1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17635639.csml convertedTime:2009.07.01.11:06

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Pellino proteins: novel players in TLR and IL-1R signalling.
Authors Schauvliege R, Janssens S, Beyaert R.
Affiliation Unit of Molecular Signal Transduction in Inflammation, Department for MolecularBiomedical Research, VIB, Ghent, Belgium.
Abstract Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R)family play important roles in immunity and inflammation. They initiate commonintracellular signalling cascades leading to the activation of nuclear factor-?B(NF-?B) and other transcription factors that stimulate the expression of avariety of genes that shape an appropriate immune response. TLR/IL-1R signallinginvolves multiple proteinprotein interactions, but the mechanisms that regulatethese interactions are still largely unclear. In this context, Pellino proteinshave been suggested to function as evolutionary conserved scaffold proteins inTLR/IL-1R signalling. However, recently Pellino proteins were also proposed tofunction as novel ubiquitin ligases for IL-1R associated kinase 1 (IRAK-1). Herewe review our current knowledge on the expression, biological role and mechanismof action of Pellino proteins in TLR/IL-1R-induced signalling.
PMID 17635639
Model Abstract

Entity

MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000038:Elk-1{active} MO000000049:c-Jun MO000000203:NIK MO000000212:TRAF6 MO000000214:IL-1 MO000000248:IKK{active} MO000016573:MyD88 MO000016574:TAK1 MO000016882:LPS MO000017189:CREB MO000017765:Smad6 MO000018132:CD14 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019406:Tollip MO000019479:protein remnants MO000022131:MD-2 MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041419:Pellino1 MO000041420:Pellino MO000041425:Pellino1:IRAK-4 MO000041433:Pellino2 MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000044192:Bcl-10 MO000061452:TIFA e1: e10: e11:LPS:TLR4:MD2 e12:flagellin:TLR5 e13:ssRNA:TLR7 e14:ssRNA e15:ssRNA:TLR8 e16:CpG DNA e17:CpG DNA:TLR9 e18:LPS:CD14 e19:TLR4:MD2 e2: e20:LPS:TLR4:MD2:TIRAP e21:LPS:TLR4:MD2:TIRAP:MYD88 e22:lipoproteins:TLR2:TIRAP e23:lipoproteins:TLR2:TIRAP:MYD88 e24:flagellin:TLR5:MYD88 e25:ssDNA:TLR7:MYD88 e26:ssRNA:TLR8:MYD88 e27:CpG DNA:TLR9:MYD88 e28:LPS:TLR4:MD2:TRAM e29:LPS:TLR4:MD2:TRAM:TRIF e3: e30:IRAK1 e31:LPS:TLR4:MD2:TIRAP:MYD88:IRAK1:IRAK4 e32:LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4 e33:LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4 e34:LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4:Tollip{p} e35:LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4:TRAF6:TIFA e36:Tollip{p} e37:LPS:TLR4:MD2:TIRAP:MYD88:IRAK4 e38:IRAK1{p}:TRAF6:TIFA e39:TAK1:TAB1:TAB2 e4: e40:IRAK1{p}:TRAF6:TIFA:TAK1:TAB1:TAB2 e41:IRAK1{p}:TRAF6:TIFA:TAK1{p}:TAB1:TAB2{p} e42:TRAF6:TIFA:TAK1{p}:TAB1:TAB2{p} e43:IRAK1{p} e44:IRAK1{p} e45:(TRAF6)n:TIFA:TAK1{p}:TAB1:TAB2{p} e46:(TRAF6)n{ub}:TIFA:TAK1{p}:TAB1:TAB2{p} e47:p38{active} e48:JNK{active} e49:IKK e5:lipoproteins e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:lipoproteins:TLR2 e60: e61: e62: e63:TFs{p} e64:TFs e65:NF-kappaB:I-kappaB e66:NF-kappaB:I-kappaB{p} e67:NF-kappaB:IkappaB{p}{ub} e68:NF-kappaB{active} e69:pellino3 e7: e70:IRAK1{p}:TRAF6:TIFA:TAK1:TAB1:TAB2:pellino e71:IRAK1{p}:TRAF6:TIFA:TAK1:TAB1:TAB2:pellino{p} e72:TRAF6:TIFA:TAK1{p}:TAB1:TAB2{p}:pellino e73:IRAK1{p}{ub}:TRAF6:TIFA:TAK1:TAB1:TAB2:pellino{p} e74:pellino3:NIK e75:pellino1:smad6 e76:pellino1:IRAK1:TRAF6 e77:TGF-beta e78:pellino1:MYD88 e79:pellino2:Bcl10 e8: e80:ERK{active} e81:c-Jun{active} e82:Elk-1 e83:CREB{active} e84:CHOP e85:CHOP{active} e86:genes e87:pellino3:IRAK1 e88:pellino2:IRAK1 e89:Pellino2:IRAK4 e9: e90:pellino2:TRAF6 e91:pellino1:TRAF6 e92:Pellino3:TRAF6 e93:pellino1:TAK1 e94:TAK1:pellino2 e95:TAK1:pellino3

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p79 p8 p80 p81 p82 p9
Model Detail
762.0, 1136.0
30.0, 30.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1219.0, 1283.0
34.0, 34.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p51

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1387.0, 1299.0
34.0, 34.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p52

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
640.0, 1568.0
32.0, 32.0

Elk-1{active}

--

MO000000038

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57 p58 p59

p68

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000000038

--

Go back
506.0, 1338.0
36.0, 36.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p55 p56

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
982.0, 1094.0
32.0, 32.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
1556.0, 1332.0
32.0, 32.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p48 p75 p76 p77

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
226.0, 766.0
28.0, 28.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1357.0, 1577.0
38.0, 38.0

IKK{active}

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p39

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1557.0, 685.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p13 p17 p14 p15 p16 p49

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
556.0, 1040.0
32.0, 32.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p79 p80 p81

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1850.0, 298.0
36.0, 36.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
552.0, 1756.0
40.0, 40.0

