1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17621314.csml convertedTime:2009.07.01.11:05

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The negative regulation of Toll-like receptor and associated pathways.
Authors Lang T, Mansell A.
Affiliation Centre for Functional Genomics and Human Disease, Monash Institute of MedicalResearch, Monash University, Victoria, Australia.
Abstract Toll-like receptors (TLRs) are essential mediators of both innate and adaptiveimmunity by recognizing and eliciting responses upon invasion of pathogens. Theresponse of TLRs must be stringently regulated as exaggerated expression ofsignalling components as well as pro-inflammatory cytokines can have devastatingeffects on the host, resulting in chronic inflammatory diseases, autoimmunedisorders and aid in the pathogenesis of TLR-associated human diseases.Therefore, it is essential that negative regulators act at multiple levelswithin TLR signalling cascades, as well as through eliciting negative-feedbackmechanisms in order to synchronize the positive activation and negativeregulation of signal transduction to avert potentially harmful immunologicalconsequences. This review explores the various mechanisms employed by negativeregulators to ensure the appropriate modulation of both immune and inflammatoryresponses.
PMID 17621314
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010389:IL-1beta G010657:IL-12 p40 G010693:Tlr4 G010961:TLR1 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK-1 MO000000254:p50:RelA-p65:IkappaB-alpha{p} MO000000289:TNF-alpha MO000000314:GPCR MO000004670:ERK1 MO000004676:ERK2 MO000007384:IL-6 MO000007694:IRF-3 MO000016569:IRAK-M MO000016573:MyD88 MO000016591:A20 MO000016597:IL-1beta MO000016653:RP105 MO000016660:IFNbeta MO000016661:IKK-alpha:IKK-beta:IKK-gamma MO000016882:LPS MO000016886:SHP-2 MO000016964:TRAF4 MO000017004:SOCS-1 MO000017072:beta-arrestin MO000017073:beta-arrestin1 MO000017074:beta-arrestin2 MO000017247:IL-10 MO000017264:IL-8 MO000017265:IL-12 MO000017443:TGFbeta1 MO000018132:CD14 MO000018424:sst2 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000019406:Tollip MO000022200:MD-1 MO000036861:ATF-3 MO000038724:p50:RelA-p65:IkappaB-alpha MO000039077:IRAK-4 MO000039097:Tollip:IRAK MO000041125:TRIF MO000041132:TRAM MO000041169:CYLD MO000041456:IRF-3{p} MO000042012:TLR9 MO000042032:PGN MO000043372:DcTRAIL-R1 MO000044786:ST2 MO000044794:ST2L MO000061958:TRIAD3 MO000064816:TRAF7 MO000066718:SIGIRR MO000068831:MAL e1: e10: e100:BTK e101:GPCR ligand: GPCR e102:GPCR ligand e103:GPCR ligand: GPCR: beta-arrestin e104:GPCR ligand: GPCR: beta-arrestin: ERK1 e105:GPCR ligand: GPCR: beta-arrestin: ERK2 e106:GPCR ligand: GPCR: beta-arrestin: JNK e107:GPCR ligand: GPCR: beta-arrestin: p38 e108:GPCR ligand: GPCR: beta-arrestin: ERK1{p} e109:GPCR ligand: GPCR: beta-arrestin: ERK2{p} e11:ligand: TLR: MyD88 e110:GPCR ligand: GPCR: beta-arrestin: JNK{p} e111:GPCR ligand: GPCR: beta-arrestin: p38{p} e112:GPCR ligand: GPCR: beta-arrestin: ERK1{p}{ub} e113:GPCR ligand: GPCR: beta-arrestin: ERK2{p}{ub} e114:GPCR ligand: GPCR: beta-arrestin: JNK{p}{ub} e115:GPCR ligand: GPCR: beta-arrestin: p38{p}{ub} e116:p50:RelA-p65:IkappaB-alpha: beta-arrestin-1 e117:p50:RelA-p65:IkappaB-alpha: beta-arrestin-2 e118:TRAF6: beta-arrestin-1 e119:TRAF6: beta-arrestin2 e12:TLR4: MD-2 e120:AP-1{activated} e121:AP-1 e122:IL-8 e123:PI3K class I e124:PI3K class III e125:TGFbeta1: MyD88 e126:cytokine e127:cytokine e128:p53 e129:LIND e13:LPS: CD14 e130:LIND: A20 e131:LIND e132:ABIN-3 e133:Fliih e134:Fliih: MyD88 e135:lipid A e136:LPS: CD14: TLR4: MD-2: MAL: MyD88 e137:FLN29 e138:FLN29: TRAF6 e139:nitric oxide e14:LPS: CD14: TLR4: MD-2 e140:MALP-2 e141:MALP-2: TLR2 e142:Pam3CSK-4 e143:Pam3CSK-4: TLR2 e144:CYLD e145:CYLD: TRAF6 e146:TRAF6: CYLD e147:DUSP e148:DUSP: MAPKs e149:DUSP-1 e15:LPS: CD14: TLR4: MD-2: MAL e150:DUSP-2 e151:p38 e152:DUSP-2: P38 e153:DUSP-2: ERK e154:DUSP-2: JNK e155:JNK e156:p38{p} e157:ERK{activated} e158:DUSP-2: PAC-1 e159:TAK1 e16: e160:IRAK-1{p}: IRAK-4: TRAF6{ub}: TAK1 e161:SHP-2: TAK1 e162:PIN-1 e163:PIN-1: IRF-3{p} e164:PIN-1: IRF-3{p}{ub} e165:p65 e166:PIN-1: p65 e167:PIN-1: p65{p} e168:p65{p} e169:SOCS-1: p65 e17: e170:p65{ub} e171:Ubc13 e172:JNK{p} e173:TRAF2 e174:TRAF2{ub} e175:IKK-alpha:IKK-beta:IKK-gamma{ub} e176:IKK-alpha:IKK-beta:IKK-gamma{p} e177:DC-SIGN e178:ManLAM e179:ManLAM: DC-SIGN e18: e180:IL-10 e181:Raf1 e182:Raf1{activated} e183:p50: RelA-p65{p} e184:p50: RelA-p65{Ac} e185:p47phox e186:p47phox: TRAF4 e187:p47phox: TRIF: TRAF4: TRAF6: IRAK1: e19:poly I: C e2: e20:poly I: C: TLR3 e21:polyI: C: TLR3: TRIF e22:LPS: CD14: TLR4: MD-2: TRAM e23:LPS: CD14: TLR4: MD-2: TRAM: TRIF e24:PGN: TLR2 e25:PGN: TLR2: MAL e26:sTLR e27:ligand: sTLR e28:SARM e29:sTLR2 e3: e30:sCD14 e31:Lipoprotein e32:Lipoprotein: sCD14 e33:Lipoprotein: sCD14: sTLR2 e34:ligand: TLR: MyD88: MyD88 e35:ligand: TLR: MyD88: MyD88: IRAK-1: IRAK-4 e36:MyD88s e37:ligand: TLR: MyD88: MyD88s e38:ligand: TLR: MyD88: MyD88: IRAK-1{p}: IRAK-4 e39:ligand: TLR: MyD88: MyD88: IRAK-1: Tollip-1: IRAK-4 e4: e40:IRAK-1{p}: IRAK-4 e41:IRAK-1{p}: IRAK-4: TRAF6 e42:ST2L: MAL e43:MyD88: ST2L e44:ssT2: ST2 e45:SIGIRR e46:IL-1 e47:IL-1RI: IL-1RII e48:IL-1: IL-1RI: IL-1RII e49:IL-1: IL-1RI: IL-1RII: MyD88 e5:ligand e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:ligand: TLR e60: e61: e62: e63:IL-1: IL-1RI: IL-1RII: MyD88: IRAK-1: Tollip: IRAK-4 e64:IL-1: IL-1RI: IL-1RII: MyD88: IRAK-1: IRAK-4: TRAF6 e65:IL-1: IL-1RI: IL-1RII: MyD88: IRAK-1: IRAK-4: TRAF6: SIGIRR e66:p50:RelA-p65 e67:protein remnants e68:p50:RelA-p65{nucleus} e69:RP105: MD-1 e7: e70:RP105: MD-1: TLR4: MD-2 e71:TRAIL e72:TRAIL: DcTRAIL-R1 e73:IL-6 e74:IL-6: p50: RelA-p65 e75:SARM e76:iL-33 e77:IL-23: ST2 e78:MAPKs{activated} e79:TLR4 e8: e80:LPS: sTLR4 e81:SARM: TRIF e82:IRAK-2a e83:IRAK-2b e84:IRAK-2c e85:IRAK-2d e86:IL-1RAcP e87:IL-1: IL-1RI: IL-1RII: IL-1RAcP e88:Tollip-1 e89:TLR4 e9: e90:Tollip-1: TLR4 e91:Tollip-1: TLR2 e92:ligand: TLR: MyD88: MyD88: IRAK-1: Tollip-1{p}: IRAK-4 e93:A20 e94:TNF-alpha{extracellular} e95:IRAK-1{p}: IRAK-4: TRAF6{ub} e96:RIP-1 e97:SOCS-1 e98:MAL{ub}: SOCS-1 e99:MAL: SOCS-1

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p130 p131 p132 p133 p134 p135 p136 p137 p138 p139 p14 p140 p141 p142 p143 p144 p145 p146 p147 p148 p149 p15 p150 p151 p152 p153 p154 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
719.0, 1471.0
26.0, 26.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p154

p129

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
858.0, 1515.0
24.5, 24.5

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35 p118

p43

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
877.0, 1554.0
26.0, 26.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p36 p117

p44

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
899.0, 1595.0
25.0, 25.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p37

p45

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
685.0, 1651.0
27.0, 27.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p93

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
982.0, 1732.0
26.0, 26.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p25

--

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
934.0, 1732.0
26.0, 26.0

TLR1

--

G010961

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24

--

true true true true

csml-variable:Double

m93847

10

false

infinite

0

unit false false false
TRANSFACG010961

--

Go back
777.0, 973.0
29.5, 29.5

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p120 p123

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
384.0, 1008.0
22.0, 22.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
382.0, 938.0
26.0, 26.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1207.0, 1471.0
33.0, 33.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p115 p48 p112 p116

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1184.5, 825.0
27.0, 27.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p30 p89 p90 p104 p113 p153

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1165.0, 577.0
19.0, 19.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p153

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1072.0, 1308.0
38.5, 38.5

p50:RelA-p65:IkappaB-alpha{p}

--

MO000000254

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p47 p52 p53 p58 p49 p108

p33

true true true true

csml-variable:Double

m208

10

false

infinite

0

unit false false false
TRANSPATHMO000000254

--

Go back
534.0, 1559.0
24.0, 24.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

p99

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
225.0, 821.0
28.0, 28.0

GPCR

--

MO000000314

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m249

10

false

infinite

0

unit false false false
TRANSPATHMO000000314

--

Go back
381.0, 789.0
28.5, 28.5

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
380.0, 860.0
29.5, 29.5

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
533.0, 1515.0
27.0, 27.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
669.0, 625.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p127 p128

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1174.0, 706.0
23.5, 23.5

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
1107.0, 484.0
34.0, 34.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p22 p28 p94 p102 p103

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1080.0, 884.0
23.0, 23.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63 p100

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
519.0, 1595.0
33.0, 33.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
757.0, 298.0
25.0, 25.0

RP105

--

MO000016653

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m1632

10

false

infinite

0

unit false false false
InterProIPR000483
TRANSPATHMO000016653

--

Go back
538.0, 1362.0
27.0, 27.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p129

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
803.0, 1055.0
33.0, 33.0

IKK-alpha:IKK-beta:IKK-gamma

--

MO000016661

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p142 p143 p144

true true true true

csml-variable:Double

m1637

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
960.0, 174.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p24 p25 p26 p40 p38 p50 p51 p52 p53 p61 p69 p92 p101 p105 p146

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
789.0, 625.0
30.0, 30.0

SHP-2

--

MO000016886

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p126 p127 p128

true true true true

csml-variable:Double

m1807

10

false

infinite

0

unit false false false
InterProIPR000242
TRANSPATHMO000016886

--

Go back
265.0, 1481.0
22.0, 22.0

TRAF4

--

MO000016964

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p152 p153

true true true true

csml-variable:Double

m1873

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016964

--

Go back
827.0, 591.0
25.0, 25.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

p71 p138

p58 p72 p137

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
289.0, 809.0
27.0, 27.0

beta-arrestin

--

MO000017072

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74

true true true true

csml-variable:Double

m1964

10

false

infinite

0

unit false false false
TRANSPATHMO000017072

--

Go back
1220.0, 1108.0
22.0, 22.0

beta-arrestin1

--

MO000017073

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87 p89 p92

true true true true

csml-variable:Double

m1965

10

false

infinite

0

unit false false false
InterProIPR000698
TRANSPATHMO000017073

--

Go back
911.0, 1271.0
23.0, 23.0

beta-arrestin2

--

MO000017074

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88 p90 p92

true true true true

csml-variable:Double

m1966

10

false

infinite

0

unit false false false
InterProIPR000698
TRANSPATHMO000017074

--

Go back
590.0, 1874.0
27.0, 27.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p147

p96 p97

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1238.0, 1596.0
25.0, 25.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p92

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
523.0, 1655.0
25.0, 25.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1061.0, 487.0
27.0, 27.0

TGFbeta1

--

MO000017443

cso30:c:Protein

cso30:i:CC_CellComponent

--

p95

p25 p94

true true true true

csml-variable:Double

m2269

10

false

infinite

0

unit false false false
InterProIPR002400
TRANSPATHMO000017443

--

Go back
937.0, 217.0
30.0, 30.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
701.0, 2057.0
30.0, 30.0

sst2

--

MO000018424

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m3062

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000018424

--

Go back
1327.0, 398.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
630.0, 299.0
26.0, 26.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p55 p106 p107

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
319.0, 447.0
23.0, 23.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1169.0, 649.0
29.0, 29.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

p57

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
754.0, 347.0
24.0, 24.0

MD-1

--

MO000022200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m6500

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022200

--

Go back
886.0, 1796.0
25.0, 25.0

ATF-3

--

MO000036861

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p98 p99

true true true true

csml-variable:Double

m15174

10

false

infinite

0

unit false false false
InterProIPR000837
TRANSPATHMO000036861

--

Go back
1024.0, 1208.0
30.0, 30.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p47 p52 p53 p58 p87 p88 p49 p108

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
1166.0, 606.0
25.5, 25.5

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p29

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1142.0, 1010.0
25.5, 25.5

Tollip:IRAK

--

MO000039097

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m17273

10

false

infinite

0

unit false false false
TRANSPATHMO000039097

--

Go back
612.0, 412.0
29.0, 29.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p9 p51 p68 p153

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
933.0, 415.0
27.5, 27.5

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
686.0, 1210.0
28.0, 28.0

CYLD

--

MO000041169

cso30:c:Protein

cso30:i:CC_CellComponent

--

p111

p108 p113 p114 p112 p124

true true true true

csml-variable:Double

m19042

10

false

infinite

0

unit false false false
TRANSPATHMO000041169

--

Go back
653.0, 677.0
30.5, 30.5

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p127 p128

p129 p130

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
332.0, 576.0
24.5, 24.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
668.0, 146.0
22.0, 22.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
1348.0, 1364.0
31.5, 31.5

DcTRAIL-R1

--

MO000043372

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m21137

10

false

infinite

0

unit false false false
TRANSPATHMO000043372

--

Go back
872.0, 1996.0
32.0, 32.0

ST2

--

MO000044786

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p46

true true true true

csml-variable:Double

m22456

10

false

infinite

0

unit false false false
TRANSPATHMO000044786

--

Go back
1265.0, 271.0
28.0, 28.0

ST2L

--

MO000044794

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22

true true true true

csml-variable:Double

m22464

10

false

infinite

0

unit false false false
TRANSPATHMO000044794

--

Go back
269.0, 473.0
28.0, 28.0

TRIAD3

--

MO000061958

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64 p65 p66 p67

true true true true

csml-variable:Double

m36851

10

false

infinite

0

unit false false false
TRANSPATHMO000061958

--

Go back
730.0, 1066.0
28.0, 28.0

TRAF7

--

MO000064816

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p114

true true true true

csml-variable:Double

m39686

10

false

infinite

0

unit false false false
TRANSPATHMO000064816

--

Go back
1315.0, 1163.0
25.5, 25.5

SIGIRR

--

MO000066718

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m41575

10

false

infinite

0

unit false false false
TRANSPATHMO000066718

--

Go back
1026.0, 383.0
32.5, 32.5

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p11 p21 p66 p72

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
145.82894206725555, 247.21103918475904
1250.9896660751574, 1800.0654878471412

