1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17405910.csml convertedTime:2009.07.01.11:03

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Targeting bacterial endotoxin: two sides of a coin.
Authors Bosshart H, Heinzelmann M.
Affiliation Department of Surgery, Innate Immunity Research Laboratory, Zurich UniversityHospital, Sternwartstrasse 14, 8091 Zurich, Switzerland. herbert.bosshart@usz.ch
Abstract The term sepsis describes a potentially lethal clinical condition that developsas a result of a dysregulated host response to bacterial infection. The mostcommon bacterial component implicated in initiating the septic syndrome is acell wall molecule derived from Gram-negative bacteria, known aslipopolysaccharide (LPS) or endotoxin. Like all mammals, humans are equippedwith an LPS-sensing machinery consisting, primarily, of LPS-binding protein(LBP), CD14, a glycosylphosphatidylinositol (GPI)-anchored monocytedifferentiation antigen, and toll-like receptor 4 (TLR4), a signal-transducingintegral membrane protein. Modest stimulation of TLR4 facilitates theelimination of invading microorganisms. Potent TLR4 stimulation, however,produces severe reactions in the host, often leading to multiple organ failureand death. The search for pharmaceuticals that reduce mortality in septicpatients has been a painstaking process. Thus far, only a few compounds havebeen found to significantly reduce mortality rates. Perhaps one of the morepromising therapeutic strategies currently pursued is based on theidentification of synthetic or naturally occurring substances that neutralizeLPS or inhibit LPS-mediated activation of host immune cells, such as monocytesand macrophages. Here, we describe a number of diverse molecular structures witha capacity to either enhance or blunt LPS-induced monocyte activation. Theunderlying molecular mechanisms are discussed.
PMID 17405910
Model Abstract

Entity

e1: e10: e11:LBP e12:LPS:LBP e13:TLR4 e14:CD14 e15:LPS:LBP:CD14:TLR4 e16:MD2 e17:LPS:LBP:CD14:TLR4:MD2 e18:LPS:LBP:CD14:TLR4:MD2:MyD88 e19:MyD88 e2: e20:IRAK1 e21:LPS:LBP:CD14:TLR4:MD2:MyD88:IRAK1 e22:IRAK4 e23:LPS:LBP:TLR4:MD2:MyD88:IRAK1:IRAK4 e24:TRAF6 e25:IRAK1{p} e26:IRAK1{p}:TRAF6 e27:JNK e28:IKK e29:TAK1 e3: e30:TAK1{activated} e31:ASK1 e32:ASK1{activated} e33:MEKK3 e34:MEKK3{activated} e35:p38 e36:JNK{activated} e37:IKK{activated} e38:p38{activated} e39:p65:p50:IkappaB{p} e4: e40:p65:p50:IkappaB{ub} e41:p65:p50 e42:p65:p50IkappaB e43:cJun e44:cJun{p} e45:ATF2 e46:ATF2{p} e47:TRAM e48:IkappaB{degraded} e49:NADPH oxidase 4 e5:LPS e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:LBP:CD14 e60: e61: e62: e63:p65:p50_nucleus e64:NADPH oxidase 4:TLR4 e65:NADPH oxidase 4{activated} e66:PKR{active} e67:TrX:TRAF6 e68:TrX e69:ROS e7: e71:TIRAP e72:TRIAP:TLR4 e73:IFN e74:PKR e75:TRIF e76:TRAM:TRIF:TLR4 e77:IRF3 e78:IRF3{ativated} e79:IRF7 e8: e80:IRF7{activated} e81:CD11b/CD18 e82:LPS:LBP:CD11b/CD18 e83:MSR e84:LPS:LBP:MSR e85:LPS{degraded} e86:NOD-1/NOD-2 e87:LPS:LBP:NOD-1/NOD-2 e88:CAP37 e89:LPS:CAP37 e9: e90:Heparin:ATIII:thrombin e91:Heparin:ATIII:thrombin:LPS:LBP e92:Hn e93:LPS:Hn

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p5 p6 p7 p8 p9
Model Detail
225.8103467940918, 220.31259021727482
859.199084382361, 1434.9730118600517