CREB

--

MO000017189

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60 p61 p62

true true true true

csml-variable:Double

m2057

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
1194.0, 1078.0
44.0, 44.0

Smad6

--

MO000017765

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m2522

10

false

infinite

0

unit false false false
TRANSPATHMO000017765

--

Go back
1597.0, 325.0
38.0, 38.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p3

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
1632.0, 427.0
36.0, 36.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1218.0, 330.0
44.0, 44.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
1090.0, 322.0
36.0, 36.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
750.0, 331.0
46.0, 46.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1553.0, 1153.0
38.0, 38.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
1563.0, 1935.0
34.0, 34.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p41

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1695.0, 394.0
38.0, 38.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
755.0, 158.0
42.0, 42.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
1045.0, 164.0
38.0, 38.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1551.0, 586.0
30.0, 30.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p12

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1560.0, 936.0
32.0, 32.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p73 p74

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1564.0, 851.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1563.0, 762.0
38.0, 38.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1019.0, 843.0
34.0, 34.0

Pellino1

--

MO000041419

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p48 p49 p72 p73 p76 p79

true true true true

csml-variable:Double

m19287

10

false

infinite

0

unit false false false
TRANSPATHMO000041419

--

Go back
1337.0, 1089.0
30.0, 30.0

Pellino

--

MO000041420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43 p45

true true true true

csml-variable:Double

m19288

10

false

infinite

0

unit false false false
TRANSPATHMO000041420

--

Go back
1361.0, 745.0
30.0, 30.0

Pellino1:IRAK-4

--

MO000041425

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m19293

10

false

infinite

0

unit false false false
TRANSPATHMO000041425

--

Go back
847.0, 635.0
33.0, 33.0

Pellino2

--

MO000041433

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p71 p74 p75 p80

true true true true

csml-variable:Double

m19301

10

false

infinite

0

unit false false false
TRANSPATHMO000041433

--

Go back
1014.0, 318.0
44.0, 44.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
490.0, 333.0
44.0, 44.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
371.0, 394.0
42.0, 42.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
616.0, 335.0
40.0, 40.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
970.0, 534.0
36.0, 36.0

Bcl-10

--

MO000044192

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m21910

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044192

--

Go back
1483.0, 1299.0
26.0, 26.0

TIFA

--

MO000061452

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m36350

10

false

infinite

0

unit false false false
TRANSPATHMO000061452

--

Go back
345.97738307104873, 301.2424139112821
1364.6555558678776, 1981.47986712016

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
338.1257443339916, 341.5284161669259
1322.769127304459, 1860.764219849182

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1639.5, 544.6141197105898
20.866038149528613, 40.38588028941022

LPS:TLR4:MD2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p18 p10

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
674.5, 332.5904406928305
27.07827230870423, 52.40955930716948

flagellin:TLR5

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p14

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
570.5, 324.01183950887963
27.89388292041219, 53.98816049112037

ssRNA:TLR7

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p15

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
570.0, 169.5780530585398
52.10699408024556, 26.921946941460206

ssRNA

--

e14

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p6 p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
438.5, 324.3144047358036
27.737557553168166, 53.68559526419645

ssRNA:TLR8

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p16

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
174.0, 296.5
60.0, 21.0

CpG DNA

--

e16

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
374.5, 452.5904406928305
27.07827230870423, 52.40955930716948

CpG DNA:TLR9

--

e17

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

p17

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1631.5, 375.85288313966237
25.39267704450778, 49.14711686033764

LPS:CD14

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1633.5, 480.2567905349109
33.27362106315613, 40.74320946508916

TLR4:MD2

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
345.97738307104873, 301.2424139112821
1364.6555558678776, 1981.47986712016

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1632.5, 628.7159111763629
34.603596990273445, 48.284088823637376

LPS:TLR4:MD2:TIRAP

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1639.0, 723.264705882353
30.441176470588236, 50.735294117647065

LPS:TLR4:MD2:TIRAP:MYD88

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p20

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1289.5, 332.1394751330521
28.56670948797944, 39.86052486694807

lipoproteins:TLR2:TIRAP

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1358.0, 333.8529411764706
27.08823529411765, 45.14705882352941

lipoproteins:TLR2:TIRAP:MYD88

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
824.5, 329.8030831345202
30.957790420260604, 43.196916865479906

flagellin:TLR5:MYD88

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
877.5, 330.23453844742164
29.931914112681227, 41.76546155257846

ssDNA:TLR7:MYD88

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
385.5, 335.5248669480641
28.290512020554228, 39.47513305193614

ssRNA:TLR8:MYD88

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
376.5, 556.6909524683429
31.75481739768765, 44.309047531657185

CpG DNA:TLR9:MYD88

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1638.5, 795.604881629657
31.099834832079285, 43.3951183703432

LPS:TLR4:MD2:TRAM

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1657.0, 871.7352941176471
29.558823529411768, 49.26470588235294

LPS:TLR4:MD2:TRAM:TRIF

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
373.2704941884065, 328.5355250286397
1310.0693336331642, 1926.8936448854465

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1555.0, 884.2999999999998
41.59999999999999, 31.2

IRAK1

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20 p48 p70 p71 p72

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1635.0, 982.2058823529411
25.676470588235293, 42.79411764705882

LPS:TLR4:MD2:TIRAP:MYD88:IRAK1:IRAK4

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1638.0, 1049.2647058823527
27.44117647058823, 45.735294117647065

LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1643.0, 1106.176470588235
26.294117647058822, 43.82352941176471

LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22 p24

p23 p25

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1641.0, 1195.441176470588
29.735294117647058, 49.55882352941177

LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4:Tollip{p}

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1638.0, 1356.6470588235293
28.411764705882355, 47.35294117647059

LPS:TLR4:MD2:TIRAP:MYD88:IRAK1{p}:IRAK4:TRAF6:TIFA

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1554.0, 1261.7317073170732
36.58536585365854, 29.26829268292683

