1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17667934.csml convertedTime:2009.07.01.11:06

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immuneresponse.
Authors Thompson AJ, Locarnini SA.
Affiliation Department of Molecular Research and Development, Victorian Infectious DiseasesReference Laboratory, North Melbourne, Victoria, Australia.alexander.thompson@svhm.org.au
Abstract The antiviral innate immune response follows the detection of viral componentsby host pattern recognition receptors (PRRs). Two families of PRRs have emergedas key sensors of viral infection: Toll-like receptors (TLRs) and retinoic acidinducible gene-I like RNA helicases (RLHs). TLRs patrol the extracellular andendosomal compartments; signalling results in a type-1 interferon responseand/or the production of pro-inflammatory cytokines. In contrast, RLHs surveythe cytoplasm for the presence of viral double-stranded RNA. In the face of suchhost defence, viruses have developed strategies to evade TLR/RLH signalling.Such host-virus interactions provide the opportunity for manipulation of PRRsignalling as a novel therapeutic approach.
PMID 17667934
Model Abstract

Entity

G010228:IFN-beta MO000000065:RIP1 MO000007694:IRF-3 MO000016963:TRAF3 MO000019398:TLR3 MO000019399:TLR5 MO000022185:flagellin MO000022224:dsRNA MO000041125:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 e1: e10:RIG-I:dsRNA:RIG-I e100:MDA5:dsRNA:IPS:TRAF3:FADD:caspase-8:caspase-10 e101:RIG-I:dsRNA:RIG-I:TRAF3:FADD:caspase-8:caspase-10 e102:Poly I:C e103:TLR3:Poly I:C e104:Imiquimod e105:TLR7:Imiquimod e106:TLR8:Imiquimod e107:R848 e108:TLR7:R848 e109:TLR8:R848 e11:TLR2:TLR1:Triacyl Lipopeptides e110:Loxoribine e111:TLR8:Loxoribine e112:TLR7:Loxoribine e113:F protein e114:F protein:TLR4 e115:TLR2 e116:HA e117:TLR2:HA e118:HSV-1 e119:TLR2:HSV1 e12:diacyl lipopeptides e120:core e121:TLR2:core e122:NS3 e123:TLR2:NS3 e124:glycoprotein B e125:TLR2:glycoprotein B e126:glycoprotein H e127:TLR2:glycoprotein H e128:NS3/4a e129:Pam-3-Cys e13:TLR2:TLR6 e130:TLR2:Pam-3-Cys e131:TNF-alpha e132:Proinflammtory cytokine e133:Proinflammtory cytokine e134:CD150 e135:IRAk2 e136:A52R e137:IRAK2:A52R:TRAF6 e138:A52R:TRAF6 e139:p38{active} e14:TLR2:TLR6:diacyl lipopeptides e140:IL-10 e141:IL-10 e142:protein remnants e143:NS3/4a inhibitor e144:NS3 e145:TBK1 e146:NS3:TBK1 e147:GBV-B encoded protease e148: e149: e15: e150: e151: e152: e153: e154: e155: e156: e157:3 ABC precursor e158:3 ABC precursor e159:protein remnants e16: e160:V proteins e161:V proteins:MDA5:dsRNA e162:IRF-3{active} e163:NS1 e164:RIG-I:dsRNA:NS1 e165:dsRNA:TLR3:TRIF:RIP1 e166:MyD88 e17: e18:TLR5:flagellin e19:ssRNA e2: e20:TLR7:ssRNA e21:TLR8:ssRNA e22:CpG DNA e23:TLR9:CpG DNA e24:dsRNA:TLR3:TRIF e25:dsRNA:TLR3:TRIF:TRAF3 e26:TBK-1:Ikk-i e27:TBK-1:Ikk-i{active} e28:IRF-3{p}:IRF-3{p} e29:IRF-3{p}:IRF-3{p} e3: e30:dsRNA:TLR3:TRIF:RIP1 e31:TRAF6 e32:dsRNA:TLR3:TRIF:TRAF6 e33:LPS e34:TLR4 e35:LPS:TLR4 e36:TRAM e37:LPS:TLR4:TRAM e38:LPS:TLR4:TRAM:TRIF e39:Mal e4: e40:LPS:TLR4:Mal e41:MyD88 e42:LPS:TLR4:Mal:MyD88 e43:IRAK4 e44:IRAK4{active} e45:IRAK1 e46:IRAK1{active} e47:TRAF6{active} e48:TAK1:TAB1:TAB2 e49:TAK1{active}:TAB1:TAB2 e5:TLR2:TLR1 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Triacyl lipopeptides e60: e61: e62: e63:IKK complex e64:IKK complex{p} e65:JNK e66:JNK{p} e67:ERK e68:ERK{p} e69:p38 e7: e70:p38{p} e71:NF-kappaB e72:NF-kappaB{active} e73:AP-1 e74:AP-1{active} e75:TLR7:ssRNA:MyD88 e76:IRAK-1:IRAK-4:TRAF6:TRAF3:IKK-alpha:OPN e77:TLR7:ssRNA:MyD88:IRAK-1:IRAK-4:TRAF6:TRAF3:IKK-alpha:OPN e78:IRF-7 e79:IRF-7{active} e8: e80:IRF-7{active} e81:IFN-alpha e82:dsRNA e83:RIG-I e84:RIG-I:dsRNA e85:MDA5 e86:MDA5:dsRNA e87:IPS e88:RIG-I:dsRNA:RIG-I:IPS e89:MDA5:dsRNA:IPS e9: e90:TRAF3 e91:RIG-I:dsRNA:RIG-I:IPS:TRAF3 e92:MDA5:dsRNA:IPS:TRAF3 e93:IRF-7{p} e94:Type I IFN e95:FADD e96:RIG-I:dsRNA:RIG-I:TRAF3:FADD e97:MDA5:dsRNA:IPS:TRAF3:FADD e98:caspase-8 e99:Caspase-10

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93
Model Detail
534.0, 1254.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p14

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
599.0, 171.0
18.0, 18.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
664.0, 464.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p88 p90

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
777.0, 257.0
21.5, 21.5

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
900.0, 276.0
23.0, 23.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p57

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
532.0, 88.0
24.0, 24.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
612.0, 32.0
24.0, 24.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
1177.0, 277.0
22.0, 22.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
896.0, 172.0
24.0, 24.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p19

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
904.0, 320.0
24.0, 24.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3 p81

p8

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
546.0, 558.0
27.0, 27.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p12 p51

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
960.0, 464.0
20.0, 20.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p59 p61 p62

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
945.0, 561.0
21.0, 21.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
946.0, 362.0
20.0, 20.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p58 p60 p63

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
92.65252695467275, 61.275710899030024
1069.967919867105, 1589.4360163610504

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
849.5, 1009.0
21.40135804734814, 29.862360066067172

RIG-I:dsRNA:RIG-I

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p43 p82 p84

p44

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
992.0, 1296.0
24.176470588235293, 40.294117647058826

MDA5:dsRNA:IPS:TRAF3:FADD:caspase-8:caspase-10

--

e100

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p55

p71

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
992.0, 1352.0
24.52941176470588, 40.88235294117647

RIG-I:dsRNA:RIG-I:TRAF3:FADD:caspase-8:caspase-10

--

e101

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p56

p75

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1184.0, 204.0
40.67283431455004, 23.047939444911687

Poly I:C

--

e102

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p57

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
721.5, 452.0
20.424249068186803, 39.530804648103484

TLR3:Poly I:C

--

e103

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p57

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1184.0, 425.0
40.37005887300252, 22.876366694701428

Imiquimod

--

e104

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p58 p59

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
998.5, 454.0
18.106555579916684, 35.04494628370971

TLR7:Imiquimod

--

e105

cso30:c:Complex

cso30:i:CC_Extracellular

--

p58

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
973.5, 604.0
20.397062047796535, 39.47818460863845

