1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17456803.csml convertedTime:2009.07.01.11:03

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title G-protein-coupled receptor expression, function, and signaling in macrophages.
Authors Lattin J, Zidar DA, Schroder K, Kellie S, Hume DA, Sweet MJ.
Affiliation Cooperative Research Centre for Chronic Inflammatory Diseases, University ofQueensland, St. Lucia, Brisbane, QLD 4072, Australia.
Abstract G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. Asmacrophages are key cellular mediators of acute and chronic inflammation, wereview here the role of GPCRs in regulating macrophage function, with a focus oncontribution to disease pathology and potential therapeutic applications. Withinthis analysis, we highlight novel GPCRs with a macrophage-restricted expressionprofile, which provide avenues for further exploration. We also review anemerging literature, which documents novel roles for GPCR signaling componentsin GPCR-independent signaling in macrophages. In particular, we examine thecrosstalk between GPCR and TLR signaling pathways and highlight GPCR signalingmolecules which are likely to have uncharacterized functions in this celllineage.
PMID 17456803
Model Abstract

Entity

G010262:IL-6 G010389:IL-1beta G010514:iNOS G010815:MCP1 G011075:TACR1 G012063:Cr2 G030823:CR1 MO000000011:ERK MO000000022:p38{active} MO000000023:JNK MO000000048:AKT MO000000058:NF-kappaB MO000000099:GM-CSF MO000000204:TNF MO000000214:IL-1 MO000000276:AP-1 MO000000314:Class A GPCR MO000004670:ERK1 MO000004676:ERK2 MO000007384:IL-6 MO000013119:STAT1 MO000013122:STAT3 MO000013668:PAR1 precursor MO000016589:IL-1alpha MO000016597:IL-1beta MO000016882:LPS MO000016894:MAPK MO000017008:thrombin MO000017020:PAR2 precursor MO000017023:trkA MO000017069:GRK MO000017072:beta-arrestin MO000017073:beta-arrestin1 MO000017074:beta-arrestin2 MO000017075:tubulin MO000017093:GRK2 MO000017111:GRK5 MO000017157:CXCR4 MO000017247:IL-10 MO000017264:IL-8 MO000017265:IL-12 MO000017271:IP-10 MO000017280:MCP-1 MO000017281:CCR5 MO000017394:PAR2{active} MO000017818:JNK3 MO000018417:PAR1{active} MO000019937:CCR4 MO000021432:NADPH oxidase MO000021803:MMP2 MO000021957:MMP9 MO000022274:C5aR MO000033549:FPRL2 MO000033607:C5a MO000063316:FPRL1 MO000064001:CD97 MO000069674:RGS19 e1: e10: e100:LTB4:LTB4R2 e101:NADPH oxidase{active} e102:IL-12 e103:IL-10 e104:IP-10 e105:CCL22 e106:CCL22 e107:CCR4:CCL22 e108:EMR2 e109:EMR1 e11:GDP: alpha Gprotein e110:Chondroitin sulfate e111:CD97:Chondroitin sulfate e112:EMR2:Chondroitin sulfate e113:proteoglycan e114:EMR1:Proteoglycan e115:PTx e116:Galpha i2 e117:Galpha i2{p} e118:TNF e119:p38 e12:Beta-gamma: GDP:alpha Gprotein e120:ERK1{active} e121:ERK2{active} e122:AP-1{active} e123:Galpha i1 e124:Galpha i3 e125:Thromnaxane B2 protein e126:Thrombaxane B2 e127:NF-kappaB{active} e128:C3a:C3aR e129:Ligand:CXCR2 e13:Class A GPCR: Chemokine e130:Ligand:FPR e131:IL-8:IL-8R e132:GBeta2L1 e133:IFN-alpha:receptor e134:IFN-alpha:receptor:STAT1 e135:IFN-beta:receptor e136:IFN-beta:receptor:STAT1 e137:IGF:IGFR-1 e138:IGF-IGFR1:STAT3 e139:RGS7 e14:Class A GPCR:Chemokine:Beta-gamma:GDP:alpha G protein e140:GIPC e141:RGS19:GIPC e142:IGFR1 e143:IGFR1:RGS19:GIPC e144:MAPK{active} e145:RGS19:GIPC:TrkA e146:GRK2 e147:GRK5 e148: e149: e15:Class A GPCR:Chemokine:Beta-gamma:GTP:alpha G protein e150: e151: e152: e153: e154: e155: e156: e157: e158: e159: e16:Chemokine:Class A GPCR:Beta-gamma G protein e160: e161:GRK6 e162:IFN e163:tubulin{p} e164:Synucleins e165:Synucleins{p} e166:Phosducin e167:Phosducin{p} e168:PI3K e169:GRK:PI3K e17:GTP:alpha G protein e170:GAP e171:GRK:GAP e172:Galphaq e173:Galphaq:GRK e174:Beta Gamma G protein:GRK e175:GRK:ERK e176:GRK:AKT e177:GRK2:G beta Gamma e178:GRK3 e179:GRK3:Beta Gamma G protein e18:Chemokine:Class A GPCR{p}:Beta-gamma G protein e180:Galphaq:GRK3 e181:Galphaq:GRK2 e182:p105 e183:GRK5:p105 e184:GRK5:p105{p} e185:SRC e186:RAF-1 e187:Beta arrestin2:RAF-1:SRC e188:Ligand:CXCR4 e189:ERK{active} e19:second messenger dependent protein kinase e190:Ligand:PAR-2 e191:Ligand:Beta 2 adrenergic receptor e192:Ligand:Angiotensin II type IA e193:beta-arrestin:ERK e194:ERK e195:beta arrestin:ERK{p} e196:beta-arrestin e197:JNK3{active} e198:CSF-1 e199:CSF-1{active} e2: e20:beta-arrestin1 e200:JNK3:beta arrestin2 e201:ASK1 e202:JNK3:beta arrestin 2: ASK1 e203:beta-arrestin:NF-kappaB e204:IKappaB-alpha e205:beta arrestin1:IKappaB-alpha e206:beta arrestin2:IkkapB-alpha e207:NF-kappaB{active} e208:DNA e209:NF-KappaB{active}:DNA e21:beta-arrestin2 e210:TRAF6 e211:TRAF6{ub} e212:TRAF6{ub} oligomer e213:JNK{active} e214:IKK{active} e215:IKK e216:LPS:TLR4 e217:IL-1:IL-1R e218:beta arrestin1:TRAF6 e219:beta arrestin2:TRAF6 e22:Class B GPCR e23:Class B GPCR: Chemokine e24:Class B GPCR:Chemokine:Beta-gamma:GDP:alpha G protein e25:Class B GPCR:Chemokine:Beta-gamma:GTP:alpha G protein e26:Chemokine:Class B GPCR:Beta-gamma G protein e27:Chemokine:Class B GPCR{p}:Beta-gamma G protein e28:Chemokine: Calss A GPCR{p}:Beta-gamma G protein:Beta arrestin2 e29:Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin1 e3: e30:Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin2 e31:Chemokine: Calss A GPCR{p}:Beta-gamma G protein:Beta arrestin1 e32:Chemokine:Class A GPCR{p}:Beta-gamma G protein e33:Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin2 e34:Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin1 e35:C5a:C5aR e36:CD88 e37:C5a:CD88 e38:Superoxide anion e39:PGE2 e4: e40:IL-1 e41:TNF e42:FPR1 e43:N-formylated methionine e44:FPR1: N-formylated methionine e45:fMLP e46:FPR1: fMLP e47:FPRL1:fMLP e48:endogenous ligand e49:FPRL2: endogenous ligand e5:Beta Gamma Grotein e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Chemokine e60: e61: e62: e63:Nonformylated bacterial protein e64:FPR1: Nonformylated bacterial protein e65:FPRL1: Nonformylated bacterial protein e66:annexin 1 e67:FPR1:aneexin1 e68:FPLR1:annexin 1 e69:Serum amyloid A e7: e70:Serum amyloid A: FPR1 e71:Serum amyloid A: FPRL1 e72:amyloid beta peptide e73:amyloid beta peptide: FPR1 e74:amyloid beta peptide: FPRL1 e75:NO e76:CCR5{p} e77:CXCR4{p} e78:PARs e79:PARs{active} e8: e80:IL-1alpha e81:PAR2 receptor activating peptides e82:IL-8 e83:NK-1R e84:SP e85:NK-1R:SP e86:ROS e87:PGD2 e88:SP e89:ET-1:receptor e9: e90:cox-2 e91:GM-CSF e92:ET-1:ETAR e93:ET-2:receptor e94:MMp2 e95:MMp9 e96:superoxide e97:02- e98:PAF:PAFR e99:LTB4:LTB4R1

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p130 p131 p132 p133 p134 p135 p136 p137 p138 p139 p14 p140 p141 p142 p143 p144 p145 p146 p147 p148 p149 p15 p150 p151 p152 p153 p154 p155 p156 p157 p158 p159 p16 p160 p161 p162 p163 p164 p165 p166 p167 p168 p169 p17 p170 p171 p172 p173 p174 p175 p176 p177 p178 p179 p18 p180 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
762.0, 950.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p55 p57 p58 p63 p68 p77

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
754.0, 1010.0
28.0, 28.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p53 p62 p78

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
702.0, 966.0
27.5, 27.5

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45 p87

p46 p92 p93

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
740.0, 1160.0
24.0, 24.0

MCP1

--

G010815

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p59 p60

true true true true

csml-variable:Double

m93710

10

false

infinite

0

unit false false false
TRANSFACG010815

--

Go back
584.0, 1224.0
24.0, 24.0

TACR1

--

G011075

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p71

true true true true

csml-variable:Double

m93961

10

false

infinite

0

unit false false false
TRANSFACG011075

--

Go back
606.0, 938.0
27.0, 27.0

Cr2

--

G012063

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m94868

10

false

infinite

0

unit false false false
TRANSFACG012063

--

Go back
531.0, 963.0
26.0, 26.0

CR1

--

G030823

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m109518

10

false

infinite

0

unit false false false
TRANSFACG030823

--

Go back
1041.0, 613.0
30.0, 30.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

p159

p144 p153 p154 p155 p156

true true true true

csml-variable:Double

m179

10

false

infinite

0

unit false false false

--

Go back
398.0, 522.0
20.0, 20.0

p38{active}

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

p106

--

true true true true

csml-variable:Double

m120

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
701.0, 1741.0
22.0, 22.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p174

true true true true

csml-variable:Double

m217

10

false

infinite

0

unit false false false

--

Go back
940.0, 620.0
24.0, 24.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p145

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false

--

Go back
287.0, 459.0
26.0, 26.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p119 p120 p121 p122 p123 p166 p168 p170

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1464.0, 1328.0
23.0, 23.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

p79

--

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
58.0, 942.0
27.5, 27.5

TNF

--

MO000000204

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p66 p75 p80 p90 p91 p110 p111 p112

p128 p168 p170

true true true true

csml-variable:Double

m175

10

false

infinite

0

unit false false false
TRANSPATHMO000000204

--

Go back
24.0, 972.0
39.5, 39.5

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31 p67 p102

--

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
689.0, 445.0
22.0, 22.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p109

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
350.0, 158.0
28.0, 28.0

Class A GPCR

--

MO000000314

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m249

10

false

infinite

0

unit false false false
TRANSPATHMO000000314

--

Go back
352.0, 560.0
24.0, 24.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p107 p162

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
506.0, 386.0
28.0, 28.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p108 p163

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
1520.0, 808.0
24.0, 24.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55 p57 p58 p63 p68 p77

p136

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
816.0, 416.0
24.0, 24.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p124 p125

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
583.0, 275.0
26.0, 26.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p126

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
136.0, 1136.0
24.0, 24.0

PAR1 precursor

--

MO000013668

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m1420

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000013668

--

Go back
1511.0, 1075.0
26.0, 26.0

IL-1alpha

--

MO000016589

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

--

true true true true

csml-variable:Double

m1584

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016589

--

Go back
1509.0, 997.0
22.0, 22.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53 p62 p78

p135 p136

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
508.0, 2080.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71 p72 p87 p102 p103 p104 p105 p106 p107 p108 p109 p127 p133 p134 p135 p136

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1082.0, 1534.0
20.0, 20.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p131

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
4.0, 1204.0
24.0, 24.0

thrombin

--

MO000017008

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p56

true true true true

csml-variable:Double

m1909

10

false

infinite

0

unit false false false
InterProIPR009003
TRANSPATHMO000017008

--

Go back
135.0, 1227.0
26.0, 26.0

PAR2 precursor

--

MO000017020

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p61

true true true true

csml-variable:Double

m1920

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017020

--

Go back
1353.0, 1849.0
21.0, 21.0

trkA

--

MO000017023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p132

true true true true

csml-variable:Double

m1922

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017023

--

Go back
668.0, 248.0
24.0, 24.0

GRK

--

MO000017069

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p14 p137 p138 p139 p140 p141 p142 p143 p144 p145

true true true true

csml-variable:Double

m1961

10

false

infinite

0

unit false false false
TRANSPATHMO000017069

--

Go back
718.0, 1038.0
20.0, 20.0

beta-arrestin

--

MO000017072

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p157

true true true true

csml-variable:Double

m1964

10

false

infinite

0

unit false false false
TRANSPATHMO000017072

--

Go back
853.0, 317.0
22.0, 22.0

beta-arrestin1

--

MO000017073

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p8 p167 p168 p177 p178

true true true true

csml-variable:Double

m1965

10

false

infinite

0

unit false false false
InterProIPR000698
TRANSPATHMO000017073

--

Go back
915.0, 391.0
18.0, 18.0

beta-arrestin2

--

MO000017074

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p9 p152 p160 p164 p169 p170 p171 p179 p180

true true true true

csml-variable:Double

m1966

10

false

infinite

0

unit false false false
InterProIPR000698
TRANSPATHMO000017074

--

Go back
539.0, 79.0
18.0, 18.0

tubulin

--

MO000017075

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p137

true true true true

csml-variable:Double

m1967

10

false

infinite

0

unit false false false
TRANSPATHMO000017075

--

Go back
845.0, 1477.0
21.5, 21.5

GRK2

--

MO000017093

cso30:c:Protein

cso30:i:CC_CellComponent

--

p136

p146 p149

true true true true

csml-variable:Double

m1984

10

false

infinite

0

unit false false false

--

Go back
605.0, 1465.0
22.0, 22.0

GRK5

--

MO000017111

cso30:c:Protein

cso30:i:CC_CellComponent

--

p135

p150

true true true true

csml-variable:Double

m1999

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017111

--

Go back
1357.0, 1613.0
22.0, 22.0

CXCR4

--

MO000017157

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p50

true true true true

csml-variable:Double

m2033

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017157

--

Go back
24.0, 804.0
24.0, 24.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p95 p113 p114 p115

