1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17535871.csml convertedTime:2009.07.01.11:04

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Critical role of toll-like receptors and nucleotide oligomerisation domain inthe regulation of health and disease.
Authors Mitchell JA, Paul-Clark MJ, Clarke GW, McMaster SK, Cartwright N.
Affiliation Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine,Royal Brompton Hospital, National Heart and Lung Institute, Imperial College,London SW3 6LY, UK. j.a.mitchell@imperial.ac.uk
Abstract Pathogens are sensed by pattern recognition receptors (PRRs), which are germline-encoded receptors, including transmembrane Toll-like receptors (TLRs) andcytosolic nucleotide oligomerisation domain (NOD) proteins, containingleucine-rich repeats (NLRs). Activation of PRRs by specific pathogen-associatedmolecular patterns (PAMPs) results in genomic responses in host cells involvingactivation transcription factors and the induction of genes. There are now atleast 10 TLRs in humans and 13 in mice, and 2 NLRs (NOD1 and NOD2). TLRsignalling is via interactions with adaptor proteins including MyD88 andtoll-receptor associated activator of interferon (TRIF). NOD signalling is viathe inflammasome and involves activation of Rip-like interactive clarp kinase(RICK). Bacterial lipopolysaccharide (LPS) from Gram-negative bacteria is thebest-studied PAMP and is activated by or 'sensed' by TLR4. Lipoteichoic acid(LTA) from Gram-positive bacteria is sensed by TLR2. TLR4 and TLR2 havedifferent signalling cascades, although activation of either results in symptomsof sepsis and shock. This review describes the rapidly expanding field ofpathogen-sensing receptors and uses LPS and LTA as examples of how thesepathways parallel and diverge from each other. The role of pathogen-sensingpathways in disease is also discussed.
PMID 17535871
Model Abstract

Entity

G010329:TNF-alpha G010389:IL-1beta MO000000058:NF-kappaB MO000000212:TRAF6 MO000000213:IRAK MO000000290:LDL MO000016573:MyD88 MO000016597:IL-1beta MO000016828:Caspase-1 MO000016882:LPS MO000017264:IL-8 MO000017426:fibrinogen MO000017949:RIP2 MO000018132:CD14 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019420:LBP MO000019422:TLR6 MO000020434:Nod1 MO000020461:Nod2 MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022185:flagellin MO000022224:dsRNA MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 e1: e10: e11:Mal e12:flagellin:TLR5 e13:ssRNA e14:ssRNA: TLR7 e15:ssRNA: TLR8 e16:CpG DNA e17:CpG DNA: TLR9 e18:LPS:LBP:CD14: TLR4: MD2: Mal: MyD88 e19:LTA e2: e20:LTA: TLR1: TLR2 e21:LTA:TLR1: TLR2: Mal: MyD88 e22:TLR1: TLR2 e23:TLR6: TLR2 e24:LTA: TLR6: TLR2 e25:LTA:TLR6: TLR2: Mal: MyD88 e26:FSL-1 e27:Pam3CSK4: TLR1: TLR2 e28:CD36 e29:Pam3CSK4 e3: e30:LPS:LBP:CD14: TLR4: MD2: TRAM: TRIF e31:FSL-1: TLR6: TLR2 e32:IRAK{p} e33:TRAF6 {activated} e34:NF-kappaB {activated} e35:COX-2 e36:endothelin-1 e37:Nos2 e38:R-MALP2 e39:R_MALP2: TLR6: TLR2 e4: e40:PepG e41:PepG: NOD1 e42:PepG: NOD2 e43:PepG: NOD2: RIP2 e44:PepG: NOD1: RIP2 e45:Caspase-1 [activated} e46:IL-8 e47:dsRNA:TLR3: TRIF e48:ssRNA: TLR7: MyD88 e49:ssRNA: TLR8: MyD88 e5:TLR4: MD-2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:LBP:CD14: TLR4: MD2 e60: e61: e62: e63:TLR e64:HSP e65:TLR: HSP e66:hyaluronic acid e67:hyaluronic acid: TLR e68:soluble heparan sulphate e69:soluble heparan sulphate: TLR e7: e70:fibrinogen: TLR e71:LDL: TLR e72:beta-defensin 2 e73:beta-defensin 2: TLR e8: e9:

Process

p1 p10 p11 p12 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p5 p6 p7 p8 p9
Model Detail
620.0, 1024.0
40.0, 40.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p17 p23

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
740.0, 1020.0
40.0, 40.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p33

p34

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
608.0, 656.0
40.0, 40.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
617.0, 405.0
37.0, 37.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
625.0, 277.0
38.0, 38.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1221.0, 805.0
38.0, 38.0

LDL

--

MO000000290

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m290118

10

false

infinite

0

unit false false false
TRANSPATHMO000000290

--

Go back
427.0, 429.0
38.0, 38.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p11 p15 p38 p39

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
979.0, 1067.0
42.0, 42.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
824.0, 404.0
32.0, 32.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
357.0, 29.0
38.0, 38.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
982.0, 1006.0
36.0, 36.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
1219.0, 751.0
34.0, 34.0

fibrinogen

--

MO000017426

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m2254

10

false

infinite

0

unit false false false
TRANSPATHMO000017426

--

Go back
861.0, 265.0
38.0, 38.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p31

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
490.0, 90.0
35.5, 35.5

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p10

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
413.0, 202.0
34.0, 34.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
366.0, 203.0
32.0, 32.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p12

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
313.0, 913.0
30.0, 30.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
257.0, 765.0
30.0, 30.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
378.0, 82.0
36.0, 36.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
312.0, 201.0
35.0, 35.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
858.0, 186.0
36.0, 36.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
1037.0, 185.0
38.0, 38.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
434.0, 90.0
36.0, 36.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
551.0, 27.0
42.0, 42.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
107.0, 807.0
34.0, 34.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
118.0, 962.0
36.0, 36.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
756.0, 316.0
32.0, 32.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p37

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
731.0, 251.0
34.0, 34.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
311.0, 963.0
33.0, 33.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p37

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
254.0, 1195.0
34.0, 34.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
252.0, 1241.0
38.0, 38.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
256.0, 1008.0
31.0, 31.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
238.75, 169.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
247.0, 189.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
434.5, 300.0
24.177701750855306, 39.20708392030589

Mal

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9 p11 p15

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
250.0, 810.0
36.0, 36.0

flagellin:TLR5

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

--

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000042020

--

Go back
170.0, 1140.5
42.11132437619961, 23.16122840690979

ssRNA

--

e13

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p6 p7

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
254.5, 1050.0
31.0, 60.0

ssRNA: TLR7

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p38

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
255.5, 1118.0
31.0, 60.0

ssRNA: TLR8

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p39

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
181.0, 1251.5
46.45879732739421, 16.260579064587972

CpG DNA

--

e16

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
252.5, 1282.0
39.4755536066652, 76.40429730322299

CpG DNA: TLR9

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
674.5, 159.0
42.65643499232625, 82.56084192063143

LPS:LBP:CD14: TLR4: MD2: Mal: MyD88

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p20

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
128.0, 363.0
46.930193439865434, 26.593776282590404

LTA

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10 p14

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
238.75, 169.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
256.5, 289.0
28.403639552729672, 54.97478623108967

LTA: TLR1: TLR2

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
257.5, 357.0
27.866695900021938, 53.93554045165532

LTA:TLR1: TLR2: Mal: MyD88

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p17

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
254.0, 204.5
39.04, 29.279999999999998

TLR1: TLR2

--

e22

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p46

p10 p16

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
252.0, 245.5
36.80000000000001, 27.599999999999994

TLR6: TLR2

--

e23

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p14 p19 p27

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
256.5, 420.0
28.53277789958343, 55.22473141854856

LTA: TLR6: TLR2

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p15

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
255.5, 483.0
30.102828327121262, 58.263538697654006

LTA:TLR6: TLR2: Mal: MyD88

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
181.0, 635.5
37.328646748681905, 24.263620386643236

