1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17502370.csml convertedTime:2009.07.01.11:04

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The interferon regulatory factor family in host defense: mechanism of action.
Authors Ozato K, Tailor P, Kubota T.
Affiliation Laboratory of Molecular Growth Regulation, National Institute of Child Healthand Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ozatok@nih.gov
Abstract Transcription factors of the interferon regulatory factor (IRF) family commandsthe entire type I interferon (IFN) system from induction of IFNs to diverse IFNresponses, thereby providing a principal basis for host resistance againstpathogens. However, the family has various additional roles. Regulating thedevelopment of the immune system, IRFs shape the establishment and execution ofinnate and adaptive immunity. IRFs also regulate growth and differentiation ofmany cell types, thus playing a role in leukemia and other cancers. In addition,evidence indicates that IRFs confer antiviral mechanisms not directly ascribedto the IFN system. This review deals with the diverse roles of IRFs in hostdefense and discusses the molecular mechanisms by which they regulate targetgene transcription.
PMID 17502370
Model Abstract

Entity

MO000000212:TRAF6 MO000000248:IKK{active} MO000007185:IRF-8 MO000007685:IRF-1 MO000007690:IRF-2 MO000007694:IRF-3 MO000007697:IRF-4 MO000007702:IRF-7 MO000013119:STAT1 MO000013120:STAT2 MO000016608:IKK-i{active} MO000016884:SHP-1 MO000016886:SHP-2 MO000017197:Pin1 MO000017462:CBP MO000019331:TBK1 MO000019479:protein remnants MO000019984:p300 MO000023551:p/CAF MO000037579:PU.1 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000045015:PML e1: e10: e11:IFN e12:JAK e13:STAT1{active} e14:STAT2{active} e15:IFN:IFNR:JAK e16:IRF9 e17:Stat1:Stat2:IRF9 e18:ISRE e19:ISRE:Stat1:Stat2:IRF9 e2: e20:IFN stimulated genes e21:PU.1:IRF-4 e22:Ets e23:PU.1:IRF-4:Ets e24:PU.1:IRF-8 e25:PU.1:IRF-8:Ets e26:lysosomal protease e27:endosomal protease e28:INK4 e29:IRF-8 e3: e30:BCR/Abl protein e31:type I interferons e32:IL-12p40 e33:ligand:TLRs e34:IKK e35:(IRF-3{p})2 e36:(IRF-3{p})2 e37:IFN-alpha e38:IFN-beta e39:(IRF-7{p})2 e4: e40:(IRF-7{p})2 e41:NSP1 e42:NSP1:IRF-3 e43:ICP0 e44:PML:ICP0 e45:SUMO e46:PML{sumo} e47:P protein e48:PML:P protein e49:IRF-8 e5:INFR e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFN:IFNR e60: e61: e62: e63:IRF-8{p} e64:TBK1 e65:RIG-I:ligand e66:IKK-i e67:IRF-1{ace} e68:IRF-7{ace} e69:IRF-2{ace} e7: e70:IRF-3:pin1 e71:IRF-8:TRAF6 e72:IRF-8{ub}:TRAF6 e73:IRF-7{ub} e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p6 p7 p8 p9
Model Detail
667.0, 623.0
34.0, 34.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p57

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
635.0, 247.0
26.0, 26.0

IKK{active}

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p20 p26

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
715.0, 1139.0
34.0, 34.0

IRF-8

--

MO000007185

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58

p10 p12 p13 p14 p15 p16 p18 p19

true true true true

csml-variable:Double

m769

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007185

--

Go back
892.0, 632.0
32.0, 32.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p46 p47

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
367.0, 743.0
34.0, 34.0

IRF-2

--

MO000007690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52 p53

true true true true

csml-variable:Double

m974

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007690

--

Go back
522.0, 318.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p31 p37 p38

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
597.0, 1073.0
29.0, 29.0

IRF-4

--

MO000007697

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p18 p19

true true true true

csml-variable:Double

m978

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007697

--

Go back
878.0, 238.0
28.0, 28.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p43 p44 p48 p49 p50 p57