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
234.0886701480494, 242.24548824724286
832.8270222784918, 1347.5516361410891

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
157.5, 166.125
45.0, 27.75

LBP

--

e11

cso30:c:Protein

cso30:i:CC_Extracellular

--

p35 p39

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
83.5, 66.0
49.0, 60.0

LPS:LBP

--

e12

cso30:c:Complex

cso30:i:CC_Extracellular

--

p1

p2 p33 p34 p36 p38 p39

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
560.5, 218.0
39.0, 60.0

TLR4

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23

p3 p22 p29 p30

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
417.5, 206.125
45.0, 27.75

CD14

--

e14

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
615.5, 184.0
57.56171892128918, 111.40977855733392

LPS:LBP:CD14:TLR4

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
630.125, 25.5
27.75, 45.0

MD2

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
680.5, 178.0
55.50909888182415, 107.43696557772418

LPS:LBP:CD14:TLR4:MD2

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5

true true false false

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
764.5, 183.0
54.666301249725954, 105.80574435430826

LPS:LBP:CD14:TLR4:MD2:MyD88

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5 p7

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
738.125, 321.5
27.75, 45.0

MyD88

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
225.8103467940918, 220.31259021727482
859.199084382361, 1434.9730118600517

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
834.125, 313.5
27.75, 45.0

IRAK1

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
865.375, 188.5
52.74791712343783, 102.09274281955713

LPS:LBP:CD14:TLR4:MD2:MyD88:IRAK1

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
922.125, 293.5
27.75, 45.0

IRAK4

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

p9

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
985.375, 184.5
53.61790177592633, 103.77658408243806

LPS:LBP:TLR4:MD2:MyD88:IRAK1:IRAK4

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p7

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
969.5, 463.125
45.0, 33.75

TRAF6

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26

p8 p25 p40

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
994.125, 381.5
27.75, 45.0

IRAK1{p}

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

p8

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
838.75, 452.5
42.936464088397784, 47.707182320441994

IRAK1{p}:TRAF6

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p11 p12 p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
965.5, 670.125
45.0, 27.75

JNK

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p41 p42

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
962.875, 769.5
32.25, 45.0

IKK

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p14 p43 p44

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
765.5, 470.125
45.0, 27.75

TAK1

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
242.994328481739, 240.0780587001957
824.8311210070666, 1395.442074894211

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
765.5, 614.125
45.0, 27.75

TAK1{activated}

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11

p10 p14 p15

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
909.5, 470.125
45.0, 27.75

ASK1

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12 p40

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
909.5, 614.125
45.0, 27.75

ASK1{activated}

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12 p40

p42 p44 p46

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
881.5, 578.125
45.0, 27.75

MEKK3

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
837.5, 618.125
45.0, 27.75

MEKK3{activated}

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

p13

p41 p43 p45

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
951.5, 885.125
45.0, 27.75

p38

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p45 p46

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
769.5, 670.125
45.0, 27.75

JNK{activated}

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

p15 p41 p42

p16

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
774.875, 769.5
32.25, 45.0

IKK{activated}

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14 p43 p44

p18

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
771.5, 885.125
45.0, 27.75

p38{activated}

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10 p45 p46

p17

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
567.5, 934.125
45.0, 33.75

p65:p50:IkappaB{p}

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
274.78469460388646, 274.6676285453069
761.2503887627721, 1326.2629352039871

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
687.5, 938.125
45.0, 33.75

p65:p50:IkappaB{ub}

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
859.75, 1061.5
40.5, 45.0

p65:p50

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
563.5, 882.125
45.0, 33.75

p65:p50IkappaB

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true false false

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
569.5, 615.125
45.0, 33.75

cJun

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
569.5, 663.125
45.0, 33.75

cJun{p}

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
564.5, 759.125
45.0, 33.75

ATF2

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
568.5, 807.125
45.0, 33.75

ATF2{p}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
249.5, 710.125
45.0, 27.75

TRAM

--

e47

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p30

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
771.5, 941.25
45.0, 43.5

IkappaB{degraded}

--

e48

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
195.5, 301.125
49.68504729321795, 30.6391124974844

