1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17502368.csml convertedTime:2009.07.01.11:04

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Type I interferon receptors: biochemistry and biological functions.
Authors de Weerd NA, Samarajiwa SA, Hertzog PJ.
Affiliation Centre for Functional Genomics and Human Disease, Monash Institute of MedicalResearch, Monash University, Clayton, Victoria 3168, Australia.
Abstract
PMID 17502368
Model Abstract

Entity

MO000000145:Jak1 MO000000148:Tyk2 MO000007545:IFNAR1 MO000007548:IFNAR2 MO000013119:STAT1 MO000013120:STAT2 MO000016660:IFNbeta MO000017004:SOCS-1 MO000017665:ADAM17 MO000019457:IFNAR1:Tyk2 MO000042729:ADAM10 MO000066363:IFNA2 e1: e10:degradants e11:IFN-alpha e12:IFNAR2:Jak1 e13:IFN:IFNAR1{p}:Tyk2{p}:SOCS-1 e14:IFN:IFNAR2c{p}:Jak1{p}:SOCS-1 e2: e20:UBP43 e21:IFNAR1:UBP43 e23:IFNAR1:SHP e24:SHP e25:IFNAR2:UBP43 e26:IFNAR2:SHP e29:E3 ubiquitin ligase e3: e30:IFNAR1:Tyk2:E3 ubiquitin ligase e31:IFNAR1{ub}:Tyk2:E3 ubiquitin ligase e32:sIFNAR2a e33:sIFNAR2a:IFN-alpha e34:sIFNAR2a:IFNbeta e35:IFN e36:IFN:IFNAR1:Tyk2 e37:IFNAR2c:Jak1 e38:IFN:IFNAR2c:Jak1 e39:IFN:IFNAR1{p}:Tyk2{p} e4: e40:IFN:IFNAR2c{p}:Jak1{p} e41:IFN:IFNAR1{p}:Tyk2{p}:STAT1 e42:IFN:IFNAR2c{p}:Jak1{p}:STAT2 e43:IFN:IFNAR1{p}:Tyk2{p}:STAT1{p} e44:IFN:IFNAR2c{p}:Jak1{p}:STAT2{p} e45:IFN:IFNAR1{p}:Tyk2{p}:STAT1{p}(2) e46:IFN:IFNAR2c{p}:Jak1{p}:STAT2{p}(2) e47:IFN:IFNAR2c{p}:IFNAR1:Tyk2:Jak1{p}:STAT2{p}:STAT1{p} e48:STAT1{p}:STAT1{p} e49:STAT2{p}:STAT2{p} e5:IFN:IFNAR1{p}:Tyk2{p}:STAT2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFNAR2:Jak1:STAT1 e60: e61: e62: e63:STAT1{p}:STAT2{p} e64:STAT1{p}:STAT2{p} e65:STAT1{p}:STAT1{p} e66:STAT2{p}:STAT2{p} e67:IFN gene e68:STAT1{p}:STAT2{p}:IFN gene e69:STAT1{p}:STAT1{p}:IFN gene e7: e70:STAT2{p}:STAT2{p}:IFN gene e71:IFN mRNA e72:IFNA2:IFNAR1 e73:IFNA2:IFNAR2 e74:IFNAR2:IFNbeta e75:Intramembrane proteases e76:sIL-6Ralpha e77:IL-6Ralpha e8: e9:IFNAR2:Jak1:STAT1:STAT2

Process

p1 p12 p13 p14 p15 p16 p17 p19 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p6
Model Detail
568.0, 188.0
16.0, 16.0

Jak1

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
306.0, 206.0
20.0, 20.0

Tyk2

--

MO000000148

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p1

true true true true

csml-variable:Double

m132

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000148

--

Go back
278.0, 106.0
20.0, 20.0

IFNAR1

--

MO000007545

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p13 p15 p47

true true true true

csml-variable:Double

m898

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000007545

--

Go back
706.0, 110.0
20.0, 20.0

IFNAR2

--

MO000007548

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p16 p17 p48 p49 p50

true true true true

csml-variable:Double

m901

10

false

infinite

0

unit false false false
InterProIPR000282
TRANSPATHMO000007548

--

Go back
584.0, 404.0
23.0, 23.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p28

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
251.0, 239.0
25.0, 25.0

STAT2

--

MO000013120

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p6 p29

true true true true

csml-variable:Double

m1358

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013120

--

Go back
82.0, 834.0
20.0, 20.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p49