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1457.0, 1185.0
22.0, 22.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64 p76

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
28.0, 840.0
24.0, 24.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p94

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
38.0, 882.0
20.0, 20.0

IP-10

--

MO000017271

cso30:c:Protein

cso30:i:CC_CellComponent

--

p96

--

true true true true

csml-variable:Double

m2127

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017271

--

Go back
1478.0, 1254.0
28.5, 28.5

MCP-1

--

MO000017280

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59 p60

--

true true true true

csml-variable:Double

m2133

10

false

infinite

0

unit false false false
InterProIPR008097
TRANSPATHMO000017280

--

Go back
1351.0, 1495.0
26.0, 26.0

CCR5

--

MO000017281

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p48

true true true true

csml-variable:Double

m2134

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017281

--

Go back
140.0, 1284.0
24.0, 24.0

PAR2{active}

--

MO000017394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56 p61

p58 p60 p62 p63 p64

true true true true

csml-variable:Double

m2226

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017394

--

Go back
818.0, 1658.0
20.0, 20.0

JNK3

--

MO000017818

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p160 p164

true true true true

csml-variable:Double

m2570

10

false

infinite

0

unit false false false

--

Go back
137.0, 1181.0
21.0, 21.0

PAR1{active}

--

MO000018417

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p57 p59

true true true true

csml-variable:Double

m3055

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000018417

--

Go back
141.0, 669.0
22.0, 22.0

CCR4

--

MO000019937

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p98

true true true true

csml-variable:Double

m4465

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000019937

--

Go back
323.0, 1259.0
25.0, 25.0

NADPH oxidase

--

MO000021432

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88 p89

true true true true

csml-variable:Double

m5783

10

false

infinite

0

unit false false false
TRANSPATHMO000021432

--

Go back
537.0, 1465.0
21.5, 21.5

MMP2

--

MO000021803

cso30:c:Protein

cso30:i:CC_CellComponent

--

p81 p82

--

true true true true

csml-variable:Double

m6138

10

false

infinite

0

unit false false false
InterProIPR006026
TRANSPATHMO000021803

--

Go back
681.0, 1485.0
22.0, 22.0

MMP9

--

MO000021957

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83 p84

--

true true true true

csml-variable:Double

m6281

10

false

infinite

0

unit false false false
InterProIPR006026
TRANSPATHMO000021957

--

Go back
132.0, 748.0
24.0, 24.0

C5aR

--

MO000022274

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m6571

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000022274

--

Go back
1356.0, 1000.0
23.0, 23.0

FPRL2

--

MO000033549

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m12225

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000033549

--

Go back
50.0, 758.0
20.0, 20.0

C5a

--

MO000033607

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26

true true true true

csml-variable:Double

m12280

10

false

infinite

0

unit false false false
InterProIPR002890
TRANSPATHMO000033607

--

Go back
1354.0, 906.0
19.0, 19.0

FPRL1

--

MO000063316

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p38 p40 p42 p44

true true true true

csml-variable:Double

m38196

10

false

infinite

0

unit false false false
TRANSPATHMO000063316

--

Go back
733.0, 1969.0
22.0, 22.0

CD97

--

MO000064001

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p99

true true true true

csml-variable:Double

m38875

10

false

infinite

0

unit false false false
TRANSPATHMO000064001

--

Go back
901.0, 1481.0
22.0, 22.0

RGS19

--

MO000069674

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p129

true true true true

csml-variable:Double

m44517

10

false

infinite

0

unit false false false
TRANSPATHMO000069674

--

Go back
106.0133938905281, 134.1674713491035
1308.4866215473467, 1899.9225744867492

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
120.76971366292321, 195.85481841018566
1262.6970856208156, 1776.259748531503

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
138.5, 1650.0
18.64349923262442, 36.08419206314404

LTB4:LTB4R2

--

e100

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p89 p91 p93

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
231.0, 1043.0
25.0, 25.0

NADPH oxidase{active}

--

e101

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88 p89

--

true true true true

csml-variable:Double

m102

10

false

infinite

0

unit false false false
TRANSPATHMO000021432

--

Go back
483.0, 921.0
41.366782006920396, 22.062283737024217

IL-12

--

e102

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p94

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
587.0, 889.0
42.560553633218, 22.698961937716263

IL-10

--

e103

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p95 p113 p114 p115

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
575.0, 1003.0
50.60553633217993, 26.98961937716263

IP-10

--

e104

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p96

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
628.0, 867.0
48.944636678200695, 26.103806228373703

CCL22

--

e105

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p97

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
61.0, 711.0
14.544434050514498, 33.56407857811038

CCL22

--

e106

cso30:c:Protein

cso30:i:CC_Cytosol

--

p97

p98

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
134.5, 697.0
19.68340276255207, 38.09690857268143

CCR4:CCL22

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p98

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
967.5, 1985.0
24.469244288224957, 37.64499121265378

EMR2

--

e108

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p100

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1063.5, 1961.0
24.469244288224957, 37.64499121265378

EMR1

--

e109

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p101

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
420.0, 317.5
39.2, 29.400000000000002

GDP: alpha Gprotein

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
834.0, 1991.5
28.532904004829938, 17.59529080297846

Chondroitin sulfate

--

e110

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p99 p100

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
905.5, 1976.0
20.342688007016, 39.37294452970839

CD97:Chondroitin sulfate

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

p99

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
1021.5, 1964.0
20.342688007016, 39.37294452970839

EMR2:Chondroitin sulfate

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

p100

--

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
1196.0, 2057.0
40.49621530698066, 22.947855340622368

proteoglycan

--

e113

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p101

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1138.5, 1969.0
19.527077395308048, 37.79434334575751

EMR1:Proteoglycan

--

e114

cso30:c:Complex

cso30:i:CC_Cytosol

--

p101

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
20.0, 1039.0
31.61480235492009, 17.915054667788056

PTx

--

e115

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p102 p104 p105 p106 p107 p108 p109

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
512.0, 292.5
24.93459448581204, 15.376333266250757

Galpha i2

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p103 p111 p114 p118

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
614.0, 365.0
27.5609756097561, 22.048780487804876

Galpha i2{p}

--

e117

cso30:c:Protein

cso30:i:CC_Cytosol

--

p103

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
290.0, 786.0
27.5, 27.5

TNF

--

e118

cso30:c:Protein

cso30:i:CC_CellComponent

--

p105

--

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
TRANSPATHMO000000204

--

Go back
510.0, 482.0
20.0, 20.0

p38

--

e119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p106

true true true true

csml-variable:Double

m121

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
427.5, 208.0
25.851358106982175, 31.654724212631233

Beta-gamma: GDP:alpha Gprotein

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3 p11

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
304.0, 612.0
24.0, 24.0

ERK1{active}

--

e120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p107 p162

--

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
602.0, 446.0
28.0, 28.0

ERK2{active}

--

e121

cso30:c:Protein

cso30:i:CC_CellComponent

--

p108 p163

--

true true true true

csml-variable:Double

m123

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
689.0, 533.0
22.0, 22.0

AP-1{active}

--

e122

cso30:c:Protein

cso30:i:CC_CellComponent

--

p109

--

true true true true

csml-variable:Double

m124

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
748.0, 400.5
24.93459448581204, 15.376333266250757

Galpha i1

--

e123

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p112 p113 p117

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
416.0, 432.5
24.93459448581204, 15.376333266250757

Galpha i3

--

e124

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p110 p115 p116

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
719.5, 598.0
16.820889514992956, 27.277118132421005

Thromnaxane B2 protein

--

e125

cso30:c:Protein

cso30:i:CC_Cytosol

--

p116 p117

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
642.0, 984.0
44.01384083044983, 23.474048442906575

Thrombaxane B2

--

e126

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p116 p117 p118

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
447.0, 391.0
26.0, 26.0

NF-kappaB{active}

--

e127

cso30:c:Protein

cso30:i:CC_CellComponent

--

p119 p120 p121 p122 p123 p168 p170

--

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
129.5, 283.0
21.817583863187895, 42.227581670686256

C3a:C3aR

--

e128

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p120

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
134.5, 226.0
18.14733611050208, 35.12387634290726

Ligand:CXCR2

--

e129

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p121

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
484.5, 151.0
22.041876781407588, 42.661696996272745

Class A GPCR: Chemokine

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1353.5, 523.0
21.287436965577722, 41.20149090111818

Ligand:FPR

--

e130

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p122

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
258.5, 153.0
19.49989037491778, 37.74172330629248

IL-8:IL-8R

--

e131

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p123

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
770.0, 363.5
27.83256188367881, 17.16341316160193

GBeta2L1

--

e132

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p124 p125 p126

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
1347.5, 179.0
17.85507564130673, 34.55821091865819

IFN-alpha:receptor

--

e133

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p124

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
1344.5, 248.0
22.75867131583777, 31.75628555698293

IFN-alpha:receptor:STAT1

--

e134

cso30:c:Complex

cso30:i:CC_Extracellular

--

p124

--

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
1351.5, 295.0
17.85507564130673, 34.55821091865819

IFN-beta:receptor

--

e135

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p125

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
1348.5, 348.0
22.75867131583777, 31.75628555698293

IFN-beta:receptor:STAT1

--

e136

cso30:c:Complex

cso30:i:CC_Extracellular

--

p125

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
434.5, 162.0
18.249287436965574, 35.32120149090111

IGF:IGFR-1

--

e137

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p126

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
552.5, 164.0
22.892824371444302, 31.94347586713158

IGF-IGFR1:STAT3

--

e138

cso30:c:Complex

cso30:i:CC_Extracellular

--

p126

--

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
379.0, 1083.0
49.82698961937716, 26.574394463667822

RGS7

--

e139

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p127 p128

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
600.5, 140.0
22.79023674068638, 31.80033033584145

Class A GPCR:Chemokine:Beta-gamma:GDP:alpha G protein

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
969.0, 1370.5
29.897363654658875, 18.43670758703965

GIPC

--

e140

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p129

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
969.5, 1459.0
21.801366438926845, 26.69555074154308

RGS19:GIPC

--

e141

cso30:c:Complex

cso30:i:CC_Cytosol

--

p129

p130 p132

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
1356.5, 1714.0
23.50966608084359, 36.168717047451665

IGFR1

--

e142

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p130

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
1357.5, 1779.0
21.987502740627058, 42.55645691734268

IGFR1:RGS19:GIPC

--

e143

cso30:c:Complex

cso30:i:CC_Cytosol

--

p130

p131

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
926.0, 1538.0
20.0, 20.0

MAPK{active}

--

e144

cso30:c:Protein

cso30:i:CC_CellComponent

--

p131

--

true true true true

csml-variable:Double

m147

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
1364.5, 1892.0
23.287392182051757, 32.494035602862915

RGS19:GIPC:TrkA

--

e145

cso30:c:Complex

cso30:i:CC_Cytosol

--

p132

--

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
656.0, 1053.0
40.79584775086506, 21.757785467128027

GRK2

--

e146

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p133

p136

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
668.0, 1277.0
40.79584775086506, 21.757785467128027

GRK5

--

e147

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p135

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
355.72010213187974, 837.4900779962736
535.2648954173125, 485.42645077882946

--

e148

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false true false

--

Go back
363.69425327403746, 844.9658446920466
519.316593132998, 470.4749173872848

--

e149

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false true false

--

Go back
736.5, 176.0
22.79023674068638, 31.80033033584145

Class A GPCR:Chemokine:Beta-gamma:GTP:alpha G protein

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
362.63833924868106, 846.0217587174028
519.316593132998, 470.4749173872848

--

e150

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false true false

--

Go back
355.72010213187974, 837.4900779962736
535.2648954173125, 485.42645077882946

--

e151

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false true false

--

Go back
658.7378455338605, 1176.3915015379598
94.69304481311856, 85.72212477819168

--

e152

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false true false

--

Go back
355.72010213187974, 837.4900779962736
535.2648954173125, 485.42645077882946

--

e153

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false true false

--

Go back
355.72010213187974, 837.4900779962736
535.2648954173125, 485.42645077882946

--

e154

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false true false

--

Go back
413.5326979125207, 848.993979180674
312.98543232967637, 470.4749173872848

--

e155

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false true false

--

Go back
746.4535080975894, 1036.8438565502054
33.440409650525226, 30.272370841528133

--

e156

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m159

0

false

infinite

0

unit false true false

--

Go back
481.3129826208581, 1028.8697054080496
58.019472343291135, 104.43505021792413

--

e157

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m160

0

false

infinite

0

unit false true false

--

Go back
481.8790262534754, 1053.2095816106003
16.95105274871833, 8.161617990123649

--

e158

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false true false

--

Go back
505.6528588234099, 1096.7949413221465
9.056698121879588, 9.056698121879599

--

e159

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false true false

--

Go back
856.5, 162.0
22.397433761039828, 27.425429095150815

Chemokine:Class A GPCR:Beta-gamma G protein

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6 p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
362.69748438126754, 843.9690757992773
521.3101309185371, 472.46845517282367

--

e160

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m163

0

false

infinite

0

unit false true false

--

Go back
596.0, 1049.0
40.79584775086506, 21.757785467128027

GRK6

--

e161

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p134

--

true true true true

csml-variable:Double

m164

0

false

infinite

0

unit false false false

--

Go back
1453.0, 1404.0
13.547240411599628, 31.26286248830683

IFN

--

e162

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p136

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false false false

--

Go back
555.0, 39.0
18.0, 18.0

tubulin{p}

--

e163

cso30:c:Protein

cso30:i:CC_CellComponent

--

p137

--

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000017075

--

Go back
656.5, 24.0
14.430670154960755, 23.40108673777419

Synucleins

--

e164

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p138

true true true true

csml-variable:Double

m167

0

false

infinite

0

unit false false false

--

Go back
744.5, 28.0
14.430670154960755, 23.40108673777419

Synucleins{p}

--

e165

cso30:c:Protein

cso30:i:CC_Extracellular

--

p138

--

true true true true

csml-variable:Double

m168

0

false

infinite

0

unit false false false

--

Go back
845.0, 23.0
14.34985968194574, 33.11506080449016

Phosducin

--

e166

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p139

true true true true

csml-variable:Double

m169

0

false

infinite

0

unit false false false

--

Go back
937.0, 67.0
14.34985968194574, 33.11506080449016

Phosducin{p}

--

e167

cso30:c:Protein

cso30:i:CC_Extracellular

--

p139

--

true true true true

csml-variable:Double

m170

0

false

infinite

0

unit false false false

--

Go back
763.0, 534.5
25.759999999999994, 19.32

PI3K

--

e168

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p140

true true true true

csml-variable:Double

m171

0

false

infinite

0

unit false false false

--

Go back
884.5, 526.0
23.026162306282284, 28.195300783202807

GRK:PI3K

--

e169

cso30:c:Complex

cso30:i:CC_Cytosol

--

p140

--

true true true true

csml-variable:Double

m172

0

false

infinite

0

unit false false false

--

Go back
729.0, 314.5
37.12, 27.84

GTP:alpha G protein

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5 p13

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
760.0, 579.0
15.055191768007482, 34.742750233863426

