1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17502339.csml convertedTime:2009.07.01.11:04

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways inmacrophage activation.
Authors Hu X, Chen J, Wang L, Ivashkiv LB.
Affiliation Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, NewYork, New York 10021, USA.
Abstract Macrophage phenotype and activation are regulated by cytokines that use theJak-STAT signaling pathway, microbial recognition receptors that include TLRs,and immunoreceptors that signal via ITAM motifs. The amplitude and qualitativenature of macrophage activation are determined by crosstalk among thesesignaling pathways. Basal ITAM signaling restrains macrophage responses to TLRsand other activating ligands, whereas strong ITAM signals synergize with thesame ligands to activate cells strongly. Similarly, basal ITAM signalingaugments IFN signaling and function of receptor activator of NF-kappaB, butextensive ITAM activation inhibits Jak-STAT signaling. Thus, intensity andduration of ITAM signaling determine whether ITAM-coupled receptors augment orattenuate TLR and Jak-STAT responses. IFN-gamma synergizes with TLRs in part bysuppressing TLR-induced feedback inhibition, mediated by IL-10 and Stat3, by amechanism that depends on glycogen synthase kinase (GSK)3 regulation of AP-1 andCREB. IFN-gamma suppresses TLR2 and TLR4 induction/activation of AP-1 byoverlapping mechanisms that include regulation of MAPKs, GSK3-dependentsuppression of DNA binding, and decreased Fos and Jun protein expression andstability. IFN-gamma suppression of TLR-induced activation of AP-1 anddownstream target genes challenges current concepts about the inflammatory roleof AP-1 proteins in macrophage activation and is consistent with a role for AP-1in the generation of noninflammatory osteoclasts. Jak-STAT, TLR, and ITAMpathways are basally active in macrophages and strongly induced during innateresponses. Thus, signal transduction crosstalk is regulated in a dynamic manner,which differs under homeostatic and pathologic conditions, and dysregulation ofsignal transduction crosstalk may contribute to pathogenesis of chronicinflammatory diseases.
PMID 17502339
Model Abstract

Entity

G010214:c-fos G010232:c-jun G010329:TNF-alpha G010345:PAI-2 G011345:IL10 G012252:CXCL10 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000048:AKT MO000000058:NF-kappaB MO000000077:MAPKs{active} MO000000102:PLCgamma{active} MO000000104:PKC{active} MO000000136:Src family MO000000276:AP-1 MO000000279:c-Fos MO000000289:TNF-alpha MO000007384:IL-6 MO000007937:CaMKII MO000008301:Syk MO000013119:STAT1 MO000013122:STAT3 MO000016882:LPS MO000017189:CREB MO000017247:IL-10 MO000018210:FcRgamma MO000019394:TLR4 MO000019397:TLR2 MO000019704:STAT1{p} MO000038698:CREB{pS} e1: e10: e11:TLR ligand e12:NF-kappaB{active} e13:IRFs e14:IRFs{active} e15:ERK{active} e16:JNK{active} e17:p38{active} e18:NF-kappaB{active} e19:inflammatory genes e2: e20:type I IFN e21:type I IFN e22:AP-1{p} e23:MMP e24:MMP e25:IL-12 e26:Ets e27:Ets{active} e28:CREB/activatingfactor e29:CREB/activatingfactor{act} e3: e30:DNA:histone e31:DNA:histone{p} e32:IFN-gammaR:JAK e33:IFN-gamma e34:IFN-gamma:IFN-gammaR:JAK e35:IFN-gamma:IFN-gammaR:JAK{act} e36:(stat1{p})2 e37:(stat1{p})2 e38:DNA e39:DNA:(stat1{p})2 e4: e40:TLR e41:FcgammaRI e42:STAT3{active} e43:STAT1{active} e44:IFN-alpha e45:DAP12 e46:CXCL9 e47:TREM2 ligand e48:TREM2 ligand:TREM2 e49:TREM2:DAP12 e5:TLR ligand:TLR e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR e60: e61: e62: e63:SIRPbeta1:DAP12 e64:SIRPbeta1:DAP12:ligand e65:e65 e66:NFATc1 e67:NFATc1 e68:NFATc1{active} e69:Semaphorin 6D e7: e70:plexin A1-TREM2-DAP12 e71:plexin A1-TREM2-DAP12-Semaphorin 6D e72:LPS:TLR4 e73:MAPKs e74:TLR2 ligand:TLR2 e75:TLR2 ligand e76:AKT{active} e77:GSK-3beta e78:gsk-3beta{p} e79:DNA e8: e80:DNA:AP1 e81:MMP1 e82:ITAM receptor lgand: ITAM receptor e83:ITAM receptor e84:ITAM receptor ligand e85:ITAM e86:ITAM receptor lgand: ITAM receptor:ITAM e87:ITAM receptor lgand: ITAM receptor:ITAM{p} e88:ITAM receptor lgand: ITAM receptor:ITAM{p}:syk e89:PTK e9: e90:PTK{active} e91:PKC e92:ca2+ e93:PLCgamma

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p9
Model Detail
810.0, 1469.5
36.5, 36.5

c-fos

--

G010214

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p14 p15 p16 p69

--

true true true true

csml-variable:Double

m93203

10

false

infinite

0

unit false false false
TRANSFACG010214

--

Go back
545.0, 1341.0
30.0, 30.0

c-jun

--

G010232

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p17 p18 p19 p68

--

true true true true

csml-variable:Double

m93221

10

false

infinite

0

unit false false false
TRANSFACG010232

--

Go back
910.0, 1262.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21

p31 p32 p33

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
481.0, 1421.0
22.0, 22.0

PAI-2

--

G010345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p78

--

true true true true

csml-variable:Double

m93323

10

false

infinite

0

unit false false false
TRANSFACG010345

--

Go back
1044.0, 1420.0
24.0, 24.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p71

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
565.0, 1573.0
22.0, 22.0

CXCL10

--

G012252

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p55

--

true true true true

csml-variable:Double

m95041

10

false

infinite

0

unit false false false
TRANSFACG012252

--

Go back
696.0, 672.0
24.0, 24.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
359.0, 439.0
26.0, 26.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
565.0, 573.0
38.0, 38.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1047.0, 683.0
26.0, 26.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1269.0, 804.5
22.5, 22.5