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
479.0, 383.0
18.0, 18.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p14

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
190.0, 1234.0
20.0, 20.0

ADAM17

--

MO000017665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m2428

10

false

infinite

0

unit false false false
TRANSPATHMO000017665

--

Go back
380.0, 124.0
24.0, 24.0

IFNAR1:Tyk2

--

MO000019457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p19 p24

true true true true

csml-variable:Double

m4019

10

false

infinite

0

unit false false false
TRANSPATHMO000019457

--

Go back
187.0, 1127.0
26.0, 26.0

ADAM10

--

MO000042729

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m20522

10

false

infinite

0

unit false false false
TRANSPATHMO000042729

--

Go back
354.0, 38.0
20.0, 20.0

IFNA2

--

MO000066363

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p48

true true true true

csml-variable:Double

m41221

10

false

infinite

0

unit false false false
TRANSPATHMO000066363

--

Go back
163.75, 85.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
506.0, 614.0
19.781734635267085, 19.122343480758182

degradants

--

e10

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p21

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
67.0, 484.5
25.429663916280937, 15.681626081706579

IFN-alpha

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
816.5, 114.0
22.65055824029329, 27.73537743709381

IFNAR2:Jak1

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
978.5, 174.0
18.086165314623987, 35.00548125411094

IFN:IFNAR1{p}:Tyk2{p}:SOCS-1

--

e13

cso30:c:Complex

cso30:i:CC_Extracellular

--

p12

p5 p6 p28 p29

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
978.5, 306.0
18.086165314623987, 35.00548125411094

IFN:IFNAR2c{p}:Jak1{p}:SOCS-1

--

e14

cso30:c:Complex

cso30:i:CC_Extracellular

--

p14

p5 p6 p28 p29

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
163.75, 85.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
804.0, 211.5
23.519999999999996, 17.639999999999997

UBP43

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13 p16

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
972.5, 238.0
22.59340109981669, 27.665389101816366

IFNAR1:UBP43

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
221.5, 567.0
20.42142976170638, 25.005832361273118

IFNAR1:SHP

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
525.0, 460.0
14.228250701590273, 32.834424695977546

SHP

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p17

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
976.5, 362.0
22.59340109981669, 27.665389101816366

IFNAR2:UBP43

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p4

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
973.5, 411.0
21.131811364772535, 25.875687385435757

IFNAR2:SHP

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
434.0, 547.0
11.333956969130025, 26.15528531337698

E3 ubiquitin ligase

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p21

p19

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
180.87518862352903, 103.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
183.5, 603.0
24.72361901266288, 34.49807304092494

IFNAR1:Tyk2:E3 ubiquitin ligase

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
183.5, 735.0
24.72361901266288, 34.49807304092494

IFNAR1{ub}:Tyk2:E3 ubiquitin ligase

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
86.0, 642.0
20.0, 20.0

sIFNAR2a

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p22 p23

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR000282
TRANSPATHMO000007548

--

Go back
127.5, 887.0
17.780311335233506, 34.41350581012935

sIFNAR2a:IFN-alpha

--

e33

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p22

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
131.5, 943.0
17.780311335233506, 34.41350581012935

sIFNAR2a:IFNbeta

--

e34

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p23

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
220.0, 44.5
24.428822495606344, 15.878734622144115

IFN

--

e35

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p24 p25 p50

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
182.5, 130.0
18.086165314623987, 35.00548125411094

IFN:IFNAR1:Tyk2

--

e36

cso30:c:Complex

cso30:i:CC_Extracellular

--

p24

p26

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
184.5, 202.0
22.28311948008665, 27.2854524245959

IFNAR2c:Jak1

--

e37

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p25

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
182.5, 266.0
18.086165314623987, 35.00548125411094

IFN:IFNAR2c:Jak1

--

e38

cso30:c:Complex

cso30:i:CC_Extracellular

--

p25

p27

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
626.5, 98.0
18.086165314623987, 35.00548125411094

IFN:IFNAR1{p}:Tyk2{p}

--

e39

cso30:c:Complex

cso30:i:CC_Extracellular

--

p26 p35 p36

p3 p12 p28

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
212.55678757705792, 133.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
974.5, 510.0
18.086165314623987, 35.00548125411094