GAP

--

e170

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p141

true true true true

csml-variable:Double

m173

0

false

infinite

0

unit false false false

--

Go back
865.5, 611.0
21.131811364772535, 25.87568738543576

GRK:GAP

--

e171

cso30:c:Complex

cso30:i:CC_Cytosol

--

p141

--

true true true true

csml-variable:Double

m174

0

false

infinite

0

unit false false false

--

Go back
985.0, 534.5
29.728315556449985, 18.332461259810827

Galphaq

--

e172

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p142 p148 p149

true true true true

csml-variable:Double

m176

0

false

infinite

0

unit false false false

--

Go back
964.5, 570.0
22.266788868521918, 27.26545575737377

Galphaq:GRK

--

e173

cso30:c:Complex

cso30:i:CC_Cytosol

--

p142

--

true true true true

csml-variable:Double

m177

0

false

infinite

0

unit false false false

--

Go back
335.5, 429.0
24.602066322279615, 30.124979170138307

Beta Gamma G protein:GRK

--

e174

cso30:c:Complex

cso30:i:CC_Cytosol

--

p143

--

true true true true

csml-variable:Double

m178

0

false

infinite

0

unit false false false

--

Go back
1102.5, 545.0
18.510748208631902, 22.666222296283955

GRK:ERK

--

e175

cso30:c:Complex

cso30:i:CC_Cytosol

--

p144

--

true true true true

csml-variable:Double

m180

0

false

infinite

0

unit false false false

--

Go back
799.5, 641.0
24.283619396767204, 29.735044159306778

GRK:AKT

--

e176

cso30:c:Complex

cso30:i:CC_Cytosol

--

p145

--

true true true true

csml-variable:Double

m182

0

false

infinite

0

unit false false false

--

Go back
988.5, 730.0
23.017997000499918, 28.185302449591735

GRK2:G beta Gamma

--

e177

cso30:c:Complex

cso30:i:CC_Cytosol

--

p146

--

true true true true

csml-variable:Double

m183

0

false

infinite

0

unit false false false

--

Go back
891.0, 810.5
25.279999999999998, 18.96

GRK3

--

e178

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p147 p148

true true true true

csml-variable:Double

m184

0

false

infinite

0

unit false false false

--

Go back
816.5, 686.0
22.511748041993005, 27.56540576570572

GRK3:Beta Gamma G protein

--

e179

cso30:c:Complex

cso30:i:CC_Cytosol

--

p147

--

true true true true

csml-variable:Double

m186

0

false

infinite

0

unit false false false

--

Go back
960.5, 138.0
22.397433761039828, 27.425429095150815

Chemokine:Class A GPCR{p}:Beta-gamma G protein

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6 p7 p20 p21

p16 p19 p22

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
932.5, 678.0
22.903682719546744, 28.045325779036833

Galphaq:GRK3

--

e180

cso30:c:Complex

cso30:i:CC_Cytosol

--

p148

--

true true true true

csml-variable:Double

m187

0

false

infinite

0

unit false false false

--

Go back
1141.3028661889687, 659.0
21.197133811031495, 25.95567405432428

Galphaq:GRK2

--

e181

cso30:c:Complex

cso30:i:CC_Cytosol

--

p149

--

true true true true

csml-variable:Double

m188

0

false

infinite

0

unit false false false

--

Go back
575.0, 1624.5
25.58663715033206, 15.778426242704771

p105

--

e182

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p150

true true true true

csml-variable:Double

m189

0

false

infinite

0

unit false false false

--

Go back
764.5, 1626.0
22.53624395934011, 27.595400766538912

GRK5:p105

--

e183

cso30:c:Complex

cso30:i:CC_Cytosol

--

p150

p151

true true true true

csml-variable:Double

m190

0

false

infinite

0

unit false false false

--

Go back
816.5, 1498.0
22.53624395934011, 27.595400766538912

GRK5:p105{p}

--

e184

cso30:c:Complex

cso30:i:CC_Cytosol

--

p151

p107 p108

true true true true

csml-variable:Double

m191

0

false

infinite

0

unit false false false

--

Go back
1113.0, 427.5
29.052123163614407, 17.91547595089556

SRC

--

e185

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p152

true true true true

csml-variable:Double

m192

0

false

infinite

0

unit false false false

--

Go back
978.0, 481.5
28.000000000000007, 21.0

RAF-1

--

e186

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p152

true true true true

csml-variable:Double

m193

0

false

infinite

0

unit false false false

--

Go back
1238.5, 525.0
26.546522297669302, 37.04165902000368

Beta arrestin2:RAF-1:SRC

--

e187

cso30:c:Complex

cso30:i:CC_Extracellular

--

p152

p153 p154 p155 p156

true true true true

csml-variable:Double

m194

0

false

infinite

0

unit false false false

--

Go back
1355.5, 392.0
16.346196009647006, 31.637798728349043

Ligand:CXCR4

--

e188

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p153

true true true true

csml-variable:Double

m195

0

false

infinite

0

unit false false false

--

Go back
1157.0, 609.0
30.0, 30.0

ERK{active}

--

e189

cso30:c:Protein

cso30:i:CC_CellComponent

--

p153 p154 p155 p156

--

true true true true

csml-variable:Double

m196

10

false

infinite

0

unit false false false

--

Go back
925.0, 296.0
13.802619270346115, 31.85219831618334

second messenger dependent protein kinase

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p15

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
1354.5, 434.0
18.85419864064898, 36.49199736899803

Ligand:PAR-2

--

e190

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p154

true true true true

csml-variable:Double

m197

0

false

infinite

0

unit false false false

--

Go back
1354.5, 577.0
19.751370313527733, 38.228458671344

Ligand:Beta 2 adrenergic receptor

--

e191

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p155

true true true true

csml-variable:Double

m198

0

false

infinite

0

unit false false false

--

Go back
1354.5, 737.0
19.54067090550318, 37.820653365490024

Ligand:Angiotensin II type IA

--

e192

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p156

true true true true

csml-variable:Double

m199

0

false

infinite

0

unit false false false

--

Go back
788.5, 1130.0
22.960839860023327, 28.115314114314277

beta-arrestin:ERK

--

e193

cso30:c:Complex

cso30:i:CC_Cytosol

--

p157

p158

true true true true

csml-variable:Double

m200

0

false

infinite

0

unit false false false

--

Go back
733.0, 905.0
30.0, 30.0

ERK

--

e194

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p157

true true true true

csml-variable:Double

m201

10

false

infinite

0

unit false false false

--

Go back
858.5, 1084.0
19.13947675387435, 23.436093984335944

beta arrestin:ERK{p}

--

e195

cso30:c:Complex

cso30:i:CC_Extracellular

--

p158

p159

true true true true

csml-variable:Double

m202

0

false

infinite

0

unit false false false

--

Go back
1194.0, 762.0
20.0, 20.0

beta-arrestin

--

e196

cso30:c:Protein

cso30:i:CC_CellComponent

--

p159

p166

true true true true

csml-variable:Double

m203

10

false

infinite

0

unit false false false
TRANSPATHMO000017072

--

Go back
886.0, 1722.0
20.0, 20.0

JNK3{active}

--

e197

cso30:c:Protein

cso30:i:CC_CellComponent

--

p160

--

true true true true

csml-variable:Double

m204

10

false

infinite

0

unit false false false

--

Go back
145.5, 1768.0
20.485419864064898, 39.64919973689982

CSF-1

--

e198

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p161

true true true true

csml-variable:Double

m205

0

false

infinite

0

unit false false false

--

Go back
141.5, 1716.0
20.485419864064898, 39.64919973689982

CSF-1{active}

--

e199

cso30:c:Complex

cso30:i:CC_Cytosol

--

p161

p162 p163

true true true true

csml-variable:Double

m206

0

false

infinite

0

unit false false false

--

Go back
106.0133938905281, 134.1674713491035
1308.4866215473467, 1899.9225744867492

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1062.0, 150.0
19.0, 19.0

beta-arrestin1

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p17 p19

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR000698
TRANSPATHMO000017073

--

Go back
1016.5, 1686.0
22.74854190968172, 27.8553574404266

JNK3:beta arrestin2

--

e200

cso30:c:Complex

cso30:i:CC_Cytosol

--

p164

p165

true true true true

csml-variable:Double

m207

0

false

infinite

0

unit false false false

--

Go back
1064.5, 1824.0
15.11571744817871, 24.5119742402898

ASK1

--

e201

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p165

true true true true

csml-variable:Double

m208

0

false

infinite

0

unit false false false

--

Go back
939.5, 1835.0
24.715727656450728, 34.48706184621031

JNK3:beta arrestin 2: ASK1

--

e202

cso30:c:Complex

cso30:i:CC_Cytosol

--

p165

--

true true true true

csml-variable:Double

m209

0

false

infinite

0

unit false false false

--

Go back
1166.5, 356.0
18.959840026662224, 23.216130644892516

beta-arrestin:NF-kappaB

--

e203

cso30:c:Complex

cso30:i:CC_Cytosol

--

p166

--

true true true true

csml-variable:Double

m210

0

false

infinite

0

unit false false false

--

Go back
1036.0, 803.5
23.200000000000003, 17.40000000000001

IKappaB-alpha

--

e204

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p167 p169

true true true true

csml-variable:Double

m211

0

false

infinite

0

unit false false false

--

Go back
1144.5, 677.0
23.924345942342946, 29.295117480419933

beta arrestin1:IKappaB-alpha

--

e205

cso30:c:Complex

cso30:i:CC_Cytosol

--

p167

--

true true true true

csml-variable:Double

m212

0

false

infinite

0

unit false false false

--

Go back
1126.5, 904.0
19.75187468755207, 24.185969005165806

beta arrestin2:IkkapB-alpha

--

e206

cso30:c:Complex

cso30:i:CC_Cytosol

--

p169

--

true true true true

csml-variable:Double

m213

0

false

infinite

0

unit false false false

--

Go back
447.0, 1191.0
26.0, 26.0

NF-kappaB{active}

--

e207

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p171

true true true true

csml-variable:Double

m214

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
538.0, 1269.5
60.0, 13.0

DNA

--

e208

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p171

true true true true

csml-variable:Double

m215

0

false

infinite

0

unit false false false

--

Go back
454.0, 1255.5
60.0, 17.0

NF-KappaB{active}:DNA

--

e209

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p171

--

true true true true

csml-variable:Double

m216

0

false

infinite

0

unit false false false

--

Go back
1151.0, 147.0
18.0, 18.0

beta-arrestin2

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p16 p18

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR000698
TRANSPATHMO000017074

--

Go back
245.0, 1846.5
29.607566914872205, 18.25799959750453

TRAF6

--

e210

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p172 p175 p177 p178 p179 p180

true true true true

csml-variable:Double

m218

0

false

infinite

0

unit false false false

--

Go back
405.0, 1885.0
29.2442267319804, 22.42057382785164

TRAF6{ub}

--

e211

cso30:c:Protein

cso30:i:CC_Cytosol

--

p172 p175

p173

true true true true

csml-variable:Double

m220

0

false

infinite

0

unit false false false

--

Go back
348.5, 1746.0
23.148641893017835, 28.345275787368777

TRAF6{ub} oligomer

--

e212

cso30:c:Complex

cso30:i:CC_Cytosol

--

p173

p174 p176

true true true true

csml-variable:Double

m221

0

false

infinite

0

unit false false false

--

Go back
757.0, 1701.0
22.0, 22.0

JNK{active}

--

e213

cso30:c:Protein

cso30:i:CC_CellComponent

--

p174

--

true true true true

csml-variable:Double

m222

10

false

infinite

0

unit false false false

--

Go back
780.0, 1825.0
16.210477081384468, 37.40879326473339

IKK{active}

--

e214

cso30:c:Protein

cso30:i:CC_Cytosol

--

p176

--

true true true true

csml-variable:Double

m223

0

false

infinite

0

unit false false false

--

Go back
736.0, 1869.0
16.210477081384468, 37.40879326473339

IKK

--

e215

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p176

true true true true

csml-variable:Double

m224

0

false

infinite

0

unit false false false

--

Go back
379.5, 1963.0
17.95023021267266, 34.74238105678579

LPS:TLR4

--

e216

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p172 p178 p180

true true true true

csml-variable:Double

m225

0

false

infinite

0

unit false false false

--

Go back
145.5, 1572.0
21.1311115983337, 40.89892567419426

IL-1:IL-1R

--

e217

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p175 p177 p179

true true true true

csml-variable:Double

m226

0

false

infinite

0

unit false false false

--

Go back
304.5, 1678.0
22.66688885185802, 27.75537410431594

beta arrestin1:TRAF6

--

e218

cso30:c:Complex

cso30:i:CC_Cytosol

--

p177 p178

p172

true true true true

csml-variable:Double

m227

0

false

infinite

0

unit false false false

--

Go back
886.5, 1779.0
27.90084985835694, 34.1643059490085

beta arrestin2:TRAF6

--

e219

cso30:c:Complex

cso30:i:CC_Cytosol

--

p179 p180

p172

true true true true

csml-variable:Double

m228

0

false

infinite

0

unit false false false

--

Go back
190.0, 154.0
28.0, 28.0

Class B GPCR

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000314

--

Go back
140.5, 171.0
22.041876781407588, 42.661696996272745

Class B GPCR: Chemokine

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
140.5, 336.0
22.79023674068638, 31.80033033584145

Class B GPCR:Chemokine:Beta-gamma:GDP:alpha G protein

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
140.5, 384.0
22.79023674068638, 31.80033033584145

Class B GPCR:Chemokine:Beta-gamma:GTP:alpha G protein

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
136.5, 438.0
22.397433761039828, 27.425429095150815

Chemokine:Class B GPCR:Beta-gamma G protein

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14 p15

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
140.5, 490.0
22.397433761039828, 27.425429095150815

Chemokine:Class B GPCR{p}:Beta-gamma G protein

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14 p15

p17 p18

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1200.5, 168.0
22.261515874472387, 31.062580289961467

Chemokine: Calss A GPCR{p}:Beta-gamma G protein:Beta arrestin2

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p20

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
136.5, 536.0
22.261515874472387, 31.062580289961467

Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin1

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p24

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
132.18312632147484, 160.3372037800503
1256.1471566854536, 1847.583109624856

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
144.5, 584.0
22.261515874472387, 31.062580289961467

Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin2

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p23

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1268.5, 192.0
22.261515874472387, 31.062580289961467

