1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17667936.csml convertedTime:2009.07.01.11:06

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins.
Authors Watters TM, Kenny EF, O'Neill LA.
Affiliation School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.wattert@tcd.ie
Abstract The Toll/IL-1 receptor (TIR) domain plays a central role in Toll-like receptor(TLR) signalling. All TLRs contain a cytoplasmic TIR domain, which, uponactivation, acts as a scaffold to recruit adaptor proteins. The adaptor proteinsMyD88, Mal, TRIF, TRAM and SARM are also characterized by the presence of a TIRdomain. MyD88, Mal, TRIF and TRAM associate with the TLRs via homophilic TIRdomain interactions whereas SARM utilizes its TIR domain to negatively regulateTRIF. It is well established that the differential recruitment of adaptors toTLRs provides a significant amount of specificity to the TLR-signallingpathways. Despite this, the TIR-TIR interface has not been well defined.However, structural studies have indicated the importance of TIR domain surfacesin mediating specific TIR-TIR interactions. Furthermore, recent findingsregarding the regulation of adaptors provide further insight into the crucialrole of the TIR domain in TLR signalling.
PMID 17667936
Model Abstract

Entity

MO000000212:TRAF6 MO000000248:IKK MO000019396:TLR1 MO000019397:TLR2 MO000022136:Ubc13 e1: e10: e100:Inflammatory cytokines e101:IRF1 e102:IRF1{active} e103:IRF1{active} e104:IFN-beta e105:Inos e106:IL-12p35 e107:Mal e108:TLR4{dimer}:MD-2:LPS:LBP:CD14:Mal e109:TLR4{dimer}:MD-2:LPS:LBP:CD14 e11:TLR2 e110:TRIF e111:dsRNA:TLR3:TRIF e112:TBK1:IKK-i e113:dsRNA:TLR3:TRIF:TBK1:IKK-i e114:dsRNA:TLR3:TRIF:TRAF6 e115:IRF-3 e116:IRF-3{active} e117:IRF-3{active} e118:dsRNA:TLR3:TRIF:TBK1{active}:IKK-i e119:TRAF3 e12:TLR2:TLR6 e120:NAP1 e121:RIP1 e122:dsRNA:TLR3:TRIF:RIP1 e123:TRAF6{active} e124:TRAM e125:TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM e126:TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM:TRIF e127:TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM:TRIF:RIP1 e128:TAB2:TAK1{active} e129:Mal{p} e13:TLR2:TLR6:Diacylated lipoproteins e130:TRAF1 e131:TRIF:TRAF1 e132:SARM e133:dsRNA:TLR3:TRIF:SARM e134:TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM:TRIF:SARM e135:TGF-Beta e136:MyD88{ub} e137:ST2 e138:IL-1:IL-1R e139:Mal:TRAF6 e14:triacylated lipoproteins e140:Btk e141:Mal{p} e142:SOCS1 e143:Mal{p}:SOCS1 e144:Mal{p}{ub}:SOCS1 e145:Caspase-1 e146:PKC-delta e147:Mal:PKC-delta e15:TLR2:TLR1:triacylated proteins e16:Lipoteichoic acid e17:TLR2:Lipoteichoic acid e18: e19: e2: e20: e21:TLR3 e22:dsRNA e23:dsRNA:TLR3 e24:TLR4 e25:LPS e26:TLR5 e27:Flagellin e28:TLR5:Flagellin e29:TLR7 e3: e30:ssRNA e31:TLR7:ssRNA e32:TLR8 e33:TLR8:ssRNA e34:TLR9 e35:CpG DNA e36:TLR9:CpG DNA e37:LBP e38:LPS:LBP e39:CD14 e4: e40:LPS:LBP:CD14 e41:MD-2 e42:TLR4:MD-2 e43:TLR4:MD-2:LPS:LBP:CD14 e44:CD36 e45:MyD88 e46:TLR4:MD-2:LPS:LBP:CD14:MyD88 e47:IRAK-4 e48:IRAK-1 e49:TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1 e5:diacylated lipoproteins e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR2:TLR1 e60: e61: e62: e63:TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p} e64:TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 e65:TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer e66:Uev1a e67:TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer{ub} e68:TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer{ub}:TAB2:TAK1 e69:TAB2:TAK1 e7: e70:TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer{ub}:TAB2:TAK1{active} e71:IKK{active} e72:NF-KappaB:IKappaB e73:NF-KappaB:IKappaB{p} e74:NF-KappaB:IKappaB{p}{ub} e75:Proteasome degradants e76:NF-KappaB{active} e77:NF-KappaB{active} e78:mRNA e79:MKK6 e8: e80:MKK6{active} e81:JNK e82:JNK{p} e83:p38{p} e84:p38 e85:AP-1 e86:AP-1{active} e87:MyD88:TRAF6:IRAK-4:IRAk-1 e88:MyD88:TRAF6:IRAK-4:IRAK-1:TLR7:ssRNA e89:IRF-7 e9: e90:MyD88:TRAF6{ub}:IRAK-4:IRAK-1{p}:TLR7:ssRNA:IRF-7 e91:MyD88:TRAF6{ub}:IRAK-4:IRAK-1{p}:TLR7:ssRNA:IRF-7{p} e92:IRF-7{p} e93:MyD88:TRAF6:IRAK-4:IRAK-1{p}:TLR7:ssRNA e94:MyD88:TRAF6{ub}:IRAK-4:IRAK-1{p}:TLR7:ssRNA e95:IFN-alpha e96:IFN inducible genes e97:IRF5 e98:IRF5{active} e99:IRF5{active}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p9
Model Detail
358.0, 546.0
20.0, 20.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p54 p61 p66 p69 p81

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
372.0, 1116.0
24.0, 24.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p65

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false

--

Go back
290.0, 242.0
20.0, 20.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false

--

Go back
241.0, 245.0
22.0, 22.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p5

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false

--

Go back
350.0, 882.0
20.0, 20.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
167.49331158085232, 220.8152178839352
1098.4902465751204, 1595.007838027074

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
196.0771886212408, 231.19417412862538
1064.7734357337793, 1497.836826216816

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
772.0, 1347.0
48.944636678200695, 26.103806228373703

Inflammatory cytokines

--

e100

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
373.0, 651.0
14.301216089803551, 33.00280636108512

IRF1

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
469.0, 723.0
14.301216089803551, 33.00280636108512

IRF1{active}

--

e102

cso30:c:Protein

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
769.0, 1127.0
14.301216089803551, 33.00280636108512