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p47 p84

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1006.0, 222.0
28.0, 28.0

MAPKs{active}

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

p67 p72 p85

p42 p73

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1154.0, 1462.0
36.0, 36.0

PLCgamma{active}

--

MO000000102

cso30:c:Protein

cso30:i:CC_CellComponent

--

p87

p88

true true true true

csml-variable:Double

m100

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
990.0, 302.0
28.0, 28.0

PKC{active}

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

p86

p43

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
1177.0, 1597.0
30.0, 30.0

Src family

--

MO000000136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p81

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
TRANSPATHMO000000136

--

Go back
371.0, 935.0
26.0, 26.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12 p13

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
314.0, 1446.0
36.0, 36.0

c-Fos

--

MO000000279

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m221

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
1290.0, 1282.0
28.0, 28.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31 p32 p33

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
416.0, 52.0
32.0, 32.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p51

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
718.0, 378.0
28.0, 28.0

CaMKII

--

MO000007937

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m1023

10

false

infinite

0

unit false false false
TRANSPATHMO000007937

--

Go back
803.0, 423.0
26.0, 26.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p82

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
702.0, 266.0
28.0, 28.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p42 p43 p44 p51 p52 p53 p54

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
319.0, 211.0
26.0, 26.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p49 p50

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
1620.0, 580.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1206.0, 578.0
28.0, 28.0

CREB

--

MO000017189

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m2057

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
56.0, 276.0
32.0, 32.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
460.0, 312.0
24.0, 24.0

FcRgamma

--

MO000018210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m2891

10

false

infinite

0

unit false false false
TRANSPATHMO000018210

--

Go back
1365.0, 513.0
38.0, 38.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1359.0, 723.0
42.0, 42.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
941.0, 261.0
30.0, 30.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38 p42 p43 p44 p54

p39

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
1157.0, 709.0
30.0, 30.0

CREB{pS}

--

MO000038698

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m16884

10

false

infinite

0

unit false false false
TRANSPATHMO000038698

--

Go back
179.82085777245734, 125.42090153811476
1251.9816835583956, 1779.1169616388793

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
191.8836141209222, 152.61388048650048
1213.5536413131651, 1670.729660229074

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1592.0, 312.4279437609842
47.80316344463972, 31.072056239015822

TLR ligand

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1109.0, 905.0
30.0, 30.0

NF-kappaB{active}

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2 p47 p84

p7

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
879.0, 636.6473339569692
16.186155285313372, 37.35266604303085

IRFs

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
923.0, 784.7745556594949
17.864359214218897, 41.22544434050514

IRFs{active}

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p3

p9

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
696.0, 860.0
24.0, 24.0

ERK{active}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p11 p14 p19 p25 p28 p31 p20

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
505.0, 709.0
38.0, 38.0

JNK{active}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p12 p15 p18 p26 p29 p33 p34

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
359.0, 627.0
26.0, 26.0

p38{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p13 p16 p17 p27 p30 p32 p35

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
969.0, 1241.0
30.0, 30.0

NF-kappaB{active}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p8

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
960.0, 1387.5882352941178
47.64705882352941, 25.41176470588235

inflammatory genes

--

e19

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p8

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
179.82085777245734, 125.42090153811476
1251.9816835583956, 1779.1169616388793

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
719.0, 1264.522491349481
42.14532871972318, 22.47750865051903

type I IFN

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p9

p10

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
76.0, 1128.3799999999999
32.16, 24.12

type I IFN

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p49 p52

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
603.0, 934.1951219512196
34.75609756097561, 27.804878048780484

AP-1{p}

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11 p12 p13

p21 p22 p23 p76

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
848.0, 1333.8512110726645
39.65397923875433, 21.148788927335644

MMP

--

e23

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1283.0, 1194.315247895229
18.496725912067355, 42.68475210477082

MMP

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
487.0, 1524.4671280276818
42.24913494809688, 22.53287197231834

IL-12

--

e25

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
980.5, 881.7029583417187
22.383175689273493, 36.297041658281344

Ets

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p25 p26 p27

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
979.5, 1035.1869591467096
25.16804185952908, 40.8130408532904

Ets{active}

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

p25 p26 p27

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1236.0, 959.4362044676997
40.643992755081506, 25.063795532300258

CREB/activatingfactor

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28 p29 p30

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1246.0, 1122.2166431877642
32.89192996578788, 20.283356812235862

CREB/activatingfactor{act}

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p28 p29 p30

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
204.8604914436252, 149.9266448113776
1201.9024162160601, 1730.1054750923538

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
694.0, 1547.5
60.0, 17.0

DNA:histone

--

e30

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p20 p34 p35

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
962.0, 1547.5
60.0, 17.0

DNA:histone{p}

--

e31

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p20 p34 p35

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1048.5, 136.9165139143476
31.91818030328278, 39.08348608565239

IFN-gammaR:JAK

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1134.0, 42.466608084358526
43.12829525483304, 28.03339191564147

IFN-gamma

--

e33

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36 p48 p71 p72 p73 p74 p75 p76 p77 p78

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
915.5, 137.92732611488344
25.852082951000185, 36.07267388511654

IFN-gamma:IFN-gammaR:JAK

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
803.5, 141.92732611488344
25.852082951000185, 36.07267388511654

IFN-gamma:IFN-gammaR:JAK{act}

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38 p45 p46 p47

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
941.0, 415.0220994475138
30.580110497237566, 33.97790055248618

(stat1{p})2

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
889.0, 1431.022099447514
30.580110497237566, 33.97790055248618

(stat1{p})2

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41 p55 p56

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
882.0, 1505.5
60.0, 13.0

DNA

--

e38

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p41

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1026.0, 1487.5
60.0, 17.0

DNA:(stat1{p})2

--

e39

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p41

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
251.18381373528587, 192.8116955395871
1109.2557716327385, 1644.3353736359343

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
668.0, 1459.0588235294117
31.764705882352935, 16.941176470588236

TLR

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
588.0, 1449.2145328719726
40.84775086505191, 21.785467128027683