Chemokine: Calss A GPCR{p}:Beta-gamma G protein:Beta arrestin1

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p21

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1056.5, 442.0
22.397433761039828, 27.425429095150815

Chemokine:Class A GPCR{p}:Beta-gamma G protein

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
232.5, 656.0
22.261515874472387, 31.062580289961467

Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin2

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
200.5, 624.0
22.261515874472387, 31.062580289961467

Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
141.5, 804.0
20.60776145582109, 39.88598991449244

C5a:C5aR

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p27 p28 p29 p30 p31 p119

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
138.5, 860.0
26.182776801405975, 40.28119507908611

CD88

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
136.5, 915.0
22.01468976101732, 42.60907695680772

C5a:CD88

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
393.0, 763.0
45.54247266610597, 25.80740117746005

Superoxide anion

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
354.0, 676.0
43.95290159798149, 24.90664423885618

PGE2

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p30 p73

p94 p95 p96 p97

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
180.59713131872752, 206.13423553420745
1159.3191466909507, 1755.9890461165398

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
442.0, 1066.0
52.21453287197233, 27.847750865051903

IL-1

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p31 p67 p102

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
490.0, 990.0
52.21453287197233, 27.847750865051903

TNF

--

e41

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p32 p66 p75 p80 p90 p91 p105 p110 p111 p112

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1351.5, 624.0
25.634446397188047, 39.43760984182777

FPR1

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33 p34 p37 p39 p41 p43

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1505.0, 458.5
30.766753874018917, 18.972831555644998

N-formylated methionine

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1352.5, 679.0
22.211795658846743, 42.990572242929176

FPR1: N-formylated methionine

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1528.0, 732.5
23.796133567662565, 15.46748681898067

fMLP

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34 p35

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1353.5, 784.0
20.342688007016005, 39.37294452970839

FPR1: fMLP

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p45 p48 p49 p53 p54 p55

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1353.5, 947.0
21.858364393773293, 42.306511729883795

FPRL1:fMLP

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p47 p50

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1060.0, 692.5
24.25307557117751, 15.764499121265377

endogenous ligand

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1358.5, 1049.0
19.751370313527733, 38.228458671344

FPRL2: endogenous ligand

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
350.0, 263.5
27.446166230629906, 16.925135842221778

Beta Gamma Grotein

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1 p143 p146 p147

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
342.72010213187974, 835.4900779962736
557.2665090018677, 505.3794969905213

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
402.90903606504247, 847.4668373687246
325.85043543126, 489.81339338711757

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
349.98428381346844, 842.2353895577498
542.7381456386904, 491.88887386757085

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
351.0220240536957, 843.2731297979761
540.662665158237, 489.81339338711757

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
342.72010213187974, 835.4900779962736
557.2665090018677, 505.3794969905213

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
342.72010213187974, 835.4900779962736
557.2665090018677, 505.3794969905213

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
349.9227075699241, 844.3724462817474
540.662665158237, 489.81339338711757

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
749.5142763008403, 1043.0381260416593
34.81494957933276, 31.516691198132865

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
658.1931351608714, 1188.3217596734326
98.58532282155944, 89.24566065951711

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
342.72010213187974, 835.4900779962736
557.2665090018677, 505.3794969905213

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
282.0, 75.5
27.03562084926544, 16.671966190380356

Chemokine

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2 p10

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
474.06468278079643, 1060.076550473697
17.647811522965885, 8.497094436983586

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
473.4753724004745, 1034.7362041198453
60.404313983021055, 108.72776516943802

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
498.81571875432763, 1105.4534497585043
9.428966085154501, 9.428966085154519

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1531.0, 596.5
25.828134433487616, 15.927349567317366

Nonformylated bacterial protein

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37 p38

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1352.5, 475.0
22.007893005919755, 42.595921946941466

FPR1: Nonformylated bacterial protein

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1352.5, 841.0
23.645910984433236, 45.766279324709494

FPRL1: Nonformylated bacterial protein

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1010.0, 972.5
20.8, 15.600000000000007

annexin 1

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39 p40

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1352.5, 1099.0
22.041876781407584, 42.66169699627274

FPR1:aneexin1

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1353.5, 1164.0
20.628151721113788, 39.92545494409121

FPLR1:annexin 1

--

e68

cso30:c:Complex

cso30:i:CC_NuclearEnvelopeLumen

--

p40

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
953.0, 1190.5
29.876977152899826, 19.42003514938489

Serum amyloid A

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41 p42

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
191.40054114380592, 132.61399028631467
914.1489374456556, 1295.3254316573143

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1348.5, 1298.0
23.081780311335233, 44.67441350581012

Serum amyloid A: FPR1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1358.5, 1230.0
18.18811664108748, 35.20280640210479

Serum amyloid A: FPRL1

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
919.0, 1275.5
25.30755711775044, 16.44991212653779

amyloid beta peptide

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p43 p44

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1358.5, 1361.0
19.771760578820434, 38.26792370094278

amyloid beta peptide: FPR1

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1354.5, 1421.0
19.771760578820434, 38.26792370094278

amyloid beta peptide: FPRL1

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
916.0, 895.0
15.043030869971938, 34.714686623012156

NO

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

p46 p92 p93 p104

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1359.0, 1559.0
26.0, 26.0

CCR5{p}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47 p48

--

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017281

--

Go back
1361.0, 1665.0
22.0, 22.0

CXCR4{p}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p50

--

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017157

--

Go back
132.5, 1014.0
23.989455184534265, 36.90685413005273

PARs

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p51

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
132.5, 1090.0
23.989455184534265, 36.90685413005273

PARs{active}

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
117.15595514500639, 132.47523247212132
1029.1527238145397, 1494.3297549787112

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
762.0, 1076.0
44.27335640138409, 23.612456747404845

IL-1alpha

--

e80

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p54

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
40.5, 1339.0
15.607164419400283, 25.30891527470315

PAR2 receptor activating peptides

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p61

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
702.0, 1088.0
44.169550173010386, 23.557093425605537

IL-8

--

e82

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p64 p76

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
140.5, 1346.0
23.646748681898067, 36.37961335676626

NK-1R

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

p71

p65

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
39.0, 1460.5
25.260615818072054, 15.577379754477763

SP

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

p72

p65

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
141.5, 1416.0
21.117518088138564, 40.87261565446174

NK-1R:SP

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p66 p67 p68 p69 p70

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
339.0, 1450.0
49.85702270815811, 28.252312867956263

ROS

--

e86

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p69

p136

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
349.0, 1402.5
29.66794123566109, 18.295230428657675

PGD2

--

e87

cso30:c:Protein

cso30:i:CC_Cytosol

--

p70

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
512.0, 1163.0
48.73702422145329, 25.99307958477509

SP

--

e88

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p72

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
561.5, 1967.0
21.97390923043192, 42.530146897610166

ET-1:receptor

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p73 p74 p75 p76 p77 p78 p79 p81 p83 p85 p86

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
183.37547752684745, 135.33647465792797
872.9501925749153, 1256.6376644203303

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
604.0, 1159.0
47.07612456747405, 25.10726643598616

cox-2

--

e90

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p74

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
675.0, 1215.0
50.19031141868512, 26.768166089965398

GM-CSF

--

e91

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p79

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
261.5, 1963.0
21.97390923043192, 42.530146897610166

ET-1:ETAR

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p80

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
622.5, 1989.0
19.996053497040123, 38.70203902652927

ET-2:receptor

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p82 p84

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
544.0, 1083.0
48.73702422145329, 25.993079584775085

MMp2

--

e94

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p81 p82

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
668.0, 1115.0
48.73702422145329, 25.993079584775085

MMp9

--

e95

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p83 p84

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
233.0, 1535.0
45.99663582842725, 26.06476030277544

superoxide

--

e96

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
344.0, 1501.0
39.058031959629936, 22.13288477712363

02-

--

e97

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p86

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
682.5, 1970.0
19.003727252795436, 36.781407586055685

PAF:PAFR

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p87

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
142.5, 1498.0
18.64349923262442, 36.08419206314404

LTB4:LTB4R1

--

e99

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p88 p90 p92

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
430.0, 262.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m11*0.1

nodelay

--

true

0

false

PMID: 17456803 In the absence of agonist, the Beta{gamma}-subunit associates with the GDP-bound {alpha}-subunit.

Go back
210.0, 74.0
19.0, 19.0

p2

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 e6

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m22*m6*0.1

nodelay

--

true

0

false

PMID: 17456803 Figure 1

Go back
926.0, 1910.0
19.0, 19.0

p99

p100

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e110 e108

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1

m111*m109*0.1

nodelay

--

true

0

false

PMID: 17456803,12829604 In humans, EMR2 and CD97 were identified as receptors for cell surface chondroitin sulfate , suggesting that the ligand for EMR1 may be a proteoglycan.

Go back
1114.0, 1886.0
19.0, 19.0

p99

p101

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e109 e113

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c281 : 1
stoichiometry:c282 : 1

m110*m114*0.1

nodelay

--

true

0

false

PMID: 17456803,12829604 In humans, EMR2 and CD97 were identified as receptors for cell surface chondroitin sulfate , suggesting that the ligand for EMR1 may be a proteoglycan.

Go back
270.0, 854.0
19.0, 19.0

p102

p102

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 MO000016882 e115

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c285 : 1
stoichiometry:c286 : 1
stoichiometry:c284 : 1

m40*m155666*0.1

nodelay

--

true

0

false

PMID: 17456803,3095921 Jakway and DeFranco first showed that pretreatment of the macrophage cell line P388D1 with PTx reduced the production of IL-1 in response to LPS.

Go back
565.0, 317.0
21.0, 21.0

p103

p103

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016882 e116

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c288 : 1
stoichiometry:c289 : 1

m155666*m117*0.1

nodelay

--

true

0

false

PMID: 17456803,2511200 Further, LPS stimulation caused G{alpha}i2 phosphorylation in these cells, implicating this G-protein as a player in LPS signaling

Go back
942.0, 746.0
19.0, 19.0

p104

p104

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000016882 e115

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c292 : 1
stoichiometry:c291 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17456803,8423328,2844658 In mouse peritoneal macrophages, PTx inhibited LPS-dependent NO production but amplified TNF protein production, although others reported no effect of this inhibitor on TNF secretion

Go back
406.0, 834.0
19.0, 19.0

p105

p105

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e41 MO000016882 e115

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1
stoichiometry:c294 : 1

m41*m155666*m116*0.1

nodelay

--

true

0

false

Go back
477.0, 537.0
22.0, 22.0

p106

p106

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e119 MO000016882 e115

MO000000022

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c299 : 1
stoichiometry:c300 : 1
stoichiometry:c298 : 1

m121*m155666*0.1

nodelay

--

true

0

false

PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation

Go back
405.0, 617.0
22.0, 22.0

p106

p107

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016882 MO000004670 e115 e184

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c304 : 1
stoichiometry:c308 : 1
stoichiometry:c441 : 1
stoichiometry:c305 : 1

m155666*m549*0.1

nodelay

--

true

0

false

PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation

Go back
525.0, 525.0
22.0, 22.0

p106

p108

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016882 MO000004676 e115 e184

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c302 : 1
stoichiometry:c306 : 1
stoichiometry:c309 : 1
stoichiometry:c442 : 1
stoichiometry:c307 : 1

m155666*m554*0.1

nodelay

--

true

0

false

PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation

Go back
601.0, 521.0
22.0, 22.0

p106

p109

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016882 e115 MO000000276

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1

m155666*m219*0.1

nodelay

--

true

0

false

PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation

Go back
245.0, 213.0
22.0, 22.0

p3

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 e12

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m23*m12*0.1

nodelay

--

true

0

false

PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.

Go back
470.0, 686.0
19.0, 19.0

p110

p110

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e41 e124

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c315 : 1
stoichiometry:c314 : 1

m41*m126*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
566.0, 654.0
19.0, 19.0

p110

p111

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e41 e116

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c316 : 1
stoichiometry:c318 : 1
stoichiometry:c317 : 1

m41*m117*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
626.0, 686.0
19.0, 19.0

p110

p112

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e123 e41

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c320 : 1
stoichiometry:c321 : 1

m125*m41*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
670.0, 690.0
19.0, 19.0

p110

p113

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e103 e123

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c323 : 1
stoichiometry:c324 : 1

m104*m125*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
615.0, 639.0
21.0, 21.0

p110

p114

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e103 e116

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c325 : 1
stoichiometry:c326 : 1
stoichiometry:c327 : 1

m104*m117*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
505.0, 637.0
21.0, 21.0

p110

p115

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e103 e124

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c328 : 1
stoichiometry:c329 : 1
stoichiometry:c330 : 1

m104*m126*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
701.0, 721.0
21.0, 21.0

p116

p116

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e126 e124

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c331 : 1
stoichiometry:c333 : 1
stoichiometry:c332 : 1

m128*m126*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
1001.0, 629.0
21.0, 21.0

p116

p117

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e126 e123

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c334 : 1
stoichiometry:c335 : 1
stoichiometry:c336 : 1

m128*m125*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
745.0, 685.0
21.0, 21.0

p116

p118

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e126 e116

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1

m128*m117*0.1

nodelay

--

true

0

false

PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3

Go back
272.0, 648.0
23.0, 23.0

p119

p119

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 MO000000058

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c339 : 1
stoichiometry:c340 : 1
stoichiometry:c341 : 1

m35*m129*0.1

nodelay

--

true

0

false

PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B

Go back
213.0, 337.0
21.0, 21.0

p4

p12

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytosol

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.