NADPH oxidase 4

--

e49

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p22

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
254.0, 123.0
60.0, 34.0

LPS

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1 p37

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
407.6826022977057, 1047.859797342992
467.2487099785956, 487.4006430228833

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
458.14894341271224, 1059.410484013552
273.21432948469106, 472.3883028887082

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
413.77336760468927, 1054.3651447344678
455.0671793646288, 474.38994823993147

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
414.64347693425833, 1055.3659674100793
453.3269607054905, 472.3883028887082

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
407.6826022977057, 1047.859797342992
467.2487099785956, 487.4006430228833

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
407.6826022977057, 1047.859797342992
467.2487099785956, 487.4006430228833

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
414.64347693425833, 1055.3659674100793
453.3269607054905, 472.3883028887082

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
748.7654594887847, 1248.024332465326
29.19113209952217, 30.395486258144967

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
672.1958384867057, 1388.1395070509598
82.66038630906253, 86.07075010260367

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
407.6826022977057, 1047.859797342992
467.2487099785956, 487.4006430228833

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
481.5, 179.0
52.832629840337674, 73.71994861442467

LPS:LBP:CD14

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p2

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
517.8104942121297, 1264.4566156776928
14.797080095160664, 8.194810666190605

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
517.3163778234098, 1240.0177510604326
50.64692984378508, 104.85977957870941

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
538.563382538364, 1308.219233713252
7.905862219517663, 9.093531020375877

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
683.75, 1145.5
40.5, 45.0

p65:p50_nucleus

--

e63

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
233.375, 211.5
37.767868888401665, 73.0991010743258

NADPH oxidase 4:TLR4

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p23

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
245.5, 426.125
45.0, 27.75

NADPH oxidase 4{activated}

--

e65

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

p47

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
561.5, 475.125
45.0, 33.75

PKR{active}

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24

p31

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
957.625, 1133.5
36.75, 45.0

TrX:TRAF6

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
953.5, 1074.125
45.0, 27.75

TrX

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26

p25

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
914.125, 1005.5
27.75, 45.0

ROS

--

e69

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p47

p26

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
237.09896954948852, 226.08703505621065
842.6066194465817, 1373.3148346319701

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
229.5, 486.125
45.0, 27.75

TIRAP

--

e71

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p29

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
247.375, 544.5
32.64991229993423, 63.193378645033974

TRIAP:TLR4

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p24

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
485.5, 1200.0
45.0, 24.0

IFN

--

e73

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
417.5, 479.125
45.0, 33.75

PKR

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
249.5, 754.125
45.0, 27.75

TRIF

--

e75

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p30

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
244.375, 629.5
32.024610830958125, 61.983117737338304

TRAM:TRIF:TLR4

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p32 p27

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
470.125, 569.5
27.75, 45.0

IRF3

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31 p27

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
470.125, 641.5
27.75, 45.0

IRF3{ativated}

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31 p27

p28

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
426.125, 685.5
27.75, 45.0

IRF7

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
240.10926895092769, 250.32471484275897
808.3225703420957, 1350.0026878544343

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
426.125, 749.5
27.75, 45.0

IRF7{activated}

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
239.5, 814.0
49.0, 60.0

CD11b/CD18

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p33

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
218.5, 890.0
74.5247458756874, 91.25479086818864

LPS:LBP:CD11b/CD18

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p33

--

true true false false

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
248.0, 994.0
24.0, 60.0

MSR

--

e83

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p34

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
248.0, 1074.0
24.0, 60.0

LPS:LBP:MSR

--

e84

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p34

p35

true true false false

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
348.0, 957.0
48.196438828259616, 46.58989086731762

LPS{degraded}

--

e85

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
315.5, 1170.0
49.0, 60.0

NOD-1/NOD-2

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p36

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
309.5, 1255.0
60.929511748041996, 74.60756540576571

LPS:LBP:NOD-1/NOD-2

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

--

true true false false

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
351.0, 188.5
42.239999999999995, 31.679999999999993