Tollip{p}

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1641.5, 1431.0713892457334
29.332171040557906, 40.92861075426684

LPS:TLR4:MD2:TIRAP:MYD88:IRAK4

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1640.5, 1491.8452927142598
23.76087355478069, 33.154707285740514

IRAK1{p}:TRAF6:TIFA

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p27

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1644.5, 1540.2437144430173
22.758671315837763, 31.75628555698293

TAK1:TAB1:TAB2

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p27

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
423.7627497555178, 376.29846948401513
1209.0848224989406, 1831.3677559746939

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1642.0, 1588.7941176470588
28.323529411764707, 47.20588235294118

IRAK1{p}:TRAF6:TIFA:TAK1:TAB1:TAB2

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28 p43

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1640.0, 1652.441176470588
23.73529411764706, 39.55882352941177

IRAK1{p}:TRAF6:TIFA:TAK1{p}:TAB1:TAB2{p}

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1486.0, 1700.6764705882354
27.794117647058826, 46.32352941176471

TRAF6:TIFA:TAK1{p}:TAB1:TAB2{p}

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p32 p45

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1642.0, 1709.0243902439024
36.21951219512195, 28.975609756097562

IRAK1{p}

--

e43

cso30:c:Protein

cso30:i:CC_Extracellular

--

p29

p31 p82

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1228.0, 1807.4146341463413
40.731707317073166, 32.58536585365854

IRAK1{p}

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1552.0, 1659.4117647058822
24.352941176470587, 40.588235294117645

(TRAF6)n:TIFA:TAK1{p}:TAB1:TAB2{p}

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1565.0, 1481.2058823529412
22.676470588235293, 37.79411764705882

(TRAF6)n{ub}:TIFA:TAK1{p}:TAB1:TAB2{p}

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34 p35 p36

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1247.0, 1411.0
34.0, 34.0

p38{active}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34 p51

p37 p55 p57 p62 p65

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1391.0, 1411.0
34.0, 34.0

JNK{active}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p52

p38 p56 p59 p60 p64

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1285.0, 1465.0
38.0, 38.0

IKK

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1160.0, 187.3137082601055
47.978910369068544, 31.186291739894546

lipoproteins

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
733.8428956660066, 1567.959466049854
573.252997430483, 519.8774855654486

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
795.7584894294479, 1580.2798066747703
335.198214512424, 503.86483200593716

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
741.3154673271115, 1574.898282592309
558.3078541082734, 505.99985248053866

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
742.382977564412, 1575.9657928296097
556.1728336336714, 503.86483200593716

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
733.8428956660066, 1567.959466049854
573.252997430483, 519.8774855654486

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
733.8428956660066, 1567.959466049854
573.252997430483, 519.8774855654486

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
742.382977564412, 1575.9657928296097
556.1728336336714, 503.86483200593716

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1152.306908687887, 1781.4615135099968
35.81369753852681, 32.420820929613825

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
1058.3660078054231, 1930.9129467320977
101.4134725435677, 91.80588040786154

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
733.8428956660066, 1567.959466049854
573.252997430483, 519.8774855654486

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1147.5, 311.85288313966237
25.39267704450778, 49.14711686033764

lipoproteins:TLR2

--

e6

cso30:c:Complex

cso30:i:CC_Extracellular

--

p1

p12

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
868.9554016877682, 1798.9887248521109
18.15408012182283, 8.740853391988793

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
868.349185565896, 1772.9214316115908
62.137152491937684, 111.846874485488

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
894.416478806417, 1845.6673662362991
9.699457949961001, 9.699457949961008

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
855.0, 1379.048780487805
42.4390243902439, 33.951219512195124

TFs{p}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37 p38

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
937.0, 1261.614107466291
45.22036627087945, 27.885892533708994

TFs

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37 p38

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1435.5, 1573.354940843193
24.21013164472588, 29.645059156807207

NF-kappaB:I-kappaB

--

e65

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p39

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1407.5, 1665.354940843193
24.21013164472588, 29.645059156807207

NF-kappaB:I-kappaB{p}

--

e66

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p39

p40

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1392.5, 1865.0961506415597
30.138143642726202, 36.90384935844026

NF-kappaB:IkappaB{p}{ub}

--

e67

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p40

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1510.0, 2004.4682028577179
42.21372509559267, 26.03179714228215

NF-kappaB{active}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
944.0, 953.8755846585595
23.020579981290926, 53.124415341440596

pellino3

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42 p51 p52 p53 p70 p77 p81

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
357.9069666114254, 298.2160455389012
1338.301943682141, 1896.3392855127029

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1641.0, 1763.0
30.0, 50.0

IRAK1{p}:TRAF6:TIFA:TAK1:TAB1:TAB2:pellino

--

e70

cso30:c:Complex

cso30:i:CC_Extracellular

--

p43

p44

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1638.0, 1844.205882352941
28.676470588235293, 47.794117647058826

IRAK1{p}:TRAF6:TIFA:TAK1:TAB1:TAB2:pellino{p}

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p46

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1173.0, 1179.6176470588234
29.029411764705884, 48.38235294117647

TRAF6:TIFA:TAK1{p}:TAB1:TAB2{p}:pellino

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1642.0, 1924.8235294117646
27.705882352941174, 46.17647058823529

IRAK1{p}{ub}:TRAF6:TIFA:TAK1:TAB1:TAB2:pellino{p}

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p30

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1107.0, 1044.6574585635358
34.50828729281768, 38.34254143646409

pellino3:NIK

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1267.5, 843.8866855524079
32.759206798866856, 40.113314447592074

pellino1:smad6

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
752.5, 993.6909524683429
31.75481739768765, 44.309047531657185

pellino1:IRAK1:TRAF6

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
228.0, 927.7117126182332
40.1972227812437, 24.788287381766953