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264.0, 360.0
23.0, 23.0

p119

p120

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e128 MO000000058

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c342 : 1
stoichiometry:c343 : 1
stoichiometry:c344 : 1

m131*m129*0.1

nodelay

--

true

0

false

PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B

Go back
292.0, 280.0
23.0, 23.0

p119

p121

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e129 MO000000058

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c345 : 1
stoichiometry:c346 : 1
stoichiometry:c347 : 1

m132*m129*0.1

nodelay

--

true

0

false

PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B

Go back
656.0, 440.0
23.0, 23.0

p119

p122

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e130 MO000000058

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c348 : 1
stoichiometry:c349 : 1
stoichiometry:c350 : 1

m133*m129*0.1

nodelay

--

true

0

false

PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B

Go back
476.0, 324.0
23.0, 23.0

p119

p123

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e131 MO000000058

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c351 : 1
stoichiometry:c352 : 1
stoichiometry:c353 : 1

m134*m129*0.1

nodelay

--

true

0

false

PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B

Go back
917.0, 349.0
21.0, 21.0

p124

p124

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e132 e133 MO000013119

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c354 : 1
stoichiometry:c355 : 1
stoichiometry:c359 : 1
stoichiometry:c356 : 1

m135*m136*m1357*0.1

nodelay

--

true

0

false

PMID: 17456803,11046044,11301323,16382134 Gbeta2L1 also has roles beyond regulation of GPCR signaling; it mediated the recruitment of STAT1 and STAT3 to the IFN-{alpha}/beta and the tyrosine kinase insulin-like growth factor receptor 1 (IGFR-1) receptors, respectively

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893.0, 409.0
21.0, 21.0

p124

p125

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e135 e132 MO000013119

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c357 : 1
stoichiometry:c358 : 1
stoichiometry:c360 : 1
stoichiometry:c361 : 1

m138*m135*m1357*0.1

nodelay

--

true

0

false

PMID: 17456803,11046044,11301323,16382134 Gbeta2L1 also has roles beyond regulation of GPCR signaling; it mediated the recruitment of STAT1 and STAT3 to the IFN-{alpha}/beta and the tyrosine kinase insulin-like growth factor receptor 1 (IGFR-1) receptors, respectively

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653.0, 345.0
21.0, 21.0

p124

p126

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e137 e132 MO000013122

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c363 : 1
stoichiometry:c365 : 1
stoichiometry:c364 : 1

m140*m135*m1360*0.1

nodelay

--

true

0

false

PMID: 17456803,11046044,11301323,16382134 Gbeta2L1 also has roles beyond regulation of GPCR signaling; it mediated the recruitment of STAT1 and STAT3 to the IFN-{alpha}/beta and the tyrosine kinase insulin-like growth factor receptor 1 (IGFR-1) receptors, respectively

Go back
410.0, 1146.0
19.0, 19.0

p127

p127

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016882

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c366 : 1
stoichiometry:c367 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17456803,11886441 In addition, Hausmann et al. showed that LPS and TNF increased RGS7 mRNA levels markedly in the macrophage-like cell line RAW264.7

Go back
386.0, 1010.0
19.0, 19.0

p127

p128

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000204

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c368 : 1
stoichiometry:c369 : 1

m175*0.1

nodelay

--

true

0

false

PMID: 17456803,11886441 In addition, Hausmann et al. showed that LPS and TNF increased RGS7 mRNA levels markedly in the macrophage-like cell line RAW264.7

Go back
897.0, 1317.0
21.0, 21.0

p129

p129

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000069674 e140

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c370 : 1
stoichiometry:c371 : 1
stoichiometry:c372 : 1

m44517*m143*0.1

nodelay

--

true

0

false

PMID: 17456803, 9770488 RGS19 [also known as Galpha-interacting protein (GAIP) interacts specifically with the PDZ-containing protein, GAIP-interacting protein, C-terminus (GIPC)

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250.0, 394.0
19.0, 19.0

p5

p13

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e25

e17 e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 17456803 The GTP-bound {alpha}-subunit dissociates from the beta{gamma}-subunit; the free subunits then regulate effector enzymes positively or negatively, ultimately leading to a biological response.

Go back
1009.0, 1609.0
21.0, 21.0

p130

p130

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e141 e142

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c373 : 1
stoichiometry:c374 : 1
stoichiometry:c375 : 1

m144*m145*0.1

nodelay

--

true

0

false

PMID: 17456803, 11751850 Interaction of the RGS19/GIPC heterodimer with the IGFR-1 consolidates IGF-1 signaling to MAPK activation

Go back
948.0, 1616.0
23.0, 23.0

p131

p131

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e143 MO000016894

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c376 : 1
stoichiometry:c377 : 1
stoichiometry:c378 : 1

m146*m1812*0.1

nodelay

--

true

0

false

PMID: 17456803, 11751850 Interaction of the RGS19/GIPC heterodimer with the IGFR-1 consolidates IGF-1 signaling to MAPK activation

Go back
1138.0, 1738.0
19.0, 19.0

p132

p132

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e141 MO000017023

e145

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c379 : 1
stoichiometry:c380 : 1
stoichiometry:c381 : 1

m144*m1922*0.1

nodelay

--

true

0

false

PMID: 17456803, 11251075 RGS19 and GAIC can also form a complex with the nerve growth factor receptor, TrkA, , although it remains unclear how this complex affects signaling through these receptors.

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634.0, 1118.0
20.0, 20.0

p133

p133

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016882

e146

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c382 : 1
stoichiometry:c383 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17456803 Array data suggest that GRK2 and -6 mRNA expression is down-regulated by LPS in bone marrow-derived macrophages

Go back
606.0, 1118.0
20.0, 20.0

p133

p134

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016882

e161

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c385 : 1
stoichiometry:c384 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17456803 Array data suggest that GRK2 and -6 mRNA expression is down-regulated by LPS in bone marrow-derived macrophages

Go back
721.0, 1377.0
21.0, 21.0

p135

p135

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e147 MO000016597 MO000016882

MO000017111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c386 : 1
stoichiometry:c391 : 1
stoichiometry:c396 : 1
stoichiometry:c387 : 1

m150*m1591*0.1

nodelay

--

true

0

false

PMID: 17456803, 11861327, 12130691, 10094932 Protein expression of GRK2 and -5 was elevated in the lungs of IL-1beta-treated rats while oxygen radicals and the inflammatory cytokines, IL-6 and IFN, reduced GRK2 protein in human T lymphocytes and human PBMC, respectively PMID: 17456803, 12592402 Furthermore, GRK2 and -5 protein expression was down-regulated by LPS in polymorphonuclear neutrophils, thereby augmenting chemokine responsiveness

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801.0, 1405.0
21.0, 21.0

p135

p136

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e146 e86 MO000007384 MO000016597 e162 MO000016882

MO000017093

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c389 : 1
stoichiometry:c392 : 1
stoichiometry:c393 : 1
stoichiometry:c388 : 1
stoichiometry:c394 : 1
stoichiometry:c395 : 1
stoichiometry:c390 : 1

m149*m1591*0.1

nodelay

--

true

0

false

PMID: 17456803, 11861327, 12130691, 10094932 Protein expression of GRK2 and -5 was elevated in the lungs of IL-1beta-treated rats while oxygen radicals and the inflammatory cytokines, IL-6 and IFN, reduced GRK2 protein in human T lymphocytes and human PBMC, respectively PMID: 17456803, 11861327, 12130691, 10094932 Protein expression of GRK2 and -5 was elevated in the lungs of IL-1beta-treated rats while oxygen radicals and the inflammatory cytokines, IL-6 and IFN, reduced GRK2 protein in human T lymphocytes and human PBMC, respectively PMID: 17456803, 12592402 Furthermore, GRK2 and -5 protein expression was down-regulated by LPS in polymorphonuclear neutrophils, thereby augmenting chemokine responsiveness

Go back
642.0, 78.0
19.0, 19.0

p137

p137

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000017069 MO000017075

e163

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c397 : 1
stoichiometry:c398 : 1
stoichiometry:c399 : 1

m1961*m1967*0.1

nodelay

--

true

0

false

PMID: 17456803, 9575184, 10852916, 10884381 First, GRKs are able to phosphorylate nonreceptor substrates such as tubulin, synucleins and phosducin

Go back
702.0, 82.0
19.0, 19.0

p137

p138

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000017069 e164

e165

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c400 : 1
stoichiometry:c401 : 1
stoichiometry:c402 : 1

m1961*m167*0.1

nodelay

--

true

0

false

PMID: 17456803, 9575184, 10852916, 10884381 First, GRKs are able to phosphorylate nonreceptor substrates such as tubulin, synucleins and phosducin

Go back
782.0, 78.0
19.0, 19.0

p137

p139

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000017069 e166

e167

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c403 : 1
stoichiometry:c404 : 1
stoichiometry:c405 : 1

m1961*m169*0.1

nodelay

--

true

0

false

PMID: 17456803, 9575184, 10852916, 10884381 First, GRKs are able to phosphorylate nonreceptor substrates such as tubulin, synucleins and phosducin

Go back
266.0, 310.0
19.0, 19.0

p6

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017069 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m1961*m26*0.1

nodelay

--

true

0

false

PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases

Go back
745.0, 465.0
21.0, 21.0

p140

p140

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017069 e168

e169

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c406 : 1
stoichiometry:c407 : 1
stoichiometry:c408 : 1

m1961*m171*0.1

nodelay

--

true

0

false

PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT

Go back
821.0, 545.0
21.0, 21.0

p140

p141

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e170 MO000017069

e171

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c409 : 1
stoichiometry:c410 : 1
stoichiometry:c411 : 1

m173*m1961*0.1

nodelay

--

true

0

false

PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT

Go back
853.0, 465.0
21.0, 21.0

p140

p142

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017069 e172

e173

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c412 : 1
stoichiometry:c413 : 1
stoichiometry:c414 : 1

m1961*m176*0.1

nodelay

--

true

0

false

PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT

Go back
337.0, 345.0
21.0, 21.0

p140

p143

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000017069

e174

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c415 : 1
stoichiometry:c416 : 1
stoichiometry:c417 : 1

m5*m1961*0.1

nodelay

--

true

0

false

PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT

Go back
1033.0, 545.0
21.0, 21.0

p140

p144

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000011 MO000017069

e175

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c418 : 1
stoichiometry:c419 : 1
stoichiometry:c420 : 1

m179*m1961*0.1

nodelay

--

true

0

false

PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT

Go back
865.0, 569.0
21.0, 21.0

p140

p145

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000048 MO000017069

e176

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c421 : 1
stoichiometry:c422 : 1
stoichiometry:c423 : 1

m181*m1961*0.1

nodelay

--

true

0

false

PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT

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957.0, 825.0
21.0, 21.0

p146

p146

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017093 e5

e177

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c424 : 1
stoichiometry:c425 : 1
stoichiometry:c426 : 1

m1984*m5*0.1

nodelay

--

true

0

false

PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling

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785.0, 769.0
21.0, 21.0

p146

p147

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e178

e179

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c427 : 1
stoichiometry:c428 : 1
stoichiometry:c429 : 1

m5*m184*0.1

nodelay

--

true

0

false

PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling

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857.0, 681.0
21.0, 21.0

p146

p148

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e178 e172

e180

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c430 : 1
stoichiometry:c431 : 1
stoichiometry:c432 : 1

m184*m176*0.1

nodelay

--

true

0

false

PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling

Go back
1029.0, 713.0
21.0, 21.0

p146

p149

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e172 MO000017093

e181

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c433 : 1
stoichiometry:c434 : 1
stoichiometry:c435 : 1

m176*m1984*0.1

nodelay

--

true

0

false

PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling

Go back
266.0, 498.0
19.0, 19.0

p6

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e19 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m19*m26*0.1

nodelay

--

true

0

false

PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases

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581.0, 1541.0
21.0, 21.0

p150

p150

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017111 e182

e183

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c436 : 1
stoichiometry:c437 : 1
stoichiometry:c438 : 1

m1999*m189*0.1

nodelay

--

true

0

false

PMID: 17456803, 16980301 GRK5 also bound to and phosphorylated p105, implying that p105 phosphorylation by GRK5 negatively regulates LPS-stimulated ERK activation

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765.0, 1553.0
21.0, 21.0

p151

p151

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e183

e184

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c439 : 1
stoichiometry:c440 : 1

m190*0.1

nodelay

--

true

0

false

Go back
1070.0, 482.0
19.0, 19.0

p152

p152

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e186 e185 MO000017074

e187

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c443 : 1
stoichiometry:c444 : 1
stoichiometry:c445 : 1
stoichiometry:c446 : 1

m193*m192*m1966*0.1

nodelay

--

true

0

false

PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1

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1129.0, 453.0
21.0, 21.0

p153

p153

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e188 e187 MO000000011

e189

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c447 : 1
stoichiometry:c448 : 1
stoichiometry:c449 : 1
stoichiometry:c450 : 1

m195*m194*m179*0.1

nodelay

--

true

0

false

PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1

Go back
1205.0, 421.0
21.0, 21.0

p153

p154

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e190 e187 MO000000011

e189

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c451 : 1
stoichiometry:c452 : 1
stoichiometry:c453 : 1
stoichiometry:c454 : 1

m197*m194*m179*0.1

nodelay

--

true

0

false

PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1

Go back
1245.0, 645.0
21.0, 21.0

p153

p155

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e191 e187 MO000000011

e189

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c455 : 1
stoichiometry:c456 : 1
stoichiometry:c457 : 1
stoichiometry:c458 : 1

m198*m194*m179*0.1

nodelay

--

true

0

false

PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1

Go back
1165.0, 713.0
21.0, 21.0

p153

p156

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e192 e187 MO000000011

e189

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c459 : 1
stoichiometry:c460 : 1
stoichiometry:c461 : 1
stoichiometry:c462 : 1

m199*m194*m179*0.1

nodelay

--

true

0

false

PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1

Go back
789.0, 1037.0
21.0, 21.0

p157

p157

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017072 e194

e193

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c464 : 1
stoichiometry:c463 : 1
stoichiometry:c465 : 1

m1964*m201*0.1

nodelay

--

true

0

false

PMID: 17456803, 12821670, 10725339 Further, direct binding of ARRB to ERK enhanced ERK phosphorylation and targeted it to the cytosol

Go back
766.0, 1202.0
19.0, 19.0

p158

p158

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e193

e195

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c466 : 1
stoichiometry:c467 : 1

m200*0.1

nodelay

--

true

0

false

PMID: 17456803, 12821670, 10725339 Further, direct binding of ARRB to ERK enhanced ERK phosphorylation and targeted it to the cytosol

Go back
1114.0, 726.0
19.0, 19.0

p159

p159

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e195

MO000000011 e196

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c468 : 1
stoichiometry:c469 : 1
stoichiometry:c470 : 1

m202*0.1

nodelay

--

true

0

false

PMID: 17456803, 12821670, 10725339 Further, direct binding of ARRB to ERK enhanced ERK phosphorylation and targeted it to the cytosol

Go back
970.0, 286.0
19.0, 19.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 e21

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m18*m21*0.1

nodelay

--

true

0

false

PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.

Go back
845.0, 1569.0
21.0, 21.0

p160

p160

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017818 MO000017074

e197

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c471 : 1
stoichiometry:c473 : 1
stoichiometry:c472 : 1

m2570*m1966*0.1

nodelay

--

true

0

false

PMID: 17456803, 11356842 ARRB2, but not ARRB1, activated JNK3 signaling through its ability to act as a scaffold

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68.0, 1748.0
23.0, 23.0

p161

p161

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e198

e199

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c474 : 1
stoichiometry:c475 : 1

m205*0.1

nodelay

--

true

0

false

PMID: 17456803, 11756160, 9710599 Activation of a number of receptor tyrosine kinases, including the CSF-1 receptor, which is required for macrophage survival and proliferation , leads to activation of ERK1/2.