CAP37

--

e88

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p37

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
291.0, 226.5
58.4, 43.8

LPS:CAP37

--

e89

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p37

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
248.136734021432, 274.56239462930733
804.6321344157533, 1332.297740883289

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
166.5, 26.0
43.0, 60.0

Heparin:ATIII:thrombin

--

e90

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p38

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
358.5, 38.0
43.0, 60.0

Heparin:ATIII:thrombin:LPS:LBP

--

e91

cso30:c:Complex

cso30:i:CC_Extracellular

--

p38

--

true true false false

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
50.0, 431.0
60.0, 34.0

Hn

--

e92

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
78.0, 567.0
60.0, 34.0

LPS:Hn

--

e93

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p39

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
197.0, 113.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c6 : 1

m5*m11*0.1

nodelay

--

true

0

false

PMID: 17405910 association of single LPS molecules with plasmaderived LPS-binding protein (LBP)

Go back
841.0, 885.0
30.0, 30.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 e30

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c49 : 1
stoichiometry:c42 : 1

m35*m30*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
773.0, 533.0
30.0, 30.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e29 e26

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c34 : 1
stoichiometry:c32 : 1

m29*m26*0.1

nodelay

--

true

0

false

PMID: 17405910 TRAF6, a RING domain-containing E3 ubiquitin ligase, activates mitogen-activated protein kinase kinase kinases (MAP3K), transforming growth factor beta (TGF-beta)-activating kinase 1 (TAK1), mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase (MEKK3, and apoptosis signal-regulating kinase 1 (ASK1).

Go back
917.0, 529.0
30.0, 30.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e26

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m31*m26*0.1

nodelay

--

true

0

false

PMID: 17405910 TRAF6, a RING domain-containing E3 ubiquitin ligase, activates mitogen-activated protein kinase kinase kinases (MAP3K), transforming growth factor beta (TGF-beta)-activating kinase 1 (TAK1), mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase (MEKK3, and apoptosis signal-regulating kinase 1 (ASK1).

Go back
845.0, 533.0
30.0, 30.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 e26

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m33*m26*0.1

nodelay

--

true

0

false

PMID: 17405910 TRAF6, a RING domain-containing E3 ubiquitin ligase, activates mitogen-activated protein kinase kinase kinases (MAP3K), transforming growth factor beta (TGF-beta)-activating kinase 1 (TAK1), mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase (MEKK3, and apoptosis signal-regulating kinase 1 (ASK1).

Go back
829.0, 777.0
30.0, 30.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 e28

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c30 : 1
stoichiometry:c40 : 1

m30*m28*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
841.0, 669.0
30.0, 30.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 e30

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c43 : 1
stoichiometry:c29 : 1

m27*m30*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
665.0, 665.0
30.0, 30.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 e36

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c58 : 1
stoichiometry:c53 : 1

m43*m36*0.1

nodelay

--

true

0

false

PMID: 17405910 Subsequent activation of cJun N-terminal kinase (Jnk), I-kappaB kinase (IKK) complex (consisting of alpha, beta and gamma subunits), and p38, leads to phosphorylation of cJun, I-kappaB, and ATF2, respectively.

Go back
664.0, 781.0
30.0, 30.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e45 e38

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c139 : 1
stoichiometry:c55 : 1

m45*m38*0.1

nodelay

--

true

0

false

PMID: 17405910 Subsequent activation of cJun N-terminal kinase (Jnk), I-kappaB kinase (IKK) complex (consisting of alpha, beta and gamma subunits), and p38, leads to phosphorylation of cJun, I-kappaB, and ATF2, respectively.

Go back
659.0, 884.0
30.0, 30.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e42 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c62 : 1
stoichiometry:c57 : 1

m42*m37*0.1

nodelay

--

true

0

false

PMID: 17405910 Subsequent activation of cJun N-terminal kinase (Jnk), I-kappaB kinase (IKK) complex (consisting of alpha, beta and gamma subunits), and p38, leads to phosphorylation of cJun, I-kappaB, and ATF2, respectively.

Go back
639.0, 964.0
30.0, 30.0

p19

p19

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 17405910 Phosphorylated I-kappaB is ubiquitinated and degraded by the 26S proteosome, leaving the p65-p50 dimer (NF-kappaB), which is now free to translocate to the nucleus.