TLR8:Imiquimod

--

e106

cso30:c:Complex

cso30:i:CC_Extracellular

--

p59

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1197.0, 475.0
45.54247266610597, 25.807401177460047

R848

--

e107

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p60 p61

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
713.5, 560.0
21.01556676167507, 40.675290506467874

TLR7:R848

--

e108

cso30:c:Complex

cso30:i:CC_Extracellular

--

p60

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
704.5, 626.0
22.225389169041875, 43.016882262661696

TLR8:R848

--

e109

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p61

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
372.5, 72.0
23.555698293264815, 32.86841622316021

TLR2:TLR1:Triacyl Lipopeptides

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1186.0, 587.0
44.407064760302774, 25.164003364171574

Loxoribine

--

e110

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p62 p63

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
889.5, 699.0
21.987502740627054, 42.556456917342686

TLR8:Loxoribine

--

e111

cso30:c:Complex

cso30:i:CC_Extracellular

--

p62

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
813.5, 727.0
21.987502740627054, 42.556456917342686

TLR7:Loxoribine

--

e112

cso30:c:Complex

cso30:i:CC_Extracellular

--

p63

--

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
17.0, 146.5
29.945663111290003, 18.46649225196217

F protein

--

e113

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p64

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
128.5, 163.0
22.01468976101732, 42.60907695680772

F protein:TLR4

--

e114

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p64

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
717.5, 83.0
21.77328646748682, 33.49736379613357

TLR2

--

e115

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p65 p66 p67 p68 p69 p70 p72

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
761.0, 26.5
29.99396256792111, 18.49627691688469

HA

--

e116

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p65 p76

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
777.5, 79.0
21.396185047138783, 41.411971058978295

TLR2:HA

--

e117

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p65

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
911.0, 30.5
26.239999999999995, 19.68

HSV-1

--

e118

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p66

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
861.5, 79.0
21.396185047138783, 41.411971058978295

TLR2:HSV1

--

e119

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p66

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
112.5, 19.0
15.74864157778225, 25.538337693700942

diacyl lipopeptides

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1039.5, 26.0
16.85812034614611, 27.3374924532099

core

--

e120

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p67

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
949.5, 83.0
21.396185047138783, 41.411971058978295

TLR2:core

--

e121

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p67

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
652.0, 10.0
15.748362956033676, 36.34237605238541

NS3

--

e122

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p68

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
481.5, 75.0
21.396185047138783, 41.411971058978295

TLR2:NS3

--

e123

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p68

--

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
1137.0, 30.5
30.102636345341114, 18.563292412960354

glycoprotein B

--

e124

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p69

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
1109.5, 99.0
21.396185047138783, 41.411971058978295

TLR2:glycoprotein B

--

e125

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p69

--

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
1217.0, 118.5
30.102636345341114, 18.563292412960354

glycoprotein H

--

e126

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p70

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
1113.5, 171.0
21.396185047138783, 41.411971058978295

TLR2:glycoprotein H

--

e127

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p70

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
1002.0, 1511.0
19.94117647058824, 33.235294117647065

NS3/4a

--

e128

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p81 p82

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
373.0, 19.5
29.06419802777219, 17.922922117126184

Pam-3-Cys

--

e129

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p72

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
211.5, 89.0
24.291784702549577, 29.74504249291785

TLR2:TLR6

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
421.5, 84.0
20.512606884455163, 39.701819776364836

TLR2:Pam-3-Cys

--

e130

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p72

p73

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
452.0, 1190.0
39.34256055363321, 20.982698961937718

TNF-alpha

--

e131

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p73

--

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
460.0, 1303.0
47.38754325259516, 25.27335640138408

Proinflammtory cytokine

--

e132

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p74

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
52.0, 1297.0
16.61178671655753, 38.334892422825064

Proinflammtory cytokine

--

e133

cso30:c:Protein

cso30:i:CC_Extracellular

--

p74

--

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
585.0, 1302.0
37.94117647058823, 20.235294117647058

CD150

--

e134

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p76

--

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
282.0, 203.5
28.665727510565503, 17.677198631515395

IRAk2

--

e135

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p77

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
363.5, 210.0
16.992151338297447, 27.554840008049908

A52R

--

e136

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p77 p78

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
267.5, 423.0
24.265920352358236, 33.859423747476605

IRAK2:A52R:TRAF6

--

e137

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p77

p30

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
464.5, 226.0
22.699550074987503, 27.795367438760202

A52R:TRAF6

--

e138

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p78

p79

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
307.5, 887.0
16.299657878848862, 26.43187764137653

p38{active}

--

e139

cso30:c:Protein

cso30:i:CC_Cytosol

--

p79

p80

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
118.5, 97.0
26.68067535327583, 37.22884933015232

TLR2:TLR6:diacyl lipopeptides

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
435.0, 1241.0
42.66435986159169, 22.75432525951557

IL-10

--

e140

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p80

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
60.5, 1239.0
15.651841416784064, 25.381364459649827

IL-10

--

e141

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p80

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
408.0, 645.0
23.744974152785762, 22.953475014359558

protein remnants

--

e142

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p81 p82 p84

--

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
1199.0, 1156.0
42.590412111017656, 24.134566862910006

NS3/4a inhibitor

--

e143

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p81 p82

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
564.0, 198.5
31.51539545180117, 19.434493861944052

NS3

--

e144

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p83

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
440.0, 339.5
23.360000000000003, 17.520000000000003

TBK1

--

e145

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p83

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
523.5, 346.0
22.511748041992995, 27.565405765705712

NS3:TBK1

--

e146

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p83

p11

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
297.0, 1399.0
14.605238540692236, 33.704396632366695

GBV-B encoded protease

--

e147

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p84

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
789.6219188767549, 1080.625
268.53042121684825, 374.31513260530386

--

e148

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false true false

--

Go back
790.4356474258968, 1081.438728549142
266.9029641185644, 372.68767550701983

--

e149

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false true false

--

Go back
702.0, 227.23626571596535
323.5092636489483, 540.0959740579901

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
822.9847893915754, 1109.5123634945385
201.8046801872073, 316.5404056162246

--

e150

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false true false

--

Go back
823.7985179407179, 1110.3260920436815
200.17722308892345, 314.9129485179403

--

e151

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false true false

--

Go back
790.4356474258968, 1081.438728549142
266.9029641185644, 372.68767550701983

--

e152

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false true false

--

Go back
823.7985179407179, 1110.3260920436815
200.17722308892345, 314.9129485179403

--

e153

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false true false

--

Go back
790.4356474258968, 1081.438728549142
266.9029641185644, 372.68767550701983

--

e154

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false true false

--

Go back
899.5855551359643, 1288.7094889018751
3.60691826292471, 3.606918262924707

--

e155

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false true false

--

Go back
890.117394695787, 1261.8830343213726
23.106820121861453, 41.59227621935054

--

e156

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false true false

--

Go back
793.5, 1514.0
15.718856912859732, 25.49003823706983

3 ABC precursor

--

e157

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p85

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false false false

--

Go back
940.5, 1419.0
15.718856912859732, 25.49003823706983

3 ABC precursor

--

e158

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p85

p86

true true true true

csml-variable:Double

m159

0

false

infinite

0

unit false false false

--

Go back
820.0, 1237.0
23.744974152785762, 22.953475014359558

protein remnants

--

e159

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p86

--

true true true true

csml-variable:Double

m160

0

false

infinite

0

unit false false false

--

Go back
702.0, 227.23626571596535
323.5092636489483, 540.0959740579901

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
950.0, 771.5
27.04769571342323, 16.679412356610992

V proteins

--

e160

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p87

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false false false

--

Go back
1043.5, 879.0
24.37639933932832, 34.01358047348137

V proteins:MDA5:dsRNA

--

e161

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p87

p71 p88

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false false false

--

Go back
500.0, 932.0
24.0, 24.0

IRF-3{active}

--

e162

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88 p90

--

true true true true

csml-variable:Double

m163

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1040.5, 951.0
15.614610585630919, 25.320990138860942

