_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e3
_enti_e2
_enti_e55
_enti_e59
_enti_e53
_enti_e56
_enti_e52
_enti_e54
_enti_e50
_enti_e51
_enti_e58
_enti_e61
_enti_e57
_enti_e62
_enti_e60
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6
c5 cso30:c:InputAssociation connector
c1 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17669557
Bradykinin binds to receptor BDKRB1.
c2 cso30:c:InputProcess connector
c3 cso30:c:InputProcess connector
c4 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6
c7 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6
c9 cso30:c:InputAssociation connector
c8 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6.
c10 cso30:c:InputAssociation connector
c11 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6.
c12 cso30:c:InputAssociation connector
c14 cso30:c:InputAssociation connector
c13 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 17669557
LPS binds TLR4.
c15 cso30:c:InputProcess connector
c16 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-α and IL-1β.
c19 cso30:c:InputAssociation connector
c23 cso30:c:InputInhibitor connector
c18 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-α and IL-1β.
PMID: 17669557
BK-induced attenuation of LPS-induced TNF-α formation was suppressed by 10 μM NS398, a cyclooxygenase-2 (COX-2) inhibitor, and 50 μM RpcAMP, a membrane-permeable cAMP inhibitor.
c20 cso30:c:InputAssociation connector
c22 cso30:c:InputAssociation connector
c24 cso30:c:InputInhibitor connector
c50 cso30:c:InputInhibitor connector
c51 cso30:c:InputInhibitor connector
c21 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-α and IL-1β.
c26 cso30:c:InputAssociation connector
c31 cso30:c:InputInhibitor connector
c25 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-α and IL-1β.
c28 cso30:c:InputAssociation connector
c29 cso30:c:InputAssociation connector
c30 cso30:c:InputInhibitor connector
c27 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 17669557
BK-induced Ca2+ rises in primary cultured microglia were observed.
c33 cso30:c:InputAssociation connector
c32 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17669557
ATP binds to receptor P2X and P2Y.
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17669557
ATP evoked an increase of [Ca2+] even in cells which did not respond to BK, suggesting that the majority of cultured microglial cells possess ATP receptors while only a minority have functional BK receptors.
c38 cso30:c:InputAssociation connector
c37 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17669557
ATP evoked an increase of [Ca2+] even in cells which did not respond to BK, suggesting that the majority of cultured microglial cells possess ATP receptors while only a minority have functional BK receptors.
c43 cso30:c:InputAssociation connector
c39 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17669557
ATP binds to receptor P2X and P2Y.
c40 cso30:c:InputProcess connector
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17669557
The immunocytochemical analysis using a specific antibody against iNOS showed stronger expression of iNOS in BK-treated microglia identified by isolectin B4-labeling.
c45 cso30:c:InputAssociation connector
c44 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17669557
The immunocytochemical analysis using a specific antibody against iNOS showed stronger expression of iNOS in BK-treated microglia identified by isolectin B4-labeling.
PMID: 17669557
This increase was prevented by the treatment of the cells with 10 μM BAPTA-AM, a membrane-permeable Ca2+ chelator, hinting to a link between BK induced Ca2+ signaling and iNOS expression.
c46 cso30:c:InputAssociation connector
c48 cso30:c:InputAssociation connector
c49 cso30:c:InputInhibitor connector
c47 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17669557, 12551746, 15145558
In microglia, the inducible expression of B1 was shown by application of LPS and BK.
c53 cso30:c:InputAssociation connector
c52 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17669557, 12551746, 15145558
In microglia, the inducible expression of B1 was shown by application of LPS and BK.
c55 cso30:c:InputAssociation connector
c54 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 17669557
PGE2 release was also increased in astrocytes after application of LPS or BK.
c57 cso30:c:InputAssociation connector
c56 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17669557
PGE2 release was also increased in astrocytes after application of LPS or BK.
c59 cso30:c:InputAssociation connector
c58 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17669557
BK also up-regulated mRNA for neurotrophic factors such as nerve growth factor (NGF).
c61 cso30:c:InputAssociation connector
c60 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 17669557
BK and ET, but not substance P (SubP) at concentration of 100 nM increased the mRNA level for NGF.
c66 cso30:c:InputAssociation connector
c62 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 17669557
Endothelin-1 binds to its receptor.
c63 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17669557
We also observed up-regulation of brain-derived neurotrophic factor (BDNF) mRNA level.
c68 cso30:c:InputAssociation connector
c67 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 17669557
The amount of NGF was significantly increased by 100 nM BK after 6 h, but not after 3 h of incubation in accordance with the time course of up-regulation of NGF mRNA level.
c69 cso30:c:InputAssociation connector
c71 cso30:c:InputAssociation connector
c70 cso30:c:OutputProcess connector
p28_propro_p28
c73 cso30:c:InputAssociation connector
p29_propro_p29
c72 cso30:c:InputAssociation connector
p30_propro_p30
c74 cso30:c:InputAssociation connector
c75 cso30:c:OutputProcess connector
Bradykinin_enti_e5
Bradykinin
MMP-9_enti_G010279
MMP-9
Bradykinin receptor_enti_e6
Bradykinin receptor
Bradykinin:Bradykinin receptor_enti_e11
Bradykinin:Bradykinin receptor
PLA2_enti_e12
PLA2
COX2_enti_G029941
COX2
IL-6_enti_G010262
IL-6
IL-6_enti_MO000007384
IL-6
LPS_enti_MO000016882
LPS
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e13
LPS:TLR4
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
IL-1beta_enti_G010389
IL-1beta
IL-1beta_enti_MO000016597
IL-1beta
calcium_enti_e14
calcium
ATP_enti_e15
ATP
P2Y_enti_e16
P2Y
ATP:P2Y_enti_e17
ATP:P2Y
P2X_enti_e18
P2X
ATP:P2X_enti_e19
ATP:P2X
iNOS_enti_G010514
iNOS
iNOS_enti_MO000021201
iNOS
BAPTA-AM_enti_e20
BAPTA-AM
NS398_enti_e21
NS398
RpcAMP_enti_e22
RpcAMP
BDKRB1_enti_G011021
BDKRB1
PGE2_enti_MO000021939
PGE2
NGF_enti_e23
NGF
endotheline-1_enti_e24
endotheline-1
ETR_enti_e25
ETR
ET:ETR_enti_e26
ET:ETR
BDNF_enti_G012199
BDNF
NGF_enti_MO000009818
NGF