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1132.0, 616.0
24.0, 24.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1190.0, 730.0
28.0, 28.0

STAT2

--

MO000013120

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m1358

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013120

--

Go back
491.0, 215.0
34.0, 34.0

IKK-i{active}

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41 p42

p38 p44

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1077.0, 409.0
30.0, 30.0

SHP-1

--

MO000016884

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m1805

10

false

infinite

0

unit false false false
InterProIPR000242
TRANSPATHMO000016884

--

Go back
1105.0, 469.0
30.0, 30.0

SHP-2

--

MO000016886

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m1807

10

false

infinite

0

unit false false false
InterProIPR000242
TRANSPATHMO000016886

--

Go back
744.0, 492.0
32.0, 32.0

Pin1

--

MO000017197

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m2065

10

false

infinite

0

unit false false false
InterProIPR000297
TRANSPATHMO000017197

--

Go back
1025.0, 781.0
30.0, 30.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p50 p53

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
680.0, 380.0
24.0, 24.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39 p40

p37 p43

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
410.0, 642.0
28.0, 28.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
828.0, 600.0
32.0, 32.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p49 p51

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
987.0, 675.0
34.0, 34.0

p/CAF

--

MO000023551

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p48 p52

true true true true

csml-variable:Double

m7326

10

false

infinite

0

unit false false false
InterProIPR001487
TRANSPATHMO000023551

--

Go back
718.0, 1006.0
28.0, 28.0

PU.1

--

MO000037579

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p10

true true true true

csml-variable:Double

m15836

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000037579

--

Go back
582.0, 442.0
28.0, 28.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20 p37 p38

p22 p54

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
819.0, 359.0
26.0, 26.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p43 p44

p27

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
1018.0, 1078.0
36.0, 36.0

PML

--

MO000045015

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34 p35

true true true true

csml-variable:Double

m22678

10

false

infinite

0

unit false false false
TRANSPATHMO000045015

--

Go back
234.13850301678627, 108.39270399230375
1049.7128406518138, 1524.1830446264335

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
291.2524131473631, 124.68913606489389
1017.4931924607328, 1431.3268184065116

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1392.0, 375.13444639718807
40.562390158172235, 26.365553602811957

IFN

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1170.0, 591.2200000000001
35.04, 26.28

JAK

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1088.0, 708.0
24.0, 24.0

STAT1{active}

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p5

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1170.0, 806.0
28.0, 28.0

STAT2{active}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p5

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013120

--

Go back
1250.5, 621.7181134153055
26.002018719031017, 36.28188658469444

IFN:IFNR:JAK

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p2 p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1184.0, 886.2750233863424
15.480823199251635, 35.72497661365762

IRF9

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1143.5, 950.2266470912094
24.9209029179666, 34.773352908790606

Stat1:Stat2:IRF9

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
806.0, 1057.5
60.0, 13.0

ISRE

--

e18

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
906.0, 1131.5
60.0, 17.0

ISRE:Stat1:Stat2:IRF9

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
234.13850301678627, 108.39270399230375
1049.7128406518138, 1524.1830446264335

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
912.0, 1290.923875432526
48.892733564013845, 26.07612456747405

IFN stimulated genes

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p7

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
666.0, 1108.8342541436464
27.149171270718234, 30.165745856353585

PU.1:IRF-4

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
582.0, 1237.5
60.0, 13.0

Ets

--

e22

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p9 p11

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
566.0, 1179.5
60.0, 17.0

PU.1:IRF-4:Ets

--

e23

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p9

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
779.5, 1036.5250791534745
24.887852024662553, 30.474920846525578

PU.1:IRF-8

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
838.0, 1187.5
60.0, 17.0

PU.1:IRF-8:Ets

--

e25

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p11

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
743.0, 1376.2179930795849
42.71626297577855, 22.782006920415228

lysosomal protease

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p14

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
582.0, 1345.937716262976
41.36678200692042, 22.062283737024224

endosomal protease

--

e27

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p15

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
679.0, 1401.1314878892736
41.003460207612456, 21.868512110726645