FcgammaRI

--

e41

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
323.0, 347.0
26.0, 26.0

STAT3{active}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48 p49 p50

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
522.0, 266.0
28.0, 28.0

STAT1{active}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51 p52 p53

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
55.0, 362.40333919156416
41.6871704745167, 27.09666080843585

IFN-alpha

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p53

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
676.0, 438.78
24.959999999999997, 18.720000000000006

DAP12

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
625.0, 1629.9031141868513
37.681660899653984, 20.096885813148788

CXCL9

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p56

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
8.0, 1243.0940246045693
39.08611599297013, 25.40597539543058

TREM2 ligand

--

e47

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p57

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
224.5, 1277.588686691515
22.945845209383904, 44.411313308484985

TREM2 ligand:TREM2

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p59 p61 p63

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
217.5, 1186.3344442592902
21.77687052157974, 26.665555740709884

TREM2:DAP12

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p57

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1367.5, 351.74764306073223
25.44705108528831, 49.252356939267706

TLR ligand:TLR

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2 p3 p4 p5 p6 p7

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
444.8359593675212, 1151.4355098866054
680.8513151291484, 604.2920277585524

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
518.372972919645, 1165.7563524420575
398.1141768166715, 585.6793369651675

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
453.7111161755363, 1159.5010092304046
663.1010015131187, 588.1610290709519

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
454.97899571953843, 1160.7418552832976
660.5652424251142, 585.6793369651675

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
444.8359593675212, 1151.4355098866054
680.8513151291484, 604.2920277585524

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
444.8359593675212, 1151.4355098866054
680.8513151291484, 604.2920277585524

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
454.97899571953843, 1160.7418552832976
660.5652424251142, 585.6793369651675

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
941.8447406163583, 1399.6047204650672
42.5358492289445, 37.68511652287514

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
830.2713407441706, 1573.3231678699894
120.4485566802031, 106.71276054873819

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
444.8359593675212, 1151.4355098866054
680.8513151291484, 604.2920277585524

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1364.5, 244.44288224956063
30.912126537785586, 47.55711775043937

TLR

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
605.3087834567975, 1419.9778937163753
21.561560744219054, 10.160139969977912

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
604.5887819117911, 1389.6779520419288
73.80015836314328, 130.00788927756534

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
635.5488483470615, 1474.2359288078258
11.52002472010041, 11.274396902119483

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
218.5, 1367.5154140976504
26.52907848691885, 32.48458590234961

SIRPbeta1:DAP12

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p58

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
227.5, 1460.0366147774612
24.264415698311772, 46.96338522253892

SIRPbeta1:DAP12:ligand

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p58

p60 p62 p64

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
17.0, 1412.304920913884
37.2231985940246, 24.195079086115992

e65

--

e65

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
717.0, 1693.7370242214533
37.99307958477508, 20.262975778546714

NFATc1

--

e66

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p59 p60

p61 p62

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
315.0, 1626.3713751169319
18.472404115996255, 42.628624883068284

NFATc1

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p61 p62

p63 p64

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
315.0, 1745.307764265669
17.633302151543493, 40.69223573433115

NFATc1{active}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p63 p64

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
26.0, 809.3699472759226
44.81546572934975, 29.130052724077334

Semaphorin 6D

--

e69

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p65

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
196.27007097490952, 132.58020883664167
1227.8039783416664, 1702.6715455762974

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
218.5, 805.7711506698477
26.68067535327583, 37.228849330152315

plexin A1-TREM2-DAP12

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p65

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
222.0, 869.5588235294117
27.264705882352942, 45.44117647058824

plexin A1-TREM2-DAP12-Semaphorin 6D

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1374.5, 604.6794562595923
19.798947599210702, 38.32054374040781

LPS:TLR4

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p66

p67 p68 p69

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1162.0, 230.0
28.0, 28.0

MAPKs

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67 p72 p85

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1369.5, 804.5744354308266
20.36987502740627, 39.425564569173424

TLR2 ligand:TLR2

--

e74

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p70

p71 p72 p74 p77 p78

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1581.0, 751.4595782073814
38.5237258347979, 25.040421792618627

TLR2 ligand

--

e75

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p70

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1027.0, 807.0
26.0, 26.0

AKT{active}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

p75

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
703.0, 511.2969410344133
42.49144697122158, 26.20305896558664

GSK-3beta

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p75

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
776.0, 667.3414634146342
32.07317073170731, 25.658536585365848

gsk-3beta{p}

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

p75

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
858.0, 1641.5
60.0, 13.0

DNA

--

e79

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p76

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
200.6565278288968, 162.63071631142998
1177.8469866534253, 1673.768538062333

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
998.0, 1603.5
60.0, 17.0

DNA:AP1

--

e80

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p76

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
888.0, 1689.325259515571
40.6401384083045, 21.674740484429066

MMP1

--

e81

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1372.5, 1450.9831177373385
22.225389169041875, 43.01688226266169

ITAM receptor lgand: ITAM receptor

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p79

p80

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1372.5, 1361.304042179262
23.85237258347979, 36.69595782073814

ITAM receptor

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p79

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1580.0, 1423.7583479789103
24.21792618629174, 15.741652021089632

ITAM receptor ligand

--

e84

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p79

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1282.0, 1506.98
35.36, 26.520000000000003

ITAM

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p80

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1370.5, 1561.6300238575886
26.065149568728206, 36.36997614241145

ITAM receptor lgand: ITAM receptor:ITAM

--

e86

cso30:c:Complex

cso30:i:CC_Extracellular

--

p80

p81

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1373.5, 1644.8623600660674
21.59864195265186, 30.137639933932835

ITAM receptor lgand: ITAM receptor:ITAM{p}

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p81

p82

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1369.0, 1709.6764705882351
21.794117647058826, 36.3235294117647

ITAM receptor lgand: ITAM receptor:ITAM{p}:syk

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p82

p83 p84 p85 p86 p87

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1076.0, 1728.2850674179915
39.26745824109479, 24.21493258200845

PTK

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p83

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
212.35374610619598, 192.68122378621817
1172.4694690697704, 1651.8174830940925

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1243.0, 1767.4682028577179
42.21372509559267, 26.03179714228215

PTK{active}

--

e90

cso30:c:Protein

cso30:i:CC_Cytosol

--

p83

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
998.0, 406.0
28.0, 28.0

PKC

--

e91

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m98

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
1177.5, 1357.3430306453893
28.179353198700753, 28.656969354610936

ca2+

--

e92

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p88

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1122.0, 1586.0
36.0, 36.0

PLCgamma

--

e93

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87

true true true true

csml-variable:Double

m101

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
1483.0, 319.5
17.5, 17.5

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e11

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m11*0.1

nodelay

--

true

0

false

--

Go back
568.0, 1128.0
23.0, 23.0

p10

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 17502339 IRFs are induced or activated by TLR ligation and are particularly important in driving Type I IFN production and downstream activation of IFN-inducible genes.