IFN:IFNAR2c{p}:Jak1{p}

--

e40

cso30:c:Complex

cso30:i:CC_Extracellular

--

p27 p36 p37

p14 p29

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
974.5, 566.0
18.086165314623987, 35.00548125411094

IFN:IFNAR1{p}:Tyk2{p}:STAT1

--

e41

cso30:c:Complex

cso30:i:CC_Extracellular

--

p28

p30

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
978.5, 638.0
18.086165314623987, 35.00548125411094

IFN:IFNAR2c{p}:Jak1{p}:STAT2

--

e42

cso30:c:Complex

cso30:i:CC_Extracellular

--

p29

p31

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
974.5, 710.0
18.086165314623987, 35.00548125411094

IFN:IFNAR1{p}:Tyk2{p}:STAT1{p}

--

e43

cso30:c:Complex

cso30:i:CC_Extracellular

--

p30

p32 p34

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
974.5, 774.0
18.086165314623987, 35.00548125411094

IFN:IFNAR2c{p}:Jak1{p}:STAT2{p}

--

e44

cso30:c:Complex

cso30:i:CC_Extracellular

--

p31

p33 p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
973.5, 832.0
20.702916027187023, 40.07016005262004

IFN:IFNAR1{p}:Tyk2{p}:STAT1{p}(2)

--

e45

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p32

p35

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
981.5, 916.0
20.702916027187023, 40.07016005262004

IFN:IFNAR2c{p}:Jak1{p}:STAT2{p}(2)

--

e46

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p33

p37

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
977.5, 1004.0
20.702916027187023, 40.07016005262004

IFN:IFNAR2c{p}:IFNAR1:Tyk2:Jak1{p}:STAT2{p}:STAT1{p}

--

e47

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p34

p36

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
752.0, 821.5
32.78325618836788, 20.21634131616019

STAT1{p}:STAT1{p}

--

e48

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p35

p39

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
768.0, 957.5
32.78325618836788, 20.21634131616019

STAT2{p}:STAT2{p}

--

e49

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p37

p40

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
478.5, 82.0
18.086165314623987, 35.00548125411094

IFN:IFNAR1{p}:Tyk2{p}:STAT2

--

e5

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
299.91599085128007, 647.2579908588913
424.94933382552625, 385.3823567468001

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
345.8136842626034, 656.3909924559681
248.48061605440458, 373.51226362318215

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
305.4553676423017, 652.4016978791258
413.87058024348283, 375.0949427063308

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
306.24670718387625, 653.1930374207001
412.2879011603339, 373.51226362318215

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
299.91599085128007, 647.2579908588913
424.94933382552625, 385.3823567468001

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
299.91599085128007, 647.2579908588913
424.94933382552625, 385.3823567468001

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
306.24670718387625, 653.1930374207001
412.2879011603339, 373.51226362318215

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
610.1210911484982, 805.5258991737991
26.548499491572986, 24.033378487108237

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
540.48321148994, 916.3134349942341
75.17725644958104, 68.05520057541032

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
299.91599085128007, 647.2579908588913
424.94933382552625, 385.3823567468001

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
909.5, 101.0
21.551293815378976, 30.07157276564508

IFNAR2:Jak1:STAT1

--

e6

cso30:c:Complex

cso30:i:CC_Extracellular

--

p5

p6

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
400.07415780863295, 818.5187257565401
13.457521004797488, 6.479547150458061

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
399.62477308967186, 799.1951828412025
46.06193369353668, 82.91148064836618

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
418.94831600500964, 853.1213491165635
7.190155503381329, 7.190155503381345

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
622.5, 1172.0
18.968005332444594, 23.22612897850359

STAT1{p}:STAT2{p}

--

e63

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p36

p38

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
546.5, 964.0
18.968005332444594, 23.22612897850359

STAT1{p}:STAT2{p}

--

e64

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p38

p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
616.0, 925.5
32.78325618836788, 20.21634131616019

STAT1{p}:STAT1{p}

--

e65

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p39

p42

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
672.0, 885.5
32.78325618836788, 20.21634131616019

STAT2{p}:STAT2{p}

--

e66

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p40

p43

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
363.0, 933.5
57.13451843990448, 12.379145661979305

IFN gene

--

e67

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p41 p42 p43

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
367.0, 855.5
57.88634610439702, 16.401131396245823

STAT1{p}:STAT2{p}:IFN gene

--

e68

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p41

p44

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
483.0, 811.5
57.88634610439702, 16.401131396245823