FSL-1

--

e26

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p19

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
239.0, 557.5
58.73213926343329, 36.218152545783866

Pam3CSK4: TLR1: TLR2

--

e27

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
322.0, 686.0
35.5, 35.5

CD36

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p27

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
172.0, 503.5
39.929701230228474, 25.954305799648502

Pam3CSK4

--

e29

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p16

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
255.87518862352903, 187.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
794.5, 145.0
35.92085069063802, 69.52422714317036

LPS:LBP:CD14: TLR4: MD2: TRAM: TRIF

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p24

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
240.0, 606.5
56.43791507345542, 34.803380961964194

FSL-1: TLR6: TLR2

--

e31

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
674.0, 351.5
51.94606560676192, 32.033407124169855

IRAK{p}

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
677.0, 469.0
37.0, 37.0

TRAF6 {activated}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p22

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
616.0, 796.0
40.0, 40.0

NF-kappaB {activated}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

p23

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
512.0, 1031.0
47.2318339100346, 25.190311418685123

COX-2

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
460.0, 1093.0
55.536332179930795, 29.619377162629757

endothelin-1

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
679.0, 1019.0
42.0, 42.0

Nos2

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24

--

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
Affymetrix104420_at
EnsemblENSMUSG00000020826
MGDNos2
ProteomeHumanPSD/Nos2
RefSeqNM_010927
TRANSFACG001073
UnigeneMm.2893

--

Go back
176.0, 738.5
40.4920913884007, 26.319859402460455

R-MALP2

--

e38

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p27

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
244.0, 710.5
56.43791507345542, 34.803380961964194

R_MALP2: TLR6: TLR2

--

e39

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
287.5567875770579, 217.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
948.0, 63.5
39.50790861159929, 25.68014059753954

PepG

--

e40

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p28 p29

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
924.5, 170.0
31.0, 60.0

PepG: NOD1

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p30

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
988.5, 170.0
31.0, 60.0

PepG: NOD2

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p31

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1031.0, 266.5
57.959347957335474, 35.74159790702356

PepG: NOD2: RIP2

--

e43

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1043.0, 340.5
50.58160595693299, 31.191990340108678

PepG: NOD1: RIP2

--

e44

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p32

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
824.0, 456.0
32.0, 32.0

Caspase-1 [activated}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p33 p35

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
833.0, 1024.0
45.77854671280277, 24.415224913494814

IL-8

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35

p36

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
313.0, 874.5
45.3048903199839, 27.938015697323408

dsRNA:TLR3: TRIF

--

e47

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
324.5, 1362.0
31.0, 60.0

ssRNA: TLR7: MyD88

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
452.5, 1354.0
31.0, 60.0

ssRNA: TLR8: MyD88

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
494.0, 199.0
40.0, 40.0

TLR4: MD-2

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000022133

--

Go back
443.0, 889.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
493.29367619468036, 899.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
449.06992643728904, 894.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
449.93705878547314, 895.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
443.0, 889.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
443.0, 889.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
449.93705878547314, 895.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
782.9158804881849, 1062.426469636829
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
706.6082338479803, 1183.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
443.0, 889.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
555.5, 175.0
37.67441350581013, 72.91821968866476

LPS:LBP:CD14: TLR4: MD2

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p9 p18 p25 p26

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
552.7511016961721, 1076.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
552.2586758712023, 1055.489410851356
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
573.4329863449013, 1114.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1050.5, 635.0
27.759226713532517, 42.70650263620387

TLR

--

e63

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p40 p41 p42 p43 p44 p45

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1214.0, 522.5
35.839999999999996, 26.880000000000003

HSP

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p40

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1047.5, 512.0
25.23635167726376, 48.84455163341372

