1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17395579.csml convertedTime:2009.07.01.11:02

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Innate immunity minireview series: making biochemical sense of nucleic acidsensors that trigger antiviral innate immunity.
Authors Samuel CE.
Affiliation Department of Molecular, Cellular, and Developmental Biology and theBiomolecular Sciences and Engineering Program, University of California, SantaBarbara, California 93106, USA. samuel@lifesci.ucsb.edu
Abstract
PMID 17395579
Model Abstract

Entity

e1: e10: e11: e12:TLR7 e13:TLR8 e14:TLR9 e15:ssRNA: TLR7 e16:ssRNA: TLR8 e17:CpG DNA: TLR9 e18:ssRNA: TLR7: MyD88 e19:ssRNA: TLR8: MyD88 e2: e20:CpG DNA: TLR9: MyD88 e21:MyD88 e22:ssRNA e23:CpG DNA e24:dsRNA e25:TLR3 e26:dsRNA: TLR3 e27:TRIF e28:dsRNA: TLR3: TRIF e29:RIG-1 e3: e30:Mda-5 e31:dsRNA: RIG-1 e32:dsRNA: Mda-5 e33: e34: e35: e36: e37: e38: e39: e4: e40: e41: e42:IPS-1 e43:dsRNA: RIG-1: IPS-1 e44:dsRNA: Mda-5: IPS-1 e45:TRAF3 e46:TRAF3{activated} e47:TBK-1: IKK-i e48:TBK-1: IKK-i{activated} e49:IRF-3 e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:IRF-3{activated} e64:IRF-7 e65:IRF-7{activated} e66:IKK-alpha: IKK-beta: IKK-gamma e67:IKK-alpha: IKK-beta: IKK-gamma{activated} e68:NF-kappaB e69:NF-kappaB{activated} e7: e70:IRAK1: IRAK4 e71:IRAK1: IRAK4{activated} e72:TRAF6 e73:TRAF6{activated} e74:IRF-3: IRF-7 {activated} e75:IRF-3: IRF-7 {nuclear} e76:IFN-beta e77:NF-kappaB{nucleus} e78:IFN-alpha4 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p4 p5 p6 p7 p8 p9
Model Detail
136.71883200970828, 44.16835497435244
757.2965886848164, 1099.5946467703525

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
150.01533191285765, 60.97514998902062
734.052298704921, 1032.6051800978976

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
306.20649308781975, 208.5057554093263
245.46318244742352, 409.7987028995123

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
471.5, 221.0
24.217926186291734, 37.258347978910365

TLR7

--

e12

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
539.375, 364.5
22.55579964850615, 34.70123022847099

TLR8

--

e13

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
510.375, 514.5
25.800087873462214, 39.69244288224956

TLR9

--

e14

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
508.375, 265.5
23.25, 45.0

ssRNA: TLR7

--

e15

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p1

p2

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
540.375, 409.5
23.25, 45.0

ssRNA: TLR8

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
482.375, 544.5
20.14388292041219, 38.98816049112037

CpG DNA: TLR9

--

e17

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p4

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
529.875, 315.5
26.15787300422096, 36.49935768030831

ssRNA: TLR7: MyD88

--

e18

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p2

p19

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
526.875, 461.5
26.757616076344284, 37.33620847861993

ssRNA: TLR8: MyD88

--

e19

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p5

p20

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
136.71883200970828, 44.16835497435244
757.2965886848164, 1099.5946467703525

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
433.875, 583.5
26.82863828225362, 37.43530923105157

CpG DNA: TLR9: MyD88

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p21

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
668.25, 413.5
15.87605238540692, 36.637043966323674

MyD88

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2 p5 p6

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
78.375, 368.5
24.48018867924528, 26.705660377358488

ssRNA

--

e22

cso30:c:RnaOther

cso30:i:CC_Cytosol

--

--

p1 p3

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
69.5, 556.125
45.0, 15.75

CpG DNA

--

e23

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
74.375, 165.5
26.306603773584904, 28.69811320754717

dsRNA

--

e24

cso30:c:RnaOther

cso30:i:CC_Extracellular

--

--

p7 p9 p10

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
311.375, 224.5
23.149824253075572, 35.61511423550088