IRF1{active}

--

e103

cso30:c:Protein

cso30:i:CC_Cytosol

--

p46

p47 p48 p49

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
850.0, 1324.0
45.77854671280277, 24.41522491349481

IFN-beta

--

e104

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
933.0, 1200.0
45.46712802768166, 24.249134948096888

Inos

--

e105

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p48

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
710.0, 1416.0
39.55017301038062, 21.09342560553633

IL-12p35

--

e106

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p49

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
384.9935600724492, 302.5
30.778828738176696, 18.980277721875634

Mal

--

e107

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50 p70 p81 p82 p86 p87

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
507.0, 250.0
26.911764705882355, 44.852941176470594

TLR4{dimer}:MD-2:LPS:LBP:CD14:Mal

--

e108

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p15

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
551.0, 206.0
26.911764705882355, 44.852941176470594

TLR4{dimer}:MD-2:LPS:LBP:CD14

--

e109

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p50 p55

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
193.0, 285.0
22.0, 22.0

TLR2

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false

--

Go back
627.5, 298.0
16.96236667337493, 27.5065405514188

TRIF

--

e110

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52 p63 p71

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
828.5, 376.0
22.687649109928433, 31.6571848045513

dsRNA:TLR3:TRIF

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p53 p54 p60 p72 p73

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
604.5, 418.0
22.291284785869028, 27.29545075820697

TBK1:IKK-i

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
829.0, 414.0
21.529411764705884, 35.88235294117647

dsRNA:TLR3:TRIF:TBK1:IKK-i

--

e113

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p53

p59

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
537.0, 486.0
21.88235294117647, 36.47058823529412

dsRNA:TLR3:TRIF:TRAF6

--

e114

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
539.5, 638.0
16.776212517609178, 27.20466894747434

IRF-3

--

e115

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p56

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
559.5, 698.0
16.776212517609178, 27.20466894747434

IRF-3{active}

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
623.5, 1150.0
16.776212517609178, 27.20466894747434

IRF-3{active}

--

e117

cso30:c:Protein

cso30:i:CC_Cytosol

--

p57

p58

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
837.0, 654.0
21.529411764705884, 35.88235294117647

dsRNA:TLR3:TRIF:TBK1{active}:IKK-i

--

e118

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p59

p56

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
503.0, 556.5
25.93680821090763, 15.99436506339304

TRAF3

--

e119

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p59

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
196.5, 342.0
22.29128478586902, 27.295450758206965

TLR2:TLR6

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
422.0, 582.0
12.1244153414406, 27.979420018709074

NAP1

--

e120

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p59

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
483.0, 422.0
12.185219831618333, 28.119738072965383

RIP1

--

e121

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p60 p64

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
828.0, 504.0
23.91176470588236, 39.852941176470594

dsRNA:TLR3:TRIF:RIP1

--

e122

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p60

p61 p66

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
462.0, 626.0
20.0, 20.0

TRAF6{active}

--

e123

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61 p66 p69

p62 p67

true true true true

csml-variable:Double

m123

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
451.5, 298.0
16.8581203461461, 27.33749245320989

TRAM

--

e124

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p55

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
1201.0, 266.0
21.70588235294118, 36.176470588235304

TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM

--

e125

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p63

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
1213.0, 398.0
21.70588235294118, 36.176470588235304

TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM:TRIF

--

e126

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p64 p74 p75

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
1213.0, 462.0
21.70588235294118, 36.176470588235304

TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM:TRIF:RIP1

--

e127

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p69

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
496.5, 915.0
22.046325612397936, 26.99550074987502

TAB2:TAK1{active}

--

e128

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p65 p68

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
344.0, 434.0
24.8780487804878, 19.902439024390237

Mal{p}

--

e129

cso30:c:Protein

cso30:i:CC_Cytosol

--

p70

--

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
195.5, 415.0
24.621031381904935, 34.354927509634784

TLR2:TLR6:Diacylated lipoproteins

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
335.0, 360.5
25.76776011269873, 15.890118736164222

TRAF1

--

e130

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p71

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
414.5, 420.0
19.278286952174636, 23.606065655724045

TRIF:TRAF1

--

e131

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

--

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
1161.0, 887.0
14.386342376052381, 33.199251637043965

SARM

--

e132

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p72 p75

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
865.0, 882.0
21.97058823529412, 36.61764705882353

dsRNA:TLR3:TRIF:SARM

--

e133

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

p73

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
1213.0, 794.0
21.70588235294118, 36.176470588235304

TLR4{dimer}:MD-2:LPS:LBP:CD14:TRAM:TRIF:SARM

--

e134

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

p74

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
621.0, 800.5
21.279999999999998, 15.959999999999999

TGF-Beta

--

e135

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p76

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
297.0, 629.0
29.7480755773268, 22.806857942617214

MyD88{ub}

--

e136

cso30:c:Protein

cso30:i:CC_Cytosol

--

p76

p77

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
1205.0, 982.5
30.223384986918894, 18.637754075266653

ST2

--

e137

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p74 p78 p79 p80

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
1210.5, 1041.0
19.894102170576623, 38.504713878535405

IL-1:IL-1R

--

e138

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p78

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
383.5, 493.0
24.65922346275621, 30.194967505415768

Mal:TRAF6

--

e139

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
418.0, 144.0
43.952901597981494, 24.906644238856178

triacylated lipoproteins

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
557.0, 541.0
13.17025257249766, 30.392890551917677

Btk

--

e140

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p82

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
560.0, 603.0
32.195121951219505, 25.756097560975608

Mal{p}

--

e141

cso30:c:Protein

cso30:i:CC_Cytosol

--

p82

p83

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
1144.0, 1106.5
23.999999999999996, 17.999999999999996

SOCS1

--

e142

cso30:c:Protein

cso30:i:CC_Cytosol

--

p85

p83

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
1088.5, 1170.0
22.332111314780867, 27.345442426262295

Mal{p}:SOCS1

--

e143

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83

p84

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
1088.5, 1358.0
22.332111314780867, 27.345442426262295

Mal{p}{ub}:SOCS1

--

e144

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

p85

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
699.5, 846.0
16.85067417991548, 27.325417589052122

Caspase-1

--

e145

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p86

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
272.0, 375.5
23.04, 17.279999999999998

PKC-delta

--

e146

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p87

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
267.5, 501.0
24.389768371938008, 29.86502249625063

Mal:PKC-delta

--

e147

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

--

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
429.5, 220.0
29.048082216920537, 40.53220774454029