TLR: HSP

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1199.0, 462.0
50.28595458368376, 28.495374264087467

hyaluronic acid

--

e66

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1048.5, 450.0
25.406270554702914, 49.17342688007016

hyaluronic acid: TLR

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1212.0, 586.0
47.66190075693861, 27.008410428931874

soluble heparan sulphate

--

e68

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1052.5, 577.0
23.999342249506686, 46.45033983775489

soluble heparan sulphate: TLR

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
250.0, 175.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1046.5, 743.0
26.147116860337643, 50.607322955492215

fibrinogen: TLR

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1047.5, 799.0
25.671344003508004, 49.6864722648542

LDL: TLR

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1215.0, 696.5
42.39999999999999, 31.79999999999999

beta-defensin 2

--

e72

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p45

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1051.5, 688.0
24.699408024556018, 47.80530585397939

beta-defensin 2: TLR

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
253.0, 196.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
261.0, 217.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
437.0, 33.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019420

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1

m155666*m3985*0.1

nodelay

--

true

0

false

PMID: 17535871, 2402637 LBP binds to the amphipathic lipid A moiety of LPS and facilitates its presentation and transfer to CD14.

Go back
184.0, 301.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e19 e22 MO000018132

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c41 : 1
stoichiometry:c79 : 1
stoichiometry:c31 : 1

m19*m22*m2828*0.1

nodelay

--

true

0

false

PMID: 17535871 LTA from Gram-positive bacteria is sensed by TLR2. PMID: 17535871, 16880211 while CD36 facilitates TLR2/TLR6 signalling, CD14 enhanced the sensing of ligands by the TLR2/TLR1 complex.

Go back
320.0, 305.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e11 MO000016573

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m20*m11*m1572*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR2, on the other hand, recruits just MyD88/Mal pathways.

Go back
313.0, 265.0
30.0, 30.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019422 MO000019397

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 17535871, 16880211, 11095740, 10549626 TLR2 is not thought to act as a monomeric receptor, but heterodimerises with either TLR1 or TLR6 to evoke effects.

Go back
180.0, 433.0
30.0, 30.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e19 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c48 : 1
stoichiometry:c43 : 1

m19*m23*0.1

nodelay

--

true

0

false

PMID: 17535871 LTA from Gram-positive bacteria is sensed by TLR2.

Go back
325.0, 433.0
30.0, 30.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000016573 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m11*m1572*m24*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR2, on the other hand, recruits just MyD88/Mal pathways.

Go back
105.0, 529.0
30.0, 30.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e22 e29

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c52 : 1
stoichiometry:c51 : 1

m22*m29*0.1

nodelay

--

true

0

false

PMID: 17535871, 11431423 The TLR2/TLR6 complex is activated by LTA and diacylated lipoproteins, but not by triacylated lipoproteins while the TLR2/TLR1 complex is activated by triacylated lipoproteins, but not by diacylated lipoproteins.

Go back
573.0, 957.0
30.0, 30.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 17535871 Once activated the TIR domain of TLR2 engages with the TIR domain of MyD88 leading to the induction of ¡ÆMyD88-dependent¡Ç genes including TNFa.

Go back
757.0, 85.0
30.0, 30.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000041132 MO000041125

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c61 : 1

m6*m19005*m18998*0.1

nodelay

--

true

0

false

PMID: 17535871 Like Mal for MyD88, TRAM seems to link TRIF with the intracellular regions of TLR4.

Go back
69.0, 593.0
30.0, 30.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e23 e26 e28

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c50 : 1
stoichiometry:c53 : 1
stoichiometry:c59 : 1

m23*m26*m28*0.1

nodelay

--

true

0

false

PMID: 17535871, 11431423 The TLR2/TLR6 complex is activated by LTA and diacylated lipoproteins, but not by triacylated lipoproteins while the TLR2/TLR1 complex is activated by triacylated lipoproteins, but not by diacylated lipoproteins. PMID: 17535871 LTA from Gram-positive bacteria such as Staphylococcus aureus or diacylated lipoproteins are guided by CD36 to activate the TLR2/TLR6 complex.

Go back
493.0, 29.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 17535871, 2402637 LBP binds to the amphipathic lipid A moiety of LPS and facilitates its presentation and transfer to CD14.