Go back
474.0, 938.0
19.0, 19.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000276 e15

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m219*m17*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
518.0, 986.0
19.0, 19.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000276 e16

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m219*m18*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
461.0, 869.0
21.0, 21.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000276 e17

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m219*m19*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
816.0, 1320.0
23.0, 23.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G010214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c37 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
750.0, 1342.0
19.0, 19.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e16

G010214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
690.0, 1346.0
19.0, 19.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G010214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
509.0, 1329.0
21.0, 21.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G010232

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c45 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
534.0, 1290.0
19.0, 19.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e16

G010232

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c44 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
563.0, 1266.5
18.5, 18.5

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G010232

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c43 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 17502339 MAPKs induce the expression of AP-1 family transcription factors such as Fos and Jun and activate the transcriptional activity of AP-1 proteins by phosphorylation of their transcription activation domains.

Go back
1214.0, 846.0
19.0, 19.0

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e5

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c14 : 1
stoichiometry:c5 : 1

m12*m5*0.1

nodelay

--

true

0

false

PMID: 17502339 TLR signaling results in the downstream activation of three major families of proteins important in activating inflammatory gene expression: NF-{kappa}B/Rel proteins; IRFs; and MAPKs¡½the ERKs and the stress kinases JNK and p38.

Go back
849.0, 1545.0
21.0, 21.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e30 e15

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c87 : 1
stoichiometry:c86 : 1

m34*m17*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
912.0, 1192.0
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e22

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c49 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 17502339 AP-1 proteins have been implicated in invasive cell growth and matrix metalloprotease (MMP) production and in cell line models, have been suggested to mediate induction of inflammatory genes such as TNF-{alpha}.

Go back
856.0, 1204.0
23.0, 23.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 17502339 AP-1 proteins have been implicated in invasive cell growth and matrix metalloprotease (MMP) production and in cell line models, have been suggested to mediate induction of inflammatory genes such as TNF-{alpha}.

Go back
1228.0, 1204.0
23.0, 23.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e23 e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m27*m26*0.1

nodelay

--

true

0

false

PMID: 17502339 AP-1 proteins have been implicated in invasive cell growth and matrix metalloprotease (MMP) production and in cell line models, have been suggested to mediate induction of inflammatory genes such as TNF-{alpha}.

Go back
495.0, 1451.0
25.0, 25.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000279

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17502339, 15067049, 15123779 Fos actually suppresses the expression of IL-12.

Go back
895.0, 963.0
17.0, 17.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e15

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c64 : 1
stoichiometry:c59 : 1

m30*m17*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
983.0, 967.0
17.0, 17.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e16

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c65 : 1
stoichiometry:c61 : 1

m30*m18*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
1030.0, 966.0
19.0, 19.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e17

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c66 : 1
stoichiometry:c63 : 1

m30*m19*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
1168.0, 1056.0
15.0, 15.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e15

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c73 : 1
stoichiometry:c68 : 1

m32*m17*0.1

nodelay

--

true

0

false

--

Go back
1238.0, 1050.0
19.0, 19.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e16

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c74 : 1
stoichiometry:c70 : 1

m32*m18*0.1

nodelay

--

true

0

false

--

Go back
918.0, 698.0
19.0, 19.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 e5

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c15 : 1
stoichiometry:c7 : 1

m14*m5*0.1

nodelay

--

true

0

false

PMID: 17502339 TLR signaling results in the downstream activation of three major families of proteins important in activating inflammatory gene expression: NF-{kappa}B/Rel proteins; IRFs; and MAPKs¡½the ERKs and the stress kinases JNK and p38.

Go back
1302.0, 1042.0
19.0, 19.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e17

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c75 : 1
stoichiometry:c72 : 1

m32*m19*0.1

nodelay

--

true

0

false

--

Go back
1158.0, 1206.0
19.0, 19.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e15

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c82 : 1
stoichiometry:c79 : 1

m93309*m17*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
1166.0, 1322.0
19.0, 19.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e17

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c84 : 1
stoichiometry:c81 : 1

m93309*m19*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
1190.0, 1278.0
19.0, 19.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e16

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c83 : 1
stoichiometry:c80 : 1

m93309*m18*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
811.0, 1603.0
17.0, 17.0

p34

p34

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e30 e16

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c89 : 1

m34*m18*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
802.0, 1650.0
19.0, 19.0

p35

p35

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e30 e17

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m34*m19*0.1

nodelay

--

true

0

false

PMID: 17502339, 11743587 MAPKs can activate Ets and CREB/activating transcription factor, stabilize mRNAs, which encode inflammatory cytokines, induce efficient translation of TNF-{alpha} mRNA, and lead to phosphorylation of histones at inflammatory gene loci

Go back
983.0, 63.0
17.0, 17.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e33 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m37*m36*0.1

nodelay

--

true

0

false

PMID: 17502339 Binding of IFN-{gamma} to its cell surface receptor leads to the activation of receptor-associated Jak protein tyrosine kinases, followed by tyrosine phosphorylation and activation of latent cytoplasmic proteins¡½STATs¡½which in turn, dimerize and translocate to the nucleus, where they bind to promoter sequences and activate transcription.

