1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17576036.csml convertedTime:2009.07.01.11:05

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Glucocorticoids and the innate immune system: crosstalk with the toll-likereceptor signaling network.
Authors Chinenov Y, Rogatsky I.
Affiliation Hospital for Special Surgery, Department of Microbiology & Immunology, WeillMedical College of Cornell University, 535 E70th Street, Research Building Room425, New York, NY 10021,USA.
Abstract Toll-like receptors (TLRs) are responsible for the recognition of a variety ofmicrobial pathogens and the initial induction of immune and inflammatoryresponses. These responses are normally restricted by the adrenally producedglucocorticoid hormones which provide a feedback mechanism to curb unabatedinflammation. Glucocorticoids act through a ligand-dependent transcriptionfactor-the glucocorticoid receptor (GR), which engages in a complex network ofprotein:protein and protein:DNA interactions ultimately activating or repressingtarget gene transcription. Not surprisingly, multiple mechanisms account for theglucocorticoid interference with TLR signaling including enhanced expression ofthe natural inhibitors of TLR pathways, direct repression of TLR-activatedtranscriptional regulators and cross-utilization of cofactors essential for bothGR and TLR signaling. Here we discuss recent and unexpected examples ofcrosstalk between the two transcriptional networks and the emerging role of GRin the regulation of innate immunity.
PMID 17576036
Model Abstract

Entity

G010228:IFN-beta G010241:osteocalcin G010262:IL-6 G010266:pro-opiomelanocortin G010329:TNF-alpha G010389:IL-1beta G010522:RANTES G010539:SOCS1 G010592:tyrosine hydroxylase G010657:IL-12 p40 G010693:Tlr4 G010909:IL18 G010962:TLR2 G011271:BCL2L1 G012572:SGK G026383:chromogranin A MO000000015:Raf-1 MO000000022:p38 MO000000023:JNK MO000000049:c-Jun MO000000058:NF-kappaB MO000000065:RIP1 MO000000212:TRAF6 MO000000215:IkappaB:NF-kappaB MO000000248:IKK MO000000276:AP-1 MO000000279:c-Fos MO000000286:E3s MO000000289:TNF-alpha MO000004272:E2F-1 MO000004670:ERK1 MO000004676:ERK2 MO000005192:Fli-1 MO000007685:IRF-1 MO000007690:IRF-2 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000011894:pRb MO000013122:STAT3 MO000016573:MyD88 MO000016574:TAK1 MO000016608:IKK-i MO000016656:STATs MO000016665:IFNgamma MO000016876:STAT5 MO000016917:MKK4 MO000016966:MKK3 MO000017004:SOCS-1 MO000017115:SOCS/CIS family MO000018808:MyoD MO000019005:MKK6 MO000019331:TBK1 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000021732:glucocorticoids MO000022224:dsRNA MO000022528:TIRAP MO000033624:SRC-1 MO000037106:Myogenin MO000038341:MKK4{p} MO000038355:MKK6{p} MO000038411:Raf-1{p} MO000038964:p160 MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000060849:PRMT1 MO000062794:Cocoa MO000062960:POMC MO000066783:osteocalcin MO000074564:GRIP1 MO000079932:BAF57 MO000086608:GAC63 e1: e10: e100:GILZ: Jun e101:GILZ: GILZ e102:GILZ e103:TLR2 ligand e104:TLR2 ligand: TLR2 e105:IL8 e106:TNF-alpha receptor e107:TNF-alpha: TNF-alpha receptor e108:IFN-gamma receptor e109:IFN-gamma: IFN-gamma receptor e11:GR: Hsp90: Hsp70 e110:IRF-1 {p} {nucleus} e111:p300:CBP e112:p300: CBP: IRF3 {p} : IRF3 e113:GRIP1: IRF3 {p} : IRF3 e114:IP-10 e115:p300:CBP: GRIP1 e116:IRF-1 {p} e117:casein kinase II e118:IRF3 {p} : IRF3: NF-kappaB e119:IRF-7 {activated} e12:glucocorticoids: GR: Hsp90: Hsp70 e120:IRF-7 {nucleus}} e121:p300: CBP: IRF-7{nucleus} e122:p300:CBP: IRF-2 e123:p300:CBP: IRF-1{p} {nucleus} e124:p300: CBP: IRF-5 e13:glucocorticoids: GR: Hsp90: Hsp70 {nucleus} e14:simple GRE e15:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: simple GRE e16:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: NF-kappaB e17:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: STAT5 e18:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: STAT3 e19:AF-2 e2: e20:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: AF-2 e21:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: SRC-1 e22:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: GRIP1 e23:glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: SRC-3 e24:SRC-3 e25:p160: Fli-1 e26:p160: Cocoa e27:p160: GAC63 e28:p160: BAF57 e3: e30:p160: CBP: p300 e31:p160: CRAM1 e32:p160: MEF2c e33:p160: PRMT1 e34:p160: Myogenin e35:p160: pCAF e36:p160: pRb e37:p160: E2F1 e38:p160: MyoD e39:p160: NF-kappaB e4: e40:pCAF e41:CRAM1 e42:MEF2C e43:p160: STATs e44:p160: IRFs e45:IRFs e46:TLR ligand e47:TLR ligand : TLR e48:TLR ligand : TLR: TLR e49:TLR ligand : TLR: TLR: TIRAP: MyD88 e5:GILZ e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:GILZ: NF-kappaB e60: e61: e62: e63:IRAK1 e64:TLR ligand : TLR: TLR: TIRAP: MyD88: IRAK-4: IRAK1 e65:TLR ligand : TLR: TLR: TIRAP: MyD88: IRAK-4: IRAK1 {p} e66:TLR ligand : TLR: TLR: TRIF: TRAM e67:IRAK1 {p} e68:IRAK1 {p}: TRAF6 e69:IRAK1{p}: TRAF6 {p} e7: e70:IRAK1{p}: TRAF6 {p}: TAK1 e71:IRAK1{p}: TRAF6 {p}: TAK1 {p} e72:IKK {p} e73:MKK3 {p} e74:JNK {p} e75:p38 {p} e76:IkappaB {p}:NF-kappaB e77:IkappaB remnants e78:NF-kappaB {cytoplasm} e79:AP-1 {activated} e8: e80:dsRNA:TLR3: TRIF e81:dsRNA:TLR3: TRIF: IRF3: IKK-i: TBK1 e82:IRF3 {p} e83:dsRNA:TLR3: TRIF: IKK-i: TBK1 e84:IRF3 {p} : IRF3 e85:IRF3 {p} : IRF3 e86:dsRNA:TLR3: TRIF: RIP1 e87:MKP e88:TIRAp ramnents e89:TIRAP {ub} e9: e90:Jak e91:SOCS/CIS family: Jak e92:STATs {cytoplasm} e93:STATs {cytoplasm}: Jak e94:Jak {ub} e95:Jak remnants e96:GILZ: Raf-1 e97:ERK2 {activated} e98:ERK1 {activated} e99:GILZ: Fos

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
618.0, 1212.0
27.5, 27.5

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p102

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
958.0, 1264.0
27.0, 27.0

osteocalcin

--

G010241

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p7

true true true true

csml-variable:Double

m93229

10

false

infinite

0

unit false false false
TRANSFACG010241

--

Go back
746.0, 1316.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p87 p92 p93 p97

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
969.0, 1229.0
30.0, 30.0

pro-opiomelanocortin

--

G010266

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m93252

10

false

infinite

0

unit false false false
TRANSFACG010266

--

Go back
879.0, 1277.0
26.0, 26.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p84

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
790.0, 1308.0
28.0, 28.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p86

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
619.0, 1289.0
25.0, 25.0

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p104

--

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
1000.0, 872.0
24.0, 24.0

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p68

--

true true true true

csml-variable:Double

m93501

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
968.0, 1178.0
24.0, 24.0

tyrosine hydroxylase

--

G010592

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p5

--

true true true true

csml-variable:Double

m93546

10

false

infinite

0

unit false false false
TRANSFACG010592

--

Go back
728.0, 1124.0
24.0, 24.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p89

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
834.0, 1018.0
28.0, 28.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p90

--

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
831.0, 1277.0
26.0, 26.0

IL18

--

G010909

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p85

--

true true true true

csml-variable:Double

m93795

10

false

infinite

0

unit false false false
TRANSFACG010909

--

Go back
921.0, 1279.0
22.0, 22.0

TLR2

--

G010962

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p71 p116

p83

true true true true

csml-variable:Double

m93848

10

false

infinite

0

unit false false false
TRANSFACG010962

--

Go back
516.0, 1306.0
24.0, 24.0

BCL2L1

--

G011271

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p72

--

true true true true

csml-variable:Double

m94156

10

false

infinite

0

unit false false false
TRANSFACG011271

--

Go back
944.0, 1142.0
24.5, 24.5

SGK

--

G012572

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p4

--

true true true true

csml-variable:Double

m95292

10

false

infinite

0

unit false false false
TRANSFACG012572

--

Go back
1009.0, 1195.0
29.0, 29.0

chromogranin A

--

G026383

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m105086

10

false

infinite

0

unit false false false
TRANSFACG026383

--

Go back
356.0, 1494.0
30.0, 30.0

Raf-1

--

MO000000015

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74 p75

true true true true

csml-variable:Double

m101

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000015

--

Go back
667.0, 639.0
25.0, 25.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

p48

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
452.0, 654.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59

p47

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
424.0, 1542.0
30.0, 30.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p79

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
873.0, 789.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p115

p9 p28 p71 p108

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
311.0, 445.0
24.0, 24.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
442.0, 262.0
30.0, 30.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
731.0, 371.0
28.0, 28.0

IkappaB:NF-kappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
564.0, 408.0
26.0, 26.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
796.0, 592.0
32.0, 32.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
552.0, 1510.0
30.0, 30.0

c-Fos

--

MO000000279

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m221

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
903.0, 337.0
31.0, 31.0

E3s

--

MO000000286

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m227

10

false

infinite

0

unit false false false
TRANSPATHMO000000286

--

Go back
738.0, 1684.0
26.0, 26.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p94

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
508.0, 1090.0
24.0, 24.0

E2F-1

--

MO000004272

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m481

10

false

infinite

0

unit false false false
InterProIPR003316
TRANSPATHMO000004272

--

Go back
399.0, 1341.0
32.0, 32.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
298.0, 1500.0
28.0, 28.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
527.0, 791.0
27.0, 27.0

Fli-1

--

MO000005192

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m631

10

false

infinite

0

unit false false false
TRANSPATHMO000005192

--

Go back
974.0, 398.0
28.0, 28.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p107