TLR2:TLR1:triacylated proteins

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p79

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
230.0, 127.0
44.457527333894035, 25.192598822539953

Lipoteichoic acid

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
201.5, 463.0
21.26024994518746, 41.14887086165316

TLR2:Lipoteichoic acid

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
822.0, 345.2657159653348
339.1551779720475, 566.2166954279099

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
822.0, 345.2657159653348
339.1551779720475, 566.2166954279099

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
167.49331158085232, 220.8152178839352
1098.4902465751204, 1595.007838027074

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
822.0, 345.2657159653348
339.1551779720475, 566.2166954279099

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
942.5, 335.0
26.95957820738137, 41.47627416520212

TLR3

--

e21

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p6

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
914.0, 187.5
27.265043268263224, 16.813443348762323

dsRNA

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
872.5, 329.0
23.67309800482351, 45.818899364174534

dsRNA:TLR3

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p52

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
618.5, 240.0
26.365553602811953, 40.562390158172235

TLR4

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
609.0, 134.5
29.836989333869994, 18.3994767558865

LPS

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11 p70

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
203.5, 541.0
24.423550087873462, 37.574692442882245

TLR5

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
121.0, 486.5
30.392433085127788, 18.742000402495474

Flagellin

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
197.5, 603.0
21.987502740627054, 42.556456917342686

TLR5:Flagellin

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1007.5, 353.0
24.195079086115992, 37.2231985940246

TLR7

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
189.46311651235484, 242.7850228154377
1054.5506367121159, 1551.06822816407

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1082.0, 168.5
44.661258495943876, 23.07498355623767

ssRNA

--

e30

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p8 p9

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1052.5, 375.0
22.001096250822187, 42.5827669370752

TLR7:ssRNA

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p34

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1087.5, 437.0
24.195079086115992, 37.2231985940246

TLR8

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1121.5, 483.0
21.341811006358252, 41.30673098004823

TLR8:ssRNA

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1131.5, 536.0
25.36028119507909, 39.015817223198596

TLR9

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1279.3242239320775, 498.0035818519501
57.67577606792253, 12.49641814804988

CpG DNA

--

e35

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1136.5, 599.0
22.001096250822187, 42.5827669370752

TLR9:CpG DNA

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p80

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
609.0, 68.5
30.24000000000001, 22.680000000000003

LBP

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
710.5, 147.0
27.900849858356942, 34.1643059490085

LPS:LBP

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
917.5, 239.0
21.184342926142087, 34.35298852887905

CD14

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
230.10725563563446, 281.2321814455664
973.2623584655579, 1474.1739109038115

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
845.5, 240.0
29.205909341163522, 40.752431638832824

LPS:LBP:CD14

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p14

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
541.0, 135.0
14.994387277829745, 34.602432179607106

MD-2

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
698.5, 228.0
26.161639726712213, 32.0346608898517

TLR4:MD-2

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
779.0, 214.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p51

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
186.5, 224.0
26.411247803163445, 40.632688927943754

CD36

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
250.0, 541.5
27.68, 20.759999999999998

MyD88

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p76

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
195.0, 666.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16 p45

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
268.0, 586.5
31.901791104850073, 19.67277118132421

IRAK-4

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
346.5, 700.0
19.672771181324215, 31.901791104850073

IRAK-1

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
195.0, 734.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
66.0, 336.0
43.952901597981494, 24.906644238856178

diacylated lipoproteins

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
541.0178829227252, 1068.654316454846
500.99038526511583, 454.34323579908994

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
595.1285763033145, 1079.4215906321122
292.9440986466414, 440.3490909592821

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
547.5484838479687, 1074.7184458854297
487.9291834146289, 442.2149769379231

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
548.4814268372894, 1075.65138887475
486.0632974359875, 440.3490909592821

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
541.0178829227252, 1068.654316454846
500.99038526511583, 454.34323579908994

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
541.0178829227252, 1068.654316454846
500.99038526511583, 454.34323579908994

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
548.4814268372894, 1075.65138887475
486.0632974359875, 440.3490909592821

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
906.7315347363659, 1255.242914318947
31.29912657765159, 28.33394616503202

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
824.6325516761608, 1385.85493282382
88.62958398544878, 80.23309708156415

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
541.0178829227252, 1068.654316454846
500.99038526511583, 454.34323579908994

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
367.5, 233.0
24.47958673554408, 29.975004165972333

TLR2:TLR1

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
659.0984978508432, 1270.560696174896
15.865629373300797, 7.639006735292995

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
658.5686995771102, 1247.7793704043827
54.30432305761851, 97.74778150371331

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
681.350025347623, 1311.3551632523274
8.476772379725814, 8.47677237972582

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
191.0, 810.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
195.0, 878.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
195.0, 942.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
385.0, 984.0
14.276894293732456, 32.94667913938259

Uev1a

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
195.0, 1022.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer{ub}

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21 p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
199.0, 1082.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer{ub}:TAB2:TAK1

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
372.5, 1051.0
22.046325612397936, 26.99550074987502

TAB2:TAK1

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p21 p67

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
181.92587118138238, 227.2336555146324
1077.2766987142131, 1526.473255742649

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
199.0, 1158.0
26.911764705882355, 44.852941176470594

TLR4:MD-2:LPS:LBP:CD14:MyD88:IRAK-4:IRAK-1{p}:TRAF6 oligomer{ub}:TAB2:TAK1{active}

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23 p29

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
388.0, 1192.0
24.0, 24.0

IKK{active}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23 p65

p24

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false

--

Go back
304.5, 1242.0
23.10781536410599, 28.295284119313454

NF-KappaB:IKappaB

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p24 p73 p74 p78 p79 p80

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
340.5, 1306.0
23.10781536410599, 28.295284119313454

NF-KappaB:IKappaB{p}

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
340.5, 1454.0
23.10781536410599, 28.295284119313454

NF-KappaB:IKappaB{p}{ub}

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
357.0, 1530.0
21.625502584721424, 20.904652498564047

Proteasome degradants

--

e75

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p26 p77 p85 p86

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
445.0, 1371.5
22.88, 17.16

NF-KappaB{active}

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26 p73 p74 p78 p79 p80

p27

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
609.0, 1299.5
22.88, 17.16

NF-KappaB{active}

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
646.0, 1290.0
51.95501730103806, 27.709342560553637

mRNA

--

e78

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
474.5, 996.0
19.82914067216744, 32.15536325216342

MKK6

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p29 p68

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
185.77455374152362, 254.1744334356218
1033.444373658312, 1500.5612305518707