NS1

--

e163

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p89

true true true true

csml-variable:Double

m164

0

false

infinite

0

unit false false false

--

Go back
904.5, 980.0
23.626720499174162, 32.967516975591856

RIG-I:dsRNA:NS1

--

e164

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p89

p90

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false false false

--

Go back
723.0, 269.0
19.235294117647058, 32.05882352941177

dsRNA:TLR3:TRIF:RIP1

--

e165

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p15

p91

true true true true

csml-variable:Double

m166

0

false

infinite

0

unit false false false

--

Go back
987.0, 202.5
26.399999999999995, 19.800000000000004

MyD88

--

e166

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p93

true true true true

csml-variable:Double

m167

0

false

infinite

0

unit false false false

--

Go back
702.0, 227.23626571596535
323.5092636489483, 540.0959740579901

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
628.5, 79.0
22.02828327121245, 42.63538697654023

TLR5:flagellin

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1175.0, 361.5
41.12256084192063, 21.246656434992328

ssRNA

--

e19

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p5 p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
92.65252695467275, 61.275710899030024
1069.967919867105, 1589.4360163610504

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
988.5, 395.0
22.02828327121245, 42.63538697654023

TLR7:ssRNA

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p34 p93

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
996.5, 535.0
22.02828327121245, 42.63538697654023

TLR8:ssRNA

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1178.0, 529.5
60.0, 13.0

CpG DNA

--

e22

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
933.5, 643.0
21.987502740627054, 42.55645691734269

TLR9:CpG DNA

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
831.5, 223.0
24.928794274178756, 34.78436410350524

dsRNA:TLR3:TRIF

--

e24

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

p9 p15 p16 p81

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
706.0, 311.0
20.558823529411768, 34.26470588235295

dsRNA:TLR3:TRIF:TRAF3

--

e25

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p9

p10

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
565.0, 327.0
22.922651933701648, 25.469613259668506

TBK-1:Ikk-i

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p10 p48 p49

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
481.0, 383.0
22.922651933701648, 25.469613259668506

TBK-1:Ikk-i{active}

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10 p48 p49

p11 p50

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
623.5, 693.0
24.700049991668052, 30.244959173471095

IRF-3{p}:IRF-3{p}

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
543.5, 1041.0
24.700049991668052, 30.244959173471095

IRF-3{p}:IRF-3{p}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
114.05188535201484, 83.16876897562851
1027.1692030724212, 1545.6499002078547

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
812.0, 360.0
23.47058823529412, 39.11764705882353

dsRNA:TLR3:TRIF:RIP1

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
337.0, 392.0
14.289055191768005, 32.97474275023385

TRAF6

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16 p24 p77 p78

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
716.0, 360.0
23.47058823529412, 39.11764705882353

dsRNA:TLR3:TRIF:TRAF6

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p92

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
38.0, 199.5
27.27711813242101, 16.820889514992956

LPS

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
118.5, 220.0
26.365553602811953, 40.562390158172235

TLR4

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17 p64

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
124.5, 287.0
22.01468976101732, 42.60907695680772

LPS:TLR4

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18 p20 p80

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
247.0, 238.5
25.59999999999999, 19.2

TRAM

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
115.5, 350.0
25.52064599008992, 35.61020370710222

LPS:TLR4:TRAM

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
121.0, 414.0
21.441176470588236, 35.735294117647065

LPS:TLR4:TRAM:TRIF

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
200.5, 164.0
15.23485610786879, 24.70517206681425

Mal

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
153.64069838709787, 121.48162060967576
947.9915770022554, 1469.0241969397584

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
124.5, 477.0
22.072123325380804, 30.798311616810427

LPS:TLR4:Mal

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
230.0, 458.0
12.19738072965388, 28.147801683816642

MyD88

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21 p34

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
121.0, 538.0
21.0, 35.0

LPS:TLR4:Mal:MyD88

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
304.0, 490.5
24.800000000000004, 18.6

IRAK4

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
220.0, 622.5
24.800000000000004, 18.6

IRAK4{active}

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
206.0, 677.5
27.2, 20.399999999999995

IRAK1

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
354.0, 589.5
27.2, 20.399999999999995

IRAK1{active}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
497.0, 448.0
14.289055191768005, 32.97474275023385

TRAF6{active}

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
377.5, 542.0
20.76215819416407, 28.970453294182423

TAK1:TAB1:TAB2

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p25 p92

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
509.5, 614.0
20.76215819416407, 28.970453294182423

TAK1{active}:TAB1:TAB2

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25 p92

p26 p27 p28 p29

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
280.5, 86.0
22.291284785869017, 27.29545075820696

TLR2:TLR1

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
359.32238305577215, 1018.9015466279134
416.6313175920378, 386.55586272490893

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
404.32166875472586, 1028.0623586106622
243.6168225770948, 374.64962465329984

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
364.75333132978363, 1024.0609164589432
405.7694210440147, 376.23712306284773

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
365.5291810832141, 1024.8546656637182
404.217721537154, 374.64962465329984

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
359.32238305577215, 1018.9015466279134
416.6313175920378, 386.55586272490893

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
359.32238305577215, 1018.9015466279134
416.6313175920378, 386.55586272490893

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
365.5291810832141, 1024.8546656637182
404.217721537154, 374.64962465329984

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
663.4554864004249, 1177.6513875827018
26.02883554067871, 24.106561166167165

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
595.1807080985643, 1288.7762762510529
73.70572657587257, 68.26243161055896

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
359.32238305577215, 1018.9015466279134
416.6313175920378, 386.55586272490893

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
260.5, 15.0
15.74864157778225, 25.538337693700942

Triacyl lipopeptides

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
457.52004038914765, 1190.6837778854742
13.194101652723907, 6.499277652343745

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
457.079451987982, 1171.301393944511
45.16031111947705, 83.16394970018276

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
476.0247532381045, 1225.391767733248
7.049414418650066, 7.2120498384982294

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
350.0, 659.0
20.382352941176475, 33.97058823529412

IKK complex

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p26 p91

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
294.0, 719.0
20.382352941176475, 33.97058823529412

IKK complex{p}

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26 p91

p30

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
399.5, 786.0
16.813443348762327, 27.265043268263234

JNK

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
471.5, 850.0
16.813443348762327, 27.265043268263234

JNK{p}

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

p31

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
567.5, 622.0
16.925135842221774, 27.446166230629903

ERK

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
543.5, 838.0
16.925135842221774, 27.446166230629903

ERK{p}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p28

p32

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
695.5, 735.0
16.299657878848862, 26.43187764137653

p38

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p29 p79

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
106.71034478444716, 67.67172707887302
1049.3051823066182, 1521.1408451073046

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
648.5, 896.0
15.197625276715636, 24.644797746025354

p38{p}

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

p33

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
225.0, 907.5
22.879999999999992, 17.159999999999997

NF-kappaB

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30 p36 p71 p75

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
345.0, 1003.5
22.879999999999992, 17.159999999999997

NF-kappaB{active}

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

p30 p36 p71 p75

p74

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
307.0, 780.5
25.429663916280944, 15.681626081706582

AP-1

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31 p32 p33 p37

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
379.0, 932.5
25.429663916280944, 15.681626081706582

AP-1{active}

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31 p32 p33 p37

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
744.5, 408.0
22.474582492200405, 31.35988254725638

TLR7:ssRNA:MyD88

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34 p93

p35

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
509.0, 174.0
21.882352941176475, 36.47058823529412

IRAK-1:IRAK-4:TRAF6:TRAF3:IKK-alpha:OPN

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
820.0, 496.0
23.470588235294123, 39.117647058823536

TLR7:ssRNA:MyD88:IRAK-1:IRAK-4:TRAF6:TRAF3:IKK-alpha:OPN

--

e77

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p35

p36 p37 p38

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
796.0, 872.0
24.0, 24.0

IRF-7

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p50

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
820.0, 924.0
24.0, 24.0

IRF-7{active}

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p39

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
110.45909620572047, 94.51839310489804
1006.6109646663392, 1495.3193380819705