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
738.0, 998.0
28.0, 28.0

IRF-2

--

MO000007690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p113

true true true true

csml-variable:Double

m974

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007690

--

Go back
344.0, 638.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p106

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
777.0, 1005.0
30.0, 30.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p114

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
931.0, 615.0
26.0, 26.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p109

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
548.0, 1078.0
24.0, 24.0

pRb

--

MO000011894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m1320

10

false

infinite

0

unit false false false
InterProIPR006670
TRANSPATHMO000011894

--

Go back
935.0, 907.0
25.5, 25.5

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
541.0, 235.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
619.0, 363.0
36.0, 36.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
342.0, 544.0
26.0, 26.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
440.0, 1122.0
24.0, 24.0

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
830.0, 1684.0
26.0, 26.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p96

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
931.0, 867.0
26.0, 26.0

STAT5

--

MO000016876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1798

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
449.0, 547.0
28.0, 28.0

MKK4

--

MO000016917

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61

p45

true true true true

csml-variable:Double

m1832

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
442.0, 474.0
28.0, 28.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

p44

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
685.0, 211.0
28.0, 28.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
793.0, 195.0
28.0, 28.0

SOCS/CIS family

--

MO000017115

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

p64

true true true true

csml-variable:Double

m2002

10

false

infinite

0

unit false false false
TRANSPATHMO000017115

--

Go back
472.0, 1110.0
32.0, 32.0

MyoD

--

MO000018808

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m3431

10

false

infinite

0

unit false false false
InterProIPR001092
TRANSPATHMO000018808

--

Go back
447.0, 589.0
32.0, 32.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

p46

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
345.0, 595.0
28.0, 28.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
640.0, 144.0
25.0, 25.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
969.0, 1583.0
28.0, 28.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

p82

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
212.0, 466.0
24.0, 24.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1067.0, 731.0
26.0, 26.0

glucocorticoids

--

MO000021732

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p47 p48

true true true true

csml-variable:Double

m6069

10

false

infinite

0

unit false false false
TRANSPATHMO000021732

--

Go back
98.0, 464.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
619.0, 233.0
24.0, 24.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p67

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
923.0, 987.0
26.0, 26.0

SRC-1

--

MO000033624

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m12297

10

false

infinite

0

unit false false false
InterProIPR001092
TRANSPATHMO000033624

--

Go back
578.0, 1060.0
28.0, 28.0

Myogenin

--

MO000037106

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m15404

10

false

infinite

0

unit false false false
InterProIPR001092
TRANSPATHMO000037106

--

Go back
601.0, 545.0
30.0, 30.0

MKK4{p}

--

MO000038341

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

p46 p61

true true true true

csml-variable:Double

m16555

10

false

infinite

0

unit false false false
TRANSPATHMO000038341

--

Go back
606.0, 590.0
28.0, 28.0

MKK6{p}

--

MO000038355

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p47 p48 p60

true true true true

csml-variable:Double

m16567

10

false

infinite

0

unit false false false
TRANSPATHMO000038355

--

Go back
457.0, 1395.0
28.0, 28.0

Raf-1{p}

--

MO000038411

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

p76

true true true true

csml-variable:Double

m16621

10

false

infinite

0

unit false false false
TRANSPATHMO000038411

--

Go back
426.0, 920.0
28.0, 28.0

p160

--

MO000038964

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17 p18 p19 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p30 p31

true true true true

csml-variable:Double

m17147

10

false

infinite

0

unit false false false
TRANSPATHMO000038964

--

Go back
474.0, 214.0
22.0, 22.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
307.0, 247.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p53

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
314.0, 306.0
29.0, 29.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
209.0, 509.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p53

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
627.0, 987.0
25.0, 25.0

PRMT1

--

MO000060849

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m35749

10

false

infinite

0

unit false false false
TRANSPATHMO000060849

--

Go back
592.0, 824.0
26.0, 26.0

Cocoa

--

MO000062794

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m37680

10

false

infinite

0

unit false false false
TRANSPATHMO000062794

--

Go back
1114.0, 1166.0
36.0, 36.0

POMC

--

MO000062960

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

--

true true true true

csml-variable:Double

m37845

10

false

infinite

0

unit false false false
TRANSPATHMO000062960

--

Go back
1102.0, 1306.0
28.0, 28.0

osteocalcin

--

MO000066783

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m41640

10

false

infinite

0

unit false false false
TRANSPATHMO000066783

--

Go back
879.0, 1127.0
34.0, 34.0

GRIP1

--

MO000074564

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p101 p105

true true true true

csml-variable:Double

m49366

10

false

infinite

0

unit false false false
TRANSPATHMO000074564

--

Go back
648.0, 880.0
24.0, 24.0

BAF57

--

MO000079932

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m54408

10

false

infinite

0

unit false false false
TRANSPATHMO000079932

--

Go back
624.0, 848.0
24.0, 24.0

GAC63

--

MO000086608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m60467

10

false

infinite

0

unit false false false
TRANSPATHMO000086608

--

Go back
172.0628412906976, 131.15386205440558
1060.2012312269626, 1537.9058940609182

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
160.11027278574377, 154.6600415263124
1022.8271882994276, 1437.4223750774047

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
473.625, 1540.5
27.670179970005, 33.88185302449592

GILZ: Jun

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
619.5, 1433.125
31.240000000000002, 23.429999999999996

GILZ: GILZ

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

p80

p73

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
812.0, 1060.0
32.0, 32.0

GILZ

--

e102

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p81

p117

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
TRANSPATHG023909

--

Go back
901.5, 1677.375
35.087873462214404, 22.807117750439364

TLR2 ligand

--

e103

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p82

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
916.625, 1586.5
29.499208465255787, 36.12147975337444

TLR2 ligand: TLR2

--

e104

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p82

p84 p85 p86 p87 p88 p91 p92 p93 p95 p97 p98

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
683.0, 1301.0
26.0, 26.0

IL8

--

e105

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p88 p91 p95 p98

--

true true true true

csml-variable:Double

m111

10

false

infinite

0

unit false false false
Affymetrix1369_s_at
EnsemblENSG00000169429
HGNCIL8
OMIM146930
ProteomeHumanPSD/IL8
RefSeqNM_000584
TRANSFACG000317
UnigeneHs.551925

--

Go back
688.5, 1625.0
20.7908611599297, 31.985940246045686

TNF-alpha receptor

--

e106

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p94

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
724.5, 1613.0
23.6730980048235, 45.81889936417452

TNF-alpha: TNF-alpha receptor

--

e107

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p94

p91 p92

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
777.5, 1601.0
26.04569420035149, 40.070298769771526

IFN-gamma receptor

--

e108

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p96

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
822.5, 1593.0
24.699408024556018, 47.80530585397939

IFN-gamma: IFN-gamma receptor

--

e109

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p96

p93 p95

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
1116.5, 798.0
31.81005689117269, 44.38612589465957

GR: Hsp90: Hsp70

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
850.0, 858.5
36.480000000000004, 27.360000000000003

IRF-1 {p} {nucleus}

--

e110

cso30:c:Protein

cso30:i:CC_Cytosol

--

p99

p112

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
638.5, 1143.0
27.843692717880348, 34.094317613731036

p300:CBP

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p20 p100 p105 p111 p112 p113 p114

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
521.5, 1252.0
28.164250321159845, 39.29895393650211

p300: CBP: IRF3 {p} : IRF3

--

e112

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p100

p102 p103 p104

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
736.5, 1258.0
22.593401099816703, 27.665389101816366

GRIP1: IRF3 {p} : IRF3

--

e113

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p101

p14

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
618.0, 1248.0
28.0, 28.0

IP-10

--

e114

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p103

--

true true true true

csml-variable:Double

m120

10

false

infinite

0

unit false false false
Affymetrix1418930_at
EnsemblENSMUSG00000034855
MGDCxcl10
ProteomeHumanPSD/Cxcl10
RefSeqNM_021274
TRANSFACG001062
UnigeneMm.263514

--

Go back
794.5, 1234.0
26.120813197800363, 31.98466922179637

p300:CBP: GRIP1

--

e115

cso30:c:Complex

cso30:i:CC_Nucleolus

--

p105

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
970.0, 518.5
36.480000000000004, 27.360000000000003

IRF-1 {p}

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

p107

p99

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
1060.0, 459.5
40.98208895149929, 25.272288186757898

casein kinase II

--

e117

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p107

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
737.25, 773.0
22.31280968985135, 31.134153055606532

IRF3 {p} : IRF3: NF-kappaB

--

e118

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p108

--

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
935.0, 651.0
26.0, 26.0

IRF-7 {activated}

--

e119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p109

p110

true true true true

csml-variable:Double

m125

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1095.875, 869.5
32.25, 45.0

glucocorticoids: GR: Hsp90: Hsp70

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
727.0, 927.0
26.0, 26.0

IRF-7 {nucleus}}

--

e120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p110

p111

true true true true

csml-variable:Double

m126

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
771.75, 905.0
24.5, 30.0

p300: CBP: IRF-7{nucleus}

--

e121

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p111

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
751.75, 961.0
24.5, 30.0

p300:CBP: IRF-2

--

e122

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p113

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
819.75, 865.0
24.5, 30.0

p300:CBP: IRF-1{p} {nucleus}

--

e123

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p112

--

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
847.75, 913.0
24.5, 30.0

p300: CBP: IRF-5

--

e124

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p114

--

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
1043.875, 977.5
32.25, 45.0

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3 p9 p10 p11 p12 p13 p14 p15 p68 p81 p84 p89 p90 p97 p98 p102 p103 p104 p116

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1048.5, 1038.125
31.08, 23.30999999999999

simple GRE

--

e14

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1043.875, 1077.5
32.25, 45.0

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: simple GRE

--

e15

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p3

p4 p5 p6 p7 p8

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
942.5, 817.0
27.809139291613135, 38.803450174343915

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: NF-kappaB

--

e16

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p9

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
913.25, 849.0
21.5, 30.0

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: STAT5

--

e17

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p10

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
905.25, 904.0
22.31280968985135, 31.134153055606532

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: STAT3

--

e18

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p11

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
927.0, 943.0
26.0, 26.0

AF-2

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSFACT00014
TRANSPATHMO000024643

--

Go back
172.0628412906976, 131.15386205440558
1060.2012312269626, 1537.9058940609182