STAT1{p}:STAT1{p}:IFN gene

--

e69

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p42

p45

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
168.0, 89.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
619.0, 787.5
57.88634610439702, 16.401131396245823

STAT2{p}:STAT2{p}:IFN gene

--

e70

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p43

p46

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
478.0, 688.0
60.0, 32.0

IFN mRNA

--

e71

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44 p45 p46

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
974.5, 454.0
18.806621354966016, 36.39991229993423

IFNA2:IFNAR1

--

e72

cso30:c:Complex

cso30:i:CC_Extracellular

--

p47

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
982.5, 89.0
19.751370313527737, 38.22845867134401

IFNA2:IFNAR2

--

e73

cso30:c:Complex

cso30:i:CC_Extracellular

--

p48

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
188.5, 990.0
22.23898267923701, 43.043192282394216

IFNAR2:IFNbeta

--

e74

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p49

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
189.5, 681.0
13.06057556852485, 21.179311732743

Intramembrane proteases

--

e75

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p50

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
68.5, 1183.0
22.27592267135325, 34.27065026362039

sIL-6Ralpha

--

e76

cso30:c:Protein

cso30:i:CC_Extracellular

--

p51 p52

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
188.5, 1067.0
22.27592267135325, 34.27065026362039

IL-6Ralpha

--

e77

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p51 p52

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
173.0, 111.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
184.0, 360.0
24.529411764705888, 40.88235294117647

IFNAR2:Jak1:STAT1:STAT2

--

e9

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
242.0, 170.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000148 MO000007545

MO000019457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m132*m898*0.1

nodelay

--

true

0

false

PMID: 17502368,8628273,16551269 IFNAR1 is preassociated with Tyk2, , which also stabilizes IFNAR1 cell surface expression levels.

Go back
526.0, 394.0
19.0, 19.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 e39

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m1906*m39*0.1

nodelay

--

true

0

false

PMID: 17502368,16311601,10022928,16710296 Thus, IFNARs also interact with a number of negative regulatory molecules, including SOCS-1 (suppressor of cytokine signaling), UBP43, and SHP , to limit the extent of signaling

Go back
482.0, 274.0
19.0, 19.0

p12

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 MO000007545

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c38 : 1
stoichiometry:c40 : 1

m20*m898*0.1

nodelay

--

true

0

false

PMID: 17502368,16311601,10022928,16710296 Thus, IFNARs also interact with a number of negative regulatory molecules, including SOCS-1 (suppressor of cytokine signaling), UBP43, and SHP , to limit the extent of signaling

Go back
506.0, 342.0
19.0, 19.0

p12

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 e40

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c37 : 1
stoichiometry:c41 : 1

m1906*m40*0.1

nodelay

--

true

0

false

PMID: 17502368,16311601,10022928,16710296 Thus, IFNARs also interact with a number of negative regulatory molecules, including SOCS-1 (suppressor of cytokine signaling), UBP43, and SHP , to limit the extent of signaling

Go back
306.0, 426.0
19.0, 19.0

p12

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007545 e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m898*m24*0.1

nodelay

--

true

0

false

PMID: 17502368,16311601,10022928,16710296 Thus, IFNARs also interact with a number of negative regulatory molecules, including SOCS-1 (suppressor of cytokine signaling), UBP43, and SHP , to limit the extent of signaling

Go back
726.0, 346.0
19.0, 19.0

p12

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007548 e20

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m901*m20*0.1

nodelay

--

true

0

false

PMID: 17502368,16311601,10022928,16710296 Thus, IFNARs also interact with a number of negative regulatory molecules, including SOCS-1 (suppressor of cytokine signaling), UBP43, and SHP , to limit the extent of signaling

Go back
690.0, 390.0
19.0, 19.0

p12

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007548 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m901*m24*0.1

nodelay

--

true

0

false

PMID: 17502368,16311601,10022928,16710296 Thus, IFNARs also interact with a number of negative regulatory molecules, including SOCS-1 (suppressor of cytokine signaling), UBP43, and SHP , to limit the extent of signaling

Go back
437.0, 501.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 MO000019457

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c15 : 1
stoichiometry:c58 : 1

m29*m4019*0.1

nodelay

--

true

0

false

PMID: 17502368,15337770 Residues within this region are also essential for the recruitment of E3 ubiquitin ligases and ubiquitination and degradation of the receptor