Go back
425.0, 97.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e14

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m12*m14*0.1

nodelay

--

true

0

false

PMID: 17405910 one LPS bound to one LBP, the so formed protein?glycolipid complex is recognized, with high specificity, by CD14

Go back
731.0, 992.0
30.0, 30.0

p20

p20

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e40

e48 e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17405910 Phosphorylated I-kappaB is ubiquitinated and degraded by the 26S proteosome, leaving the p65-p50 dimer (NF-kappaB), which is now free to translocate to the nucleus.

Go back
805.0, 1065.0
30.0, 30.0

p21

p21

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e41

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17405910 Phosphorylated I-kappaB is ubiquitinated and degraded by the 26S proteosome, leaving the p65-p50 dimer (NF-kappaB), which is now free to translocate to the nucleus.

Go back
281.0, 289.0
30.0, 30.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 e13

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m49*m13*0.1

nodelay

--

true

0

false

PMID: 17405910, 15356101 The generation of ROS appears to result from a direct activation of membrane-bound NADPH oxidase 4 by TLR4.

Go back
249.0, 369.0
30.0, 30.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e64

e65 e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17405910, 15356101 The generation of ROS appears to result from a direct activation of membrane-bound NADPH oxidase 4 by TLR4.

Go back
493.0, 485.0
30.0, 30.0

p29

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 e72

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c141 : 1
stoichiometry:c76 : 1

m74*m72*0.1

nodelay

--

true

0

false

PMID: 17405910, 12062447, 12062447 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).

Go back
1165.0, 705.0
30.0, 30.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 e68

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m24*m68*0.1

nodelay

--

true

0

false

PMID: 17405910, 9564042 ASK1 can only be activated by TRAF6 if the associated thioredoxin (TrX) is displaced from TRAF6.

Go back
1093.0, 705.0
37.0, 37.0

p26

p26

cso30:i:ME_Dissociation

cso30:i:CC_Extracellular

--

e67 e69

e24 e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c83 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m67*m69*0.1

nodelay

--

true

0

false

PMID: 17405910, 15864310 This dissociation depends on the formation of ROS.

Go back
369.0, 613.0
30.0, 30.0

p31

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e77 e76

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c143 : 1
stoichiometry:c101 : 1

m77*m76*0.1

nodelay

--

true

0

false

PMID: 17405910, 12062447, 15029200, 16006187 TIR domain-containing adapter inducing interferon (TRIF) and TRIF-related adapter molecule (TRAM), both involved in the activation of IRF3 and IRF7.

Go back
493.0, 1129.0
30.0, 30.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c88 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 17405910, 12062447, 12062447 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).

Go back
349.0, 397.0
30.0, 30.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m13*m71*0.1

nodelay

--

true

0

false

PMID: 17405910, 12062447, 12062447 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).

Go back
565.0, 89.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e13

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6*m13*0.1

nodelay

--

true

0

false

PMID: 17405910, 11034352 activation of TLR4, which is thought to initiate intracellular signaling upon association with a CD14 molecule that is occupied by an LPS?LBP complex.

Go back
365.0, 481.0
30.0, 30.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 e75 e13

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m47*m75*m13*0.1

nodelay

--

true

0

false

PMID: 17405910 Apart from MyD88 and TIRAP, additional TLR4 adapter proteins have been identified.

Go back
369.0, 573.0
30.0, 30.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e77 e66

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c142 : 1
stoichiometry:c98 : 1

m77*m66*0.1

nodelay

--

true

0

false

PMID: 17405910, 12062447, 15029200, 16006187 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).

Go back
377.0, 709.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e79 e76

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c105 : 1
stoichiometry:c100 : 1

m79*m76*0.1

nodelay

--

true

0

false

PMID: 17405910, 16006187 TIR domain-containing adapter inducing interferon (TRIF) and TRIF-related adapter molecule (TRAM), both involved in the activation of IRF3 and IRF7.