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
893.25, 957.0
21.5, 30.0

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: AF-2

--

e20

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p12

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
905.25, 1017.0
21.5, 30.0

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: SRC-1

--

e21

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p13

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
785.25, 1137.0
21.5, 30.0

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: GRIP1

--

e22

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p14

p101

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
865.25, 1203.0
21.5, 30.0

glucocorticoids: GR: Hsp90: Hsp70 {nucleus}: SRC-3

--

e23

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p15

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
899.0, 1165.0
26.0, 26.0

SRC-3

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
Affymetrix207700_s_at
EnsemblENSG00000124151
HGNCNCOA3
OMIM601937
ProteomeHumanPSD/NCOA3
RefSeqNM_006534
TRANSPATHMO000088113
UnigeneHs.592142
UniProtQ9Y6Q9-2

--

Go back
581.25, 785.0
21.5, 30.0

p160: Fli-1

--

e25

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p16

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
625.25, 789.0
21.5, 30.0

p160: Cocoa

--

e26

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p17

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
669.25, 805.0
21.5, 30.0

p160: GAC63

--

e27

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p18

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
689.25, 845.0
21.5, 30.0

p160: BAF57

--

e28

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p19

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
193.2668659152368, 152.33713883210424
1017.7931819778834, 1495.5393405055227

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
703.75, 901.0
24.5, 30.0

p160: CBP: p300

--

e30

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p20

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
675.75, 977.0
24.5, 30.0

p160: CRAM1

--

e31

cso30:c:Complex

cso30:i:CC_NuclearChromosome

--

p22

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
639.75, 1077.0
24.5, 30.0

p160: MEF2c

--

e32

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p24

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
643.75, 1025.0
24.5, 30.0

p160: PRMT1

--

e33

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p23

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
591.75, 1101.0
24.5, 30.0

p160: Myogenin

--

e34

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p25

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
675.75, 929.0
24.5, 30.0

p160: pCAF

--

e35

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
555.75, 1125.0
24.5, 30.0

p160: pRb

--

e36

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p26

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
519.75, 1155.0
24.5, 30.0

p160: E2F1

--

e37

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p27

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
463.75, 1167.0
24.5, 30.0

p160: MyoD

--

e38

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p29

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
374.75, 1054.0
24.5, 30.0

p160: NF-kappaB

--

e39

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p28

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
232.49431147063467, 189.40787319307657
939.3382908670887, 1421.3978717835769

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
616.0, 914.75
24.080000000000002, 18.06

pCAF

--

e40

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p21

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
630.0, 957.75
27.439999999999998, 20.58

CRAM1

--

e41

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p22

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
596.0, 1024.0
24.0, 24.0

MEF2C

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
Affymetrix104591_g_at
EnsemblENSMUSG00000005583
MGD5430401D19Rik
ProteomeHumanPSD/Mef2c
RefSeqNM_025282
TRANSFACT09547
TRANSPATHMO000056814
UnigeneMm.207461
UniProtQ8CFN5

--

Go back
419.75, 1159.0
24.5, 30.0

p160: STATs

--

e43

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
383.75, 1123.0
24.5, 30.0

p160: IRFs

--

e44

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p31

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
403.0, 1089.0
26.0, 26.0

IRFs

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
698.0, 68.5
35.571177504393674, 23.121265377855885

TLR ligand

--

e46

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p32

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
604.75, 138.0
24.5, 30.0

TLR ligand : TLR

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p33

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
544.75, 130.0
24.5, 30.0

TLR ligand : TLR: TLR

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

p34 p35 p71

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
490.25, 118.0
25.4930262433474, 35.57166452560102

TLR ligand : TLR: TLR: TIRAP: MyD88

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p34

p36

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
510.0, 1392.0
26.0, 26.0

GILZ

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

p117

p71 p72 p75 p78 p79 p80 p116

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
Affymetrix207001_x_at
EnsemblENSG00000157514
HGNCTSC22D3
OMIM300506
ProteomeHumanPSD/TSC22D3
RefSeqNM_001015881
TRANSPATHMO000085795
UnigeneHs.133473
UniProtQ99576-1

--

Go back
355.6170401722165, 743.6447518183568
750.8013591632066, 680.2280967198622

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
436.709179523177, 759.7651688145111
439.0160647620982, 659.2765126319817

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
365.40402250767727, 752.7237715897726
731.2273944922854, 662.0700571770329

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
366.8021628413144, 754.1205438622975
728.4311138250104, 659.2765126319817

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
355.6170401722165, 743.6447518183568
750.8013591632066, 680.2280967198622

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
355.6170401722165, 743.6447518183568
750.8013591632066, 680.2280967198622

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
366.8021628413144, 754.1205438622975
728.4311138250104, 659.2765126319817

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
903.6880509580208, 1022.9992063234336
46.90594363939052, 42.42067396140464

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
780.6517015979417, 1218.5473244769864
132.8233316955393, 120.12241543718324

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
355.6170401722165, 743.6447518183568
750.8013591632066, 680.2280967198622

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
620.625, 1543.5
28.870479920013334, 35.351608065322445

GILZ: NF-kappaB

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p73

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
532.5766960585133, 1045.9324972296276
23.776775857984425, 11.43687547860037

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
531.782722210511, 1011.8250281432313
81.38231942020629, 146.34483828931056

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
565.9235976745985, 1107.008662802946
12.703581568032176, 12.691151287961889

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
427.0, 215.0
20.0, 20.0

IRAK1

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000046974

--

Go back
417.25, 108.0
30.772343549275096, 42.938153789686176

TLR ligand : TLR: TLR: TIRAP: MyD88: IRAK-4: IRAK1

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36 p38

p37

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
340.25, 99.0
30.709212699577904, 42.850064231969164

TLR ligand : TLR: TLR: TIRAP: MyD88: IRAK-4: IRAK1 {p}

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

p38

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
197.25, 355.0
21.5, 30.0

TLR ligand : TLR: TLR: TRIF: TRAM

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p55

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
342.0, 217.75
30.0, 22.5

IRAK1 {p}

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p38

p39 p109

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
443.5, 309.0
26.529078486918856, 32.484585902349615

IRAK1 {p}: TRAF6

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
560.75, 310.0
24.5, 30.0

IRAK1{p}: TRAF6 {p}

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
221.9923390772691, 135.3425169484916
1009.896503971246, 1429.5970490764635

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
504.75, 366.0
24.5, 30.0

IRAK1{p}: TRAF6 {p}: TAK1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
441.25, 416.0
30.504037438062028, 42.563773169388874

IRAK1{p}: TRAF6 {p}: TAK1 {p}

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p43 p44

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
666.0, 429.75
30.0, 22.5

IKK {p}

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

p43

p49

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
601.0, 476.75
30.0, 22.5

MKK3 {p}

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

p44

p45 p62

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
456.0, 713.75
30.0, 22.5

JNK {p}

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

p47

p59

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
729.0, 592.75
30.0, 22.5

p38 {p}

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

p48

p51 p63

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
664.0, 477.5
30.080000000000002, 22.56

IkappaB {p}:NF-kappaB

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p49

p50

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
788.0, 474.0
30.103388856978754, 29.099942561746126

IkappaB remnants

--

e77

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
736.0, 526.0
30.0, 30.0

NF-kappaB {cytoplasm}

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p73 p115

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
800.0, 660.0
32.0, 32.0

AP-1 {activated}

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

--

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
225.7068718203548, 161.31880381522268
997.4225995844488, 1446.8405144137298

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
195.5, 571.0
33.18315287208662, 46.30207377500459

dsRNA:TLR3: TRIF

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p53

p54 p58

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
378.5, 670.0
43.0, 60.0

dsRNA:TLR3: TRIF: IRF3: IKK-i: TBK1

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p55

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
288.5, 826.125
31.560000000000006, 23.669999999999995

IRF3 {p}

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

p55 p106

p56

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
375.875, 763.5
32.25, 45.0

dsRNA:TLR3: TRIF: IKK-i: TBK1

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
300.5, 958.125
31.400000000000006, 23.549999999999997

IRF3 {p} : IRF3

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
432.5, 1210.125
31.400000000000006, 23.549999999999997

IRF3 {p} : IRF3

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

p57

p100 p101 p108

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
358.875, 474.5
32.25, 45.0

dsRNA:TLR3: TRIF: RIP1

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
609.0, 693.0
30.0, 30.0

MKP

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p60 p61 p62 p63

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR000340
TRANSPATHMO000016814

--

Go back
744.5, 327.25
28.664560597357838, 27.709075244112583

TIRAp ramnents

--

e88

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p66

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
685.5, 283.125
27.4, 20.549999999999997

TIRAP {ub}

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

p67

p66

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
235.61229246858352, 187.2950906819538
992.8688182967451, 1427.8655636126234

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
841.0, 211.0
28.0, 28.0

Jak

--

e90

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64 p65

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
842.625, 264.5
33.01845525745709, 40.43076153974337

SOCS/CIS family: Jak

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65 p69

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
955.0, 213.0
24.0, 24.0

STATs {cytoplasm}

--

e92

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
904.625, 295.5
27.768163639393432, 34.001833027828695

STATs {cytoplasm}: Jak

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
843.5, 394.125
30.12, 22.59

Jak {ub}

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

p69

p70

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
844.5, 515.25
28.59563469270534, 27.642446869615167

Jak remnants

--

e95

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p70

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
426.625, 1497.5
24.95929845025829, 30.56240626562239

GILZ: Raf-1

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

p76 p77

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
330.0, 1448.0
28.0, 28.0

ERK2 {activated}

--

e97

cso30:c:Protein

cso30:i:CC_CellComponent

--

p77

--

true true true true

csml-variable:Double

m102

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
351.0, 1397.0
32.0, 32.0

ERK1 {activated}

--

e98

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

p77

true true true true

csml-variable:Double

m103

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
513.625, 1512.5
27.580361606398935, 33.771871354774206

GILZ: Fos

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1066.0, 810.0
27.0, 27.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021732 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6069*m11*0.1

nodelay

--

true

0

false

PMID: 17576036, 10099820 In its inactive state, GR resides in the cytoplasm as a part of a large multiprotein complex containing heat shock proteins (hsp90, hsp70), co-chaperones and immunofillins. Ligand binding induces a series of conformational changes in the receptor that result in rearrangement of this complex, exposure of the GR nuclear localization signal and rapid nuclear translocation.

Go back
973.0, 913.0
21.0, 21.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e13 MO000016876

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m13*m1798*0.1

nodelay

--

true

0

false

PMID: 17576036, 2169352, 10995388, 9388192 Tethering GREs do not contain bona fide DNA recognition sequence for GR, but rather a binding site for another transcription factor which recruits GR through protein:protein interactions. Binding to tethering GREs often requires neither GR DNA binding activity nor its dimerization. Several transcription factors, including AP1, NFkappaB, Stat3 and Stat5 can provide a ¡Ètether¡É for GR.