Go back
685.0, 281.0
30.0, 30.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e18 MO000000213

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m18*m184*0.1

nodelay

--

true

0

false

PMID: 17535871 It involves early phase activation of NFkB via the IL-1R-associated kinase (IRAK) pathway.

Go back
681.0, 409.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000000212

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m32*m183*0.1

nodelay

--

true

0

false

PMID: 17535871 It involves early phase activation of NFkB via the IL-1R-associated kinase (IRAK) pathway.

Go back
657.0, 725.0
30.0, 30.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m34*m33*0.1

nodelay

--

true

0

false

PMID: 17535871 It involves early phase activation of NFkB via the IL-1R-associated kinase (IRAK) pathway.

Go back
621.0, 949.0
30.0, 30.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17535871 The TLR-IL-1 receptor (TIR) domains of TLR4 and TRIF or MyD88 are engaged and signalling occurs via the MyD88 or TRIF pathways leading to NOSII or TNF1 respectively.

Go back
681.0, 949.0
30.0, 30.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c78 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17535871 The TLR-IL-1 receptor (TIR) domains of TLR4 and TRIF or MyD88 are engaged and signalling occurs via the MyD88 or TRIF pathways leading to NOSII or TNF1 respectively.

Go back
521.0, 973.0
30.0, 30.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c74 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17535871 LPS induces a plethora of inflammatory and vasoactive genes, including nitric oxide synthase (NOS)II, cyclo-oxygenase-2, endothelin-1, TNF and other cytokines.

Go back
473.0, 1033.0
30.0, 30.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c75 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17535871 LPS induces a plethora of inflammatory and vasoactive genes, including nitric oxide synthase (NOS)II, cyclo-oxygenase-2, endothelin-1, TNF and other cytokines.

Go back
37.0, 689.0
30.0, 30.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e23 e38 e28

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m23*m39*m28*0.1

nodelay

--

true

0

false

PMID: 17535871, 15690042 for some ligands (LTA and R-MALP2), activation of the TLR2/TLR6 heterodimer is greatly facilitated by CD36.

Go back
925.0, 113.0
30.0, 30.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 MO000020434

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m41*m4923*0.1

nodelay

--

true

0

false

PMID: 17535871, 12796777, 12514169 NOD1 senses diaminopimelic acid (DAP)-containing PepG, which is mainly found in PepG of Gram-negative bacteria, while NOD2 senses the muramyl dipeptide (MDP) present in both Gram-positive and Gram-negative PepG.

Go back
989.0, 113.0
30.0, 30.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e40 MO000020461

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m41*m4947*0.1

nodelay

--

true

0

false

PMID: 17535871, 12796777, 12514169 NOD1 senses diaminopimelic acid (DAP)-containing PepG, which is mainly found in PepG of Gram-negative bacteria, while NOD2 senses the muramyl dipeptide (MDP) present in both Gram-positive and Gram-negative PepG.

Go back
557.0, 93.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021929 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6255*m5*0.1

nodelay

--

true

0

false

PMID: 17535871, 15596121, 16785880 It is believed that MD2 complexes with LPS (provided by CD14) and that the MD2?LPS complex, as apposed to LPS alone, is the ¡Ætrue ligand¡Ç for TLR4.

Go back
925.0, 341.0
30.0, 30.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000017949

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c95 : 1

m42*m2684*0.1

nodelay

--

true

0

false

PMID: 17535871 Both NOD1 and NOD2 signal via the adaptor protein RICK (also known as Rip2 or CARDIAK).

Go back
953.0, 269.0
30.0, 30.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000017949

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c94 : 1

m43*m2684*0.1

nodelay

--

true

0

false

PMID: 17535871 Both NOD1 and NOD2 signal via the adaptor protein RICK (also known as Rip2 or CARDIAK).

Go back
921.0, 405.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 MO000016828

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m45*m1765*0.1

nodelay

--

true

0

false

PMID: 17838971, 15952891, 17186029 The ensuing signalling cascade leads to activation of caspase-1 and the formation of IL-1b and IL-8.