INK4

--

e28

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
855.0, 1422.7301038062285
49.2560553633218, 26.26989619377163

IRF-8

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17

p58

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
255.13275982982242, 129.3869608053401
1007.7243270257416, 1482.194531000362

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1156.5, 1344.4087341517409
23.797947273093182, 38.59126584825921

BCR/Abl protein

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
820.0, 1321.0726643598618
39.23875432525952, 20.927335640138413

type I interferons

--

e31

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
749.0, 1451.5847750865053
45.778546712802765, 24.41522491349481

IL-12p40

--

e32

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
602.5, 128.77154132865604
19.751370313527733, 38.228458671344

ligand:TLRs

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p21 p40 p42 p55 p57

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
755.0, 191.0
26.0, 26.0

IKK

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
582.5, 686.8856857190469
27.86002332944509, 34.114314280953174

(IRF-3{p})2

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
543.5, 1105.0249958340278
24.47958673554407, 29.97500416597233

(IRF-3{p})2

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24 p25

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
488.0, 1233.159169550173
40.95155709342561, 21.84083044982699

IFN-alpha

--

e37

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p24 p30

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
538.0, 1298.539792387543
36.48788927335641, 19.460207612456752

IFN-beta

--

e38

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p25 p29

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
818.0, 471.9558011049724
28.839779005524864, 32.04419889502763

(IRF-7{p})2

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
293.9721349339398, 166.12691022815326
930.0455768175078, 1408.7146321547345

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
974.0, 1211.9558011049724
28.839779005524857, 32.04419889502762

(IRF-7{p})2

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29 p30

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
382.0, 430.673878043872
28.907224793721074, 17.82612195612799

NSP1

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p32

p31

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
447.5, 400.7950341609731
24.66738876853857, 30.204965839026823

NSP1:IRF-3

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p32

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1086.0, 1232.975678203929
19.943872778297475, 46.02432179607109

ICP0

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1008.0, 1290.524861878453
31.027624309392266, 34.47513812154696

PML:ICP0

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1004.0, 1147.5588235294117
40.73529411764706, 24.441176470588232

SUMO

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
917.0, 1036.0
29.999999999999996, 23.0

PML{sumo}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
791.5, 965.962165425639
17.28999798752264, 28.03783457436104

P protein

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
827.5, 1012.3651058156975
25.01849691718047, 30.634894184302624

PML:P protein

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
951.0, 415.0
34.0, 34.0

IRF-8

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p55

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007185

--

Go back
1249.5, 458.555360281195
28.239015817223198, 43.444639718804915

INFR

--

e5

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
456.33804376430743, 940.3281757670654
668.8871695209901, 606.6071723588881

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
528.582840472347, 954.703883883854
391.1183821780094, 587.923173210257

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
465.057243367002, 948.4245753981388
651.4487703156019, 590.4143730967413

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
466.3028433102438, 949.6701753413809
648.9575704291174, 587.923173210257

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
456.33804376430743, 940.3281757670654
668.8871695209901, 606.6071723588881

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
456.33804376430743, 940.3281757670654
668.8871695209901, 606.6071723588881

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
466.3028433102438, 949.6701753413809
648.9575704291174, 587.923173210257

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
944.6132215151983, 1189.4481644154787
41.788395148393576, 37.82949455538797

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
835.0004265098962, 1363.8321564693686
118.3319946079964, 107.1215951188181

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
456.33804376430743, 940.3281757670654
668.8871695209901, 606.6071723588881

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1248.5, 529.943871957904
22.762332821749617, 44.05612804209603

IFN:IFNR

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
613.9909860513538, 1209.8993907270249
21.18267383227404, 10.199065178502341

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
613.2836366128075, 1179.4833648695426
72.50331745097698, 130.50597141175865

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
643.6996624702913, 1264.3652974950774
11.317591016737849, 11.31759101673787

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1008.0, 551.219512195122
40.97560975609756, 32.78048780487805

IRF-8{p}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
644.0, 300.0
24.0, 24.0