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
680.0, 1108.0
24.0, 24.0

IRF-7{active}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

p40

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
683.0, 1263.0
49.2560553633218, 26.26989619377163

IFN-alpha

--

e81

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1033.0, 789.0
22.0, 22.0

dsRNA

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p42

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1023.0, 654.5
25.6, 19.2

RIG-I

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41 p43

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
901.5, 799.0
20.503082819530082, 25.105815697383775

RIG-I:dsRNA

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p43 p89 p90

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
871.0, 862.5
25.599999999999998, 19.200000000000006

MDA5

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42 p87

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
928.5, 930.0
22.969005165805697, 28.12531244792535

MDA5:dsRNA

--

e86

cso30:c:Complex

cso30:i:CC_Extracellular

--

p42

p45 p87 p88

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
920.0, 1102.0
15.188961646398498, 35.05144995322732

IPS

--

e87

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p44 p45 p86

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
875.0, 1159.0
25.411764705882355, 42.352941176470594

RIG-I:dsRNA:RIG-I:IPS

--

e88

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p44

p46 p82 p84

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
992.5, 1148.0
23.63461185538631, 32.97852817030648

MDA5:dsRNA:IPS

--

e89

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p45

p47

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
111.455766662449, 118.36505913092316
1002.0152334519025, 1475.7085996561477

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
708.0, 806.0
15.82132834424696, 36.51075771749298

TRAF3

--

e90

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p46 p47

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
973.0, 1081.0
22.411764705882355, 37.35294117647059

RIG-I:dsRNA:RIG-I:IPS:TRAF3

--

e91

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p46

p48 p53

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
876.0, 1216.0
24.176470588235293, 40.294117647058826

MDA5:dsRNA:IPS:TRAF3

--

e92

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p47

p49 p54

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
714.0, 878.0
27.0, 27.0

IRF-7{p}

--

e93

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

p52

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
608.0, 1219.0
48.944636678200695, 26.103806228373703

Type I IFN

--

e94

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p51 p52

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1028.0, 1454.5
24.799999999999994, 18.599999999999994

FADD

--

e95

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p53 p54

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
936.0, 1276.0
24.52941176470588, 40.88235294117647

RIG-I:dsRNA:RIG-I:TRAF3:FADD

--

e96

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p53

p56

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
848.0, 1368.0
24.176470588235293, 40.294117647058826

MDA5:dsRNA:IPS:TRAF3:FADD

--

e97

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p54

p55

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
665.0, 1422.5
30.00603743207889, 18.503723083115318

caspase-8

--

e98

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p55 p56

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
637.0, 1514.5
30.344133628496678, 18.712215737572954

Caspase-10

--

e99

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p55 p56

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
325.0, 17.0
22.0, 22.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 17667934,12697090 Following the discovery of TLR4, TLR2 was found to be the receptor for components of the Gram-positive bacterial cell wall, recognizing triacyl lipopeptides in combination with TLR1, and diacyl lipopeptides in combination with TLR6.

Go back
641.0, 329.0
21.0, 21.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m25*m26*0.1

nodelay

--

true

0

false

PMID: 17667934,16497588 TRIF interacts with tumour necrosis factor (TNF) receptor associated factor 3 (TRAF3) 3 to activate TRAF-family-member-associated NFkB activator (TANK)-binding kinase 1 (TBK1), and the non-canonical inhibitor of NFkB (IkB) kinase , IKKi

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570.0, 446.0
19.0, 19.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e27 MO000007694 e146

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c251 : 1
stoichiometry:c33 : 1

m27*m977*0.1

nodelay

--

true

0

false

PMID: 17667934 These kinases directly phosphorylate interferon regulatory factor-3 (IRF-3). PMID: 17667934,17190786 TBK1/IKKi phosphorylate IRF-3 and IRF-7, inducing a type-1 IFN response. PMID: 17667934,15841462 Otsuka et al showed that NS3 binds TBK1 to act as a competitive inhibitor of the TBK1-IRF-3 interaction, to reduce IRF-3 activation and therefore downstream IFNb induction

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621.0, 625.0
21.0, 21.0

p12

p12

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17667934 Phosphorylated IRF-3 forms a dimer before translocating to the nucleus, where it induces expression of IFNb.

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540.0, 956.0
23.0, 23.0

p13

p13

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m28*0.1

nodelay

--

true

0

false

Go back
533.0, 1133.0
21.0, 21.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m29*0.1

nodelay

--

true

0

false

Go back
694.0, 170.0
19.0, 19.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000000065

e165

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c276 : 1

m24*m30*0.1

nodelay

--

true

0

false

PMID: 17667934,15665823 TRIF is also able to interact with receptor-interacting protein 1 and TRAF6 to induce a late phase proinflammatory cytokine response

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618.0, 206.0
19.0, 19.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e24

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m32*m24*0.1

nodelay

--

true

0

false

PMID: 17667934,15665823 TRIF is also able to interact with receptor-interacting protein 1 and TRAF6 to induce a late phase proinflammatory cytokine response

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41.0, 273.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m34*m35*0.1

nodelay

--

true

0

false

Go back
225.0, 329.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m36*m37*0.1

nodelay

--

true

0

false

PMID: 17667934,16497588 TLR4 uses the adaptor TRAM to recruit TRIF and induce a type-1 IFN response via the MyD88-independent pathway described above PMID: 17667934 Figure2

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233.0, 389.0
21.0, 21.0

p18

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000041125

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m38*m18998*0.1

nodelay

--

true

0

false

PMID: 17667934,16497588 TLR4 uses the adaptor TRAM to recruit TRIF and induce a type-1 IFN response via the MyD88-independent pathway described above PMID: 17667934 Figure2

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213.0, 21.0
22.0, 22.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m12*m13*0.1

nodelay

--

true

0

false

PMID: 17667934,12697090 Following the discovery of TLR4, TLR2 was found to be the receptor for components of the Gram-positive bacterial cell wall, recognizing triacyl lipopeptides in combination with TLR1, and diacyl lipopeptides in combination with TLR6.

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197.0, 257.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m36*m40*0.1

nodelay

--

true

0

false

PMID: 17667934,12447441 In contrast, TLR4 uses the coadaptor Mal to recruit MyD88 to its TIR domain

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197.0, 517.0
21.0, 21.0

p20

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m41*m42*0.1

nodelay

--

true

0

false

PMID: 17667934,12447441 In contrast, TLR4 uses the coadaptor Mal to recruit MyD88 to its TIR domain

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221.0, 557.0
22.0, 22.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e42 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m43*m44*0.1

nodelay

--

true

0

false

PMID: 17667934,17457343,15928677 Stimulation of the MyD88-dependent pathway initiates a downstream signalling cascade involving sequential activation of primary and secondary kinases including the interleukin-1 receptor (IL-1R) associated kinases -4 and -1 (IRAK-4, and -1), TRAF6 and TGF-b-activated kinase (TAK1). PMID: 17667934 Figure2

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289.0, 677.0
22.0, 22.0

p22

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m45*m46*0.1

nodelay

--

true

0

false

PMID: 17667934,17457343,15928677 Stimulation of the MyD88-dependent pathway initiates a downstream signalling cascade involving sequential activation of primary and secondary kinases including the interleukin-1 receptor (IL-1R) associated kinases -4 and -1 (IRAK-4, and -1), TRAF6 and TGF-b-activated kinase (TAK1). PMID: 17667934 Figure2

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409.0, 469.0
22.0, 22.0

p22

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e46 e31

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m47*m32*0.1

nodelay

--

true

0

false

PMID: 17667934,17457343,15928677 Stimulation of the MyD88-dependent pathway initiates a downstream signalling cascade involving sequential activation of primary and secondary kinases including the interleukin-1 receptor (IL-1R) associated kinases -4 and -1 (IRAK-4, and -1), TRAF6 and TGF-b-activated kinase (TAK1). PMID: 17667934 Figure2

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485.0, 545.0
22.0, 22.0

p22

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m48*m49*0.1

nodelay

--

true

0

false

PMID: 17667934,17457343,15928677 Stimulation of the MyD88-dependent pathway initiates a downstream signalling cascade involving sequential activation of primary and secondary kinases including the interleukin-1 receptor (IL-1R) associated kinases -4 and -1 (IRAK-4, and -1), TRAF6 and TGF-b-activated kinase (TAK1). PMID: 17667934 Figure2

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409.0, 705.0
22.0, 22.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e49 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m63*m64*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively.