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
474.5, 1092.0
19.82914067216744, 32.15536325216342

MKK6{active}

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29 p68

p30 p31

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
425.0, 954.5
30.40450794928557, 18.7494465687261

JNK

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
613.0, 853.0
37.3170731707317, 29.853658536585368

JNK{p}

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

p30

p32

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
584.0, 1083.0
32.3170731707317, 25.853658536585364

p38{p}

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31

p33

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
416.0, 1164.5
31.680000000000007, 23.76

p38

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
769.0, 891.0
14.301216089803555, 33.00280636108512

AP-1

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32 p33

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
733.0, 955.0
14.301216089803555, 33.00280636108512

AP-1{active}

--

e86

cso30:c:Protein

cso30:i:CC_Cytosol

--

p32 p33

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
825.0, 466.0
21.352941176470587, 35.588235294117645

MyD88:TRAF6:IRAK-4:IRAk-1

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
825.0, 546.0
21.352941176470587, 35.588235294117645

MyD88:TRAF6:IRAK-4:IRAK-1:TLR7:ssRNA

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34 p37

p38

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
635.5, 730.0
16.850674179915476, 27.325417589052126

IRF-7

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
198.03770723523405, 287.115211356611
1028.7261332127791, 1480.881746019806

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
837.0, 774.0
21.352941176470587, 35.588235294117645

MyD88:TRAF6{ub}:IRAK-4:IRAK-1{p}:TLR7:ssRNA:IRF-7

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p36

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
833.0, 826.0
21.352941176470587, 35.588235294117645

MyD88:TRAF6{ub}:IRAK-4:IRAK-1{p}:TLR7:ssRNA:IRF-7{p}

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
819.5, 1102.0
16.850674179915476, 27.325417589052126

IRF-7{p}

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37

p40 p41

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
837.0, 602.0
21.352941176470587, 35.588235294117645

MyD88:TRAF6:IRAK-4:IRAK-1{p}:TLR7:ssRNA

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
833.0, 718.0
21.352941176470587, 35.588235294117645

MyD88:TRAF6{ub}:IRAK-4:IRAK-1{p}:TLR7:ssRNA

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37 p39

p35

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
790.0, 1278.0
36.22837370242215, 19.32179930795848

IFN-alpha

--

e95

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
894.0, 1246.0
36.22837370242215, 19.32179930795848

IFN inducible genes

--

e96

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p41 p58

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
509.0, 779.5
22.880000000000003, 17.160000000000007

IRF5

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42 p62

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
545.0, 863.5
22.880000000000003, 17.160000000000007

IRF5{active}

--

e98

cso30:c:Protein

cso30:i:CC_Cytosol

--

p42 p62

p43

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
689.0, 1123.5
22.880000000000003, 17.160000000000007

IRF5{active}

--

e99

cso30:c:Protein

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
277.0, 325.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e11

e12 e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c15 : 1

m3964*m11*0.1

nodelay

--

true

0

false

PMID: 17667936,12763684 There are also a number of ligands such as lipoteichoic acid and mycobacterial lipoarabinomannan that appear to be recognized by TLR2 independent of TLR1 or TLR6

Go back
1208.0, 544.0
23.0, 23.0

p8

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m34*m35*0.1

nodelay

--

true

0

false

PMID: 17667936 Both TLR7 and TLR8 recognize the single-stranded RNA (ssRNA) from viruses, while TLR9 is responsible for detecting bacterial and viral CpG DNA motifs.

Go back
711.0, 67.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 e25

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m37*m25*0.1

nodelay

--

true

0

false

PMID: 17667936,15010525,15895089 It seems that an LPS response requires the sequential interaction and transfer of LPS to LPS-binding protein, the glycosylphosphatidylinositol-anchored protein CD14 and MD-2, and the simultaneous engagement of LPS and TLR4 by MD-2

Go back
807.0, 151.0
25.0, 25.0

p11

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 17667936,15010525,15895089 It seems that an LPS response requires the sequential interaction and transfer of LPS to LPS-binding protein, the glycosylphosphatidylinositol-anchored protein CD14 and MD-2, and the simultaneous engagement of LPS and TLR4 by MD-2

Go back
599.0, 167.0
25.0, 25.0

p11

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 e24

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m41*m24*0.1

nodelay

--

true

0

false

PMID: 17667936,15010525,15895089 It seems that an LPS response requires the sequential interaction and transfer of LPS to LPS-binding protein, the glycosylphosphatidylinositol-anchored protein CD14 and MD-2, and the simultaneous engagement of LPS and TLR4 by MD-2

Go back
711.0, 315.0
25.0, 25.0

p11

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m42*m40*0.1

nodelay

--

true

0

false

PMID: 17667936,15010525,15895089 It seems that an LPS response requires the sequential interaction and transfer of LPS to LPS-binding protein, the glycosylphosphatidylinositol-anchored protein CD14 and MD-2, and the simultaneous engagement of LPS and TLR4 by MD-2

Go back
316.0, 512.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 e108

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m45*m108*0.1

nodelay

--

true

0

false

PMID: 17667936 MyD88 is recruited to the cytoplasmic portion of the TLR and interacts with IRAK4 and IRAK1 via homophilic DD interactions. PMID: 17667936 Mal recruits MyD88, which binds IRAK4 and -1.

Go back
272.0, 676.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 e48 e46

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m47*m48*m46*0.1

nodelay

--

true

0

false

PMID: 17667936 MyD88 is recruited to the cytoplasmic portion of the TLR and interacts with IRAK4 and IRAK1 via homophilic DD interactions.

Go back
282.0, 746.0
19.0, 19.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17667936,11518704,9430229,12538665,12885415,11960013 17362201 Activated IRAK4 phosphorylates and activates IRAK1 which subsequently interacts with TNFR-associated factor-6 (TRAF6),causing the oligomerization and activation of TRAF6.

Go back
273.0, 821.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m183*m63*0.1

nodelay

--

true

0

false

PMID: 17667936,11518704,9430229,12538665,12885415,11960013 17362201 Activated IRAK4 phosphorylates and activates IRAK1 which subsequently interacts with TNFR-associated factor-6 (TRAF6),causing the oligomerization and activation of TRAF6.

Go back
282.0, 890.0
19.0, 19.0

p19

p19

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17667936,11518704,9430229,12538665,12885415,11960013 17362201 Activated IRAK4 phosphorylates and activates IRAK1 which subsequently interacts with TNFR-associated factor-6 (TRAF6),causing the oligomerization and activation of TRAF6.

