1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17379560.csml convertedTime:2009.07.01.11:02

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Role of Nods in bacterial infection.
Authors Bourhis LL, Werts C.
Affiliation Innate Immunity and Signalisation, Institut Pasteur, 28, Rue du Dr. Roux, 75724Paris Cedex 15, France.
Abstract Research into intracellular sensing of microbial products is an up and comingfield in innate immunity. Nod1 and Nod2 are members of the rapidly expandingfamily of NACHT domain-containing proteins involved in intracellular recognitionof bacterial products. Nods proteins are involved in the cytosolic detection ofpeptidoglycan motifs of bacteria, recognized through the LRR domain. The role ofthe NACHT-LRR system of detection in innate immune responses is highlighted atthe mucosal barrier, where most of the membranous Toll like receptors (TLRs) arenot expressed, or with pathogens that have devised ways to escape TLR sensing.For a given pathogen, the sum of the pathways induced by the recognition of thedifferent "pathogen associated molecular patterns" (PAMPs) by the differentpattern recognition receptors (PRRs) trigger and shape the subsequent innate andadaptive immune responses. Knowledge gathered during the last decade on PRR andtheir agonists, and recent studies on bacterial infections provide new insightsinto the immune response and the pathogenesis of human infectious diseases.
PMID 17379560
Model Abstract

Entity

MO000000058:NF-kappaB MO000000248:IKK MO000016574:TAK1 MO000016597:IL-1beta MO000016599:IKK-gamma MO000016828:Caspase-1 MO000017601:Caspase-5 MO000017811:proCaspase-9 MO000017949:RIP2 MO000018229:proCaspase-1 MO000019449:proIL-1beta MO000020434:Nod1 MO000020461:Nod2 MO000022224:dsRNA MO000034305:Erbin MO000044014:ASC MO000061988:TRIP6 MO000066987:DDX58 e1: e10: e11:muramyl dipeptide:Nod2 e12:diaminopimelic acid e13:diaminopimelic acid:Nod1 e14:Mda5 e15:dsRNA:Mda5 e16: (diaminopimelic acid:Nod1)2 e17: (diaminopimelic acid:Nod1)2 :RIP2 e18:(muramyl dipeptide:Nod2)2 e19:(muramyl dipeptide:Nod2)2: RIP2 e2: e20: (diaminopimelic acid:Nod1)2 :RIP2:IKK e21:IKK-gamma{ub} e22:procaspase-9:Nod1 e23:inflammosome e24:NALP e25:DPA:Nod1:RIP2:procaspase-1 e26:Nalp3 e27:MDP:Nalp3 e28:inflammosome{active} e29:Rip2:TRIP6 e3: e30:TAK1:Nod2 e31:NF-kappaB{active} e32:Nod2:Erbin e4: e5:dsRNA:DDX58 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:muramyl dipeptide e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p3 p4 p5 p6 p7 p8 p9
Model Detail
163.0, 759.0
34.0, 34.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
835.0, 583.0
26.0, 26.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
435.0, 139.0
34.0, 34.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1059.0, 883.0
34.0, 34.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
190.0, 322.0
28.0, 28.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
467.0, 759.0
34.0, 34.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
571.0, 687.0
33.0, 33.0

Caspase-5

--

MO000017601

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m2380

10

false

infinite

0

unit false false false
TRANSPATHMO000017601

--

Go back
769.0, 349.0
30.0, 30.0

proCaspase-9

--

MO000017811

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m2563

10

false

infinite

0

unit false false false
InterProIPR001309
TRANSPATHMO000017811

--

Go back
426.0, 426.0
27.0, 27.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p8 p10 p14 p17

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
397.0, 509.0
29.0, 29.0

proCaspase-1

--

MO000018229

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m2906

10

false

infinite

0

unit false false false
InterProIPR001309
TRANSPATHMO000018229

--

Go back
773.0, 793.0
38.0, 38.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
556.0, 384.0
32.0, 32.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p11

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
485.0, 237.0
38.0, 38.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p18 p20

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
203.0, 591.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
571.0, 131.0
34.0, 34.0