TLR3

--

e25

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p7

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
305.375, 278.5
19.987557553168163, 38.685595264196444

dsRNA: TLR3

--

e26

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p7

p8

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
216.25, 277.5
14.319457436856878, 33.04490177736203

TRIF

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
303.875, 329.5
29.472242613323544, 41.12405946045146

dsRNA: TLR3: TRIF

--

e28

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

p17 p13

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
212.375, 133.5
23.789543057996486, 36.59929701230229

RIG-1

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
151.86476378340458, 59.314286748048815
727.0047251374239, 1069.3027832229607

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
212.375, 185.5
23.423989455184536, 36.03690685413005

Mda-5

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
284.375, 109.5
23.25, 45.0

dsRNA: RIG-1

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
284.375, 157.5
23.25, 45.0

dsRNA: Mda-5

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p12

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
702.9216068642745, 197.0185257410293
11.650869808377207, 20.97156565507892

--

e33

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false true false

--

Go back
707.6956218101459, 210.54490142099883
1.8186723603320503, 1.8186723603320474

--

e34

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false true false

--

Go back
652.6602964118564, 106.03529641185642
134.5772230889231, 187.91575663026458

--

e35

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false true false

--

Go back
652.6602964118564, 106.03529641185642
134.5772230889231, 187.91575663026458

--

e36

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false true false

--

Go back
652.6602964118564, 106.03529641185642
134.5772230889231, 187.91575663026458

--

e37

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false true false

--

Go back
669.0721528861153, 120.1905226209048
101.75351014040535, 159.60530421216805

--

e38

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false true false

--

Go back
652.25, 105.625
135.39781591263605, 188.7363494539775

--

e39

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false true false

--

Go back
179.88473756474295, 85.81966735201718
670.9647775747475, 1016.2920220150227

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
669.482449297972, 120.6008190327613
100.93291731669242, 158.78471138845504

--

e40

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false true false

--

Go back
669.482449297972, 120.6008190327613
100.93291731669242, 158.78471138845504

--

e41

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false true false

--

Go back
644.25, 150.5
15.450420954162768, 35.65481758652947

IPS-1

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11 p12

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
662.875, 113.5
26.418287759221876, 36.862727105891

dsRNA: RIG-1: IPS-1

--

e43

cso30:c:Complex

cso30:i:CC_MitochondrialIntermembraneSpace

--

p11

p28

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
638.875, 197.5
26.22100385391815, 36.58744723802533

dsRNA: Mda-5: IPS-1

--

e44

cso30:c:Complex

cso30:i:CC_MitochondrialIntermembraneSpace

--

p12

p27

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
218.125, 419.5
19.73792513584222, 32.00744616623063

TRAF3

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13 p27 p28

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
218.125, 463.5
19.73792513584222, 32.00744616623063

TRAF3{activated}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p13 p27 p28

p14

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
214.625, 515.5
27.131269788368606, 33.22196300616564

TBK-1: IKK-i

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
266.625, 587.5
27.131269788368606, 33.22196300616564

TBK-1: IKK-i{activated}

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15 p16

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
229.5, 665.125
36.088750251559674, 22.25472932179513

IRF-3

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
306.20649308781975, 208.5057554093263
245.46318244742352, 409.7987028995123

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
408.36933800336163, 773.8428814551356
306.48359160823594, 277.9469443448997

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
441.4718488288321, 780.4298199648101
179.2101448137545, 269.3859501658986

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
412.3644686202288, 777.5526455993695
298.49333037450197, 270.527416056432

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
412.9352015654954, 778.1233785446361
297.3518644839683, 269.3859501658986

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
408.36933800336163, 773.8428814551356
306.48359160823594, 277.9469443448997

