1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17544561.csml convertedTime:2009.07.01.11:05

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The role of type I interferon production by dendritic cells in host defense.
Authors Fitzgerald-Bocarsly P, Feng D.
Affiliation UMDNJ-New Jersey Medical School, 185 So. Orange Ave., Newark, NJ 07103, USA.bocarsly@umdnj.edu
Abstract Type I interferons (IFN) and dendritic cells (DC) share an overlapping history,with rapidly accumulating evidence for vital roles for both production of type 1IFN by DC and the interaction of this IFN both with DC and components of theinnate and adaptive immune responses. Within the innate immune response, theplasmacytoid DC (pDC) are the "professional" IFN producing cells, expressingspecialized toll-like receptors (TLR7 and -9) and high constitutive expressionof IRF-7 that allow them to respond to viruses with rapid and extremely robustIFN production; following activation and production of IFN, the pDC subsequentlymature into antigen presenting cells that help to shape the adaptive immuneresponse. However, like most cells in the body, the myeloid or conventional DC(mDC or cDC) also produce type I IFNs, albeit typically at a lower level thanthat observed with pDC, and this IFN is also important in innate and adaptiveimmunity induced by these classic antigen presenting cells. These two major DCsubsets and their IFN products interact both with each other as well as with NKcells, monocytes, T helper cells, T cytotoxic cells, T regulatory cells and Bcells to orchestrate the early immune response. This review discusses some ofthe converging history of DC and IFN as well as mechanisms for IFN induction inDC and the effects of this IFN on the developing immune response.
PMID 17544561
Model Abstract

Entity

G010693:Tlr4 G010713:IRF-7 MO000000212:TRAF6 MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016882:LPS MO000019394:TLR4 MO000019398:TLR3 MO000022224:dsRNA MO000039077:IRAK-4 MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042126:TLR7 MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e11: e12:ds DNA e13:TLR9:CpG DNA e14:CpG DNA e15:TLR9:ds DNA e16:Imidazoquinolones e17:TLR7:Imidazoquinolones e18:ssRNA e19:TLR7:ssRNA e2: e20:TLR9:CpG DNA:MyD88 e21:TLR7:ssRNA:MyD99 e22:IRAK-1 e23:TLR9:CpG DNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub} e24:TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6 e25:TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub} e26:TLR9:CpG DNA: MyD88:IRAK-1:IRAK-4:TRAF6 e27:TLR9:CpG DNA:MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7 e28:TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7 e29:TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7{p} e3: e30:TLR9:CpG DNA:MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7{p} e31:Type I IFN e32:dsRNA e33:DDX58:dsRNA e34:IFIH1:dsRNA e35:DDX58:dsRNA:MAVS e36:IFIH1:dsRNA:MAVS e37:DDX58:dsRNA:MAVS:TBK1:IKK-i e38:TBK1:IKK-i e39:DDX58:dsRNA:MAVS:TBK1:IKK-i e4: e40:IRF-3{p} e41:IRF-3{p} e42:Type I IFNs e43:IFNalpha/beta R e44:Type I IFNs e45:ISGF3 e46:ISGF3{active} e47:C-type lectin receptor e48:gD e49:gD:C-type Lectin receptor e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:gp120 e64:gp120:C-type Lectin receptor e65:IFN-alpha e66:Ligand:ILT7 e67:FcepsilonR1gamma e68:FcepsilonR1gamma e69:Cytokines e7: e70:IFN-alpha e71:IP-10 e72:Trail e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p5 p6 p7 p8 p9
Model Detail
673.0, 1257.0
30.0, 30.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
594.0, 1234.0
28.0, 28.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30 p35

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
856.0, 972.0
24.0, 24.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
352.0, 800.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
525.0, 813.0
22.0, 22.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1024.0, 840.0
23.0, 23.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1161.0, 1173.0
22.0, 22.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p30

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1092.0, 1260.0
24.0, 24.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

--

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
823.0, 375.0
17.0, 17.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
805.0, 149.0
22.0, 22.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
741.0, 977.0
21.5, 21.5

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
611.0, 275.0
18.0, 18.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
713.0, 401.0
22.0, 22.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
753.0, 373.0
22.0, 22.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
957.0, 445.0
21.5, 21.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
958.0, 554.0
19.0, 19.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
282.0, 366.0
20.0, 20.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
285.0, 421.0
21.0, 21.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
554.0, 294.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
149.75, 181.9969080091176
989.0765558849754, 1436.139159144984