Go back
325.0, 321.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000019396

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3964*m3963*0.1

nodelay

--

true

0

false

PMID: 17667936,11095740,15795223,16720699 TLR2 is known to form heterodimers with TLR1 or TLR6 while TLR4 homodimerizes in a similar fashion to dToll

Go back
277.0, 953.0
21.0, 21.0

p20

p20

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e65 MO000022136 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m65*m6443*m66*0.1

nodelay

--

true

0

false

PMID: 17667936,16056267,11057907 TRAF6 is a ubiquitin E3 ligase and functions with the ubiquitin-conjugating enzyme Ubc13 and the Ubc-like protein Uev1a to catalyze the synthesis of Lys63-linked polyubiquitin chains on target proteins including TRAF6 itself.

Go back
289.0, 1033.0
21.0, 21.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 e69

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m67*m69*0.1

nodelay

--

true

0

false

PMID: 17667936,16056267,11057907,10882101 Ubiquitinated TRAF6 then recruits TAB2 and activates the TAB2-associated TAK1 kinase

Go back
293.0, 1101.0
21.0, 21.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e68

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17667936,16056267,11057907,10882101 Ubiquitinated TRAF6 then recruits TAB2 and activates the TAB2-associated TAK1 kinase

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298.0, 1174.0
19.0, 19.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 MO000000248

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m70*m207*0.1

nodelay

--

true

0

false

PMID: 17667936 Activated TAK1 then activates the IKK complex which phosphorylates IkappaB resulting in its ubiquitination and subsequent proteosome-mediated degradation.

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429.0, 1269.0
21.0, 21.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e71 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m71*m72*0.1

nodelay

--

true

0

false

Go back
341.0, 1381.0
21.0, 21.0

p25

p25

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m73*0.1

nodelay

--

true

0

false

Go back
428.0, 1456.0
23.0, 23.0

p26

p26

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e74

e75 e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17667936 Activated TAK1 then activates the IKK complex which phosphorylates IkappaB resulting in its ubiquitination and subsequent proteosome-mediated degradation. PMID: 17667936,15371334,11460167 This leaves NF-kappaB free to translocate to the nucleus and initiate gene transcription

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476.0, 1296.0
23.0, 23.0

p27

p27

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 17667936,15371334,11460167 This leaves NF-kappaB free to translocate to the nucleus and initiate gene transcription

Go back
612.0, 1220.0
23.0, 23.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17667936,15371334,11460167 This leaves NF-kappaB free to translocate to the nucleus and initiate gene transcription

Go back
431.0, 1047.0
25.0, 25.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m70*m79*0.1

nodelay

--

true

0

false

PMID: : 17667936,11460167 TAK1 is also responsible for the activation of MKK6 which phosphorylates and activates the kinases JNK and P38 and thereby mediates AP-1 activation

Go back
97.0, 385.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e12 e44

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c43 : 1
stoichiometry:c9 : 1

m5*m12*m44*0.1

nodelay

--

true

0

false

PMID: 17667936,12077222 While the TLR2/TLR6 heterodimer detects diacylated lipoproteins from bacteria, the TLR2/TLR1 heterodimer senses triacylated lipoproteins. PMID: 17667936,15690042 CD14 has also been shown to be required for signalling induced by TLR2 ligands,and it has been found recently that the scavenger receptor CD36 is involved in recognition of diacylated lipopeptides by TLR2/6 heterodimers.

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505.0, 973.0
21.0, 21.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e80 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m80*m81*0.1

nodelay

--

true

0

false

PMID: : 17667936,11460167 TAK1 is also responsible for the activation of MKK6 which phosphorylates and activates the kinases JNK and P38 and thereby mediates AP-1 activation

Go back
505.0, 1165.0
21.0, 21.0

p30

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e80 e84

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m80*m84*0.1

nodelay

--

true

0

false

PMID: : 17667936,11460167 TAK1 is also responsible for the activation of MKK6 which phosphorylates and activates the kinases JNK and P38 and thereby mediates AP-1 activation

Go back
680.0, 896.0
23.0, 23.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m82*m85*0.1

nodelay

--

true

0

false

PMID: : 17667936,11460167 TAK1 is also responsible for the activation of MKK6 which phosphorylates and activates the kinases JNK and P38 and thereby mediates AP-1 activation

Go back
564.0, 960.0
23.0, 23.0

p32

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e83 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m83*m85*0.1

nodelay

--

true

0

false

PMID: : 17667936,11460167 TAK1 is also responsible for the activation of MKK6 which phosphorylates and activates the kinases JNK and P38 and thereby mediates AP-1 activation

Go back
933.0, 413.0
21.0, 21.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e87 e31

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m87*m31*0.1

nodelay

--

true

0

false

PMID: 17667936,15361868,15492225,15767370 Upon ligand binding to TLR 7, 8 or 9, IRF7 is recruited to a complex containing MyD88, TRAF6, IRAK4 and IRAK1.

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693.0, 685.0
21.0, 21.0

p34

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e94 e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m94*m89*0.1

nodelay

--

true

0

false

PMID: 17667936,15361868,15492225,15767370 Upon ligand binding to TLR 7, 8 or 9, IRF7 is recruited to a complex containing MyD88, TRAF6, IRAK4 and IRAK1.

Go back
693.0, 753.0
21.0, 21.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17667936 Phosphorylation of IRF7 by IRAK1 in this complex was found to be essential for its transcriptional activation.

Go back
762.0, 1022.0
19.0, 19.0

p37

p37

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e91

e88 e92 e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c112 : 1

m91*0.1

nodelay

--

true

0

false

PMID: 17667936 This results in the activation of IRF7 which translocates to the nucleus to produce IFN-alpha and IFN-inducible genes.

Go back
721.0, 553.0
21.0, 21.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e88

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
693.0, 569.0
21.0, 21.0

p39

p39

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
509.0, 145.0
21.0, 21.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e6

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m6*0.1

nodelay

--

true

0

false

PMID: 17667936,12077222 While the TLR2/TLR6 heterodimer detects diacylated lipoproteins from bacteria, the TLR2/TLR1 heterodimer senses triacylated lipoproteins.

Go back
798.0, 1206.0
19.0, 19.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e92

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 17667936 This results in the activation of IRF7 which translocates to the nucleus to produce IFN-alpha and IFN-inducible genes.

Go back
838.0, 1190.0
19.0, 19.0

p40

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e92

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 17667936 This results in the activation of IRF7 which translocates to the nucleus to produce IFN-alpha and IFN-inducible genes.