Go back
848.0, 56.0
15.0, 15.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 17502339 Binding of IFN- to its cell surface receptor leads to the activation of receptor-associated Jak protein tyrosine kinases, followed by tyrosine phosphorylation and activation of latent cytoplasmic proteins¡½STATs¡½which in turn, dimerize and translocate to the nucleus, where they bind to promoter sequences and activate transcription.

Go back
821.0, 233.0
21.0, 21.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e35

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m1357*m39*0.1

nodelay

--

true

0

false

PMID: 17502339 Binding of IFN-gamma to its cell surface receptor leads to the activation of receptor-associated Jak protein tyrosine kinases, followed by tyrosine phosphorylation and activation of latent cytoplasmic proteins¡½STATs¡½which in turn, dimerize and translocate to the nucleus, where they bind to promoter sequences and activate transcription. PMID: 17502339 IFN-{gamma} activates Stat1 predominantly, which mediates the activating functions of IFN-{gamma}, including enhanced microbial killing, increased antigen presentation, and enhanced inflammatory cytokine production.

Go back
946.0, 358.0
19.0, 19.0

p39

p39

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000019704

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 17502339 Binding of IFN-gamma to its cell surface receptor leads to the activation of receptor-associated Jak protein tyrosine kinases, followed by tyrosine phosphorylation and activation of latent cytoplasmic proteins¡½STATs¡½which in turn, dimerize and translocate to the nucleus, where they bind to promoter sequences and activate transcription.

Go back
697.0, 781.0
21.0, 21.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e5

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c17 : 1
stoichiometry:c9 : 1

m16*m5*0.1

nodelay

--

true

0

false

PMID: 17502339 TLR signaling results in the downstream activation of three major families of proteins important in activating inflammatory gene expression: NF-{kappa}B/Rel proteins; IRFs; and MAPKs¡½the ERKs and the stress kinases JNK and p38.

Go back
825.0, 525.0
21.0, 21.0

p40

p40

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17502339 Binding of IFN- to its cell surface receptor leads to the activation of receptor-associated Jak protein tyrosine kinases, followed by tyrosine phosphorylation and activation of latent cytoplasmic proteins¡½STATs¡½which in turn, dimerize and translocate to the nucleus, where they bind to promoter sequences and activate transcription.

Go back
972.0, 1488.0
15.0, 15.0

p41

p41

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e38 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m42*m41*0.1

nodelay

--

true

0

false

PMID: 17502339 Binding of IFN- to its cell surface receptor leads to the activation of receptor-associated Jak protein tyrosine kinases, followed by tyrosine phosphorylation and activation of latent cytoplasmic proteins¡½STATs¡½which in turn, dimerize and translocate to the nucleus, where they bind to promoter sequences and activate transcription.

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820.0, 264.0
23.0, 23.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 MO000000077

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c110 : 1

m1357*m69*0.1

nodelay

--

true

0

false

PMID: 17502339 STAT transcriptional activity is potentiated by serine phosphorylation of transcription activation domains, which can be mediated by multiple kinases, including MAPKs, PKC, and calmodulin-dependent protein kinase II. PMID: 17502339 IFN-{gamma} activates Stat1 predominantly, which mediates the activating functions of IFN-{gamma}, including enhanced microbial killing, increased antigen presentation, and enhanced inflammatory cytokine production.

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809.0, 305.0
21.0, 21.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 MO000000104

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m1357*m92*0.1

nodelay

--

true

0

false

PMID: 17502339 STAT transcriptional activity is potentiated by serine phosphorylation of transcription activation domains, which can be mediated by multiple kinases, including MAPKs, PKC, and calmodulin-dependent protein kinase II. PMID: 17502339 IFN-{gamma} activates Stat1 predominantly, which mediates the activating functions of IFN-{gamma}, including enhanced microbial killing, increased antigen presentation, and enhanced inflammatory cytokine production.

Go back
808.0, 356.0
23.0, 23.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 MO000007937

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m1357*m1023*0.1

nodelay

--

true

0

false

PMID: 17502339 STAT transcriptional activity is potentiated by serine phosphorylation of transcription activation domains, which can be mediated by multiple kinases, including MAPKs, PKC, and calmodulin-dependent protein kinase II. PMID: 17502339 IFN-{gamma} activates Stat1 predominantly, which mediates the activating functions of IFN-{gamma}, including enhanced microbial killing, increased antigen presentation, and enhanced inflammatory cytokine production.

Go back
648.0, 1368.0
23.0, 23.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c118 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 17502339 IFN-{gamma}-induced increases in TLR and Fc{gamma}RI expression

Go back
593.0, 1377.0
21.0, 21.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c119 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 17502339 IFN-{gamma}-induced increases in TLR and Fc{gamma}RI expression

Go back
1154.0, 794.0
19.0, 19.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e35

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m12*m39*0.1

nodelay

--

true

0

false

PMID: 17502339 IFN-gamma enhanced activation of NF-{kappa}B

Go back
324.0, 280.0
23.0, 23.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017247 MO000013122 e33

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c193 : 1
stoichiometry:c127 : 1

m2103*m1360*0.1

nodelay

--

true

0

false

PMID: 17502339 Stat1, which is activated by IFN-{gamma}, and Stat3, activated by IL-10, oppose each other¡Çs activity in the regulation of inflammation PMID: 17502339, 16713974 We reported recently that IFN-{gamma} suppresses TLR-mediated induction of IL-10 expression and downstream Stat3 activation, thereby interrupting a TLR2-induced feedback inhibition loop

Go back
379.0, 279.0
17.0, 17.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013122 e21

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c130 : 1
stoichiometry:c129 : 1

m1360*m25*0.1

nodelay

--

true

0

false

PMID: 17502339, 16571725 Pleiotropic cytokines such as Type I IFNs and IL-6 activate Stat1 and Stat3, and the balance between Stat1 and Stat3 activation by these cytokines can determine the balance of their pro- and anti-inflammatory functions.

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574.0, 642.0
19.0, 19.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e5

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c16 : 1
stoichiometry:c11 : 1

m21*m5*0.1

nodelay

--

true

0

false

PMID: 17502339 TLR signaling results in the downstream activation of three major families of proteins important in activating inflammatory gene expression: NF-{kappa}B/Rel proteins; IRFs; and MAPKs¡½the ERKs and the stress kinases JNK and p38.