TGF-beta

--

e77

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p47

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
610.5, 742.895684052658
27.85185802366272, 34.104315947342116

pellino1:MYD88

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1067.5, 636.2666222296285
32.448925179136815, 39.733377770371604

pellino2:Bcl10

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
362.68818888885903, 331.6846014809379
1283.849001472924, 1864.148750138688

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
757.0, 1241.0
30.0, 30.0

ERK{active}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p54 p58 p61 p63

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
506.0, 1494.0
36.0, 36.0

c-Jun{active}

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54 p55 p56

p69

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
476.0, 1592.0
32.0, 32.0

Elk-1

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57 p58 p59

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000000038

--

Go back
580.0, 1908.0
40.0, 40.0

CREB{active}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60 p61 p62

p67

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
503.5, 1998.955323002616
25.927550815053326, 42.04467699738379

CHOP

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p63 p64 p65

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
681.5, 2051.1640169048096
21.482189575367276, 34.83598309519017

CHOP{active}

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

p63 p64 p65

p66

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1030.0, 1940.0
60.0, 32.0

genes

--

e86

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66 p67 p68 p69

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1280.0, 969.5801104972377
39.97790055248619, 44.41988950276243

pellino3:IRAK1

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
997.0, 786.6353591160221
30.92817679558011, 34.3646408839779

pellino2:IRAK1

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
781.0, 851.9558011049725
37.83977900552486, 42.04419889502762

Pellino2:IRAK4

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
375.4381149620158, 365.15315742297423
1277.987526545868, 1839.7009063940295

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1252.5, 672.2464589235127
31.648725212464583, 38.75354107648725

pellino2:TRAF6

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
833.0, 791.0773480662983
30.530386740331494, 33.92265193370165

pellino1:TRAF6

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
805.5, 1057.6560573237794
29.680886518913507, 36.34394267622062

Pellino3:TRAF6

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
627.0, 1092.8232044198894
34.35911602209945, 38.1767955801105

pellino1:TAK1

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
507.5, 888.4252624562571
25.78603566072321, 31.574737543742703

TAK1:pellino2

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
611.5, 823.9766705549075
32.685719046825525, 40.02332944509248

TAK1:pellino3

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1193.0, 252.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000019397

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m3964*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR2 responds to lipoproteins, TLR3 to viral double-stranded RNA, TLR4 to lipopolysaccharide (LPS), TLR5 to flagellin, TLR7 and TLR8 to viral single stranded RNA, and TLR9 to unmethylated CpG islands of bacterial and viral DNA.

Go back
1731.0, 590.5
21.5, 21.5

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000022528

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m11*m6810*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
1755.0, 690.0
21.0, 21.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000016573

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m20*m1572*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
1240.0, 207.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e6

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m6810*m6*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
1351.0, 237.5
18.5, 18.5

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016573

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m22*m1572*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
804.0, 235.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016573

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
676.0, 203.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000016573

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m13*m1572*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
363.0, 240.5
22.5, 22.5

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016573

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
297.0, 500.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016573

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 17635639, 16751103 In the case of TLR2 and TLR4, MyD88 recruitment requires Mal, whereas the other TLRs and the IL-1R signal independently of Mal.

Go back
1759.0, 770.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000041132

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m11*m19005*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR4 can also initiate a Mal/MyD88-independent signalling pathway through the recruitment of TRAM and TRIF.

Go back
1766.0, 849.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000041125

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m28*m18998*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR4 can also initiate a Mal/MyD88-independent signalling pathway through the recruitment of TRAM and TRIF.

Go back
1051.0, 254.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR2 responds to lipoproteins, TLR3 to viral double-stranded RNA, TLR4 to lipopolysaccharide (LPS), TLR5 to flagellin, TLR7 and TLR8 to viral single stranded RNA, and TLR9 to unmethylated CpG islands of bacterial and viral DNA.

Go back
1763.0, 929.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 e30 MO000039077

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m21*m30*m17258*0.1

nodelay

--

true

0

false

PMID: 17635639 Binding of MyD88 to TLR4 allows the recruitment of IL-1R associated kinase (IRAK)-1 and IRAK-4 through the death domains (DD) of both kinases and the DD and intermediate domain of MyD88.

Go back
1750.0, 1026.0
19.0, 19.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17635639, 11960013, 15084582, 14625308 close proximity in the receptor complex enables IRAK-4 to phosphorylate IRAK-1, leading to its activation and IRAK?1 autophosphorylation.

Go back
1761.0, 1101.0
21.0, 21.0

p22

p22

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 17635639, 11960013, 15084582, 14625308 close proximity in the receptor complex enables IRAK-4 to phosphorylate IRAK-1, leading to its activation and IRAK?1 autophosphorylation.

Go back
1769.0, 1161.0
21.0, 21.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000019406 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1

m3973*m33*0.1

nodelay

--

true

0

false

PMID: 17635639 Active IRAK?1 also phosphorylates Tollip, supposedly a silencer for quiescent IRAK-1, which subsequently leaves the receptor complex

Go back
1727.0, 1263.0
25.0, 25.0

p24

p24

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e34

e36 e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17635639 Active IRAK?1 also phosphorylates Tollip, supposedly a silencer for quiescent IRAK-1, which subsequently leaves the receptor complex

Go back
1795.0, 1299.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 MO000061452 MO000000212

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m33*m36350*m183*0.1

nodelay

--

true

0

false

PMID: 17635639, 15492226 IRAK-1 in turn interacts with the signalling molecule TRAF6 and TIFA, which is an adaptor protein that has been suggested to promote the oligomerization and ubiquitination of TRAF6.

Go back
1762.0, 1414.0
19.0, 19.0

p26

p26

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e35

e37 e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17635639, 9466656 The IRAK-1/TRAF6/TIFA complex then leaves the receptor complex but remains at the membrane where it interacts with a preformed (but inactive) complex consisting of the mitogen activated protein kinase (MAPK) kinase kinase TAK1 and the adaptor molecules TAB1 and TAB2 or TAB3..