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304.0, 1616.0
23.0, 23.0

p161

p162

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e199 MO000004670

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c476 : 1
stoichiometry:c477 : 1
stoichiometry:c478 : 1

m206*m549*0.1

nodelay

--

true

0

false

PMID: 17456803, 11756160, 9710599 Activation of a number of receptor tyrosine kinases, including the CSF-1 receptor, which is required for macrophage survival and proliferation , leads to activation of ERK1/2.

Go back
228.0, 1612.0
23.0, 23.0

p161

p163

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e199 MO000004676

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c479 : 1
stoichiometry:c481 : 1
stoichiometry:c480 : 1

m206*m554*0.1

nodelay

--

true

0

false

PMID: 17456803, 11756160, 9710599 Activation of a number of receptor tyrosine kinases, including the CSF-1 receptor, which is required for macrophage survival and proliferation , leads to activation of ERK1/2.

Go back
1054.0, 1402.0
19.0, 19.0

p164

p164

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017818 MO000017074

e200

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c482 : 1
stoichiometry:c483 : 1
stoichiometry:c484 : 1

m2570*m1966*0.1

nodelay

--

true

0

false

--

Go back
957.0, 1761.0
21.0, 21.0

p165

p165

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e201 e200

e202

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c485 : 1
stoichiometry:c486 : 1
stoichiometry:c487 : 1

m208*m207*0.1

nodelay

--

true

0

false

PMID: 17456803 The interaction among JNK3, ARRB2 and ASK1 resulted in the assembly of signaling complexes and enhanced phosphorylation of JNK3.

Go back
1233.0, 305.0
21.0, 21.0

p166

p166

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e196 MO000000058

e203

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c488 : 1
stoichiometry:c489 : 1
stoichiometry:c490 : 1

m203*m129*0.1

nodelay

--

true

0

false

PMID: 17456803 ARRBs also regulate macrophage signaling through interaction with NF-{kappa}B, a family of proinflammatory transcription factors.

Go back
1061.0, 741.0
21.0, 21.0

p167

p167

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e204 MO000017073

e205

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c491 : 1
stoichiometry:c492 : 1
stoichiometry:c493 : 1

m211*m1965*0.1

nodelay

--

true

0

false

PMID: 17456803,15125834,15173580 ARRB1 and -2 interacted with the I{kappa}B{alpha} component of the NF-{kappa}B signaling complex in a range of cell types including HEK293, HeLa, Jurkat, COS-7 and THP-1 cells

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392.0, 1308.0
23.0, 23.0

p168

p168

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 MO000000204 MO000017073

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c498 : 1
stoichiometry:c497 : 1
stoichiometry:c500 : 1
stoichiometry:c499 : 1

m129*m175*0.1

nodelay

--

true

0

false

PMID: 17456803, 15173580 Overexpression of ARRB1 or -2 in HeLa cells inhibited TNF-induced NF-{kappa}B activation

Go back
1017.0, 909.0
21.0, 21.0

p167

p169

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017074 e204

e206

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c494 : 1
stoichiometry:c495 : 1
stoichiometry:c496 : 1

m1966*m211*0.1

nodelay

--

true

0

false

PMID: 17456803,15125834,15173580 ARRB1 and -2 interacted with the I{kappa}B{alpha} component of the NF-{kappa}B signaling complex in a range of cell types including HEK293, HeLa, Jurkat, COS-7 and THP-1 cells

Go back
226.0, 450.0
19.0, 19.0

p16

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 e20

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m27*m20*0.1

nodelay

--

true

0

false

PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.

Go back
412.0, 576.0
23.0, 23.0

p168

p170

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000204 MO000000058 MO000017074

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c501 : 1
stoichiometry:c502 : 1
stoichiometry:c504 : 1
stoichiometry:c503 : 1

m175*m129*0.1

nodelay

--

true

0

false

PMID: 17456803, 15173580 Overexpression of ARRB1 or -2 in HeLa cells inhibited TNF-induced NF-{kappa}B activation

Go back
501.0, 1217.0
21.0, 21.0

p171

p171

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e207 e208 MO000017074

e209

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c505 : 1
stoichiometry:c506 : 1
stoichiometry:c508 : 1
stoichiometry:c507 : 1

m214*m215*0.1

nodelay

--

true

0

false

PMID: 17456803,15125834 Similarly, overexpression of ARRB2 in HEK293 cells inhibited TNF-induced NF-{kappa}B DNA binding, while RNA interference-mediated knockdown of ARRB2 had an opposing effect

Go back
308.0, 1860.0
23.0, 23.0

p172

p172

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e210 e216 e218 e219

e211

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c509 : 1
stoichiometry:c511 : 1
stoichiometry:c527 : 1
stoichiometry:c536 : 1
stoichiometry:c510 : 1

m218*m225*0.1

nodelay

--

true

0

false

PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation

Go back
408.0, 1800.0
23.0, 23.0

p173

p173

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e211

e212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c512 : 1
stoichiometry:c513 : 1

m220*0.1

nodelay

--

true

0

false

PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK

Go back
349.0, 1677.0
21.0, 21.0

p174

p174

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e212 MO000000023

e213

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c514 : 1
stoichiometry:c515 : 1
stoichiometry:c516 : 1

m221*m217*0.1

nodelay

--

true

0

false

PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK

Go back
244.0, 1708.0
23.0, 23.0

p172

p175

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e210 e217

e211

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c517 : 1
stoichiometry:c519 : 1
stoichiometry:c518 : 1

m218*m226*0.1

nodelay

--

true

0

false

PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK

Go back
589.0, 1773.0
21.0, 21.0

p174

p176

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e212 e215

e214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c520 : 1
stoichiometry:c521 : 1
stoichiometry:c522 : 1

m221*m224*0.1

nodelay

--

true

0

false

PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK

Go back
361.0, 1597.0
21.0, 21.0

p177

p177

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e210 e217 MO000017073

e218

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c523 : 1
stoichiometry:c524 : 1
stoichiometry:c525 : 1
stoichiometry:c526 : 1

m218*m226*m1965*0.1

nodelay

--

true

0

false

PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation

Go back
409.0, 1637.0
21.0, 21.0

p177

p178

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e216 MO000017073 e210

e218

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c528 : 1
stoichiometry:c529 : 1
stoichiometry:c530 : 1
stoichiometry:c531 : 1

m225*m1965*m218*0.1

nodelay

--

true

0

false

PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation

Go back
801.0, 1737.0
21.0, 21.0

p177

p179

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e210 e217 MO000017074

e219

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c532 : 1
stoichiometry:c533 : 1
stoichiometry:c534 : 1
stoichiometry:c535 : 1

m218*m226*m1966*0.1

nodelay

--

true

0

false

PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation

Go back
254.0, 538.0
19.0, 19.0

p16

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 e21

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m27*m21*0.1

nodelay

--

true

0

false

PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.

Go back
749.0, 1777.0
21.0, 21.0

p177

p180

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e210 e216 MO000017074

e219

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c537 : 1
stoichiometry:c538 : 1
stoichiometry:c539 : 1
stoichiometry:c540 : 1

m218*m225*m1966*0.1

nodelay

--

true

0

false

PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation

Go back
1058.0, 370.0
19.0, 19.0

p16

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 e20

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m18*m20*0.1

nodelay

--

true

0

false

PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.

Go back
354.0, 74.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000314 e6

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m249*m6*0.1

nodelay

--

true

0

false

PMID: 17456803 Figure 1

Go back
993.0, 397.0
21.0, 21.0

p20

p20

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e28

MO000017074 e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization

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1057.0, 405.0
21.0, 21.0

p20

p21

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e31

MO000017073 e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization

Go back
928.0, 448.0
23.0, 23.0

p22

p22

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

e18

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization PMID: 17456803 Figure 1

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224.0, 580.0
23.0, 23.0

p22

p23

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

e30

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization PMID: 17456803 Figure 1

Go back
272.0, 568.0
23.0, 23.0

p22

p24

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

e29

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization PMID: 17456803 Figure 1

Go back
86.0, 790.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033607 MO000022274

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m12280*m6571*0.1

nodelay

--

true

0

false

PMID: 17456803,8011297 The complement component C5a acts as a potent neutrophil and monocyte chemoattractant via the GPCR C5aR/CD88

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82.0, 842.0
19.0, 19.0

p25

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033607 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m12280*m36*0.1

nodelay

--

true

0

false

PMID: 17456803,8011297 The complement component C5a acts as a potent neutrophil and monocyte chemoattractant via the GPCR C5aR/CD88

Go back
449.0, 949.0
21.0, 21.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G030823

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17456803,12176911 It also up-regulates the expression of other complement receptors such as CR1 and CR3 on leukocytes, thus enhancing phagocytic capacity and the respiratory burst

Go back
517.0, 889.0
21.0, 21.0

p27

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G012063

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17456803,12176911 It also up-regulates the expression of other complement receptors such as CR1 and CR3 on leukocytes, thus enhancing phagocytic capacity and the respiratory burst

Go back
265.0, 733.0
21.0, 21.0

p29

p29

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e35

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17456803,6300969,1690130,6809882 Further, C5a triggered the production of superoxide anion and PGE2 from resident and elicited mouse peritoneal macrophages, as well as TNF and IL-1 from human and mouse macrophage populations

Go back
501.0, 233.0
22.0, 22.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e12

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m12*0.1

nodelay

--

true

0

false

PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.

Go back
301.0, 669.0
21.0, 21.0

p29

p30

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e35

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17456803,6300969,1690130,6809882 Further, C5a triggered the production of superoxide anion and PGE2 from resident and elicited mouse peritoneal macrophages, as well as TNF and IL-1 from human and mouse macrophage populations

Go back
313.0, 1005.0
21.0, 21.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e35 e40

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m35*m40*0.1

nodelay

--

true

0

false

Go back
325.0, 945.0
21.0, 21.0

p31

p32

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e41

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m41*0.1

nodelay

--

true

0

false

Go back
1445.0, 645.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 e42

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m43*m42*0.1

nodelay

--

true

0

false

PMID: 17456803 FPR1 triggers cellular locomotion upon recognition of N-formylated methionine from bacterial proteins.

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1458.0, 730.0
19.0, 19.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 e42

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m45*m42*0.1

nodelay

--

true

0

false

PMID: 17456803,16684671,2161213,8198572 The classic FPR1 agonist, fMLP, has a much higher affinity for FPR1 than FPRL1, and ectopic expression studies suggest that FPRL2 does not recognize this ligand

Go back
1446.0, 902.0
19.0, 19.0

p34

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063316 e45

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m38196*m45*0.1

nodelay

--

true

0

false

PMID: 17456803,16684671,2161213,8198572 The classic FPR1 agonist, fMLP, has a much higher affinity for FPR1 than FPRL1, and ectopic expression studies suggest that FPRL2 does not recognize this ligand

Go back
1222.0, 954.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 MO000033549

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m48*m12225*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
1538.0, 486.0
19.0, 19.0

p36

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m42*m63*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
1538.0, 670.0
20.0, 20.0

p36

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000063316

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m63*m38196*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
1134.0, 998.0
19.0, 19.0

p36

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 e42

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m66*m42*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
601.0, 225.0
21.0, 21.0

p4

p4

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytosol

--

e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.

Go back
1066.0, 1138.0
19.0, 19.0

p36

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063316 e66

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m38196*m66*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
998.0, 1286.0
19.0, 19.0

p36

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m42*m69*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
1102.0, 1242.0
19.0, 19.0

p36

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000063316

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m69*m38196*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
1130.0, 1370.0
19.0, 19.0

p36

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 e42

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m72*m42*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
1038.0, 1310.0
19.0, 19.0

p36

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000063316

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m72*m38196*0.1

nodelay

--

true

0

false

PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues

Go back
673.0, 905.0
21.0, 21.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e46

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC

Go back
941.0, 961.0
21.0, 21.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010514

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m93479*0.1

nodelay

--

true

0

false

PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC

Go back
1209.0, 1469.0
21.0, 21.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e47 MO000017281

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m47*m2134*0.1

nodelay

--

true

0

false

PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4

Go back
1057.0, 1457.0
21.0, 21.0

p47

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e46 MO000017281

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m46*m2134*0.1

nodelay

--

true

0

false

PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4

Go back
1173.0, 1557.0
21.0, 21.0

p47

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e46 MO000017157

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m46*m2033*0.1

nodelay

--

true

0

false

PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4

Go back
718.0, 234.0
19.0, 19.0

p5

p5

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e15

e17 e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17456803 The GTP-bound {alpha}-subunit dissociates from the beta{gamma}-subunit; the free subunits then regulate effector enzymes positively or negatively, ultimately leading to a biological response.

Go back
1113.0, 1613.0
21.0, 21.0

p47

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e47 MO000017157

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m47*m2033*0.1

nodelay

--

true

0

false

PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4

Go back
77.0, 1049.0
21.0, 21.0

p51

p51

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 17456803 The PARs are a family of GPCRs that are activated upon proteolytic cleavage of their amino terminal exodomain.