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
167.0, 253.0
953.32479934837, 1341.0599324594382

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
705.0, 361.0
334.5634422467901, 558.5508315476073

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
1146.0, 449.5
60.0, 13.0

ds DNA

--

e12

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
989.5, 492.0
20.60776145582109, 39.88598991449244

TLR9:CpG DNA

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1154.0, 504.0
60.0, 16.0

CpG DNA

--

e14

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
918.5, 389.0
19.397939048454287, 37.54439815829863

TLR9:ds DNA

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1161.0, 549.0
53.5407905803196, 30.33978132884777

Imidazoquinolones

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1005.5, 612.0
21.008770006577503, 40.66213549660162

TLR7:Imidazoquinolones

--

e17

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p3

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1150.0, 632.5
60.0, 31.0

ssRNA

--

e18

cso30:c:Rna

cso30:i:CC_EndosomeLumen

--

--

p4

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
997.5, 668.0
20.621354966016224, 39.912299934224954

TLR7:ssRNA

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
149.75, 181.9969080091176
989.0765558849754, 1436.139159144984

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
887.5, 730.0
25.228665810240415, 35.20278950266104

TLR9:CpG DNA:MyD88

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p7

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
724.5, 499.0
23.674068636447053, 33.03358414387961

TLR7:ssRNA:MyD99

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p8

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
645.0, 921.0
21.5, 21.5

IRAK-1

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
734.0, 748.0
19.235294117647058, 32.05882352941176

TLR9:CpG DNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub}

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
734.0, 576.0
19.235294117647058, 32.05882352941176

TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
754.0, 636.0
19.235294117647058, 32.05882352941176

TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub}

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
734.0, 696.0
19.235294117647058, 32.05882352941176

TLR9:CpG DNA: MyD88:IRAK-1:IRAK-4:TRAF6

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
741.0, 798.0
21.97058823529412, 36.617647058823536

TLR9:CpG DNA:MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
798.0, 552.0
19.235294117647058, 32.05882352941176

TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
834.0, 896.0
19.235294117647058, 32.05882352941176

TLR7:ssRNA: MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7{p}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
169.53153111769944, 201.77843912681712
949.5134936495767, 1396.5760969095847

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
765.0, 846.0
21.97058823529412, 36.617647058823536

TLR9:CpG DNA:MyD88:IRAK-1:IRAK-4:TRAF6{ub}:IRF-7{p}

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
491.0, 1207.0
50.24221453287197, 26.795847750865054

Type I IFN

--

e31

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
425.0, 293.0
22.0, 22.0

dsRNA

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p19

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
394.5, 365.0
18.55974004332611, 22.726212297950347

DDX58:dsRNA

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
549.5, 375.0
21.37677053824363, 26.175637393767712

IFIH1:dsRNA

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
269.5, 533.0
21.40135804734814, 29.862360066067172

DDX58:dsRNA:MAVS

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
496.5, 477.0
22.111580106441547, 30.853367590383556

IFIH1:dsRNA:MAVS

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
270.0, 708.0
19.05882352941177, 31.764705882352946

DDX58:dsRNA:MAVS:TBK1:IKK-i

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
378.5, 596.0
19.359940009998333, 23.70604899183469

TBK1:IKK-i

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p23 p24

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
426.0, 668.0
19.05882352941177, 31.764705882352946

DDX58:dsRNA:MAVS:TBK1:IKK-i

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
206.12736368544364, 236.3961185827911
876.3218285140886, 1327.3407379976366

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
352.0, 884.0
24.0, 24.0

IRF-3{p}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
384.0, 1112.0
24.0, 24.0

IRF-3{p}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
101.0, 1126.5
29.849064198027776, 18.40692292211713

Type I IFNs

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
176.5, 1211.0
22.595782073813705, 34.76274165202109

IFNalpha/beta R

--

e43

cso30:c:Protein

cso30:i:CC_Nucleolus

--

--

p33

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
175.5, 1279.0
25.671344003508, 49.6864722648542

Type I IFNs

--

e44

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
255.0, 1362.5
25.919999999999998, 19.44