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493.0, 761.0
22.0, 22.0

p26

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e49 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m63*m66*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively.

Go back
541.0, 765.0
22.0, 22.0

p26

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e49 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m63*m68*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively.

Go back
645.0, 797.0
22.0, 22.0

p26

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e69 e49

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c84 : 1
stoichiometry:c83 : 1

m70*m63*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively.

Go back
1037.0, 277.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17667934,11607032 TLR3 recognises doublestranded RNA

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257.0, 821.0
21.0, 21.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e71 e64 e137

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c87 : 1
stoichiometry:c227 : 1
stoichiometry:c86 : 1

m72*m65*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively. PMID: 17667934,12566418 A52R inhibits NF-kB induction by multiple TLRs via interaction with IRAK2 and TRAF6

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337.0, 857.0
21.0, 21.0

p30

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m67*m74*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively.

Go back
433.0, 893.0
21.0, 21.0

p30

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m69*m74*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively.

Go back
561.0, 897.0
21.0, 21.0

p30

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m71*m74*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 Activated TAK1, in a complex with the TAK-1 binding proteins, TAB1 and TAB2, phosphorylates the IKK complex and the MAP kinases (JNK, ERK and p38), leading to activation of transcription factors nuclear factor-kappa B (NF-KappaB), and/or activating protein-1 (AP-1), respectively.

Go back
629.0, 517.0
21.0, 21.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 e20

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m42*m20*0.1

nodelay

--

true

0

false

PMID: 17667934,16497588 In contrast, TLR7/8 and TLR9 are able to use MyD88 to induce expression of both proinflammatory cytokines and type-1 IFN

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653.0, 401.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e76 e75

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m77*m76*0.1

nodelay

--

true

0

false

PMID: 17667934,16306936,16306937,16604075,15800576,15361868,16612387,16125763 Following nucleic acid recognition,MyD88 forms a signalling complex with IRAK-1, IRAK-4, TRAF6, TRAF3, IKKa and a precursor of osteopontin (OPN)

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365.0, 761.0
21.0, 21.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e77 e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m78*m72*0.1

nodelay

--

true

0

false

PMID: 17667934 The MyD88- IRAK-4- TRAF6 complex activates NF-KappaB and AP-1 as described above.

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437.0, 801.0
21.0, 21.0

p36

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e77 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m78*m74*0.1

nodelay

--

true

0

false

PMID: 17667934 The MyD88- IRAK-4- TRAF6 complex activates NF-KappaB and AP-1 as described above.

Go back
837.0, 805.0
21.0, 21.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e77 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m78*m79*0.1

nodelay

--

true

0

false

PMID: 17667934 In addition, the recruitment of IRAK-1, TRAF-3, IKKa and OPN allows TLR7/8 and TLR9 to activate IRF-7, which translocates to the nucleus to regulate the expression of type-1 IFN genes, especially IFNa

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706.0, 1022.0
19.0, 19.0

p39

p39

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 17667934 In addition, the recruitment of IRAK-1, TRAF-3, IKKa and OPN allows TLR7/8 and TLR9 to activate IRF-7, which translocates to the nucleus to regulate the expression of type-1 IFN genes, especially IFNa

Go back
532.0, 4.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019399 MO000022185

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17667934,17283206,11323673,11489966 TLR5 recognises bacterial flagellin

Go back
697.0, 1193.0
21.0, 21.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 17667934 In addition, the recruitment of IRAK-1, TRAF-3, IKKa and OPN allows TLR7/8 and TLR9 to activate IRF-7, which translocates to the nucleus to regulate the expression of type-1 IFN genes, especially IFNa

Go back
957.0, 709.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e83 e82

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m84*m83*0.1

nodelay

--

true

0

false

PMID: 17667934,15208624 It was recognized that TLR-independent mechanisms existed to detect intracellular viral infection, and in 2004 Yoneyama and colleagues identified RIG-I as a cytosolic sensor of dsRNA produced during viral replication, triggering a type-1 interferon and proinflammatory cytokine response

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1002.0, 914.0
19.0, 19.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e82 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c226 : 1
stoichiometry:c121 : 1

m83*m86*0.1

nodelay

--

true

0

false

PMID: 17667934 MDA-5 was identified soon after as a second CARD-containing helicase PMID: 17667934 Figure 2

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850.0, 946.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e84 e83

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m85*m84*0.1

nodelay

--

true

0

false

PMID: 17667934 Following dsRNA binding, RIG-I undergoes a conformational shift allowing self-association and CARD interaction with a downstream adaptor protein, IFN-b promoter stimulator (IPS-1).

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758.0, 1046.0
19.0, 19.0

p43

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e87 e10

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m88*m10*0.1

nodelay

--

true

0

false

PMID: 17667934 Following dsRNA binding, RIG-I undergoes a conformational shift allowing self-association and CARD interaction with a downstream adaptor protein, IFN-b promoter stimulator (IPS-1).

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1017.0, 1057.0
21.0, 21.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e86 e87

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m87*m88*0.1

nodelay

--

true

0

false

PMID: 17667934,16127453 Like RIG-I, MDA5 associates with IPS-1 via a CARD?CARD interaction following dsRNA binding

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677.0, 941.0
21.0, 21.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e88 e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m89*m91*0.1

nodelay

--

true

0

false

PMID: 17667934,16858409 IPS-1 interacts with TRAF3 via its non-CARD region to activate TBK-1 and IKKi

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769.0, 993.0
21.0, 21.0

p46

p47

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e89 e90

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m90*m91*0.1

nodelay

--

true

0

false

PMID: 17667934,16858409 IPS-1 interacts with TRAF3 via its non-CARD region to activate TBK-1 and IKKi

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777.0, 793.0
21.0, 21.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e26 e91

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c137 : 1
stoichiometry:c139 : 1

m26*m92*0.1

nodelay

--

true

0

false

PMID: 17667934,16858409 IPS-1 interacts with TRAF3 via its non-CARD region to activate TBK-1 and IKKi

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628.0, 984.0
23.0, 23.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e92 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m93*m26*0.1

nodelay

--

true

0

false

PMID: 17667934,16858409 IPS-1 interacts with TRAF3 via its non-CARD region to activate TBK-1 and IKKi

Go back
1037.0, 353.0
22.0, 22.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m19940*m19*0.1

nodelay

--

true

0

false

PMID: 17667934,14976262,11812998,11130078 TLR7/8 recognise single-stranded viral RNA, and TLR-9 recognises unmethylated CpG DNA motifs present in both viruses and bacteria

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738.0, 802.0
19.0, 19.0

p50

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e27 e78

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m27*m79*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 TBK1/IKKi phosphorylate IRF-3 and IRF-7, inducing a type-1 IFN response.

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608.0, 1144.0
23.0, 23.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 TBK1/IKKi phosphorylate IRF-3 and IRF-7, inducing a type-1 IFN response.

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656.0, 1144.0
23.0, 23.0

p51

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 TBK1/IKKi phosphorylate IRF-3 and IRF-7, inducing a type-1 IFN response.