Erbin

--

MO000034305

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m12851

10

false

infinite

0

unit false false false
InterProIPR003591
TRANSPATHMO000034305

--

Go back
652.0, 692.0
32.0, 32.0

ASC

--

MO000044014

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m21736

10

false

infinite

0

unit false false false
InterProIPR004020
TRANSPATHMO000044014

--

Go back
485.0, 361.0
30.0, 30.0

TRIP6

--

MO000061988

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m36881

10

false

infinite

0

unit false false false
TRANSPATHMO000061988

--

Go back
295.0, 491.0
34.0, 34.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
58.545756662856775, 20.750949420673038
954.9761235871966, 1386.6253314486075

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
60.7468851208169, 100.94487554267812
925.6643027336419, 1302.1493914273603

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
739.5, 263.8265731199298
25.406270554702914, 49.17342688007016

muramyl dipeptide:Nod2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
755.0, 385.4617325483598
50.361648444070646, 28.53826745164003

diaminopimelic acid

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
652.5, 438.0
31.0, 60.0

diaminopimelic acid:Nod1

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p5 p14

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
147.0, 671.4979875226402
42.165425638961565, 26.00201247735963

Mda5

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
341.0, 667.5193370165746
30.13259668508287, 33.48066298342542

dsRNA:Mda5

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
811.0, 453.58823529411757
26.647058823529413, 44.41176470588235

(diaminopimelic acid:Nod1)2

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
672.0, 575.5588235294118
24.264705882352935, 40.44117647058824

(diaminopimelic acid:Nod1)2 :RIP2

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
440.0, 285.05882352941177
31.764705882352935, 52.94117647058824

(muramyl dipeptide:Nod2)2

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
313.0, 303.47058823529414
29.117647058823533, 48.529411764705884

(muramyl dipeptide:Nod2)2: RIP2

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p10

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
58.545756662856775, 20.750949420673038
954.9761235871966, 1386.6253314486075

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
782.0, 648.5
28.500000000000004, 47.5

(diaminopimelic acid:Nod1)2 :RIP2:IKK

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
142.0, 475.55423372988116
43.62491252624213, 33.445766270118966

IKK-gamma{ub}

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p19

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
795.5, 300.7950341609731
24.66738876853858, 30.204965839026833

procaspase-9:Nod1

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
648.0, 787.7058823529413
24.17647058823529, 40.29411764705883

inflammosome

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p16

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
490.0, 696.571040450795
35.56047494465686, 21.928959549205075

NALP

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
535.0, 594.1764705882354
26.294117647058822, 43.82352941176471

DPA:Nod1:RIP2:procaspase-1

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p12

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
626.5, 105.6105856309116
27.990138860937815, 45.38941436908836

Nalp3

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
845.0, 218.74585635359125
30.828729281767956, 34.25414364640883

MDP:Nalp3

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
695.0, 930.9411764705881
25.235294117647058, 42.05882352941177

inflammosome{active}

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p12

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
558.5, 454.9156807198799
27.835527412097985, 34.08431928011999

Rip2:TRIP6

--

e29

cso30:c:Complex

cso30:i:CC_Extracellular

--

p17

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
77.64527913460063, 39.85047189241703
916.7770786437088, 1348.4262865051205

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
309.0, 183.6850828729281
29.983425414364646, 33.31491712707183

TAK1:Nod2

--

e30

cso30:c:Complex

cso30:i:CC_Extracellular

--

p18

p19

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
163.0, 911.0
34.0, 34.0

NF-kappaB{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
506.5, 135.19546742209627
26.79036827195467, 32.804532577903686

Nod2:Erbin

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p19

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
112.97939570732717, 73.27463621796872
846.1088454982565, 1281.5779578540162

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
352.5, 564.1864689218463
31.6977170471588, 38.81353107815364

dsRNA:DDX58

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
211.6917606634948, 836.4161075009976
448.7586780689672, 406.97481605137267

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
260.1610406039045, 846.0608189930942
262.4026534704948, 394.4396574460942

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
217.5415013459579, 841.8480095632848
437.0591967040406, 396.11101192679786

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
218.37717858630992, 842.683686803637
435.3878422233367, 394.4396574460942

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
211.6917606634948, 836.4161075009976
448.7586780689672, 406.97481605137267