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
154.32283671317037, 266.59958150330533
1215.379401011698, 1694.2876086170204

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1032.125, 501.5
21.45798953511773, 34.7967397866774

BTK

--

e100

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p72

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
224.625, 864.5
29.409390101649727, 36.01149808365272

GPCR ligand: GPCR

--

e101

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p73

p74

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
66.5, 824.375
32.170474516695954, 20.910808435852374

GPCR ligand

--

e102

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p73

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
224.875, 914.5
28.935630390897412, 40.37529821985685

GPCR ligand: GPCR: beta-arrestin

--

e103

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p74

p75 p76 p77 p78

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
382.625, 827.5
25.22058823529412, 30.882352941176467

GPCR ligand: GPCR: beta-arrestin: ERK1

--

e104

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

p79

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
386.625, 907.5
25.669680053324445, 31.43226128978504

GPCR ligand: GPCR: beta-arrestin: ERK2

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76

p80

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
381.625, 974.5
26.698508581903017, 32.69205132477921

GPCR ligand: GPCR: beta-arrestin: JNK

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

p81

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
380.625, 1053.5
28.07027995334111, 34.37177137143809

GPCR ligand: GPCR: beta-arrestin: p38

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

p82

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
513.875, 817.5
25.684391631492016, 35.83868599743072

GPCR ligand: GPCR: beta-arrestin: ERK1{p}

--

e108

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

p83

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
508.875, 899.5
27.578317122407782, 38.48137272894109

GPCR ligand: GPCR: beta-arrestin: ERK2{p}

--

e109

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

p84

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
1327.5, 480.0
29.853000550559738, 41.65534960543219

ligand: TLR: MyD88

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p15 p17

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
504.875, 963.5
27.578317122407782, 38.48137272894109

GPCR ligand: GPCR: beta-arrestin: JNK{p}

--

e110

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

p85

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
505.875, 1043.5
27.238988805285373, 38.00789135621215

GPCR ligand: GPCR: beta-arrestin: p38{p}

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

p82

p86

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
631.875, 805.5
30.829555881813178, 43.017984951367225

GPCR ligand: GPCR: beta-arrestin: ERK1{p}{ub}

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83

--

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
637.875, 887.5
27.238988805285373, 38.00789135621215

GPCR ligand: GPCR: beta-arrestin: ERK2{p}{ub}

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
640.875, 951.5
27.846623233620846, 38.8557533492384

GPCR ligand: GPCR: beta-arrestin: JNK{p}{ub}

--

e114

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
640.875, 1031.5
27.507294916498438, 38.38227197650945

GPCR ligand: GPCR: beta-arrestin: p38{p}{ub}

--

e115

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
1188.875, 1119.5
27.578317122407782, 38.48137272894109

p50:RelA-p65:IkappaB-alpha: beta-arrestin-1

--

e116

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

p32 p47 p52 p58 p49

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
1025.875, 1257.5
25.48710772618829, 35.56340612956506

p50:RelA-p65:IkappaB-alpha: beta-arrestin-2

--

e117

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

p32 p47 p52 p53 p58 p49

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
1022.625, 1003.5
26.86998000333278, 32.90201633061156

TRAF6: beta-arrestin-1

--

e118

cso30:c:Complex

cso30:i:CC_Cytosol

--

p89

p63

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
1003.625, 1036.5
25.490043326112318, 31.21229795034161

TRAF6: beta-arrestin2

--

e119

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

p63

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
1018.0, 306.5
39.834976856510366, 24.564902394848065

TLR4: MD-2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p4 p40

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
885.25, 1376.5
13.285781103835362, 30.659494855004677

AP-1{activated}

--

e120

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p91

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
853.25, 1404.5
13.285781103835362, 30.659494855004677

AP-1

--

e121

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p91

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
1060.5, 1567.0
37.110726643598625, 19.792387543252595

IL-8

--

e122

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p109

p92

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
832.0, 1173.5
29.92, 22.44

PI3K class I

--

e123

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p58 p93

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
735.5, 1363.125
28.520000000000003, 21.389999999999997

PI3K class III

--

e124

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p43 p44 p58 p93

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
1200.625, 427.5
28.07027995334111, 34.37177137143809

TGFbeta1: MyD88

--

e125

cso30:c:Complex

cso30:i:CC_Cytosol

--

p94

p95

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
787.5, 1831.0
33.16608996539793, 17.688581314878892

cytokine

--

e126

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p96 p97

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
584.5, 1836.125
39.31273898168646, 24.242855705373316

cytokine

--

e127

cso30:c:Protein

cso30:i:CC_Cytosol

--

p96 p97

--

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
881.5, 1696.0
35.39792387543253, 18.878892733564015

p53

--

e128

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p98

--

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
1033.5, 937.125
28.840000000000003, 21.63

LIND

--

e129

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p58 p100

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
1035.625, 237.5
28.87047992001333, 35.351608065322445

LPS: CD14

--

e13

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1079.625, 920.5
24.959298450258288, 30.562406265622393

LIND: A20

--

e130

cso30:c:Complex

cso30:i:CC_Cytosol

--

p100

--

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
1034.5, 1619.0
35.294117647058826, 18.823529411764707

LIND

--

e131

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p101

--

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
943.5, 1178.125
33.516804185952914, 20.668695914670963

ABIN-3

--

e132

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32 p58

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
852.125, 483.5
21.39097403904206, 34.6880660092574

Fliih

--

e133

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p102

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
896.625, 538.5
29.499208465255787, 36.12147975337444

Fliih: MyD88

--

e134

cso30:c:Complex

cso30:i:CC_Cytosol

--

p102

p58 p103

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
1427.5, 532.25
41.34146341463414, 23.426829268292682

lipid A

--

e135

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p102

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
1128.5, 262.0
31.762708753899794, 44.32005872637181

LPS: CD14: TLR4: MD-2: MAL: MyD88

--

e136

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p103

--

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
1016.0, 746.5
24.479999999999997, 18.359999999999992

FLN29

--

e137

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p104

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
1021.5, 778.0
29.019496750541574, 35.53407765372438

FLN29: TRAF6

--

e138

cso30:c:Complex

cso30:i:CC_Cytosol

--

p104

p20 p30 p44 p105

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
869.0, 785.0
37.54415475189234, 21.275021026072327

nitric oxide

--

e139

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p105

--

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
1072.875, 297.5
27.578317122407782, 38.48137272894109

LPS: CD14: TLR4: MD-2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5 p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
378.0, 146.5
33.18101933216168, 21.567662565905096

MALP-2

--

e140

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p106

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
381.625, 260.5
27.319071821363103, 33.45192467922013

MALP-2: TLR2

--

e141

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p106

--

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
322.5, 162.375
32.170474516695954, 20.910808435852374

Pam3CSK-4

--

e142

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p107

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
324.625, 271.5
29.31957173804366, 35.90151641393101

Pam3CSK-4: TLR2

--

e143

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p107

--

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
742.5, 1691.0
35.24221453287198, 18.795847750865054

CYLD

--

e144

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p110

p111

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false false false

--

Go back
878.625, 943.5
26.6495167472088, 32.632061323112815

CYLD: TRAF6

--

e145

cso30:c:Complex

cso30:i:CC_Cytosol

--

p113

--

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false false false

--

Go back
671.625, 1113.5
23.848816863856023, 29.20263289451758

TRAF6: CYLD

--

e146

cso30:c:Complex

cso30:i:CC_Cytosol

--

p114

--

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false false false

--

Go back
1257.5, 1681.125
36.028375930770785, 22.217498490641983

DUSP

--

e147

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p115

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false false false

--

Go back
1259.625, 1728.5
25.130769871688052, 30.772371271454755

DUSP: MAPKs

--

e148

cso30:c:Complex

cso30:i:CC_Cytosol

--

p115

--

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false false false

--

Go back
1257.5, 1433.125
36.30609780639968, 22.38876031394647

DUSP-1

--

e149

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p116

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false false false

--

Go back
1105.875, 286.5
26.22100385391815, 36.58744723802533

LPS: CD14: TLR4: MD-2: MAL

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p97 p103

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
710.5, 877.125
34.5190179110485, 21.286727711813242

DUSP-2

--

e150

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p119 p120 p121

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false false false

--

Go back
776.5, 832.125
31.720000000000002, 23.789999999999996

p38

--

e151

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p119 p124 p122

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false false false

--

Go back
777.625, 922.5
28.870479920013334, 35.351608065322445

DUSP-2: P38

--

e152

cso30:c:Complex

cso30:i:CC_Cytosol

--

p119

--

true true true true

csml-variable:Double

m159

0

false

infinite

0

unit false false false

--

Go back
715.625, 977.5
24.20809031828028, 29.642559573404426

DUSP-2: ERK

--

e153

cso30:c:Complex

cso30:i:CC_Cytosol

--

p120

--

true true true true

csml-variable:Double

m160

0

false

infinite

0

unit false false false

--

Go back
714.75, 777.5
26.229281767955804, 29.143646408839782

DUSP-2: JNK

--

e154

cso30:c:Complex

cso30:i:CC_Cytosol

--

p121

--

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false false false

--

Go back
773.5, 765.125
29.48, 22.109999999999996

JNK

--

e155

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p121 p140

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false false false

--

Go back
834.5, 870.125
26.76, 20.07

p38{p}

--

e156

cso30:c:Protein

cso30:i:CC_Cytosol

--

p124 p122

p91

true true true true

csml-variable:Double

m163

0

false

infinite

0

unit false false false

--

Go back
713.0, 1017.0
29.5, 29.5

ERK{activated}

--

e157

cso30:c:Protein

cso30:i:CC_CellComponent

--

p123

--

true true true true

csml-variable:Double

m164

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
670.625, 727.5
27.319071821363103, 33.45192467922013

DUSP-2: PAC-1

--

e158

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p123 p122

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false false false

--

Go back
880.5, 692.125
31.560000000000006, 23.669999999999998

TAK1

--

e159

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p125 p126

true true true true

csml-variable:Double

m166

0

false

infinite

0

unit false false false

--

Go back
329.0, 415.0
153.7067870214095, 256.61217833235315

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
938.875, 961.5
26.22100385391815, 36.58744723802533

IRAK-1{p}: IRAK-4: TRAF6{ub}: TAK1

--

e160

cso30:c:Complex

cso30:i:CC_Cytosol

--

p125

p116 p123 p142 p122 p140

true true true true

csml-variable:Double

m167

0

false

infinite

0

unit false false false

--

Go back
846.625, 695.5
26.159598400266628, 32.03216130644893

SHP-2: TAK1

--

e161

cso30:c:Complex

cso30:i:CC_Cytosol

--

p126

p125

true true true true

csml-variable:Double

m168

0

false

infinite

0

unit false false false

--

Go back
509.125, 613.5
22.560022137250954, 36.583819682028576

PIN-1

--

e162

cso30:c:Protein

cso30:i:CC_Cytosol

--

p132 p134

p130 p133

true true true true

csml-variable:Double

m169

0

false

infinite

0

unit false false false

--

Go back
475.625, 676.5
24.51020663222796, 30.01249791701383

PIN-1: IRF-3{p}

--

e163

cso30:c:Complex

cso30:i:CC_Cytosol

--

p130

p129 p131

true true true true

csml-variable:Double

m170

0

false

infinite

0

unit false false false

--

Go back
530.625, 735.5
26.68217797033828, 32.67205465755707

PIN-1: IRF-3{p}{ub}

--

e164

cso30:c:Complex

cso30:i:CC_Cytosol

--

p131

p132

true true true true

csml-variable:Double

m171

0

false

infinite

0

unit false false false

--

Go back
376.5, 1108.125
31.399999999999995, 23.55

p65

--

e165

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p133 p137

true true true true

csml-variable:Double

m172

0

false

infinite

0

unit false false false

--

Go back
377.625, 1170.5
28.960298283619398, 35.46158973504416

PIN-1: p65

--

e166

cso30:c:Complex

cso30:i:CC_Cytosol

--

p133

p135 p138 p139

true true true true

csml-variable:Double

m173

0

false

infinite

0

unit false false false

--

Go back
377.625, 1221.5
29.499208465255787, 36.12147975337444

PIN-1: p65{p}

--

e167

cso30:c:Complex

cso30:i:CC_Cytosol

--

p135

p134

true true true true

csml-variable:Double

m174

0

false

infinite

0

unit false false false

--

Go back
680.5, 1496.125
31.560000000000006, 23.669999999999998

p65{p}

--

e168

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p134

p136

true true true true

csml-variable:Double

m175

0

false

infinite

0

unit false false false

--

Go back
502.625, 1103.5
27.53953507748708, 33.72187968671888

SOCS-1: p65

--

e169

cso30:c:Complex

cso30:i:CC_Cytosol

--

p137

p138

true true true true

csml-variable:Double

m176

0

false

infinite

0

unit false false false

--

Go back
329.0, 415.0
153.7067870214095, 256.61217833235315

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
499.0, 1215.5
33.92000000000001, 25.44

p65{ub}

--

e170

cso30:c:Protein

cso30:i:CC_Cytosol

--

p138

p139

true true true true

csml-variable:Double

m177

0

false

infinite

0

unit false false false

--

Go back
1071.0, 625.5
33.74924532099014, 20.812034614610592

Ubc13

--

e171

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p63 p141 p122 p144

true true true true

csml-variable:Double

m178

0

false

infinite

0

unit false false false

--

Go back
772.5, 728.125
31.080000000000002, 23.31

JNK{p}

--

e172

cso30:c:Protein

cso30:i:CC_Cytosol

--

p140

--

true true true true

csml-variable:Double

m179

0

false

infinite

0

unit false false false

--

Go back
1012.5, 586.125
31.28295431676394, 19.291155162004426

TRAF2

--

e173

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p141 p143

true true true true

csml-variable:Double

m180

0

false

infinite

0

unit false false false

--

Go back
1012.5, 671.75
31.731980405878236, 24.327851644506648

TRAF2{ub}

--

e174

cso30:c:Protein

cso30:i:CC_Cytosol

--

p141

--

true true true true

csml-variable:Double

m181

0

false

infinite

0

unit false false false

--

Go back
809.875, 1104.5
27.515186272710594, 38.39328317122407

IKK-alpha:IKK-beta:IKK-gamma{ub}

--

e175

cso30:c:Complex

cso30:i:CC_Cytosol

--

p142 p143

p58

true true true true

csml-variable:Double

m187

0

false

infinite

0

unit false false false

--

Go back
955.875, 1057.5
27.238988805285373, 38.00789135621215

IKK-alpha:IKK-beta:IKK-gamma{p}

--

e176

cso30:c:Complex

cso30:i:CC_Cytosol

--

p144

--

true true true true

csml-variable:Double

m188

0

false

infinite

0

unit false false false

--

Go back
1201.25, 295.5
14.380261927034612, 33.18521983161834

DC-SIGN

--

e177

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p145

true true true true

csml-variable:Double

m189

0

false

infinite

0

unit false false false

--

Go back
1190.5, 48.375
34.982425307557115, 22.738576449912127

ManLAM

--

e178

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p145

true true true true

csml-variable:Double

m190

0

false

infinite

0

unit false false false

--

Go back
1167.875, 246.5
24.666406680124794, 34.418241879243894

ManLAM: DC-SIGN

--

e179

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p145

p146 p147 p148

true true true true

csml-variable:Double

m191

0

false

infinite

0

unit false false false

--

Go back
329.0, 415.0
153.7067870214095, 256.61217833235315

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false true false

--

Go back
849.5, 1835.625
34.86564299424184, 19.176103646833013

IL-10

--

e180

cso30:c:Rna

cso30:i:CC_Nucleoplasm

--

p151

p147

true true true true

csml-variable:Double

m192

0

false

infinite

0

unit false false false

--

Go back
1270.5, 1875.125
34.28, 25.709999999999997

Raf1

--

e181

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p148

true true true true

csml-variable:Double

m193

0

false

infinite

0

unit false false false

--

Go back
1218.5, 1819.125
34.28, 25.709999999999997

Raf1{activated}

--

e182

cso30:c:Protein

cso30:i:CC_Cytosol

--

p148

p149

true true true true

csml-variable:Double

m194

0

false

infinite

0

unit false false false

--

Go back
1164.5, 1837.125
38.760000000000005, 29.069999999999997

p50: RelA-p65{p}

--

e183

cso30:c:Protein

cso30:i:CC_Cytosol

--

p149

p150

true true true true

csml-variable:Double

m195

0

false

infinite

0

unit false false false

--

Go back
1077.5, 1894.125
36.2, 27.149999999999995

p50: RelA-p65{Ac}

--

e184

cso30:c:Protein

cso30:i:CC_Cytosol

--

p150

p151

true true true true

csml-variable:Double

m196

0

false

infinite

0

unit false false false

--

Go back
264.5, 1424.125
31.400000000000006, 23.549999999999994

p47phox

--

e185

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p152 p153

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
327.625, 1468.5
25.269580069988336, 30.942342942842856

p47phox: TRAF4

--

e186

cso30:c:Complex

cso30:i:CC_Cytosol

--

p152

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
326.875, 1593.5
26.69448522664709, 37.248118920902925

p47phox: TRIF: TRAF4: TRAF6: IRAK1:

--

e187

cso30:c:Complex

cso30:i:CC_Cytosol

--

p153

p58 p154

true true true true

csml-variable:Double

m182

0

false

infinite

0

unit false false false

--

Go back
73.5, 407.25
42.72918418839361, 24.213204373423043

poly I: C

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
145.82894206725555, 247.21103918475904
1250.9896660751574, 1800.0654878471412

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
343.625, 412.5
29.499208465255794, 36.12147975337444

poly I: C: TLR3

--

e20

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p6

p7

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
394.875, 400.5
32.25, 45.0

polyI: C: TLR3: TRIF

--

e21

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p7

p96 p127

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
929.875, 256.5
32.25, 45.0

LPS: CD14: TLR4: MD-2: TRAM

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
881.875, 268.5
32.25, 45.0

LPS: CD14: TLR4: MD-2: TRAM: TRIF

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p128

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
666.625, 291.5
26.600524912514583, 32.57207132144643

PGN: TLR2

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
703.875, 279.5
28.114929344833914, 39.23013396953569

PGN: TLR2: MAL

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p108 p109 p110 p112 p124

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1322.5, 354.125
36.2, 27.15

sTLR

--

e26

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p12

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1323.625, 311.5
27.31907182136311, 33.45192467922013

ligand: sTLR

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p1

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
552.5, 1706.125
29.83397061783056, 18.39761521432884

SARM

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
494.5, 271.125
31.560000000000002, 23.669999999999998

sTLR2

--

e29

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p14

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
170.84873538875866, 272.00532965097324
1200.9500794321502, 1750.4769069147142

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
558.5, 220.125
30.12, 22.59

sCD14

--

e30

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
554.5, 164.375
31.678383128295252, 20.59094903339192

Lipoprotein

--

e31

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
494.625, 216.5
30.02995334110982, 36.77137143809364

Lipoprotein: sCD14

--

e32

cso30:c:Complex

cso30:i:CC_Extracellular

--

p13

p14

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
429.875, 244.5
32.25, 45.0

Lipoprotein: sCD14: sTLR2

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p36 p109

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1322.875, 584.5
32.25, 45.0

ligand: TLR: MyD88: MyD88

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15 p19

p16

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1322.875, 640.5
32.25, 45.0

ligand: TLR: MyD88: MyD88: IRAK-1: IRAK-4

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16 p60

p18 p57

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1133.5, 540.125
31.240000000000002, 23.429999999999996

MyD88s

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1320.875, 529.5
32.25, 45.0

ligand: TLR: MyD88: MyD88s

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p16

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1314.875, 812.5
32.25, 45.0

ligand: TLR: MyD88: MyD88: IRAK-1{p}: IRAK-4

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p19

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1322.875, 692.5
32.25, 45.0

ligand: TLR: MyD88: MyD88: IRAK-1: Tollip-1: IRAK-4

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p18 p58 p59

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
217.13535303353973, 315.3953379668476
1108.3768441425889, 1663.6968902829644

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1220.875, 760.5
21.683474031932462, 30.25601027711507

IRAK-1{p}: IRAK-4

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1065.875, 825.5
25.684391631492016, 35.83868599743072

IRAK-1{p}: IRAK-4: TRAF6

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p63

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1225.5, 277.0
26.267788701883024, 32.16463922679553

ST2L: MAL

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p21

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1308.5, 259.0
29.25629061823029, 35.82402932844527

MyD88: ST2L

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
765.5, 1963.0
28.317280453257784, 34.6742209631728

ssT2: ST2

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p23

p24 p25 p42 p43 p44 p45

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1030.0, 1662.0
36.12456747404845, 19.266435986159177

SIGIRR

--

e45

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1411.0, 869.5
33.70094586435903, 20.78224994968807

IL-1

--

e46

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p27

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1353.5, 875.0
28.390768205299114, 34.76420596567239

IL-1RI: IL-1RII

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p27

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1320.5, 907.0
28.156358964947696, 39.28794274178748

IL-1: IL-1RI: IL-1RII

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p54

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1313.875, 1000.5
32.25, 45.0

IL-1: IL-1RI: IL-1RII: MyD88

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1425.0, 379.5
36.30931458699473, 23.601054481546573

ligand

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1 p12

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
623.8751388951652, 1413.2700198039418
524.8479091092809, 471.6893967871221

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
680.5626225605994, 1424.4483727792735
306.8943081197659, 457.1609759415228

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
630.7167317513382, 1419.5656688370343
511.164723396935, 459.09809872093587

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
631.6941021593628, 1420.534230226741
509.20998258088525, 457.1609759415228

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
623.8751388951652, 1413.2700198039418
524.8479091092809, 471.6893967871221

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
623.8751388951652, 1413.2700198039418
524.8479091092809, 471.6893967871221

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
631.6941021593628, 1420.534230226741
509.20998258088525, 457.1609759415228

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1007.0043388408599, 1606.9822977452648
32.789613582173104, 29.41569483625513

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
920.9957429346836, 1742.5808923041911
92.85018876234949, 83.29627951476901

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
623.8751388951652, 1413.2700198039418
524.8479091092809, 471.6893967871221

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1325.5, 434.0
30.089151808032, 36.84385935677387

ligand: TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
747.5788379563055, 1622.8848901345666
16.621162098496534, 7.930652852541766

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
747.0238103062813, 1599.2338066276122
56.89033412747729, 101.47964900077048

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
770.889999257321, 1665.2368303679511
8.880442400386688, 8.800403165378466

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1315.875, 1047.5
27.578317122407782, 38.48137272894109

IL-1: IL-1RI: IL-1RII: MyD88: IRAK-1: Tollip: IRAK-4

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p30

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1316.875, 1091.5
29.472242613323544, 41.12405946045146

IL-1: IL-1RI: IL-1RII: MyD88: IRAK-1: IRAK-4: TRAF6

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31 p32 p144

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1305.875, 1196.5
39.360111947146265, 54.921086437878515

IL-1: IL-1RI: IL-1RII: MyD88: IRAK-1: IRAK-4: TRAF6: SIGIRR

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p32

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1071.5, 1409.125
40.52, 30.389999999999993

p50:RelA-p65

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34 p149

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
921.5, 1330.25
28.595634692705342, 27.642446869615167

protein remnants

--

e67

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p33 p64 p65 p66 p67 p68 p71 p95 p132 p136 p139

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1011.5, 1449.125
40.52, 30.389999999999993

p50:RelA-p65{nucleus}

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p36 p37 p42

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
800.625, 290.5
26.967963672721208, 33.021996333944344

RP105: MD-1

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p39

p40

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
157.41152567532126, 252.3156116846104
864.5484776948458, 1214.0015766073423

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
840.875, 280.5
27.041704899981646, 37.732611488346485

RP105: MD-1: TLR4: MD-2

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

p32

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1479.5, 1418.125
33.35983095190179, 20.57189575367277

TRAIL

--

e71

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1346.625, 1411.5
27.3190718213631, 33.45192467922013

TRAIL: DcTRAIL-R1

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

p33

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
879.5, 1458.125
45.0, 9.75

IL-6

--

e73

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p42

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
863.5, 1476.625
45.0, 12.75

IL-6: p50: RelA-p65

--

e74

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p42

p35

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
727.5, 1733.0
37.214532871972324, 19.847750865051903

SARM

--

e75

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p50

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1058.5, 2053.125
34.4103441336285, 21.219712215737573

iL-33

--

e76

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p46

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1120.625, 1968.5
31.458881853024494, 38.521079820029996

IL-23: ST2

--

e77

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p46

p47 p48

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1255.0, 1527.0
33.0, 33.0

MAPKs{activated}

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48 p112 p116

p117 p118

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1353.0, 279.0
28.0, 28.0

TLR4

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
160.5002146374721, 273.7415664126527
829.3716564137997, 1193.3937871709059

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1349.625, 229.5
25.93913514414264, 31.762206298950176

LPS: sTLR4

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p38

p4 p58

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
612.625, 501.5
29.188926845525742, 35.74154307615398

SARM: TRIF

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p7 p9

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1253.0, 1257.0
24.0, 24.0

IRAK-2a

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
1264.0, 1304.0
24.0, 24.0

IRAK-2b

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
1255.0, 1331.0
24.0, 24.0

IRAK-2c

--

e84

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p53

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
1253.0, 1369.0
22.0, 22.0

IRAK-2d

--

e85

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p53

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
1256.5, 864.125
31.400000000000002, 23.549999999999997

IL-1RAcP

--

e86

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p54

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1321.875, 956.5
27.578317122407782, 38.48137272894109

IL-1: IL-1RI: IL-1RII: IL-1RAcP

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p28

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
530.5, 375.125
32.84, 24.63

Tollip-1

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p55 p56

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
202.5, 296.125
24.520000000000003, 18.39

TLR4

--

e89

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p56 p64

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
168.73671853654105, 295.16752114069504
825.5851198633923, 1177.742726689585

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
201.625, 241.5
25.93913514414264, 31.762206298950176

Tollip-1: TLR4

--

e90

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p56

p58

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
568.625, 277.5
29.31140643226129, 35.89151808031995

Tollip-1: TLR2

--

e91

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p55

p58

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1318.875, 744.5
32.25, 45.0

ligand: TLR: MyD88: MyD88: IRAK-1: Tollip-1{p}: IRAK-4

--

e92

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p59

p60

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1017.5, 1698.0
37.88927335640138, 20.207612456747405

A20

--

e93

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p61 p62

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1460.0, 1736.0
24.0, 24.0

TNF-alpha{extracellular}

--

e94

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62 p49

true true true true

csml-variable:Double

m101

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
940.875, 827.5
29.472242613323544, 41.12405946045146

IRAK-1{p}: IRAK-4: TRAF6{ub}

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p125

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
285.125, 662.5
21.45798953511773, 34.7967397866774

RIP-1

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p67

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
800.2768166089966, 1766.4809688581315
38.09688581314877, 20.318339100346016

SOCS-1

--

e97

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p69

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
976.0, 523.5
32.0, 24.0

MAL{ub}: SOCS-1

--

e98

cso30:c:Protein

cso30:i:CC_Cytosol

--

p70

p71

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
979.625, 464.5
23.62835360773204, 28.932677887018826

MAL: SOCS-1

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

p70

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1428.0, 439.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019395 e5 e27

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c37 : 1
stoichiometry:c3 : 1

m3962*m11*0.1

nodelay

--

true

0

false

PMID: 17621314, 17048703, 11432202, 16807108 Although nearly all TLRs recruit MyD88, only some recruit Mal, TRAM and TRIF, giving rise to specificity in signalling. PMID: 17621314, 7848516 sTLRs compete with TLR agonists and are highly effective in the first line of negative regulation, as they directly attenuate TLR signalling and therefore prevent acute inflammatory responses.

Go back
666.0, 196.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042032 MO000019397

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m155701*m3964*0.1

nodelay

--

true

0

false

PMID: 17621314, 16230348 Upon stimulation with PGN, MALP-2 and Pam3CSK-4 (ligands of TLR-2), cells displayed an enhanced activation and expression of NF-kappaB, TNF-alpha, IL-1beta and IL-8.

Go back
1037.0, 885.0
21.0, 21.0

p100

p100

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016591 e129

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c326 : 1
stoichiometry:c327 : 1
stoichiometry:c328 : 1

m1585*m136*0.1

nodelay

--

true

0

false

PMID: 17621314, 10385526, 11390377 LIND has been identified as an LPS-inducible A20-binding inhibitor of NFkappa-B and shares sequence homology to A20-binding inhibitor of NF-kappaB activation (ABIN)?1 and ABIN-2.

Go back
1102.0, 1614.0
27.0, 27.0

p101

p101

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c331 : 1
stoichiometry:c330 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 10385526, 11390377 LIND has been identified as an LPS-inducible A20-binding inhibitor of NFkappa-B and shares sequence homology to A20-binding inhibitor of NF-kappaB activation (ABIN)?1 and ABIN-2.

Go back
898.0, 488.0
25.0, 25.0

p102

p102

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e133 e135

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c334 : 1
stoichiometry:c335 : 1
stoichiometry:c337 : 1
stoichiometry:c336 : 1

m1572*m140*m142*0.1

nodelay

--

true

0

false

PMID: 17621314, 16424162 Flightless I homolog (Fliih), primarily expressed in the cytoplasm, was identified as a MyD88 interacting partner in murine macrophages stimulated with lipid A.

Go back
1132.0, 348.0
23.0, 23.0

p103

p103

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016573 e134

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c339 : 1
stoichiometry:c341 : 1
stoichiometry:c342 : 1
stoichiometry:c340 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 17621314, 16424162 Co-immunoprecipitation studies using HEK-293T cells expressing TLR-4 showed that Fliih directly interferes with the interaction of MyD88 and TLR-4 upon LPS stimulation.

Go back
1076.0, 760.0
23.0, 23.0

p104

p104

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e137 MO000000212

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c343 : 1
stoichiometry:c344 : 1
stoichiometry:c345 : 1

m144*m183*0.1

nodelay

--

true

0

false

PMID: 17621314 Further investigations using RAW cells overexpressing FLN29 showed an interaction with endogenous TRAF-6.

Go back
951.0, 783.0
25.0, 25.0

p105

p105

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e138 MO000016882

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c349 : 1
stoichiometry:c351 : 1
stoichiometry:c350 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 16221674 Mashima et al., found FLN29 overexpression in macrophage RAW cells stimulated with LPS caused a significant decrease in TNF-alpha and nitric oxide activation and production.

Go back
383.0, 205.0
23.0, 23.0

p106

p106

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e140

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c352 : 1
stoichiometry:c353 : 1
stoichiometry:c354 : 1

m3964*m147*0.1

nodelay

--

true

0

false

PMID: 17621314, 16230348 Upon stimulation with PGN, MALP-2 and Pam3CSK-4 (ligands of TLR-2), cells displayed an enhanced activation and expression of NF-kappaB, TNF-alpha, IL-1beta and IL-8.

Go back
327.0, 209.0
24.0, 24.0

p107

p107

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e142 MO000019397

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c355 : 1
stoichiometry:c357 : 1
stoichiometry:c356 : 1

m149*m3964*0.1

nodelay

--

true

0

false

PMID: 17621314, 16230348 Upon stimulation with PGN, MALP-2 and Pam3CSK-4 (ligands of TLR-2), cells displayed an enhanced activation and expression of NF-kappaB, TNF-alpha, IL-1beta and IL-8.

Go back
874.0, 1210.0
27.0, 27.0

p108

p108

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e25 MO000041169

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c358 : 1
stoichiometry:c360 : 1
stoichiometry:c367 : 1
stoichiometry:c359 : 1

m16910*m30*0.1

nodelay

--

true

0

false

PMID: 17621314, 16230348 Upon stimulation with PGN, MALP-2 and Pam3CSK-4 (ligands of TLR-2), cells displayed an enhanced activation and expression of NF-kappaB, TNF-alpha, IL-1beta and IL-8. PMID: 17621314, 16230348 Yoshida et al. identified that CYLD is induced through recognition of TLR-2 ligands during bacterial infection, and is able to inhibit activation of both NF-kB and MAPK p38, leading to the subsequent inhibition of pro-inflammatory cytokines through a negative-feedback mechanism. .

Go back
1012.0, 1578.0
25.0, 25.0

p109

p109

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearBody

--

e25 e33

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c493 : 1
stoichiometry:c361 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17621314, 16230348 Upon stimulation with PGN, MALP-2 and Pam3CSK-4 (ligands of TLR-2), cells displayed an enhanced activation and expression of NF-kappaB, TNF-alpha, IL-1beta and IL-8. PMID: 17621314, 11986301 sTLR-2 was found to inhibit IL-8 and tumour necrosis factor (TNF) through the direct interaction with co-receptor sCD14 following stimulation with bacterial lipopeptide.