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1058.0, 1130.0
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e91 e95

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m92*m96*0.1

nodelay

--

true

0

false

PMID: 17667934,16127453 IPS-1 interacts with FADD, an adaptor involved in death receptor signalling via its death domain

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826.0, 1290.0
19.0, 19.0

p53

p54

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e92 e95

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m93*m96*0.1

nodelay

--

true

0

false

PMID: 17667934,16127453 IPS-1 interacts with FADD, an adaptor involved in death receptor signalling via its death domain

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778.0, 1386.0
19.0, 19.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e97 e98 e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m98*m99*m100*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 FADD forms a complex with caspase-10, and caspase-8; the caspase cleavage products produced are specifically involved in downstream NF-kB activation and proinflammatory cytokine production

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914.0, 1390.0
19.0, 19.0

p55

p56

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e96 e98 e99

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m97*m99*m100*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 FADD forms a complex with caspase-10, and caspase-8; the caspase cleavage products produced are specifically involved in downstream NF-kB activation and proinflammatory cytokine production

Go back
1008.0, 240.0
23.0, 23.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019398 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m3965*m103*0.1

nodelay

--

true

0

false

PMID: 17667934,11607032 Poly(I:C), a synthetic dsRNA analogue, was first demonstrated to be a ligand for TLR3 by Alexopoulou and colleagues in 2001, inducing type-1 interferons and proinflammatory cytokines in a MyD88-independent manner

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1042.0, 394.0
19.0, 19.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m19940*m105*0.1

nodelay

--

true

0

false

PMID: 17667934,11812998,12032557 TLR7 and 8 also recognize synthetic antiviral compounds, including imidazoquinolines (imiquimod and R848) and certain guanine nucleotide analogues (loxoribine).

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1046.0, 474.0
19.0, 19.0

p58

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e104 MO000042007

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m105*m19823*0.1

nodelay

--

true

0

false

PMID: 17667934,11812998,12032557 TLR7 and 8 also recognize synthetic antiviral compounds, including imidazoquinolines (imiquimod and R848) and certain guanine nucleotide analogues (loxoribine).

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1045.0, 429.0
22.0, 22.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e19

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19823*m19*0.1

nodelay

--

true

0

false

PMID: 17667934,14976262,11812998,11130078 TLR7/8 recognise single-stranded viral RNA, and TLR-9 recognises unmethylated CpG DNA motifs present in both viruses and bacteria

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1030.0, 326.0
19.0, 19.0

p58

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e107 MO000042126

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m108*m19940*0.1

nodelay

--

true

0

false

PMID: 17667934,11812998,12032557 TLR7 and 8 also recognize synthetic antiviral compounds, including imidazoquinolines (imiquimod and R848) and certain guanine nucleotide analogues (loxoribine).

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806.0, 574.0
19.0, 19.0

p58

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e107 MO000042007

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m108*m19823*0.1

nodelay

--

true

0

false

PMID: 17667934,11812998,12032557 TLR7 and 8 also recognize synthetic antiviral compounds, including imidazoquinolines (imiquimod and R848) and certain guanine nucleotide analogues (loxoribine).

Go back
1046.0, 578.0
19.0, 19.0

p58

p62

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e110 MO000042007

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m111*m19823*0.1

nodelay

--

true

0

false

PMID: 17667934,11812998,12032557 TLR7 and 8 also recognize synthetic antiviral compounds, including imidazoquinolines (imiquimod and R848) and certain guanine nucleotide analogues (loxoribine).

Go back
814.0, 622.0
19.0, 19.0

p58

p63

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e110

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m19940*m111*0.1

nodelay

--

true

0

false

PMID: 17667934,11812998,12032557 TLR7 and 8 also recognize synthetic antiviral compounds, including imidazoquinolines (imiquimod and R848) and certain guanine nucleotide analogues (loxoribine).

Go back
66.0, 122.0
19.0, 19.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e113 e34

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m114*m35*0.1

nodelay

--

true

0

false

PMID: 17667934 The F protein of RSV activates TLR4

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684.0, 24.0
23.0, 23.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e115 e116

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m116*m117*0.1

nodelay

--

true

0

false

PMID: 17667934,17082626,14739339,12163593,15521019,12663765,16973959,17082589 TLR2 has been shown to be activated by a number of viruses or viral proteins, including the haemaglutinin protein (HA) of measles virus (MV), HSV-1, the core and NS3 proteins of hepatitis C virus (HCV), the envelope glycoproteins B and H of human CMV and vaccinia virus (VV).

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840.0, 28.0
23.0, 23.0

p65

p66

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e115 e118

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m116*m119*0.1

nodelay

--

true

0

false

PMID: 17667934,17082626,14739339,12163593,15521019,12663765,16973959,17082589 TLR2 has been shown to be activated by a number of viruses or viral proteins, including the haemaglutinin protein (HA) of measles virus (MV), HSV-1, the core and NS3 proteins of hepatitis C virus (HCV), the envelope glycoproteins B and H of human CMV and vaccinia virus (VV).

Go back
976.0, 28.0
23.0, 23.0

p65

p67

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e115 e120

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m116*m121*0.1

nodelay

--

true

0

false

PMID: 17667934,17082626,14739339,12163593,15521019,12663765,16973959,17082589 TLR2 has been shown to be activated by a number of viruses or viral proteins, including the haemaglutinin protein (HA) of measles virus (MV), HSV-1, the core and NS3 proteins of hepatitis C virus (HCV), the envelope glycoproteins B and H of human CMV and vaccinia virus (VV).

Go back
496.0, 28.0
23.0, 23.0

p65

p68

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e122 e115

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m123*m116*0.1

nodelay

--

true

0

false

PMID: 17667934,17082626,14739339,12163593,15521019,12663765,16973959,17082589 TLR2 has been shown to be activated by a number of viruses or viral proteins, including the haemaglutinin protein (HA) of measles virus (MV), HSV-1, the core and NS3 proteins of hepatitis C virus (HCV), the envelope glycoproteins B and H of human CMV and vaccinia virus (VV).

Go back
1072.0, 64.0
23.0, 23.0

p65

p69

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e115 e124

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m116*m125*0.1

nodelay

--

true

0

false

PMID: 17667934,17082626,14739339,12163593,15521019,12663765,16973959,17082589 TLR2 has been shown to be activated by a number of viruses or viral proteins, including the haemaglutinin protein (HA) of measles virus (MV), HSV-1, the core and NS3 proteins of hepatitis C virus (HCV), the envelope glycoproteins B and H of human CMV and vaccinia virus (VV).

Go back
1045.0, 525.0
22.0, 22.0

p5

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000042012

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m22*m19828*0.1

nodelay

--

true

0

false

PMID: 17667934,14976262,11812998,11130078 TLR7/8 recognise single-stranded viral RNA, and TLR-9 recognises unmethylated CpG DNA motifs present in both viruses and bacteria

Go back
1040.0, 132.0
23.0, 23.0

p65

p70

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e115 e126

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m116*m127*0.1

nodelay

--

true

0

false

PMID: 17667934,17082626,14739339,12163593,15521019,12663765,16973959,17082589 TLR2 has been shown to be activated by a number of viruses or viral proteins, including the haemaglutinin protein (HA) of measles virus (MV), HSV-1, the core and NS3 proteins of hepatitis C virus (HCV), the envelope glycoproteins B and H of human CMV and vaccinia virus (VV).

Go back
441.0, 1417.0
21.0, 21.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e100 e71 e161

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c212 : 1
stoichiometry:c264 : 1
stoichiometry:c213 : 1

m101*m72*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 FADD forms a complex with caspase-10, and caspase-8; the caspase cleavage products produced are specifically involved in downstream NF-kB activation and proinflammatory cytokine production PMID: 17667934,17049367,15563593 The V proteins of paramyxoviruses have been shown to interact with MDA5, but not RIG-I, to inhibit dsRNA-induced activation of IRF3 and NF-kB

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449.0, 33.0
21.0, 21.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e129 e115

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m130*m116*0.1

nodelay

--

true

0

false

PMID: 17667934 When patient PBMCs were stimulated with the specific TLR2 ligand Pam-3-Cys, relative suppression of TNFa induction was noted in the HBeAg-positive group, confirming functional significance.