ISGF3

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
383.0, 1482.5
25.919999999999998, 19.44

ISGF3{active}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
717.5, 1564.0
20.72231985940246, 31.880492091388398

C-type lectin receptor

--

e47

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p36 p37

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
659.0, 1660.5
25.36928959549205, 15.644395250553432

gD

--

e48

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
502.5, 1553.0
19.656215742161805, 38.0442885332164

gD:C-type Lectin receptor

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
705.0, 361.0
334.5634422467901, 558.5508315476073

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
276.0, 996.0
512.137318329026, 464.45227937846573

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
331.3146451826508, 1007.0068438138605
299.46204460952373, 450.14676769329725

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
282.6759054530786, 1002.1990550635729
498.7855074228693, 452.0541692513196

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
283.6296062320897, 1003.152755842584
496.8781058648466, 450.14676769329725

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
276.0, 996.0
512.137318329026, 464.45227937846573

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
276.0, 996.0
512.137318329026, 464.45227937846573

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
283.6296062320897, 1003.152755842584
496.8781058648466, 450.14676769329725

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
649.8507053723986, 1186.7401558022443
31.995525708615602, 28.964370641483658

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
565.9250368194114, 1320.2582648638156
90.60157400606604, 82.01826699496522

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
276.0, 996.0
512.137318329026, 464.45227937846573

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
705.0, 361.0
334.5634422467901, 558.5508315476073

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
396.7078843318059, 1202.3987551550117
16.218636364737193, 7.808973064503105

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
396.16629815541387, 1179.110549570155
55.51258308018148, 99.92264954432675

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
419.45450374027087, 1244.100890737197
8.665378822272222, 8.665378822272231

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
827.5, 1651.0
16.024149728315557, 25.98510766753873

gp120

--

e63

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p37

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
890.5, 1557.0
19.656215742161805, 38.0442885332164

gp120:C-type Lectin receptor

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
484.0, 1274.0
39.34256055363321, 20.982698961937714

IFN-alpha

--

e65

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38 p39

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1086.5, 1042.0
18.616312212234156, 36.03157202367902

Ligand:ILT7

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
958.0, 1025.5
27.679999999999996, 20.76

FcepsilonR1gamma

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1088.5, 1119.0
23.674068636447053, 33.0335841438796

FcepsilonR1gamma

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
562.0, 1164.0
43.91003460207613, 23.418685121107266

Cytokines

--

e69

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p42

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
160.0, 188.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
113.0, 991.0
14.556594948550046, 33.59214218896164

IFN-alpha

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p43 p44

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
331.0, 1242.0
50.709342560553644, 27.04498269896194

IP-10

--

e71

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p43

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
426.0, 1320.0
43.0795847750865, 22.975778546712803

Trail

--

e72

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
163.0, 209.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
171.0, 230.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1054.0, 446.0
20.0, 20.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c6 : 1

m19828*m12*0.1

nodelay

--

true

0

false

PMID: 17544561,12900525,15272082,15345224,12470615,15113904,14976261,16224540,15034168 TLR9 is the receptor for both CpG sequences and double-stranded DNA from herpes simplex virus and cytomegalovirus, while the ligands for TLR7 include the imadazoquinolones and single stranded RNA such as found in viruses like HIV-1

Go back
626.0, 702.0
19.0, 19.0

p9

p10

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 17544561,16286015,15361868,15492225 This association, which requires that the TLR and ligand remain for an extended time in the endosome as opposed to being transferred to the lysosome for induction of IFN, also requires IRAK-4 and the ubiquitin ligase action of TRAF6 for the activation of IRF-7

Go back
602.0, 754.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m23*m980*0.1

nodelay

--

true

0

false

PMID: 17544561, 15815647 MyD88, which is required for signaling through TLR7 and TLR9, forms a complex with IRF-7 that is required for the signaling for type I IFN production in the pDC

Go back
798.0, 738.0
19.0, 19.0

p11

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m980*m25*0.1

nodelay

--

true

0

false

PMID: 17544561, 15815647 MyD88, which is required for signaling through TLR7 and TLR9, forms a complex with IRF-7 that is required for the signaling for type I IFN production in the pDC

Go back
890.0, 926.0
19.0, 19.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17544561, 15767370 A recent study demonstrated that the kinase that interacts with and phosphorylates the IRF-7 is IRAK-1; IRAK-1 deficient mice were found to be severely compromised in their ability to activate IRF-7 and induce type 1 IFN

