205.8357882592728, 614.6125825113286

c303

c303

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1397.0, 884.0

c304

c304

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1405.5176854711858, 831.5935011600828

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 702.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1407.0, 810.0

c307

c307

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1407.0, 818.0

c308

c308

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
216.76256170793184, 581.0

c309

c309

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.1723892887157, 665.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
218.88881466290184, 699.3291362662966

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.82605358927165, 699.659182093035

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.72656926820935, 701.073674840365

c312

c312

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.0, 705.0

c313

c313

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.20600533337415, 314.0

c314

c314

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
638.0286699331288, 553.0

c315

c315

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 1133.0

c316

c316

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.0, 1237.0

c317

c317

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
650.9592937412584, 1250.0

c318

c318

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.1756560418075, 407.0

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 581.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.45397833417405, 508.90485920375903

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1411.0, 1166.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1496.907883951425, 1176.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1416.9320762448115, 1208.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.1150812903371, 576.1580791785867

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1413.0, 1302.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1478.9764358840127, 1347.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 381.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1415.9439061935595, 1351.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.60245808999866, 569.5174713247359

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.8995700892396, 520.4560373723303

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0201940420826, 572.268516270799

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.0, 1139.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.383083722649, 1136.2494651199622

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.8872359984509, 672.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.57680809740106, 985.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 1091.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 1160.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
459.0, 748.2868259682745

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 1153.7486522501083

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 1165.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
711.0, 1139.24

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.145770236779, 1080.121475197316

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 1067.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 823.8287995490302

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
663.5823947831562, 731.5575649483098

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 836.5445442660432

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 986.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.0, 967.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0, 714.2164574740316

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.0, 982.8678007676015

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
488.0, 571.1876095393344

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 575.9488420383177

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
901.0, 906.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.9792745494693, 901.3149107106393

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.0, 887.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.0, 1023.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 1032.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.0, 938.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 947.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.2346363266411, 614.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 919.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 956.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.3995222713548, 991.0408995635705

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 915.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 994.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.0, 1389.0950515759703

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1243.8700853921453, 1389.4352642519864

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1230.0, 1385.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.8366331753298, 1303.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.9822812628529, 1384.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 688.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.0, 1370.9796695986458

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.2089120009301, 1391.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.9459451369956, 1419.9691115068547

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 1420.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.9796695986458, 1297.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.8482000770675, 1319.0136549791714

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.4, 1288.8

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.0, 1436.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.0, 1454.6568542494924

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 1407.9195959492893

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.0, 681.0842423725038

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1159.0, 76.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1206.0, 125.99276672546496

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1159.532571993008, 118.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1151.0, 204.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1183.0, 235.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.4307351936247, 194.75874404328235

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1061.383083722649, 120.24946511996212

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 121.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.2065767803005, 110.8047565563683

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.1916583936265, 70.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back