Go back
1755.0, 1495.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e38 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 17635639, 9466656 The IRAK-1/TRAF6/TIFA complex then leaves the receptor complex but remains at the membrane where it interacts with a preformed (but inactive) complex consisting of the mitogen activated protein kinase (MAPK) kinase kinase TAK1 and the adaptor molecules TAB1 and TAB2 or TAB3..

Go back
1740.0, 1632.0
23.0, 23.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17635639 After phosphorylation of TAK1 and TAB2, the newly formed TRAF6-TAB2/3-TAK1-TAB1 complex migrates to the cytosol while IRAK-1 has been suggested to remain at the membrane and to disappear by proteasomal degradation.

Go back
1538.0, 1710.0
27.0, 27.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e41

e42 e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17635639 After phosphorylation of TAK1 and TAB2, the newly formed TRAF6-TAB2/3-TAK1-TAB1 complex migrates to the cytosol while IRAK-1 has been suggested to remain at the membrane and to disappear by proteasomal degradation.

Go back
1730.0, 305.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018132 MO000016882

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m2828*m155666*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR2 responds to lipoproteins, TLR3 to viral double-stranded RNA, TLR4 to lipopolysaccharide (LPS), TLR5 to flagellin, TLR7 and TLR8 to viral single stranded RNA, and TLR9 to unmethylated CpG islands of bacterial and viral DNA. PMID: 17635639 Upon LPS-binding (mediated by MD-2 and CD14) to TLR4 and subsequent TLR4 clustering, Mal, MyD88, IRAK-1, Tollip and IRAK-4 are recruited to the cytoplasmic part of the receptor via TLR4/MyD88 TIR?TIR interactions

Go back
1770.0, 2026.0
27.0, 27.0

p30

p30

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e73

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c89 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 17635639 After phosphorylation of TAK1 and TAB2, the newly formed TRAF6-TAB2/3-TAK1-TAB1 complex migrates to the cytosol while IRAK-1 has been suggested to remain at the membrane and to disappear by proteasomal degradation.

Go back
1461.0, 1810.0
25.0, 25.0

p31

p31

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17635639, 15896328 A redistribution of IRAK-1 from the receptor complex to the nucleus has also been shown upon receptor triggering, but the function of nuclear IRAK-1 remains speculative.

Go back
1491.0, 1667.0
17.0, 17.0

p32

p32

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e42

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17635639 TIFA promotes the oligomerization and activation of TRAF6, leading to TRAF6 K63-linked polyubiquitination and subsequent TAK1 activation.

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1569.0, 1593.0
21.0, 21.0

p33

p33

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17635639 TIFA promotes the oligomerization and activation of TRAF6, leading to TRAF6 K63-linked polyubiquitination and subsequent TAK1 activation.

Go back
1253.0, 1365.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m47*m46*0.1

nodelay

--

true

0

false

PMID: 17635639, 11057907, 11460167 Active TAK1 then leads to the downstream activation of I¦ÊB kinases (IKK) and JNK or p38 MAPKs.

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1420.0, 1360.0
23.0, 23.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e46

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m49*m46*0.1

nodelay

--

true

0

false

PMID: 17635639, 11057907, 11460167 Active TAK1 then leads to the downstream activation of I¦ÊB kinases (IKK) and JNK or p38 MAPKs.

Go back
1344.0, 1524.0
23.0, 23.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 e46

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c104 : 1
stoichiometry:c103 : 1

m64*m46*0.1

nodelay

--

true

0

false

PMID: 17635639, 11057907, 11460167 Active TAK1 then leads to the downstream activation of I¦ÊB kinases (IKK) and JNK or p38 MAPKs.

Go back
948.0, 1340.0
23.0, 23.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e64 e47

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1

m66*m48*0.1

nodelay

--

true

0

false

PMID: 17635639 IKKs eventually activate NF-¦ÊB by phosphorylating the NF-¦ÊB inhibitory protein I¦ÊB¦Á, leading to its ubiquitination and proteasome-dependent degradation, whereas JNK and p38 further contribute to the innate immune response by phosphorylating and activating several other transcription factors.

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881.0, 1313.0
21.0, 21.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e64 e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m66*m63*0.1

nodelay

--

true

0

false

PMID: 17635639 IKKs eventually activate NF-¦ÊB by phosphorylating the NF-¦ÊB inhibitory protein I¦ÊB¦Á, leading to its ubiquitination and proteasome-dependent degradation, whereas JNK and p38 further contribute to the innate immune response by phosphorylating and activating several other transcription factors.

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1462.0, 1626.0
19.0, 19.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e65 MO000000248

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1

m67*m207*0.1

nodelay

--

true

0

false

PMID: 17635639 IKKs eventually activate NF-¦ÊB by phosphorylating the NF-¦ÊB inhibitory protein I¦ÊB¦Á, leading to its ubiquitination and proteasome-dependent degradation, whereas JNK and p38 further contribute to the innate immune response by phosphorylating and activating several other transcription factors

Go back
731.0, 246.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019399 MO000022185

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR2 responds to lipoproteins, TLR3 to viral double-stranded RNA, TLR4 to lipopolysaccharide (LPS), TLR5 to flagellin, TLR7 and TLR8 to viral single stranded RNA, and TLR9 to unmethylated CpG islands of bacterial and viral DNA.

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1396.0, 1740.0
23.0, 23.0

p40

p40

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17635639 IKKs eventually activate NF-¦ÊB by phosphorylating the NF-¦ÊB inhibitory protein I¦ÊB¦Á, leading to its ubiquitination and proteasome-dependent degradation, whereas JNK and p38 further contribute to the innate immune response by phosphorylating and activating several other transcription factors

Go back
1475.0, 1863.0
17.0, 17.0

p41

p41

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e67

MO000019479 e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17635639 IKKs eventually activate NF-¦ÊB by phosphorylating the NF-¦ÊB inhibitory protein I¦ÊB¦Á, leading to its ubiquitination and proteasome-dependent degradation, whereas JNK and p38 further contribute to the innate immune response by phosphorylating and activating several other transcription factors

Go back
1040.0, 1028.0
23.0, 23.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000000203

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c131 : 1

m71*m174*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243 Pellino-3 was also shown to bind the Ser/Thr kinase NIK.