Go back
421.0, 269.0
21.0, 21.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013122 MO000007384

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m1360*m871*0.1

nodelay

--

true

0

false

--

Go back
618.0, 270.0
19.0, 19.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013119 MO000007384

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c136 : 1
stoichiometry:c135 : 1

m1357*m871*0.1

nodelay

--

true

0

false

PMID: 17502339, 16571725 Pleiotropic cytokines such as Type I IFNs and IL-6 activate Stat1 and Stat3, and the balance between Stat1 and Stat3 activation by these cytokines can determine the balance of their pro- and anti-inflammatory functions.

Go back
601.0, 309.0
21.0, 21.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013119 e21

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m1357*m25*0.1

nodelay

--

true

0

false

PMID: 17502339, 16571725 Pleiotropic cytokines such as Type I IFNs and IL-6 activate Stat1 and Stat3, and the balance between Stat1 and Stat3 activation by these cytokines can determine the balance of their pro- and anti-inflammatory functions.

Go back
620.0, 364.0
23.0, 23.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013119 e44 e45 MO000018210

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c141 : 1

m1357*m48*m49*m2891*0.1

nodelay

--

true

0

false

PMID: 17502339 IFN-{alpha}-induced activation of Stat1 is amplified by the ITAM-containing adapters FcR{gamma} and DAP12 and the downstream kinase Syk, which can phosphorylate Stat1 directly or could phosphorylate IFNAR Stat1-docking sites.

Go back
878.0, 374.0
19.0, 19.0

p54

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 MO000008301

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m1357*m1066*0.1

nodelay

--

true

0

false

PMID: 17502339 IFN-{alpha}-induced activation of Stat1 is amplified by the ITAM-containing adapters FcR{gamma} and DAP12 and the downstream kinase Syk, which can phosphorylate Stat1 directly or could phosphorylate IFNAR Stat1-docking sites.

Go back
561.0, 1510.0
25.0, 25.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17502339 The shift in IFN-{alpha}-induced STAT activation toward increased Stat1 activation relative to Stat2 and Stat3 activation results in enhanced expression of Stat1-dependent inflammatory genes such as the chemokines CXCL9 and CXCL10 and a shift to a more inflammatory phenotype.

Go back
633.0, 1573.0
21.0, 21.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c150 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17502339 The shift in IFN-{alpha}-induced STAT activation toward increased Stat1 activation relative to Stat2 and Stat3 activation results in enhanced expression of Stat1-dependent inflammatory genes such as the chemokines CXCL9 and CXCL10 and a shift to a more inflammatory phenotype.

Go back
101.0, 1246.0
21.0, 21.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e47 e49

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c152 : 1
stoichiometry:c154 : 1

m64*m66*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
113.0, 1413.0
21.0, 21.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e63 e65

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c157 : 1
stoichiometry:c156 : 1

m67*m70*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
721.0, 1633.0
21.0, 21.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c159 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
393.0, 540.0
19.0, 19.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e5

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c18 : 1
stoichiometry:c13 : 1

m20*m5*0.1

nodelay

--

true

0

false

PMID: 17502339 TLR signaling results in the downstream activation of three major families of proteins important in activating inflammatory gene expression: NF-{kappa}B/Rel proteins; IRFs; and MAPKs¡½the ERKs and the stress kinases JNK and p38.

Go back
653.0, 1669.0
21.0, 21.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e64

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c158 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
471.0, 1631.0
17.0, 17.0

p61

p61

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e48

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c166 : 1
stoichiometry:c164 : 1

m71*m65*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
506.0, 1722.0
19.0, 19.0

p62

p62

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e64

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c167 : 1
stoichiometry:c165 : 1

m71*m68*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
291.0, 1695.0
17.0, 17.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e67 e48

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c172 : 1
stoichiometry:c169 : 1

m72*m65*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
373.0, 1694.0
17.0, 17.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e67 e64

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c173 : 1
stoichiometry:c171 : 1

m72*m68*0.1

nodelay

--

true

0

false

PMID: 17502339 Ligation of the DAP12-associated, ITAM-coupled receptors TREM2 and SIRP¦Â1 by endogenous ligands, expressed on myeloid lineage osteoclast precursors, "costimulates" RANK signaling by regulating calcium oscillations, leading to expression and activation of NFATc1 and osteoclastogenesis

Go back
113.0, 813.0
21.0, 21.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e70 e69

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m75*m74*0.1

nodelay

--

true

0

false

PMID: 17502339, 16715077 A recent, exciting discovery identified Semaphorin 6D as an endogenous ligand for a receptor complex containing plexin A1-TREM2-DAP12

Go back
1538.0, 582.0
19.0, 19.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c177 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17502339 Consistent with intact MAPK activation, LPS-induced Fos and Jun mRNA expression was not inhibited in IFN-{gamma}-preactivated macrophages.

Go back
1074.0, 218.0
19.0, 19.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e73 e72

MO000000077

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c182 : 1
stoichiometry:c181 : 1

m78*m77*0.1

nodelay

--

true

0

false

PMID: 17502339 Consistent with intact MAPK activation, LPS-induced Fos and Jun mRNA expression was not inhibited in IFN-{gamma}-preactivated macrophages.

Go back
540.0, 1416.0
23.0, 23.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e72

G010232

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17502339 Consistent with intact MAPK activation, LPS-induced Fos and Jun mRNA expression was not inhibited in IFN-{gamma}-preactivated macrophages.

Go back
771.0, 1307.0
25.0, 25.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e72

G010214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c185 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17502339 Consistent with intact MAPK activation, LPS-induced Fos and Jun mRNA expression was not inhibited in IFN-{gamma}-preactivated macrophages.

Go back
1099.0, 1011.0
17.0, 17.0

p7

p7

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e12 e5

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m13*m5*0.1

nodelay

--

true

0

false

PMID: 17502339 NF-{kappa}B proteins are transcription factors whose nuclear translocation is triggered by TLR ligands, and NF-{kappa}B plays a key role in the transcriptional activation of multiple inflammatory genes.