TBK1

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p40

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
892.5, 193.09615064155975
30.138143642726217, 36.90384935844026

RIG-I:ligand

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p39 p41

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
343.0, 319.0
34.0, 34.0

IKK-i

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p42

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
942.0, 861.9139258222533
36.63400979706088, 28.086074177746674

IRF-1{ace}

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p45 p46 p47

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
954.0, 261.9139258222533
36.63400979706088, 28.086074177746674

IRF-7{ace}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p48 p49 p50

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
382.0, 917.9139258222533
36.63400979706088, 28.086074177746674

IRF-2{ace}

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

p51 p52 p53

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
247.93019864939106, 114.52613705543014
1029.4412600394198, 1458.6916747422038

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
651.5, 528.235294117647
25.941176470588236, 31.764705882352942

IRF-3:pin1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
747.5, 795.0568238626896
33.43692717880353, 40.943176137310445

IRF-8:TRAF6

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p56

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
812.5, 857.6062322946176
30.53824362606232, 37.39376770538244

IRF-8{ub}:TRAF6

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1147.0, 236.38908327501753
41.23163051084675, 31.610916724982502

IRF-7{ub}

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

p57

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
251.60798415141886, 140.2706355696257
987.5552673414793, 1433.9302481798293

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
261.41541215682673, 166.01513408382132
983.0465358380362, 1415.1246122853602

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1352.0, 468.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m11*m5*0.1

nodelay

--

true

0

false

PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.

Go back
721.0, 1073.0
21.0, 21.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007185 MO000037579

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m769*m15836*0.1

nodelay

--

true

0

false

PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor

Go back
781.0, 1185.0
21.0, 21.0

p11

p11

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e24 e22

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m24*m22*0.1

nodelay

--

true

0

false

PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor

Go back
1359.0, 1107.0
25.0, 25.0

p12

p12

cso30:i:CE_CellDifferentiation

cso30:i:CC_Cytosol

--

MO000007185

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17502370, 11846985 IRF-8 coordinates myeloid cell growth and differentiation. PMID: 17502370 IRF-8 promotes macrophage differentiation while inhibiting granulocyte development.

Go back
1356.0, 1200.0
23.0, 23.0

p13

p13

cso30:i:CE_CellGrowth

cso30:i:CC_Cytosol

--

MO000007185

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17502370, 11846985 IRF-8 coordinates myeloid cell growth and differentiation

Go back
741.0, 1273.0
21.0, 21.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007185

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17502370, 15947094 It directly stimulates the expression of genes active in macrophages including those for lysosomal and endosomal proteases.

Go back
621.0, 1289.0
21.0, 21.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000007185

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17502370, 15947094 It directly stimulates the expression of genes active in macrophages including those for lysosomal and endosomal proteases.

Go back
688.0, 1276.0
24.0, 24.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000007185

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17502370 In myeloid cells IRF-8 negatively regulates cell growth as it inhibits c-myc and stimulates expression of tumor suppressor/inhibitor of cyclin-dependent kinase (INK4).

Go back
903.0, 1351.0
25.0, 25.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e30

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c42 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17502370, 11846985 This growth regulation is relevant to CML in humans, where IRF-8 expression is down-regulated by the Bcr/Abl oncoprotein resulting in abnormal growth promotion.

Go back
830.0, 1262.0
19.0, 19.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000007185 MO000007697

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c48 : 1
stoichiometry:c44 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17502370, 15728463, 10861061 IRF-8, but not IRF-4, is required for the expression of proinflammatory cytokines including type I IFN and IL-12p40, indicating that IRF-8 is critically required for cytokine gene expression. PMID: 17502370, 16236719 IRF-4, on the other hand, inhibits expression of proinflammatory cytokine genes.

Go back
797.0, 1409.0
21.0, 21.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000007185 MO000007697

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c46 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17502370, 15728463, 10861061 IRF-8, but not IRF-4, is required for the expression of proinflammatory cytokines including type I IFN and IL-12p40, indicating that IRF-8 is critically required for cytokine gene expression. PMID: 17502370, 16236719 IRF-4, on the other hand, inhibits expression of proinflammatory cytokine genes.