Go back
818.0, 806.0
19.0, 19.0

p13

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17544561, 15767370 A recent study demonstrated that the kinase that interacts with and phosphorylates the IRF-7 is IRAK-1; IRAK-1 deficient mice were found to be severely compromised in their ability to activate IRF-7 and induce type 1 IFN

Go back
545.0, 1073.0
21.0, 21.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c108 : 1
stoichiometry:c44 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17544561, 15767370 A recent study demonstrated that the kinase that interacts with and phosphorylates the IRF-7 is IRAK-1; IRAK-1 deficient mice were found to be severely compromised in their ability to activate IRF-7 and induce type 1 IFN PMID: 17544561, 15815647 MyD88, which is required for signaling through TLR7 and TLR9, forms a complex with IRF-7 that is required for the signaling for type I IFN production in the pDC PMID: 17544561 These IFNs are translated, then secreted, and signal through the IFN-alpha/beta receptor and, through ISGF3 (comprised of STAT1, STAT2 and IRF-9), upregulate IRF-7 expression which is needed for the expression of the full range and magnitude of the IFN-alpha genes. PMID: 17544561 They further reported that cross-linking of this receptor on the pDC inhibits CpG and Flu-induced type I IFN and cytokine expression by these cells.

Go back
806.0, 302.0
19.0, 19.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17544561 cDC have an additional mechanism for the induction of type I IFN in response to dsRNA viruses that goes via the dsRNA sensor, TLR3 in the endosomes.

Go back
690.0, 326.0
19.0, 19.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 17544561,15711573 TLR3 signaling utilizes the adaptor molecule TRIF rather than the IPS-1/MAV5 used in the RIG-I/MDA-5 pathway

Go back
314.0, 294.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m32*m41844*0.1

nodelay

--

true

0

false

PMID: 17544561,16210631,15208624 dsRNA is well-known for its ability to activate PKR, but, more recently, the role for the retinoic acid-inducible gene-I (RIG-I) encoded helicases and melanoma differentiation-associated gene 5 (MDA-5) have been strongly implicated as the prevalent cytoplasmic receptors for dsRNA leading to IFN-alpha production

Go back
482.0, 342.0
19.0, 19.0

p18

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m76904*m32*0.1

nodelay

--

true

0

false

PMID: 17544561,16210631,15208624 dsRNA is well-known for its ability to activate PKR, but, more recently, the role for the retinoic acid-inducible gene-I (RIG-I) encoded helicases and melanoma differentiation-associated gene 5 (MDA-5) have been strongly implicated as the prevalent cytoplasmic receptors for dsRNA leading to IFN-alpha production

Go back
1058.0, 502.0
20.0, 20.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m14*m19828*0.1

nodelay

--

true

0

false

PMID: 17544561,12900525,15272082,15345224,12470615,15113904,14976261,16224540,15034168 TLR9 is the receptor for both CpG sequences and double-stranded DNA from herpes simplex virus and cytomegalovirus, while the ligands for TLR7 include the imadazoquinolones and single stranded RNA such as found in viruses like HIV-1

Go back
365.0, 477.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m68199*m33*0.1

nodelay

--

true

0

false

PMID: 17544561 Figure 1 PMID: 17544561, 15711573 TLR3 signaling utilizes the adaptor molecule TRIF rather than the IPS-1/MAV5 used in the RIG-I/MDA-5 pathway

Go back
461.0, 421.0
21.0, 21.0

p20

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m34*m68199*0.1

nodelay

--

true

0

false

PMID: 17544561 Figure 1 PMID: 17544561, 15711573 TLR3 signaling utilizes the adaptor molecule TRIF rather than the IPS-1/MAV5 used in the RIG-I/MDA-5 pathway

Go back
333.0, 669.0
5.0, 5.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