Go back
705.0, 386.0
26.0, 26.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000068831

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m29*m43675*0.1

nodelay

--

true

0

false

PMID: 17621314, 12447442, 12447441 Mal plays a critical role in host response as demonstrated by the total absence of pro-inflammatory cytokine production during either TLR-2 or TLR-4 signalling.

Go back
695.0, 1689.0
23.0, 23.0

p110

p110

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e25

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c364 : 1
stoichiometry:c363 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17621314, 16230348 Yoshida et al. identified that CYLD is induced through recognition of TLR-2 ligands during bacterial infection, and is able to inhibit activation of both NF-kB and MAPK p38, leading to the subsequent inhibition of pro-inflammatory cytokines through a negative-feedback mechanism. .

Go back
687.0, 1395.0
25.0, 25.0

p111

p111

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e144

MO000041169

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c366 : 1
stoichiometry:c365 : 1

m151*0.1

nodelay

--

true

0

false

PMID: 17621314, 16230348 Yoshida et al. identified that CYLD is induced through recognition of TLR-2 ligands during bacterial infection, and is able to inhibit activation of both NF-kB and MAPK p38, leading to the subsequent inhibition of pro-inflammatory cytokines through a negative-feedback mechanism. .

Go back
1275.0, 1475.0
25.0, 25.0

p112

p112

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000077 MO000041169 e25

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c368 : 1
stoichiometry:c370 : 1
stoichiometry:c371 : 1
stoichiometry:c369 : 1

m69*m30*0.1

nodelay

--

true

0

false

Go back
879.0, 895.0
25.0, 25.0

p113

p113

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000041169

e145

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c372 : 1
stoichiometry:c373 : 1
stoichiometry:c374 : 1

m183*m19042*0.1

nodelay

--

true

0

false

PMID: 17621314 Further co-immunoprecipitation studies demonstrated interactions of CYLD with TRAF-6 and TRAF-7, and colocalization studies confirmed this finding.

Go back
731.0, 1115.0
25.0, 25.0

p114

p114

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000064816 MO000041169

e146

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c375 : 1
stoichiometry:c376 : 1
stoichiometry:c377 : 1

m39686*m19042*0.1

nodelay

--

true

0

false

PMID: 17621314 Further co-immunoprecipitation studies demonstrated interactions of CYLD with TRAF-6 and TRAF-7, and colocalization studies confirmed this finding.

Go back
1210.0, 1678.0
27.0, 27.0

p115

p115

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000077 e147

e148

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c378 : 1
stoichiometry:c379 : 1
stoichiometry:c380 : 1

m69*m154*0.1

nodelay

--

true

0

false

PMID: 17621314, 10627275, 12184814 Eleven mammalian DUSPs have been identified to contain an MAPK binding domain and of those DUSP-1 and DUSP-2 (also known as phosphatase of activated cells-1 (PAC-1)) are most closely affiliated with immune cells.

Go back
1195.0, 1415.0
25.0, 25.0

p116

p116

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000077 e149 e160

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c381 : 1
stoichiometry:c388 : 1
stoichiometry:c189 : 1
stoichiometry:c382 : 1

m69*m167*0.1

nodelay

--

true

0

false

PMID: 17621314, 12444149, 15590669, 15485842 DUSP-1 overexpression in vitro using macrophages was shown to inhibit phosphorylation of MAPK resulting in the decreased expression of pro-inflammatory cytokines TNF-alpha and IL-6 in response to various TLR ligands.

Go back
1020.0, 1528.0
23.0, 23.0

p117

p117

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c385 : 1
stoichiometry:c384 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17621314, 12444149, 15590669, 15485842 DUSP-1 overexpression in vitro using macrophages was shown to inhibit phosphorylation of MAPK resulting in the decreased expression of pro-inflammatory cytokines TNF-alpha and IL-6 in response to various TLR ligands.

Go back
1020.0, 1492.0
23.0, 23.0

p118

p118

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c386 : 1
stoichiometry:c387 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17621314, 12444149, 15590669, 15485842 DUSP-1 overexpression in vitro using macrophages was shown to inhibit phosphorylation of MAPK resulting in the decreased expression of pro-inflammatory cytokines TNF-alpha and IL-6 in response to various TLR ligands.

Go back
779.0, 875.0
25.0, 25.0

p119

p119

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e151 e150

e152

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c389 : 1
stoichiometry:c390 : 1
stoichiometry:c391 : 1

m158*m157*0.1

nodelay

--

true

0

false

PMID: 17621314 Furthermore, co-immunoprecipitation studies showed a physical interaction between DUSP-2 and p38, Jnk and Erk.

Go back
1427.0, 314.0
27.0, 27.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e26 e5

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m31*m11*0.1

nodelay

--

true

0

false

PMID: 17621314, 7848516 sTLRs compete with TLR agonists and are highly effective in the first line of negative regulation, as they directly attenuate TLR signalling and therefore prevent acute inflammatory responses.

Go back
715.0, 931.0
25.0, 25.0

p120

p120

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e150 MO000000011

e153

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c392 : 1
stoichiometry:c393 : 1
stoichiometry:c394 : 1

m157*m6*0.1

nodelay

--

true

0

false

PMID: 17621314 Furthermore, co-immunoprecipitation studies showed a physical interaction between DUSP-2 and p38, Jnk and Erk.

Go back
715.0, 823.0
25.0, 25.0

p121

p121

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e155 e150

e154

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c396 : 1
stoichiometry:c397 : 1
stoichiometry:c395 : 1

m162*m157*0.1

nodelay

--

true

0

false

PMID: 17621314 Furthermore, co-immunoprecipitation studies showed a physical interaction between DUSP-2 and p38, Jnk and Erk.

Go back
862.0, 830.0
27.0, 27.0

p122

p122

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e151 e160 e158 e171

e156

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c383 : 1
stoichiometry:c400 : 1
stoichiometry:c404 : 1
stoichiometry:c469 : 1
stoichiometry:c399 : 1

m158*m167*m178*0.1

nodelay

--

true

0

false

PMID: 17621314 DUSP-2/PAC-1 is primarily known for its role in inactivating p38 and ERK in vitro.

Go back
780.0, 1020.0
23.0, 23.0

p123

p123

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e158 e160

e157

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c402 : 1
stoichiometry:c405 : 1
stoichiometry:c398 : 1
stoichiometry:c403 : 1

m6*m167*0.1

nodelay

--

true

0

false

PMID: 17621314 DUSP-2/PAC-1 is primarily known for its role in inactivating p38 and ERK in vitro.

Go back
835.0, 791.0
25.0, 25.0

p124

p124

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e151 e25 MO000041169

e156

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c406 : 1
stoichiometry:c408 : 1
stoichiometry:c409 : 1
stoichiometry:c407 : 1

m158*m30*0.1

nodelay

--

true

0

false

PMID: 17621314 Co-immunoprecipitation studies using the HEK-293-TLR-2 cells showed that CYLD acted as a negative regulator of the MAPK p38 pathway, as CYLD inhibited PGN-induced phosphorylation of IkappaB-alpha, MKK3/6 and p38.

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939.0, 907.0
25.0, 25.0

p125

p125

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e159 e95 e161

e160

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c410 : 1
stoichiometry:c411 : 1
stoichiometry:c416 : 1
stoichiometry:c412 : 1

m166*m102*0.1

nodelay

--

true

0

false

PMID: 17621314, 17157040 It was shown through a series of mutational analyses that SHP-2 could bind specifically to the N terminus of TBK-1 to exert inhibitory effects on downstream signalling, as the binding of SHP-2 to TBK-1 suppresses TBK-1-mediated phosphorylation and subsequent cytokine production.

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884.0, 628.0
24.0, 24.0

p126

p126

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016886 e159

e161

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c414 : 1
stoichiometry:c415 : 1

m1807*m166*0.1

nodelay

--

true

0

false

PMID: 17621314, 17157040 It was shown through a series of mutational analyses that SHP-2 could bind specifically to the N terminus of TBK-1 to exert inhibitory effects on downstream signalling, as the binding of SHP-2 to TBK-1 suppresses TBK-1-mediated phosphorylation and subsequent cytokine production.

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728.0, 628.0
23.0, 23.0

p127

p127

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e21 MO000016886

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c417 : 1
stoichiometry:c421 : 1
stoichiometry:c423 : 1
stoichiometry:c418 : 1

m977*m25*0.1

nodelay

--

true

0

false

PMID: 17621314 IRF-3 activation was also shown to be inhibited in the presence of SHP-2 as RAW cells transfected with increasing doses of SHP-2 dose dependently decreased IRF-3 activation.

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743.0, 679.0
26.0, 26.0

p128

p128

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e23 MO000016886

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c419 : 1
stoichiometry:c422 : 1
stoichiometry:c424 : 1
stoichiometry:c420 : 1

m977*m28*0.1

nodelay

--

true

0

false

PMID: 17621314 IRF-3 activation was also shown to be inhibited in the presence of SHP-2 as RAW cells transfected with increasing doses of SHP-2 dose dependently decreased IRF-3 activation.

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659.0, 1415.0
25.0, 25.0

p129

p129

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 MO000041456 e163

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c427 : 1
stoichiometry:c436 : 1
stoichiometry:c124 : 1

m93217*m19324*0.1

nodelay

--

true

0

false

PMID: 17621314, 17157040 SH-2 containing protein tyrosine phosphatase-2 (SHP-2) has been implicated as a negative regulator of IFN-beta production through TLR-3 and TLR-4-mediated signalling. PMID: 17621314 This results in the inhibition of IRF-3 in response to TLR-3 and TLR-4.

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497.0, 162.0
26.0, 26.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e31 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c39 : 1

m36*m35*0.1

nodelay

--

true

0

false

PMID: 17621314, 11986301 sTLR-2 was found to inhibit IL-8 and tumour necrosis factor (TNF) through the direct interaction with co-receptor sCD14 following stimulation with bacterial lipopeptide.

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515.0, 679.0
25.0, 25.0

p130

p130

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e162 MO000041456

e163

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c428 : 1
stoichiometry:c429 : 1
stoichiometry:c430 : 1

m169*m19324*0.1

nodelay

--

true

0

false

PMID: 17621314, 16699525 Peptidyl-prolyl isomerase (Pin)-1, consisting of a short N-terminal domain and a catalytic C-terminal domain is only able to directly interact with IRF-3 after IRF-3 has been phosphorylated on Ser 339.

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451.0, 739.0
25.0, 25.0

p131

p131

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e163

e164

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c431 : 1
stoichiometry:c432 : 1

m170*0.1

nodelay

--

true

0

false

PMID: 17621314 The mechanism involved in negatively regulating IRF-3 is achieved by Pin-1 binding directly to IRF-3 leading to its polyubiquitination and subsequent proteosomal degradation.

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599.0, 739.0
25.0, 25.0

p132

p132

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e164

e67 e162

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c433 : 1
stoichiometry:c434 : 1
stoichiometry:c435 : 1

m171*0.1

nodelay

--

true

0

false

PMID: 17621314 The mechanism involved in negatively regulating IRF-3 is achieved by Pin-1 binding directly to IRF-3 leading to its polyubiquitination and subsequent proteosomal degradation.

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291.0, 1107.0
25.0, 25.0

p133

p133

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e165 e162

e166

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c437 : 1
stoichiometry:c439 : 1
stoichiometry:c438 : 1

m172*m169*0.1

nodelay

--

true

0

false

PMID: 17621314, 14690596 Through mutational analyses of critical binding sites on the p65 subunit, the Thr254-Pro binding site was identified as critical for Pin-1 interactions.

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537.0, 1441.0
23.0, 23.0

p134

p134

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e167

e168 e162

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c442 : 1
stoichiometry:c443 : 1
stoichiometry:c444 : 1

m174*0.1

nodelay

--

true

0

false

PMID: 17621314 Without interactions at Thr-254, p65 cannot be phosphorylated, resulting in the p65 protein being unstable for the subsequent translocation into the nucleus and its targeting for proteosomal degradation.

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323.0, 1175.0
25.0, 25.0

p135

p135

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e166

e167

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c440 : 1
stoichiometry:c441 : 1

m173*0.1

nodelay

--

true

0

false

PMID: 17621314 Without interactions at Thr-254, p65 cannot be phosphorylated, resulting in the p65 protein being unstable for the subsequent translocation into the nucleus and its targeting for proteosomal degradation.

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774.0, 1494.0
27.0, 27.0

p136

p136

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e168

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c445 : 1
stoichiometry:c446 : 1

m175*0.1

nodelay

--

true

0

false

PMID: 17621314 Without interactions at Thr-254, p65 cannot be phosphorylated, resulting in the p65 protein being unstable for the subsequent translocation into the nucleus and its targeting for proteosomal degradation.

Go back
443.0, 1107.0
25.0, 25.0

p137

p137

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e165 MO000017004

e169

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c447 : 1
stoichiometry:c449 : 1
stoichiometry:c448 : 1

m172*m1906*0.1

nodelay

--

true

0

false

PMID: 17621314 Further studies looking at the negative regulatory effects of SOCS-1 on p65 showed that SOCS-1 binds in an area of close proximity to that of Pin-1.

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503.0, 1163.0
25.0, 25.0

p138

p138

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e169 e166

e170 MO000017004

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c450 : 1
stoichiometry:c455 : 1
stoichiometry:c451 : 1
stoichiometry:c452 : 1

m176*0.1

nodelay

--

true

0

false

PMID: 17621314 As SOCS-1 is known to polyubiquitination p65 and suppress NF-kappaB activation, Ryo et al. wanted to investigate if SOCS-1 had any effect on the stability and ubiquitination of p65 in the presence of Pin-1. PMID: 17621314 Overexpression studies both in vitro and in vivo of SOCS-1, SOCS-1 mutant and Pin-1 showed that Pin-1 protects p65 from SOCS-1 destabilization through blocking its degradation, and was also able to inhibit SOCS-1-mediated ubiquitination.

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503.0, 1263.0
26.0, 26.0

p139

p139

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e170 e166

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c453 : 1
stoichiometry:c456 : 1
stoichiometry:c454 : 1

m177*0.1

nodelay

--

true

0

false

PMID: 17621314 Overexpression studies both in vitro and in vivo of SOCS-1, SOCS-1 mutant and Pin-1 showed that Pin-1 protects p65 from SOCS-1 destabilization through blocking its degradation, and was also able to inhibit SOCS-1-mediated ubiquitination.

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432.0, 165.0
27.0, 27.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e32 e29

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m37*m34*0.1

nodelay

--

true

0

false

PMID: 17621314, 11986301 sTLR-2 was found to inhibit IL-8 and tumour necrosis factor (TNF) through the direct interaction with co-receptor sCD14 following stimulation with bacterial lipopeptide.

Go back
831.0, 735.0
25.0, 25.0

p140

p140

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e155 e160

e172

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c458 : 1
stoichiometry:c470 : 1
stoichiometry:c459 : 1

m162*m167*0.1

nodelay

--

true

0

false

PMID: 17621314 Results indicated that phosphorylation of Jnk and p38 was significantly reduced in Ubc13f l/f l Cd19 Cre B cells upon stimulation with anti-IgM compared to wild type.

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1015.0, 623.0
25.0, 25.0

p141

p141

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e173 e171

e174

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c460 : 1
stoichiometry:c462 : 1
stoichiometry:c461 : 1

m180*m178*0.1

nodelay

--

true

0

false

PMID: 17621314, 11057907 Ubc13 E2 ubiquitin-conjugating enzyme is known to olyubiquitinate TRAF-2 and TRAF-6 through their attached K63 polyubiquitin chains.

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875.0, 1111.0
25.0, 25.0

p142

p142

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016661 e160

e175

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c463 : 1
stoichiometry:c465 : 1
stoichiometry:c464 : 1

m1637*m167*0.1

nodelay

--

true

0

false

PMID: 17621314 TRAF-6 and TRAF-2 are involved in the ubiquitination of downstream adaptor molecule NF-kappaB essential modulator (NEMO) in response to antigen receptor induced NF-kappaB activation.