Go back
1132.0, 660.0
23.0, 23.0

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013119 e15

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c11 : 1
stoichiometry:c8 : 1

m1357*m15*0.1

nodelay

--

true

0

false

PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.

Go back
586.0, 322.0
19.0, 19.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000000248

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c54 : 1
stoichiometry:c51 : 1

m977*m207*0.1

nodelay

--

true

0

false

PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
722.0, 238.0
19.0, 19.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 e33

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c59 : 1
stoichiometry:c53 : 1

m34*m33*0.1

nodelay

--

true

0

false

PMID: 17502370 RF-3 and IRF-7 are early IRFs activated by Toll-like receptor (TLR)and other types of signaling that play a pivotal role in the initial induction of type I IFNs. PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
584.0, 544.0
23.0, 23.0

p22

p22

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
583.0, 811.0
25.0, 25.0

p23

p23

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
498.0, 1170.0
19.0, 19.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
593.0, 1141.0
21.0, 21.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e36

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c62 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
822.0, 294.0
19.0, 19.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000000248

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1

m980*m207*0.1

nodelay

--

true

0

false

--

Go back
790.0, 410.0
19.0, 19.0

p27

p27

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041457

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m19325*0.1

nodelay

--

true

0

false

--

Go back
773.0, 593.0
21.0, 21.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m39*0.1

nodelay

--

true

0

false

--

Go back
579.0, 1399.0
25.0, 25.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e40

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
1358.0, 594.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e12

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m6*m12*0.1

nodelay

--

true

0

false

PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.

Go back
488.0, 1304.0
23.0, 23.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e40

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.

Go back
450.0, 322.0
19.0, 19.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007694 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m977*m41*0.1

nodelay

--

true

0

false

PMID: 17502370, 15741273 the rotavirus regulatory protein NSP1 binds to and degrades IRF-3 to disable IFN induction.

Go back
413.0, 525.0
21.0, 21.0

p32

p32

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e42

MO000019479 e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17502370, 15741273 the rotavirus regulatory protein NSP1 binds to and degrades IRF-3 to disable IFN induction.

Go back
1066.0, 1154.0
19.0, 19.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000045015 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m22678*m43*0.1

nodelay

--

true

0

false

PMID: 17502370 ICP0 interacts with PML and affects SUMO (small ubiquitin-related modifier) modification of PML, thereby counteracting PML inhibition of viral replication.

Go back
962.0, 1074.0
19.0, 19.0

p34

p34

cso30:i:ME_Sumoylation

cso30:i:CC_Nucleoplasm

--

MO000045015 e45 e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c87 : 1
stoichiometry:c86 : 1

m22678*m45*0.1

nodelay

--

true

0

false

PMID: 17502370 ICP0 interacts with PML and affects SUMO (small ubiquitin-related modifier) modification of PML, thereby counteracting PML inhibition of viral replication.

Go back
873.0, 969.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 MO000045015

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m47*m22678*0.1

nodelay

--

true

0

false

PMID: 17502370, 16689655 Additionally, infection with rabies virus, an RNA virus, also alters PML distribution through the interaction of the viral P protein with PML

Go back
958.0, 474.5
19.5, 19.5

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e49 MO000016884 MO000016886

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c92 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17502370, 16914719 IRF-8 is phosphorylated at the tyrosine residues in the DBD, which is inhibited by the protein tyrosine phosphatases SHP1 and SHP2.

Go back
550.0, 382.0
19.0, 19.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000019331

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c97 : 1
stoichiometry:c96 : 1

m977*m3902*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
499.0, 375.0
17.0, 17.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000016608

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m977*m1599*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
701.0, 329.0
21.0, 21.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e65

MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m64*m65*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
1130.0, 758.0
19.0, 19.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013120 e15

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c12 : 1
stoichiometry:c10 : 1

m1358*m15*0.1

nodelay

--

true

0

false

PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.