Go back
455.5, 1261.5
17.0, 17.0

p100

p100

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e85 e111

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c285 : 1
stoichiometry:c286 : 1

m88*m117*0.1

nodelay

--

true

0

false

PMID: 17576036, 16932750 This phosphorylation is required for nuclear translocation of IRF3 as well as binding of CBP/p300, the best known IRF3 coactivators.

Go back
724.5, 1190.5
23.0, 23.0

p101

p101

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000074564 e85 e22

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c288 : 1
stoichiometry:c291 : 1
stoichiometry:c289 : 1

m49366*m88*0.1

nodelay

--

true

0

false

PMID: 17576036 GR and IRF3 hinder each other's binding to GRIP1 in vitro suggesting that interacting surfaces may partially overlap precluding GR and IRF3 from binding GRIP1 at the same time. PMID: 17576036 both GRIP1 and IRF3 are conventional interacting partners for CBP/p300, their interaction with each other is CBP-independent.

Go back
565.5, 1219.5
21.0, 21.0

p102

p102

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e112 e13

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c296 : 1
stoichiometry:c292 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 17576036 glucocorticoids strongly inhibited dsRNA-induced expression of multiple cytokines and chemokines including interferon beta, IP10 and RANTES, known transcriptional targets of IRF3.

Go back
574.5, 1252.5
19.0, 19.0

p103

p103

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e112 e13

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c294 : 1
stoichiometry:c297 : 1
stoichiometry:c299 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 17576036 glucocorticoids strongly inhibited dsRNA-induced expression of multiple cytokines and chemokines including interferon beta, IP10 and RANTES, known transcriptional targets of IRF3.

Go back
578.5, 1296.5
19.0, 19.0

p104

p104

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e112 e13

G010522

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c298 : 1
stoichiometry:c300 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 17576036 glucocorticoids strongly inhibited dsRNA-induced expression of multiple cytokines and chemokines including interferon beta, IP10 and RANTES, known transcriptional targets of IRF3.

Go back
820.5, 1198.5
23.0, 23.0

p105

p105

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000074564 e111

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c302 : 1
stoichiometry:c303 : 1

m49366*m117*0.1

nodelay

--

true

0

false

PMID: 17576036 both GRIP1 and IRF3 are conventional interacting partners for CBP/p300, their interaction with each other is CBP-independent.

Go back
275.5, 759.5
25.0, 25.0

p106

p106

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c304 : 1
stoichiometry:c305 : 1

m977*0.1

nodelay

--

true

0

false

PMID: 17576036 TLR4 is the main LPS sensor that can activate IRF3 through both MyD88- and TRIF-dependent pathways.

Go back
975.5, 459.5
25.0, 25.0

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007685 e117

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c306 : 1
stoichiometry:c307 : 1
stoichiometry:c308 : 1

m970*m123*0.1

nodelay

--

true

0

false

PMID: 17576036, 10094406 casein kinase II-dependent phosphorylation of IRF1 is required for its full transactivation.

Go back
765.0, 745.0
21.0, 21.0

p108

p108

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e85 MO000000058

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1

m88*m16*0.1

nodelay

--

true

0

false

PMID: 17576036, 16143103 because both GR and IRF3 appear to interact with the Rel domain of p65, IRF3 and GR were proposed to compete for the same binding site on NFkappaB.

Go back
989.0, 613.0
30.0, 30.0

p109

p109

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e67

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c315 : 1
stoichiometry:c314 : 1

m980*m68*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175 IRAK4/1 initiate signaling cascades that lead to the activation of NFkappaB, AP1 and possibly IRF7 and IRF5.

Go back
976.0, 940.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e13 MO000013122

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m13*m1360*0.1

nodelay

--

true

0

false

PMID: 17576036, 2169352, 10995388, 9388192 Tethering GREs do not contain bona fide DNA recognition sequence for GR, but rather a binding site for another transcription factor which recruits GR through protein:protein interactions. Binding to tethering GREs often requires neither GR DNA binding activity nor its dimerization. Several transcription factors, including AP1, NFkappaB, Stat3 and Stat5 can provide a ¡Ètether¡É for GR.

Go back
831.0, 727.0
25.0, 25.0

p110

p110

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e119

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c317 : 1
stoichiometry:c318 : 1

m125*0.1

nodelay

--

true

0

false

PMID: 17576036 Several IRFs, including IRF1, 2, 3, 5 and 7 interact with CBP/p300 coactivators through the C-terminal IAD domain.

Go back
668.5, 1056.5
15.0, 15.0

p111

p111

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e111 e120

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c321 : 1
stoichiometry:c323 : 1
stoichiometry:c327 : 1

m117*m126*0.1

nodelay

--

true

0

false

PMID: 17576036 Several IRFs, including IRF1, 2, 3, 5 and 7 interact with CBP/p300 coactivators through the C-terminal IAD domain.

Go back
724.5, 1056.5
15.0, 15.0

p112

p112

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e111 e110

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c325 : 1
stoichiometry:c329 : 1

m117*m116*0.1

nodelay

--

true

0

false

PMID: 17576036 Several IRFs, including IRF1, 2, 3, 5 and 7 interact with CBP/p300 coactivators through the C-terminal IAD domain.

Go back
704.5, 1036.5
15.0, 15.0

p113

p113

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e111 MO000007690

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c324 : 1
stoichiometry:c328 : 1

m117*m974*0.1

nodelay

--

true

0

false

PMID: 17576036 Several IRFs, including IRF1, 2, 3, 5 and 7 interact with CBP/p300 coactivators through the C-terminal IAD domain.

Go back
764.5, 1072.5
15.0, 15.0

p114

p114

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e111 MO000007700

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c320 : 1
stoichiometry:c326 : 1
stoichiometry:c330 : 1

m117*m979*0.1

nodelay

--

true

0

false

PMID: 17576036 Several IRFs, including IRF1, 2, 3, 5 and 7 interact with CBP/p300 coactivators through the C-terminal IAD domain.

Go back
835.0, 687.0
25.0, 25.0

p99

p115

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e78

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c331 : 1
stoichiometry:c332 : 1

m81*0.1

nodelay

--

true

0

false

--

Go back
930.0, 1198.0
19.0, 19.0

p71

p116

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13 e5

G010962

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c333 : 1
stoichiometry:c335 : 1
stoichiometry:c334 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175, 9430225, 17208592 Glucocorticoid-inducible leucine zipper (GILZ) is a small protein with a wide spectrum of anti-inflammatory activities including inhibition of LPS-induced expression of TLR2 in macrophages and of TLR 2- and 3-mediated NFkappaB activation in airway epithelial cells; inhibition of dendritic cells¡Ç maturation, and enhancement of spontaneous thymocyte apoptosis, likely through downregulation of the anti-apoptotic factor Bcl-X. PMID: 17576036 In HeLa cervical carcinoma cells, the basal TLR2 expression is low but is induced upon exposure to lipoprotein from the Gram-negative bacterium Haemophilus influenzae and further potentiated by glucocorticoids. PMID: 17576036,16765091 in dendritic cells, glucocorticoids augment the expression of both TLR2 and TLR4, but inhibit the production of proinflammatory cytokines TNF-alpha and IL-12 in response to TLR agonists, suggesting that TLR2 signaling is blocked downstream of the receptor and that a mere increase in the amount of TLR2 does not relieve this block.

Go back
469.0, 1341.0
30.0, 30.0

p117

p117

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e102

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c336 : 1
stoichiometry:c256 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175, 9430225, 17208592 Glucocorticoid-inducible leucine zipper (GILZ) is a small protein with a wide spectrum of anti-inflammatory activities including inhibition of LPS-induced expression of TLR2 in macrophages and of TLR 2- and 3-mediated NFkappaB activation in airway epithelial cells; inhibition of dendritic cells¡Ç maturation, and enhancement of spontaneous thymocyte apoptosis, likely through downregulation of the anti-apoptotic factor Bcl-X.

Go back
976.0, 968.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m13*m20*0.1

nodelay

--

true

0

false

PMID: 17576036, 16751179, 15957004, 12215713 the best understood interaction is that between the GR AF2 and the p160 family members: SRC1, SRC2/GRIP1/TIF2 and SRC3/AIB1/ACTR/Rac3.

Go back
972.0, 1000.0
23.0, 23.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e13 MO000033624

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m13*m12297*0.1

nodelay

--

true

0

false

PMID: 17576036, 16751179, 15957004, 12215713 the best understood interaction is that between the GR AF2 and the p160 family members: SRC1, SRC2/GRIP1/TIF2 and SRC3/AIB1/ACTR/Rac3.

Go back
920.0, 1072.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e13 MO000074564 e113

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c290 : 1
stoichiometry:c38 : 1

m13*m49366*0.1

nodelay

--

true

0

false

PMID: 17576036, 16751179, 15957004, 12215713 the best understood interaction is that between the GR AF2 and the p160 family members: SRC1, SRC2/GRIP1/TIF2 and SRC3/AIB1/ACTR/Rac3. PMID: 17576036 GR and IRF3 hinder each other's binding to GRIP1 in vitro suggesting that interacting surfaces may partially overlap precluding GR and IRF3 from binding GRIP1 at the same time.

Go back
937.0, 1099.0
21.0, 21.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e13 e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m13*m25*0.1

nodelay

--

true

0

false

PMID: 17576036, 16751179, 15957004, 12215713 the best understood interaction is that between the GR AF2 and the p160 family members: SRC1, SRC2/GRIP1/TIF2 and SRC3/AIB1/ACTR/Rac3.

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461.0, 855.0
22.0, 22.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000005192 MO000038964

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c50 : 1

m631*m17147*0.1

nodelay

--

true

0

false

PMID: 17576036, 14966289, 14690606, 15988012 Although no DNA binding activity has been reported for p160 cofactors, bHLH/PAS domain reportedly binds several secondary coactivators such as flightless I, CoCoA, GAC63 and a component of SWI/SNF chromatin remodeling complex, BAF57.

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491.0, 855.0
17.0, 17.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000062794 MO000038964

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c51 : 1

m37680*m17147*0.1

nodelay

--

true

0

false

PMID: 17576036, 14966289, 14690606, 15988012 Although no DNA binding activity has been reported for p160 cofactors, bHLH/PAS domain reportedly binds several secondary coactivators such as flightless I, CoCoA, GAC63 and a component of SWI/SNF chromatin remodeling complex, BAF57.

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521.0, 865.0
15.0, 15.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000086608 MO000038964

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c52 : 1

m60467*m17147*0.1

nodelay

--

true

0

false

PMID: 17576036, 14966289, 14690606, 15988012 Although no DNA binding activity has been reported for p160 cofactors, bHLH/PAS domain reportedly binds several secondary coactivators such as flightless I, CoCoA, GAC63 and a component of SWI/SNF chromatin remodeling complex, BAF57.