Go back
165.0, 437.0
30.0, 30.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c106 : 1

m12*m81*0.1

nodelay

--

true

0

false

PMID: 17405910, 9820516 macrophages express several other LPS receptors, for example, CD11b/CD18

Go back
157.0, 645.0
30.0, 30.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m12*m83*0.1

nodelay

--

true

0

false

PMID: 17405910, 1852209 macrophages express several other LPS receptors, for example, CD11b/CD18, class A macrophage scavenger receptor (MSR)

Go back
309.0, 1025.0
30.0, 30.0

p35

p35

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e84

e85 e83 e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 17405910, 1852209 MSR acts as a scavenger for LPS, that is, rather than eliciting a proinflammatory response, the MSR?LPS complex is internalized and LPS is partially degraded.

Go back
157.0, 989.0
30.0, 30.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m12*m86*0.1

nodelay

--

true

0

false

PMID: 17405910, 16021602 NOD-1 and -2 agonists also act in synergy with LPS to stimulate cytokine production.

Go back
337.0, 125.0
30.0, 30.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 e88

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m5*m88*0.1

nodelay

--

true

0

false

PMID: 17405910, 15275964 Cationic proteins, e.g., protamines and CAP37, associate with LPS and bind to cellular surfaces.

Go back
253.0, 53.0
30.0, 30.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e90 e12

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m90*m12*0.1

nodelay

--

true

0

false

PMID: 17405910 Heparin exerts its anticoagulant effect through binding to AT III and thrombin. Apart from its interaction with proteins of the coagulation pathway, heparin binds to LBP and displaces LPS

Go back
65.0, 297.0
30.0, 30.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e92

e93 e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c66 : 1

m12*m92*0.1

nodelay

--

true

0

false

PMID: 17405910, 14550561 LPS is bound and neutralized by poly-L-histidine.

Go back
629.0, 93.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m15*m16*0.1

nodelay

--

true

0

false

PMID: 17405910 TLR4 signaling depends on the presence of MD2, a secretory glycoprotein that associates with TLR4.

Go back
957.0, 529.0
30.0, 30.0

p12

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e24

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m31*m24*0.1

nodelay

--

true

0

false

PMID: 17405910, 9564042 ASK1 can only be activated by TRAF6 if the associated thioredoxin (TrX) is displaced from TRAF6.

Go back
869.0, 693.0
30.0, 30.0

p15

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 e27

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c84 : 1
stoichiometry:c128 : 1

m34*m27*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
897.0, 721.0
30.0, 30.0

p15

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e27

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m32*m27*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
869.0, 801.0
30.0, 30.0

p15

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 e28

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m34*m28*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
889.0, 829.0
30.0, 30.0

p15

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e28

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m32*m28*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
873.0, 913.0
30.0, 30.0

p15

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 e35

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m34*m35*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
897.0, 941.0
30.0, 30.0

p15

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e35

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m32*m35*0.1

nodelay

--

true

0

false

PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).

Go back
600.0, 1012.0
32.0, 32.0

p24

p47

cso30:i:ME_UnknownProduction

cso30:i:CC_Nucleoplasm

--

e65

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c140 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17405910, 15356101 The generation of ROS appears to result from a direct activation of membrane-bound NADPH oxidase 4 by TLR4.

Go back
737.0, 97.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e19 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m19*m17*0.1

nodelay

--

true

0

false

PMID: 17405910 Subsequent to the association of MyD88 with TLR4, MyD88 recruits the IL-1 receptor-associated kinase 1 (IRAK1).

Go back
833.0, 97.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m18*m20*0.1

nodelay

--

true

0

false

PMID: 17405910 Subsequent to the association of MyD88 with TLR4, MyD88 recruits the IL-1 receptor-associated kinase 1 (IRAK1).

Go back
937.0, 369.0
30.0, 30.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23

e25 e22 e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c124 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 17405910 Phosphorylation of IRAK1 by IRAK4 and other kinases results in the dissociation of IRAK1 from TLR4.

Go back
917.0, 413.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m25*m24*0.1

nodelay

--

true

0

false

PMID: 17405910 Phosphorylated IRAK1 associates, in the cytosol, with tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6).