Go back
641.0, 349.0
21.0, 21.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e33

MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c105 : 1

m64*m33*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
405.0, 265.0
21.0, 21.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e65

MO000016608

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m66*m65*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
357.0, 233.0
21.0, 21.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e33

MO000016608

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m66*m33*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
845.0, 313.0
21.0, 21.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000019331

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c114 : 1

m980*m3902*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
773.0, 253.0
21.0, 21.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000016608

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1

m980*m1599*0.1

nodelay

--

true

0

false

PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.

Go back
905.0, 749.0
21.0, 21.0

p45

p45

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007685 MO000023551

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c121 : 1
stoichiometry:c120 : 1

m970*m7326*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
855.0, 743.0
25.0, 25.0

p46

p46

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007685 MO000019984

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m970*m4512*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
958.0, 750.0
19.0, 19.0

p47

p47

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007685 MO000017462

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m970*m2282*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
892.0, 404.0
23.0, 23.0

p48

p48

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007702 MO000023551

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m980*m7326*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
961.0, 349.0
21.0, 21.0

p49

p49

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007702 MO000019984

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m980*m4512*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
1096.0, 868.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e13 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m14*m13*m16*0.1

nodelay

--

true

0

false

PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.

Go back
1012.0, 328.0
23.0, 23.0

p50

p50

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007702 MO000017462

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c136 : 1
stoichiometry:c135 : 1

m980*m2282*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
354.0, 838.0
19.0, 19.0

p51

p51

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007690 MO000019984

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m974*m4512*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
389.0, 845.0
21.0, 21.0

p52

p52

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007690 MO000023551

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c141 : 1

m974*m7326*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
456.0, 752.0
23.0, 23.0

p53

p53

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

MO000007690 MO000017462

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c145 : 1
stoichiometry:c144 : 1

m974*m2282*0.1

nodelay

--

true

0

false

PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.

Go back
664.0, 448.0
23.0, 23.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017197 MO000041456

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m2065*m19324*0.1

nodelay

--

true

0

false

PMID: 17502370, 16699525 The peptidylprolyl isomerase Pin1 interacts with IRF-3 and changes the isomerization status in a phosphorylation-dependent manner, leading to rapid destabilization of IRF-3.

Go back
754.0, 630.0
19.0, 19.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e49 e33

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m183*m49*m33*0.1

nodelay

--

true

0

false

PMID: 17502370, 16484229 In a separate study, TRAF6 was shown to associate with IRF-8 in TLR-stimulated macrophages, consistent with the involvement of IRF-8 in ubiquitination-coupled transcription.

Go back
736.0, 864.0
23.0, 23.0

p56

p56

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 17502370, 16484229 In a separate study, TRAF6 was shown to associate with IRF-8 in TLR-stimulated macrophages, consistent with the involvement of IRF-8 in ubiquitination-coupled transcription.

Go back
1073.0, 245.0
21.0, 21.0

p57

p57

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000007702 MO000000212 e33

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c156 : 1

m980*m183*m33*0.1

nodelay

--

true

0

false

PMID: 17502370, 15361868 IRF-7 is ubiquitinated upon TLR stimulation through an E3 ubiquitin ligase, TRAF6.

Go back
803.0, 1343.0
25.0, 25.0

p17

p58

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e29

MO000007185

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17502370, 11846985 This growth regulation is relevant to CML in humans, where IRF-8 expression is down-regulated by the Bcr/Abl oncoprotein resulting in abnormal growth promotion.

Go back
826.0, 1102.0
19.0, 19.0

p6

p6

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e18 e17

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m18*m17*0.1

nodelay

--

true

0

false

PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.

Go back
925.0, 1205.5
21.5, 21.5

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.