Go back
749.0, 949.0
30.0, 30.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17838971, 15952891, 17186029 The ensuing signalling cascade leads to activation of caspase-1 and the formation of IL-1b and IL-8.

Go back
929.0, 1073.0
30.0, 30.0

p34

p34

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m93364*0.1

nodelay

--

true

0

false

PMID: 17838971, 15952891, 17186029 The ensuing signalling cascade leads to activation of caspase-1 and the formation of IL-1b and IL-8.

Go back
801.0, 977.0
30.0, 30.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17838971, 15952891, 17186029 The ensuing signalling cascade leads to activation of caspase-1 and the formation of IL-1b and IL-8.

Go back
917.0, 1009.0
30.0, 30.0

p36

p36

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e46

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 17838971, 15952891, 17186029 The ensuing signalling cascade leads to activation of caspase-1 and the formation of IL-1b and IL-8.

Go back
417.0, 925.0
30.0, 30.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041446

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR3 recruits TRIF.

Go back
325.0, 1065.0
30.0, 30.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e14

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c114 : 1

m1572*m14*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR7 and TLR8 recruits MyD88.

Go back
357.0, 1133.0
30.0, 30.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e15

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c115 : 1

m1572*m15*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR7 and TLR8 recruits MyD88.

Go back
169.0, 813.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17535871, 11489966, 11323673 TLR5 is a cell surface receptor activated by flagellin, a protein expressed on motile bacteria.

Go back
1149.0, 521.0
30.0, 30.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e63 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m64*m65*0.1

nodelay

--

true

0

false

PMID: 17535871, 15654120 Examples of endogenous ligands of TLRs are heat shock proteins, hyaluronic acid fragments, soluble heparan sulphate, fibrinogen extra domain A, oxidised LDL and b-defensin 2.

Go back
1149.0, 585.0
30.0, 30.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e63 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m64*m69*0.1

nodelay

--

true

0

false

PMID: 17535871, 15654120 Examples of endogenous ligands of TLRs are heat shock proteins, hyaluronic acid fragments, soluble heparan sulphate, fibrinogen extra domain A, oxidised LDL and b-defensin 2.

Go back
1141.0, 461.0
30.0, 30.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e66 e63

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c119 : 1
stoichiometry:c121 : 1

m67*m64*0.1

nodelay

--

true

0

false

PMID: 17535871, 15654120 Examples of endogenous ligands of TLRs are heat shock proteins, hyaluronic acid fragments, soluble heparan sulphate, fibrinogen extra domain A, oxidised LDL and b-defensin 2.

Go back
1149.0, 753.0
30.0, 30.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017426 e63

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m2254*m64*0.1

nodelay

--

true

0

false

PMID: 17535871, 15654120 Examples of endogenous ligands of TLRs are heat shock proteins, hyaluronic acid fragments, soluble heparan sulphate, fibrinogen extra domain A, oxidised LDL and b-defensin 2.

Go back
1149.0, 809.0
30.0, 30.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e63 MO000000290

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m64*m290118*0.1

nodelay

--

true

0

false

PMID: 17535871, 15654120 Examples of endogenous ligands of TLRs are heat shock proteins, hyaluronic acid fragments, soluble heparan sulphate, fibrinogen extra domain A, oxidised LDL and b-defensin 2.

Go back
1149.0, 697.0
30.0, 30.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e63 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m64*m73*0.1

nodelay

--

true

0

false

PMID: 17535871, 15654120 Examples of endogenous ligands of TLRs are heat shock proteins, hyaluronic acid fragments, soluble heparan sulphate, fibrinogen extra domain A, oxidised LDL and b-defensin 2.

Go back
369.0, 257.0
30.0, 30.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000019396

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m3964*m3963*0.1

nodelay

--

true

0

false

PMID: 17535871, 16880211, 11095740, 10549626 TLR2 is not thought to act as a monomeric receptor, but heterodimerises with either TLR1 or TLR6 to evoke effects.

Go back
181.0, 965.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR3 is an intracellular receptor which is activated by viral double-stranded RNA.