Go back
925.0, 97.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m21*m22*0.1

nodelay

--

true

0

false

PMID: 17405910 Phosphorylation of IRAK1 by IRAK4 and other kinases results in the dissociation of IRAK1 from TLR4.

Go back
234.91362769883096, 132.1723892887157

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 131.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.0, 739.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.0, 633.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.0, 126.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
184.69008049810384, 474.81943910456044

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 668.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
182.0, 467.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
111.0, 126.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
177.87712426483117, 682.7766576685863

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
175.0, 675.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 71.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 1060.6568542494924

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 1010.2179589656599

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
110.0, 126.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
190.22272827167723, 1025.0599595213355

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
181.0, 1019.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
314.0, 140.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.25733059193243, 162.67492401257016

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.33774828479216, 155.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
210.0, 59.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
133.0, 72.37904265401798

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 123.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
283.0, 68.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
83.0208260313957, 126.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
80.0, 335.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
82.0, 327.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.8765178896406, 266.4283088980578

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.0, 498.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.4190369351473, 559.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.3861999450876, 497.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.7439751853265, 692.0076972702698

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.6064078549882, 698.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.0, 135.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.3577934305443, 697.1405215862079

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.7611400011626, 796.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.7462185896749, 797.9990241521741

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.5398594650478, 803.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.2584848522703, 802.3636881022716

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
910.6048436519278, 907.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.6550446131422, 908.3238528289896

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.9278956114879, 913.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.1910112359551, 913.5056179775281

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.9637651601156, 814.332307672574

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
728.0, 134.4966569186612

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 1028.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 507.367808234867

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
406.2163243858115, 503.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
276.0, 633.9990241521741

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
757.0, 127.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.0, 134.30510305950008

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.0, 135.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 127.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
961.0183750985082, 288.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0, 149.8335884449155

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.0, 389.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
942.8178369248513, 346.79072967793434

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
954.6212736897495, 408.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.0057081353821, 446.2850231591362

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.5978308147678, 438.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.0, 134.50052974727944

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 134.99770617535876

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.0, 127.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0, 684.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.0, 684.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
133.0, 97.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
867.0, 792.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 498.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 563.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0, 498.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.6568542494924, 497.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
932.0, 559.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.0, 496.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
880.6568542494924, 568.6568542494924

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 563.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 500.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
440.0, 135.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 792.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.9993904065218, 899.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.9930645847388, 899.3330443576974

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.0, 642.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
864.0, 646.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.3959705878862, 642.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 642.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
862.0, 646.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
907.0183849426446, 642.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
791.0, 642.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 127.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.0, 646.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
913.4807350181795, 642.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
615.0, 644.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 680.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 781.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.6193931775946, 801.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0, 899.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.7674048207653, 908.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.9971570716941, 681.2132575219118

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 961.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
140.63583982428023, 105.38619994508757

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.0, 967.104456000465

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 518.2335992557728

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
694.9257522779262, 807.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
278.0, 518.4404159196479

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.030160137081, 272.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.7265016217189, 511.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
91.0, 200.37764020735798

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.974522228289, 1081.6379617782632

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.3526358860416, 1091.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
245.0, 307.31519189844283

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0, 125.75855260443383

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.850626237539, 252.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0447410007557, 279.2089120009301

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 259.1764748343923

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
265.0, 399.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
255.0, 285.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
463.0, 497.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.0, 495.81623092398854

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1005.0, 497.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 741.9961766609647

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.3800988890138, 735.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 127.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.0, 749.6330628435802

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1003.5501085413067, 504.16915122904663

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
983.7990899339961, 742.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
942.0, 748.8530624600262

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
906.7812018488698, 689.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.7733408252956, 1028.89081263318

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
183.31981088289433, 201.89038017039698

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 454.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0, 1159.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.37469310325696, 263.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.0, 119.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.0, 428.9390534401322

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.16485939411723, 427.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
485.0, 687.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
406.5121497996618, 597.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.0, 972.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.0, 988.3813823519705

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.0, 1016.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.9928681081361, 589.3377268214706

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.0, 599.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
414.50674493453687, 712.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back