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531.0, 879.0
17.0, 17.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000079932 MO000038964

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c53 : 1

m54408*m17147*0.1

nodelay

--

true

0

false

PMID: 17576036, 14966289, 14690606, 15988012 Although no DNA binding activity has been reported for p160 cofactors, bHLH/PAS domain reportedly binds several secondary coactivators such as flightless I, CoCoA, GAC63 and a component of SWI/SNF chromatin remodeling complex, BAF57.

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1079.0, 973.0
25.0, 25.0

p2

p2

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 17576036, 10099820 In its inactive state, GR resides in the cytoplasm as a part of a large multiprotein complex containing heat shock proteins (hsp90, hsp70), co-chaperones and immunofillins. Ligand binding induces a series of conformational changes in the receptor that result in rearrangement of this complex, exposure of the GR nuclear localization signal and rapid nuclear translocation.

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543.0, 899.0
18.0, 18.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 e111

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c337 : 1
stoichiometry:c56 : 1

m17147*m117*0.1

nodelay

--

true

0

false

PMID: 17576036, 9430642, 11997499, 15731352 The C-terminal half of p160s houses activation domains (AD) 1 and 2 which recruit histone acetyl transferases (CBP/p300 and pCAF) and arginine methyl transferases (CARM1 and PRMT1), respectively.

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548.5, 920.5
15.0, 15.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 e40

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c73 : 1
stoichiometry:c57 : 1

m17147*m41*0.1

nodelay

--

true

0

false

PMID: 17576036, 9430642, 11997499, 15731352 The C-terminal half of p160s houses activation domains (AD) 1 and 2 which recruit histone acetyl transferases (CBP/p300 and pCAF) and arginine methyl transferases (CARM1 and PRMT1), respectively.

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548.5, 940.5
15.0, 15.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 e41

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c74 : 1
stoichiometry:c58 : 1

m17147*m42*0.1

nodelay

--

true

0

false

PMID: 17576036, 9430642, 11997499, 15731352 The C-terminal half of p160s houses activation domains (AD) 1 and 2 which recruit histone acetyl transferases (CBP/p300 and pCAF) and arginine methyl transferases (CARM1 and PRMT1), respectively.

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536.5, 960.5
15.0, 15.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 MO000060849

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c76 : 1
stoichiometry:c59 : 1

m17147*m35749*0.1

nodelay

--

true

0

false

PMID: 17576036, 9430642, 11997499, 15731352 The C-terminal half of p160s houses activation domains (AD) 1 and 2 which recruit histone acetyl transferases (CBP/p300 and pCAF) and arginine methyl transferases (CARM1 and PRMT1), respectively.

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524.5, 980.5
15.0, 15.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 e42

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c77 : 1
stoichiometry:c60 : 1

m17147*m43*0.1

nodelay

--

true

0

false

Go back
512.5, 1000.5
15.0, 15.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 MO000037106

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c78 : 1
stoichiometry:c61 : 1

m17147*m15404*0.1

nodelay

--

true

0

false

PMID: 17576036, 10817756, 15767262, 15169882 Historically identified as nuclear receptor coactivators, individual p160s are emerging as cofactors for a variety of non-receptor transcriptional regulators including MEF2C and myogenin, pRb, E2F1, MyoD, NFkappaB, STATs and most recently, IRFs.

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496.5, 1020.5
15.0, 15.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 MO000011894

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c79 : 1
stoichiometry:c62 : 1

m17147*m1320*0.1

nodelay

--

true

0

false

PMID: 17576036, 10817756, 15767262, 15169882 Historically identified as nuclear receptor coactivators, individual p160s are emerging as cofactors for a variety of non-receptor transcriptional regulators including MEF2C and myogenin, pRb, E2F1, MyoD, NFkappaB, STATs and most recently, IRFs.

Go back
476.5, 1032.5
15.0, 15.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 MO000004272

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c82 : 1
stoichiometry:c63 : 1

m17147*m481*0.1

nodelay

--

true

0

false

PMID: 17576036, 10817756, 15767262, 15169882 Historically identified as nuclear receptor coactivators, individual p160s are emerging as cofactors for a variety of non-receptor transcriptional regulators including MEF2C and myogenin, pRb, E2F1, MyoD, NFkappaB, STATs and most recently, IRFs.

Go back
383.5, 1009.5
15.0, 15.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 MO000000058

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c75 : 1
stoichiometry:c64 : 1

m17147*m16*0.1

nodelay

--

true

0

false

PMID: 17576036, 10817756, 15767262, 15169882 Historically identified as nuclear receptor coactivators, individual p160s are emerging as cofactors for a variety of non-receptor transcriptional regulators including MEF2C and myogenin, pRb, E2F1, MyoD, NFkappaB, STATs and most recently, IRFs.

Go back
452.5, 1032.5
15.0, 15.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 MO000018808

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c83 : 1
stoichiometry:c81 : 1

m17147*m3431*0.1

nodelay

--

true

0

false

PMID: 17576036, 10817756, 15767262, 15169882 Historically identified as nuclear receptor coactivators, individual p160s are emerging as cofactors for a variety of non-receptor transcriptional regulators including MEF2C and myogenin, pRb, E2F1, MyoD, NFkappaB, STATs and most recently, IRFs.

Go back
995.0, 1077.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e14 e13

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m14*m13*0.1

nodelay

--

true

0

false

PMID: 17576036 Simple GREs contain a specific DNA sequence to which GR binds as a sole regulator, typically as a homodimer. PMID: 17576036, 17559307, 9582068 GREs have been proposed to serve as the second ¡Æallosteric ligand¡Ç for the receptor.

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428.5, 1024.5
15.0, 15.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 MO000016656

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m17147*m1633*0.1

nodelay

--

true

0

false

PMID: 17576036, 10817756, 15767262, 15169882 Historically identified as nuclear receptor coactivators, individual p160s are emerging as cofactors for a variety of non-receptor transcriptional regulators including MEF2C and myogenin, pRb, E2F1, MyoD, NFkappaB, STATs and most recently, IRFs.

Go back
404.5, 1016.5
15.0, 15.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000038964 e45

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m17147*m46*0.1

nodelay

--

true

0

false

PMID: 17576036, 10817756, 15767262, 15169882 Historically identified as nuclear receptor coactivators, individual p160s are emerging as cofactors for a variety of non-receptor transcriptional regulators including MEF2C and myogenin, pRb, E2F1, MyoD, NFkappaB, STATs and most recently, IRFs.

Go back
640.0, 68.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 MO000019395

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m47*m3962*0.1

nodelay

--

true

0

false

PMID: 17576036 Ligand-dependent homo- or heterodimerization of TLRs brings two TIR domains in close proximity allowing for the recruitment of additional adaptor molecules.

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603.0, 187.0
27.0, 27.0

p33

p33

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17576036 Ligand-dependent homo- or heterodimerization of TLRs brings two TIR domains in close proximity allowing for the recruitment of additional adaptor molecules.

Go back
547.0, 187.0
22.0, 22.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000022528 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m1572*m6810*m49*0.1

nodelay

--

true

0

false

PMID: 17576036 Upon interaction with PAMPs, TLRs recruit adaptor proteins MyD88 and TRIF/TICAM1, which transmit signal to downstream kinases as well as ubuiquitin ligases involved in degradation of inhibitors of NFkappaB. PMID: 17576036 Two additional adaptor proteins, TIRAP and TRAM, likely facilitate the recruitment of MyD88 and TRIF to specific TLRs.

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259.0, 309.0
23.0, 23.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 MO000041132 MO000041125

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c108 : 1

m49*m19005*m18998*0.1

nodelay

--

true

0

false

PMID: 17576036 Upon interaction with PAMPs, TLRs recruit adaptor proteins MyD88 and TRIF/TICAM1, which transmit signal to downstream kinases as well as ubuiquitin ligases involved in degradation of inhibitors of NFkappaB. PMID: 17576036 Two additional adaptor proteins, TIRAP and TRAM, likely facilitate the recruitment of MyD88 and TRIF to specific TLRs.

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461.0, 157.0
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

MO000039077 e63 e49

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m17258*m64*m63*0.1

nodelay

--

true

0

false

PMID: 17576036 MyD88 contains two protein:protein interaction domains: the C-terminal TIR domain interacts with TIR domain of TLRs and IL-1R, while the N-terminal death domain binds the death domain-containing protein kinases, such as the IL-1R-associated kinase 4 (IRAK4), which phosphorylate another kinase, IRAK1.

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392.0, 168.0
25.0, 25.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17576036 MyD88 contains two protein:protein interaction domains: the C-terminal TIR domain interacts with TIR domain of TLRs and IL-1R, while the N-terminal death domain binds the death domain-containing protein kinases, such as the IL-1R-associated kinase 4 (IRAK4), which phosphorylate another kinase, IRAK1.

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344.0, 172.0
25.0, 25.0

p38

p38

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e65

e64 e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 17576036 The latter binds to and phosphorylates TRAF6, a ubiquitin ligase that targets TGF-activated kinase (TAK)1.

Go back
384.0, 240.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 MO000000212

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m68*m183*0.1

nodelay

--

true

0

false

PMID: 17576036 The latter binds to and phosphorylates TRAF6, a ubiquitin ligase that targets TGF-activated kinase (TAK)1.

Go back
981.0, 1107.0
21.0, 21.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G012572

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c12 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17576036, 8455596, 2884660, 2038339 Depending on promoter organization, simple GREs could confer either activation (sgk1; tyrosine hydroxylase; chromogranin A) or repression of transcription.

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505.0, 313.0
23.0, 23.0

p40

p40

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17576036 The latter binds to and phosphorylates TRAF6, a ubiquitin ligase that targets TGF-activated kinase (TAK)1.

Go back
562.0, 370.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000016574

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m70*m1573*0.1

nodelay

--

true

0

false

PMID: 17576036 The latter binds to and phosphorylates TRAF6, a ubiquitin ligase that targets TGF-activated kinase (TAK)1.

Go back
443.0, 367.0
27.0, 27.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 17576036 The latter binds to and phosphorylates TRAF6, a ubiquitin ligase that targets TGF-activated kinase (TAK)1.

Go back
505.0, 429.0
23.0, 23.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e71 MO000000248

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m72*m207*0.1

nodelay

--

true

0

false

PMID: 17576036, 16186825, 16260493 Activated TAK1 in turn initiates a cascade of phosphorylation events ultimately inducing the IkappaB kinase (IKK) and the MKK3,4,6/JNK/p38 pathways.