Go back
273.0, 645.0
21.0, 21.0

p20

p20

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17502368, 15337770 Residues within this region are also essential for the recruitment of E3 ubiquitin ligases and ubiquitination and degradation of the receptor

Go back
415.0, 611.0
25.0, 25.0

p21

p21

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e31

e10 MO000000148 e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17502368, 15337770 Residues within this region are also essential for the recruitment of E3 ubiquitin ligases and ubiquitination and degradation of the receptor

Go back
310.0, 474.0
19.0, 19.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e11 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m11*m32*0.1

nodelay

--

true

0

false

PMID: 17502368,11154225 We have demonstrated in vitro that sIFNAR2a can bind IFN{alpha} or -beta and transduce a signal through IFNAR1

Go back
286.0, 806.0
19.0, 19.0

p22

p23

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016660 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m1636*m32*0.1

nodelay

--

true

0

false

PMID: 17502368,11154225 We have demonstrated in vitro that sIFNAR2a can bind IFN{alpha} or -beta and transduce a signal through IFNAR1

Go back
134.0, 58.0
19.0, 19.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e35 MO000019457

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m35*m4019*0.1

nodelay

--

true

0

false

PMID: 17502368 Figure 1B PMID: 17502368 conventional signaling occurs when IFN binds to IFNAR1 and tmIFNAR2c resulting in cross-phosphorylation of receptors and associated Janus kinases (Tyk2 and Jak1)

Go back
110.0, 162.0
19.0, 19.0

p24

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e35 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c75 : 1
stoichiometry:c77 : 1

m35*m37*0.1

nodelay

--

true

0

false

PMID: 17502368 Figure 1B PMID: 17502368 conventional signaling occurs when IFN binds to IFNAR1 and tmIFNAR2c resulting in cross-phosphorylation of receptors and associated Janus kinases (Tyk2 and Jak1)

Go back
270.0, 426.0
19.0, 19.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e36

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17502368 Figure 1B PMID: 17502368 conventional signaling occurs when IFN binds to IFNAR1 and tmIFNAR2c resulting in cross-phosphorylation of receptors and associated Janus kinases (Tyk2 and Jak1)

Go back
602.0, 462.0
19.0, 19.0

p26

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 17502368 Figure 1B PMID: 17502368 conventional signaling occurs when IFN binds to IFNAR1 and tmIFNAR2c resulting in cross-phosphorylation of receptors and associated Janus kinases (Tyk2 and Jak1)

Go back
609.0, 553.0
21.0, 21.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e39 MO000013119 e13 e14

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c84 : 1

m39*m1357*0.1

nodelay

--

true

0

false

PMID: 17502368 This provides docking sites on the receptor complex for STAT proteins. PMID: 17502368,9121453,15864272 HuIFNAR1 also bound STAT1 and STAT2 via phospho-Tyr466 and phospho-Tyr48 when overexpressed in heterologous cells PMID: 17502368,16311601 This may occur by binding a negative regulator such as SOCS-1 to inhibit JAK/STAT signaling

Go back
597.0, 617.0
21.0, 21.0

p28

p29

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000013120 e40 e13 e14

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c87 : 1

m1358*m40*0.1

nodelay

--

true

0

false

PMID: 17502368 This provides docking sites on the receptor complex for STAT proteins. PMID: 17502368,16311601 This may occur by binding a negative regulator such as SOCS-1 to inhibit JAK/STAT signaling

Go back
410.0, 202.0
19.0, 19.0

p2

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000013120 e39

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m1358*m39*0.1

nodelay

--

true

0

false

PMID: 17502368,9121453,15864272 HuIFNAR1 also bound STAT1 and STAT2 via phospho-Tyr466 and phospho-Tyr48 when overexpressed in heterologous cells

Go back
830.0, 594.0
19.0, 19.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e41

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
834.0, 730.0
19.0, 19.0

p30

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e42

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
833.0, 797.0
21.0, 21.0

p32

p32

cso30:i:ME_Dimerization

cso30:i:CC_Cytoplasm

--

e43

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
861.0, 881.0
21.0, 21.0

p32

p33

cso30:i:ME_Dimerization

cso30:i:CC_Cytoplasm

--

e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
870.0, 978.0
19.0, 19.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e43 e44