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
408.36933800336163, 773.8428814551356
306.48359160823594, 277.9469443448997

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
412.9352015654954, 778.1233785446361
297.3518644839683, 269.3859501658986

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
632.0966525479212, 887.9894705084827
19.147410828339922, 17.333445591970904

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
581.8721533644488, 967.8920828458251
54.2196298003397, 49.08303329293919

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
408.36933800336163, 773.8428814551356
306.48359160823594, 277.9469443448997

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
306.20649308781975, 208.5057554093263
245.46318244742352, 409.7987028995123

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
480.6057960809505, 897.3602068275004
9.705885015899407, 4.673203896544168

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
480.28168910697013, 883.4236069463485
33.22096483297874, 59.79773669936176

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
494.2182889881225, 922.3164438239827
5.185711583684481, 5.185711583684487

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
229.5, 705.125
36.088750251559674, 22.25472932179513

IRF-3{activated}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p15

p24

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
406.5, 669.125
34.91748842825519, 21.532451197424027

IRF-7

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16 p23

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
406.5, 725.125
34.91748842825519, 21.532451197424027

IRF-7{activated}

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16 p23

p24

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
551.875, 653.5
32.25, 45.0

IKK-alpha: IKK-beta: IKK-gamma

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
551.875, 709.5
32.25, 45.0

IKK-alpha: IKK-beta: IKK-gamma{activated}

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
670.5, 659.125
35.56000000000001, 26.669999999999995

NF-kappaB

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
670.5, 711.125
35.56000000000001, 26.669999999999995

NF-kappaB{activated}

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p29

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
152.668604604912, 48.59321075943379
742.6720187543552, 1052.347067164843

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
765.625, 414.5
28.07027995334111, 34.37177137143809

IRAK1: IRAK4

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p19 p20 p21

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
769.625, 494.5
28.07027995334111, 34.37177137143809

IRAK1: IRAK4{activated}

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19 p20 p21

p22

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
794.125, 563.5
20.452757093982694, 33.16663312537734

TRAF6

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
794.125, 611.5
20.452757093982694, 33.16663312537734

TRAF6{activated}

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
313.625, 814.5
28.870479920013338, 35.351608065322445

IRF-3: IRF-7 {activated}

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
497.625, 814.5
28.870479920013338, 35.351608065322445

IRF-3: IRF-7 {nuclear}

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26 p31

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
511.5, 929.0
40.017301038062286, 21.342560553633216

IFN-beta

--

e76

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26 p30

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
614.5, 811.125
35.56000000000001, 26.669999999999995

NF-kappaB{nucleus}

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

p30 p32

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
593.5, 926.0
36.79930795847751, 19.62629757785467

IFN-alpha4

--

e78

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31 p32

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
155.3218772969663, 67.16611960381401
712.4541171002888, 1034.4833780296196

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
162.3972711424445, 85.73902844819426
709.2013732501392, 1020.916387744841

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
407.0, 227.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e12 e22

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c17 : 1
stoichiometry:c5 : 1

m12*m22*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.

Go back
155.0, 119.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e24 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m24*m29*0.1

nodelay

--

true

0

false

PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.

Go back
579.0, 119.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m31*m42*0.1

nodelay

--

true

0

false

PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.

Go back
578.0, 166.0
27.0, 27.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 e32

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m42*m32*0.1

nodelay

--

true

0

false

PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.

Go back
266.0, 466.0
27.0, 27.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 e28

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m45*m28*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
268.0, 520.0
24.0, 24.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e46

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m47*m46*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
294.0, 662.0
27.0, 27.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c47 : 1
stoichiometry:c44 : 1

m49*m48*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
351.0, 667.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e48

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c48 : 1
stoichiometry:c46 : 1

m64*m48*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
503.0, 663.0
25.0, 25.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m28*m66*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
615.0, 659.0
25.0, 25.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 e67

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m68*m67*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
711.0, 419.0
25.0, 25.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 e18

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c61 : 1
stoichiometry:c56 : 1

m70*m18*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
587.0, 322.0
24.0, 24.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e15

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m21*m15*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.