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876.0, 1060.0
23.0, 23.0

p143

p143

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016661 e173

e175

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c466 : 1
stoichiometry:c468 : 1
stoichiometry:c467 : 1

m1637*m180*0.1

nodelay

--

true

0

false

PMID: 17621314 TRAF-6 and TRAF-2 are involved in the ubiquitination of downstream adaptor molecule NF-kappaB essential modulator (NEMO) in response to antigen receptor induced NF-kappaB activation.

Go back
915.0, 1091.0
25.0, 25.0

p144

p144

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016661 e64 e171

e176

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c471 : 1
stoichiometry:c473 : 1
stoichiometry:c474 : 1
stoichiometry:c472 : 1

m1637*m70*m178*0.1

nodelay

--

true

0

false

PMID: 17621314 Phosphorylation of signalling adaptor NEMO in vitro has been suggested to be dependent on Ubc13 under IL-1beta induction.

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1196.0, 204.0
23.0, 23.0

p145

p145

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e178 e177

e179

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c475 : 1
stoichiometry:c476 : 1
stoichiometry:c477 : 1

m190*m189*0.1

nodelay

--

true

0

false

PMID: 17621314, 12974773 Studies have revealed that mycobacteria directly interact with DC-SIGN in order to regulate TLR-4 mediated signalling responses in DCs. PMID: 17621314, 12974773 Specifically the ligand responsible for modulating TLR-4 responses is ManLAM, a cell-wall component of Mycobacterium tuberculosis. The mechanism by which ManLAM negatively regulates TLR-4 is by binding to DC-SIGN, impairing LPS-induced DC maturation and the marked increase of IL-10 that has known immunosuppressive properties.

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960.0, 76.0
24.0, 24.0

p146

p146

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000016882 e179

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c478 : 1
stoichiometry:c479 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 12974773 Specifically the ligand responsible for modulating TLR-4 responses is ManLAM, a cell-wall component of Mycobacterium tuberculosis. The mechanism by which ManLAM negatively regulates TLR-4 is by binding to DC-SIGN, impairing LPS-induced DC maturation and the marked increase of IL-10 that has known immunosuppressive properties.

Go back
592.0, 1924.0
23.0, 23.0

p147

p147

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e180 e179

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c481 : 1
stoichiometry:c482 : 1
stoichiometry:c480 : 1

m192*m191*0.1

nodelay

--

true

0

false

PMID: 17621314, 12974773 Specifically the ligand responsible for modulating TLR-4 responses is ManLAM, a cell-wall component of Mycobacterium tuberculosis. The mechanism by which ManLAM negatively regulates TLR-4 is by binding to DC-SIGN, impairing LPS-induced DC maturation and the marked increase of IL-10 that has known immunosuppressive properties.

Go back
1275.0, 1819.0
25.0, 25.0

p148

p148

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e181 e179

e182

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c483 : 1
stoichiometry:c485 : 1
stoichiometry:c484 : 1

m193*m191*0.1

nodelay

--

true

0

false

--

Go back
1170.0, 1754.0
27.0, 27.0

p149

p149

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e66 e182

e183

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c486 : 1
stoichiometry:c488 : 1
stoichiometry:c487 : 1

m72*m194*0.1

nodelay

--

true

0

false

PMID: 17621314, 17462920 ManLAM binds DC-SIGN in human DCs modulating TLR signalling by activating the serine and threonine kinase Raf-1, allowing the subsequent phosphorylation and acetylation of the p65 unit of NF-kappaB. PMID: 17621314, 17462920 Further investigations revealed that the specific phosphorylation event of Ser 276 on p65 is critical for Raf-1-dependent acetylation and the prolonged transcription of the IL-10 gene.

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1427.0, 486.0
27.0, 27.0

p15

p15

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

e11

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17621314, 12538665 Subsequent studies showed the preferential recruitment of MyD88s-MyD88 heterodimers in favour of MyD88 homodimers, which allowed the recruitment of IRAK-1 resulting in the ablation of IRAK-1 phosphorylation.

Go back
1169.0, 1893.0
30.0, 30.0

p150

p150

cso30:i:ME_Acetylation

cso30:i:CC_Cytosol

--

e183

e184

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c489 : 1
stoichiometry:c490 : 1

m195*0.1

nodelay

--

true

0

false

PMID: 17621314, 17462920 ManLAM binds DC-SIGN in human DCs modulating TLR signalling by activating the serine and threonine kinase Raf-1, allowing the subsequent phosphorylation and acetylation of the p65 unit of NF-kappaB. PMID: 17621314, 17462920 Further investigations revealed that the specific phosphorylation event of Ser 276 on p65 is critical for Raf-1-dependent acetylation and the prolonged transcription of the IL-10 gene.

Go back
911.0, 1835.0
25.0, 25.0

p151

p151

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e184

e180

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c492 : 1
stoichiometry:c491 : 1

m196*0.1

nodelay

--

true

0

false

PMID: 17621314 Two consequences of p65 acetylation are, first, the increased expression of IL-10 and, second, there is a prolonged activation of p65 and therefore prolonged NF-kappaB activity allowing increased transcription of the IL-10 gene.

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326.0, 1422.0
27.0, 27.0

p152

p152

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e185 MO000016964

e186

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c494 : 1
stoichiometry:c495 : 1
stoichiometry:c496 : 1

m5*m1873*0.1

nodelay

--

true

0

false

PMID: 17621314, 16052631 Takeshita et al., using cytosolic components of nicotinamide adenine dinucleotide phosphate oxidase, namely p47phox, p67phox, p40phox and rac2, described the interaction between p47phox and TRAF-4 resulting in the suppression of TLR-mediated signalling through TRAF-6 and TRIF.

Go back
328.0, 1512.0
23.0, 23.0

p153

p153

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016964 e185 MO000000212 MO000041125 MO000000213

e187

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c498 : 1
stoichiometry:c499 : 1
stoichiometry:c500 : 1
stoichiometry:c501 : 1
stoichiometry:c502 : 1
stoichiometry:c497 : 1

m1873*m5*m183*m18998*m184*0.1

nodelay

--

true

0

false

PMID: 17621314, 16052631 Following this observation, co-immunoprecipitation studies confirmed a physical interaction with not only p47phox, but also with TRAF-6, TRIF and IRAK-1, suggesting that TRAF-4 is able to form complexes with these molecules. PMID: 17621314, 16052631 Possible mechanisms suggested by Takeshita et al., for the negative regulation of TLR-mediated signalling by NADH oxidase is via a novel TRAF?TRAF dimerization, through the interaction of p47phox with TRAF-4, TRAF-6 and TRIF.

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721.0, 1581.0
22.0, 22.0

p154

p154

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e187

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c505 : 1
stoichiometry:c504 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17621314 Furthermore, overexpression studies in HEK-293 cells cotransfected with TLR-2, TLR-3, TLR-4 and TLR-9, stimulated with their appropriate ligands and increasing doses of TRAF-4, resulted in luciferase analysis showing a decrease in activation of both NF-kappaB and the IFN-beta promoter, but not in TNF-alpha receptor-mediated signalling.

Go back
1237.0, 593.0
27.0, 27.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e34 MO000039077 e37

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c50 : 1
stoichiometry:c56 : 1
stoichiometry:c49 : 1

m184*m39*m17258*0.1

nodelay

--

true

0

false

PMID: 17621314, 12538665 Subsequent studies showed the preferential recruitment of MyD88s-MyD88 heterodimers in favour of MyD88 homodimers, which allowed the recruitment of IRAK-1 resulting in the ablation of IRAK-1 phosphorylation. PMID: 17621314, 12885415 This phosphorylation is normally mediated by IRAK-4, but in the presence of MyD88s, IRAK-4 is not recruited to the signalling complex.

Go back
1235.0, 538.0
28.0, 28.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 e11

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m41*m13*0.1

nodelay

--

true

0

false

PMID: 17621314, 12538665 Subsequent studies showed the preferential recruitment of MyD88s-MyD88 heterodimers in favour of MyD88 homodimers, which allowed the recruitment of IRAK-1 resulting in the ablation of IRAK-1 phosphorylation.

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1426.0, 822.0
25.0, 25.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e35 e39

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c186 : 1
stoichiometry:c55 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17621314, 12885415 This phosphorylation is normally mediated by IRAK-4, but in the presence of MyD88s, IRAK-4 is not recruited to the signalling complex. PMID: 17621314, 11751856 Tollip also interacts with IRAK-1 leading to a decrease in IRAK-1 autophosphorylation and NF-kappaB activation.

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1266.0, 758.0
27.0, 27.0

p19

p19

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e38 MO000016569

e40 e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c63 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17621314, 12150927 It was also discovered in vitro that IRAK-M prevents dissociation of IRAK-1/IRAK-4 from the MyD88 receptor complex, therefore inhibiting the association of IRAK-1 with TRAF-6.

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1237.0, 488.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000016573

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 17621314, 17048703, 11432202, 16807108 Although nearly all TLRs recruit MyD88, only some recruit Mal, TRAM and TRIF, giving rise to specificity in signalling.

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1140.0, 828.0
24.0, 24.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e40 e138

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c60 : 1
stoichiometry:c346 : 1
stoichiometry:c61 : 1

m183*m45*0.1

nodelay

--

true

0

false

PMID: 17621314, 12150927 It was also discovered in vitro that IRAK-M prevents dissociation of IRAK-1/IRAK-4 from the MyD88 receptor complex, therefore inhibiting the association of IRAK-1 with TRAF-6. PMID: 17621314 The exact mechanism of how TRAF-6 is targeted for the negative regulation of TLR-mediated signalling by FLN29 is undefined, however, it is suggested that FLN29 may inhibit downstream of TRAF-6 based on current findings.

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1226.0, 344.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 MO000044794

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c68 : 1

m43675*m22464*0.1

nodelay

--

true

0

false

PMID: 17621314, 15004556 This study showed a direct interaction between ST2L and MyD88 and Mal, but not TRIF or IRAK.

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1267.0, 341.0
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044794 MO000016573

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c69 : 1

m22464*m1572*0.1

nodelay

--

true

0

false

PMID: 17621314, 15004556 This study showed a direct interaction between ST2L and MyD88 and Mal, but not TRIF or IRAK.

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767.0, 2059.0
25.0, 25.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000044786 MO000018424

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m22456*m3062*0.1

nodelay

--

true

0

false

PMID: 17621314, 11359817 sST2 binds to macrophages through a putative ST2 receptor.

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934.0, 1788.0
25.0, 25.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44 MO000016882

G010961

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c73 : 1

m49*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 15557191, 11359817 Following the addition of sST2 to LPS-stimulated macrophages, there was significant suppression of mRNA expression of TLR-1 and TLR-4, leading to reduced pro-inflammatory cytokine production.

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982.0, 1776.0
25.0, 25.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44 MO000016882 MO000017443

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c313 : 1
stoichiometry:c74 : 1

m49*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 15557191, 11359817 Following the addition of sST2 to LPS-stimulated macrophages, there was significant suppression of mRNA expression of TLR-1 and TLR-4, leading to reduced pro-inflammatory cytokine production. PMID: 17621314, 15623538 TGF-beta1 inhibits TLR-4 expression by suppressing LPS-mediated responses and is also able to induce MyD88 degradation through interactions via its DD.

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1095.0, 1659.0
25.0, 25.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c79 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 14993616 LPS stimulation in mouse models caused an increase in SIGIRR expression in various tissues, implicating its importance in the regulation of inflammatory responses.

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1418.0, 914.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e47 e46

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m65*m64*0.1

nodelay

--

true

0

false

PMID: 17621314, 12925853 Similarly to ST2, this suggests that SIGIRR acts on the MyD88-dependent pathway as SIGIRR has been shown to form complexes with IL-1 receptor complex molecules, IRAK and TRAF-6 upon IL-1 stimulation in vitro.

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1266.0, 964.0
24.0, 24.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e87

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c176 : 1
stoichiometry:c85 : 1

m1572*m94*0.1

nodelay

--

true

0

false

PMID: 17621314, 12925853 Similarly to ST2, this suggests that SIGIRR acts on the MyD88-dependent pathway as SIGIRR has been shown to form complexes with IL-1 receptor complex molecules, IRAK and TRAF-6 upon IL-1 stimulation in vitro.

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1205.0, 1010.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000039077 MO000039097

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c90 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m67*m17258*m17273*0.1

nodelay

--

true

0

false

PMID: 17621314, 12925853 Similarly to ST2, this suggests that SIGIRR acts on the MyD88-dependent pathway as SIGIRR has been shown to form complexes with IL-1 receptor complex molecules, IRAK and TRAF-6 upon IL-1 stimulation in vitro. PMID: 17621314, 10854325 Toll-interacting protein (Tollip) is a protein which interacts with the IL-1R accessory protein and is responsible for bringing IRAK to the receptor complex.

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1037.0, 190.0
26.0, 26.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000018132

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m155666*m2828*0.1

nodelay

--

true

0

false

PMID: 17621314, 15557191 The mechanism involved in sTLR-4 inhibition to date is not fully understood, however, it has been hypothesized that sTLR-4 may block the interaction between TLR-4 and its co-receptors MD2 and CD14, leading to the termination of signalling.

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1242.0, 1054.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000000212 e138

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c347 : 1
stoichiometry:c93 : 1

m68*m183*0.1

nodelay

--

true

0

false

PMID: 17621314, 12925853 Similarly to ST2, this suggests that SIGIRR acts on the MyD88-dependent pathway as SIGIRR has been shown to form complexes with IL-1 receptor complex molecules, IRAK and TRAF-6 upon IL-1 stimulation in vitro. PMID: 17621314 The exact mechanism of how TRAF-6 is targeted for the negative regulation of TLR-mediated signalling by FLN29 is undefined, however, it is suggested that FLN29 may inhibit downstream of TRAF-6 based on current findings.

Go back
1395.0, 1163.0
25.0, 25.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 MO000066718

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m70*m41575*0.1

nodelay

--

true

0

false

PMID: 17621314, 12925853 Similarly to ST2, this suggests that SIGIRR acts on the MyD88-dependent pathway as SIGIRR has been shown to form complexes with IL-1 receptor complex molecules, IRAK and TRAF-6 upon IL-1 stimulation in vitro.

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1125.0, 1210.0
25.0, 25.0

p32

p32

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e64 e65 e70 e116 e117 e132

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c113 : 1
stoichiometry:c273 : 1
stoichiometry:c278 : 1
stoichiometry:c333 : 1
stoichiometry:c98 : 1

m16910*m70*0.1

nodelay

--

true

0

false

PMID: 17621314, 14715412 It was also shown that the overexpression of SIGIRR in bone marrow-derived DCs leads to the inhibition of IL-1 and -18-mediated activation of NF-kappaB. PMID: 17621314, 15852007 This was also observed in vivo as NF-kappaB activation was downregulated. PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha. PMID: 17621314, 15125834, 15173580 beta-arrestin-1 and beta-arrestin-2 have recently been identified as negative regulators of TLR-IL-1R-mediated signalling pathways augmenting NF-kappaB activation.

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1079.0, 1367.0
25.0, 25.0

p33

p33

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000000254 e72

e66 e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c117 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m208*0.1

nodelay

--

true

0

false

PMID: 17621314, 15589175 After initial activation of the TLR signalling pathways, TRAILR appears to stabilize IkappaB-alpha resulting in the decrease of nuclear translocation of NF-kappaB. PMID: 17621314, 15334086 A20, was originally associated with TNF mediated NF-kappaB activation, but has also been identified as a cysteine protease de-ubiquitylating protein able to prevent TLR signalling via TRAF-6. Ablation of TLR-mediated signalling is the result of the cleavage of a polyubiquitin chain in TRAF-6 that in turn inhibits NFkappaB translocation to the nucleus.

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1020.0, 1404.0
23.0, 23.0

p34

p34

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e66

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17621314, 15334086 A20, was originally associated with TNF mediated NF-kappaB activation, but has also been identified as a cysteine protease de-ubiquitylating protein able to prevent TLR signalling via TRAF-6. Ablation of TLR-mediated signalling is the result of the cleavage of a polyubiquitin chain in TRAF-6 that in turn inhibits NFkappaB translocation to the nucleus.

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938.0, 1515.0
24.0, 24.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 17621314, 16426569 This study showed that sST2 suppressed the production of IL-6, IL-1beta and TNF-alpha by binding to THP-1 cells, in turn reducing the binding affinity of NF-kappaB to the IL-6 promoter, leading to the degradation of IkappaB following LPS stimulation.