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481.0, 1109.0
21.0, 21.0

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e130

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c210 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17667934 When patient PBMCs were stimulated with the specific TLR2 ligand Pam-3-Cys, relative suppression of TNFa induction was noted in the HBeAg-positive group, confirming functional significance.

Go back
240.0, 1304.0
23.0, 23.0

p74

p74

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e72 e132

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c216 : 1

m73*m133*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 FADD forms a complex with caspase-10, and caspase-8; the caspase cleavage products produced are specifically involved in downstream NF-kB activation and proinflammatory cytokine production

Go back
433.0, 1001.0
21.0, 21.0

p71

p75

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e101 e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m102*m72*0.1

nodelay

--

true

0

false

PMID: 17667934,17190786 FADD forms a complex with caspase-10, and caspase-8; the caspase cleavage products produced are specifically involved in downstream NF-kB activation and proinflammatory cytokine production

Go back
570.0, 1174.0
19.0, 19.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e116

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c220 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 17667934,12163593 The proinflammatory response to the HA protein of measles leads to the upregulation of CD150, an entry receptor for MV, and therefore the HA-TLR2 interaction may contribute to MV spread and pathogenesis

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321.0, 301.0
21.0, 21.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e135 e136 e31

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m136*m137*m32*0.1

nodelay

--

true

0

false

PMID: 17667934,12566418 A52R inhibits NF-kB induction by multiple TLRs via interaction with IRAK2 and TRAF6

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384.0, 288.0
23.0, 23.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e136 e31

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m137*m32*0.1

nodelay

--

true

0

false

PMID: 17667934,15998638 Interestingly, the A52R-TRAF6 interaction has been shown to simultaneously activate the MAP kinase p38 to enhance TLR-induced IL-10 induction the immunoregulatory role of IL-10 supports that this may be another virulence mechanism.

Go back
201.0, 793.0
21.0, 21.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e138 e69

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m139*m70*0.1

nodelay

--

true

0

false

--

Go back
844.0, 332.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041446 MO000041125

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17667934,11057907 TLR3 signals via the MyD88-independent pathway using the alternate adaptor protein TRIF

Go back
297.0, 1261.0
21.0, 21.0

p80

p80

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e140 e139 e35

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c236 : 1
stoichiometry:c237 : 1
stoichiometry:c235 : 1

m141*m140*m36*0.1

nodelay

--

true

0

false

PMID: 17667934,15998638 Interestingly, the A52R-TRAF6 interaction has been shown to simultaneously activate the MAP kinase p38 to enhance TLR-induced IL-10 induction the immunoregulatory role of IL-10 supports that this may be another virulence mechanism.

Go back
762.0, 702.0
19.0, 19.0

p81

p81

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e128 e24 e143

MO000041446 e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c247 : 1
stoichiometry:c240 : 1
stoichiometry:c241 : 1

m129*m24*0.1

nodelay

--

true

0

false

PMID: 17667934,15710891 NS3/4a was found to inhibit the dsRNA-TLR3 response by cleaving the adaptor TRIF between amino acids (aa) 372 and 373.

Go back
1014.0, 1234.0
19.0, 19.0

p82

p82

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e128 e88 e143

e10 e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c243 : 1
stoichiometry:c246 : 1
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m129*m89*0.1

nodelay

--

true

0

false

PMID: 17667934,16177806,15710891,15710892 NS3/4a also interfered with the cytoplasmic response to dsRNA, by cleaving IPS-1 at aa Cys- 508, the downstream adaptor of RIG-I. PMID: 17667934,16585524 The effect was able to be blocked using a specific pharmacological inhibitor of the NS3/4a protease

Go back
509.0, 253.0
21.0, 21.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e144 e145

e146

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m145*m146*0.1

nodelay

--

true

0

false

PMID: 17667934,15841462 Otsuka et al showed that NS3 binds TBK1 to act as a competitive inhibitor of the TBK1-IRF-3 interaction, to reduce IRF-3 activation and therefore downstream IFNb induction

Go back
409.0, 1481.0
21.0, 21.0

p84

p84

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e147 e88

e10 e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c254 : 1
stoichiometry:c255 : 1

m148*m89*0.1

nodelay

--

true

0

false

PMID: 17667934 GBV-B encodes a similar NS3/4a protease, which has also been shown to disrupt RIG-I signalling by targeting IPS-1 for cleavage

Go back
849.0, 1481.0
19.0, 19.0

p85

p85

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e157

e158

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c257 : 1

m158*0.1

nodelay

--

true

0

false

PMID: 17667934,17438296 Yang et al found that the 3ABC precursor of the 3C(pro) cysteine protease of HAV was targeted to the mitochondrial membrane where it cleaved IPS-1, disrupting signalling activity

Go back
950.0, 1206.0
19.0, 19.0

p86

p86

cso30:i:ME_Cleavage

cso30:i:CC_Cytoplasm

--

e87 e158

e159

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c258 : 1
stoichiometry:c260 : 1

m88*m159*0.1

nodelay

--

true

0

false

PMID: 17667934,17438296 Yang et al found that the 3ABC precursor of the 3C(pro) cysteine protease of HAV was targeted to the mitochondrial membrane where it cleaved IPS-1, disrupting signalling activity

Go back
986.0, 822.0
19.0, 19.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e160 e85 e86

e161

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c262 : 1
stoichiometry:c119 : 1
stoichiometry:c263 : 1

m161*m86*m87*0.1

nodelay

--

true

0

false

PMID: 17667934,17049367,15563593 The V proteins of paramyxoviruses have been shown to interact with MDA5, but not RIG-I, to inhibit dsRNA-induced activation of IRF3 and NF-kB

Go back
746.0, 938.0
19.0, 19.0

p88

p88

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e86 MO000007694 e161

e162

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c266 : 1
stoichiometry:c268 : 1
stoichiometry:c267 : 1

m87*m977*0.1

nodelay

--

true

0

false

PMID: 17667934,17049367,15563593 The V proteins of paramyxoviruses have been shown to interact with MDA5, but not RIG-I, to inhibit dsRNA-induced activation of IRF3 and NF-kB

Go back
973.0, 1021.0
21.0, 21.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e163 e84

e164

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c271 : 1

m164*m85*0.1

nodelay

--

true

0

false

PMID: 17667934,17079289 More recently it has been shown that NS1 also directly interacts with RIG-I to inhibit downstream activation of IRF-3.

Go back
657.0, 225.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000016963

e25 e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c42 : 1

m24*m1872*0.1

nodelay

--

true

0

false

PMID: 17667934,16497588 TRIF interacts with tumour necrosis factor (TNF) receptor associated factor 3 (TRAF3) 3 to activate TRAF-family-member-associated NFkB activator (TANK)-binding kinase 1 (TBK1), and the non-canonical inhibitor of NFkB (IkappaB) kinase , IKKi

Go back
673.0, 973.0
21.0, 21.0

p90

p90

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000007694 e84 e164

e162

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c274 : 1
stoichiometry:c272 : 1
stoichiometry:c275 : 1
stoichiometry:c273 : 1

m977*m85*0.1

nodelay

--

true

0

false

PMID: 17667934,17079289 More recently it has been shown that NS1 also directly interacts with RIG-I to inhibit downstream activation of IRF-3.