--

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0

1.0*0.1

nodelay

--

true

0

false

--

Go back
268.0, 616.0
23.0, 23.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c67 : 1

m38*m35*0.1

nodelay

--

true

0

false

PMID: 17544561 Figure 1

Go back
425.0, 537.0
21.0, 21.0

p23

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c68 : 1

m36*m38*0.1

nodelay

--

true

0

false

PMID: 17544561 Figure 1

Go back
270.0, 802.0
19.0, 19.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m37*m977*0.1

nodelay

--

true

0

false

PMID: 17544561 Figure 1

Go back
422.0, 758.0
19.0, 19.0

p25

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m39*m977*0.1

nodelay

--

true

0

false

PMID: 17544561 Figure 1

Go back
465.0, 1141.0
22.0, 22.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c76 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17544561 Figure 1 PMID: 17544561, 16210631, 15208624 dsRNA is well-known for its ability to activate PKR, but, more recently, the role for the retinoic acid-inducible gene-I (RIG-I) encoded helicases and melanoma differentiation-associated gene 5 (MDA-5) have been strongly implicated as the prevalent cytoplasmic receptors for dsRNA leading to IFN-alpha production PMID: 17544561 cDC have an additional mechanism for the induction of type I IFN in response to dsRNA viruses that goes via the dsRNA sensor, TLR3 in the endosomes

Go back
713.0, 1189.0
21.0, 21.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17544561,15265881 our group demonstrated that human peripheral blood pDC express basal levels of TLR4 and respond to LPS stimulation with upregulation of TLR4 message and protein as well as up-regulate the expression of the transcription factor, IRF-7

Go back
822.0, 1262.0
19.0, 19.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m93614*0.1

nodelay

--

true

0

false

PMID: 17544561,15265881 our group demonstrated that human peripheral blood pDC express basal levels of TLR4 and respond to LPS stimulation with upregulation of TLR4 message and protein as well as up-regulate the expression of the transcription factor, IRF-7

Go back
1066.0, 554.0
20.0, 20.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m19940*m16*0.1

nodelay

--

true

0

false

PMID: 17544561,12900525,15272082,15345224,12470615,15113904,14976261,16224540,15034168 TLR9 is the receptor for both CpG sequences and double-stranded DNA from herpes simplex virus and cytomegalovirus, while the ligands for TLR7 include the imadazoquinolones and single stranded RNA such as found in viruses like HIV-1

Go back
649.0, 1141.0
21.0, 21.0

p28

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17544561,15265881 our group demonstrated that human peripheral blood pDC express basal levels of TLR4 and respond to LPS stimulation with upregulation of TLR4 message and protein as well as up-regulate the expression of the transcription factor, IRF-7

Go back
394.0, 962.0
19.0, 19.0

p31

p31

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c83 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17544561 According to the classic pathway of type I IFN induction, virus stimulation leads to the phosphorylation of IRF-3, its translocation to the nucleus and subsequent upregulation of a subset of early type I IFN genes.

Go back
245.0, 1065.0
21.0, 21.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17544561 These IFNs are translated, then secreted, and signal through the IFN-alpha/beta receptor and, through ISGF3 (comprised of STAT1, STAT2 and IRF-9), upregulate IRF-7 expression which is needed for the expression of the full range and magnitude of the IFN-alpha genes.

Go back
97.0, 1225.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m42*m43*0.1

nodelay

--

true

0

false

PMID: 17544561 These IFNs are translated, then secreted, and signal through the IFN-alpha/beta receptor and, through ISGF3 (comprised of STAT1, STAT2 and IRF-9), upregulate IRF-7 expression which is needed for the expression of the full range and magnitude of the IFN-alpha genes.

Go back
257.0, 1441.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m44*m45*0.1

nodelay

--

true

0

false

PMID: 17544561 These IFNs are translated, then secreted, and signal through the IFN-alpha/beta receptor and, through ISGF3 (comprised of STAT1, STAT2 and IRF-9), upregulate IRF-7 expression which is needed for the expression of the full range and magnitude of the IFN-alpha genes.

Go back
452.0, 1376.0
23.0, 23.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17544561 These IFNs are translated, then secreted, and signal through the IFN-alpha/beta receptor and, through ISGF3 (comprised of STAT1, STAT2 and IRF-9), upregulate IRF-7 expression which is needed for the expression of the full range and magnitude of the IFN-alpha genes.

Go back
570.0, 1602.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m48*m47*0.1

nodelay

--

true

0

false

PMID: 17544561 Proposed candidate receptors for these viral glycoproteins are C-type lectin receptors.