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49.0, 1137.0
21.0, 21.0

p52

p52

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

MO000017008 MO000013668

MO000018417

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m1909*m1420*0.1

nodelay

--

true

0

false

PMID: 17456803,12805069,16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
957.0, 1057.0
21.0, 21.0

p46

p53

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e46

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m93364*m46*0.1

nodelay

--

true

0

false

PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC

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953.0, 1113.0
21.0, 21.0

p46

p54

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e80 e46

MO000016589

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m80*m46*0.1

nodelay

--

true

0

false

PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC

Go back
865.0, 897.0
21.0, 21.0

p46

p55

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e46

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m93248*m46*0.1

nodelay

--

true

0

false

PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC

Go back
57.0, 1269.0
21.0, 21.0

p52

p56

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

MO000017008 MO000017020

MO000017394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m1909*m1920*0.1

nodelay

--

true

0

false

PMID: 17456803,12805069,16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
828.0, 768.0
23.0, 23.0

p57

p57

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 MO000018417

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m93248*m3055*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
828.0, 832.0
23.0, 23.0

p57

p58

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000017394 G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m2226*m93248*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
920.0, 1208.0
23.0, 23.0

p59

p59

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010815 MO000018417

MO000017280

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m93710*m3055*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
846.0, 230.0
19.0, 19.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e16 MO000017069

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1

m16*m1961*0.1

nodelay

--

true

0

false

PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases

Go back
876.0, 1232.0
23.0, 23.0

p59

p60

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000017394 G010815

MO000017280

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m2226*m93710*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
73.0, 1373.0
21.0, 21.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017020 e81

MO000017394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c168 : 1
stoichiometry:c167 : 1

m1920*m81*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
992.0, 1084.0
23.0, 23.0

p59

p62

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000017394 G010389

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m2226*m93364*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
880.0, 928.0
23.0, 23.0

p59

p63

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 MO000017394

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c173 : 1

m93248*m2226*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
984.0, 1136.0
23.0, 23.0

p59

p64

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e82 MO000017394

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1
stoichiometry:c176 : 1

m82*m2226*0.1

nodelay

--

true

0

false

PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8

Go back
73.0, 1417.0
21.0, 21.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e84 e83

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m84*m83*0.1

nodelay

--

true

0

false

PMID: 17456803,1380279,9548509 Rodent and human macrophages express the neurokinin-1 receptor (NK-1R or TACR1), which signals in response to neuropeptide substance P (SP)

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273.0, 1029.0
21.0, 21.0

p66

p66

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e85 e41

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m85*m41*0.1

nodelay

--

true

0

false

PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages

Go back
205.0, 1129.0
21.0, 21.0

p66

p67

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e85

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m40*m85*0.1

nodelay

--

true

0

false

PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages

Go back
845.0, 845.0
21.0, 21.0

p66

p68

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e85 G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m85*m93248*0.1

nodelay

--

true

0

false

PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages

Go back
254.0, 1470.0
19.0, 19.0

p69

p69

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages

Go back
910.0, 234.0
19.0, 19.0

p6

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e16 e19

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1

m16*m19*0.1

nodelay

--

true

0

false

PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases

Go back
266.0, 1426.0
19.0, 19.0

p69

p70

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e85

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages

Go back
541.0, 1361.0
21.0, 21.0

p71

p71

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000016882 G011075

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m155666*m93961*0.1

nodelay

--

true

0

false

PMID: 17456803,1380279,9548509,10573219 Expression of NK-1R and SP protein was induced in rat and human macrophages in response to LPS , suggesting the existence of an autocrine pathway

Go back
405.0, 1361.0
21.0, 21.0

p71

p72

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000016882 e88

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m155666*m88*0.1

nodelay

--

true

0

false

PMID: 17456803,1380279,9548509,10573219 Expression of NK-1R and SP protein was induced in rat and human macrophages in response to LPS , suggesting the existence of an autocrine pathway

Go back
453.0, 1413.0
21.0, 21.0

p73

p73

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e89

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 17456803,9761426 In vitro stimulation of murine peritoneal macrophages with ET-1 induced cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production

Go back
606.0, 1262.0
20.0, 20.0

p74

p74

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 17456803,9761426 In vitro stimulation of murine peritoneal macrophages with ET-1 induced cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production

Go back
237.0, 961.0
21.0, 21.0

p75

p75

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e89 e41

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c206 : 1
stoichiometry:c205 : 1

m89*m41*0.1

nodelay

--

true

0

false

PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6

Go back
921.0, 1161.0
21.0, 21.0

p31

p76

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e89 e82

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m89*m82*0.1

nodelay

--

true

0

false

PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6

Go back
913.0, 993.0
21.0, 21.0

p31

p77

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010262 e89

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c211 : 1

m93248*m89*0.1

nodelay

--

true

0

false

PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6

Go back
937.0, 1013.0
21.0, 21.0

p31

p78

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e89 G010389

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m89*m93364*0.1

nodelay

--

true

0

false

PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6

Go back
861.0, 1329.0
21.0, 21.0

p31

p79

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e91 e89

MO000000099

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c218 : 1
stoichiometry:c217 : 1

m92*m89*0.1

nodelay

--

true

0

false

PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6

Go back
957.0, 317.0
21.0, 21.0

p8

p8

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000017073

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m1965*0.1

nodelay

--

true

0

false

PMID: 17456803,11777907,10770944,15498833 This phosphorylation promotes translocation of the cytosolic adaptor arrestin proteins to the membrane, where they bind to the receptor and promote internalization through interaction with Beta2-adaptin and clathrin components of the endocytic machinery

Go back
277.0, 1081.0
21.0, 21.0

p80

p80

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e92 e41

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m93*m41*0.1

nodelay

--

true

0

false

PMID: 17456803,9444616 For example, ET-1 treatment of the macrophage cell line J774.2 increased TNF secretion via the ETAR

Go back
589.0, 1345.0
21.0, 21.0

p81

p81

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e94 e89

MO000021803

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c224 : 1
stoichiometry:c223 : 1

m95*m89*0.1

nodelay

--

true

0

false

PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells

Go back
645.0, 1373.0
21.0, 21.0

p81

p82

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e94 e93

MO000021803

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c225 : 1
stoichiometry:c227 : 1

m95*m94*0.1

nodelay

--

true

0

false

PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells

Go back
685.0, 1349.0
21.0, 21.0

p81

p83

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e89 e95

MO000021957

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m89*m96*0.1

nodelay

--

true

0

false

PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells

Go back
769.0, 1361.0
21.0, 21.0

p81

p84

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e93 e95

MO000021957

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m94*m96*0.1

nodelay

--

true

0

false

PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells

Go back
317.0, 1561.0
21.0, 21.0

p85

p85

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e89

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 17456803,8825394 ET-1 can also influence the production of superoxides by macrophages; ET-1 primed O2? production from rabbit alveolar macrophages

Go back
385.0, 1561.0
21.0, 21.0

p85

p86

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e89

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c237 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 17456803,8825394 ET-1 can also influence the production of superoxides by macrophages; ET-1 primed O2? production from rabbit alveolar macrophages

Go back
469.0, 1113.0
21.0, 21.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016882 e98

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c240 : 1
stoichiometry:c239 : 1

m155666*m99*0.1

nodelay

--

true

0

false

PMID: 17456803,10338485,10534342,7693362 PAF antagonists inhibited LPS-regulated iNOS mRNA expression and NO production in murine macrophages and rat Kupffer cells, implying an involvement of autocrine PAF in LPS responses

Go back
238.0, 1338.0
19.0, 19.0

p88

p88

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e99 MO000021432

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c243 : 1

m100*m5783*0.1

nodelay

--

true

0

false

PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages

Go back
302.0, 1482.0
19.0, 19.0

p88

p89

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e100 MO000021432

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1
stoichiometry:c246 : 1

m101*m5783*0.1

nodelay

--

true

0

false

PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages

Go back
993.0, 349.0
21.0, 21.0

p8

p9

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000017074

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m1966*0.1

nodelay

--

true

0

false

PMID: 17456803,11777907,10770944,15498833 This phosphorylation promotes translocation of the cytosolic adaptor arrestin proteins to the membrane, where they bind to the receptor and promote internalization through interaction with Beta2-adaptin and clathrin components of the endocytic machinery

Go back
297.0, 1133.0
21.0, 21.0

p90

p90

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e99 e41

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1
stoichiometry:c249 : 1

m100*m41*0.1

nodelay

--

true

0

false

PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages

Go back
325.0, 1193.0
21.0, 21.0

p90

p91

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e100 e41

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c251 : 1
stoichiometry:c252 : 1

m101*m41*0.1

nodelay

--

true

0

false

PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages

Go back
729.0, 769.0
21.0, 21.0

p90

p92

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010514 e99

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c254 : 1
stoichiometry:c255 : 1

m93479*m100*0.1

nodelay

--

true

0

false

PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages

Go back
669.0, 781.0
21.0, 21.0

p90

p93

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010514 e100

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c258 : 1
stoichiometry:c257 : 1

m93479*m101*0.1

nodelay

--

true

0

false

PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages

Go back
342.0, 834.0
19.0, 19.0

p94

p94

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e102 e39

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c261 : 1
stoichiometry:c260 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 17456803,7836930,11301049 In fact, the effects are selective; PGE2 inhibited the production of the Th1-promoting cytokine IL-12 but amplified IL-10 production from human and mouse macrophages respectively

Go back
454.0, 818.0
19.0, 19.0

p94

p95

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e39 e103

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c264 : 1
stoichiometry:c263 : 1

m39*m104*0.1

nodelay

--

true

0

false

PMID: 17456803,7836930,11301049 In fact, the effects are selective; PGE2 inhibited the production of the Th1-promoting cytokine IL-12 but amplified IL-10 production from human and mouse macrophages respectively

Go back
562.0, 766.0
19.0, 19.0

p96

p96

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e104 e39

MO000017271

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c267 : 1
stoichiometry:c266 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 17456803,11160207 Similarly, Kuroda et al. showed that pretreatment of murine splenocytes with PGE2 suppressed the protein expression of the Th1-associated chemokine IFN-inducible protein-10 and enhanced production of macrophage-derived chemokine/CCL22, a ligand for the Th2 cell-expressed chemokine receptor CCR4.

Go back
661.0, 741.0
21.0, 21.0

p97

p97

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e105 e39

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c268 : 1

m106*m39*0.1

nodelay

--

true

0

false

Go back
18.0, 670.0
19.0, 19.0

p98

p98

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019937 e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c273 : 1

m4465*m107*0.1

nodelay

--

true

0

false

PMID: 17456803,11160207 Similarly, Kuroda et al. showed that pretreatment of murine splenocytes with PGE2 suppressed the protein expression of the Th1-associated chemokine IFN-inducible protein-10 and enhanced production of macrophage-derived chemokine/CCL22, a ligand for the Th2 cell-expressed chemokine receptor CCR4.

Go back
830.0, 1882.0
19.0, 19.0

p99

p99

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000064001 e110

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c274 : 1
stoichiometry:c275 : 1
stoichiometry:c276 : 1

m38875*m111*0.1

nodelay

--

true

0

false

PMID: 17456803,12829604 In humans, EMR2 and CD97 were identified as receptors for cell surface chondroitin sulfate , suggesting that the ligand for EMR1 may be a proteoglycan.

Go back
377.0, 272.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 172.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1544.0, 612.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1372.0, 696.3148177390107

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1381.6568542494924, 690.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1031.0, 982.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1154.130993259113, 663.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1153.0, 1013.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1091.2265745174896, 924.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1023.0, 988.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1085.0, 1149.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.8323964300478, 663.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.0, 198.45021695123648

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.0, 1210.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1017.0, 1297.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
983.0, 1205.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1123.8032284501955, 925.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.0, 1248.1344347962286

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.0, 1290.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1145.3275697126921, 663.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.0, 1380.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.0, 1288.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.9273757311803, 925.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.8718326344709, 208.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 1323.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.894996663182, 806.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.0, 926.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 972.303099757215

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.4063762906391, 934.238549617608

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1225.1659646153462, 989.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1237.859276478363, 1483.4939120578706

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1230.0, 1486.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.2512470367808, 823.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.927522221977, 1470.074426088693

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 253.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.0, 1471.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1188.8252162321928, 823.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1201.6482582782332, 1573.3460914963905

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.0, 1574.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1130.7455436233884, 989.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1142.0, 1624.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.0, 1626.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
105.19606526860798, 1038.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
98.0, 1068.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
24.0, 1164.7008847747088

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
737.0, 185.4813492843222

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
78.0, 1148.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
70.0, 1153.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 1027.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
978.0, 1009.8686564876737

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.6618489266027, 811.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
806.0, 1092.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
974.0, 1089.5055054810607

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
980.2469504755443, 812.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.0, 917.9088269514548

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
886.0, 823.0630438590632

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.5320828753572, 189.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.8233965158729, 806.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
26.0, 1228.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
85.18043461149932, 1247.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
78.0, 1282.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 798.5604537350423

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.0, 781.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 791.0933136515378

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
164.0, 856.3910112491944

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.0, 820.286811015676

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 862.0485280595767

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.0, 165.8

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 1175.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
943.0, 1221.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 1192.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
164.0, 1245.5604175994501

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
899.0, 1244.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 1178.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
92.23212418775405, 1253.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
93.0, 1314.340991912837

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
56.0, 1359.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
164.0, 1100.8249732501422

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
692.0, 241.92874237332356

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.0, 1028.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1015.0, 1011.3410742851606

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
790.0, 943.6524667910993

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
903.0, 823.4781549613758

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
164.0, 949.4644675911076

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.0, 1104.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1007.0, 1149.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
164.0, 1151.383704174637

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
58.0, 1444.3000400080607

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.84017118905696, 1375.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.0, 189.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
94.0, 1429.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 1057.5894663844042

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.9079041220812, 1008.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
93.42507200901547, 963.9779700570917

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
233.77778909726223, 1086.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
156.0, 1157.8163485663674

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
70.04975772503074, 1014.234542145062

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.0, 870.0875616271396

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
786.0, 872.4

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.0, 821.4153412422081

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.0, 172.00758194198613

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.0, 1440.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
273.0, 1469.315191898443

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.0, 1436.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
285.0, 1418.1659646153462

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 1389.9921217340739

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.4284133936338, 1248.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
171.9981994274514, 1364.1697230647735

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.1456614172743, 1389.9175412797767

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
427.16838801482936, 1189.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
71.7351251354184, 1375.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.0, 289.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.2854048166537, 260.89605815944407

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.5036704692346, 1441.8574152951178

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.9483223110846, 708.9435939469676

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 1289.9850047047198

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.0, 1191.9350533174868

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.42978107985778, 989.6220839607004

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
93.96583564658322, 957.7385542983587

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
265.94236490407974, 973.9585612815268

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
581.0, 1189.3170119383153

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.0, 1108.0

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
942.0, 1172.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
875.0, 328.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 968.0

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.0, 826.3131666338396

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 1021.5348292692504

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 1041.4528848578439

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.0, 1024.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
958.0, 1008.2322070209395

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.0, 1242.0

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
882.0, 1340.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.0, 1357.262641188963

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.0, 1109.9986190397099

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
975.0, 175.81484703686218

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.4647589618188, 1014.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
92.75801943249459, 968.2812583839363

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 1109.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.1870984557311, 1366.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 1373.991939132336

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.0, 1401.9940297109454

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 1109.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.0640869902634, 1393.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.0, 1377.848164753834

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
692.0, 1141.0

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.0, 369.5777087639997

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.2780926979885, 1370.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.0, 1389.7896871479047

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
697.0, 1141.0

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.6258967582697, 1382.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
338.05305313193827, 1588.8973009438248

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
286.62866132107314, 1558.4090509434968

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
403.1189925035708, 1589.3669454838941

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
373.725971462661, 1530.0793457790558

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.3295298094711, 1141.993210250248

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
490.0, 993.158552842508

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.0, 171.34996163499264

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.914039225684, 1141.7676543333585

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
161.0, 1363.9399641987739

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
263.05458406215325, 1283.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.1185055145116, 1075.9991222295344

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
157.0, 1506.8397763305913

c244

c244

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.8834522085988, 1284.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.22219724169216, 1075.906088407196

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.0, 1161.3795279064104

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.6390399950141, 1018.0

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
92.25850881382182, 971.9830781076876

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 100.87301613956078

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 1221.4124734289492

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.36108438490567, 1018.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
91.82488438658254, 974.4836777697952

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.0, 797.9436536224789

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
161.0, 796.251213057065

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.0, 787.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.4858826399583, 809.8607984823599

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
690.0, 797.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
157.0, 808.8371542495216

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
367.9183115728807, 853.017084139092