Go back
176.0, 1065.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000042126

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m13*m19940*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR7 and TLR8 are activated by single-stranded RNA from viruses.

Go back
176.0, 1197.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000042007

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m13*m19823*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR7 and TLR8 are activated by single-stranded RNA from viruses.

Go back
189.0, 1305.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e16 MO000042012

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m16*m19828*0.1

nodelay

--

true

0

false

PMID: 17535871, 11130078 TLR9 is activated by bacterial DNA, which because of its high level of unmethylated CpG dinucleotides is distinct from mammalian DNA.

Go back
623.0, 192.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e6 e11 MO000016573

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m6*m11*m1572*0.1

nodelay

--

true

0

false

PMID: 17535871 TLR4 is unique among the TLRs because it recruits both MyD88/Mal and TRIF/TRAM adaptor proteins.

Go back
395.0, 48.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
206.00462147221435, 788.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.2344920050584, 488.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
780.0, 1045.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.0, 1088.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.3595545008435, 488.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
830.0, 1007.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0, 1027.247700587784

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
947.0, 1024.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.90772170669385, 348.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 948.8649748931809

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.03225484557385, 903.8141043230231

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 825.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.3194710706861, 467.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.83623455111933, 467.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.0, 1080.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 1148.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.0, 1095.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.0, 1163.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.0, 557.157225063693

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 536.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 536.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.0, 498.13548692132855

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.0, 828.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.0, 476.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.9991090817946, 475.119389687788

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.0, 611.9267498715262

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 600.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.0, 600.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1187.0, 768.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1078.0, 672.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 768.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1077.0, 678.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 824.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 980.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 824.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.0, 664.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 712.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.0, 712.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 235.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.20633098764773, 236.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.1928741660319, 231.50179400188395

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
218.4477855878965, 934.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.0, 980.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
191.0, 1103.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.55385536415233, 1035.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
206.0, 1080.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
191.0, 1164.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.0, 63.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
214.0, 1212.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
206.0, 1164.9975603804353

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.0, 1268.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.91952058716754, 1277.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
219.0, 1320.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.0, 208.5321520841902

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.0, 220.07266324040117

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 228.2557859167673

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 203.72428596834015

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
161.0, 337.2089120009301

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
414.0, 67.39415491217066

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.27569820671823, 236.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.0, 316.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.0, 317.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.0, 320.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.2589500159179, 341.02855245727176

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.65685424949237, 335.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.3517178529796, 235.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.49063342055234, 268.80898753270714

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 65.03265276709044

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.9049919671384, 234.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 390.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.0, 448.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.13378106138947, 335.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.0, 448.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.8784275570199, 462.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.0, 448.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.96469174070592, 259.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
118.86600159651329, 219.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.0, 45.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
106.57079884854396, 615.5851508263321

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 547.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
142.48229005965027, 524.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
105.17297457938491, 625.0886525566467

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
285.0, 384.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
599.0, 987.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.0, 111.91400779426596

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 122.91487308291883

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0, 123.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.0, 609.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 67.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
84.00277739908026, 240.34381210396157

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 115.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 242.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
663.0, 296.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.0, 311.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.6379617782632, 384.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
654.0, 424.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.0, 439.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 696.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.3636881022716, 755.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 69.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.7636205865145, 506.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
636.0, 836.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
637.0, 979.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.1751242532865, 215.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 1003.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 1063.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.3857576427068, 248.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
490.81108561046074, 248.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
697.0, 979.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
199.07254492676245, 111.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 130.07934577905587

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
51.7331777394715, 232.39499030189927

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
74.59640676671205, 711.5089049871709

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
67.0, 706.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
75.0, 704.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
951.8102651883261, 89.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.0, 149.13406138394484

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 143.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 89.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 143.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1018.5455257366611, 149.58317520481958

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 123.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.1966833641114, 230.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.0, 284.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 230.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 303.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.0, 284.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.0, 356.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.1863898227368, 368.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.0, 420.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.0437687993774, 428.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.3897804297072, 979.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back