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1399.0, 1164.0
21.0, 21.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041420 e40

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m19288*m40*0.1

nodelay

--

true

0

false

PMID: 17635639 Pellino proteins associate with IRAK-1, TRAF6 and TAK1 and become phosphorylated by IRAK-1. PMID: 17635639, 12874243 Based on the observation that Pellino-3 can simultaneously interact with endogenous IRAK-1, TRAF6 and TAK1 upon IL-1 stimulation, it was hypothesized that Pellino proteins might act as scaffold proteins that regulate signalling branch-points in TLR/IL-1R signalling to NF-¦ÊB and MAPKs.

Go back
1734.0, 1858.0
27.0, 27.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17635639 Pellino proteins associate with IRAK-1, TRAF6 and TAK1 and become phosphorylated by IRAK-1.

Go back
1265.0, 1193.0
21.0, 21.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041420 e42

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m19288*m42*0.1

nodelay

--

true

0

false

PMID: 17635639 Pellino proteins associate with IRAK-1, TRAF6 and TAK1 and become phosphorylated by IRAK-1. PMID: 17635639, 12874243 Based on the observation that Pellino-3 can simultaneously interact with endogenous IRAK-1, TRAF6 and TAK1 upon IL-1 stimulation, it was hypothesized that Pellino proteins might act as scaffold proteins that regulate signalling branch-points in TLR/IL-1R signalling to NF-¦ÊB and MAPKs.

Go back
1745.0, 1937.0
21.0, 21.0

p46

p46

cso30:i:ME_Ubiquitination

cso30:i:CC_Extracellular

--

e71

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c129 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 17635639 Pellino-1 and -2 also induce IRAK-1 polyubiquitination.

Go back
1204.0, 928.0
23.0, 23.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041419 MO000017765 e77

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c141 : 1
stoichiometry:c134 : 1

m19287*m2522*m79*0.1

nodelay

--

true

0

false

PMID: 17635639, 16951688 Pellino-1 was recently found to interact with Smad6, an anti-inflammatory protein induced by TGF-¦Â.

Go back
793.0, 909.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041419 e30 MO000000212 e75 MO000000214

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c138 : 1

m19287*m30*m183*m185*0.1

nodelay

--

true

0

false

PMID: 17635639, 16951688 This Pellino-1/Smad6 interaction completely abrogat-ed the formation of the Pellino-1/IRAK-1/TRAF6 signalling complex induced by IL-1.

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885.0, 748.0
23.0, 23.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041419 MO000016573

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m19287*m1572*0.1

nodelay

--

true

0

false

PMID: 17635639, 16951688 the same group also reported an interaction between Pellino-1 and the TLR/IL-1R adaptor protein MyD88.

Go back
625.0, 224.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000042126

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m14*m19940*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR2 responds to lipoproteins, TLR3 to viral double-stranded RNA, TLR4 to lipopolysaccharide (LPS), TLR5 to flagellin, TLR7 and TLR8 to viral single stranded RNA, and TLR9 to unmethylated CpG islands of bacterial and viral DNA.

Go back
953.0, 645.0
21.0, 21.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041433 MO000044192

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m19301*m21910*0.1

nodelay

--

true

0

false

PMID: 17635639, 15213237 Pellino-2 was also picked up via phage display as a Bcl-10 interacting protein and shown to interact with Bcl-10 in RAW264.7 macrophages treated with LPS.

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1180.0, 1336.0
23.0, 23.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e69

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m47*m71*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
1371.0, 1363.0
25.0, 25.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e69

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m49*m71*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
788.0, 1192.0
23.0, 23.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e69

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m82*m71*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
490.0, 1422.0
19.0, 19.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000049 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c163 : 1
stoichiometry:c158 : 1

m84*m83*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
540.0, 1422.0
18.0, 18.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000049 e47

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c164 : 1
stoichiometry:c160 : 1

m84*m48*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
584.0, 1404.0
23.0, 23.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000049 e48

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c165 : 1
stoichiometry:c162 : 1

m84*m63*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
564.0, 1560.0
23.0, 23.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e47

MO000000038

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c172 : 1
stoichiometry:c167 : 1

m87*m48*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
556.0, 1620.0
23.0, 23.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e80

MO000000038

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c173 : 1
stoichiometry:c169 : 1

m87*m83*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
558.0, 1670.0
19.0, 19.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e48

MO000000038

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c174 : 1
stoichiometry:c171 : 1

m87*m63*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
501.0, 268.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000042007

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m14*m19823*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR2 responds to lipoproteins, TLR3 to viral double-stranded RNA, TLR4 to lipopolysaccharide (LPS), TLR5 to flagellin, TLR7 and TLR8 to viral single stranded RNA, and TLR9 to unmethylated CpG islands of bacterial and viral DNA.

Go back
535.0, 1851.0
17.0, 17.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017189 e48

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c183 : 1
stoichiometry:c176 : 1

m2057*m63*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
590.0, 1842.0
19.0, 19.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017189 e80

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c182 : 1
stoichiometry:c178 : 1

m2057*m83*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
641.0, 1805.0
21.0, 21.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017189 e47

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c181 : 1
stoichiometry:c180 : 1

m2057*m48*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
557.0, 2085.0
21.0, 21.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e84 e80

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c192 : 1
stoichiometry:c185 : 1

m89*m83*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
586.0, 2026.0
19.0, 19.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e84 e48

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c191 : 1
stoichiometry:c187 : 1

m89*m63*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
621.0, 1985.0
21.0, 21.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e84 e47

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c190 : 1
stoichiometry:c189 : 1

m89*m48*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
905.0, 1942.0
25.0, 25.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
856.0, 1892.0
23.0, 23.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e83

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c195 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
936.0, 1844.0
23.0, 23.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000038

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
1020.0, 1808.0
23.0, 23.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e81

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c199 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 15917247 Overexpression of Pellino-3 has no effect on NF-¦ÊB activation, but activates ERK, JNK and p38 MAPKs, leading to the activation of Elk-1, c-Jun, CREB and CHOP dependent gene expression

Go back
261.0, 336.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19828*m16*0.1

nodelay

--

true

0

false

PMID: 17635639 TLR2 responds to lipoproteins, TLR3 to viral double-stranded RNA, TLR4 to lipopolysaccharide (LPS), TLR5 to flagellin, TLR7 and TLR8 to viral single stranded RNA, and TLR9 to unmethylated CpG islands of bacterial and viral DNA.