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523.0, 475.0
26.0, 26.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e71 MO000016966

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m72*m1875*0.1

nodelay

--

true

0

false

PMID: 17576036, 16186825, 16260493 Activated TAK1 in turn initiates a cascade of phosphorylation events ultimately inducing the IkappaB kinase (IKK) and the MKK3,4,6/JNK/p38 pathways.

Go back
524.0, 548.0
23.0, 23.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016917 e73

MO000038341

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c130 : 1
stoichiometry:c129 : 1

m1832*m74*0.1

nodelay

--

true

0

false

PMID: 17576036, 16186825, 16260493 Activated TAK1 in turn initiates a cascade of phosphorylation events ultimately inducing the IkappaB kinase (IKK) and the MKK3,4,6/JNK/p38 pathways.

Go back
523.0, 607.0
25.0, 25.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000019005 MO000038341

MO000038355

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c131 : 1
stoichiometry:c133 : 1

m3613*m16555*0.1

nodelay

--

true

0

false

PMID: 17576036, 16186825, 16260493 Activated TAK1 in turn initiates a cascade of phosphorylation events ultimately inducing the IkappaB kinase (IKK) and the MKK3,4,6/JNK/p38 pathways.

Go back
528.0, 676.0
23.0, 23.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000023 MO000038355 MO000021732

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c134 : 1
stoichiometry:c184 : 1
stoichiometry:c136 : 1

m75*m16567*0.1

nodelay

--

true

0

false

PMID: 17576036, 16186825, 16260493 Activated TAK1 in turn initiates a cascade of phosphorylation events ultimately inducing the IkappaB kinase (IKK) and the MKK3,4,6/JNK/p38 pathways. PMID: 17576036, 9407028, 9794429 glucocorticoids inhibit several TLR-activated protein kinases including JNK and p38 without altering their levels, suggesting that GR does not repress transcription of JNK or p38.

Go back
671.0, 591.0
25.0, 25.0

p48

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 MO000038355 MO000021732

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c137 : 1
stoichiometry:c185 : 1
stoichiometry:c139 : 1

m77*m16567*0.1

nodelay

--

true

0

false

PMID: 17576036, 16186825, 16260493 Activated TAK1 in turn initiates a cascade of phosphorylation events ultimately inducing the IkappaB kinase (IKK) and the MKK3,4,6/JNK/p38 pathways. PMID: 17576036, 9407028, 9794429 glucocorticoids inhibit several TLR-activated protein kinases including JNK and p38 without altering their levels, suggesting that GR does not repress transcription of JNK or p38.

Go back
735.0, 425.0
23.0, 23.0

p49

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000215 e72

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c141 : 1

m186*m73*0.1

nodelay

--

true

0

false

PMID: 17576036 The former activates transcription factor NFkappaB through the phosphorylation and degradation of its inhibitor, IkappaB, while the latter is involved in numerous stress-related pathways including activation of transcription factors from the AP1 family.

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997.0, 1135.0
21.0, 21.0

p5

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G010592

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c13 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17576036, 8455596, 2884660, 2038339 Depending on promoter organization, simple GREs could confer either activation (sgk1; tyrosine hydroxylase; chromogranin A) or repression of transcription.

Go back
738.0, 476.0
25.0, 25.0

p50

p50

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e76

e77 e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 17576036 The former activates transcription factor NFkappaB through the phosphorylation and degradation of its inhibitor, IkappaB, while the latter is involved in numerous stress-related pathways including activation of transcription factors from the AP1 family.

Go back
732.0, 664.0
23.0, 23.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e75

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c146 : 1
stoichiometry:c148 : 1

m219*m78*0.1

nodelay

--

true

0

false

PMID: 17576036 The former activates transcription factor NFkappaB through the phosphorylation and degradation of its inhibitor, IkappaB, while the latter is involved in numerous stress-related pathways including activation of transcription factors from the AP1 family.

Go back
147.0, 465.0
25.0, 25.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17576036, 16720699 In TLR3, two positively charged patches (patch1 and patch2) were proposed to be involved in interaction with dsRNA as substitution of either of these patches with alanines abolishes TLR3 signaling.

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132.0, 534.0
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 MO000041446

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c55 : 1
stoichiometry:c153 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 17576036, 12471095 TLR3 is the only TLR which does not interact with MyD88 and utilizes another TIR-domain adaptor, TRIF.

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266.0, 640.0
25.0, 25.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e80 MO000016608 MO000019331 MO000007694

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m83*m1599*m3902*m977*0.1

nodelay

--

true

0

false

PMID: 17576036, 16822173, 12692549 The N-terminal domain of TRIF interacts with IRF3 and several kinases including IKK-related TBK1 and IKKepsilon.

Go back
328.0, 776.0
23.0, 23.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e81 e66

e82 e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c309 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m84*m67*0.1

nodelay

--

true

0

false

PMID: 17576036 TBK1/IKKepsilon phosphorylate IRF3 and possibly IRF7 leading to dimerization and nuclear translocation of these transcription factors.

Go back
306.0, 896.0
19.0, 19.0

p56

p56

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e82

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17576036 TBK1/IKKepsilon phosphorylate IRF3 and possibly IRF7 leading to dimerization and nuclear translocation of these transcription factors.

Go back
301.0, 1207.0
30.0, 30.0

p57

p57

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 17576036 TBK1/IKKepsilon phosphorylate IRF3 and possibly IRF7 leading to dimerization and nuclear translocation of these transcription factors.

Go back
311.0, 497.0
23.0, 23.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 e80

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m89*m83*0.1

nodelay

--

true

0

false

PMID: 17576036 The C-terminal domain of TRIF interacts with protein kinase RIP1.

Go back
529.0, 713.0
21.0, 21.0

p59

p59

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e74 e87

MO000000023

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c182 : 1
stoichiometry:c176 : 1

m76*m91*0.1

nodelay

--

true

0

false

PMID: 17576036, 17073741 Negative regulation of these pathways involves dephosphorylation of JNK, p38 and their upstream kinases MEK3,4,6 by MAPK phosphatases (MKPs, also known as DUSPs).

Go back
1032.0, 1146.0
23.0, 23.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G026383

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c14 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17576036, 8455596, 2884660, 2038339 Depending on promoter organization, simple GREs could confer either activation (sgk1; tyrosine hydroxylase; chromogranin A) or repression of transcription.

Go back
524.0, 640.0
23.0, 23.0

p60

p60

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

MO000038355 e87

MO000019005

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c181 : 1
stoichiometry:c174 : 1

m16567*m91*0.1

nodelay

--

true

0

false

PMID: 17576036, 17073741 Negative regulation of these pathways involves dephosphorylation of JNK, p38 and their upstream kinases MEK3,4,6 by MAPK phosphatases (MKPs, also known as DUSPs).

Go back
527.0, 579.0
18.0, 18.0

p61

p61

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

MO000038341 e87

MO000016917

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c180 : 1
stoichiometry:c172 : 1

m16555*m91*0.1

nodelay

--

true

0

false

PMID: 17576036, 17073741 Negative regulation of these pathways involves dephosphorylation of JNK, p38 and their upstream kinases MEK3,4,6 by MAPK phosphatases (MKPs, also known as DUSPs).

Go back
525.0, 509.0
21.0, 21.0

p62

p62

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e73 e87

MO000016966

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c179 : 1
stoichiometry:c170 : 1

m74*m91*0.1

nodelay

--

true

0

false

PMID: 17576036, 17073741 Negative regulation of these pathways involves dephosphorylation of JNK, p38 and their upstream kinases MEK3,4,6 by MAPK phosphatases (MKPs, also known as DUSPs).

Go back
612.0, 640.0
23.0, 23.0

p63

p63

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e75 e87

MO000000022

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c183 : 1
stoichiometry:c178 : 1

m78*m91*0.1

nodelay

--

true

0

false

PMID: 17576036, 17073741 Negative regulation of these pathways involves dephosphorylation of JNK, p38 and their upstream kinases MEK3,4,6 by MAPK phosphatases (MKPs, also known as DUSPs).

Go back
795.0, 273.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017115 e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m2002*m94*0.1

nodelay

--

true

0

false

PMID: 17576036, 15032587 These proteins contain SH2 domains which physically interact with JAKs competitively blocking their interaction with STATs as well as serve as adapters for E3 ubiquitin ligases which target JAKs for degradation.

Go back
907.0, 249.0
23.0, 23.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e90 e92 e91

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c198 : 1
stoichiometry:c197 : 1

m94*m96*0.1

nodelay

--

true

0

false

PMID: 17576036, 15032587 These proteins contain SH2 domains which physically interact with JAKs competitively blocking their interaction with STATs as well as serve as adapters for E3 ubiquitin ligases which target JAKs for degradation.

Go back
685.0, 327.0
27.0, 27.0

p66

p66

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e89

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c187 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 17576036, 16415872 Recently, SOCS1 was reported to also directly interfere with TLR 2 and 4 signaling by inducing rapid degradation of their TIR domain-containing adaptor TIRAP through ubiquitin-mediated proteolysis.

Go back
617.0, 279.0
27.0, 27.0

p67

p67

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000022528 MO000017004

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m6810*m1906*0.1

nodelay

--

true

0

false

PMID: 17576036, 16415872 Recently, SOCS1 was reported to also directly interfere with TLR 2 and 4 signaling by inducing rapid degradation of their TIR domain-containing adaptor TIRAP through ubiquitin-mediated proteolysis.

Go back
1031.0, 915.0
25.0, 25.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c205 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17576036, 11259387, 12054511, 16293608 Interestingly, SOCS1 mRNA is induced by glucocorticoids in several cell lines of hematopoietic origin and in acute lymphoblastic leukemia (ALL) patients.

Go back
846.0, 344.0
25.0, 25.0

p69

p69

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e91 MO000000286

e94 MO000017115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c204 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m95*m227*0.1

nodelay

--

true

0

false

PMID: 17576036, 15032587 These proteins contain SH2 domains which physically interact with JAKs competitively blocking their interaction with STATs as well as serve as adapters for E3 ubiquitin ligases which target JAKs for degradation.

Go back
1103.0, 1219.0
25.0, 25.0

p7

p7

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e15 G010241

MO000066783

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c20 : 1

m93229*0.1

nodelay

--

true

0

false

PMID: 17576036, 8455596, 2884660, 2038339 Depending on promoter organization, simple GREs could confer either activation (sgk1; tyrosine hydroxylase; chromogranin A) or repression of transcription.

Go back
845.0, 451.0
27.0, 27.0

p70

p70

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e94

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m98*0.1

nodelay

--

true

0

false

PMID: 17576036, 15032587 These proteins contain SH2 domains which physically interact with JAKs competitively blocking their interaction with STATs as well as serve as adapters for E3 ubiquitin ligases which target JAKs for degradation.