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938.0, 1555.0
24.0, 24.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68 e33

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c146 : 1
stoichiometry:c123 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17621314, 16426569 This study showed that sST2 suppressed the production of IL-6, IL-1beta and TNF-alpha by binding to THP-1 cells, in turn reducing the binding affinity of NF-kappaB to the IL-6 promoter, leading to the degradation of IkappaB following LPS stimulation. PMID: 17621314, 11986301 sTLR-2 was found to inhibit IL-8 and tumour necrosis factor (TNF) through the direct interaction with co-receptor sCD14 following stimulation with bacterial lipopeptide. PMID: 17621314, 16230348 Upon stimulation with PGN, MALP-2 and Pam3CSK-4 (ligands of TLR-2), cells displayed an enhanced activation and expression of NF-kappaB, TNF-alpha, IL-1beta and IL-8.

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960.0, 1596.0
23.0, 23.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c426 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17621314, 16426569 This study showed that sST2 suppressed the production of IL-6, IL-1beta and TNF-alpha by binding to THP-1 cells, in turn reducing the binding affinity of NF-kappaB to the IL-6 promoter, leading to the degradation of IkappaB following LPS stimulation. PMID: 17621314, 16230348 Upon stimulation with PGN, MALP-2 and Pam3CSK-4 (ligands of TLR-2), cells displayed an enhanced activation and expression of NF-kappaB, TNF-alpha, IL-1beta and IL-8.

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1322.0, 176.0
25.0, 25.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e79 MO000016882

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m86*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 11120784 It was demonstrated in mouse models that the presence of sTLR-4 following LPS stimulation inhibited NF-kappaB activation in vitro.

Go back
801.0, 346.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016653 MO000022200

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m1632*m6500*0.1

nodelay

--

true

0

false

PMID: 17621314, 16303092 In order for inhibitory effects to be exerted by RP105, it requires its own coreceptor MD1 before an interaction with the TLR-4/MD2 complex is possible.

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1093.0, 198.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e12 e80

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c38 : 1
stoichiometry:c12 : 1

m15*m14*0.1

nodelay

--

true

0

false

PMID: 17621314, 15557191 The mechanism involved in sTLR-4 inhibition to date is not fully understood, however, it has been hypothesized that sTLR-4 may block the interaction between TLR-4 and its co-receptors MD2 and CD14, leading to the termination of signalling. PMID: 17621314, 15557191 The mechanism involved in sTLR-4 inhibition to date is not fully understood, however, it has been hypothesized that sTLR-4 may block the interaction between TLR-4 and its co-receptors MD2 and CD14, leading to the termination of signalling.

Go back
842.0, 174.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e69 e12 MO000016882

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m75*m14*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 16303092 In order for inhibitory effects to be exerted by RP105, it requires its own coreceptor MD1 before an interaction with the TLR-4/MD2 complex is possible. PMID: 17621314, 16303092 Divanovic et al., found that upon stimulation with LPS, RP105 directly interacts with the TLR-4/MD2 complex sequestering sites available for LPS binding.

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1431.0, 1415.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000043372 e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m21137*m78*0.1

nodelay

--

true

0

false

PMID: 17621314, 15589175 After initial activation of the TLR signalling pathways, TRAILR appears to stabilize IkappaB-alpha resulting in the decrease of nuclear translocation of NF-kappaB.

Go back
968.0, 1452.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e73 e68 e44

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c136 : 1
stoichiometry:c120 : 1

m80*m74*0.1

nodelay

--

true

0

false

PMID: 17621314, 16426569 This study showed that sST2 suppressed the production of IL-6, IL-1beta and TNF-alpha by binding to THP-1 cells, in turn reducing the binding affinity of NF-kappaB to the IL-6 promoter, leading to the degradation of IkappaB following LPS stimulation.

Go back
602.0, 1516.0
25.0, 25.0

p43

p43

cso30:i:ME_Translation

cso30:i:CC_NuclearEnvelopeLumen

--

G010262 e44 e124

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c133 : 1
stoichiometry:c305 : 1
stoichiometry:c127 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 17621314, 16426569 This study showed that sST2 suppressed the production of IL-6, IL-1beta and TNF-alpha by binding to THP-1 cells, in turn reducing the binding affinity of NF-kappaB to the IL-6 promoter, leading to the degradation of IkappaB following LPS stimulation. PMID: 17621314, 16670302 PI3K class I enzymes were shown to affect NF-kappaB activation and IL-12 production, where as the class III PI3Ks were shown to be involved in both NF-kappaB activation as well as the production of IL-6, IL-12 and TNF-alpha. PMID: 17621314, 16670302 In recent studies by Kuo et al., they demonstrated that the class I and class III PI3K enzymes have distinct negative regulatory roles in TLR signalling in response to CpG DNA/ODN.

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574.0, 1560.0
25.0, 25.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e44 e124 e138

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c134 : 1
stoichiometry:c304 : 1
stoichiometry:c348 : 1
stoichiometry:c129 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 17621314, 16426569 This study showed that sST2 suppressed the production of IL-6, IL-1beta and TNF-alpha by binding to THP-1 cells, in turn reducing the binding affinity of NF-kappaB to the IL-6 promoter, leading to the degradation of IkappaB following LPS stimulation. PMID: 17621314, 16670302 PI3K class I enzymes were shown to affect NF-kappaB activation and IL-12 production, where as the class III PI3Ks were shown to be involved in both NF-kappaB activation as well as the production of IL-6, IL-12 and TNF-alpha. PMID: 17621314, 16670302 In recent studies by Kuo et al., they demonstrated that the class I and class III PI3K enzymes have distinct negative regulatory roles in TLR signalling in response to CpG DNA/ODN. PMID: 17621314, 16221674 Mashima et al., found FLN29 overexpression in macrophage RAW cells stimulated with LPS caused a significant decrease in TNF-alpha and nitric oxide activation and production.

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592.0, 1600.0
24.5, 24.5

p45

p45

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e44 G010389

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c425 : 1
stoichiometry:c128 : 1

m93364*0.1

nodelay

--

true

0

false

PMID: 17621314, 16426569 This study showed that sST2 suppressed the production of IL-6, IL-1beta and TNF-alpha by binding to THP-1 cells, in turn reducing the binding affinity of NF-kappaB to the IL-6 promoter, leading to the degradation of IkappaB following LPS stimulation.

Go back
1124.0, 2052.0
23.0, 23.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e76 MO000044786

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m83*m22456*0.1

nodelay

--

true

0

false

Go back
1138.0, 1262.0
26.0, 26.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e77 e116 e117

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c274 : 1
stoichiometry:c280 : 1
stoichiometry:c141 : 1

m16910*m84*0.1

nodelay

--

true

0

false

PMID: 17621314, 16286016 It must be noted that there are conflicting reports on the actions of ST2, as Schmitz et al. recently described that ST2 was a receptor for the recently identified member of the IL-1 family namely IL-33, which exerts its biological effects via ST2 enhancing activation of NF-kappaB and MAPK. PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha.

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1158.0, 1474.0
27.0, 27.0

p48

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000077 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c145 : 1
stoichiometry:c144 : 1

m69*m84*0.1

nodelay

--

true

0

false

PMID: 17621314, 16286016 It must be noted that there are conflicting reports on the actions of ST2, as Schmitz et al. recently described that ST2 was a receptor for the recently identified member of the IL-1 family namely IL-33, which exerts its biological effects via ST2 enhancing activation of NF-kappaB and MAPK.

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1160.0, 1324.0
25.0, 25.0

p49

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e94 e116 e117

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c272 : 1
stoichiometry:c277 : 1
stoichiometry:c151 : 1

m16910*m101*0.1

nodelay

--

true

0

false

PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha.

Go back
1095.0, 387.0
24.0, 24.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m43675*m16*0.1

nodelay

--

true

0

false

PMID: 17621314, 12447442, 12447441 Mal plays a critical role in host response as demonstrated by the total absence of pro-inflammatory cytokine production during either TLR-2 or TLR-4 signalling.

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602.0, 1730.0
27.0, 27.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e75 MO000016882

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c153 : 1

m82*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314 The treatment of cells with LPS resulted in significantly increased levels of SARM proteins, suggesting a mechanism for how SARM is involved in specifically regulating TRIF-dependent TLR-3 and TLR-4 inflammatory esponses through a negative-feedback mechanism.

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615.0, 459.0
24.0, 24.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e28 MO000016882

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c157 : 1

m18998*m33*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314 To date, it is still unclear in regards to the exact mechanism of how SARM inhibits TRIF function, however, it can be hypothesized from finding by Bowie and colleagues, who demonstrated that SARM and TRIF weakly interact in resting cells and upon LPS stimulation, increase in stability possibly preventing the recruitment of downstream effector molecules to TRIF.

Go back
1182.0, 1242.0
25.0, 25.0

p52

p52

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e82 MO000038724 e84 e85 MO000016882 e116 e117

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c168 : 1
stoichiometry:c170 : 1
stoichiometry:c172 : 1
stoichiometry:c275 : 1
stoichiometry:c279 : 1
stoichiometry:c165 : 1

m89*m16910*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 15082713 IRAK-2a and IRAK-2b were found in overexpression studies to enhance NFkappaB activation. PMID: 17621314, 15082713 The overexpression of IRAK-2c and IRAK-2d, which lack the N-terminal DD, were shown in fibroblasts to have inhibitory effects on NF-kappaB activation following LPS stimulation. PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha.

Go back
1187.0, 1295.0
23.0, 23.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e83 MO000038724 e84 e85 MO000016882 e117

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c166 : 1
stoichiometry:c169 : 1
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c281 : 1
stoichiometry:c167 : 1

m90*m16910*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 15082713 IRAK-2a and IRAK-2b were found in overexpression studies to enhance NFkappaB activation. PMID: 17621314, 15082713 The overexpression of IRAK-2c and IRAK-2d, which lack the N-terminal DD, were shown in fibroblasts to have inhibitory effects on NF-kappaB activation following LPS stimulation. PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha.

Go back
1259.0, 915.0
23.0, 23.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c175 : 1
stoichiometry:c174 : 1

m66*m93*0.1

nodelay

--

true

0

false

PMID: 17621314, 10854325 Toll-interacting protein (Tollip) is a protein which interacts with the IL-1R accessory protein and is responsible for bringing IRAK to the receptor complex.

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571.0, 331.0
23.0, 23.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e88

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m3964*m95*0.1

nodelay

--

true

0

false

PMID: 17621314, 11751856 There are three known isoforms of Tollip, however, Tollip-1 has been shown to bind TLR-2 and TLR-4, and in overexpression studies leads to the subsequent inhibition of NF-kappaB activation.

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270.0, 292.0
25.0, 25.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e88 e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m95*m96*0.1

nodelay

--

true

0

false

PMID: 17621314, 11751856 There are three known isoforms of Tollip, however, Tollip-1 has been shown to bind TLR-2 and TLR-4, and in overexpression studies leads to the subsequent inhibition of NF-kappaB activation.

Go back
1241.0, 653.0
22.0, 22.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000019406

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c183 : 1
stoichiometry:c185 : 1

m40*m3973*0.1

nodelay

--

true

0

false

PMID: 17621314, 11751856 Tollip also interacts with IRAK-1 leading to a decrease in IRAK-1 autophosphorylation and NF-kappaB activation.

Go back
1093.0, 1137.0
27.0, 27.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e39 e91 e90 MO000017004 e116 e117 e80 e123 e124 e129 e132 e134 e175 e187

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c230 : 1
stoichiometry:c271 : 1
stoichiometry:c276 : 1
stoichiometry:c282 : 1
stoichiometry:c299 : 1
stoichiometry:c302 : 1
stoichiometry:c329 : 1
stoichiometry:c332 : 1
stoichiometry:c338 : 1
stoichiometry:c413 : 1
stoichiometry:c503 : 1
stoichiometry:c188 : 1

m16910*m187*0.1

nodelay

--

true

0

false

PMID: 17621314, 11751856 Tollip also interacts with IRAK-1 leading to a decrease in IRAK-1 autophosphorylation and NF-kappaB activation. PMID: 17621314, 11751856 There are three known isoforms of Tollip, however, Tollip-1 has been shown to bind TLR-2 and TLR-4, and in overexpression studies leads to the subsequent inhibition of NF-kappaB activation. PMID: 17621314, 15334086 A20, was originally associated with TNF mediated NF-kappaB activation, but has also been identified as a cysteine protease de-ubiquitylating protein able to prevent TLR signalling via TRAF-6. Ablation of TLR-mediated signalling is the result of the cleavage of a polyubiquitin chain in TRAF-6 that in turn inhibits NFkappaB translocation to the nucleus. PMID: 17621314 Investigators identified that SOCS-1 directly inhibits Mal-dependent p65 phosphorylation and subsequent NF-kappaB transactivation. PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha. PMID: 17621314, 15125834, 15173580 beta-arrestin-1 and beta-arrestin-2 have recently been identified as negative regulators of TLR-IL-1R-mediated signalling pathways augmenting NF-kappaB activation. PMID: 17621314, 16378096 The binding of beta-arrestins to the TRAF-N domain in TRAF-6 prevents autoubiquitination, thus preventing downstream activation of NF-kappaB and AP- 1 Wang et al. PMID: 17621314, 16670302 PI3K class I enzymes were shown to affect NF-kappaB activation and IL-12 production, where as the class III PI3Ks were shown to be involved in both NF-kappaB activation as well as the production of IL-6, IL-12 and TNF-alpha. PMID: 17621314, 16670302 In recent studies by Kuo et al., they demonstrated that the class I and class III PI3K enzymes have distinct negative regulatory roles in TLR signalling in response to CpG DNA/ODN. PMID: 17621314, 10385526, 11390377 LIND has been identified as an LPS-inducible A20-binding inhibitor of NFkappa-B and shares sequence homology to A20-binding inhibitor of NF-kappaB activation (ABIN)?1 and ABIN-2. PMID: 17621314, 17088249 Subsequent coexpression studies using MyD88, IRAK-1, TRAF-6 and downstream IKKbeta with ABIN-3 revealed that ABIN-3 inhibits MyD88, IRAK-1 and TRAF-6-mediated NF-kappaB activation, however has no effect on IKKbeta induced activation. PMID: 17621314 Further investigations by Wang et al. revealed that Fliih was able to inhibit TLR-4?MyD88-dependent activation of NF-kappaB. PMID: 17621314 Furthermore, overexpression studies in HEK-293 cells cotransfected with TLR-2, TLR-3, TLR-4 and TLR-9, stimulated with their appropriate ligands and increasing doses of TRAF-4, resulted in luciferase analysis showing a decrease in activation of both NF-kappaB and the IFN-beta promoter, but not in TNF-alpha receptor-mediated signalling.

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1422.0, 754.0
25.0, 25.0

p59

p59

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e39

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 17621314 With decreasing levels of IRAK-1 phosphorylation, it has been observed there is an increase in Tollip phosphorylation.

Go back
232.0, 408.0
22.0, 22.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m3965*m23*0.1

nodelay

--

true

0

false

PMID: 17621314 TRIF has been shown to be critical for signalling by lipopolysaccharide (LPS) via TLR-4 and for signalling by polyI:C via TLR-3, while TRAM was shown to be required for TLR-4 signalling only.

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1237.0, 701.0
29.0, 29.0

p60

p60

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e92

MO000019406 e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m99*0.1

nodelay

--

true

0

false

PMID: 17621314, 11751856 This is though to be a mechanism that allows the release of Tollip from the Tollip/IRAK-1 complex resulting in the termination of its negative regulatory actions.

Go back
1083.0, 1695.0
25.0, 25.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c200 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 1381359, 2118515 A20 is a zinc ring finger protein which is expressed in numerous cell types and rapidly increases in expression in response to LPS and TNF, implicating it as a possible regulator of inflammatory responses.

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1064.0, 1732.0
23.0, 23.0

p62

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e94

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c201 : 1

m101*0.1

nodelay

--

true

0

false

PMID: 17621314, 1381359, 2118515 A20 is a zinc ring finger protein which is expressed in numerous cell types and rapidly increases in expression in response to LPS and TNF, implicating it as a possible regulator of inflammatory responses.