Go back
1054.0, 982.0
19.0, 19.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 e30

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m71*m30*0.1

nodelay

--

true

0

false

PMID: 17635639, 15917247, 16884718, 12496252, 12370331, 12860405, 16951688, 15917247 all mammalian Pellino proteins were shown to interact with IRAK-1 and IRAK-4.

Go back
1102.0, 782.0
19.0, 19.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041433 e30

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m19301*m30*0.1

nodelay

--

true

0

false

PMID: 17635639, 15917247, 16884718, 12496252, 12370331, 12860405, 16951688, 15917247 all mammalian Pellino proteins were shown to interact with IRAK-1 and IRAK-4.

Go back
1112.0, 836.0
23.0, 23.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041419 e30

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m19287*m30*0.1

nodelay

--

true

0

false

PMID: 17635639, 15917247, 16884718, 12496252, 12370331, 12860405, 16951688, 15917247 all mammalian Pellino proteins were shown to interact with IRAK-1 and IRAK-4.

Go back
1231.0, 775.0
17.0, 17.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041419 MO000039077

MO000041425

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c211 : 1
stoichiometry:c210 : 1

m19287*m17258*0.1

nodelay

--

true

0

false

PMID: 17635639, 15917247, 16884718, 12496252, 12370331, 12860405, 16951688, 15917247 all mammalian Pellino proteins were shown to interact with IRAK-1 and IRAK-4.

Go back
792.0, 700.0
15.0, 15.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041433 MO000039077

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c214 : 1
stoichiometry:c213 : 1

m19301*m17258*0.1

nodelay

--

true

0

false

PMID: 17635639, 15917247, 16884718, 12496252, 12370331, 12860405, 16951688, 15917247 all mammalian Pellino proteins were shown to interact with IRAK-1 and IRAK-4.

Go back
1177.0, 692.0
19.0, 19.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041433 MO000000212

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m19301*m183*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 12496252, 16951688, 15917247, 12804775 all three mammalian Pellino proteins also interact with TRAF6 and TAK1.

Go back
918.0, 834.0
19.0, 19.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041419 MO000000212

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1

m19287*m183*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 12496252, 16951688, 15917247, 12804775 all three mammalian Pellino proteins also interact with TRAF6 and TAK1.

Go back
864.0, 1012.0
15.0, 15.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000000212

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m71*m183*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 12496252, 16951688, 15917247, 12804775 all three mammalian Pellino proteins also interact with TRAF6 and TAK1.

Go back
635.0, 1035.0
17.0, 17.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016574 MO000041419

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m1573*m19287*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 12496252, 16951688, 15917247, 12804775 all three mammalian Pellino proteins also interact with TRAF6 and TAK1.

Go back
1818.0, 433.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000022131

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m3961*m6438*0.1

nodelay

--

true

0

false

PMID: 17635639 Upon LPS-binding (mediated by MD-2 and CD14) to TLR4 and subsequent TLR4 clustering, Mal, MyD88, IRAK-1, Tollip and IRAK-4 are recruited to the cytoplasmic part of the receptor via TLR4/MyD88 TIR?TIR interactions

Go back
587.0, 963.0
17.0, 17.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016574 MO000041433

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c228 : 1
stoichiometry:c229 : 1

m1573*m19301*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 12496252, 16951688, 15917247, 12804775 all three mammalian Pellino proteins also interact with TRAF6 and TAK1.

Go back
679.0, 967.0
17.0, 17.0

p81

p81

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016574 e69

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1
stoichiometry:c232 : 1

m1573*m71*0.1

nodelay

--

true

0

false

PMID: 17635639, 12874243, 12496252, 16951688, 15917247, 12804775 all three mammalian Pellino proteins also interact with TRAF6 and TAK1.

Go back
1721.0, 1741.0
30.0, 30.0

p82

p82

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Extracellular

--

e43

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17635639, 15896328 A redistribution of IRAK-1 from the receptor complex to the nucleus has also been shown upon receptor triggering, but the function of nuclear IRAK-1 remains speculative.

Go back
1827.0, 554.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 e18

e11 MO000018132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m19*m18*0.1

nodelay

--

true

0

false

PMID: 17635639 Upon LPS-binding (mediated by MD-2 and CD14) to TLR4 and subsequent TLR4 clustering, Mal, MyD88, IRAK-1, Tollip and IRAK-4 are recruited to the cytoplasmic part of the receptor via TLR4/MyD88 TIR?TIR interactions

Go back
1189.0, 219.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.2987830845308, 278.6626102817692

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1418.1513543886333, 1383.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1448.990097800444, 1387.3027095282619

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1323.0, 1503.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1359.0, 1547.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1374.8975240392217, 1502.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
960.0, 1290.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.0703033307765, 1358.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.7611400011626, 1356.9402850002907

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
908.5775375331502, 1290.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.7354436625493, 1334.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0540812353584, 200.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.8409232936405, 1327.587426188283

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1455.0, 1603.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1438.0455126623185, 1644.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1395.0, 1604.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1411.229656050255, 1695.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1408.0, 1763.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1423.0, 1874.364331469646

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1492.0, 1879.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1487.0, 1880.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.0, 987.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.8384987355416, 271.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.0, 1057.3464746087222

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1364.0, 1119.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1419.9188109582683, 1191.9744476966537