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m43*m44*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
802.0, 822.0
19.0, 19.0

p35

p35

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e45

e48 e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
718.0, 1102.0
19.0, 19.0

p35

p36

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e47

e40 e39 e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
826.0, 938.0
19.0, 19.0

p35

p37

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e46

e49 e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
577.0, 1053.0
21.0, 21.0

p38

p38

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
709.0, 821.0
21.0, 21.0

p38

p39

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e48

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
678.0, 186.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007548 MO000000145 e25

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c65 : 1
stoichiometry:c12 : 1

m901*m129*0.1

nodelay

--

true

0

false

PMID: 17502368,9121453 Jak1, STAT1, and STAT2 may also be preassociated with IFNAR2 PMID: 17502368,16710296 Recently, a type I IFN-inducible cysteine protease, UBP43, was shown to interact directly with IFNAR2, blocking the interaction between Jak1 and the receptor

Go back
729.0, 905.0
21.0, 21.0

p38

p40

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e49

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
466.0, 982.0
19.0, 19.0

p41

p41

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e64 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c121 : 1

m64*m67*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
502.0, 926.0
19.0, 19.0

p41

p42

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e65 e67

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c122 : 1

m65*m67*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
530.0, 874.0
19.0, 19.0

p41

p43

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e66 e67

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c123 : 1

m66*m67*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
418.0, 770.0
19.0, 19.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
498.0, 754.0
19.0, 19.0

p44

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e69

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
594.0, 726.0
19.0, 19.0

p44

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 17502368 STAT proteins are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription. are in turn phosphorylated and form homo- and heterodimeric complexes, which dissociate from the receptor and then translocate to the nucleus and bind to an ISRE or GAS element within the promoters of interferon-regulated genes, leading to their transcription.

Go back
293.0, 53.0
19.0, 19.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000007545 MO000066363

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m898*m41221*0.1

nodelay

--

true

0

false

PMID: 17502368,15449939,11125298,15312780 The binding site of IFN{alpha}2 on IFNAR1 has been predicted from site-directed mutagenesis and epitope mapping with an anti-IFNAR1-neutralizing antibody , albeit the latter may be inaccurate because of steric hindrances

Go back
727.0, 39.0
17.0, 17.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000066363 MO000007548

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m41221*m901*0.1

nodelay

--

true

0

false

PMID: 17502368,12842042,15312780,9737924,10556041 Numerous studies have investigated the residues of IFNAR2 involved in ligand interactions with IFN{alpha}2 and IFNbeta

Go back
115.0, 727.0
17.0, 17.0

p48

p49

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000007548 MO000016660

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m901*m1636*0.1

nodelay

--

true

0

false

PMID: 17502368,12842042,15312780,9737924,10556041 Numerous studies have investigated the residues of IFNAR2 involved in ligand interactions with IFN{alpha}2 and IFNbeta

Go back
590.0, 310.0
19.0, 19.0

p4

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000013119 e12 e13 e14

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c6 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c7 : 1

m1357*m12*0.1

nodelay

--

true

0

false

PMID: 17502368,9121453 Jak1, STAT1, and STAT2 may also be preassociated with IFNAR2 PMID: 17502368,16311601 This may occur by binding a negative regulator such as SOCS-1 to inhibit JAK/STAT signaling

Go back
85.0, 361.0
21.0, 21.0

p50

p50

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

MO000007548 e75 e35

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c140 : 1

m901*m75*m35*0.1

nodelay

--

true

0

false

PMID: 17502368,15286706 In vitro studies demonstrate that a soluble IFNAR2 can also be generated by cleavage of transmembrane IFNAR2 by intramembrane proteases in response to IFNs and other stimuli, but there is no definitive in vivo evidence for this effect

Go back
84.0, 1068.0
23.0, 23.0

p51

p51

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e77 MO000042729

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c145 : 1
stoichiometry:c144 : 1

m77*m20522*0.1

nodelay

--

true

0

false

PMID: 17502368,15871661 Nevertheless, there is a precedent in the IL6 receptor system where the soluble IL6R{alpha} is generated both by alternative splicing and by cleavage by ADAM 10 and 17 proteases

Go back
112.0, 1132.0
23.0, 23.0

p51

p52

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

MO000017665 e77

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m2428*m77*0.1

nodelay

--

true

0

false

PMID: 17502368,15871661 Nevertheless, there is a precedent in the IL6 receptor system where the soluble IL6R{alpha} is generated both by alternative splicing and by cleavage by ADAM 10 and 17 proteases