Go back
1473.0, 756.0
19.0, 19.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e75

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c189 : 1
stoichiometry:c188 : 1

m3964*m80*0.1

nodelay

--

true

0

false

--

Go back
1045.0, 1353.0
21.0, 21.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e74 e33

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c190 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 17502339, 16713974 We reported recently that IFN-{gamma} suppresses TLR-mediated induction of IL-10 expression and downstream Stat3 activation, thereby interrupting a TLR2-induced feedback inhibition loop

Go back
1074.0, 258.0
19.0, 19.0

p72

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e73 e74 e33

MO000000077

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c195 : 1

m78*m79*0.1

nodelay

--

true

0

false

PMID: 17502339 The mechanism of inhibition of TLR2-induced IL-10 production involves attenuation of TLR2-induced MAPK activation, which results in diminished AP-1 (Fos and Jun) expression and diminished CREB phosphorylation on the transcription-activating site serine 13

Go back
1189.0, 645.0
21.0, 21.0

p73

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017189 MO000000077 e33

MO000038698

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c199 : 1

m2057*m69*0.1

nodelay

--

true

0

false

PMID: 17502339 The mechanism of inhibition of TLR2-induced IL-10 production involves attenuation of TLR2-induced MAPK activation, which results in diminished AP-1 (Fos and Jun) expression and diminished CREB phosphorylation on the transcription-activating site serine 13

Go back
1010.0, 750.0
19.0, 19.0

p74

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e74 e33

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c203 : 1

m81*m79*0.1

nodelay

--

true

0

false

PMID: 17502339 In addition, IFN-{gamma} suppresses TLR2-induced Akt activity, which is linked with decreased phosphorylation and increased activity of GSK3¦Â, which in turn, contributes to inhibition of AP-1 DNA binding, likely by phosphorylation of the Jun DNA-binding domain

Go back
777.0, 607.5
17.5, 17.5

p75

p75

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e77 e76 e33

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c207 : 1

m83*m82*0.1

nodelay

--

true

0

false

PMID: 17502339 In addition, IFN-{gamma} suppresses TLR2-induced Akt activity, which is linked with decreased phosphorylation and increased activity of GSK3¦Â, which in turn, contributes to inhibition of AP-1 DNA binding, likely by phosphorylation of the Jun DNA-binding domain

Go back
949.0, 1640.0
19.0, 19.0

p76

p76

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e79 e22 e33

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c211 : 1

m85*m26*0.1

nodelay

--

true

0

false

PMID: 17502339 IFN-{gamma} suppresses TLR2-induced Akt activity, linked with decreased phosphorylation and increased activity of GSK3¦Â, which in turn, contributes to inhibition of AP-1 DNA binding.

Go back
814.0, 1694.0
19.0, 19.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74 e33

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c214 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 17502339, 16713974 Diminished AP-1 and CREB activity in IFN-{gamma}-primed, TLR2-activated cells leads to decreased expression of AP-1 and CREB target genes, including MMP-1 (collagenase), plasminogen activator inhibitor-2 (PAI-2), and IL-10

Go back
490.0, 1370.0
19.0, 19.0

p78

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e74 e33

G010345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c217 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 17502339, 16713974 Diminished AP-1 and CREB activity in IFN-{gamma}-primed, TLR2-activated cells leads to decreased expression of AP-1 and CREB target genes, including MMP-1 (collagenase), plasminogen activator inhibitor-2 (PAI-2), and IL-10

Go back
1462.0, 1422.0
19.0, 19.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e84 e83

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c221 : 1
stoichiometry:c222 : 1

m90*m89*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
972.0, 1328.0
23.0, 23.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 17502339 NF-{kappa}B proteins are transcription factors whose nuclear translocation is triggered by TLR ligands, and NF-{kappa}B plays a key role in the transcriptional activation of multiple inflammatory genes.

Go back
1461.0, 1509.0
21.0, 21.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e82 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m88*m91*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1473.0, 1601.0
21.0, 21.0

p81

p81

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e86 MO000000136

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c228 : 1
stoichiometry:c227 : 1

m93*m122*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1477.0, 1694.0
17.0, 17.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e87 MO000008301

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m94*m1066*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1165.0, 1769.0
21.0, 21.0

p83

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e89 e88

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c234 : 1
stoichiometry:c233 : 1

m96*m95*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1267.0, 859.0
17.0, 17.0

p84

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000058 e88

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c237 : 1
stoichiometry:c236 : 1

m12*m95*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1071.0, 299.0
17.0, 17.0

p85

p85

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e73 e88

MO000000077

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c240 : 1
stoichiometry:c239 : 1

m78*m95*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1030.0, 354.0
19.0, 19.0

p86

p86

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e91 e88

MO000000104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c243 : 1
stoichiometry:c242 : 1

m98*m95*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1134.0, 1526.0
19.0, 19.0

p87

p87

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e93 e88

MO000000102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c246 : 1
stoichiometry:c245 : 1

m101*m95*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
1211.0, 1419.0
17.0, 17.0

p88

p88

cso30:i:ME_UnknownProduction

cso30:i:CC_Extracellular

--

MO000000102

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1

m100*0.1

nodelay

--

true

0

false

PMID: 17502339 ITAM-mediated signaling is initiated by Src family kinase phosphorylation of the two ITAM motif tyrosines, leading to the recruitment and activation of the PTK Syk and downstream signaling pathways, which include activation of PTKs, NF-{kappa}B, MAPKs, and protein kinase C (PKC) and calcium-mediated signaling pathways (via activation of phospholipase C{gamma}).

Go back
730.0, 1202.0
19.0, 19.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c24 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17502339 IRFs are induced or activated by TLR ligation and are particularly important in driving Type I IFN production and downstream activation of IFN-inducible genes.