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1414.0, 1185.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1671.0, 1802.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1674.9964381120228, 1869.238699645135

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1288.8818240754583, 1119.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1283.167731382596, 1221.3461199205917

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1210.0, 1204.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1678.0, 1948.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.0, 197.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1670.0, 1958.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.0, 1044.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 868.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1216.0, 959.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1227.0, 888.9135706981983

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
821.7453331767936, 864.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.9973714472759, 901.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.9901453653008, 929.8907412882335

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.8089875327071, 930.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.973018970699, 866.0

c139

c139

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
636.0, 253.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.0, 783.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
268.0, 940.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
914.4900559996742, 772.677517837603

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.9682433538957, 701.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 760.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 653.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.7684722451426, 570.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
974.0, 656.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1208.3343588757587, 1317.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1202.0, 1359.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.2405150182823, 245.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.0, 997.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1390.5298221281348, 1333.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1389.0, 1388.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
967.0, 990.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
784.0, 1166.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.7927985842801, 1215.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.5763999991956, 997.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
505.3861999450876, 1374.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
503.0, 1441.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 1374.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.2620256460636, 197.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.272706637531, 1440.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.0, 1371.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.7846753031397, 1427.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.7223731857939, 1266.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.9999241670621, 1428.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.9990630550878, 1416.1224346385982

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0, 1580.1513543886333

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.0, 1574.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 1613.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.0, 1596.806548684808

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 297.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 1623.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 1605.9042304960183

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.8306568051777, 1432.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.8096158288165, 1271.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.6631282978516, 1433.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
549.488312483317, 1796.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.0, 1868.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.0, 1796.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.0, 1861.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 1786.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.1614465426102, 289.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.3636881022716, 1826.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.7559412321395, 1439.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.2208693514233, 1271.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
559.1537114204434, 1436.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.0, 2040.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 2072.7274901227747

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0, 2023.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 2039.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0, 1999.6180287380535

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0, 2006.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.97469620148183, 356.91836865251787

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.9487971491404, 1443.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.4058631839085, 1441.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.8817927215804, 1271.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.0, 1965.5777087639997

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
930.0, 1955.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0, 1907.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 1905.7090627680855

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.0, 1599.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
959.0, 1866.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1034.0, 1831.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1210.993552273537, 280.418803460505

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 318.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 1523.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
967.0, 981.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.8756224939966, 904.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1073.0, 992.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 661.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.7917877774028, 795.8132962339117

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.941481130629, 793.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 851.0749093837886

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.946105112698, 849.9270455964814

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 789.8182046393428

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 357.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1248.0, 764.3942594085579

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1255.1554175279994, 791.5777087639997

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.020613557655, 667.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.0, 715.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.6309552485045, 712.4017747594895

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.0, 654.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1196.0947889724464, 717.8726052753764

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1196.0, 694.9751304122016

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.9156885130728, 846.1583934409375

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
943.3021878545934, 855.9277203903443

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1668.0, 445.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.3104923889621, 818.2491077284276

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.2208294496276, 986.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.2450846217688, 1026.3924546899568

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.4715290310506, 1027.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 1046.342394784387

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.243908517701, 868.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 1052.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 987.6970138105231

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.1357775331956, 668.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.9792745494693, 921.3149107106393

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1733.0, 418.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 986.5536798306425

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.998959620257, 976.1290154777461

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.3210675663101, 871.2780842410625

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1678.0, 1732.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1674.6385352726525, 449.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1667.0, 507.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1657.0, 411.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1668.0, 565.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1640.67160477189, 368.6420651637032

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1660.0, 569.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1177.0918708781414, 273.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1581.0, 601.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1673.9726042969965, 607.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1667.0, 660.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1587.0, 700.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1676.3795279064104, 706.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1266.0838332662724, 236.17694417335483

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.0, 236.3148177390106

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.0, 230.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1315.0, 263.07934577905587

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1367.3941730389497, 263.2442797696987

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 202.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1361.0, 256.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 263.2596640086902

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.8640882424468, 258.10905008486196

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 258.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 232.32765345276295

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0128312239469, 224.84970105650234

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.0, 222.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.9542853302145, 269.28132604366476

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.49299744214596, 258.8026753882664

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
377.0, 263.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1046.871832634471, 279.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
325.418803460505, 484.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
325.91135026031645, 513.1876603296358

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.0, 519.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1660.0, 584.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1601.0, 781.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1677.6312486754741, 784.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1670.0, 823.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1592.0, 861.1838594701584

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1694.599030549249, 865.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1669.0, 774.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.1393547112737, 285.8458558686447

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1597.0, 904.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1592.0, 942.4204706649821

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1668.1554175279994, 947.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1661.0, 1008.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1672.598358248393, 1039.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1665.0, 1076.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1676.9328032894898, 1114.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1591.0, 1172.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1678.458890471601, 1176.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1669.0, 1133.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1635.0, 321.64808384839876

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1671.0, 1230.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1672.9425461726091, 1156.9610580860128

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1599.0, 1276.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1669.0, 1144.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1509.0, 1312.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1588.0, 1315.2221972416921

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1673.3383680645795, 1318.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1666.0, 1385.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1678.7759850884524, 1426.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1670.5727049087313, 1431.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1760.9995749090037, 316.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1664.0, 1508.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1667.0, 1517.1007091149047

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1675.859891942764, 1520.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1670.0, 1617.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1671.6845141153165, 1647.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1572.0977344098767, 1678.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1522.0, 1724.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1565.0, 1724.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1667.0, 1879.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1604.3399289514184, 1962.1820501234472

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1663.097574993403, 327.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1493.062579700479, 1734.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1276.999891495263, 1823.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1500.0, 1692.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1508.0, 1676.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1568.0, 1621.8094964814716

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1577.324058133142, 1526.9934339508338

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1242.0, 1317.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1264.0, 1386.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1281.4313306822162, 1382.9623173853508

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1412.0, 1333.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back