Go back
662.0, 1042.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000007697 MO000037579

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m978*m15836*0.1

nodelay

--

true

0

false

PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor

Go back
669.0, 1177.0
21.0, 21.0

p9

p9

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e21 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m21*m22*0.1

nodelay

--

true

0

false

PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor

Go back
1373.748021039078, 402.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1148.0, 777.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 249.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 318.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.7540371932674, 350.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.7102372937744, 222.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.6379617782632, 324.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 368.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 167.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
376.0, 291.8307845767519

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 243.44378019905318

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.93261371797087, 214.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1162.7417938761957, 644.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
361.0, 261.96613343214375

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.0, 233.7052085783768

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.4504306858588, 152.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.5164229118466, 266.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.4618485406781, 334.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.0, 332.04335913855124

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
801.9544732313585, 254.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 274.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 234.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
909.0, 664.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1154.574285474106, 654.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.0, 770.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.3371279422537, 705.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
875.7568302382338, 664.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 768.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.0, 632.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
917.0, 664.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.5150582239837, 769.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.1554175279994, 768.5777087639997

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
893.0, 266.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.7290745363287, 434.5201165001057

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1125.2948273388472, 831.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.0, 297.20526615977377

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
902.0, 266.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 298.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0, 377.1554175279993

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
906.0, 261.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0570138197744, 296.198920166175

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1024.2789001258805, 358.9951369419031

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
367.78953928575106, 777.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 857.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.20227471598156, 624.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1101.0, 732.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
387.0, 777.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 866.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.72272489189686, 697.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
401.0, 761.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.00684419244635, 775.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.98795143748316, 765.438898430631

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.923410283849, 470.00829016433363

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.0, 457.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.1119090269775, 471.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.0, 640.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1126.6786755654036, 885.2445359345026

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.5936550366953, 449.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 649.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.0, 167.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.197769023179, 836.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.0, 876.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.0, 252.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.0, 253.45210649618124

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.0, 271.5396103873361

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.0, 150.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
829.9975603804354, 1374.2469504755443

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1114.0, 891.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.1199469180214, 1180.3665413342171

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.0, 1071.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.3003888280116, 974.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 1115.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1278.0, 480.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 1149.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
936.0, 1227.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.0, 1062.1716000756319

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.037652108609, 1027.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 1061.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
680.0, 1139.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.0, 1202.1337810613895

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 1188.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.0, 1102.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.0, 1034.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1277.5804608257931, 488.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.0, 1062.725971462661

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 1067.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.0, 1196.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.0, 1201.0778770324407

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
749.0, 1121.4452106095684

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.0, 1157.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.0, 1173.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.0, 1294.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.5777087639997, 1310.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.5418636464293, 1173.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1271.0, 557.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
704.8869603991079, 1173.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
700.0, 1300.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.5164229118466, 1376.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0, 1364.0

c43

c43

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
840.0, 1281.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 1173.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
787.0659023220582, 1430.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.0, 1173.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
626.0, 1099.0

c48

c48

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
620.0, 1102.0

c49

c49

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1205.0, 604.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 332.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 341.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.0335858293437, 217.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.9143229085959, 249.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.7366114716856, 273.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.0, 470.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 567.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.0, 721.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.0611712483466, 836.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.0, 157.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1284.5609976974654, 608.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.9975603804354, 1135.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0, 1189.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.3448392430674, 1162.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 1128.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0509053796171, 264.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 313.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.0, 263.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
811.3124295713869, 385.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 429.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.9998372528277, 504.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 640.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 614.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.2544661759725, 1234.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
561.6136782164077, 1325.5609976974654

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 1262.9406911095632

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.8744727930927, 1231.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.0, 332.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 347.8935038988384

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 341.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
429.28381269280135, 431.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 546.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1116.4164522465671, 683.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.22446461232846, 456.6845141153165

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.0, 1114.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.6940267760465, 1180.8185851202143

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.7390583929491, 1173.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.8605619655765, 1087.4871333448389

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
982.4654135385309, 1099.6377768816

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.9792745494693, 1064.3149107106394

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
974.9051856628453, 1096.8962339400732

c87

c87

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
809.0, 980.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.3752370762162, 992.8328410093897

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1156.4526209558805, 749.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.4057970281387, 990.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.0, 449.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.0, 494.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.5992564287848, 431.0

c93

c93

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
982.0, 484.0

c94

c94

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
542.0, 346.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.0, 401.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 392.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.6753833509902, 346.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 391.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back