Go back
1395.0, 276.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.0, 611.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.0, 247.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 178.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
956.0, 291.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 377.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0560172115273, 445.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.0, 546.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 1499.9402850002907

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 1458.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 1496.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 276.2665186418611

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.9656235549245, 661.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 276.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.8217163921715, 239.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.0, 285.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.0, 282.2797621446637

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
838.0, 316.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.0, 292.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.0, 290.5066945971321

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 373.11546676004895

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
663.0, 1391.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 1398.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
376.0, 465.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
663.0136135235749, 178.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
607.3610167192885, 178.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1180.9569472711262, 805.8288486740756

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1131.62816499953, 813.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 178.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
88.0, 292.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.0, 237.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 303.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.0, 237.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.69782092151024, 296.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.6625609418811, 559.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
96.0, 303.5570765377233

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.0, 231.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
355.145770236779, 289.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.0, 84.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
645.0, 280.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 280.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.0, 84.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.4595317214688, 285.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0703033307765, 290.7431017633523

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
99.0, 336.75242590449676

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1229.4784853744168, 401.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
648.2558262477422, 294.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.6568542494924, 299.65685424949237

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
97.0, 376.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
645.8776860867976, 393.3409919128368

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.0, 328.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.0, 288.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 297.7425936850725

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.0, 395.73661147168553

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
575.0, 1535.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.8003034806065, 1451.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
943.4517158329364, 385.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
644.0, 1594.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.0878326030929, 1456.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
129.1851049429758, 1205.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
47.0, 1256.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
122.0, 1260.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.51576240866055, 1389.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.0, 1429.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
54.0, 1424.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0, 1683.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.0, 1654.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.5576830474753, 380.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
252.0, 1489.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
247.0, 1308.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.7631300276024, 1643.9323074741194

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.933033489948, 1706.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.9897278628545, 1640.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.324391861868, 1655.2176519161962

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
247.0, 1316.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
252.0, 1495.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
307.1171199266936, 1669.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 1712.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.8039051934674, 384.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.0, 1657.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
338.3941549121707, 1711.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 1322.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
252.0, 1502.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
142.0, 824.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
71.0, 824.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.0, 830.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1401.8529231173486, 594.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1565.0, 592.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1403.0, 539.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.8764369507886, 378.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1100.8816940385575, 231.37072939800998

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1041.9382230137094, 229.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1095.8380741362666, 243.37126664423857

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.0, 1378.951069877389

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.7552116849392, 633.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
787.0, 1332.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.227081612176, 635.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1401.0, 749.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1396.9972311490667, 772.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1499.9979808177366, 764.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.3488305996468, 935.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.0, 1374.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1067.1199123944907, 842.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1057.3048827310727, 71.0

c192

c192

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
350.84331937316625, 62.0

c193

c193

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1100.7409381791747, 248.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1041.1554175279994, 246.57770876399965

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.7584564348697, 284.06215301640987

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1088.2952274829886, 71.0

c197

c197

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1205.3526867907, 606.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1181.089104705009, 666.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1509.0, 328.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.7232309686189, 1028.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.0, 250.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1157.0, 71.0

c201

c201

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1030.2843362028666, 709.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1023.0, 769.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.8789652943767, 763.3863282042892

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1022.7577493856099, 71.0

c205

c205

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
733.0, 537.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 625.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.228573692809, 628.0204451748074

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.2015490526588, 71.0

c209

c209

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1115.1060768582051, 401.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 1649.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.0, 1624.764705882353

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 962.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.490844692298, 71.0

c213

c213

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
833.0, 1701.435715945279

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
834.2790969063066, 841.0

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
826.7900391833343, 71.0

c216

c216

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
495.2350150421889, 1389.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.7667110441413, 831.0

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.77670510625296, 71.0

c219

c219

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
984.0, 1271.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1489.0, 1432.0

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1396.0, 1387.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1402.3014766031522, 1437.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1395.0, 1478.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1317.0, 1520.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1403.592335393595, 1527.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1397.0, 1584.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1402.1919189506982, 1617.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1207.0, 1612.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1395.0, 1665.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 1351.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.0, 449.0

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1398.7920642163135, 1705.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1115.0, 1749.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1186.0, 1780.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1193.758639652486, 1731.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1277.4990262892416, 827.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1146.565492794439, 871.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1277.9617977651287, 883.9419736249243

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1094.6287117495312, 253.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1037.1337810613895, 256.1354944392216

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0, 1221.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1083.6509137594217, 323.827801974945

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1019.0, 380.11179645141283

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.8, 336.4

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.9334534646077, 380.7628446912325

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1141.0, 1552.990498808999

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.0, 1505.1554175279994

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1159.2018798841384, 1548.053383609298

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1188.0, 1441.87842755702

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1202.490188052155, 1393.1985128575695

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.4082203964861, 824.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
597.0866716156727, 1154.191572848662

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
116.0, 1140.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.0, 948.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.0, 948.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1400.369996491291, 332.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.5744093618427, 876.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.0, 952.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 960.6636527173945

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 747.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.0, 893.8632840217354

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 885.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.0, 653.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.0, 1343.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
711.0, 884.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
764.0, 1361.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1239.4854338271991, 824.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 747.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
709.0, 1365.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.0, 653.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.26942476307, 1285.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.0, 1309.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 1345.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.5535638189224, 884.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
525.0, 747.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
375.0, 653.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
924.0, 1215.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1145.738171205292, 862.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.0, 962.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.0, 962.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
868.0, 1227.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.0, 1222.6031252245723

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1251.0, 1216.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.0, 956.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
350.0, 1464.0

c56

c56

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
508.0, 1476.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
918.2116647551209, 909.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.0, 980.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 666.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 918.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 984.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1003.0, 917.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.1159660434203, 985.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 878.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 738.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 647.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1188.220185082879, 984.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1183.0, 1069.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1249.7242859683402, 984.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.0, 717.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1250.0, 1069.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1265.0, 984.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1272.2299810393686, 1061.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 877.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 737.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 646.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
938.0, 1219.9402850002907

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
938.0, 1279.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
938.0, 1277.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.0, 1221.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.0, 696.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1209.0, 1289.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1185.0, 1302.1297852398084

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 881.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 744.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 651.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
754.0, 1556.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.0, 1556.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
711.0, 884.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
738.0, 1565.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 1567.4301882770608

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.0, 802.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 747.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
731.0, 1565.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 1568.9977796279165

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.0, 653.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1007.962616101032, 58.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.2235169765557, 86.05927969280461

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.8515934073898, 80.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.9304660932648, 77.30004000806069

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
827.0250006673954, 71.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 249.4290863355067

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back