Go back
786.0, 1602.0
19.0, 19.0

p36

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m47*m63*0.1

nodelay

--

true

0

false

PMID: 17544561 Proposed candidate receptors for these viral glycoproteins are C-type lectin receptors.

Go back
533.0, 1393.0
22.0, 22.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17544561,9837796,2999320,1850168,7526537, 7908920 In pDC, a requirement for viral envelope glycosylation in IFN-alpha induction, presumably by interaction of the glycoproteins with cell surface receptors, has been demonstrated. Examples of this include the requirement for gD, a glycoprotein of HSV-1 required for viral entry for induction of IFN-alpha in pDC and the mutation of a single amino acid in the M protein of porcine transmissible gastroenteritis virus that renders the virus non-interferogenic and the dependence on gp120 of HIV for IFN induction by pDC

Go back
637.0, 1369.0
22.0, 22.0

p38

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17544561,9837796,2999320,1850168,7526537, 7908920 In pDC, a requirement for viral envelope glycosylation in IFN-alpha induction, presumably by interaction of the glycoproteins with cell surface receptors, has been demonstrated. Examples of this include the requirement for gD, a glycoprotein of HSV-1 required for viral entry for induction of IFN-alpha in pDC and the mutation of a single amino acid in the M protein of porcine transmissible gastroenteritis virus that renders the virus non-interferogenic and the dependence on gp120 of HIV for IFN induction by pDC

Go back
1070.0, 638.0
20.0, 20.0

p1

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m18*m19940*0.1

nodelay

--

true

0

false

PMID: 17544561,12900525,15272082,15345224,12470615,15113904,14976261,16224540,15034168 TLR9 is the receptor for both CpG sequences and double-stranded DNA from herpes simplex virus and cytomegalovirus, while the ligands for TLR7 include the imadazoquinolones and single stranded RNA such as found in viruses like HIV-1

Go back
990.0, 1082.0
19.0, 19.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m67*m66*0.1

nodelay

--

true

0

false

PMID: 17544561,16735691 Cao et al. have recently described the expression of the ILT7 receptor on human pDC and demonstrated that it associates with the signal adapter protein Fc¦ÅR1¦Ã to form a receptor complex.

Go back
493.0, 1061.0
21.0, 21.0

p15

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17544561, 15767370 A recent study demonstrated that the kinase that interacts with and phosphorylates the IRF-7 is IRAK-1; IRAK-1 deficient mice were found to be severely compromised in their ability to activate IRF-7 and induce type 1 IFN PMID: 17544561, 15815647 MyD88, which is required for signaling through TLR7 and TLR9, forms a complex with IRF-7 that is required for the signaling for type I IFN production in the pDC

Go back
593.0, 1109.0
21.0, 21.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17544561 They further reported that cross-linking of this receptor on the pDC inhibits CpG and Flu-induced type I IFN and cytokine expression by these cells.

Go back
313.0, 1173.0
23.0, 23.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 17544561 In our study, we demonstrated that IFN-¦Á of PBMC can lead to direct upregulation of CXCL10 in pDC.

Go back
349.0, 1313.0
21.0, 21.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 17544561,17116765 Such activation of CD8+ cells is not always advantageous; for example, it has recently been demonstrated that pDC derived IFN-¦Á can stimulate cytotoxic T cell activity in atherosclerotic plaque through the induction of TRAIL

Go back
974.0, 738.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m13*m1572*0.1

nodelay

--

true

0

false

PMID: 17544561,15815647 MyD88, which is required for signaling through TLR7 and TLR9, forms a complex with IRF-7 that is required for the signaling for type I IFN production in the pDC

Go back
846.0, 678.0
19.0, 19.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m1572*m19*0.1

nodelay

--

true

0

false

PMID: 17544561,15815647 MyD88, which is required for signaling through TLR7 and TLR9, forms a complex with IRF-7 that is required for the signaling for type I IFN production in the pDC

Go back
894.0, 822.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m20*m183*m17258*m22*0.1

nodelay

--

true

0

false

PMID: 17544561,16286015,15361868,15492225 This association, which requires that the TLR and ligand remain for an extended time in the endosome as opposed to being transferred to the lysosome for induction of IFN, also requires IRAK-4 and the ubiquitin ligase action of TRAF6 for the activation of IRF-7 PMID: 17544561,15767370 A recent study demonstrated that the kinase that interacts with and phosphorylates the IRF-7 is IRAK-1; IRAK-1 deficient mice were found to be severely compromised in their ability to activate IRF-7 and induce type 1 IFN