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
211.6917606634948, 836.4161075009976
448.7586780689672, 406.97481605137267

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
218.37717858630992, 842.683686803637
435.3878422233367, 394.4396574460942

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
539.2772388814374, 1003.5515555713773
28.035976499364224, 25.37993662047711

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
465.7376417304704, 1120.5463692206422
79.38933783342986, 71.86824267026296

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
211.6917606634948, 836.4161075009976
448.7586780689672, 406.97481605137267

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
721.0, 168.54583683767862
53.74264087468461, 30.45416316232128

muramyl dipeptide

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1 p15

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
317.4616560930682, 1017.2723528936374
14.211527952830751, 6.8425875328444485

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
316.98709294783356, 996.8661376485604
48.6427223865206, 87.55690029573712

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
337.3933081929108, 1053.8137150766822
7.59301032374955, 7.593010323749552

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
71.0927500146206, 26.330839371594323
936.5340556972877, 1327.0445660064893

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
74.43861490842431, 49.75189362821999
898.42827915516, 1304.5178613332916

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
83.36092129190064, 73.17294788484563
894.3264612420056, 1287.4094364645052

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
621.0, 245.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000020461

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c1 : 1
stoichiometry:c3 : 1

m6*m4947*0.1

nodelay

--

true

0

false

PMID: 17379560, 12527755, 12514169 Nod2 senses both Gram-negative and Gram-positive bacteria since it recognizes MDP.

Go back
201.0, 388.5
22.5, 22.5

p10

p10

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016599 e19 MO000017949

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c27 : 1

m1593*m19*m2684*0.1

nodelay

--

true

0

false

PMID: 17379560, 15620648 Activation of Nod2 has been shown to induce a RIP2-dependent ubiquitinylation of NEMO (IKK¦Ã), at a novel site, resulting in enhanced NF-¦ÊB signaling

Go back
637.0, 337.0
21.0, 21.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020434 MO000017811

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m4923*m2563*0.1

nodelay

--

true

0

false

PMID: 17379560, 10329646 Nod1 has been shown to bind to pro-caspase 9, through homophilic CARD-CARD interactions and up-regulate caspase-9 induced apoptosis.

Go back
780.0, 888.0
23.0, 23.0

p12

p12

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

MO000019449 e25 e28

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c45 : 1
stoichiometry:c51 : 1
stoichiometry:c34 : 1

m4012*m25*m28*0.1

nodelay

--

true

0

false

PMID: 17379560 pro-IL-1? processing and IL-1? secretion relies on cleavage of pro-IL-1? by caspase-1. This process takes place in a protein complex recently described as the ¡Èinflammasome¡É.

Go back
577.0, 765.5
21.5, 21.5

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016828 MO000017601 MO000044014 e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c37 : 1

m1765*m2380*m21736*m24*0.1

nodelay

--

true

0

false

PMID: 17379560, 12191486 The ¡Èinflammasome¡É comprises of caspase-1 and -5, the adaptor protein ASC, which bears a CARD and a PYRIN domain, and several members from the Nalp family, which are NACHT proteins bearing both a PYRIN and a LRR domain.

Go back
479.0, 531.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017949 MO000018229 e13

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m2684*m2906*m13*0.1

nodelay

--

true

0

false

PMID: 17379560, 12459189 Nod1 enhances pro-interleukin-1? processing through heterophilic CARD-CARD interactions between Nod1, RIP2 and pro-caspase-1.

Go back
630.0, 174.5
19.5, 19.5

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 e6

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m26*m6*0.1

nodelay

--

true

0

false

PMID: 17379560, 15530394 It has also been published that MDP can activate the inflammasome through binding to Nalp3 (cryopyrin).

Go back
671.0, 871.5
17.5, 17.5

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c50 : 1
stoichiometry:c49 : 1

m23*m27*0.1

nodelay

--

true

0

false

PMID: 17379560, 15530394 It has also been published that MDP can activate the inflammasome through binding to Nalp3 (cryopyrin).

Go back
489.0, 421.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000061988 MO000017949

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m36881*m2684*0.1

nodelay

--

true

0

false

PMID: 17379560, 15657077 TRIP-6, a LIM-domain containing protein, can potentiate Nod1 activation, most likely through its interaction with RIP2.