Go back
465.0, 873.0
21.0, 21.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e67 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m67*m97*0.1

nodelay

--

true

0

false

PMID: 17667936 TRAF6 can also activate IRF5.

Go back
662.0, 1042.0
19.0, 19.0

p43

p43

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m98*0.1

nodelay

--

true

0

false

PMID: 17667936,15665823 It was shown that IRF5 interacts with, and is activated by MyD88 and TRAF6 causing the nuclear translocation of IRF5 and the expression of inflammatory cytokines.

Go back
690.0, 1210.0
19.0, 19.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m99*0.1

nodelay

--

true

0

false

Go back
368.0, 748.0
24.0, 24.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e46 e101

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m46*m101*0.1

nodelay

--

true

0

false

PMID: 17667936,17018642 Upon TLR activation, IRF1 is activated by MyD88, causing it to translocate to the nucleus where it induces a specific gene subset including IFN-beta, inducible NO synthase and IL-12p35

Go back
701.0, 1017.0
23.0, 23.0

p46

p46

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m102*0.1

nodelay

--

true

0

false

Go back
749.0, 1225.0
21.0, 21.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 17667936,17018642 Upon TLR activation, IRF1 is activated by MyD88, causing it to translocate to the nucleus where it induces a specific gene subset including IFN-beta, inducible NO synthase and IL-12p35

Go back
877.0, 1133.0
21.0, 21.0

p47

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e103

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 17667936,17018642 Upon TLR activation, IRF1 is activated by MyD88, causing it to translocate to the nucleus where it induces a specific gene subset including IFN-beta, inducible NO synthase and IL-12p35

Go back
709.0, 1261.0
21.0, 21.0

p47

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e103

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 17667936,17018642 Upon TLR activation, IRF1 is activated by MyD88, causing it to translocate to the nucleus where it induces a specific gene subset including IFN-beta, inducible NO synthase and IL-12p35

Go back
245.0, 185.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m3964*m16*0.1

nodelay

--

true

0

false

Go back
518.0, 374.0
19.0, 19.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e107 e109

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m107*m109*0.1

nodelay

--

true

0

false

PMID: 17667936 It is initiated in the case of TLR4 by the TIR domain of Mal binding the TIR domain of TLR4, which has dimerized after ligand binding.

Go back
561.0, 321.0
21.0, 21.0

p51

p51

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e43

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c169 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17667936 It is initiated in the case of TLR4 by the TIR domain of Mal binding the TIR domain of TLR4, which has dimerized after ligand binding.

Go back
701.0, 381.0
21.0, 21.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 e110

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m23*m110*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1 PMID: 17667936,14679297,14530355 TRIF mediates IRF3 activation via TRAF family member-associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1), which associates with the N terminus of TRIF

Go back
729.0, 433.0
21.0, 21.0

p52

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e111 e112

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m111*m112*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1 PMID: 17667936,14679297,14530355 TRIF mediates IRF3 activation via TRAF family member-associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1), which associates with the N terminus of TRIF

Go back
653.0, 513.0
22.0, 22.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e111 MO000000212

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m111*m183*0.1

nodelay

--

true

0

false

Go back
622.0, 362.0
19.0, 19.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e109 e124

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m109*m124*0.1

nodelay

--

true

0

false

PMID: 17667936,14517278 It functions as a bridging adaptor for the MyD88-independent signalling pathway, serving to recruit TRIF to TLR4

Go back
609.0, 633.0
21.0, 21.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e115 e118

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c156 : 1
stoichiometry:c150 : 1

m115*m118*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
621.0, 1049.0
19.0, 19.0

p57

p57

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e116

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m116*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
662.0, 1246.0
19.0, 19.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e117

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
630.0, 570.0
19.0, 19.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e113 e119 e120

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c155 : 1

m113*m119*m120*0.1

nodelay

--

true

0

false

PMID: 17667936,16306937,16306936,15611223 Recently, both TRAF3 and NAK-associated protein 1 (NAP1) have been implicated in mediating the activation of TBK1 by TRIF by acting as a bridge between the two proteins

Go back
1016.0, 184.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 e21

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m22*m21*0.1

nodelay

--

true

0

false

PMID: 17667936 TLR3 detects the double-stranded RNA (dsRNA) from viruses.

Go back
562.0, 454.0
19.0, 19.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e121 e111

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m121*m111*0.1

nodelay

--

true

0

false

PMID: 17667936,15064760 TRIF also associates with receptor-interacting protein 1 (RIP1) via its C-terminal RIP homotypic interaction motif (RHIM), and in the absence of RIP1, TLR3-mediated NF-kappaB activation was abolished, suggesting that RIP1 mediates the TRIF-induced NF-kappaB activation

Go back
461.0, 501.0
21.0, 21.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e122 MO000000212

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m122*m183*0.1

nodelay

--

true

0

false

PMID: 17667936 Alternatively RIP1 is activated by TRIF and this feeds into the MyD88 pathway by activating TRAF6.

Go back
389.0, 809.0
21.0, 21.0

p61

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e123 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m123*m97*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
953.0, 469.0
22.0, 22.0

p55

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e110 e125

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m110*m125*0.1

nodelay

--

true

0

false

PMID: 17667936,14517278 It functions as a bridging adaptor for the MyD88-independent signalling pathway, serving to recruit TRIF to TLR4

Go back
969.0, 501.0
21.0, 21.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e126 e121

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m126*m121*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
413.0, 1013.0
21.0, 21.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_EndosomeLumen

--

e128 MO000000248

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m128*m207*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
329.0, 789.0
21.0, 21.0

p61

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e122 MO000000212

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m122*m183*0.1

nodelay

--

true

0

false

PMID: 17667936 Alternatively RIP1 is activated by TRIF and this feeds into the MyD88 pathway by activating TRAF6.

Go back
325.0, 845.0
21.0, 21.0

p61

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e123 e69

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m123*m69*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
553.0, 1001.0
21.0, 21.0

p65

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_EndosomeLumen

--

e128 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m128*m79*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
369.0, 377.0
21.0, 21.0

p65

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_EndosomeLumen

--

e127 MO000000212

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m127*m183*0.1

nodelay

--

true

0

false

PMID: 17667936 Figure 1

Go back
125.0, 549.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m27*m26*0.1

nodelay

--

true

0

false

PMID: 17667936 TLR5 senses flagellin, a highly conserved component of bacterial flagella.