Go back
397.0, 421.0
21.0, 21.0

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e165 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1

m166*m64*0.1

nodelay

--

true

0

false

PMID: 17667934 Figure2

Go back
425.0, 509.0
21.0, 21.0

p91

p92

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e32 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c281 : 1
stoichiometry:c282 : 1

m33*m49*0.1

nodelay

--

true

0

false

PMID: 17667934 Figure2

Go back
844.0, 400.0
23.0, 23.0

p93

p93

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e166 e20

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c284 : 1
stoichiometry:c285 : 1

m167*m20*0.1

nodelay

--

true

0

false

PMID: 17667934 Figure2

Go back
301.0, 45.87281235127005

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 35.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 209.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.9364913754995, 414.00603411802103

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0, 418.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.9803223755673, 523.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
244.0, 787.7473463091134

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.6465269501284, 782.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.33643421370834, 525.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.0, 790.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.23074484714516, 822.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.0, 535.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
562.548799857063, 22.648701704232646

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 832.8993262705642

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0520088417358, 826.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.1510741622848, 946.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.182592802198, 1041.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.0, 1132.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
708.0, 1214.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.1676940130167, 674.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.5074104802507, 735.802450327407

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.159575575166, 730.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.0, 848.1393022092209

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.0, 26.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.9579993949138, 811.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
958.714609183337, 927.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.7141238899308, 824.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.1307727011595, 674.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 965.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.431392107625, 1062.9621632876547

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.5684758930026, 1028.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 1065.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
950.0, 958.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 1077.6470069584452

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.0, 365.67365518322754

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.992328318485, 1078.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.274327305744, 968.0151036127305

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.7523067384537, 843.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 957.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.5098677696539, 1015.6499055497528

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 843.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.0, 1014.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
799.4146815552946, 820.6716254964845

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.0, 352.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.6943618770515, 414.47788287693487

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1066.9893198795369, 365.4132406834243

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.7582976381943, 1012.553558166614

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.0, 352.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.9148908172727, 415.76744444189495

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 408.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.0856580228888, 827.1754418849364

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.9081978823488, 821.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 585.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.0, 1167.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.7630890794532, 905.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
641.466355478943, 1167.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.3517178529796, 375.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
995.0, 1105.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1041.0, 1156.9712776443341

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.8541937776859, 1149.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.0745328934241, 1251.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.2203329797528, 1312.0306518087618

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0, 1309.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.945204834583, 1389.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 1401.55720425993

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 1410.5047326640743

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.0, 1322.8047765030715

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
980.0, 446.9711254108328

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
927.8144626837994, 1317.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 1402.0501931339627

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 1408.3037548537081

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 1378.6825973242132

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0, 258.5029885994706

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.8505099974172, 220.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.3596099683606, 261.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.0, 375.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.8270453177151, 407.6544973842325

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.2664073870042, 413.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1074.1818190961828, 382.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.602146308199, 442.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 475.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.6285450965239, 493.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1055.1264124976476, 349.14461562302455

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.0, 343.2065506721577

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.3298080947449, 344.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.7804253938315, 493.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.4968356241563, 481.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.7211226860248, 590.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.9779617653992, 589.5934021147817

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0015420618655, 451.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.0, 484.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.1122393267752, 596.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.6251730423828, 382.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.973139442575, 602.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.0, 641.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
47.0, 141.72597146266097

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
84.68516064610886, 148.1006753912829

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
85.0, 139.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.5777087639997, 54.155417527999326

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
715.0, 36.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.0, 536.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.0, 44.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.0, 49.49193643417343

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 40.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 51.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.0, 44.777236102634866

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.0, 40.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.2065506721576, 51.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.9774825043141, 29.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.7207902974823, 45.09508882444243

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.24, 51.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 28.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.0, 542.672543938498

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.0, 77.52737884982281

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1102.0866522822412, 48.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.0, 87.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.0, 102.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.9671456517417, 129.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.0, 151.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
469.8389052305903, 1318.0

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.0, 31.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.8297355978042, 47.6417187543783

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.383083722649, 54.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.2680368629482, 547.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.94028500029066, 1130.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.0, 124.0

c211

c211

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
240.0, 925.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.791685539076, 1028.7967854227923

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.59391091181044, 1021.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
271.0, 1316.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
77.0, 1316.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.72861497326176, 1022.3273248712799

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
248.0, 921.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.0, 1012.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
874.8193133235189, 334.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 1193.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.3412392075273, 45.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
299.0, 221.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.34514884422515, 238.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0201739403162, 329.93468620245943

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.0090476818295, 322.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.0, 877.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.1208239631262, 457.0

c227

c227

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
376.0, 238.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 318.1901475651512

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.4625622833173, 196.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.0, 253.76446981786114

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.39925709611097, 254.0

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
229.94858517769745, 749.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 813.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
325.92622852317857, 1255.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
83.97359621189784, 1253.6494331756296

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.18385947015844, 913.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
140.0, 330.0

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
777.2541741611511, 728.675851669437

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
775.1936928691418, 258.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.9658558131846, 265.9414811306291

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 351.48546512989424

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.9024916687326, 659.2452411114366

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.0, 1260.9927387005469

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
900.0, 1186.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.7947438684029, 1045.4039387283462

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.73021524621873, 672.5825292862646

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.7246399763383, 1176.0

c246

c246

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
783.8020565500142, 723.8545540966187

c247

c247

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
535.8037095880737, 218.0

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.0, 280.23771926755694

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.9973027645896, 236.2077221497296

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.0, 274.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.0, 374.0

c251

c251

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
312.0, 1421.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.6610044770691, 1189.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.0, 1040.8240662449873

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 676.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
809.0, 1501.2399915200253

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 1441.3952501070144

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.0, 1232.9871708983303

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
934.0, 1137.0

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.7376077464221, 241.03209900411088

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.7524594051339, 1218.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
969.0, 788.0

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.0, 838.7067602675323

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 841.0

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
465.0032635011604, 907.0

c264

c264

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
772.9976215251444, 944.0

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 488.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.9987017202121, 944.1441207517155

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.9420849418726, 898.0

c268

c268

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
999.5378014698349, 972.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 246.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 824.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0588235294117, 1005.7647058823529

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.4, 820.0

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.7995172878431, 948.7797556227293

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.0, 488.0

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.994575417657, 984.2082480075555

c275

c275

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
707.0, 189.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.29760879953847, 290.0

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.0, 449.8474148597091

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.5952930207878, 442.0

c279

c279

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.8709592807993, 330.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
453.21843052680276, 386.0

c280

c280

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
398.0, 532.7618204050059

c281

c281

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 530.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.670591992256, 222.0

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.9957035442658, 412.26215421456607

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
774.9333765882019, 413.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 340.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0, 39.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.5500072830991, 344.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 404.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.8239426913944, 459.66910777416416

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.3564163240852, 465.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 583.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.0, 646.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.4512470998168, 723.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 979.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.0237707010416, 1071.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 1154.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.0, 32.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.3531602401445, 187.15135438863334

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 180.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.0, 245.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 227.47194186451253

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.9495670705456, 217.89687423360002

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.0, 225.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
52.0, 216.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
69.02787121906299, 247.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
62.0, 287.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
147.0, 311.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 51.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
240.96597336150688, 258.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
148.73897778704196, 343.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 372.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.60705256560414, 188.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.6921915811266, 403.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
147.0, 277.9088269514547

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
208.0, 189.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
143.44931222490783, 278.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
147.0, 497.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.49018805215496, 484.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
150.91164675130665, 42.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
149.5183473879075, 532.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
142.0, 557.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
249.22730431580263, 509.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.0, 579.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.0, 641.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
233.0, 688.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 616.3198934961206

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
373.0, 498.36465425500205

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.0, 415.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 466.5460518241941

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
923.0, 288.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.74672566954445, 481.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
398.0, 556.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 567.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0253358311251, 637.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
370.0, 683.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
321.88889554930375, 718.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.8760554854872, 643.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
416.0, 777.2896484304287

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.96750495905803, 783.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.0, 643.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
935.5964067667121, 292.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.3592553320611, 649.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 787.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0570138197744, 759.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 819.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 642.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
239.0, 849.4812755623188

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.0, 842.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.85709973013275, 753.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
365.9950799503341, 864.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
323.0, 796.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.0, 288.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.0, 878.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.21843052680276, 856.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
329.0, 796.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.5538553641523, 912.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 908.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.0, 794.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.8757304490793, 910.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
242.0, 473.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.6418321736994, 420.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 439.3343588757586

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back