Go back
466.0, 322.0
19.0, 19.0

p4

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000013120 e6 e13 e14

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c9 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c14 : 1

m1358*m6*0.1

nodelay

--

true

0

false

PMID: 17502368,9121453 Jak1, STAT1, and STAT2 may also be preassociated with IFNAR2 PMID: 17502368,16311601 This may occur by binding a negative regulator such as SOCS-1 to inhibit JAK/STAT signaling

Go back
267.9932582089723, 188.88514344942905

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
694.6906911759853, 130.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.0, 832.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.9164036654653, 140.76707132650338

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.9787730468599, 937.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.4278135270821, 952.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 552.5481680216777

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.5831498324341, 1028.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.0, 552.3229079210314

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.7316983290247, 140.96646832387492

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.3900277413852, 1119.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.7585397014369, 1081.5093580761338

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.0, 196.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.7339445046937, 994.5183473879075

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 832.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.164276602902, 842.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.1589675136782, 932.1143318680631

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.4906334205524, 905.8089875327071

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.85423880472223, 978.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
401.0, 946.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 936.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 936.2924872468058

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.9736910626624, 885.6482675660701

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.0, 137.4813492843222

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.0, 890.842822105693

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
405.25106175052315, 878.7770549646021

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 836.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
549.0, 809.0734677954727

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.0, 796.4581244641498

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
437.0, 725.4929882637098

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.40971801578524, 780.9895013078127

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0, 728.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.6784126030082, 751.4894110299791

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.5758296025207, 716.570370757998

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 336.9936076697743

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.0, 79.7336418228921

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.73897778704196, 50.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 68.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.0, 48.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 63.708143277039525

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 50.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
137.53985280894597, 130.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
95.0, 751.6626102817692

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
126.0, 744.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
113.41065543429899, 124.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
216.88526983219614, 334.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
96.0, 382.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
101.39927647036717, 389.6317411131892

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
104.10992885021298, 60.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
114.99049880899918, 1080.3897804297073

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
83.03471347254215, 1091.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
113.93525042446028, 1089.9877689940647

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
136.83862117262234, 1161.3708512106193

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
141.3148177390106, 1093.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
95.89738554393134, 1155.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
394.0, 148.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 257.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.6337770899679, 133.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 199.4031623927316

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.7988200239056, 195.0

c19

c19

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
261.8308170454446, 126.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.9997662732264, 320.0432407164673

c20

c20

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
632.816296796316, 202.0

c21

c21

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
633.3531157823314, 330.0

c22

c22

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
620.6288590584682, 203.0

c23

c23

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
621.1268525327462, 332.0

c24

c24

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
488.85851403087514, 195.0

c25

c25

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
488.99947559036826, 324.0

c26

c26

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
261.0, 142.3752317133721

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.0, 394.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.4892646301607, 357.8126349388826

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.0, 124.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.8476196058406, 222.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.3104923889621, 120.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 253.50745061307643

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 325.4574003243061

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 367.46988867442553

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 126.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.8665167399343, 439.45530559688785

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.02391845082263, 445.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 130.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.0638801595544, 229.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 357.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 122.810546048712

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.4301460975424, 130.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.0, 408.2849259317971

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 401.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.0, 529.8995250553337

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.35482044881545, 517.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
208.0, 625.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.1360870084131, 138.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
213.40945205373842, 666.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
208.0, 634.8592480260213

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 624.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
321.10493924633687, 233.71811056990185

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.0, 580.8676255087125

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.4299717028501, 203.0579830217101

c65

c65

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
92.0, 484.2933805021156

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.0, 496.8

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.2163006638537, 493.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
102.0, 818.1193153738147

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.0, 127.28628785522477

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
106.0, 660.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.88830464741122, 825.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.87469314597843, 54.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.70862959267885, 72.13939940237343

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.0, 77.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
135.94594513699568, 180.96911150685466

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.4524082737194, 60.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
126.0, 181.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
197.0, 165.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 130.34002320822526

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 216.96750495905803

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.0, 288.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 473.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.2855322440993, 133.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.0, 427.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 565.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.0, 264.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.7363155205315, 531.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 629.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.9195959492894, 585.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0, 612.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.1922606129452, 121.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.9221561791364, 662.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
853.0, 743.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.9494767642, 733.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.0, 811.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.968639888507, 800.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.0, 896.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.9656265869289, 745.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.760367953758, 809.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
889.0, 991.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.945204834583, 833.9347299805391

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back