Go back
387.0, 355.0
17.0, 17.0

p70

p70

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e107 e25

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c195 : 1
stoichiometry:c194 : 1

m107*m25*0.1

nodelay

--

true

0

false

PMID: 17667936 It was found that TRAM was phosphorylated on serine-16 by PKCalt epsilon upon LPS stimulation PMID: 17667936 Figure 2

Go back
557.0, 373.0
21.0, 21.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e130 e110

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m130*m110*0.1

nodelay

--

true

0

false

PMID: 17667936 The TIR domain of TRIF was involved in the interaction with the TRAF-C domain of TRAF1, and inhibition most likely occurs through sequestration of the TIR domain.

Go back
1053.5, 918.0
23.5, 23.5

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e111 e132

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m111*m132*0.1

nodelay

--

true

0

false

PMID: 17667936 SARM associates with TRIF and blocks TRIF-induced NF-kappaB activation.

Go back
929.0, 973.0
22.0, 22.0

p73

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e111 e72 e133

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c205 : 1
stoichiometry:c204 : 1

m111*m72*0.1

nodelay

--

true

0

false

PMID: 17667936 SARM associates with TRIF and blocks TRIF-induced NF-kappaB activation.

Go back
1009.0, 985.0
22.0, 22.0

p73

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e126 e72 e134 e137

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c212 : 1
stoichiometry:c226 : 1
stoichiometry:c208 : 1

m126*m72*0.1

nodelay

--

true

0

false

PMID: 17667936 SARM associates with TRIF and blocks TRIF-induced NF-kappaB activation. PMID: 17667936 It was found that the membrane bound form of ST2, which contains a TIR domain, specifically inhibited NF-kappaB activation downstream of IL-1R, TLR2, TLR4 and TLR9 but not TLR3.

Go back
1112.5, 820.0
23.5, 23.5

p72

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e126 e132

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1
stoichiometry:c211 : 1

m126*m132*0.1

nodelay

--

true

0

false

PMID: 17667936 SARM associates with TRIF and blocks TRIF-induced NF-kappaB activation.

Go back
329.0, 581.0
19.0, 19.0

p76

p76

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e135 e45

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m135*m45*0.1

nodelay

--

true

0

false

PMID: 17667936 Transforming growth factor-beta (TGF-beta) partly exerts its anti-inflammatory effects by causing direct ubiquitination of MyD88, thereby augmenting its degradation by the proteasome.

Go back
373.0, 837.0
19.0, 19.0

p77

p77

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e136

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m136*0.1

nodelay

--

true

0

false

PMID: 17667936 Transforming growth factor-beta (TGF-beta) partly exerts its anti-inflammatory effects by causing direct ubiquitination of MyD88, thereby augmenting its degradation by the proteasome.

Go back
1025.0, 1049.0
21.0, 21.0

p78

p78

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e138 e72 e137

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c221 : 1
stoichiometry:c220 : 1

m138*m72*0.1

nodelay

--

true

0

false

PMID: 17667936 It was found that the membrane bound form of ST2, which contains a TIR domain, specifically inhibited NF-kappaB activation downstream of IL-1R, TLR2, TLR4 and TLR9 but not TLR3.

Go back
821.0, 953.0
21.0, 21.0

p78

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e15 e72 e137

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c225 : 1
stoichiometry:c224 : 1

m15*m72*0.1

nodelay

--

true

0

false

PMID: 17667936 It was found that the membrane bound form of ST2, which contains a TIR domain, specifically inhibited NF-kappaB activation downstream of IL-1R, TLR2, TLR4 and TLR9 but not TLR3.

Go back
1060.0, 248.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m30*m29*0.1

nodelay

--

true

0

false

PMID: 17667936 Both TLR7 and TLR8 recognize the single-stranded RNA (ssRNA) from viruses, while TLR9 is responsible for detecting bacterial and viral CpG DNA motifs.

Go back
885.0, 945.0
21.0, 21.0

p78

p80

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e72 e137

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c228 : 1
stoichiometry:c230 : 1
stoichiometry:c229 : 1

m36*m72*0.1

nodelay

--

true

0

false

PMID: 17667936 It was found that the membrane bound form of ST2, which contains a TIR domain, specifically inhibited NF-kappaB activation downstream of IL-1R, TLR2, TLR4 and TLR9 but not TLR3.

Go back
313.0, 429.0
21.0, 21.0

p81

p81

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e107 MO000000212

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m107*m183*0.1

nodelay

--

true

0

false

PMID: 17667936 Indeed, Mal could associate with TRAF6 in a co-immunoprecipitation assay.

Go back
450.0, 450.0
19.0, 19.0

p82

p82

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e140 e107

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c236 : 1

m140*m107*0.1

nodelay

--

true

0

false

PMID: 17667936 It was also shown that Mal is phosphorylated by Bruton's tyrosine kinase (Btk) on tyrosine residues at positions 86 and 187, and this event is necessary for efficient TLR4 signalling.

Go back
1006.0, 1106.0
19.0, 19.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e141 e142

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c238 : 1
stoichiometry:c239 : 1

m141*m142*0.1

nodelay

--

true

0

false

PMID: 17667936 A prerequisite for Mal degradation is tyrosine phosphorylation of Mal by Btk as this may allow SOCS1 to associate with Mal through its SH2 domain.

Go back
1090.0, 1262.0
19.0, 19.0

p84

p84

cso30:i:ME_Ubiquitination

cso30:i:CC_Extracellular

--

e143

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1

m143*0.1

nodelay

--

true

0

false

PMID: 17667936 Here it was shown that SOCS1 mediates polyubiquitination of Mal on two N-terminal lysine residues, thereby mediating Mal degradation via the 26S proteasome.

Go back
1091.0, 1447.0
17.0, 17.0

p85

p85

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e144

e75 e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c243 : 1
stoichiometry:c244 : 1

m144*0.1

nodelay

--

true

0

false

PMID: 17667936 Here it was shown that SOCS1 mediates polyubiquitination of Mal on two N-terminal lysine residues, thereby mediating Mal degradation via the 26S proteasome.

Go back
489.0, 653.0
21.0, 21.0

p86

p86

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e145 e107

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c247 : 1

m145*m107*0.1

nodelay

--

true

0

false

PMID: 17667936 It was also recently found that Mal is cleaved by caspase-1.

Go back
265.0, 437.0
21.0, 21.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e146 e107

e147

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m146*m107*0.1

nodelay

--

true

0

false

PMID: 17667936,17161867 In addition, Mal was shown to interact via its TIR domain with protein kinase C-delta (PKCdelta)

Go back
1132.0, 340.0
23.0, 23.0

p8

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m30*m32*0.1

nodelay

--

true

0

false

PMID: 17667936 Both TLR7 and TLR8 recognize the single-stranded RNA (ssRNA) from viruses, while TLR9 is responsible for detecting bacterial and viral CpG DNA motifs.