Go back
711.0, 459.0
25.0, 25.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 e19

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c62 : 1
stoichiometry:c58 : 1

m70*m19*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
711.0, 499.0
25.0, 25.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 e20

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c63 : 1
stoichiometry:c60 : 1

m70*m20*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
743.0, 567.0
25.0, 25.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72 e71

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1

m72*m71*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
463.0, 723.0
25.0, 25.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e73

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1

m64*m73*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
315.0, 763.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 e65

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m63*m65*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
422.0, 818.0
27.0, 27.0

p25

p25

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).

Go back
500.0, 876.0
24.0, 24.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).

Go back
267.0, 423.0
25.0, 25.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c82 : 1
stoichiometry:c78 : 1

m45*m44*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
269.0, 385.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 e43

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m45*m43*0.1

nodelay

--

true

0

false

PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.

Go back
674.0, 810.0
27.0, 27.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e69

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).

Go back
474.0, 369.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e13 e22

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c16 : 1
stoichiometry:c9 : 1

m13*m22*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.

Go back
540.0, 876.0
23.0, 23.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).

Go back
576.0, 876.0
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e75

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c89 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).

Go back
619.0, 875.0
25.0, 25.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c90 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).

Go back
420.0, 552.0
24.0, 24.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e14 e23

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c18 : 1
stoichiometry:c13 : 1

m14*m23*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.

Go back
595.0, 419.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e16

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m21*m16*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.

Go back
578.0, 550.0
27.0, 27.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e17

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m21*m17*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.

Go back
211.0, 230.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m25*m24*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR3 when activated by dsRNA mediates MyD88-independent signaling via the TRIF adaptor protein.

Go back
210.0, 337.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m26*m27*0.1

nodelay

--

true

0

false

PMID: 17395579 TLR3 when activated by dsRNA mediates MyD88-independent signaling via the TRIF adaptor protein.

Go back
152.0, 168.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e24 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m24*m30*0.1

nodelay

--

true

0

false

PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.

Go back
612.9571543086322, 352.2790621242674

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 432.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.531325116055, 441.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.5894663844041, 538.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 564.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.0, 564.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.7493109283524, 568.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
103.0, 382.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
103.0, 249.1659319782477

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
115.0, 564.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 242.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 432.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
101.0, 186.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
234.0, 249.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
241.94594513699568, 303.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 311.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.0, 350.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
101.0, 144.07841912241386

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
101.0, 180.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.49063342055234, 138.80898753270714

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
180.0, 132.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
182.41391414578723, 187.00564086991375

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.2743439143629, 444.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
175.0, 180.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 132.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.8599434057004, 143.1159660434202

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 132.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.836821605132, 169.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 180.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 188.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 444.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.0, 480.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
286.33570198232854, 371.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
440.0, 240.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 532.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 544.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 490.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
266.0, 676.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.6564023547028, 685.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.0, 680.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.0, 691.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
286.0, 621.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
294.0, 616.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
319.0, 371.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
432.0, 246.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 676.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 688.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0, 672.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0, 682.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.0, 689.6568542494924

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.0, 432.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.0, 444.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.5538553641524, 442.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 480.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.5876987549067, 449.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0, 295.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 512.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 338.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
554.0, 473.30550946634884

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.0, 531.9999753446532

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 580.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 592.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.104456000465, 529.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 691.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.0, 736.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.9516781055529, 628.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
564.0, 334.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.0, 727.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.381351790664, 743.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.0, 788.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 832.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.0, 832.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 850.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.0, 900.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 436.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0592796928046, 447.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
238.0, 411.629976047529

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.0, 382.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.3812733975551, 410.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.01241221291485, 104.26257158110167

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
283.1854842905948, 195.73270856697349

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
688.0, 738.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 824.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 843.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.2821533250223, 838.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0, 838.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.9711254108329, 899.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.0, 899.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.0, 391.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.1171199266936, 900.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back