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
237.0, 84.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
59.99695774101277, 844.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.594816089688, 701.0

c261

c261

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
384.0, 701.0

c262

c262

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
55.99650790554707, 816.2363499873561

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.1554175279993, 835.5777087639997

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
573.9114573675189, 792.9479082447644

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
65.80949648147163, 778.0

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.0, 698.0

c267

c267

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
83.99327607372074, 728.3279292748193

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 769.90870700464

c269

c269

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
167.22508784432054, 93.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.0, 693.0

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
45.0, 680.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
41.12147519731584, 695.145770236779

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
37.0, 683.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.0, 1906.4164522465671

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
841.5263297113136, 1908.9826672882557

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 1901.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
857.0, 1934.3941549121707

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.6788339812916, 1936.1039552742184

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 1926.0

c279

c279

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.0, 195.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 1911.9459451369958

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.7622948625449, 1912.0601088778621

c281

c281

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1126.0, 1905.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.25252524303124, 879.0341510232442

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
71.02837361338504, 869.0

c284

c284

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
283.5351394693915, 880.8513277099811

c285

c285

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
48.0, 874.404605138695

c286

c286

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
520.0, 345.99586949364544

c287

c287

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.0, 307.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 337.0

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.0, 224.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.0, 772.6123037659968

c290

c290

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.3937394341912, 765.0

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
52.0, 760.2159953376884

c292

c292

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
426.2176676580731, 859.7978878724236

c293

c293

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
325.433624973259, 807.9565553870916

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.66275063908915, 860.9725003349255

c295

c295

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
52.0, 852.7987273346922

c296

c296

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.9691115068547, 502.0

c297

c297

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.8394932981931, 535.5944732131918

c298

c298

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.1682730848603, 566.998230064765

c299

c299

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
440.0, 248.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.0560627139106, 235.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
44.0, 561.9670215954612

c300

c300

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
417.56486010187456, 646.9800334000122

c301

c301

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.0, 554.9995643074166

c302

c302

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.0, 550.986320122534

c303

c303

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
375.0, 584.0

c304

c304

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.9939350536706, 625.3114520150781

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.0, 414.0

c306

c306

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 478.4960910592349

c307

c307

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
44.0, 641.9657917815798

c308

c308

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
45.0, 549.8631277935089

c309

c309

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
163.0, 349.319744306791

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
46.0, 544.6684347409438

c310

c310

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
629.0545840621533, 465.0

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.0, 533.0

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.92016788892056, 712.9469044952233

c313

c313

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
92.74422491257815, 702.0

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
430.0, 448.0

c315

c315

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 680.8780181571534

c316

c316

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
92.92275190667245, 670.0

c317

c317

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 308.0

c318

c318

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
643.1808595010745, 416.0

c319

c319

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
169.49227473161196, 356.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 712.4545638004303

c320

c320

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
93.26485590246395, 701.0

c321

c321

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 716.5244311975335

c322

c322

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
685.1120869454263, 416.0

c323

c323

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
55.87337829795612, 702.0

c324

c324

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0, 667.9805444964963

c325

c325

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.0, 308.0

c326

c326

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
55.69932444281505, 653.0

c327

c327

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.7339445046937, 665.5183473879075

c328

c328

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.0, 448.0

c329

c329

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
163.0, 400.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
55.55060923188708, 652.0

c330

c330

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
666.0, 749.8709592807993

c331

c331

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.0, 632.9276429436823

c332

c332

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 448.0

c333

c333

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 655.725001625787

c334

c334

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
769.0, 416.0

c335

c335

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
743.9617709739068, 613.781154888006

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 713.6503851815155

c337

c337

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.0, 308.0

c338

c338

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
162.0, 677.2252010403547

c339

c339

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.0, 332.2371115759281

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.6845960654559, 485.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 423.5898372966445

c341

c341

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
151.0, 310.0

c342

c342

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.8437310710337, 390.78464229992005

c343

c343

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 374.0

c344

c344

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
153.0, 247.0

c345

c345

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
300.0, 310.99737144727584

c346

c346

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
315.0, 300.0

c347

c347

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.929823205461, 454.0573097607281

c348

c348

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 453.4192481745901

c349

c349

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
166.35316024014446, 408.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.7972783164867, 408.78953928575106

c350

c350

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.0, 179.0

c351

c351

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 349.69117914086183

c352

c352

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.029062765764, 347.0

c353

c353

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
798.0, 361.6699077422622

c354

c354

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
945.470983494429, 199.0

c355

c355

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 268.74559757867803

c356

c356

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.7835922744171, 314.0

c357

c357

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
798.0, 378.0

c358

c358

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 372.4772614952592

c359

c359

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.91284947309566, 262.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 421.8999121222475

c360

c360

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
914.0, 365.985538792398

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 187.0

c362

c362

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.9276429436823, 358.073534981957

c363

c363

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.9640880952242, 202.9488132492752

c364

c364

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0, 301.0

c365

c365

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.8519580318437, 1172.9545061136425

c366

c366

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.94028500029066, 1117.7611400011626

c367

c367

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
86.0, 959.0

c368

c368

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.0, 1029.0

c369

c369

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 334.7587543633655

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.2236887300145, 1345.9968720980185

c370

c370

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.5775375331502, 1339.5536798306425

c371

c371

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.0, 1338.0

c372

c372

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.0, 1486.0

c373

c373

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1037.6169552328793, 1625.4458113133098

c374

c374

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1030.0, 1625.0

c375

c375

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.3727243454704, 1636.105307670056

c376

c376

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.7392736261543, 1550.0

c377

c377

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.2501634822136, 1565.6770283510816

c378

c378

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 1486.0

c379

c379

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.48496539058948, 329.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.111348792631, 1756.6645215717128

c380

c380

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1157.0, 1754.0

c381

c381

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.0, 1141.9674039525285

c382

c382

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
649.0, 1082.1219853038187

c383

c383

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 1079.0

c384

c384

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 1141.9802323421982

c385

c385

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
693.0, 1299.0

c386

c386

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.3510251680132, 1396.0

c387

c387

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.9309958312886, 1014.0

c388

c388

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 1075.0

c389

c389

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
292.66589909037816, 314.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.0, 1426.0

c390

c390

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
749.2054274048929, 1013.0

c391

c391

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
389.0, 1417.4247690014192

c392

c392

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
825.080829579039, 830.0

c393

c393

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
825.9999196329234, 1416.0253560674037

c394

c394

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
525.0, 1429.6710411549386

c395

c395

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
524.0, 1401.8306862184963

c396

c396

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
654.3067151496019, 104.89255950359582

c397

c397

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.0, 88.0

c398

c398

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.2973495688856, 55.27851937152828

c399

c399

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.0, 101.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 457.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 108.8587085313798

c400

c400

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.0, 44.0

c401

c401

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 56.30419498979651

c402

c402

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 103.71059333839028

c403

c403

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
807.2608084334051, 46.0

c404

c404

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 84.23519241281514

c405

c405

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0, 272.0

c406

c406

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.197769023179, 493.69219158112656

c407

c407

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.0, 481.0

c408

c408

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.0, 567.2664073870042

c409

c409

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
170.99397420119755, 504.3104456000465

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.0, 272.0

c410

c410

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0, 566.0

c411

c411

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.0, 272.0

c412

c412

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.1682867325496, 484.55185378639845

c413

c413

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.0, 486.0

c414

c414

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.45237983564886, 280.0

c415

c415

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.682769814029, 263.0

c416

c416

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 366.0

c417

c417

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.342394784387, 573.886569358273

c418

c418

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 270.0

c419

c419

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
973.0, 165.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 556.0

c420

c420

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.599458978568, 591.5218515223521

c421

c421

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.0, 272.0

c422

c422

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.1675379317294, 590.0

c423

c423

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 853.88533452553

c424

c424

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 280.0

c425

c425

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 765.5665770913955

c426

c426

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
371.0, 280.0

c427

c427

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.5157624086605, 786.7410427608056

c428

c428

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.0, 721.4278135270821

c429

c429

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
995.3148177390107, 163.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.1228965159426, 709.7131906745911

c430

c430

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.3207020834016, 553.0

c431

c431

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.0, 692.0

c432

c432

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.0, 553.0

c433

c433

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.0, 741.7774802206377

c434

c434

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1050.0, 680.352465419694

c435

c435

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.4022870018616, 1487.0

c436

c436

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 1569.9909451017954

c437

c437

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.0, 1557.0

c438

c438

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 1582.0

c439

c439

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 193.468479984129

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.0, 1529.5633714201285

c440

c440

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.6885370401606, 642.6261332937449

c441

c441

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
540.1482825780635, 550.8316376552222

c442

c442

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1006.0, 492.0

c443

c443

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.1377589008832, 445.0

c444

c444

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 405.0

c445

c445

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 495.0

c446

c446

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1157.7566899106203, 410.0

c447

c447

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1156.529637420593, 475.62210289322866

c448

c448

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1064.0, 481.1244003747298

c449

c449

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.0, 468.71205595736444

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.0, 474.0

c450

c450

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1233.923239162924, 434.1055682552917

c451

c451

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1221.4747610209454, 449.60759869401704

c452

c452

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1068.0, 448.1900452488688

c453

c453

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.8193115713575, 442.0

c454

c454

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1273.0080641124455, 601.0

c455

c455

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1253.0, 562.0

c456

c456

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1071.0, 630.0

c457

c457

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.4799802105422, 632.8372338729644

c458

c458

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1193.8924099364867, 727.3076182143292

c459

c459

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
252.53038370922653, 164.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1184.0803945819853, 562.0

c460

c460

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1071.0, 640.0

c461

c461

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.324058133142, 646.993433950834

c462

c462

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.0, 935.0

c463

c463

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 1048.0

c464

c464

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.0, 1058.0

c465

c465

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.5813914223052, 1158.0

c466

c466

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 1113.2790621242675

c467

c467

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.0, 751.5202481302871

c468

c468

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1069.305511630227, 649.7425936850725

c469

c469

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
164.49298826370972, 469.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.0, 740.0

c470

c470

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.0, 1597.6115561484353

c471

c471

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.0, 1590.0

c472

c472

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
857.4544374516627, 409.0

c473

c473

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
98.5183473879075, 1766.7339445046937

c474

c474

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
91.0, 1741.5298221281348

c475

c475

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 1640.3830729197562

c476

c476

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.35623543688007, 584.0

c477

c477

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.0, 644.0

c478

c478

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 1641.2955084488347

c479

c479

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
163.0, 508.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 481.6138580965217

c480

c480

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.78365893694018, 414.0

c481

c481

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.0, 1426.8755753318028

c482

c482

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 409.0

c483

c483

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1030.9885907180521, 1421.0

c484

c484

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.8320715579523, 1782.1620665812814

c485

c485

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
982.1849490362268, 1714.0

c486

c486

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.6257316546618, 1782.0

c487

c487

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1205.0, 333.9697873687273

c488

c488

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 319.3040606275853

c489

c489

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.32964181888235, 160.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1191.3360815775754, 324.0

c490

c490

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 769.4155745057852

c491

c491

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.0, 339.0

c492

c492

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1082.0, 704.6499055497528

c493

c493

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.0, 409.0

c494

c494

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1031.4310835055999, 821.0

c495

c495

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.0, 916.3591879744757

c496

c496

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
84.0, 970.0

c497

c497

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
302.0, 485.0

c498

c498

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
405.0, 424.9853479730495

c499

c499

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
309.0, 84.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.20441309091663, 553.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.6816936459442, 339.0

c500

c500

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
85.0, 604.7818669854026

c501

c501

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 484.0

c502

c502

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 424.8521510555045

c503

c503

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.7427469462648, 403.0

c504

c504

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
473.0, 1210.0

c505

c505

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.0402649471412, 1242.2454932435699

c506

c506

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.68392443075487, 1238.0

c507

c507

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.7853094656867, 409.0

c508

c508

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
275.0, 1860.0

c509

c509

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0, 165.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 1875.0

c510

c510

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
331.30551163022704, 1889.7425936850725

c511

c511

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 1831.0

c512

c512

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.06215041882723, 1775.220185082879

c513

c513

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 1706.0

c514

c514

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
377.87171918003884, 1691.426897736563

c515

c515

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
370.0, 1689.0

c516

c516

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.27569820671823, 1738.9952479948288

c517

c517

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 1731.0

c518

c518

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
167.0, 1606.0

c519

c519

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1068.1591724646996, 169.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
372.0, 1761.0

c520

c520

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.485433827199, 1795.6839244307548

c521

c521

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.0, 1787.0

c522

c522

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 1625.295968056471

c523

c523

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
167.0, 1593.0

c524

c524

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.8726280549289, 339.0

c525

c525

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.4376015698018, 1618.0

c526

c526

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 1706.0

c527

c527

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
390.0, 1665.9640810415613

c528

c528

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
426.54734297082234, 339.0

c529

c529

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.0, 222.04474100075572

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
267.0, 1664.347228954866

c530

c530

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.3899369085731, 1653.0

c531

c531

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.0, 1751.537342864038

c532

c532

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
167.0, 1595.0

c533

c533

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
813.6603890011434, 409.0

c534

c534

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 1753.0

c535

c535

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.96596269870486, 1798.0

c536

c536

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
275.0, 1790.0868747479792

c537

c537

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 1797.658327404353

c538

c538

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.9407947482894, 409.0

c539

c539

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.4491948298336, 196.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 1789.0

c540

c540

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.9602975216799, 401.796029752168

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
974.9922778767136, 172.93822301370935

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1083.7163950920267, 219.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.3531602401445, 336.15135438863337

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.7263945889712, 172.52108852129987

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
373.0, 90.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.8433313078928, 165.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 456.30167207920204

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
167.0, 593.8374782761443

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.0, 603.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 554.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
229.13549443922156, 590.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
70.0, 777.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
111.08994584389369, 770.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
105.0, 804.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
64.0, 778.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 194.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
108.22990271114831, 859.4246907579123

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
98.0, 861.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 828.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.0, 962.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 826.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.0, 906.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 755.3161403852198

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
286.0, 746.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 695.3493530749837

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.0, 681.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.0, 228.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
162.0, 835.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
71.97169972720937, 994.6723120251863

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.3104923889621, 1023.2491077284276

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
353.735202866793, 961.0412340898481

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
94.0, 956.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1462.570370757998, 477.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1377.0, 646.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1382.196065268608, 661.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1485.0, 740.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1377.0, 656.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.0, 171.25708160345943

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1380.8021211735029, 746.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1373.0, 912.4376995736171

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1464.50278752799, 748.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1381.8428768595913, 918.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1077.0, 708.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1248.5354166235045, 969.6865398396842

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1241.0, 971.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1377.0, 509.0022879028458

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1544.0, 512.9924492668405

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1383.0, 496.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back