Go back
906.0, 1226.0
19.0, 19.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48 e5 MO000000058

G010962

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c208 : 1
stoichiometry:c235 : 1
stoichiometry:c207 : 1

m49*m16*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175, 9430225, 17208592 Glucocorticoid-inducible leucine zipper (GILZ) is a small protein with a wide spectrum of anti-inflammatory activities including inhibition of LPS-induced expression of TLR2 in macrophages and of TLR 2- and 3-mediated NFkappaB activation in airway epithelial cells; inhibition of dendritic cells¡Ç maturation, and enhancement of spontaneous thymocyte apoptosis, likely through downregulation of the anti-apoptotic factor Bcl-X. PMID: 17576036, 11028557, 11160251, 11867630 Transcription of the TLR2 gene in response to TLR agonists is activated by NFkappaB and could therefore be expected to be glucocorticoid-sensitive. PMID: 17576036 In HeLa cervical carcinoma cells, the basal TLR2 expression is low but is induced upon exposure to lipoprotein from the Gram-negative bacterium Haemophilus influenzae and further potentiated by glucocorticoids. PMID: 17576036,16765091 in dendritic cells, glucocorticoids augment the expression of both TLR2 and TLR4, but inhibit the production of proinflammatory cytokines TNF-alpha and IL-12 in response to TLR agonists, suggesting that TLR2 signaling is blocked downstream of the receptor and that a mere increase in the amount of TLR2 does not relieve this block.

Go back
557.0, 1315.0
21.0, 21.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G011271

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175, 9430225, 17208592 Glucocorticoid-inducible leucine zipper (GILZ) is a small protein with a wide spectrum of anti-inflammatory activities including inhibition of LPS-induced expression of TLR2 in macrophages and of TLR 2- and 3-mediated NFkappaB activation in airway epithelial cells; inhibition of dendritic cells¡Ç maturation, and enhancement of spontaneous thymocyte apoptosis, likely through downregulation of the anti-apoptotic factor Bcl-X.

Go back
622.0, 1480.0
25.0, 25.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e101 e78

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c213 : 1
stoichiometry:c212 : 1

m107*m81*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175, 11397794 GILZ was reported to physically interact with several effectors of TLR signaling, most notably Fos, Jun and p65/RelA. PMID: 17576036, 17169985, 11397794, 12391160 Interestingly, GILZ homodimerization through the leucine zipper domain is required for its interaction with NFkappaB, but not AP1 or Raf-1, suggesting that GILZ interaction surfaces are partner-specific.

Go back
402.0, 1444.0
25.0, 25.0

p74

p74

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000015

MO000038411

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1

m101*0.1

nodelay

--

true

0

false

PMID: 17576036, 12391160 In addition, GILZ binds to the protein kinase Raf-1 blocking its phosphorylation and, consequently, activation of downstream MAPKs, Erk 1 and 2.

Go back
464.0, 1446.0
21.0, 21.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000000015

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m5*m101*0.1

nodelay

--

true

0

false

PMID: 17576036, 12391160 In addition, GILZ binds to the protein kinase Raf-1 blocking its phosphorylation and, consequently, activation of downstream MAPKs, Erk 1 and 2.

Go back
401.0, 1399.0
27.0, 27.0

p76

p76

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000038411 MO000004670 e96

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c222 : 1
stoichiometry:c283 : 1
stoichiometry:c223 : 1

m16621*m549*0.1

nodelay

--

true

0

false

PMID: 17576036, 12391160 In addition, GILZ binds to the protein kinase Raf-1 blocking its phosphorylation and, consequently, activation of downstream MAPKs, Erk 1 and 2.

Go back
305.0, 1399.0
27.0, 27.0

p77

p77

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000004676 e98 e96

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c224 : 1
stoichiometry:c316 : 1
stoichiometry:c221 : 1

m554*m103*0.1

nodelay

--

true

0

false

PMID: 17576036, 12391160 In addition, GILZ binds to the protein kinase Raf-1 blocking its phosphorylation and, consequently, activation of downstream MAPKs, Erk 1 and 2.

Go back
548.0, 1458.0
21.0, 21.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000000279

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c229 : 1
stoichiometry:c227 : 1

m5*m221*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175, 11397794 GILZ was reported to physically interact with several effectors of TLR signaling, most notably Fos, Jun and p65/RelA.

Go back
509.0, 1459.0
19.0, 19.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000000049

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c230 : 1
stoichiometry:c228 : 1

m5*m106*0.1

nodelay

--

true

0

false

PMID: 17576036, 11468175, 11397794 GILZ was reported to physically interact with several effectors of TLR signaling, most notably Fos, Jun and p65/RelA.

Go back
1126.0, 1058.0
27.0, 27.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e15 G010266

MO000062960

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m93252*0.1

nodelay

--

true

0

false

PMID: 17576036, 8455596, 2884660, 2038339 Depending on promoter organization, simple GREs could confer either activation (sgk1; tyrosine hydroxylase; chromogranin A) or repression of transcription.

Go back
574.0, 1432.0
26.0, 26.0

p80

p80

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e5

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 17576036, 17169985, 11397794, 12391160 Interestingly, GILZ homodimerization through the leucine zipper domain is required for its interaction with NFkappaB, but not AP1 or Raf-1, suggesting that GILZ interaction surfaces are partner-specific.

Go back
863.0, 1047.0
25.0, 25.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17576036, 11259387, 9430225, 12393603 GILZ is dramatically induced by glucocorticoids in a wide range of cell types, and this induction requires the GR dimer interface and DNA binding, suggesting that GILZ is a direct transcriptional target for the receptor.

Go back
968.0, 1674.0
30.0, 30.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c237 : 1
stoichiometry:c238 : 1

m3964*m109*0.1

nodelay

--

true

0

false

PMID: 17576036, 12356755 ectopic overexpression of TLR2 in HeLa cells indeed results in elevated transcription of TNF-alpha, IL-8 and IL-1¦Â in response to TLR2 agonists.

Go back
952.0, 1434.0
30.0, 30.0

p83

p83

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010962

MO000019397

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c240 : 1

m93848*0.1

nodelay

--

true

0

false

PMID: 17576036, 12356755 ectopic overexpression of TLR2 in HeLa cells indeed results in elevated transcription of TNF-alpha, IL-8 and IL-1¦Â in response to TLR2 agonists.

Go back
893.0, 1327.0
21.0, 21.0

p84

p84

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104 e13

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c255 : 1
stoichiometry:c244 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 17576036, 12356755 ectopic overexpression of TLR2 in HeLa cells indeed results in elevated transcription of TNF-alpha, IL-8 and IL-1beta in response to TLR2 agonists. PMID: 17576036,16765091 in dendritic cells, glucocorticoids augment the expression of both TLR2 and TLR4, but inhibit the production of proinflammatory cytokines TNF-alpha and IL-12 in response to TLR agonists, suggesting that TLR2 signaling is blocked downstream of the receptor and that a mere increase in the amount of TLR2 does not relieve this block.

Go back
860.0, 1342.0
23.0, 23.0

p85

p85

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

G010909

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c245 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 17576036, 12356755 ectopic overexpression of TLR2 in HeLa cells indeed results in elevated transcription of TNF-alpha, IL-8 and IL-1¦Â in response to TLR2 agonists.

Go back
829.0, 1351.0
21.0, 21.0

p86

p86

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c246 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 17576036, 12356755 ectopic overexpression of TLR2 in HeLa cells indeed results in elevated transcription of TNF-alpha, IL-8 and IL-1¦Â in response to TLR2 agonists.

Go back
738.0, 1364.0
19.0, 19.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c248 : 1

m110*0.1

nodelay

--

true

0

false

Go back
674.0, 1364.0
20.0, 20.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
772.0, 1100.0
24.0, 24.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c251 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17576036,16765091 in dendritic cells, glucocorticoids augment the expression of both TLR2 and TLR4, but inhibit the production of proinflammatory cytokines TNF-alpha and IL-12 in response to TLR agonists, suggesting that TLR2 signaling is blocked downstream of the receptor and that a mere increase in the amount of TLR2 does not relieve this block.

Go back
972.0, 880.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e13 MO000000058

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m13*m16*0.1

nodelay

--

true

0

false

PMID: 17576036, 2169352, 10995388, 9388192 Tethering GREs do not contain bona fide DNA recognition sequence for GR, but rather a binding site for another transcription factor which recruits GR through protein:protein interactions. Binding to tethering GREs often requires neither GR DNA binding activity nor its dimerization. Several transcription factors, including AP1, NFkappaB, Stat3 and Stat5 can provide a ¡Ètether¡É for GR.

Go back
872.0, 1000.0
23.0, 23.0

p90

p90

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c254 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17576036,16765091 in dendritic cells, glucocorticoids augment the expression of both TLR2 and TLR4, but inhibit the production of proinflammatory cytokines TNF-alpha and IL-12 in response to TLR agonists, suggesting that TLR2 signaling is blocked downstream of the receptor and that a mere increase in the amount of TLR2 does not relieve this block.

Go back
613.0, 1351.0
21.0, 21.0

p91

p91

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104 e107

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c263 : 1
stoichiometry:c265 : 1

m110*m113*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
706.5, 1368.5
19.0, 19.0

p92

p92

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104 e107

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c264 : 1
stoichiometry:c266 : 1

m110*m113*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
766.5, 1364.5
19.0, 19.0

p93

p93

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104 e109

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c274 : 1
stoichiometry:c267 : 1

m110*m115*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
687.5, 1685.5
23.0, 23.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e106 MO000000289

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c262 : 1

m112*m230*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
642.5, 1356.5
19.0, 19.0

p95

p95

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e109 e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c273 : 1
stoichiometry:c268 : 1

m115*m110*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
780.5, 1686.5
21.0, 21.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e108 MO000016665

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c271 : 1

m114*m1639*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
798.5, 1360.5
19.0, 19.0

p97

p97

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104 e13

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c280 : 1
stoichiometry:c275 : 1

m110*m13*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
577.5, 1339.5
21.0, 21.0

p98

p98

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104 e13

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c276 : 1

m110*m13*0.1

nodelay

--

true

0

false

PMID: 17576036, 15242847 Similarly, in the A549 lung epithelial cell line, the induction of IL-6 and IL-8 by TLR2 agonist peptidoglycan is enhanced by co-treatment with TNF-alpha, IFNgamma and glucocorticoid.