Go back
1002.0, 830.0
25.0, 25.0

p63

p63

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e41 MO000016591 e118 e119 e171

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c204 : 1
stoichiometry:c289 : 1
stoichiometry:c290 : 1
stoichiometry:c457 : 1
stoichiometry:c203 : 1

m46*m178*0.1

nodelay

--

true

0

false

PMID: 17621314, 15334086 A20, was originally associated with TNF mediated NF-kappaB activation, but has also been identified as a cysteine protease de-ubiquitylating protein able to prevent TLR signalling via TRAF-6. Ablation of TLR-mediated signalling is the result of the cleavage of a polyubiquitin chain in TRAF-6 that in turn inhibits NFkappaB translocation to the nucleus. PMID: 17621314, 16378096 The binding of beta-arrestins to the TRAF-N domain in TRAF-6 prevents autoubiquitination, thus preventing downstream activation of NF-kappaB and AP- 1 Wang et al. PMID: 17621314, 11057907 Ubc13 E2 ubiquitin-conjugating enzyme is known to olyubiquitinate TRAF-2 and TRAF-6 through their attached K63 polyubiquitin chains.

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270.0, 322.0
25.0, 25.0

p64

p64

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e89 MO000061958

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c209 : 1

m96*m36851*0.1

nodelay

--

true

0

false

PMID: 17621314, 15107846 Triad3A when overexpressed results in substantial degradation of TLR-4 and TLR-9, which lead to a decrease in signal transduction, but did not effect TLR-2 or TLR-3 mediated signalling.

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268.0, 572.0
27.0, 27.0

p65

p65

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000042012 MO000061958

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c208 : 1
stoichiometry:c210 : 1

m19828*m36851*0.1

nodelay

--

true

0

false

PMID: 17621314, 15107846 Triad3A when overexpressed results in substantial degradation of TLR-4 and TLR-9, which lead to a decrease in signal transduction, but did not effect TLR-2 or TLR-3 mediated signalling.

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614.0, 542.0
27.0, 27.0

p66

p66

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000068831 MO000061958

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c213 : 1
stoichiometry:c212 : 1

m43675*m36851*0.1

nodelay

--

true

0

false

PMID: 17621314, 16968706 Recent studies have also suggested that Triad3A is able to target other TIR domain-containing adaptors including RIP-1, TRIF and Mal.

Go back
304.0, 736.0
29.0, 29.0

p67

p67

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e96 MO000061958

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c218 : 1

m103*m36851*0.1

nodelay

--

true

0

false

PMID: 17621314, 16968706 Recent studies have also suggested that Triad3A is able to target other TIR domain-containing adaptors including RIP-1, TRIF and Mal.

Go back
584.0, 592.0
27.0, 27.0

p68

p68

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000041125

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m18998*0.1

nodelay

--

true

0

false

PMID: 17621314, 16968706 Recent studies have also suggested that Triad3A is able to target other TIR domain-containing adaptors including RIP-1, TRIF and Mal.

Go back
747.0, 1765.0
23.0, 23.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c219 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 12433365, 12433373 LPS induces SOC-1 expression in macrophages and SOCS-1-/- mice are hypersensitive to LPS-induced endotoxic shock.

Go back
399.0, 351.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 MO000041125 e81

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c160 : 1
stoichiometry:c21 : 1

m24*m18998*0.1

nodelay

--

true

0

false

PMID: 17621314, 17048703, 16807108, 16698941 TRIF has been found to induce the expression of IFN-beta in response to TLR-4 and TLR-3 ligands. PMID: 17621314 To date, it is still unclear in regards to the exact mechanism of how SARM inhibits TRIF function, however, it can be hypothesized from finding by Bowie and colleagues, who demonstrated that SARM and TRIF weakly interact in resting cells and upon LPS stimulation, increase in stability possibly preventing the recruitment of downstream effector molecules to TRIF.

Go back
927.0, 467.0
25.0, 25.0

p70

p70

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e99

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c222 : 1

m106*0.1

nodelay

--

true

0

false

PMID: 17621314, 16415872 Recent investigations by Mansell et al. have shown the mechanism for SOCS-1 directly regulating TLR-2 and TLR-4-mediated signalling by argeting Mal for polyubiquitination and subsequent proteosomal degradation.

Go back
979.0, 627.0
26.0, 26.0

p71

p71

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e98

e67 MO000017004

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c229 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 17621314, 16415872 Recent investigations by Mansell et al. have shown the mechanism for SOCS-1 directly regulating TLR-2 and TLR-4-mediated signalling by argeting Mal for polyubiquitination and subsequent proteosomal degradation.

Go back
1031.0, 435.0
23.0, 23.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 MO000017004 e100

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c223 : 1
stoichiometry:c228 : 1
stoichiometry:c227 : 1

m43675*m1906*m107*0.1

nodelay

--

true

0

false

PMID: 17621314, 16415872 Activation of Brunton¡Çs tyrosine kinase is critical for mediating the Mal and SOCS-1 interaction (acting as an E3 ubiquitin ligase) resulting in Mal polyubiquitination and subsequent proteosomal degradation.

Go back
166.0, 822.0
25.0, 25.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000314 e102

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c233 : 1
stoichiometry:c232 : 1

m249*m109*0.1

nodelay

--

true

0

false

PMID: 17621314 The coupling of beta-arrestins to the GPCRs occurs following binding of a ligand to the appropriate receptor.

Go back
291.0, 871.0
23.0, 23.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e101 MO000017072

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c236 : 1

m108*m1964*0.1

nodelay

--

true

0

false

PMID: 17621314, 10995467, 10725339, 11861753 Beta-arrestins are adaptor molecules that are able to form complexes with G protein?coupled receptors (GPCRs), are involved in the desensitization and endocytosis of various cell surface receptors as well as being shown to bind molecules involved in the MAP signalling pathway including Erk-1/-2, JNK, p38 and members of the Src kinase family.

Go back
323.0, 791.0
23.0, 23.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000004670 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c237 : 1
stoichiometry:c242 : 1

m549*m110*0.1

nodelay

--

true

0

false

PMID: 17621314, 10995467, 10725339, 11861753 Beta-arrestins are adaptor molecules that are able to form complexes with G protein?coupled receptors (GPCRs), are involved in the desensitization and endocytosis of various cell surface receptors as well as being shown to bind molecules involved in the MAP signalling pathway including Erk-1/-2, JNK, p38 and members of the Src kinase family. PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
327.0, 863.0
23.0, 23.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000004676 e103

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c238 : 1
stoichiometry:c244 : 1

m554*m110*0.1

nodelay

--

true

0

false

PMID: 17621314, 10995467, 10725339, 11861753 Beta-arrestins are adaptor molecules that are able to form complexes with G protein?coupled receptors (GPCRs), are involved in the desensitization and endocytosis of various cell surface receptors as well as being shown to bind molecules involved in the MAP signalling pathway including Erk-1/-2, JNK, p38 and members of the Src kinase family. PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
319.0, 939.0
23.0, 23.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000023 e103

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c239 : 1
stoichiometry:c246 : 1

m21*m110*0.1

nodelay

--

true

0

false

PMID: 17621314, 10995467, 10725339, 11861753 Beta-arrestins are adaptor molecules that are able to form complexes with G protein?coupled receptors (GPCRs), are involved in the desensitization and endocytosis of various cell surface receptors as well as being shown to bind molecules involved in the MAP signalling pathway including Erk-1/-2, JNK, p38 and members of the Src kinase family. PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
318.0, 1006.0
25.0, 25.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000022 e103

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c240 : 1
stoichiometry:c248 : 1

m20*m110*0.1

nodelay

--

true

0

false

PMID: 17621314, 10995467, 10725339, 11861753 Beta-arrestins are adaptor molecules that are able to form complexes with G protein?coupled receptors (GPCRs), are involved in the desensitization and endocytosis of various cell surface receptors as well as being shown to bind molecules involved in the MAP signalling pathway including Erk-1/-2, JNK, p38 and members of the Src kinase family. PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
454.0, 822.0
25.0, 25.0

p79

p79

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e104

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m111*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
933.0, 362.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000041132

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m16*m19005*0.1

nodelay

--

true

0

false

PMID: 17621314 TRIF has been shown to be critical for signalling by lipopolysaccharide (LPS) via TLR-4 and for signalling by polyI:C via TLR-3, while TRAM was shown to be required for TLR-4 signalling only.

Go back
450.0, 910.0
25.0, 25.0

p80

p80

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e105

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1

m112*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
451.0, 979.0
23.0, 23.0

p81

p81

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e106

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c254 : 1

m113*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
450.0, 1058.0
25.0, 25.0

p82

p82

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e107

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
565.0, 821.0
27.0, 27.0

p83

p83

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e108

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c258 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
562.0, 906.0
25.0, 25.0

p84

p84

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e109

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c260 : 1

m116*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
562.0, 970.0
26.0, 26.0

p85

p85

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e110

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c262 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
566.0, 1038.0
27.0, 27.0

p86

p86

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e111

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c264 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 17621314 This results in the interaction of b-arrestins with the signalling complexes and the subsequent mediation of phosphorylation and ubiquitination of MAP kinase target molecules.

Go back
1270.0, 1126.0
25.0, 25.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017073 MO000038724

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c266 : 1
stoichiometry:c267 : 1

m1965*m16910*0.1

nodelay

--

true

0

false

PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha.

Go back
962.0, 1262.0
25.0, 25.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017074 MO000038724

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c268 : 1
stoichiometry:c270 : 1
stoichiometry:c269 : 1

m1966*m16910*0.1

nodelay

--

true

0

false

PMID: 17621314, 15125834, 15173580 For example, beta-arrestin-1 and beta-arrestin-2 have been shown to directly interact with IkappaB-alpha, preventing its phosphorylation and subsequent degradation, as well as blocking TNF-induced phosphorylation and degradation of IkappaB-alpha.

Go back
1087.0, 1007.0
25.0, 25.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000017073

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c285 : 1
stoichiometry:c287 : 1

m183*m1965*0.1

nodelay

--

true

0

false

PMID: 17621314, 16378096 Wang et al., demonstrated using overexpression studies in HEK-293 cells, that beta-arrestin-1 and beta-arrestin-2 co-immunoprecipitated with TRAF-6, showing direct interactions.

Go back
886.0, 415.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e22 e81

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c161 : 1
stoichiometry:c27 : 1

m18998*m26*0.1

nodelay

--

true

0

false

PMID: 17621314, 17048703, 16807108, 16698941 TRIF has been found to induce the expression of IFN-beta in response to TLR-4 and TLR-3 ligands. PMID: 17621314 To date, it is still unclear in regards to the exact mechanism of how SARM inhibits TRIF function, however, it can be hypothesized from finding by Bowie and colleagues, who demonstrated that SARM and TRIF weakly interact in resting cells and upon LPS stimulation, increase in stability possibly preventing the recruitment of downstream effector molecules to TRIF.

Go back
1023.0, 1087.0
25.0, 25.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000017074

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c286 : 1
stoichiometry:c288 : 1

m183*m1966*0.1

nodelay

--

true

0

false

PMID: 17621314, 16378096 Wang et al., demonstrated using overexpression studies in HEK-293 cells, that beta-arrestin-1 and beta-arrestin-2 co-immunoprecipitated with TRAF-6, showing direct interactions.

Go back
805.0, 1365.0
27.0, 27.0

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e121 e156

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c291 : 1
stoichiometry:c401 : 1
stoichiometry:c292 : 1

m128*m163*0.1

nodelay

--

true

0

false

PMID: 17621314, 16378096 The binding of beta-arrestins to the TRAF-N domain in TRAF-6 prevents autoubiquitination, thus preventing downstream activation of NF-kappaB and AP- 1 Wang et al.

Go back
1178.0, 1562.0
27.0, 27.0

p92

p92

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e122 MO000016882 MO000017074 MO000017073

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c294 : 1
stoichiometry:c296 : 1
stoichiometry:c297 : 1
stoichiometry:c298 : 1
stoichiometry:c295 : 1

m129*m155666*0.1

nodelay

--

true

0

false

PMID: 17621314, 17418896 Further studies also revealed that both bera-arrestin-1 and beta-arrestin-2 depletion using siRNA transfection resulted in the marked decrease of IL-8 production following LPS treatment.

Go back
586.0, 1654.0
27.0, 27.0

p93

p93

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e123 e124

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c303 : 1
stoichiometry:c306 : 1
stoichiometry:c300 : 1

m93589*0.1

nodelay

--

true

0

false

PMID: 17621314, 16670302 PI3K class I enzymes were shown to affect NF-kappaB activation and IL-12 production, where as the class III PI3Ks were shown to be involved in both NF-kappaB activation as well as the production of IL-6, IL-12 and TNF-alpha. PMID: 17621314, 16670302 PI3K class I enzymes were shown to affect NF-kappaB activation and IL-12 production, where as the class III PI3Ks were shown to be involved in both NF-kappaB activation as well as the production of IL-6, IL-12 and TNF-alpha. PMID: 17621314, 16670302 In recent studies by Kuo et al., they demonstrated that the class I and class III PI3K enzymes have distinct negative regulatory roles in TLR signalling in response to CpG DNA/ODN.

Go back
1112.0, 434.0
21.0, 21.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017443 MO000016573

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c307 : 1
stoichiometry:c308 : 1
stoichiometry:c309 : 1

m2269*m1572*0.1

nodelay

--

true

0

false

PMID: 17621314, 15623538 TGF-beta1 inhibits TLR-4 expression by suppressing LPS-mediated responses and is also able to induce MyD88 degradation through interactions via its DD.

Go back
1062.0, 544.0
25.0, 25.0

p95

p95

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e125

MO000017443 e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1

m132*0.1

nodelay

--

true

0

false

PMID: 17621314, 15623538 TGF-beta1 inhibits TLR-4 expression by suppressing LPS-mediated responses and is also able to induce MyD88 degradation through interactions via its DD.

Go back
675.0, 1823.0
25.0, 25.0

p96

p96

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e126 MO000017247 e21

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c317 : 1
stoichiometry:c319 : 1
stoichiometry:c321 : 1
stoichiometry:c314 : 1

m133*m25*0.1

nodelay

--

true

0

false

PMID: 17621314, 15330257 IL-10 is also shown to inhibit the production of pro-inflammatory cytokines through LPS, and in human DCs is known to downregulate IL-12 production through TLR-3- and TLR-4-mediated signalling.

Go back
682.0, 1858.0
27.0, 27.0

p97

p97

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e126 e15 MO000017247

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c316 : 1
stoichiometry:c318 : 1
stoichiometry:c320 : 1
stoichiometry:c315 : 1

m133*m17*0.1

nodelay

--

true

0

false

PMID: 17621314, 15330257 IL-10 is also shown to inhibit the production of pro-inflammatory cytokines through LPS, and in human DCs is known to downregulate IL-12 production through TLR-3- and TLR-4-mediated signalling.

Go back
886.0, 1744.0
25.0, 25.0

p98

p98

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000036861

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c324 : 1
stoichiometry:c322 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17621314, 12161427 Previous studies have shown that ATF-3 is able to protect endothelial cells against TNF-induced apoptosis by decreasing p53 transcription.

Go back
80.0, 1554.0
29.0, 29.0

p99

p99

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

MO000000289 MO000036861

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c323 : 1
stoichiometry:c325 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 17621314, 12161427 Previous studies have shown that ATF-3 is able to protect endothelial cells against TNF-induced apoptosis by decreasing p53 transcription.