Go back
642.0, 810.0
19.0, 19.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m22*m17258*m183*m21*0.1

nodelay

--

true

0

false

PMID: 17544561,16286015,15361868,15492225 This association, which requires that the TLR and ligand remain for an extended time in the endosome as opposed to being transferred to the lysosome for induction of IFN, also requires IRAK-4 and the ubiquitin ligase action of TRAF6 for the activation of IRF-7 PMID: 17544561,15767370 A recent study demonstrated that the kinase that interacts with and phosphorylates the IRF-7 is IRAK-1; IRAK-1 deficient mice were found to be severely compromised in their ability to activate IRF-7 and induce type 1 IFN

Go back
646.0, 582.0
19.0, 19.0

p9

p9

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 17544561,16286015,15361868,15492225 This association, which requires that the TLR and ligand remain for an extended time in the endosome as opposed to being transferred to the lysosome for induction of IFN, also requires IRAK-4 and the ubiquitin ligase action of TRAF6 for the activation of IRF-7

Go back
979.0, 456.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 648.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.0, 1581.6349772505464

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.0, 1422.8616846281632

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
510.48321425369073, 1302.604843651928

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.3206812385497, 1393.9039768230127

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.6564023547028, 1299.437601569802

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1046.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.5894663844041, 1063.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 1096.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
569.9818447596638, 1085.3806734951877

c108

c108

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
521.2436714876709, 917.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.0, 571.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 1082.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.4643249019568, 880.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
590.6625609418811, 1130.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.9977326771627, 1120.1346604691255

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
128.0, 1015.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
330.0, 1196.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.0, 1018.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
370.0, 1325.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1024.986910994626, 653.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
985.5424380787184, 532.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.5431001857819, 764.1726174492658

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.0, 748.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.9111023285845, 701.3906279097155

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.0, 688.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.5816675103376, 538.5580731030324

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.0, 765.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1082.0, 456.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 848.7849928783165

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 846.7406455330265

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 839.0048827077514

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.3612370850286, 771.1324413127782

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.3474977942104, 836.9924492668405

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0886031430172, 835.8762871041653

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.3724448104754, 831.83652221513

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.1354289315982, 532.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 615.4125320942628

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.0, 592.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.0, 512.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.0, 597.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.2033200579111, 719.4802557583166

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.0, 712.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.0, 764.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 776.9273757311803

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 767.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.0, 753.1490669328924

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.0, 668.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.0, 592.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 584.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.0, 462.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.3428562876811, 919.1752892054838

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.0, 816.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.8421713081511, 825.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.6568542494924, 875.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.2426094525969, 1094.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.7354436625493, 328.8094964814716

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 171.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.6380401729833, 321.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.0, 290.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
715.4, 347.8

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 512.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
703.0, 345.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.0, 304.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 320.2876334417754

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.0, 312.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.6757168780139, 311.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.0, 313.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 357.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
306.0, 439.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.9197461660486, 388.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.79428260231236, 495.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.5427214688052, 414.665961898457

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.1554175279993, 393.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 432.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.0, 442.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.87095928079924, 610.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 563.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.3548626638176, 501.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.0, 564.2790621242674

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 639.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 558.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 740.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.0, 564.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.0, 812.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 821.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.4132406834243, 700.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
376.0, 778.3701422443754

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.7612804888456, 777.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.0, 908.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 1163.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
741.9943896859761, 1184.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
699.5164229118466, 1210.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
703.0, 1272.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1094.0, 564.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
841.0, 1272.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.9851089399181, 1153.4878885299338

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.8102651883261, 1162.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.42687192428684, 981.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 1128.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
273.0005514799673, 1085.871986438035

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
138.34982135847048, 1081.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
109.59831958593307, 1145.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
125.958950698325, 1229.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
118.0, 1244.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.2494297193982, 574.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
201.0, 1328.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
268.0, 1382.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.0, 1455.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.0, 1405.6929482290266

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 1267.5593437103964

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.8428768595912, 1622.144277534682

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.8179574768908, 1582.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.9102312071875, 1582.0309682041927

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 1585.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.9251523357785, 1627.3041949897965

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back