Go back
861.0, 681.0
25.0, 25.0

p99

p99

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e116

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c282 : 1

m122*0.1

nodelay

--

true

0

false

PMID: 17576036 Several IRFs, including IRF1, 2, 3, 5 and 7 interact with CBP/p300 coactivators through the C-terminal IAD domain.

Go back
1080.0, 757.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1023.991972499923, 1114.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
290.0, 321.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.0856580228888, 275.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.83231466980436, 187.7873373466686

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.0, 186.6856438376102

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.91152490811936, 148.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.65685424949237, 150.65685424949237

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.7431017633523, 151.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.9975603804354, 144.24695047554425

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
225.24695047554425, 330.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 142.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.3292929262616, 1123.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.0, 145.71337725959555

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 197.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.0, 238.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.44326714253674, 260.9321961470599

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.0, 265.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.0, 325.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.0, 325.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 340.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
591.0, 381.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 381.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.6568542494924, 1128.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.0, 381.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
457.0, 394.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 438.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.5894663844041, 425.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.0, 441.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 447.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.0, 488.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.0, 488.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.0, 560.1701742519247

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.0, 560.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
991.2950039375453, 1156.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.9147390518303, 499.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
554.3855132026658, 571.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
479.0, 608.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 608.4906692092933

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.5074104802507, 618.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.0, 673.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.016770142732, 694.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 604.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 623.9699247055655

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.0, 604.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1031.871832634471, 1169.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.0, 399.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.3065262678806, 446.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 438.40971801578524

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
694.0, 489.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 489.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.0, 501.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.0, 615.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
760.6568542494924, 624.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.0, 676.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
126.0, 478.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.0, 1123.0

c15

c15

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
180.0, 478.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
172.0, 487.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.9963683321428, 261.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 554.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
229.0, 609.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.9975603804354, 570.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.04795543439116, 617.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
299.0, 653.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.0, 658.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.4708276965784, 730.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.0, 1078.2876109329547

c16

c16

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
317.6039472493969, 799.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 786.319744306791

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
306.0, 850.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.0, 915.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 982.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 1222.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.0, 469.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
229.0, 522.8739464471706

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 502.56892908110547

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.4278135270821, 494.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.0, 1238.4522509287156

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.4278135270821, 496.9711254108328

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.5339352927587, 565.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.4782686447068, 568.8417420849886

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.9314397197344, 612.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.72456828074905, 619.333610669816

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 724.1859962219901

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.3510251680131, 684.8646150223079

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.4168805256332, 610.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
635.0, 652.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.3806483740045, 537.2506011179308

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
999.0, 1091.688577200316

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.7133772595955, 603.464060241731

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.7716860229682, 663.2596089499316

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.864482391554, 711.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 671.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
554.9782745568792, 689.416331058278

c184

c184

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
699.7717736075092, 609.3318122441609

c185

c185

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
631.0, 257.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.0, 341.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.6568542494924, 239.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
644.0, 293.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.5909734841225, 1085.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.6480838483988, 947.828398279894

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
699.0, 304.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.0, 223.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.9750571488127, 239.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.0, 285.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.0, 233.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.3692975529848, 234.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.0, 272.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.0, 267.44397641023085

c198

c198

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
859.0, 305.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.972366065959, 821.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 1244.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 369.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.6233193339639, 230.5576580811817

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 417.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.0, 478.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.9844206278631, 354.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1025.7455923043988, 902.4404466988269

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.0, 16.525118736166633

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 1245.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 1241.5792727023706

c208

c208

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
530.0, 1339.4729725684979

c209

c209

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1005.6564023547028, 963.4376015698018

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.7873373466687, 1321.8323146698044

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 1457.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
635.0, 1505.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.9999235368384, 544.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.4436087949382, 1418.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 1475.1256389183168

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.0, 1426.2394443073426

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 1466.5777087639997

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.33701495857673, 1467.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
435.9810426273839, 1410.0

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
999.6568542494924, 939.6568542494924

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 1433.9818007862912

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.0, 1426.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 1373.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
391.0, 1413.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 1413.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.0, 1418.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.3897804297072, 1418.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.7431017633522, 1479.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.74351979122076, 1478.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.2738595105969, 1486.897928965701

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.5582369741647, 909.5743802511992

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 1483.9278956114879

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 1413.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.0, 1445.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.6039626014052, 1005.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.6286613210731, 1065.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 764.5838809810493

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
983.0, 1611.0

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.0, 1689.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.2519285685115, 1629.7765111560652

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 1301.0

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
903.0, 818.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0, 1464.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.9750571488127, 1389.2648867799865

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.7898696961713, 1379.4977748084605

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
876.824491210522, 1372.7891740141513

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.9402850002907, 1310.7611400011626

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.1966833641114, 1310.3335677176674

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.2394443073428, 1342.0455126623185

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.7993272384815, 1355.9599670832122

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
751.0, 1351.7611400011626

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.8371138487884, 1388.4706582708375

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
969.5777087639997, 863.1554175279994

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.0, 1334.8605619655766

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.0097272694131, 1118.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
799.7097658881296, 1007.0

c252

c252

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
902.9820434321972, 1001.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
869.1554175279994, 1020.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
917.776552737802, 1023.0

c255

c255

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
496.0, 1371.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.4752217960356, 1390.6311680627389

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.5115043525943, 1393.7985618709586

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.2728160290454, 1374.9650557968416

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
956.0, 893.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.0, 1657.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 1697.0

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0, 1661.8208100192876

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0398199919103, 1379.399965838893

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
717.602726517763, 1395.977262735098

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
634.0, 1327.37431120751

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.0, 1350.005708135382

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.5298221281347, 1351.5894663844042

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.0, 1333.145770236779

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.0, 1641.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.6568542494924, 880.6568542494924

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0, 1697.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.0, 1647.000272339342

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.7259108037559, 1382.4549025612275

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0690099645639, 1379.212208557802

c273

c273

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.8965054893599, 1391.7719538681613

c274

c274

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
780.1256389183169, 1346.1455366913863

c275

c275

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 1320.5298221281348

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.7005280535601, 1387.0926787693236

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.4241604923027, 1362.767615962841

c278

c278

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.4258985639995, 1012.0

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
961.0, 930.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.5139680592564, 1023.0

c280

c280

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
887.6039472493969, 546.0

c281

c281

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.3134845335628, 706.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.91917073502384, 1429.8929584071598

c283

c283

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
452.0, 1234.0

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.907210949452, 1168.0

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.0, 1270.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.5116281122666, 1150.0

c287

c287

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 1203.550416732923

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 1214.0

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.2725185831542, 928.3332376839458

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.0, 1097.8627072740333

c290

c290

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
751.0660819247206, 1161.0

c291

c291

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
587.0, 1227.5150582239837

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.0, 1246.8161052203986

c293

c293

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 1265.5689290811056

c294

c294

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 1281.0

c295

c295

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
590.6133398061052, 1008.0

c296

c296

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
597.5032187092917, 1009.0

c297

c297

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
601.3534308532782, 1010.0

c298

c298

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
594.0, 1262.0

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1086.0, 837.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.72987951681, 985.0613012044827

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.0, 1303.758472741024

c300

c300

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.5809334652373, 1161.0

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 1164.0

c302

c302

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0309682041927, 1222.0

c303

c303

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.1049848795938, 668.0

c304

c304

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.0, 785.0

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 426.0

c306

c306

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 472.0

c307

c307

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
988.0, 485.0

c308

c308

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
48.19208584309766, 368.3293928580972

c309

c309

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
953.0, 963.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0976456401591, 756.0064734464356

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.3311913329078, 763.2021295477068

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.6499055497528, 766.0

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.0, 628.0

c313

c313

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.7294278030124, 637.0

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.0482952129478, 4.199190398919143

c315

c315

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.0755370811424, 1426.557551888529

c316

c316

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
862.4486438735934, 673.0

c317

c317

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.6908218931359, 752.0

c318

c318

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.0, 1059.1079380697522

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.9615792869974, 973.7831061593768

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
666.0, 1089.3907269122121

c320

c320

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 1079.7546727037216

c321

c321

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 1078.1103534591628

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.6324329047264, 953.0

c323

c323

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.145770236779, 1023.0

c324

c324

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.6209593782961, 886.0

c325

c325

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.4090509434968, 1035.0

c326

c326

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 941.4125928343757

c327

c327

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.0, 997.3666295529669

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 902.0297874935383

c329

c329

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.8954630462055, 1002.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 949.9294846883888

c330

c330

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.0, 556.0

c331

c331

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 712.0

c332

c332

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.9989221101947, 1023.0

c333

c333

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.7705935588815, 1217.0

c334

c334

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 1214.707608169512

c335

c335

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
505.20223925851155, 1089.0

c336

c336

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.9313321380904, 924.4436074517803

c337

c337

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.0, 1003.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.6857134627292, 1016.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.6969247617094, 1011.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 1101.878837950726

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.1427308552417, 1090.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
963.7230094336443, 1016.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.6208448322877, 915.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.0, 1127.0588235294117

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.4190429152095, 1120.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.98677551382514, 817.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.0, 884.253768895108

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.738977787042, 840.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.0, 878.0829894255471

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.9382230137094, 861.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 883.5280520215392

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.9936076697743, 888.319744306791

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 895.3882352941176

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.3730830011045, 992.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.0, 809.8608380291771

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 812.1966833641114

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 826.6655272802915

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.0, 863.3966562177775

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.0, 911.8371905383993

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
162.70814327703954, 528.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.0, 908.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.0, 929.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.0, 950.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 973.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.4795369723442, 1061.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.0, 994.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 1016.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 1036.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
487.0, 1048.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.55041673292305, 1025.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.0, 928.4204706649821

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 936.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 939.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 942.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 947.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.9829401484266, 1023.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.0, 948.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 948.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.099660075834, 948.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.9867195334049, 925.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.8010628463317, 951.7729688287118

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.35887734267106, 763.9598003413366

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.5894663844041, 973.5298221281347

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.7839864320407, 997.2399915200255

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.8874480940947, 1020.416452246567

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.367306591753, 1041.9322862329902

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 1092.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.0, 948.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 1048.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.09187087814144, 1054.8743430752777

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.5664562694431, 1055.5771566050225

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.3114520150781, 948.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.25264843470626, 1047.9013208958395

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.26875577718766, 1040.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.43018827706084, 948.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.1313708498985, 1032.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.42047066498213, 1039.9889426346601

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.738977787042, 1104.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.996329433163, 80.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 101.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.5136810560396, 93.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.0, 168.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.8255999415425, 161.48291759203994

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 216.99408939705052

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.7381712052921, 209.31242957138693

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0, 160.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.2332154634527, 156.05090537961715

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.0027563130251, 56.63013636419413

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back