Go back
441.0, 197.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000020461 MO000016574

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m4947*m1573*0.1

nodelay

--

true

0

false

PMID: 17379560, 15075345 TAK1 and Nod2 have been shown to interact through the LRR domain of Nod2 and to reciprocally negatively regulate NF-¦ÊB activation.

Go back
237.0, 817.0
21.0, 21.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e30 e32 e21

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c59 : 1

m31*m21*0.1

nodelay

--

true

0

false

PMID: 17379560, 15075345 TAK1 and Nod2 have been shown to interact through the LRR domain of Nod2 and to reciprocally negatively regulate NF-¦ÊB activation. PMID: 17379560, 16714539, 16203728 ERBIN appears to be a negative regulator of Nod2 dependent NF-¦ÊB and MAP kinases signaling PMID: 17379560, 15620648 More recently, activation of Nod2 has been shown to induce a RIP2-dependent ubiquitinylation of NEMO (IKKg), at a novel site, resulting in enhanced NFkB signaling

Go back
658.0, 390.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020434 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m4923*m12*0.1

nodelay

--

true

0

false

PMID: 17379560, 12791997 Nod1, in contrast, has a narrow specificity and recognizes only diaminopimelic acid (DAP) type PG.

Go back
541.0, 201.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020461 MO000034305

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m4947*m12851*0.1

nodelay

--

true

0

false

PMID: 17379560 ERBIN, a member of the LAP (LRR and PDZ domain) protein family involved in cell polarity, as a new binding partner of Nod2.

Go back
301.0, 573.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 MO000022224

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m41844*m119368*0.1

nodelay

--

true

0

false

PMID: 17379560 Very recently RIG-I and MDA-5 helicases have been shown to be intracellular sensors of viral double strand RNA.

Go back
266.0, 674.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m119368*m14*0.1

nodelay

--

true

0

false

PMID: 17379560 Very recently RIG-I and MDA-5 helicases have been shown to be intracellular sensors of viral double strand RNA.

Go back
723.0, 467.0
17.0, 17.0

p5

p5

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e13

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).

Go back
569.0, 522.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017949 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m2684*m16*0.1

nodelay

--

true

0

false

PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).

Go back
600.0, 300.0
23.0, 23.0

p7

p7

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e11

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).

Go back
384.0, 300.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000017949

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m18*m2684*0.1

nodelay

--

true

0

false

PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).

Go back
781.0, 584.5
22.5, 22.5

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000000248

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m17*m207*0.1

nodelay

--

true

0

false

PMID: 17379560, 11463746 Upon Nod1 activation, a transient interaction between Nod1, RIP2 and IKKs occurs, which is suggestive of a mechanism of down-regulation.

Go back
523.0, 256.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.0, 617.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0, 684.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 684.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0, 470.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 476.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 449.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.7873373466687, 479.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 539.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.8856185318273, 290.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
480.0, 312.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.7932784947899, 199.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.0, 312.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.57390343144993, 330.5746300982669

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.78244971748296, 315.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 596.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 596.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.0, 607.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
206.0, 350.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
176.62153887821785, 411.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
230.77113291357844, 337.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
231.87590208986984, 403.4036261150263

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
642.0, 259.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 360.46880303583254

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.9456923689366, 349.9305765837493

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 320.53609285108524

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 831.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.0, 900.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 776.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 720.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 781.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.0983526333521, 722.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 719.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 400.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 828.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 453.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 528.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.35060612650716, 475.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 556.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 631.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 151.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 184.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 186.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0, 889.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 400.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.1533456592902, 253.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
720.0, 911.1991096239717

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
500.0, 391.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 434.1005469701975

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.0, 437.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.907883951425, 222.39415491217065

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.0, 173.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.98619498539995, 201.46977617561177

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
197.0, 789.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.45857750013488, 838.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 409.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.48310416021963, 217.0

c60

c60

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
523.0, 227.31491071063937

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.885143449429, 165.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.8308170454446, 175.02316458331507

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.4973797063385, 168.0

c64

c64

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
168.0, 509.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.0, 525.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
229.0, 587.631634032896

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
322.0, 584.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back