Go back
263.0, 266.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.0, 156.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 564.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.0, 569.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.7108315731365, 585.1314493779402

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.0, 590.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.6921915811266, 701.197769023179

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.8499053264452, 862.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.0, 589.924210607928

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.0, 1041.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 709.9221668432239

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 703.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 167.39798098238026

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.8519247362055, 767.5320828753572

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 770.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
774.0, 761.7679119982664

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.5296867331132, 1129.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
808.0, 1225.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.0, 1129.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
857.0, 1208.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 895.0993238318426

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.34640108602343, 797.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 875.2063839173712

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.3403601260162, 166.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 881.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.0, 1061.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 1141.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 1229.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 694.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
380.0, 684.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 743.6275716545526

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.0, 749.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 1040.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.3348664295432, 1160.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
253.0, 213.9895013078127

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 1245.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 1144.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
898.0, 1154.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.1951186300456, 1160.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
721.0, 1282.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.3318188452298, 242.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 321.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.5053180319735, 302.98402490518174

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.8358429531904, 251.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.7933861955235, 355.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.0, 152.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 321.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.0, 392.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.100675391283, 398.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0, 433.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 434.0046414913291

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.4099757125853, 401.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.0, 525.8675800814034

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.886569358273, 507.3423947843869

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.4341519259657, 440.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 645.8999121222475

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.6505331807702, 346.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.8646150223079, 654.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 725.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 1068.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.0, 1177.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 1256.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.0, 584.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.9376316715822, 645.996997214788

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.0, 566.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 581.610459796394

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.0, 438.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 196.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.7231190962884, 395.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 466.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.99519294922544, 512.2772899288749

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.0, 520.1084259767994

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.0, 522.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.92380548480276, 646.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
417.7376077464221, 791.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.0, 823.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 251.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.5699763999032, 258.9796695986459

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.0, 214.2868259682744

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 315.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 287.2005349595908

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 316.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.2847525831504, 293.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.0, 420.8941457955749

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
997.4415416432639, 420.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.0, 437.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.0, 482.066624529246

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.00910799488605, 531.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
341.926459684428, 566.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.4299368721978, 207.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.0, 652.2341704273325

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
347.20612692933304, 646.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
339.81117865827, 873.7922802739523

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 860.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.2680368629481, 941.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
389.0, 1041.483106108641

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
403.05402201541267, 1034.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 942.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
494.0, 1012.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.1377589008833, 1022.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
136.0, 505.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.9525898512113, 389.8696635317242

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.0, 405.98180078629116

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 398.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.46977617561174, 321.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.5777087639997, 372.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.7650891886901, 153.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
361.0, 369.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.4897634151657, 321.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.5894663844041, 388.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.0, 408.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.0, 262.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 560.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.7611400011626, 906.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.9047719270909, 903.2306830545172

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 408.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 992.1969462799115

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.1904668060749, 993.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.0, 914.0

c205

c205

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1026.6568293442629, 434.0

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 1002.7763617719803

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.6090432771051, 1003.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1128.873841422636, 434.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.0, 569.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.1772308771083, 850.8228104326101

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.0, 815.6275716545526

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.9715523371187, 822.0

c212

c212

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
354.42804193313344, 602.762381432212

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
278.0, 559.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
321.8646187432907, 600.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 652.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.1779974679793, 856.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.0, 1060.0

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 1065.1040022257848

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.925218979384, 192.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0062719872055, 1066.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1049.757791695803, 998.0

c221

c221

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
455.0, 261.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 973.9401803302952

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.3583115358221, 974.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.9897789303444, 965.2857692897767

c225

c225

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1034.9989434759457, 992.0

c226

c226

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
908.8065987840068, 635.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 965.6743420756

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.7585102661732, 966.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1029.0, 278.25848485227027

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.9758581887227, 957.438807091063

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
334.07841912241383, 321.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.80898753270714, 457.49063342055234

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 449.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.85286368119625, 473.453804793842

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.0, 321.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.0, 469.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.0, 629.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 1116.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 1123.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1065.4607722807734, 271.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 1197.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 1281.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 1385.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.9474668479874, 1457.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1101.0, 1132.8898229267922

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.8229000641898, 678.4857847973157

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
403.0, 321.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.1831076448379, 674.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.0809056378665, 393.0

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.36864526934903, 321.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.0, 192.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 458.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.0, 370.3787016788269

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.598319585933, 363.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1157.0, 556.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1237.8874122257146, 511.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.0, 270.1057411452476

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.952389692232, 567.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 80.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
639.0, 92.3729800074793

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 92.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 164.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0990127707684, 179.17706897983828

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 176.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 155.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.9402850002907, 199.76114000116266

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 188.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.0, 267.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 260.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.1554175279994, 267.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.0, 260.43779304227263

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
119.15776855821106, 265.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
278.0, 532.266928480466

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
341.8500647005202, 289.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.72254881859115, 535.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.0, 606.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.4667648496245, 694.8718326344709

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 688.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.0, 301.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.94635316997733, 699.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 756.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.06735586479, 765.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
289.3400347351484, 566.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 832.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.9405577885492, 842.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 900.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.4, 908.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 964.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.65685424949237, 902.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
226.7766576685863, 339.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.56298385301017, 970.6079254665552

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
227.65685424949237, 974.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 1044.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.78244971748296, 1047.8529642184483

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.60759898801274, 1051.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 1105.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.41146490620713, 1120.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 1181.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
323.46988867442553, 1137.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.0, 1186.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
94.0, 361.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 1216.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
328.0, 1258.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.2636750760036, 1285.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 1334.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.0, 1402.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.0, 1468.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.65685424949237, 1479.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.0, 1396.8746931459784

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 1326.3387600887686

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 1308.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
125.44715717293148, 361.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.0, 1250.9889426346601

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.0, 1243.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 1070.6744402872914

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.1214751973158, 1023.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.0, 1072.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 1001.75174492102

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.0, 968.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.0, 888.6568542494924

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 1124.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.0, 1176.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
118.0, 400.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 1114.5099956953175

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
650.0, 880.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.0, 908.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.0, 919.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.4932851665861, 990.8593956136114

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
594.6223053976245, 910.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.0, 972.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
846.0, 433.8646187432907

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.7924678801467, 399.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.8776860867976, 434.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back