Go back
1355.0, 418.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 225.83509185099385

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 1392.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.7920642163135, 1348.8121079572823

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1050.9249690339477, 1419.0930991770963

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 1427.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1156.9536192064468, 1121.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1153.9999178197581, 1223.0256404988445

c105

c105

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
781.0, 323.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.0, 359.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.0, 332.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.0, 206.58118570263417

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.0, 229.76582449857102

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.4898759102475, 200.677767701542

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.097553721736, 199.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
875.0, 187.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.0, 170.53219863522304

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1380.0, 1389.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1464.0, 1428.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1382.0, 1428.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1107.935996928472, 1382.7126908018631

c117

c117

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
925.0, 1463.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.0, 1464.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.3662937882875, 223.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.839493298193, 1467.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 1489.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
891.0, 1527.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.0, 1567.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.3612370850286, 1385.1324413127782

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.9975603804354, 1480.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.1129744337713, 1480.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 1529.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 1612.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.9844206278631, 1571.4990262892416

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1059.0, 399.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.9997001724007, 1527.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.9981373931013, 1567.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.8207152494824, 1444.488102949512

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.3791098580297, 1544.7547378070226

c133

c133

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
594.7119342509336, 1588.615146071804

c134

c134

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
611.7288423435223, 1628.6070908154973

c135

c135

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
780.0, 1469.368118276229

c136

c136

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1093.0, 2064.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.0, 2015.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.0, 2015.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.0, 336.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 1230.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.9792745494692, 1286.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1136.0, 1295.9980600510892

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1193.0, 1488.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1185.0, 1495.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1137.0, 1508.9789713630944

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.0, 290.0

c146

c146

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1341.3526867907, 208.6462320697756

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1341.0, 201.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
986.0, 187.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1109.0, 330.9382230137093

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.0, 1236.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1118.9406911095632, 1329.97232952362

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.9999662000478, 1336.1644224185543

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.8599434057004, 1728.1159660434203

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.9995919096077, 1743.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
135.17560211570867, 130.7958089041487

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
627.0, 441.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0, 483.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.0, 471.08319999596534

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.1882212958068, 198.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
261.2636750760036, 427.352465419694

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.24226923162985, 373.34258195793154

c160

c160

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
642.0, 432.28816739410206

c161

c161

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1214.8511412388802, 1258.5360928510852

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1217.9336200532975, 1309.028432229131

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1054.0, 1226.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1117.540845115145, 1264.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.0, 1231.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1118.8676255087125, 1309.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1207.522370500378, 1270.104456000465

c168

c168

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1213.5294117647059, 1314.8823529411766

c169

c169

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
116.0, 419.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1203.9250352487709, 1270.5063142031183

c170

c170

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1211.6464865483474, 1320.9993514214605

c171

c171

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
984.0, 118.54163360056106

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.0, 102.57906055983074

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1282.0, 935.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1271.296093284079, 888.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1298.0, 976.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.1554175279994, 319.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0, 360.2179589656599

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 321.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.0, 420.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.642722585643, 311.3640624947116

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.0, 305.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
234.50986776965388, 270.64990554975276

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.0, 664.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.9988891203168, 663.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1263.0, 671.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1355.0, 734.0

c186

c186

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1053.0, 1169.7868443531486

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.7192970072542, 1164.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
962.0, 998.0

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
373.0, 380.3409919128368

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1108.314867854611, 720.0

c190

c190

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
583.0, 313.0

c191

c191

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
215.0, 273.0

c192

c192

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1355.0, 724.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1359.0, 767.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1272.8485155621995, 729.1349527922713

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1204.340991912837, 679.8776860867976

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1266.0, 677.1861042666906

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1035.0, 843.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.9995400349283, 1744.0857859521172

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1441.2221365379228, 403.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.6626102817692, 368.2987830845308

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.0, 1708.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1052.9987028429207, 1723.2929730966948

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.0, 86.50258276026557

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.9650738084744, 844.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.2798323346794, 853.2896942713801

c204

c204

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
302.9970797589828, 586.2161372907833

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.0, 310.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.0, 355.0

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
282.1126648820378, 501.0

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
155.17635842090328, 334.81260740797086

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.0, 374.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 599.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.4802023498434, 405.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.5414799426919, 569.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.0, 490.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
302.0, 697.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 501.0

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.3067151496019, 441.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.8656536710209, 619.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.0, 765.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.0, 1777.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.405400982828, 323.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
111.21821714383731, 115.26194032329624

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1043.0, 416.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 492.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 447.0400003962742

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 548.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.9994602216135, 653.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
959.9949028347804, 479.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.8383001217738, 454.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.0, 466.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.7857263497755, 608.8391479566399

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
946.2855322440993, 394.9949028347804

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 616.0

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
199.0, 835.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
191.0, 844.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
99.0, 835.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.0, 883.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 836.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.214045989756, 893.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.0, 820.4837406229888

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.0, 886.129760386924

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.0, 938.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.0, 310.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.0, 948.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.0, 803.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 810.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.0, 875.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.0, 884.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.0, 951.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.0, 958.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 1019.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 1029.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 837.8644734461474

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 427.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.0, 835.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.0, 923.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 920.4697761756117

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 991.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 986.0237707010416

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.0, 1071.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 1066.0237707010415

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.0, 835.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 829.796029752168

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 919.0

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.4894174093658, 302.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.0, 910.2397421507617

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 983.0

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 974.1940215386404

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
533.0, 1055.4310835055999

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0, 1051.1666305094548

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1242.0, 1123.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 1145.6240935117632

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1224.0, 1139.0

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 1278.1313708498985

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 1275.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.0, 322.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.2140459897561, 1235.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1123.9733829441327, 1141.0

c271

c271

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1175.5956920443866, 1158.0

c272

c272

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1150.4474885996535, 1157.0

c273

c273

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1157.4359163172355, 1158.0

c274

c274

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1196.2849881999516, 1158.0

c275

c275

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1049.0, 1167.5158617085117

c276

c276

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1051.0, 1281.0

c277

c277

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1051.0, 1231.864956306883

c278

c278

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1051.0, 1257.484945906863

c279

c279

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
679.0, 168.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 1275.0

c280

c280

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1051.0, 1278.0

c281

c281

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1123.9999848275281, 245.0

c282

c282

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1110.811726938049, 852.0

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.2217817366136, 852.0

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1118.371570530798, 1033.8376739215316

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
930.0, 1118.7911752716327

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 1020.0

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.104456000465, 1075.3730830011045

c288

c288

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.47973355535, 858.9711277637305

c289

c289

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
648.0, 228.55988858752207

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.0219776902318, 858.9999396221858

c290

c290

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
837.6568542494924, 1397.6568542494924

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 1381.0

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 640.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 1576.0999921884154

c294

c294

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1205.0, 1583.0

c295

c295

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.0, 73.13251544113382

c296

c296

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.0, 1294.0

c297

c297

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1208.9651046114066, 1127.0

c298

c298

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
862.0, 1153.5151543239092

c299

c299

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1364.0, 452.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 221.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 1668.0

c300

c300

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.9930645847388, 1665.0

c301

c301

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.0, 1151.1066523765396

c302

c302

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
600.0587720407789, 1184.7119322724898

c303

c303

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
586.5177164138728, 1375.0

c304

c304

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
615.002402050327, 1368.8220774259448

c305

c305

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
596.2518160410447, 1376.0

c306

c306

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1087.0, 461.1143318680631

c307

c307

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1123.2756982067183, 462.9952479948287

c308

c308

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.0, 445.0

c309

c309

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 324.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.2522975990207, 456.0

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.0, 522.0

c311

c311

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.6905065822062, 557.0

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.999999999598, 456.50388241336395

c313

c313

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
631.9256926368353, 1838.0

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.7451752928928, 1855.0030625757481

c315

c315

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.6810880568495, 1845.0

c316

c316

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
707.9953552878064, 1836.272568930266

c317

c317

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
54.95225507638372, 64.5575009479087

c318

c318

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.0, 1846.1094514471126

c319

c319

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
739.0, 399.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 1874.7261899178245

c320

c320

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
82.543223714536, 424.0

c321

c321

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
899.0, 1723.0

c322

c322

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.99991142015634, 1569.0376466419773

c323

c323

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
899.0, 1773.0

c324

c324

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
95.00450118743652, 1586.999997467413

c325

c325

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1066.0, 896.0

c326

c326

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.0, 914.0

c327

c327

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1058.0, 905.0

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 959.0

c329

c329

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
718.0, 327.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.0, 1628.0

c330

c330

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
986.0, 188.0

c331

c331

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
977.0, 1155.9701425001454

c332

c332

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
977.0, 1191.0

c333

c333

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
931.0, 501.0

c334

c334

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.0, 501.0

c335

c335

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
911.0, 513.0

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.9750218923913, 502.6316849023676

c337

c337

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
911.0, 575.0

c338

c338

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1128.0, 323.0

c339

c339

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1359.0, 336.9522635832987

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 314.0

c340

c340

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1126.0, 378.9209918144369

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.0, 372.58110810409005

c342

c342

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1040.0, 759.0

c343

c343

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.8458558686448, 783.1393547112735

c344

c344

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1058.2121844597461, 777.0

c345

c345

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 801.0

c346

c346

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1051.0, 807.0

c347

c347

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
597.00103304018, 814.0

c348

c348

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
980.0, 796.0

c349

c349

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1442.2050608063405, 348.99737144727584

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.0, 796.0

c350

c350

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.1234844292652, 200.0

c351

c351

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
401.6975352836395, 235.5314874622162

c352

c352

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 168.0

c353

c353

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 228.0

c354

c354

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.0, 183.0

c355

c355

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 233.0

c356

c356

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.6678849327202, 227.2811270588379

c357

c357

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.9997356202184, 1223.0

c358

c358

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 1231.0

c359

c359

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1359.0, 328.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
722.0, 319.0

c360

c360

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1037.0, 1583.9402850002907

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.0, 48.60824511044177

c362

c362

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.0, 1700.3197443067909

c363

c363

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
43.532115753118546, 103.50006446488885

c364

c364

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
700.0, 1246.0

c365

c365

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.99969536633, 1408.069814367565

c366

c366

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
714.0, 1224.0

c367

c367

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1240.0, 1488.0

c368

c368

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1279.272706637531, 1500.0

c369

c369

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1351.0, 345.0

c37

c37

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
714.0, 1230.0

c370

c370

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
720.0, 35.66134989504474

c371

c371

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
911.8062143832788, 842.0

c372

c372

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 926.8390472797308

c373

c373

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 920.0

c374

c374

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.0, 1094.0

c375

c375

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0, 1147.2757958046864

c376

c376

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.0, 1128.0

c377

c377

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1224.0, 1504.0

c378

c378

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1245.0, 1692.0

c379

c379

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.9669713057376, 213.51297042746606

c38

c38

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1236.0, 1705.0

c380

c380

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1212.9990241521741, 1447.7462185896748

c381

c381

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1215.0, 1440.0

c382

c382

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.0, 844.0

c383

c383

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.8497638868437, 1542.0

c384

c384

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1050.9985763857883, 1540.150916535581

c385

c385

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1050.893154684862, 1507.3031151602368

c386

c386

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.924156955824, 1506.0

c387

c387

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1223.89232114996, 1431.9218655355169

c388

c388

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
792.0, 856.0

c389

c389

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.0, 188.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.0, 888.0

c390

c390

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 900.0

c391

c391

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 898.0

c392

c392

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.5455335748853, 956.5995641337032

c393

c393

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 956.0

c394

c394

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 815.0

c395

c395

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.6568542494924, 787.0

c396

c396

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 856.0

c397

c397

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.6115561484353, 984.0

c398

c398

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.8776860867976, 857.0

c399

c399

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1269.0189691164192, 460.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 175.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.9189359186286, 863.974377482305

c400

c400

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
820.4540039845019, 890.0

c401

c401

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
792.0, 1003.0

c402

c402

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 1032.0

c403

c403

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 751.0

c404

c404

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
684.0, 761.0

c405

c405

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
808.0, 817.6039472493969

c406

c406

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.0, 816.0

c407

c407

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.0, 319.0

c408

c408

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
700.0, 803.9081971082276

c409

c409

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
529.0301818392622, 191.25708160345943

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.0, 716.0

c410

c410

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.4204706649821, 869.0

c411

c411

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 932.0

c412

c412

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.0, 1125.0

c413

c413

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 660.0

c414

c414

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.5777087639997, 652.0

c415

c415

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0, 728.0

c416

c416

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
699.0, 640.0

c417

c417

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.4698886744255, 649.0

c418

c418

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.0, 651.0

c419

c419

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.06215041882723, 195.22018508287903

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 692.0

c420

c420

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.0, 434.0

c421

c421

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.6658035338168, 314.0

c422

c422

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
755.0, 640.0

c423

c423

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
770.7028985140694, 655.0

c424

c424

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
624.9991953329289, 1608.0

c425

c425

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
932.0, 1608.0

c426

c426

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 708.0

c427

c427

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.0, 650.0

c428

c428

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 692.0

c429

c429

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.21676050979244, 198.79845061782865

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 692.0

c430

c430

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0110163756475, 707.0

c431

c431

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 752.0

c432

c432

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0, 752.0

c433

c433

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.5832878040848, 764.0

c434

c434

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.8441746598661, 653.3666295529669

c435

c435

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 707.0

c436

c436

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
324.0, 1120.0

c437

c437

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.0, 1129.0

c438

c438

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.19577838716464, 631.8989644514386

c439

c439

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 192.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 1188.0

c440

c440

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 1199.0

c441

c441

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 1258.0

c442

c442

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 1457.0

c443

c443

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.9973904104957, 632.2043199014097

c444

c444

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 1508.0

c445

c445

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 1363.9550543455823

c446

c446

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 1120.0

c447

c447

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 1120.0

c448

c448

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.0693241678343, 604.0

c449

c449

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1357.0, 500.1142740542628

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 1137.0

c450

c450

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 1188.0

c451

c451

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 623.9720297893892

c452

c452

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.0, 1241.0

c453

c453

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 1278.0

c454

c454

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.0, 1177.4144243370379

c455

c455

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
407.0, 1198.0

c456

c456

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1028.6588684319624, 646.0

c457

c457

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
803.0, 757.5777087639997

c458

c458

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.913627698831, 743.1723892887157

c459

c459

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1360.5433724859686, 513.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.0, 605.0

c460

c460

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.0, 648.0

c461

c461

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 636.0

c462

c462

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 1084.0

c463

c463

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 1124.0

c464

c464

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.237089400934, 998.0

c465

c465

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 1072.0

c466

c466

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.2625860380489, 1082.0

c467

c467

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.119467585175, 595.6606622172982

c468

c468

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
894.7021673083605, 646.0

c469

c469

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1184.0, 589.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.3456200196791, 767.2668305803784

c470

c470

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 1077.0

c471

c471

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 1090.2399915200253

c472

c472

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.9981994274514, 1104.1697230647735

c473

c473

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.5858940327249, 646.0

c474

c474

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1208.0, 71.0

c475

c475

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1208.0, 235.0

c476

c476

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.1159660434203, 227.0

c477

c477

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.1080982383762, 107.99926963983962

c478

c478

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
987.0510278538685, 100.58674100654063

c479

c479

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1272.0, 607.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 1909.0

c480

c480

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.5633258109788, 1851.0

c481

c481

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.9999992993223, 263.7181168617831

c482

c482

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1288.0, 1852.0

c483

c483

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1261.0, 1832.0

c484

c484

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1193.0, 223.50509577715002

c485

c485

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1096.0, 1440.0

c486

c486

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1184.0, 1781.0

c487

c487

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1199.0570138197743, 1787.198920166175

c488

c488

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1184.0, 1866.0

c489

c489

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1264.0, 615.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1122.0, 1908.0

c490

c490

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.9945186701341, 1846.296093284079

c491

c491

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
943.5458827133112, 1854.6570009553914

c492

c492

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
452.0, 19.58371209536881

c493

c493

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
296.0, 1436.0

c494

c494

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 1453.2570816034595

c495

c495

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.0, 1449.0

c496

c496

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 1535.0

c497

c497

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
287.0, 1498.0

c498

c498

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 1448.0

c499

c499

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1262.0, 501.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.0, 610.40026667774

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0654147323803, 840.0

c500

c500

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
32.01174675322568, 379.6300686689119

c501

c501

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.91046933007675, 587.0

c502

c502

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 1151.0519222505075

c503

c503

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
732.0, 1505.0

c504

c504

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.0, 1593.1959497450325

c505

c505

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1165.0, 552.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.0437687993774, 509.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1263.0, 552.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1352.0, 686.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1355.0, 835.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1267.3551186468871, 562.0

c56

c56

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1295.9975603804353, 791.2469504755443

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1250.9699247055655, 773.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1285.0, 637.5285977302406

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1141.0, 501.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1170.2790621242675, 785.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1099.9930645847387, 841.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1172.0, 840.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1198.0, 725.0

c63

c63

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1059.0, 361.685825578392

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1249.885143449429, 299.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1279.0, 299.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1141.0, 369.51838007815996

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1239.0, 317.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.0, 301.89932627056425

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
986.0, 190.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.0097272694131, 2021.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.0, 2072.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 2006.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.0, 1766.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
995.0, 1766.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.0, 1820.9999972967382

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.0, 1808.999989951243

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
966.9999467971021, 130.50212588558418

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
986.0, 146.50004859096737

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1074.0, 1672.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.0, 209.29878308453075

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 162.50459469559564

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1382.0, 900.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1429.0, 890.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1357.0, 927.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1290.0, 927.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1290.0, 987.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1122.3441554323335, 518.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1238.0, 1023.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1230.0, 1028.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1168.0, 1023.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1050.0, 216.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1106.62867960075, 619.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1275.0, 1067.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1201.0, 852.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1267.0, 1074.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1346.0, 1124.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1341.0, 1176.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1351.9202495140944, 1184.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.0, 1223.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1102.295369140932, 1235.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1091.0, 1347.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back